US3720760B1 - - Google Patents

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Publication number
US3720760B1
US3720760B1 US75813168A US3720760B1 US 3720760 B1 US3720760 B1 US 3720760B1 US 75813168 A US75813168 A US 75813168A US 3720760 B1 US3720760 B1 US 3720760B1
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US
United States
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Pfizer Health AB
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Pharmacia AB
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Application filed by Pharmacia AB filed Critical Pharmacia AB
Priority to US00758131A priority Critical patent/US3720760A/en
Publication of US3720760A publication Critical patent/US3720760A/en
Assigned to PHARMACIA, INC., A CORP. OF N.J. reassignment PHARMACIA, INC., A CORP. OF N.J. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: PHARMACIA AB, A CORP. OF SWEDEN
Assigned to PHARMACIA AB. reassignment PHARMACIA AB. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: PHARMACIA, INC.
Application granted granted Critical
Publication of US3720760B1 publication Critical patent/US3720760B1/en
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Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/804Radioisotope, e.g. radioimmunoassay
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
US00758131A 1968-09-06 1968-09-06 Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples Expired - Lifetime US3720760A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US00758131A US3720760A (en) 1968-09-06 1968-09-06 Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00758131A US3720760A (en) 1968-09-06 1968-09-06 Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples

Publications (2)

Publication Number Publication Date
US3720760A US3720760A (en) 1973-03-13
US3720760B1 true US3720760B1 (pt) 1984-02-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
US00758131A Expired - Lifetime US3720760A (en) 1968-09-06 1968-09-06 Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples

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US (1) US3720760A (pt)

Cited By (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852415A (en) * 1972-10-13 1974-12-03 Hoffmann La Roche Compositions for use in radioimmunoassay as a substitute for blood plasma extract in determination of carcinoembryonic antigen
US3857931A (en) * 1971-02-01 1974-12-31 Hoffmann La Roche Latex polymer reagents for diagnostic tests
US3896217A (en) * 1973-03-19 1975-07-22 Summa Corp Method and apparatus for radioimmunoassay with regeneration of immunoadsorbent
US3959650A (en) * 1974-08-26 1976-05-25 Intelcom Rad Tech Method for detecting and identifying allergy
US4001583A (en) * 1974-10-04 1977-01-04 Barrett M James Covalently bound biological substances to plastic materials and use in radioassay
US4036946A (en) * 1975-10-20 1977-07-19 Marcos Kleinerman Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances
US4039652A (en) * 1973-10-11 1977-08-02 Miles Laboratories, Inc. Column method of immunoassay employing an immobilized binding partner
US4041146A (en) * 1975-05-01 1977-08-09 General Electric Company Method for detection of biological particles
US4067959A (en) * 1976-05-10 1978-01-10 International Diagnostic Technology, Inc. Indirect solid surface test for antigens or antibodies
US4090850A (en) * 1976-11-01 1978-05-23 E. R. Squibb & Sons, Inc. Apparatus for use in radioimmunoassays
US4133639A (en) * 1975-02-27 1979-01-09 International Diagnostic Technology, Inc. Test article including a covalently attached diagnostic reagent and method
US4144031A (en) * 1976-04-19 1979-03-13 International Radioimmune Systems, Inc. Cell test for detecting human chorionic gonadotropin
US4160016A (en) * 1977-05-16 1979-07-03 Syva Company Receptor fluorescent immunoassay
US4161515A (en) * 1973-10-02 1979-07-17 Syva Company Double receptor fluorescent immunoassay
DE2900546A1 (de) * 1978-01-26 1979-08-30 Miles Lab Spezifische bindungstest-verfahren
US4166844A (en) * 1977-04-18 1979-09-04 E. R. Squibb & Sons, Inc. Solid phase separation technique for use in radioimmunoassays
US4201763A (en) * 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
FR2438844A2 (fr) * 1978-10-12 1980-05-09 Int Diagnostic Tech Procede et appareil d'analyse quantitative par fluorometrie
US4207075A (en) * 1978-08-08 1980-06-10 Liburdy Robert P Rabbit immunoglobulin-N-(3-pyrene)-maleimide conjugate for fluorescent immunoassay
US4228127A (en) * 1978-10-06 1980-10-14 International Radioimmune Systems, Inc. Kit for detecting human chorionic gonadotropin
WO1980002201A1 (en) * 1979-04-09 1980-10-16 Minnesota Mining & Mfg Method for the assay of classes of antigen-specific antibodies
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays
US4254096A (en) * 1979-10-04 1981-03-03 Bio-Rad Laboratories, Inc. Reagent combination for solid phase immunofluorescent assay
US4256834A (en) * 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4273756A (en) * 1978-07-28 1981-06-16 Abbott Laboratories Immunoassay for class specific antibodies
US4289748A (en) * 1979-05-31 1981-09-15 United States Of America Ultrasensitive enzymatic radioimmunoassay method
US4331650A (en) * 1980-07-18 1982-05-25 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
USRE31006E (en) * 1968-09-24 1982-08-03 Akzona Incorporated Process for the demonstration and determination of reaction components having specific binding affinity for each other
US4343896A (en) * 1975-02-01 1982-08-10 Akzona Incorporated Method and test pack for the demonstration and determination of an antigen or antibody
US4357142A (en) * 1980-07-18 1982-11-02 Akzona Incorporated Glass support coated with synthetic polymer for bioprocess
US4373932A (en) * 1980-01-11 1983-02-15 Akzona Incorporated Application of water-dispersible hydrophobic dyes or pigments as labels in immunoassays
EP0106324A2 (en) * 1982-10-13 1984-04-25 Minnesota Mining And Manufacturing Company Fluorometric assay of allergic reactions and reagents therefor
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4486540A (en) * 1980-07-18 1984-12-04 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
FR2547057A1 (fr) * 1983-05-13 1984-12-07 Lofarma Farma Lab Procede pour fixer d'une facon stable des antigenes et des allergenes sur des supports solides, et supports destines a cet usage
WO1985002262A1 (en) * 1983-11-10 1985-05-23 Ventrex Laboratories, Inc. Multiple allergen-bearing matrixes useful for qualitative allergy screening
US4528267A (en) * 1982-11-26 1985-07-09 Axionics, Inc. Fluorometirc enzyme inhibition immunoassay for measuring potency of allergen extracts
US4621063A (en) * 1982-10-12 1986-11-04 The Center For Immunological Studies Methods for the detection and quantitation of immunological substances
US4629706A (en) * 1982-02-01 1986-12-16 Miles Laboratories, Inc. Method for determining allergic sensitivity
US4670383A (en) * 1984-09-13 1987-06-02 Boehringer Mannheim Gmbh Immune-chemical measurement process for haptens and proteins
WO1987003692A1 (en) * 1985-12-03 1987-06-18 Advanced Polymer Systems, Inc. Reaginic test for syphilis
US4677067A (en) * 1984-06-22 1987-06-30 Bio-Magnetech Corporation Magnetotactic bacteria in clinical assay, immunoassay, and cell separation procedures and the like
US4696907A (en) * 1980-07-18 1987-09-29 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
EP0245926A2 (en) * 1986-05-12 1987-11-19 Diagnostic Products Corporation Method of measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
US4845027A (en) * 1982-10-13 1989-07-04 Minnesota Mining And Manufacturing Company Fluorometric assay of allergic reactions
US4849337A (en) * 1983-01-31 1989-07-18 Minnesota Mining And Manufacturing Company Assaying allergen specific IgE levels with fluorogenic enzyme labeled antibody
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
US4891311A (en) * 1984-02-03 1990-01-02 Abbott Laboratories Stabilized enzyme conjugate composition
US4935339A (en) * 1985-05-07 1990-06-19 Nichols Institute Diagnostics Delayed solid phase immunologic assay
US5030558A (en) * 1986-11-07 1991-07-09 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
EP0451800A1 (en) * 1990-04-13 1991-10-16 Abbott Laboratories Binding of allergens to a solid phase
US5098846A (en) * 1987-05-27 1992-03-24 Mclean Hospital Solid phase protein assay by solid phase free site titration
US5132209A (en) * 1987-09-14 1992-07-21 Vanderbeeken Yves E Process for testing for maternal-fetal immunoincompatibility in pregnant women
US5156952A (en) * 1986-11-07 1992-10-20 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
US5232835A (en) * 1986-11-07 1993-08-03 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
US5244788A (en) * 1992-07-01 1993-09-14 Hubscher Thomas T Method and apparatus for performing determinations of immune rectants in biological fluids
US5429929A (en) * 1991-04-19 1995-07-04 The Trustees Of Columbia University In The City Of New York Method for detecting antibodies to a neuroblastoma antigen in mental illness
US5558869A (en) * 1992-12-30 1996-09-24 University Of Arkansas Major peanut allergen ara h II
US5561049A (en) * 1994-09-21 1996-10-01 Behringwerke Ag Method for detecting antibodies
US5622871A (en) * 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US5736343A (en) * 1995-08-18 1998-04-07 Landry; Donald Detection of organic compounds through regulation of antibody-catalyzed reactions
US5877028A (en) * 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
US5879951A (en) * 1997-01-29 1999-03-09 Smithkline Diagnostics, Inc. Opposable-element assay device employing unidirectional flow
US5939252A (en) * 1997-05-09 1999-08-17 Lennon; Donald J. Detachable-element assay device
US5998220A (en) * 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
US6187598B1 (en) 1987-04-27 2001-02-13 Conopco Inc. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US6271044B1 (en) 1998-05-06 2001-08-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method and kit for detecting an analyte
US6352862B1 (en) 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
EP1195606A1 (en) * 2000-10-03 2002-04-10 VBC-Genomics Forschungsges.m.b.H. Allergen-microarray assay
US20020168782A1 (en) * 2001-01-03 2002-11-14 Mccall Catherine A. Detection of allergen-specific IgE
US20030049237A1 (en) * 1996-09-23 2003-03-13 Bannon Gary A. Methods and reagents for decreasing clinical reaction to allergy
US20030129675A1 (en) * 1999-12-23 2003-07-10 Genentech, Inc. Assay method
US20030202980A1 (en) * 1995-12-29 2003-10-30 Caplan Michael J. Methods and reagents for decreasing clinical reaction to allergy
US20040208894A1 (en) * 2000-04-06 2004-10-21 Caplan Michael J Microbial delivery system
US6835824B1 (en) 1995-12-29 2004-12-28 University Of Arkansas Peanut allergens and methods
US6855508B2 (en) 1999-11-16 2005-02-15 Genentech, Inc. ELISA for VEGF
US20050063994A1 (en) * 2000-04-06 2005-03-24 Caplan Michael J. Methods and reagents for decreasing clinical reaction to allergy
US20050255527A1 (en) * 2004-05-15 2005-11-17 Genentech, Inc. Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
US20060099662A1 (en) * 2004-04-16 2006-05-11 Genentech, Inc. Assay for antibodies
US20060182716A1 (en) * 2004-08-09 2006-08-17 Jin Hong Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US20060204473A1 (en) * 2004-08-09 2006-09-14 Blatt Lawrence M Synthetic hyperglycosylated, and hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same
US20070161089A1 (en) * 2005-11-08 2007-07-12 Genentech, Inc. Method of Producing Pan-Specific Antibodies
WO2008060777A2 (en) 2006-10-04 2008-05-22 Genentech, Inc. Elisa for vegf
US20080171344A1 (en) * 2006-12-22 2008-07-17 Kapsner Kenneth P Methods, Kits and Materials for Diagnosing Disease States by Measuring Isoforms or Proforms of Myeloperoxidase
US7405084B1 (en) * 1997-12-30 2008-07-29 Phadia Ab Analytical method using particles and test kit for performing the method
WO2008150525A1 (en) 2007-06-04 2008-12-11 Genentech, Inc. Anti-notch1 nrr antibodies and methods using same
EP2014770A2 (en) 1997-10-29 2009-01-14 Genentech, Inc. WNT-1 Iinduced secreted polypeptide WISP-2
WO2009012256A1 (en) 2007-07-16 2009-01-22 Genentech, Inc. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
EP2033970A2 (en) 1997-10-29 2009-03-11 Genentech, Inc. WNT-1 inducible genes
EP2065467A2 (en) 2001-02-22 2009-06-03 Genentech, Inc. Anti-interferon-alpha antibodies
WO2010028277A1 (en) 2008-09-04 2010-03-11 Beckman Coulter, Inc. Pan-kinase activation and evaluation of signaling pathways
US20100166802A1 (en) * 2000-04-06 2010-07-01 Caplan Michael J Methods and reagents for decreasing clinical reaction to allergy
WO2010120561A1 (en) 2009-04-01 2010-10-21 Genentech, Inc. Anti-fcrh5 antibodies and immunoconjugates and methods of use
US7879977B2 (en) 1998-01-31 2011-02-01 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
EP2290086A2 (en) 2004-12-22 2011-03-02 Genentech, Inc. Methods for producing soluble multi-membrane-spanning proteins
WO2011028950A1 (en) 2009-09-02 2011-03-10 Genentech, Inc. Mutant smoothened and methods of using the same
US20110085981A1 (en) * 2008-04-08 2011-04-14 Huiru Wang Glycan-based drugs, therapies and biomarkers
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
WO2011079185A1 (en) 2009-12-23 2011-06-30 Genentech, Inc. Anti-bv8 antibodies and uses thereof
US20110183363A1 (en) * 2009-10-26 2011-07-28 Saloumeh Fischer Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis
WO2011153346A1 (en) 2010-06-03 2011-12-08 Genentech, Inc. Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
EP2402373A2 (en) 2006-01-05 2012-01-04 Genentech, Inc. Anti-EphB4 Antibodies and Methods Using Same
WO2012019024A2 (en) 2010-08-04 2012-02-09 Immunogen, Inc. Her3-binding molecules and immunoconjugates thereof
WO2012030738A2 (en) 2010-08-30 2012-03-08 Beckman Coulter, Inc. Complex phosphoprotein activation profiles
WO2012047968A2 (en) 2010-10-05 2012-04-12 Genentech, Inc. Mutant smoothened and methods of using the same
EP2446904A2 (en) 2006-05-30 2012-05-02 Genentech, Inc. Anti-CD22 antibodies, their immunoconjugates and uses thereof
EP2468772A2 (en) 2006-03-16 2012-06-27 Genentech, Inc. Antibodies to EGFL7 and methods for their use
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
EP2474557A2 (en) 2007-07-16 2012-07-11 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
WO2012149320A1 (en) 2011-04-29 2012-11-01 Bristol-Myers Squibb Company Ip-10 antibody dosage escalation regimens
WO2013078377A1 (en) 2011-11-23 2013-05-30 Igenica, Inc. Anti-cd98 antibodies and methods of use thereof
WO2013142796A2 (en) 2012-03-23 2013-09-26 Bristol-Myers Squibb Company Methods of treatments using ctla4 antibodies
WO2013148373A1 (en) 2012-03-28 2013-10-03 Genentech, Inc. Anti-hcmv idiotypic antibodies and uses thereof
EP2657253A2 (en) 2008-01-31 2013-10-30 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
WO2013169734A1 (en) 2012-05-07 2013-11-14 Amgen Inc. Anti-erythropoietin antibodies
US8609355B2 (en) 2011-07-26 2013-12-17 Indicator Systems International, Inc. Assays for the detection of microbes
WO2014059028A1 (en) 2012-10-09 2014-04-17 Igenica, Inc. Anti-c16orf54 antibodies and methods of use thereof
WO2014122166A1 (en) 2013-02-06 2014-08-14 Pieris Ag Novel lipocalin-mutein assays for measuring hepcidin concentration
WO2014160160A2 (en) 2013-03-13 2014-10-02 Novartis Ag Antibody drug conjugates
EP2845866A1 (en) 2006-10-27 2015-03-11 Genentech, Inc. Antibodies and immunoconjugates and uses therefor
EP2851372A1 (en) 2007-11-30 2015-03-25 Genentech, Inc. Anti-VEGF antibodies
WO2015120075A2 (en) 2014-02-04 2015-08-13 Genentech, Inc. Mutant smoothened and methods of using the same
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
WO2016024195A1 (en) 2014-08-12 2016-02-18 Novartis Ag Anti-cdh6 antibody drug conjugates
US9267939B2 (en) 2002-07-29 2016-02-23 Abbott Point Of Care Inc. Multiple hybrid immunoassay
WO2016075670A1 (en) 2014-11-14 2016-05-19 Novartis Ag Antibody drug conjugates
WO2016126972A1 (en) 2015-02-04 2016-08-11 Genentech, Inc. Mutant smoothened and methods of using the same
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
WO2016203432A1 (en) 2015-06-17 2016-12-22 Novartis Ag Antibody drug conjugates
WO2017040342A1 (en) 2015-08-28 2017-03-09 Genentech, Inc. Anti-hypusine antibodies and uses thereof
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WO2017106527A1 (en) 2015-12-15 2017-06-22 Case Western Reserve University Epithelial cancer evaluation using beta defensin
EP3196212A1 (en) 2010-02-24 2017-07-26 Immunogen, Inc. Immunoconjugates comprising a folate receptor 1 antibody
WO2017136558A1 (en) 2016-02-04 2017-08-10 Curis, Inc. Mutant smoothened and methods of using the same
WO2018136553A1 (en) 2017-01-18 2018-07-26 Genentech, Inc. Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof
WO2018142322A1 (en) 2017-02-03 2018-08-09 Novartis Ag Anti-ccr7 antibody drug conjugates
US10100121B2 (en) 2012-06-27 2018-10-16 Amgen Inc. Anti-mesothelin binding proteins
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WO2019106578A2 (en) 2017-12-01 2019-06-06 Novartis Ag Polyomavirus neutralizing antibodies
US10358497B2 (en) 2015-09-29 2019-07-23 Amgen Inc. Methods of treating cardiovascular disease with an ASGR inhibitor
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WO2019229699A1 (en) 2018-05-31 2019-12-05 Novartis Ag Hepatitis b antibodies
EP3620467A1 (en) 2010-03-12 2020-03-11 Debiopharm International SA Cd37-binding molecules and immunoconjugates thereof
WO2020053742A2 (en) 2018-09-10 2020-03-19 Novartis Ag Anti-hla-hbv peptide antibodies
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
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WO2021220199A1 (en) 2020-04-30 2021-11-04 Novartis Ag Ccr7 antibody drug conjugates for treating cancer
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WO2022081436A1 (en) 2020-10-15 2022-04-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods
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WO2022266659A1 (en) 2021-06-17 2022-12-22 Genentech, Inc. Anti-ubiquitination antibodies and methods of use

Cited By (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228660B1 (en) 1908-04-27 2001-05-08 Conopco Inc. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
USRE31006E (en) * 1968-09-24 1982-08-03 Akzona Incorporated Process for the demonstration and determination of reaction components having specific binding affinity for each other
US3857931A (en) * 1971-02-01 1974-12-31 Hoffmann La Roche Latex polymer reagents for diagnostic tests
US3852415A (en) * 1972-10-13 1974-12-03 Hoffmann La Roche Compositions for use in radioimmunoassay as a substitute for blood plasma extract in determination of carcinoembryonic antigen
US3896217A (en) * 1973-03-19 1975-07-22 Summa Corp Method and apparatus for radioimmunoassay with regeneration of immunoadsorbent
US4161515A (en) * 1973-10-02 1979-07-17 Syva Company Double receptor fluorescent immunoassay
US4039652A (en) * 1973-10-11 1977-08-02 Miles Laboratories, Inc. Column method of immunoassay employing an immobilized binding partner
US3959650A (en) * 1974-08-26 1976-05-25 Intelcom Rad Tech Method for detecting and identifying allergy
US4001583A (en) * 1974-10-04 1977-01-04 Barrett M James Covalently bound biological substances to plastic materials and use in radioassay
US4343896A (en) * 1975-02-01 1982-08-10 Akzona Incorporated Method and test pack for the demonstration and determination of an antigen or antibody
US4133639A (en) * 1975-02-27 1979-01-09 International Diagnostic Technology, Inc. Test article including a covalently attached diagnostic reagent and method
US4041146A (en) * 1975-05-01 1977-08-09 General Electric Company Method for detection of biological particles
US4201763A (en) * 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
US4036946A (en) * 1975-10-20 1977-07-19 Marcos Kleinerman Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances
US4144031A (en) * 1976-04-19 1979-03-13 International Radioimmune Systems, Inc. Cell test for detecting human chorionic gonadotropin
US4067959A (en) * 1976-05-10 1978-01-10 International Diagnostic Technology, Inc. Indirect solid surface test for antigens or antibodies
US4090850A (en) * 1976-11-01 1978-05-23 E. R. Squibb & Sons, Inc. Apparatus for use in radioimmunoassays
US4166844A (en) * 1977-04-18 1979-09-04 E. R. Squibb & Sons, Inc. Solid phase separation technique for use in radioimmunoassays
US4160016A (en) * 1977-05-16 1979-07-03 Syva Company Receptor fluorescent immunoassay
FR2445966A1 (fr) * 1978-01-26 1980-08-01 Miles Lab Procede de normalisation d'un constituant marque
DE2900546A1 (de) * 1978-01-26 1979-08-30 Miles Lab Spezifische bindungstest-verfahren
US4273756A (en) * 1978-07-28 1981-06-16 Abbott Laboratories Immunoassay for class specific antibodies
US4207075A (en) * 1978-08-08 1980-06-10 Liburdy Robert P Rabbit immunoglobulin-N-(3-pyrene)-maleimide conjugate for fluorescent immunoassay
US4228127A (en) * 1978-10-06 1980-10-14 International Radioimmune Systems, Inc. Kit for detecting human chorionic gonadotropin
FR2438844A2 (fr) * 1978-10-12 1980-05-09 Int Diagnostic Tech Procede et appareil d'analyse quantitative par fluorometrie
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays
US4256834A (en) * 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4236893A (en) * 1979-04-09 1980-12-02 Minnesota Mining And Manufacturing Company Method for the assay of classes of antigen-specific antibodies
WO1980002201A1 (en) * 1979-04-09 1980-10-16 Minnesota Mining & Mfg Method for the assay of classes of antigen-specific antibodies
US4289748A (en) * 1979-05-31 1981-09-15 United States Of America Ultrasensitive enzymatic radioimmunoassay method
US4254096A (en) * 1979-10-04 1981-03-03 Bio-Rad Laboratories, Inc. Reagent combination for solid phase immunofluorescent assay
US4373932A (en) * 1980-01-11 1983-02-15 Akzona Incorporated Application of water-dispersible hydrophobic dyes or pigments as labels in immunoassays
US4357142A (en) * 1980-07-18 1982-11-02 Akzona Incorporated Glass support coated with synthetic polymer for bioprocess
US4486540A (en) * 1980-07-18 1984-12-04 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
US4331650A (en) * 1980-07-18 1982-05-25 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
US4696907A (en) * 1980-07-18 1987-09-29 Science Research Center, Inc. Identification of reagins in the blood serum of allergen sensitized vertebrates
US4629706A (en) * 1982-02-01 1986-12-16 Miles Laboratories, Inc. Method for determining allergic sensitivity
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4621063A (en) * 1982-10-12 1986-11-04 The Center For Immunological Studies Methods for the detection and quantitation of immunological substances
EP0106324A3 (en) * 1982-10-13 1986-09-17 Minnesota Mining And Manufacturing Company Fluorometric assay of allergic reactions and reagents therefor
US4845027A (en) * 1982-10-13 1989-07-04 Minnesota Mining And Manufacturing Company Fluorometric assay of allergic reactions
EP0106324A2 (en) * 1982-10-13 1984-04-25 Minnesota Mining And Manufacturing Company Fluorometric assay of allergic reactions and reagents therefor
US4528267A (en) * 1982-11-26 1985-07-09 Axionics, Inc. Fluorometirc enzyme inhibition immunoassay for measuring potency of allergen extracts
US4849337A (en) * 1983-01-31 1989-07-18 Minnesota Mining And Manufacturing Company Assaying allergen specific IgE levels with fluorogenic enzyme labeled antibody
EP0131546A3 (en) * 1983-05-13 1987-02-04 Laboratorio Farmaceutico Lofarma S.R.L. Method for stably binding antigens and allergens to solid supports and supports obtained
FR2547057A1 (fr) * 1983-05-13 1984-12-07 Lofarma Farma Lab Procede pour fixer d'une facon stable des antigenes et des allergenes sur des supports solides, et supports destines a cet usage
EP0131546A2 (en) * 1983-05-13 1985-01-16 LABORATORIO FARMACEUTICO LOFARMA s.r.l. Method for stably binding antigens and allergens to polystyrene and supports obtained
WO1985002262A1 (en) * 1983-11-10 1985-05-23 Ventrex Laboratories, Inc. Multiple allergen-bearing matrixes useful for qualitative allergy screening
US4891311A (en) * 1984-02-03 1990-01-02 Abbott Laboratories Stabilized enzyme conjugate composition
US4677067A (en) * 1984-06-22 1987-06-30 Bio-Magnetech Corporation Magnetotactic bacteria in clinical assay, immunoassay, and cell separation procedures and the like
US4670383A (en) * 1984-09-13 1987-06-02 Boehringer Mannheim Gmbh Immune-chemical measurement process for haptens and proteins
US4935339A (en) * 1985-05-07 1990-06-19 Nichols Institute Diagnostics Delayed solid phase immunologic assay
US4738932A (en) * 1985-12-03 1988-04-19 Advanced Polymer Systems, Inc. Reaginic test for syphilis
WO1987003692A1 (en) * 1985-12-03 1987-06-18 Advanced Polymer Systems, Inc. Reaginic test for syphilis
EP0245926A3 (en) * 1986-05-12 1988-05-25 Diagnostic Products Corporation Method of measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
EP0245926A2 (en) * 1986-05-12 1987-11-19 Diagnostic Products Corporation Method of measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
US5030558A (en) * 1986-11-07 1991-07-09 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
US5156952A (en) * 1986-11-07 1992-10-20 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
US5232835A (en) * 1986-11-07 1993-08-03 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
US7109042B2 (en) 1987-04-27 2006-09-19 Inverness Medical Switzerland Gmbh Assays
US6818455B2 (en) 1987-04-27 2004-11-16 Inverness Medical Switzerland Gmbh Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US5622871A (en) * 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US6187598B1 (en) 1987-04-27 2001-02-13 Conopco Inc. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US5656503A (en) * 1987-04-27 1997-08-12 Unilever Patent Holdings B.V. Test device for detecting analytes in biological samples
US5098846A (en) * 1987-05-27 1992-03-24 Mclean Hospital Solid phase protein assay by solid phase free site titration
US5132209A (en) * 1987-09-14 1992-07-21 Vanderbeeken Yves E Process for testing for maternal-fetal immunoincompatibility in pregnant women
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
US5494830A (en) * 1987-10-21 1996-02-27 Hubscher; Thomas T. Methods for performing determinations of immune reactants in biological fluids
US7407813B2 (en) 1989-02-17 2008-08-05 Inverness Medical Switzerland Gmbh Assays
US6352862B1 (en) 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
US7238537B2 (en) 1989-02-17 2007-07-03 Inverness Medical Switzerland Gmbh Assays
US7384796B2 (en) 1989-02-17 2008-06-10 Inverness Medical Switzerland Gmbh Assays
US20030143755A1 (en) * 1989-02-17 2003-07-31 Davis Paul James Assays
EP0451800A1 (en) * 1990-04-13 1991-10-16 Abbott Laboratories Binding of allergens to a solid phase
US5091318A (en) * 1990-04-13 1992-02-25 Abbott Laboratories Binding of allergens to a solid phase
US5429929A (en) * 1991-04-19 1995-07-04 The Trustees Of Columbia University In The City Of New York Method for detecting antibodies to a neuroblastoma antigen in mental illness
US5998220A (en) * 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
US6017767A (en) * 1991-05-29 2000-01-25 Beckman Coulter, Inc. Assay device
US5877028A (en) * 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
US5244788A (en) * 1992-07-01 1993-09-14 Hubscher Thomas T Method and apparatus for performing determinations of immune rectants in biological fluids
US5973121A (en) * 1992-12-30 1999-10-26 University Of Arkansas Immunoassay for peanut allergen
US6441142B1 (en) 1992-12-30 2002-08-27 University Of Arkansas Immunoassay for peanut allergen
US5558869A (en) * 1992-12-30 1996-09-24 University Of Arkansas Major peanut allergen ara h II
US5561049A (en) * 1994-09-21 1996-10-01 Behringwerke Ag Method for detecting antibodies
US5736343A (en) * 1995-08-18 1998-04-07 Landry; Donald Detection of organic compounds through regulation of antibody-catalyzed reactions
US20030202980A1 (en) * 1995-12-29 2003-10-30 Caplan Michael J. Methods and reagents for decreasing clinical reaction to allergy
US6835824B1 (en) 1995-12-29 2004-12-28 University Of Arkansas Peanut allergens and methods
US20030049237A1 (en) * 1996-09-23 2003-03-13 Bannon Gary A. Methods and reagents for decreasing clinical reaction to allergy
US7485708B2 (en) 1996-09-23 2009-02-03 University Of Arkansas Nucleic acids encoding ara h 3 polypeptides
US5879951A (en) * 1997-01-29 1999-03-09 Smithkline Diagnostics, Inc. Opposable-element assay device employing unidirectional flow
US5939252A (en) * 1997-05-09 1999-08-17 Lennon; Donald J. Detachable-element assay device
EP2014770A2 (en) 1997-10-29 2009-01-14 Genentech, Inc. WNT-1 Iinduced secreted polypeptide WISP-2
EP2033970A2 (en) 1997-10-29 2009-03-11 Genentech, Inc. WNT-1 inducible genes
US7405084B1 (en) * 1997-12-30 2008-07-29 Phadia Ab Analytical method using particles and test kit for performing the method
US7879977B2 (en) 1998-01-31 2011-02-01 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
US6271044B1 (en) 1998-05-06 2001-08-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method and kit for detecting an analyte
US6855508B2 (en) 1999-11-16 2005-02-15 Genentech, Inc. ELISA for VEGF
US7541160B2 (en) 1999-11-16 2009-06-02 David Tai Wai Fei ELISA for VEGF
US20070202558A1 (en) * 1999-11-16 2007-08-30 Genentech, Inc. ELISA for VEGF
US20060234306A1 (en) * 1999-12-23 2006-10-19 Genentech, Inc. Assay method
US20050233387A1 (en) * 1999-12-23 2005-10-20 Genentech, Inc. Assay method
US20030129675A1 (en) * 1999-12-23 2003-07-10 Genentech, Inc. Assay method
US8815251B2 (en) 2000-04-06 2014-08-26 Allertein Therapeutics, Llc Microbial delivery system
US20100166802A1 (en) * 2000-04-06 2010-07-01 Caplan Michael J Methods and reagents for decreasing clinical reaction to allergy
US8246945B2 (en) 2000-04-06 2012-08-21 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
US8153414B2 (en) 2000-04-06 2012-04-10 Allertein Therapeutics, Llc Microbial delivery system
US20050063994A1 (en) * 2000-04-06 2005-03-24 Caplan Michael J. Methods and reagents for decreasing clinical reaction to allergy
US20040234548A1 (en) * 2000-04-06 2004-11-25 Caplan Michael J. Microbial delivery system
US20040208894A1 (en) * 2000-04-06 2004-10-21 Caplan Michael J Microbial delivery system
US20050101031A1 (en) * 2000-10-03 2005-05-12 Reinhard Hiller Allergen-microarray assay
CN1325919C (zh) * 2000-10-03 2007-07-11 Vbc-基因组生物科学研究股份公司 过敏原微阵列分析
WO2002029415A1 (en) * 2000-10-03 2002-04-11 Vbc-Genomics Bioscience Research Gmbh Allergen-microarray assay
EP1195606A1 (en) * 2000-10-03 2002-04-10 VBC-Genomics Forschungsges.m.b.H. Allergen-microarray assay
US20080139406A1 (en) * 2000-10-03 2008-06-12 Reinhard Hiller Allergen-Microarray Assay
US20020168782A1 (en) * 2001-01-03 2002-11-14 Mccall Catherine A. Detection of allergen-specific IgE
US20050214866A1 (en) * 2001-01-03 2005-09-29 Mccall Catherine A Detection of allergen-specific IgE
EP2292301A2 (en) 2001-02-22 2011-03-09 Genentech, Inc. Anti-interferon-alpha antibodies
EP2065467A2 (en) 2001-02-22 2009-06-03 Genentech, Inc. Anti-interferon-alpha antibodies
US9267939B2 (en) 2002-07-29 2016-02-23 Abbott Point Of Care Inc. Multiple hybrid immunoassay
US9995744B2 (en) 2002-07-29 2018-06-12 Abbott Point Of Care Inc. Multiple hybrid immunoassay
US10641767B2 (en) 2002-07-29 2020-05-05 Abbott Point Of Care Inc. Multiple hybrid immunoassay
US20080176257A9 (en) * 2004-04-16 2008-07-24 Genentech, Inc. Assay for Antibodies
US20060099662A1 (en) * 2004-04-16 2006-05-11 Genentech, Inc. Assay for antibodies
US20070015228A1 (en) * 2004-04-16 2007-01-18 Genentech, Inc. Assay for Antibodies
US20050255527A1 (en) * 2004-05-15 2005-11-17 Genentech, Inc. Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
US7514223B2 (en) 2004-05-15 2009-04-07 Genentech, Inc. Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
US20100099851A1 (en) * 2004-08-09 2010-04-22 Alios Biopharma, Inc. Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US20060182716A1 (en) * 2004-08-09 2006-08-17 Jin Hong Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US20060204473A1 (en) * 2004-08-09 2006-09-14 Blatt Lawrence M Synthetic hyperglycosylated, and hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
EP2290086A2 (en) 2004-12-22 2011-03-02 Genentech, Inc. Methods for producing soluble multi-membrane-spanning proteins
EP2290088A1 (en) 2004-12-22 2011-03-02 Genentech, Inc. Methods for producing soluble multi-menbrane-spanning proteins
EP2290087A2 (en) 2004-12-22 2011-03-02 Genentech, Inc. Methods for producing soluble multi-membrane-spanning proteins
US20070161089A1 (en) * 2005-11-08 2007-07-12 Genentech, Inc. Method of Producing Pan-Specific Antibodies
EP3156418A1 (en) 2006-01-05 2017-04-19 Genentech, Inc. Anti-ephb4 antibodies and methods using same
EP2402373A2 (en) 2006-01-05 2012-01-04 Genentech, Inc. Anti-EphB4 Antibodies and Methods Using Same
EP2093235A1 (en) 2006-02-08 2009-08-26 Alios Biopharma Inc. Hyperglycosylated variants of interferon alfacon-1
EP2468772A2 (en) 2006-03-16 2012-06-27 Genentech, Inc. Antibodies to EGFL7 and methods for their use
EP2447282A2 (en) 2006-05-30 2012-05-02 Genentech, Inc. Anti-CD22 Antibodies, their Immunoconjugates and uses thereof
EP2446904A2 (en) 2006-05-30 2012-05-02 Genentech, Inc. Anti-CD22 antibodies, their immunoconjugates and uses thereof
WO2008060777A2 (en) 2006-10-04 2008-05-22 Genentech, Inc. Elisa for vegf
EP2457929A1 (en) 2006-10-04 2012-05-30 Genentech, Inc. ELISA for VEGF
EP3103812A1 (en) 2006-10-04 2016-12-14 Genentech, Inc. Elisa for vegf
EP2845866A1 (en) 2006-10-27 2015-03-11 Genentech, Inc. Antibodies and immunoconjugates and uses therefor
US20080171344A1 (en) * 2006-12-22 2008-07-17 Kapsner Kenneth P Methods, Kits and Materials for Diagnosing Disease States by Measuring Isoforms or Proforms of Myeloperoxidase
WO2008150525A1 (en) 2007-06-04 2008-12-11 Genentech, Inc. Anti-notch1 nrr antibodies and methods using same
EP2641618A2 (en) 2007-07-16 2013-09-25 Genentech, Inc. Humanized anti-CD79B antibodies and immunoconjugates and methods of use
EP2474557A2 (en) 2007-07-16 2012-07-11 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
WO2009012256A1 (en) 2007-07-16 2009-01-22 Genentech, Inc. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
EP2502937A2 (en) 2007-07-16 2012-09-26 Genentech, Inc. Anti-CD 79b Antibodies And Immunoconjugates And Methods Of Use
EP2851372A1 (en) 2007-11-30 2015-03-25 Genentech, Inc. Anti-VEGF antibodies
EP3173425A1 (en) 2007-11-30 2017-05-31 Genentech, Inc. Anti-vegf antibodies
EP4427805A2 (en) 2008-01-31 2024-09-11 Genentech, Inc. Anti-cd79b antibodies and immunoconjugates and methods of use
EP2657253A2 (en) 2008-01-31 2013-10-30 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
US11285166B2 (en) 2008-04-08 2022-03-29 B&H Biotechnologies, Llc Glycan-based drugs, therapies and biomarkers
US20110085981A1 (en) * 2008-04-08 2011-04-14 Huiru Wang Glycan-based drugs, therapies and biomarkers
US10342812B2 (en) 2008-04-08 2019-07-09 B&H Biotechnologies, Llc Glycan-based drugs, therapies and biomarkers
US9119866B2 (en) * 2008-04-08 2015-09-01 Huiru Wang Glycan-based drugs, therapies and biomarkers
WO2010028277A1 (en) 2008-09-04 2010-03-11 Beckman Coulter, Inc. Pan-kinase activation and evaluation of signaling pathways
WO2010120561A1 (en) 2009-04-01 2010-10-21 Genentech, Inc. Anti-fcrh5 antibodies and immunoconjugates and methods of use
WO2011028950A1 (en) 2009-09-02 2011-03-10 Genentech, Inc. Mutant smoothened and methods of using the same
US20110183363A1 (en) * 2009-10-26 2011-07-28 Saloumeh Fischer Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis
US9315583B2 (en) 2009-10-26 2016-04-19 Genentech, Inc. Assays for detecting antibodies specific to therapeutic anti-IgE antibodies and their use in anaphylaxis
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
WO2011079185A1 (en) 2009-12-23 2011-06-30 Genentech, Inc. Anti-bv8 antibodies and uses thereof
EP3196212A1 (en) 2010-02-24 2017-07-26 Immunogen, Inc. Immunoconjugates comprising a folate receptor 1 antibody
EP3620467A1 (en) 2010-03-12 2020-03-11 Debiopharm International SA Cd37-binding molecules and immunoconjugates thereof
WO2011153346A1 (en) 2010-06-03 2011-12-08 Genentech, Inc. Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
US8771966B2 (en) 2010-06-03 2014-07-08 Genentech, Inc. Immuno-PET imaging of antibodies and immunoconjugates and uses therefor
WO2012019024A2 (en) 2010-08-04 2012-02-09 Immunogen, Inc. Her3-binding molecules and immunoconjugates thereof
WO2012030738A2 (en) 2010-08-30 2012-03-08 Beckman Coulter, Inc. Complex phosphoprotein activation profiles
WO2012047968A2 (en) 2010-10-05 2012-04-12 Genentech, Inc. Mutant smoothened and methods of using the same
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
WO2012149320A1 (en) 2011-04-29 2012-11-01 Bristol-Myers Squibb Company Ip-10 antibody dosage escalation regimens
US8609355B2 (en) 2011-07-26 2013-12-17 Indicator Systems International, Inc. Assays for the detection of microbes
WO2013078377A1 (en) 2011-11-23 2013-05-30 Igenica, Inc. Anti-cd98 antibodies and methods of use thereof
WO2013142796A2 (en) 2012-03-23 2013-09-26 Bristol-Myers Squibb Company Methods of treatments using ctla4 antibodies
US20130266973A1 (en) * 2012-03-28 2013-10-10 Genentech, Inc. Idiotypic antibodies and uses thereof
WO2013148373A1 (en) 2012-03-28 2013-10-03 Genentech, Inc. Anti-hcmv idiotypic antibodies and uses thereof
US9139659B2 (en) * 2012-03-28 2015-09-22 Genentech, Inc. Idiotypic antibodies and uses thereof
US10513556B2 (en) 2012-05-07 2019-12-24 Amgen Inc. Anti-erythropoietin antibodies
US9441039B2 (en) 2012-05-07 2016-09-13 Amgen Inc. Anti-erythropoietin antibodies
WO2013169734A1 (en) 2012-05-07 2013-11-14 Amgen Inc. Anti-erythropoietin antibodies
US10919975B2 (en) 2012-06-27 2021-02-16 Amgen Inc. Anti-mesothelin binding proteins
US11866508B2 (en) 2012-06-27 2024-01-09 Amgen Inc. Anti-mesothelin binding proteins
US10100121B2 (en) 2012-06-27 2018-10-16 Amgen Inc. Anti-mesothelin binding proteins
WO2014059028A1 (en) 2012-10-09 2014-04-17 Igenica, Inc. Anti-c16orf54 antibodies and methods of use thereof
WO2014122166A1 (en) 2013-02-06 2014-08-14 Pieris Ag Novel lipocalin-mutein assays for measuring hepcidin concentration
EP3888671A2 (en) 2013-03-11 2021-10-06 Amgen Inc. Protein formulations
WO2014160160A2 (en) 2013-03-13 2014-10-02 Novartis Ag Antibody drug conjugates
EP3514178A1 (en) 2013-03-15 2019-07-24 Novartis AG Antibody drug conjugates
US10151754B2 (en) 2014-01-17 2018-12-11 Minomic International Ltd. Cell surface prostate cancer antigen for diagnosis
EP3738981A1 (en) 2014-01-24 2020-11-18 NGM Biopharmaceuticals, Inc. Antibodies binding beta klotho domain 2 and methods of use thereof
WO2015120075A2 (en) 2014-02-04 2015-08-13 Genentech, Inc. Mutant smoothened and methods of using the same
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
WO2016024195A1 (en) 2014-08-12 2016-02-18 Novartis Ag Anti-cdh6 antibody drug conjugates
WO2016075670A1 (en) 2014-11-14 2016-05-19 Novartis Ag Antibody drug conjugates
WO2016126972A1 (en) 2015-02-04 2016-08-11 Genentech, Inc. Mutant smoothened and methods of using the same
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
WO2016203432A1 (en) 2015-06-17 2016-12-22 Novartis Ag Antibody drug conjugates
EP3932953A1 (en) 2015-08-28 2022-01-05 F. Hoffmann-La Roche AG Anti-hypusine antibodies and uses thereof
WO2017040342A1 (en) 2015-08-28 2017-03-09 Genentech, Inc. Anti-hypusine antibodies and uses thereof
EP4414385A2 (en) 2015-09-16 2024-08-14 Novartis AG Polyomavirus neutralizing antibodies
WO2017046676A1 (en) 2015-09-16 2017-03-23 Novartis Ag Polyomavirus neutralizing antibodies
US10358497B2 (en) 2015-09-29 2019-07-23 Amgen Inc. Methods of treating cardiovascular disease with an ASGR inhibitor
US11066472B2 (en) 2015-09-29 2021-07-20 Amgen Inc. Methods of treating cardiovascular disease with an anti-ASGR antibody or binding fragments thereof
EP4435105A2 (en) 2015-09-29 2024-09-25 Amgen Inc. Asgr inhibitors for reduzing cholesterol levels
WO2017106527A1 (en) 2015-12-15 2017-06-22 Case Western Reserve University Epithelial cancer evaluation using beta defensin
US10816549B2 (en) 2015-12-15 2020-10-27 Case Western Reserve University Epithelial cancer evaluation using beta defensin
WO2017136558A1 (en) 2016-02-04 2017-08-10 Curis, Inc. Mutant smoothened and methods of using the same
WO2018136553A1 (en) 2017-01-18 2018-07-26 Genentech, Inc. Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof
US11279762B2 (en) 2017-01-18 2022-03-22 Genentech, Inc. Idiotypic antibodies against anti-PD-L1 antibodies and uses thereof
WO2018142322A1 (en) 2017-02-03 2018-08-09 Novartis Ag Anti-ccr7 antibody drug conjugates
WO2019106578A2 (en) 2017-12-01 2019-06-06 Novartis Ag Polyomavirus neutralizing antibodies
US11932681B2 (en) 2018-05-31 2024-03-19 Novartis Ag Hepatitis B antibodies
WO2019229699A1 (en) 2018-05-31 2019-12-05 Novartis Ag Hepatitis b antibodies
WO2020053742A2 (en) 2018-09-10 2020-03-19 Novartis Ag Anti-hla-hbv peptide antibodies
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
WO2020128863A1 (en) 2018-12-19 2020-06-25 Novartis Ag Anti-tnf-alpha antibodies
EP4406555A2 (en) 2018-12-21 2024-07-31 Novartis AG Antibodies to pmel17 and conjugates thereof
WO2020128612A2 (en) 2018-12-21 2020-06-25 Novartis Ag Antibodies to pmel17 and conjugates thereof
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WO2021220199A1 (en) 2020-04-30 2021-11-04 Novartis Ag Ccr7 antibody drug conjugates for treating cancer
WO2021247457A2 (en) 2020-06-01 2021-12-09 Genentech, Inc. Methods for making extracellular vesicles and uses thereof
WO2022081436A1 (en) 2020-10-15 2022-04-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods
WO2022087274A1 (en) 2020-10-21 2022-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies that neutralize type-i interferon (ifn) activity
WO2022178255A2 (en) 2021-02-19 2022-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies that neutralize sars-cov-2
WO2022266659A1 (en) 2021-06-17 2022-12-22 Genentech, Inc. Anti-ubiquitination antibodies and methods of use

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