US3688763A - Diagnostic device and method - Google Patents
Diagnostic device and method Download PDFInfo
- Publication number
- US3688763A US3688763A US54945A US3688763DA US3688763A US 3688763 A US3688763 A US 3688763A US 54945 A US54945 A US 54945A US 3688763D A US3688763D A US 3688763DA US 3688763 A US3688763 A US 3688763A
- Authority
- US
- United States
- Prior art keywords
- sponge
- casing
- patient
- large intestine
- recovering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
Definitions
- Tl'1 patient swallows the sponge contained compressed in a gelatin casing with [56] References Ciud an enteric coating, the casing being dissolved in the large intestine to release the sponge, which is naturally UNITED STATES PATENTS evacuated by the patient and recovered for analysis.
- This invention relates to a diagnostic method for the detection of diseases and to a diagnostic device. More particularly, it relates to a method of and device for obtaining cellular material from the large intestine of a patient, for subsequent cytological examination.
- a further object is to provide a simple such method which can be conducted by the patient himself, and involves the use of an inexpensive device only.
- a method of collecting cellular material from the large intestine of a patient which comprises administering orally to the patient a capsule comprising a readily compressible sponge of fine pore structure enclosed in a gelatin or similar enzymedegradable casing, the casing having an enteric coating over its outer surface, recoveringthe sponge after its natural evacuation from the body, and recovering from the sponge cells collected thereon during its passage through the large intestine of the body.
- a diagnostic device of an overall size such as to allow it to be swallowed by a patient and passed through the intestines of the body, said device comprising a sponge retained in compressed form inside a capsule, the capsule being insoluble in gastric juices of the stomach, but soluble to release the sponge in the large intestine.
- the type of sponge is chosen with a view to easy compressibility, and very small adherence in relation to the walls of the intestines of the body. It must also, of course, be inert to the action of fluids present in the intestines, to which it will be exposed during use. Finely porous polyurethane sponge is suitable.
- the capsule In use, the capsule is swallowed by the patient, and passes into the stomach. Due to the presence of the enteric coating, the capsule remains unchanged and unaffected in the stomach, and passes into the small intestine. The secretions present in the small intestine start to attack the enteric coating and dissolve it. The gelatin shells are then attached by these secretions. Thus the capsule is disintegrated and the sponge released in the small intestine. The sponge is propelled along the intestines by the normal peristaltic action of the intestines, and eventually enters the large intestine. Here, the re-expanded sponge absorbs mucous, containing cells from the large intestine. The sponge travels on as before and is eventually naturally expelled from the anus, where it is carefully collected and the cells it has picked up removed and analyzed.
- a method of collecting cellular material from the large intestine of a patient which comprises fasting the patient, administering orally to the patient a capsule comprising an enzyme degradable casing, an enteric coating over the outer surface of said casing, and a readily compressible sponge of fine pore structure enclosed within said casing, recovering the sponge material after its natural evacuation from the body, and recovering from the sponge cells collected thereon during its passage through the large intestine of the body.
- a diagnostic device of an overall size such as to allow it to be swallowed by a patient and passed through the intestines of the body, said device being generally cylindrical in overall shape and comprising an enzyme degradable gelatine casing, a cellulose acetate phthalate based enteric coating over the outer surface of said casing, and a readily compressible and re-expandable finely porous polyurethane sponge retained and enclosed within said casing in a compressed form.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3784169 | 1969-07-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3688763A true US3688763A (en) | 1972-09-05 |
Family
ID=10399382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US54945A Expired - Lifetime US3688763A (en) | 1969-07-28 | 1970-07-15 | Diagnostic device and method |
Country Status (2)
Country | Link |
---|---|
US (1) | US3688763A (da) |
GB (1) | GB1302548A (da) |
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3877464A (en) * | 1972-06-07 | 1975-04-15 | Andrew R Vermes | Intra-uterine biopsy apparatus |
US3998211A (en) * | 1974-08-23 | 1976-12-21 | Louis Bucalo | Structures for growing cultures within human and animal bodies |
FR2374048A1 (fr) * | 1976-12-20 | 1978-07-13 | Bucalo Louis | Procede et dispositif pour recueillir des fluides d'un corps vivant, notamment humain |
US4172446A (en) * | 1974-12-20 | 1979-10-30 | Louis Bucalo | Apparatus for collecting body fluids |
US4186730A (en) * | 1974-08-23 | 1980-02-05 | Louis Bucalo | Methods for collecting body fluids |
US4257427A (en) * | 1973-02-05 | 1981-03-24 | Louis Bucalo | Method for collecting body fluids |
US4735214A (en) * | 1986-09-05 | 1988-04-05 | Berman Irwin R | Gastrointestinal diagnostic capsule and method of use |
US4774962A (en) * | 1985-09-23 | 1988-10-04 | Walter Sarstedt Kunststoff-Spritzgusswerk | Method of extracting human saliva |
WO1989000403A1 (en) * | 1987-07-13 | 1989-01-26 | Huhtamäki Oy | Device and method for the determination of incisional wound healing ability |
US4817632A (en) * | 1987-06-23 | 1989-04-04 | Bioquant, Inc. | Oral fluid collection article |
US4979947A (en) * | 1985-10-10 | 1990-12-25 | Berman Irwin R | Encapsulated expandible continence device |
AU618016B2 (en) * | 1987-07-13 | 1991-12-12 | Huhtamaki Oy | Device and method for the determination of incisional wound healing ability |
EP0542299A2 (en) * | 1991-11-15 | 1993-05-19 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Ester linkage containing polymers for use in pharmaceutical preparations |
US5231992A (en) * | 1990-06-04 | 1993-08-03 | Leon Arnaldo C | Low-impact cervical cell and fluid collector |
US5603950A (en) * | 1990-08-14 | 1997-02-18 | Ratjen; Werner | Agent for oral intake |
US5971942A (en) * | 1996-12-03 | 1999-10-26 | Gu; Howard H. | Intestinal fluid sampler |
WO2001017510A1 (de) * | 1999-09-06 | 2001-03-15 | Beisel Guenther | Mittel zur stimulanz der darmtätigkeit sowie verfahren zu dessen herstellung |
WO2001017509A1 (de) * | 1999-09-06 | 2001-03-15 | Beisel Guenther | Mittel zur verbesserung und erhaltung der darmtätigkeit sowie verfahren zu dessen herstellung |
WO2002015887A1 (en) * | 2000-08-17 | 2002-02-28 | Machines Industrielles Etablissements | Consumable container |
US20030072804A1 (en) * | 2001-03-19 | 2003-04-17 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
US20030091610A1 (en) * | 2001-03-19 | 2003-05-15 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
US20100291266A1 (en) * | 2009-05-15 | 2010-11-18 | Tibor Czinki | Natural Sponge Food and Regimen |
US8491495B1 (en) * | 2012-11-16 | 2013-07-23 | L. Zane Shuck | Human intestinal tract research and diagnostic system to evaluate patients and advance medical science and bioengineering and to determine processes in the gut and causes of diseases |
US20140163416A1 (en) * | 2012-11-16 | 2014-06-12 | L. Zane Shuck | In Vivo Device and Method for Researching GI Tract Processes, Microbes, and Variables Associated with Illnesses and Diseases |
US20140162305A1 (en) * | 2012-11-30 | 2014-06-12 | L. Zane Shuck | Patient In Vivo Gut Diagnostic and Treatment Tool |
US20150112166A1 (en) * | 2012-11-16 | 2015-04-23 | L. Zane Shuck | In Vivo Technology System for Human Gut Research, Diagnostics and Treatment |
US20160081677A1 (en) * | 2014-09-18 | 2016-03-24 | Covidien Lp | Regions of varying physical properties in a compressible cell collection device |
FR3072556A1 (fr) * | 2017-10-25 | 2019-04-26 | Universite Grenoble Alpes | Dispositif de prelevement de fluide intestinal |
US10751033B2 (en) | 2014-09-18 | 2020-08-25 | Covidien Lp | Use of expansion-force elements in a compressible cell collection device |
US10792020B2 (en) | 2014-09-18 | 2020-10-06 | Covidien Lp | Tapered geometry in a compressible cell collection device |
US11786474B2 (en) | 2004-02-10 | 2023-10-17 | Biolumen Inc. | Device and method for reducing calorie intake |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1979000811A1 (en) * | 1978-03-22 | 1979-10-18 | J Pawelec | Device for study of the alimentary canal |
CN109010302A (zh) * | 2017-06-12 | 2018-12-18 | 赣州卡迪瑞贸易有限公司 | 海绵胶囊 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US24666A (en) * | 1859-07-05 | Improvement in revolving fire-arms | ||
US298720A (en) * | 1884-05-20 | Capsule | ||
US471343A (en) * | 1892-03-22 | Alexander poehl | ||
US1438064A (en) * | 1921-11-16 | 1922-12-05 | Johnson & Johnson | Dental pellet |
US1575123A (en) * | 1922-08-01 | 1926-03-02 | Martocci-Pisculli Leon | Medical appliance |
US2798024A (en) * | 1954-06-02 | 1957-07-02 | Lilly Co Eli | Composite enteric tablet of erythromycin and sulfonamides |
US3081233A (en) * | 1960-08-08 | 1963-03-12 | Upjohn Co | Enteric-coated pilules |
US3118439A (en) * | 1957-04-09 | 1964-01-21 | Perrenoud Jean-Pierre | Diagnostic and medicating capsule and the method of use |
US3315660A (en) * | 1963-08-08 | 1967-04-25 | Carlos A Abella | Capsule for insertion in the digestive track |
-
1969
- 1969-07-28 GB GB3784169A patent/GB1302548A/en not_active Expired
-
1970
- 1970-07-15 US US54945A patent/US3688763A/en not_active Expired - Lifetime
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US24666A (en) * | 1859-07-05 | Improvement in revolving fire-arms | ||
US298720A (en) * | 1884-05-20 | Capsule | ||
US471343A (en) * | 1892-03-22 | Alexander poehl | ||
US1438064A (en) * | 1921-11-16 | 1922-12-05 | Johnson & Johnson | Dental pellet |
US1575123A (en) * | 1922-08-01 | 1926-03-02 | Martocci-Pisculli Leon | Medical appliance |
US2798024A (en) * | 1954-06-02 | 1957-07-02 | Lilly Co Eli | Composite enteric tablet of erythromycin and sulfonamides |
US3118439A (en) * | 1957-04-09 | 1964-01-21 | Perrenoud Jean-Pierre | Diagnostic and medicating capsule and the method of use |
US3081233A (en) * | 1960-08-08 | 1963-03-12 | Upjohn Co | Enteric-coated pilules |
US3315660A (en) * | 1963-08-08 | 1967-04-25 | Carlos A Abella | Capsule for insertion in the digestive track |
Cited By (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3877464A (en) * | 1972-06-07 | 1975-04-15 | Andrew R Vermes | Intra-uterine biopsy apparatus |
US4257427A (en) * | 1973-02-05 | 1981-03-24 | Louis Bucalo | Method for collecting body fluids |
US3998211A (en) * | 1974-08-23 | 1976-12-21 | Louis Bucalo | Structures for growing cultures within human and animal bodies |
US4186730A (en) * | 1974-08-23 | 1980-02-05 | Louis Bucalo | Methods for collecting body fluids |
US4172446A (en) * | 1974-12-20 | 1979-10-30 | Louis Bucalo | Apparatus for collecting body fluids |
FR2374048A1 (fr) * | 1976-12-20 | 1978-07-13 | Bucalo Louis | Procede et dispositif pour recueillir des fluides d'un corps vivant, notamment humain |
US4774962A (en) * | 1985-09-23 | 1988-10-04 | Walter Sarstedt Kunststoff-Spritzgusswerk | Method of extracting human saliva |
US4979947A (en) * | 1985-10-10 | 1990-12-25 | Berman Irwin R | Encapsulated expandible continence device |
US4735214A (en) * | 1986-09-05 | 1988-04-05 | Berman Irwin R | Gastrointestinal diagnostic capsule and method of use |
US4817632A (en) * | 1987-06-23 | 1989-04-04 | Bioquant, Inc. | Oral fluid collection article |
WO1989000403A1 (en) * | 1987-07-13 | 1989-01-26 | Huhtamäki Oy | Device and method for the determination of incisional wound healing ability |
AU618016B2 (en) * | 1987-07-13 | 1991-12-12 | Huhtamaki Oy | Device and method for the determination of incisional wound healing ability |
US5113871A (en) * | 1987-07-13 | 1992-05-19 | Jouko Viljanto | Device for the determination of incisional wound healing ability |
US5231992A (en) * | 1990-06-04 | 1993-08-03 | Leon Arnaldo C | Low-impact cervical cell and fluid collector |
US5603950A (en) * | 1990-08-14 | 1997-02-18 | Ratjen; Werner | Agent for oral intake |
EP0542299A2 (en) * | 1991-11-15 | 1993-05-19 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Ester linkage containing polymers for use in pharmaceutical preparations |
EP0542299A3 (en) * | 1991-11-15 | 1993-06-02 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Ester linkage containing polymers for use in pharmaceutical preparations |
US5576020A (en) * | 1991-11-15 | 1996-11-19 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adjuvant for pharmaceutical preparations |
US5644012A (en) * | 1991-11-15 | 1997-07-01 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adjuvant for pharmaceutical preparations |
US5854368A (en) * | 1991-11-15 | 1998-12-29 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adjuvant for pharmaceutical preparations |
US5971942A (en) * | 1996-12-03 | 1999-10-26 | Gu; Howard H. | Intestinal fluid sampler |
WO2001017510A1 (de) * | 1999-09-06 | 2001-03-15 | Beisel Guenther | Mittel zur stimulanz der darmtätigkeit sowie verfahren zu dessen herstellung |
WO2001017509A1 (de) * | 1999-09-06 | 2001-03-15 | Beisel Guenther | Mittel zur verbesserung und erhaltung der darmtätigkeit sowie verfahren zu dessen herstellung |
WO2002015887A1 (en) * | 2000-08-17 | 2002-02-28 | Machines Industrielles Etablissements | Consumable container |
US20040022972A1 (en) * | 2000-08-17 | 2004-02-05 | Machines Industrielles Etablissements | Consumable container |
US20030072804A1 (en) * | 2001-03-19 | 2003-04-17 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
US20030091610A1 (en) * | 2001-03-19 | 2003-05-15 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
US11786474B2 (en) | 2004-02-10 | 2023-10-17 | Biolumen Inc. | Device and method for reducing calorie intake |
US20100291266A1 (en) * | 2009-05-15 | 2010-11-18 | Tibor Czinki | Natural Sponge Food and Regimen |
US8915863B2 (en) * | 2012-11-16 | 2014-12-23 | L. Zane Shuck | In vivo device and method for researching GI tract processes, microbes, and variables associated with illnesses and diseases |
US20140163416A1 (en) * | 2012-11-16 | 2014-06-12 | L. Zane Shuck | In Vivo Device and Method for Researching GI Tract Processes, Microbes, and Variables Associated with Illnesses and Diseases |
US20150112166A1 (en) * | 2012-11-16 | 2015-04-23 | L. Zane Shuck | In Vivo Technology System for Human Gut Research, Diagnostics and Treatment |
US9215997B2 (en) * | 2012-11-16 | 2015-12-22 | L. Zane Shuck | In vivo technology system for human gut research, diagnostics and treatment |
US8491495B1 (en) * | 2012-11-16 | 2013-07-23 | L. Zane Shuck | Human intestinal tract research and diagnostic system to evaluate patients and advance medical science and bioengineering and to determine processes in the gut and causes of diseases |
US20140162305A1 (en) * | 2012-11-30 | 2014-06-12 | L. Zane Shuck | Patient In Vivo Gut Diagnostic and Treatment Tool |
US8926526B2 (en) * | 2012-11-30 | 2015-01-06 | L. Zane Shuck | Patient in vivo gut diagnostic and treatment tool |
US20160081677A1 (en) * | 2014-09-18 | 2016-03-24 | Covidien Lp | Regions of varying physical properties in a compressible cell collection device |
US10751033B2 (en) | 2014-09-18 | 2020-08-25 | Covidien Lp | Use of expansion-force elements in a compressible cell collection device |
US10792020B2 (en) | 2014-09-18 | 2020-10-06 | Covidien Lp | Tapered geometry in a compressible cell collection device |
US11096677B2 (en) * | 2014-09-18 | 2021-08-24 | Covidien Lp | Regions of varying physical properties in a compressible cell collection device |
FR3072556A1 (fr) * | 2017-10-25 | 2019-04-26 | Universite Grenoble Alpes | Dispositif de prelevement de fluide intestinal |
WO2019081539A1 (fr) * | 2017-10-25 | 2019-05-02 | Universite Grenoble Alpes | Dispositif de prélèvement de fluide intestinal |
Also Published As
Publication number | Publication date |
---|---|
GB1302548A (da) | 1973-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3688763A (en) | Diagnostic device and method | |
Hardcastle et al. | The action of sennosides and related compounds on human colon and rectum | |
Harris | A Case of Diabetes Mellitus Quickly Following Mumps: On the Pathological Alterations of the Salivary Glands, Closely Resembling Those Found in the Pancreas, in a Case of Diabetes Mellitus | |
ES2227560T3 (es) | Preparacion diagnostipyloria la deteccion de helicobacter pilori. | |
Walker | Spontaneous closure of traumatic ventricular septal defect | |
Deyhle et al. | Endoscopy of the whole small intestine: preliminary communication | |
Salmon et al. | Clinical evaluation of fibre-optic sigmoidoscopy employing the Olympus CF-SB colonoscope | |
Rosof et al. | Metastasis from hypernephroma twenty years after nephrectomy: report of a case | |
Riedler et al. | Endoscopic decompression in “toxic megalcolon” | |
Brigden et al. | Extragenital granuloma inguinale in North Queensland | |
Knutson et al. | Value of colonoscopy in patients with rectal blood loss unexplained by rigid proctosigmoidoscopy and barium contrast enema examinations | |
Saleh Al-Hajjaj | Ectopic intratracheal thyroid presenting as bronchial asthma | |
Vlad et al. | Children would taste anything: foreign body ingestion-a multidisciplinary perspective and clinical practice algorithm. | |
Dixon et al. | Haemangioma of the mediastinum | |
Ramse | Stenosis of the Larynx in Infancy Haemangioma of the Larynx | |
JP2768559B2 (ja) | ヘリコバクテル・ピロリ(Helicobacter Pylori)の検出のための診断用調剤 | |
McLaren et al. | Preliminary observations on veripaque, a colonic actuator for use with barium enemata | |
Claude et al. | Thin-walled cavitary bronchiolar carcinoma | |
Spitzer et al. | Radiopaque suppositories | |
Jena et al. | BILE criteria: Is it too early, or a stage is set? | |
Jain et al. | Reactivation of a tuberculous lesion following bronchography | |
Faegenburg et al. | Intestinal obstruction caused by ingestion of a Heidelberg capsule: report of a case. | |
Huang et al. | Gastric mucormycosis presenting as diffuse thickening of the gastric wall with enhancement | |
Tytgat et al. | Colonoscopy in inflammatory bowel disease | |
Monto et al. | Comparative duodenal motility in patients with and without duodenal ulcer disease. |