US3714943A - Medicament injectors - Google Patents

Medicament injectors Download PDF

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Publication number
US3714943A
US3714943A US00093982A US3714943DA US3714943A US 3714943 A US3714943 A US 3714943A US 00093982 A US00093982 A US 00093982A US 3714943D A US3714943D A US 3714943DA US 3714943 A US3714943 A US 3714943A
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Prior art keywords
medicament
housing
chamber
injector
gas
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US00093982A
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English (en)
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H Yanof
B Pansky
J Poff
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A61M2005/005—Magazines with multiple ampoules directly inserted into an injection or infusion device, e.g. revolver-like magazines containing ampoules with or without needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems
    • A61M2205/6081—Colour codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/001—Apparatus specially adapted for cleaning or sterilising syringes or needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing

Definitions

  • the present invention is directed toward the art of hypodermic injectors and, more particularly, to improved injectors of the type by which medicament can be injected without the use of a skin-piercing needle.
  • velocity injectors which inject medicament by use of a high velocity jet without a skin-piercing needle are well known and often referred to as velocity injectors. Such velocity injectors are often used in mass innoculations. They have not, however, been widely used for giving individual shots on a limited basis, such as in doctors and dentists offices, or by diabetics in their homes.
  • the present invention overcomes the abovediscussed problems and provides a simple and highly reliable velocity injector.
  • Injectors formed in accordance with the invention are highly reliable, compact, and safe to use.
  • an injector having a first body portion including a medicament receiving chamber and an orifice through which the medicament can be ejected.
  • the chamber includes at least one movable wall portion through which pressure can be applied to medicament in the chamber to cause it to be ejected through the orifice at a velocity sufficient to enter tissues without use of a needle.
  • a second body portion including housing means for carrying a plurality of medicament ampules and a plurality of cartridges holding a propellant gas under substantial pressure.
  • Passage means including valve means connect between the housing means and the first body portion to controllably supply medicament and pressurizing gas to the chamber on opposite sides of the movable wall.
  • indexing means are provided for permitting movement of the housing means relative to the first body to bring selected ones of said ampules and capsules into flow relationship with the passages.
  • the housing means also includes a container of cleaning solution which can be indexed into alignment with the passage means for flushing at least the medicament receiving chamber.
  • the housing means is preferably rotatable relative to the first body portion and provided with means for preventing inadvertent actuation of the cleaning solution.
  • the gas cartridge used with the cleaning solution is under a pressure sufficiently low so that injection cannot take place.
  • a velocity injector including a first housing adapted to hold a medicament ampule and propellant gas cartridge. Carried by the housing and movable relative thereto is a second housing including a medicament chamber having a movable wall portion and an outlet orifice through which medicament can be ejected. Means are provided for supplying pressurized gas to a position behind the movable wall portion including a passageway extending through the second housing. Associated with the second housing are means to prevent pressurizing gas from flowing through the passageway except upon movement of the second housing relative to the first housing in a direction toward the outlet orifice.
  • the arrangement of the housing portions is such that the user merely presses the outlet against the skin causing movement of the second housing relative to the first to thereby release pressurized gas and produce an injection. It is not necessary to consciously press an actuating lever, button, or the like. This is advantageous for persons such as diabetics who must give themselves shots.
  • FIG. I is a longitudinal, cross-sectional view through a preferred embodiment of injector formed in accordance with the invention.
  • FIG. 2 is a cross-sectional view taken on line 22 of FIG. 1;
  • FIG. 3 is a view taken on line 3-3 of FIG. 1 and showing the actuating knob for valve assembly of the FIG. I embodiment;
  • FIG. 4 is pictorial view of a typical medicament or pressurizing gas cartridge used in the preferred form of the invention.
  • FIG. 5 is a pictorial, somewhat schematic, showing of the rotary slide valve assembly used in the FIG. 1 embodiment
  • FIGS. 6A and 6B are views taken on line 6-6 of FIG. 5 and showing the valve connections in the fill and fire settings, respectively, of the actuating knob;
  • FIG. 7 is a cross-sectional view taken on line 7-7 of FIG. 1;
  • FIG. 8 is a cross-sectional view through a modified form of the invention.
  • FIG. 9 is a view taken on line 9'-9 of FIG. 8;
  • FIG. 10 is a pictorial view of the valve assembly of the FIGS. Sand 9 embodiment.
  • FIG. 1 shows the preferred overall arrangement of an-injector including a controllable volume injection assembly 10, a medicament and actuating fluid supply assembly 12, and an actuating and control valve assembly 14 which serves to regulate flow between assemblies and 12.
  • assembly A is shown somewhat larger than actual size; however, the specific size and/or configuration of the assembly could vary substantially within the scope of the invention. For this reason, the invention is not to be assumed as limited to the specific details shown.
  • All of the assemblies l0, l2 and 14 are preferably carried in a common housing or body forming member 16 which can be formed from any suitable material such as aluminum, stainless steel, certain plastics and ceramics.
  • the controllable volume injection assembly 10 is carried within the forward end of the body 16 and includes a cylindrical chamber 18 formed inwardly from the lower surface of body 16.
  • the chamber 18 is formed inwardly from the lower surface of body 16 and, at its inlet end, has enlarged threaded bore portion 20.
  • a threaded plug 22 Positioned within bore 20 is a threaded plug 22 having an outwardly extending threaded sleeve 24.
  • the inner face of plug 22 is provided with a tapered bore 26 which extends inwardly from the inner face in alignment with the axis of chamber 18.
  • Connected to the outwardly extending sleeve 24 is an injection nozzle 28.
  • the chamber and all passageways are formed from material or lined with material to provide a non-wettable surface.
  • Nozzle 28 can be formed in many different configurations and have outlet orifices of different sizes depending, for example, upon the particular type of injection to be given.
  • the nozzle 28 merely comprises a machined body portion provided with a tapered opening 30 which is aligned with the opening 26 and terminating in an outlet orifice 32.
  • the outlet orifice 32 is formed in a nylon bushing 34 which is press-fitted in the nozzle and sealed with an O-ring.” This allows a common nozzle body to have many different orifice sizes.
  • a movable wall means in the form of a piston member 36 which divides the chamber into a medicament chamber portion 38 and a pressurizing gas chamber portion 40.
  • the piston 36 can be formed from any suitable material but is shown as a plastic or polymeric material such I as polyethylene, polypropylene.
  • the piston is mounted for sealed, sliding movement within the cylindrical chamber 18. Its upward limit of movement is adjustably controlled so as to allow the volume of the medicament chamber 38 to be varied as desired. In the embodiment under consideration, adjustment is controlled by a threaded stud member 42.
  • stud 42 is threaded in an opening 44 formed inwardly from the upper surface of the body 16 in alignment with the chamber 18.
  • the upper limit of travel of piston 36 can be varied to thereby vary the quantity of medicament that can be held in chamber
  • high pressure fluid preferably gas
  • the piston will be movedupward into engagement with the lower end of stud 44.
  • high pressure fluid preferably gas
  • the gas pressure is supplied at a level such that the medicament discharged from nozzle 32 has a velocity sufficient to penetrate the patients skin tissue or muscle to the depth desired.
  • the nozzle or orifice size as well as the number of orifices can be varied depending upon the particular type of injection being given and the particular desired end-effect.
  • the assembly 12 could take many forms but, in the preferred embodiment, comprises a movable housing which can be indexed to bring different gas cartridges and medicament containers or ampules into proper position.
  • the housing comprises a rotatable cylinder 48 having a multiple number of axially extending openings formed therein.
  • the openings and their relationship will be described more fully hereafter but, for present purposes, it is sufficient to note that they are designed to hold small sealed cartridges of high pressure gas and ampules of medicament.
  • the individual ampules are received within the openings and can be connected through the valve assembly 14 with the medicament chamber 38 and the gas chamber 40 by the valve assembly 14.
  • FIG. 4 shows a typical cylindrical-ampule or cartridge of the type which is to be used in the unit.
  • the cylinder 48 has two concentric rows of axially extending openings.
  • An outer row preferably somewhat larger in diameter than the inner row, has seven openings 50 of uniform diameter adapted to hold pressurizing gas cartridges.
  • the inner row of openings has a plurality of openings, for example seven, each of a uniform first diameter arranged to hold similar medicament ampules which are somewhat larger or smaller than the gas pressure cartridges.
  • the openings could be of a uniform size for both gas and medication, the arrangement shown is preferred since it prevents in advertent placing of a gas cartridge within a medicament opening.
  • Opening 54 in the inner row can be utilized for holding a containers or cartridge of cleaning fluid such as buffered physiological salt solution with an added disinfectant or the like.
  • the outer large diameter opening 54 is used for a pressurizing gas cartridge of somewhat larger diameter but lower pressure.
  • the opening 53 is of a larger diameter than the openings 52 so that the cleaning fluid cannot be placed by mistake into a medicament chamber. Further, the use of a larger diameter opening 54 prevents use of a high pressure cartridge so that cleaning fluid cannot be expelled at a velocity sufficient to produce an injection.
  • the described variation in chamber openings is preferred for preventing inadvertent injection of cleaning fluid, other methods could be used. For example, different chamber shapes, color coding, etc.
  • the cylinder 48 is mounted for rotation on a hollow, threaded stud or shaft 56 which is threaded into the body 16.
  • the body 16 has an axially extending circumferential flange portion 58 which surrounds the cylinder 48 while allowing it to be freely rotatable therein.
  • the inner end the cylinder 48 is provided with a cover plate member 60 which is releasably connected to the cylinder by a threaded retainer sleeve 62.
  • the cover plate 60 engages the inner ends of the cartridges and prevents them from moving to the left in the cylinder during an indexing motion which will subsequently be described.
  • the cover plate 60 has openings slightly smaller than the corresponding openings 50, 52, 53 and 54.
  • means are provided to allow the ampules and cartridges to be punctured and connected in flow relationship with the valve assembly 14.
  • these means comprise hollow needle-like members 62 and 64 carried, respectively, in bores 66 and 68.
  • Needle member 62 is mounted in a threaded member 69 and connects from the valve assembly 14 to the needle end portion 62.
  • the needle portion 64 is carried in a threaded member 70. As shown, the inner ends of the cartridges and ampules are punctured as they are moved toward the needles.
  • the means for controlling rotation and movement of the cylinder 40 comprises a retractable indexing mechanism which includes an outer cup-shaped cover member 72 which is connected to and moves with cylinder 48.
  • Cover member 72 includes an end wall 73 and a sleeve or wall portion 74.
  • the side wall portion 74 closely surrounds the outer circumference of the rearwardly extending sleeve 58 on body 16.
  • the end wall is releasably connected to an internal stud member 76 by screw 75.
  • Stud 76 is slidably received within the outer end of the shaft 56. Note that the stud 76 has a flange portion 78 which is closely received within the center of the shaft 56.
  • a compression spring 80 is positioned between the flange 78 and the inwardly extending flange 81 so as to main tain the stud continually biased to the left to pull the cylinder 48 inwardly.
  • a snap-ring 82 is positioned on the outer end of stud 76. Accordingly, the screw 75 can be removed to remove the cup-shaped member 74 and the cylinder for access to the outer ends of the ampule and cartridge holding openings. The snap-ring prevents the stud from sliding within the center of shaft 56.
  • pin member 84 which is carried on the inner face of end wall 73.
  • Pin 84 is adapted to be received within the openings 86 (see FIG. 7) formed in the end of the sleeve 58. It should be noted that the openings 84 are aligned with the rows of medicament and gas receiving openings of cylinder 48. To index the cylinder 48 to bring a new set of cartridges into alignment with the pins or needles 62, 64, it is only necessary to retract the cup-shaped member 72 to the dotted line position of FIG. 1.
  • the needle 84 is free of the end of I sleeve 48 and the assembly can be rotated until the pin 84 is in alignment with the next opening 84.
  • the cylinder 48 and the cup-shaped end member 72 can then be pushed to the left causing the new cartridges to be punctured by the needles 62 and 64.
  • the preferred valving arrangement is comprised of a rotary slide valve member 90 which is carried within a bore 92 formed intermediate the sections 10 and 12.
  • the slide valve member 90 is cylindrical and includes a central, somewhat large diameter section 94 and reduced diameters end sections 96 and 98. Suitable passages which will be subsequently described in detail are formed through the central portion 90 to provide connection with the gas and medicament passages.
  • the lower reduced diameter end portion 98 of the valve member is slidably and rotatably received within a plug member 100 threaded into an enlarged diameter bore 102 formed in the lower surface of the body 16.
  • a flange 104 is slidably received within the bore 102 and a compression spring 106 is positioned between the inner face of the threaded member 100 and the flange 104. Flange 104 engages the shoulder between sections 90 and 98 of the valve member. Accordingly, the valve member is normally biased to the upper position shown solid in FIG. 1.
  • valve member 90 The upper reduced diameter end 96 of valve member 90 is provided with a knob or the like 108 which is releasably connected to portion 96 in any convenient manner such as through the use of a set screw 110.
  • the valve 92 can be rotated by knob 108 and, further, by pushing downward on knob 108, the valve can be moved downwardly against the bias of spring 106.
  • This particular arrangement allows various selected passages between the sections 10 and 12 to be connected in desired manners.
  • the lower end of valve member 92 is slotted as shown at 93 in FIGS. 1 and 5.
  • a corresponding fin is carried in plug so that the valve member can be pushed down only when the fin and slot are in alignment, which is in the fire position.
  • a spring biased detent plunger 111 which engages recesses formed under the knob 110. As the knob is rotated between various positions, the detent plunger provides an indication of proper positioning of the knob.
  • FIGS. 3, 5, 6A and 63 best illustrate the arrangement of the passages which permits control of the flow of gas and medicament to the injection section l0.
  • the valve assembly 14 connects the needle 62 with passage 112 to permit medicament to be supplied to the medicament chamber portion 38 of chamber 18.
  • the valve controls the supply of pressurizing gas from needle 64 to passage 114 and the connecting which leads to the lower end of the slide valve member 92.
  • a corresponding passage 120 is formed through the member 100.
  • the gas pressure chamber is connected with atmosphere so as to relieve any internal pressures within the chamber.
  • the valve member 92 also includes a cross passage 122 which is positioned at a 45 angle relative to passage 117.
  • the valve when the valve is rotated so that the indicator arrow 124 points to the fill position, passage 122 is in alignment with passages 112 and needle 62. Accordingly, medicament can flow from the medicament capsule into the medicament chamber portion 38.
  • the medicament in the capsule is under a slight pressure so as to cause it to be expelled from the capsule to raise the piston 36 into engagement with the lower end of stud 42 thereby filling the chamber.
  • valve assembly controls all filling and firing operations of the unit.
  • the gas pressure within the ampule positioned in chamber 54 is substantially less than that required to produce an injection. This eliminates the possibility that cleaning solution could be injected accidentally.
  • the outer circumference of the sleeve 74 and 58 can be suitably marked with indicia to indicate the presence of cleaning cartridges in alignment with the needles 62, 64.
  • FIGS 8 and 9 illustrate a modified form of the invention which utilizes a substantial different injector assembly and which can use the same type of indexable supply chamber if desired; however, it is shown with a simple supply section which holds only one medicament ampule and one gas pressure ampule.
  • the embodiment of FIGS. 8 and 9 comprises a generally rectangular body formed from any suitable material, either metal, plastic, or ceramic.
  • the body has a relatively large diameter, centrally located cylindrical bore 152 which extends inwardly from the lower face substantially through the body but leaving a small flange portion 154'.
  • a slidable, cylindrical housing member 156 Positioned within the bore 152 is a slidable, cylindrical housing member 156 which is closely and slidably received within bore 152.
  • a key member prevents rotation of member 156
  • Member 156 is prevented from moving out the lower end of the bore by a retainer ring 158 threaded in the lower end of bore 152.
  • the body member 156 is normally maintained biased in engagement with retainer 158 by a relatively light compression spring 160 positioned between shoulder 162 and flange 154.
  • an internal bore 164 which constitutes the medicament and gas pressure chambers.
  • the lower end of bore 164 is provided with a small diameter outlet 166 which connects with the nozzle outlet orifice 168.
  • the nozzle member 170 is releasably threaded to the end of body 156 so that it can be changed as desired.
  • Piston 176 is formed from any suitable material so as to provide a proper seal between the two chamber portions while allowing relatively free movement of the piston vertically in the chamber.
  • adjustment of the medicament quantity is controlled by a threaded sleeve member 178 carried in the upper end of bore 164.
  • member 178 By rotation of member 178, its lower end 180 is shifted so as to vary the maximum vertical upward distance that the piston 176 can move. This, of course, varies the space or size of the medicament chamber 174.
  • Adjustment of the member 178 is indicated, for example, by suitable indicator marks formed on the body 150 and the upper surface of member 178.
  • means are provided for selectively moving the piston 176 to its upper position so that filling of the medicament chamber portion can take place.
  • These means comprise a vertically reciprocable shaft 182 having an enlarged lower end portion 184.
  • the shaft 182 is connected at its upper end with a push button or actuating knob 184 having an outwardly extending flange sealing surface 186.
  • the flange portion 186 engages under a machined flange or lip 188 formed internally of member 178. This seals the pressure chamber.
  • a biasing spring 190 acts against the under surface of push button 178 to maintain the shaft and push button normally biased to the solid line position. At is lower end, the
  • spring 190 engages a snap ring 192 positioned in an internal groove in member 178.
  • push button 184 is pushed downwardly driving the enlarged diameter end portion 184 into a correspondingly shaped opening 194 formed in piston 176. Thereafter, release of the push button allows the spring 190 to push the shaft and push button back to the solid line position shown. This pulls the piston 178 upwardly into engagement with the end face 180. Additionally, portion 184 retracts from opening 194 and the piston stays in its raised position merely by friction between the piston and the internal walls or bore 164. With the piston in the raised position, medicament can be supplied to the medicament chamber 174.
  • the medicament ampules and gas cartridges 198, 199 are carried in suitable bores formed inwardly from the right hand end of body 154.
  • a cover plate 204 is connected to the body with a screw 206. By removing screw 206, cover plate 204 can be removed and the used cartridges removed and new cartridges placed therein. Additionally, suitable needles for puncturing the ends of the sealed cartridges are carried on the inner ends of the bore in the manner shown in FIG. 8.
  • the medicament is supplied from medicament ampule 198 through the valve assembly 200 to line 202 which connects through passage 166 with medicament chamber 174.
  • the medicament ampule is under a slight internal pressure so that medicament is forcibly actuated into the chamber 174.
  • the medicament ampule is shown as having a different configuration than that used in the FIG. 1 embodiment, it should be appreciated that the same medicament ampules could be used, if desired.
  • the valve assembly 200 comprises a cylindrical valve member 210 closely received within a cylindrical bore 212 formed inwardly from the upper surface of body 150.
  • the valve member 210 is retained in the bore while being free to rotate by a retainer plate member 214 which is positioned in a groove 216 which extends across the top surface of body 150.
  • a flange 218 is formed about valve member 210 and is held beneath the plate 214.
  • Valve member 210 is provided with transversely extending passages which function to connect the gas and medicament supply passage with the chambers.
  • passage 218 is positioned so that when the valve member is rotated to the fill" position shown in FIG. 9, passage 218 connects from the needle 220 to the passage 202.
  • the upper transverse passage 222 is out of alignment with the gas supply needle 224 so that the apparatus cannot be inadvertently fired.
  • valve member 210 can be rotated back to the fire" position. Consequently, transverse passage 222 is aligned with needle 224 and passage 226. it is still not possible however, to supply high pressure gas to the gas chamber 172.
  • the connecting passage 228 is formed from the gas chamber 172 through the wall of member 156 as best shown in FIG. 8. Although passage 228 is in vertical alignment with passage 226, in the normal position of member 156 it is substantially therebelow. Accordingly, engagement of member 256 and the internal wall of bore 152 serves as a valve to prevent flow of gas into the gas pressure chamber. When it is desired to inject the medicament, it is only necessary to press the nozzle against the patients skin and move member 156 upwardly against the bias of spring 160. When passage 228 is aligned with passage 226, high pressure gas can flow into the chamber to product an injection.
  • a pressurized cleaning fluid ampule could be placed in the chamber for the medicament ampule 198 and the unit filled and fired.
  • the subject embodiment provides an arrangement whereby the passage 230 can be used to flush cleaning fluid through the medicament chamber 174 as well as through the medicament ampule and the needle 220.
  • a second needle 232 is connected into the medicament ampule 198.
  • a flow passage 234 connects from needle 232 to the bore 212.
  • Valve member 210 has a transversely extending passage 236 which, when the valve is rotated to the clean position, connects between lines 230 and 234.
  • a laterally extending cross passage 238 is, when the device is in the cleaning position, connected between lines 202 and needle 220. Consequently,
  • cleaning fluid can be flushed with a syringe through line 230 and needle 232 back through needle 220 to chamber 174.
  • the nozzles 28 can be color coded with the medicament and gas pressure ampules for various types of injections.
  • a higher gas pressure may be used together with a nozzle of a particular diameter. ln such instances, the proper nozzle can be made of the same color as the gas pressure cartridge.
  • a velocity type medicament injector comprising:
  • a first body portion including a medicament receiving chamber having at least one orifice through which medicament can be ejected, said chamber including at least one movable wall portion through which pressure can be applied to medicament in said chamber to cause it to be ejected through the orifice at a velocity sufficient to enter tissue without use of a needle;
  • a second body portion connected with said first body portion and including housing means carrying a plurality of fluid containers and at least one propellant gas cartridge;
  • passage means including valve means connected between the housing means and the first body portion to controllably supply fluid and pressurizing gas to the chamber on opposite sides of the movable wall;
  • indexing means for permitting movement of at least that portion of the housing means which carries said plurality of fluid containers relative to the first body portion to bring selected ones of said fluid containers into flow relationship with said passage means.
  • said movable wall comprises a piston slidable in said medicament chamber and dividing said medicament chamber into first and second chamber portions.
  • valve means is carried in said first body portion and comprises a rotatable valve member.
  • said movable wall means comprises a piston in said medicament chamber and wherein said passage means includes a first passage for supplying pressurized gas to one side of said piston and a second passage for supplying medicament to the opposite side of said piston.
  • said medicament chamber includes means for adjusting the amount of medicament which can be held in said chamber.
  • said housing means includes openings in which said containers are received, said openings including means for opening said containers.
  • said movable wall includes a piston slidable in said medicament chamber and including means for limiting the movement of said piston.
  • valve means comprises a single valve element controlling flow through between said first and said second passage portions.
  • a velocity type medicament injector including a first housing adapted to hold medicament and a propela second housing carried by said first housing and movable relative thereto, said second housing including a medicament chamber having a movable wall portion and an outlet orifice through which medicament can be ejected; passageway means for supplying medicament from said first housing to said medicament chamber, said passageway means further including a gas passageway extending through the second housing for supplying pressurized gas from said first housing to a position behind the movable wall portion; and,
  • the injector as defined in claim 17 including biasing means for continually biasing said second housing to a position wherein gas is prevented from flowing through said passageway.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US00093982A 1970-12-01 1970-12-01 Medicament injectors Expired - Lifetime US3714943A (en)

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BE (1) BE776084A (de)
BR (1) BR7107989D0 (de)
CH (1) CH536117A (de)
DE (1) DE2158910A1 (de)
FR (1) FR2117197A5 (de)
IL (1) IL38242A0 (de)
IT (2) IT945204B (de)
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Cited By (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3908651A (en) * 1974-05-17 1975-09-30 Daystrol Scient Inc Medicament injection device
US4196730A (en) * 1977-08-01 1980-04-08 Wilson Dennis R Liquid drug dispenser
US4564360A (en) * 1982-10-08 1986-01-14 Fisons Plc Adjustable dose injection pistol
WO1987003494A1 (en) * 1985-12-12 1987-06-18 Injet Medical Products, Inc Needleless hypodermic injection device
US4850967A (en) * 1986-06-17 1989-07-25 Sicim Spa Portable endermic injector
US4856567A (en) * 1986-08-04 1989-08-15 Sicim Spa Loader-mixer device for endermic injectors
WO1989008469A1 (en) * 1988-03-14 1989-09-21 James Stuart Parsons Disposable needleless injection system
US4902281A (en) * 1988-08-16 1990-02-20 Corus Medical Corporation Fibrinogen dispensing kit
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US5061247A (en) * 1988-12-09 1991-10-29 Terumo Kabushiki Kaisha Gasket and medical device using the same
US5312335A (en) * 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5411485A (en) * 1993-04-19 1995-05-02 Hyprotek Catheter access system and method
US5458275A (en) * 1994-07-11 1995-10-17 Liquid Control Corporation Positive-displacement dispensing device
US5571178A (en) * 1991-02-22 1996-11-05 Ledergerber; Walter J. Breast implant introducer
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5656035A (en) * 1995-04-25 1997-08-12 Avoy; Donald R. Refillable fibrinogen dispensing kit
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5723006A (en) * 1991-02-22 1998-03-03 Ledergerber; Walter J. Breast implant introducer
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5899879A (en) * 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
US6471669B2 (en) 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US20030088207A1 (en) * 1999-11-23 2003-05-08 Felton International, Inc. Jet injector with hand piece
US6607510B2 (en) 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US6645170B2 (en) 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
WO2003103752A1 (en) * 2002-06-04 2003-12-18 Bioject Inc. Needle-free injection system
US20040074076A1 (en) * 2002-10-16 2004-04-22 Bioject Inc. Drug cartridge assembly and method of manufacture
US6783509B1 (en) 1998-11-18 2004-08-31 Bioject Inc. Single-use needle-less hypodermic jet injection apparatus and method
US20040199106A1 (en) * 2002-06-04 2004-10-07 Sergio Landau Needle-free injection system
US20050066471A1 (en) * 2003-09-30 2005-03-31 Miller Paul R. Color-coded cleaning nozzles and method of cleaning
US20050267403A1 (en) * 2004-05-28 2005-12-01 Sergio Landau Needle-free injection system
US20070027428A1 (en) * 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US20070118094A1 (en) * 2005-05-03 2007-05-24 John Bingham Needle-less injector and method of fluid delivery
US20070191762A1 (en) * 2002-05-30 2007-08-16 Kerry Quinn Needleless injector and ampule system
US20080086079A1 (en) * 2006-10-06 2008-04-10 Bioject, Inc. Triggering mechanism for needle-free injector
US20080208114A1 (en) * 2007-02-23 2008-08-28 Sergio Landau Needle-free injection devices and drug delivery systems therefor
US20080281261A1 (en) * 2005-05-03 2008-11-13 Genesis Medical Technologies, Inc. Needle-less injector
WO2009065801A1 (de) * 2007-11-21 2009-05-28 Robert Bosch Gmbh Befüllvorrichtung mit kühlung und system zum verabreichen eines flüssigen medikaments
US20090270793A1 (en) * 2005-12-14 2009-10-29 Domash David M Priming a Microsurgical System
US20100179474A1 (en) * 2007-06-09 2010-07-15 Ivonne Silvester Device for Storing and Administering Active Substances
WO2010065126A3 (en) * 2008-12-05 2010-08-19 Ams Research Corporation Devices, systems and methods for delivering fluid to tissue
US20110238006A1 (en) * 2008-12-16 2011-09-29 Crank Justin M Needleless injection device components, systems, and methods
EP2815778A1 (de) * 2013-06-21 2014-12-24 F. Hoffmann-La Roche AG Tragbares Infusionsgerät für Kinder mit wiederbefüllbarer Dosiereinheit kleinen Volumeninhalts
US20150238695A1 (en) * 2004-11-22 2015-08-27 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
US9433735B2 (en) 2011-12-13 2016-09-06 Pharmajet Inc. Needle-free intradermal injection device
US20220218907A1 (en) * 2021-01-10 2022-07-14 Orlance, Inc. Medical Delivery Device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008508A1 (en) * 1990-11-09 1992-05-29 Sy-Quest International Limited Needleless hypodermic jet injector device

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US2754818A (en) * 1950-06-24 1956-07-17 Scherer Corp R P Hypo jet injector
US2645223A (en) * 1951-02-17 1953-07-14 Becton Dickinson Co Injection device
US3057349A (en) * 1959-12-14 1962-10-09 Ismach Aaron Multi-dose jet injection device
US3330277A (en) * 1964-08-17 1967-07-11 Scherer Corp R P Multidose hypodermic injector
US3461867A (en) * 1966-03-14 1969-08-19 Mizzy Inc Needleless injector
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Cited By (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3908651A (en) * 1974-05-17 1975-09-30 Daystrol Scient Inc Medicament injection device
US4196730A (en) * 1977-08-01 1980-04-08 Wilson Dennis R Liquid drug dispenser
US4564360A (en) * 1982-10-08 1986-01-14 Fisons Plc Adjustable dose injection pistol
WO1987003494A1 (en) * 1985-12-12 1987-06-18 Injet Medical Products, Inc Needleless hypodermic injection device
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
US4850967A (en) * 1986-06-17 1989-07-25 Sicim Spa Portable endermic injector
US4856567A (en) * 1986-08-04 1989-08-15 Sicim Spa Loader-mixer device for endermic injectors
WO1989008469A1 (en) * 1988-03-14 1989-09-21 James Stuart Parsons Disposable needleless injection system
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
US4902281A (en) * 1988-08-16 1990-02-20 Corus Medical Corporation Fibrinogen dispensing kit
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US5061247A (en) * 1988-12-09 1991-10-29 Terumo Kabushiki Kaisha Gasket and medical device using the same
US5503627A (en) * 1989-11-09 1996-04-02 Bioject, Inc. Ampule for needleless injection
US5312335A (en) * 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5571178A (en) * 1991-02-22 1996-11-05 Ledergerber; Walter J. Breast implant introducer
US5723006A (en) * 1991-02-22 1998-03-03 Ledergerber; Walter J. Breast implant introducer
US5411485A (en) * 1993-04-19 1995-05-02 Hyprotek Catheter access system and method
US5458275A (en) * 1994-07-11 1995-10-17 Liquid Control Corporation Positive-displacement dispensing device
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5891085A (en) * 1995-01-09 1999-04-06 Medi-Ject Corporation Nozzle assembly with lost motion connection for medical injector assembly
US5919159A (en) * 1995-01-09 1999-07-06 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5846233A (en) * 1995-01-09 1998-12-08 Medi-Ject Corporation Coupling device for medical injection system
US5656035A (en) * 1995-04-25 1997-08-12 Avoy; Donald R. Refillable fibrinogen dispensing kit
US6083197A (en) * 1995-12-19 2000-07-04 Umbaugh; Jerald C. Spring-actuated needleless injector
US5899879A (en) * 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US6783509B1 (en) 1998-11-18 2004-08-31 Bioject Inc. Single-use needle-less hypodermic jet injection apparatus and method
US7029457B2 (en) * 1999-11-23 2006-04-18 Felton International, Inc. Jet injector with hand piece
US20030088207A1 (en) * 1999-11-23 2003-05-08 Felton International, Inc. Jet injector with hand piece
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
US6471669B2 (en) 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US6641554B2 (en) * 2001-03-05 2003-11-04 Bioject Medical Technologies, Inc. Disposable needle-free injection apparatus and method
US6645170B2 (en) 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
US6607510B2 (en) 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US20070191762A1 (en) * 2002-05-30 2007-08-16 Kerry Quinn Needleless injector and ampule system
US6676630B2 (en) 2002-06-04 2004-01-13 Bioject Medical Technologies, Inc. Needle-free injection system
US20040199106A1 (en) * 2002-06-04 2004-10-07 Sergio Landau Needle-free injection system
US7238167B2 (en) 2002-06-04 2007-07-03 Bioject Inc. Needle-free injection system
WO2003103752A1 (en) * 2002-06-04 2003-12-18 Bioject Inc. Needle-free injection system
US6883222B2 (en) 2002-10-16 2005-04-26 Bioject Inc. Drug cartridge assembly and method of manufacture
US20040074076A1 (en) * 2002-10-16 2004-04-22 Bioject Inc. Drug cartridge assembly and method of manufacture
US20050066471A1 (en) * 2003-09-30 2005-03-31 Miller Paul R. Color-coded cleaning nozzles and method of cleaning
US20100069831A1 (en) * 2004-05-28 2010-03-18 Bioject Inc. Needle-free injection system
US7854720B2 (en) 2004-05-28 2010-12-21 Bioject, Inc. Needle-free injection system
US20050267403A1 (en) * 2004-05-28 2005-12-01 Sergio Landau Needle-free injection system
US7717874B2 (en) 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
US20150238695A1 (en) * 2004-11-22 2015-08-27 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9352091B2 (en) * 2004-11-22 2016-05-31 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8529500B2 (en) 2005-05-03 2013-09-10 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US9333300B2 (en) 2005-05-03 2016-05-10 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US7618393B2 (en) 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US20080281261A1 (en) * 2005-05-03 2008-11-13 Genesis Medical Technologies, Inc. Needle-less injector
US7699802B2 (en) 2005-05-03 2010-04-20 Pharmajet, Inc. Needle-less injector
US20070118094A1 (en) * 2005-05-03 2007-05-24 John Bingham Needle-less injector and method of fluid delivery
US20070027428A1 (en) * 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US10099011B2 (en) 2005-05-03 2018-10-16 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US20090270793A1 (en) * 2005-12-14 2009-10-29 Domash David M Priming a Microsurgical System
US20080086079A1 (en) * 2006-10-06 2008-04-10 Bioject, Inc. Triggering mechanism for needle-free injector
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
US8105272B2 (en) 2006-10-06 2012-01-31 Bioject, Inc. Triggering mechanism for a needle-free injector
US11878147B2 (en) 2006-11-13 2024-01-23 Pharmajet Inc. Needle-less injector and method of fluid delivery
US7744563B2 (en) 2007-02-23 2010-06-29 Bioject, Inc. Needle-free injection devices and drug delivery systems therefor
US20080208114A1 (en) * 2007-02-23 2008-08-28 Sergio Landau Needle-free injection devices and drug delivery systems therefor
US8105291B2 (en) * 2007-06-09 2012-01-31 Ivonne Silvester Device for storing and administering active substances
US20100179474A1 (en) * 2007-06-09 2010-07-15 Ivonne Silvester Device for Storing and Administering Active Substances
US8839828B2 (en) 2007-11-21 2014-09-23 Robert Bosch Gmbh Filling device having cooling and system for administering a liquid medication
WO2009065801A1 (de) * 2007-11-21 2009-05-28 Robert Bosch Gmbh Befüllvorrichtung mit kühlung und system zum verabreichen eines flüssigen medikaments
US20110023997A1 (en) * 2007-11-21 2011-02-03 Dick Scholten Filling device having cooling and system for administering a liquid medication
WO2010065126A3 (en) * 2008-12-05 2010-08-19 Ams Research Corporation Devices, systems and methods for delivering fluid to tissue
US8876759B2 (en) * 2008-12-05 2014-11-04 Ams Research Corporation Devices, systems and methods for delivering fluid to tissue
US20110245762A1 (en) * 2008-12-05 2011-10-06 Crank Justin M Devices, systems and methods for delivering fluid to tissue
US9579462B2 (en) 2008-12-16 2017-02-28 Astora Women's Health Holdings, Llc Needleless injection device components, systems, and methods
US20110238006A1 (en) * 2008-12-16 2011-09-29 Crank Justin M Needleless injection device components, systems, and methods
US8852142B2 (en) * 2008-12-16 2014-10-07 Ams Research Corporation Needleless injection device components, systems, and methods
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
US10463795B2 (en) 2011-08-02 2019-11-05 Pharmajet Inc. Needle-free injection methods
US11471603B2 (en) 2011-08-02 2022-10-18 Pharmajet, Inc. Needle-free injector
US9433735B2 (en) 2011-12-13 2016-09-06 Pharmajet Inc. Needle-free intradermal injection device
US9700675B2 (en) 2011-12-13 2017-07-11 Pharmajet Inc. Needle-free intradermal injection device
US10322238B2 (en) 2011-12-13 2019-06-18 Pharmajet, Inc. Needle-free intradermal injection device
US11154659B2 (en) 2011-12-13 2021-10-26 Pharmajet Inc. Needle-free intradermal injection device
EP2815778A1 (de) * 2013-06-21 2014-12-24 F. Hoffmann-La Roche AG Tragbares Infusionsgerät für Kinder mit wiederbefüllbarer Dosiereinheit kleinen Volumeninhalts
US20220218907A1 (en) * 2021-01-10 2022-07-14 Orlance, Inc. Medical Delivery Device
WO2022150627A1 (en) * 2021-01-10 2022-07-14 Orlance, Inc. Medical delivery device

Also Published As

Publication number Publication date
CH536117A (de) 1973-04-30
FR2117197A5 (de) 1972-07-21
IT945204B (it) 1973-05-10
IT945203B (it) 1973-05-10
SE7115325L (de) 1972-06-02
BR7107989D0 (pt) 1973-05-31
NL7116313A (de) 1972-06-05
BE776084A (fr) 1972-03-16
DE2158910A1 (de) 1972-06-29
IL38242A0 (en) 1972-01-27
AU3636071A (en) 1973-06-07

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