US3645090A - Day-date quick-adjuster for calender timepiece - Google Patents
Day-date quick-adjuster for calender timepiece Download PDFInfo
- Publication number
- US3645090A US3645090A US47701A US3645090DA US3645090A US 3645090 A US3645090 A US 3645090A US 47701 A US47701 A US 47701A US 3645090D A US3645090D A US 3645090DA US 3645090 A US3645090 A US 3645090A
- Authority
- US
- United States
- Prior art keywords
- gear
- calendar
- stem
- day
- date
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- G—PHYSICS
- G04—HOROLOGY
- G04B—MECHANICALLY-DRIVEN CLOCKS OR WATCHES; MECHANICAL PARTS OF CLOCKS OR WATCHES IN GENERAL; TIME PIECES USING THE POSITION OF THE SUN, MOON OR STARS
- G04B19/00—Indicating the time by visual means
- G04B19/24—Clocks or watches with date or week-day indicators, i.e. calendar clocks or watches; Clockwork calendars
- G04B19/243—Clocks or watches with date or week-day indicators, i.e. calendar clocks or watches; Clockwork calendars characterised by the shape of the date indicator
- G04B19/247—Clocks or watches with date or week-day indicators, i.e. calendar clocks or watches; Clockwork calendars characterised by the shape of the date indicator disc-shaped
- G04B19/25—Devices for setting the date indicators manually
-
- G—PHYSICS
- G04—HOROLOGY
- G04B—MECHANICALLY-DRIVEN CLOCKS OR WATCHES; MECHANICAL PARTS OF CLOCKS OR WATCHES IN GENERAL; TIME PIECES USING THE POSITION OF THE SUN, MOON OR STARS
- G04B11/00—Click devices; Stop clicks; Clutches
- G04B11/006—Clutch mechanism between two rotating members with transfer of movement in only one direction (free running devices)
Definitions
- the correction torque transmitting arrangement is so designed that by turning said stem in one direction both calendar dials are rotated for correction in unison with each other and by turning the stem in the opposite direction only one of the dials is rotated independently from the other and in the same direction as before when the stem was rotated in said one direction.
- The'present invention relates broadly with improvement in and relating to calendar timepieces. More specifically, it relates to a quick-calendar correction mechanism for use with the timepiece of the above kind having a date calendar dial and a, day calendar dial operable independently from each other.
- One of recently advanced day and date calendar correction mechanisms is constructed so that by turning the conventional winding stem in one direction upon preparatory positioning thereof in its quick calendar correcting position, either of the both calendar displays is subjected correction and by turning the stern in the reverse direction the remaining calendar display is corrected.
- the winding stern must be rotated for performing one kind of calendar correction at first in one direction and then in the opposite direction for performing the remaining kind of calendar correction. Therefore, with use of the prior advanced correction mechanism, two successive operations must be adopted for carrying out the day and date calendar corrections.
- a still further object of the invention is to provide a calendar correction mechanism of the above kind, capable of providing the ability to correct the day calendar display in the reverse direction for attaining an easier and quicker day correction at the end ofa small month.
- F I0, I is a schematic plan view of a preferred first embodiment of the invention.
- FIG. 2 is a sectional view taken substantially along a section line A,-A' shown in FIG. 1.
- F IG; 3 is a sectional view taken substantially along a section line 8-8 shown in FIG. 1.
- FIGS. 4 and 5 are plan views of several main working parts of preferred second and third embodiments of the invention, respectively.
- FIG.v 6 is a sectional view taken substantially along a section line C-C' shown in FIG. 5.
- FIG. 7 is a schematic plan view of a fourth embodiment of the invention.
- F IG. 8 is a sectional view taken substantially along a section line D D' in FIG. 7.
- FIGS. 9 and 10 are schematic plan views of two different working modes of a preferred embodiment of the invention.
- F IO. 11 is a similar view to FIG. 9, illustrative of the time setting position of the fifth embodiment. 7
- FIGS. 12 and 13 are plan views of a sixth embodiment of the invention, illustrative of different operating positions of the mechanism.
- the numeral 10 represents a conventional plate of a timepiece movement and a conventional winding stem 11 is rotatably and slidably mounted in the plate.v
- the stem 11 is formed with a ring groove Ila with which a projection 12a of a setting lever 12 is kept in engagement as conventionally for the prevention of otherwise possible slip-out of the stem from position.
- Winding stem 11 carries a winding pinion l3 and a clutch wheel 14 having a gear portion 140 made integral therewith, as conventionally.
- Winding position 13 is slidable in the axial direction of the stem II and rotatable relative thereto, while clutch wheel 14 is arranged only slidable longitudinally of the stem, thus being rotatable in unison with the latter.
- Clutch wheel 14 is formed on its cylindrical peripheral surface with a ring groove 14b with which one end of clutch lever 15 is engaged, the latter lever being movable in unison with the push-in and drawout manual operation applied to the winding stem 11 by receiving motion therefrom through the setting lever 12.
- clutch wheel 14 having a tooth portion 14c being kept in its disengaged position with the tooth portion at 13a formed on the winding pinion I3.
- setting wheel 16 mounted rotatably on a stationary shaft portion 10a formed on the plate 10 is kept again in its disengaged position, as shown, with the toothed portion at of clutch wheel 14.
- the clutch wheel 14 is so positioned, as shown, in a stabilized way that its toothed portion 14a is positively kept in engagement with a gear which is rigid with a shaft 19 rotatably mounted in a lever 17.
- setting lever 12 is rotatably mounted around a shaft 20 which is rigid with the plate 10
- clutch lever 15 is rotatably mounted on its shaft 21 which is also rigid with the plate.
- a conventional clutch lever spring 22 urges the clutch lever 15 so as to establish a pressure contact thereof with setting lever 12.
- Numeral 23 represents a conventional setting lever spring the main nonelastic part of which is fixed onto the plate 10 by means of setting screws 23a and 23b.
- Setting lever spring 23 comprises an elastic arm 23c which is kept .in pressure. contact with setting lever pin 12b.
- Setting lever spring 23 is formed with an elastic arm 23d whichexerts a resilient pressure upon the setting lever 12 for keeping the latter in position within the timepiece movement.
- Setting wheel 16 is kept in meshing with minute wheel 24.
- the lever 17 is rotatably mounted on a shaft 25 which is rigid with the plate 10, said lever 17 being abutting under pressure against the setting lever pin 12b under the influence of a bar spring 26 which is shown only partially for simplicity of the drawing. Although not shown, this bar spring 26 is mounted at its root portion fixedly on the plate 10.
- lever 17 Since the lever 17 is kept in a positive pressure engagement with the setting lever 12b and movable in the counter clockwise direction in FIG. 1 irrespective of occasional and selective moving direction of the lever 12 caused by a push-in or drawout operation applied to the winding stem, indeed, by the intimate and positive cooperating engagement of cam parts 17a; 17b of the setting lever pin 17b.
- a gear 28 is rotatably mounted around a shaft 27 which is rigid with the lever, said gear 28 meshing with said gear 18.
- gear 29 On the same lever 17, there is a further gear 29 which is rotatable around a shaft rigid with the said lever.
- a further lever 30 is also mounted rotatable on the same shaft 25, a further shaft 31 being fixedly mounted on the said lever 30 and a further gear 32 being rotatably mounted on the shaft 31 and meshing with gear 29'.
- gear 29 rotates in clockwise direction in FIG. 1
- lever 30 is subjected to a .mechanical urging force acting in clockwise direction and gear 32 is brought into meshing with gear 34 which is rotatably mounted on the shaft at 33.
- gear 34 meshes at its ratchet tooth portion 34a with that shown at 35a of gear 35 which is rotatably mounted on the shaft 33.
- These ratchet tooth portions are so designed and arranged that when gear is rotated in clockwise direction, rotation is transmitted therefrom to gear 35 which is kept in meshing with a day star wheel 36, the latter being controlled in itsmovement by a jumper lever 44 as is known per
- Gear 34 meshes gear 38 which is rotatably mounted on a shaft 37.
- Gear 39 is rotatably mounted on the same shaft 37 and so designed and arranged that when gear 38 rotates in counter clockwise direction, rotation is transmitted to gear 39 through the intermeshing between ratchet tooth portions 38a and 39a.
- Gear 39 is kept in meshing with date display ring 40.
- gear 32 With the arrangement so far shown and described and with a clockwise rotation of gear 29, gear 32 is brought into meshing with gear 34, motion being thus transmitted through gear 35 to the day star wheel 36 for performing the desired correction of the day display.
- gear 32 With counter clockwise rotation of gear 29, gear 32 is shifted to a position shown at 32a so as to mesh with gear 42.
- Gear 42 is rotatably mounted on the shaft 41and a gear 43 is positioned on the gear 42 and rotatably mounted concentrically therewith.
- these related parts are so designed and arranged that only with counter clockwise rotation of gear 42, the correction force can be transmitted to date ring 40.
- the configuration and arrangement of the ratchet means are selected for satisfying these requirements.
- gear 32 With counter clockwise rotation of gear 29, gear 32 is shifted to a position shown at 32a and the correction force is transmitted through gears 42 and 43 to date ring 40.
- date ring 40 With either rotational direction of gear-29, date ring 40 is turned in its regular or forward direction and when a drive power is transmitted from the power spring or the like source to both the date ring and the day ring, gears 43, 35 and 39 are rotated in idle and rotation can not be transmitted to any other means not related therewith, thanks to the design and arrangement of the related ratchet means.
- Gear 50 is rotatably mounted on a shaft 52 and made with a gear 51 meshing with the day star wheel 36 controlled by a jumper lever 44 as conventionally.
- gear 45 With clockwise rotation of gear 29 and on account of that gears 29 and 45 have deeper dedendums, respectively, gear 45 is brought to a position shown at 45a, and gear 49 to a position shown at 49a. Thus, rotation is transmitted from gear 29 through gears at 45, 49, 53 and S5 to date ring 40 which is thus subjected to a correction as in the former way. Day ring is not affected in this case.
- gears 51 and 49 are also brought into rotation, but, the gear 49 is receded to the position at 49a so that no mechanical interference may be invited. Even with rotational movement of the date ring, a slip may be invited through the ratchet means provided between the related gears 55 and 53.
- FIGS. 5 and 6 the third embodiment of the invention will now be described.
- gear 29 With clockwise rotation of gear 29, motion is transmitted therefrom to a gear 58 which is rotatably mounted on a shaft 59 and provided on an arm 60 which is pivotable on the same shaft 59 rigid with the, plate.
- Shafts 61 and 62 are made rigid with arm 60 and gears 63 and 64 are rotatably mounted on these shafts, respectively.
- gear 64 is kept in meshing with gears 65 and 66 rotatably mounted on a shaft 68 made rigid with the plate 10.
- the ratchet means 66a; 67a are so designed and arranged that rotation is transmitted therethrough only with counterclockwise rotation of gear 65.
- Gear 65 meshes gear 67 through said ratchet means.
- Gear 65 is kept in meshing with gear 69 rotatably mounted on the shaft 70.
- Rotation is transmitted from gear 69, only when rotated in clockwise direction, through ratchet means 69a; 71a to gear 71 which is kept in meshing with date calendar ring 40.
- Calendar ring 40 and day star wheel 36 are controlled by jumper means as conventionally, although not specifically.
- gear 69 is kept in meshing with gear 65, but gear 64 does not act as a member of the related gear train, thus, no rotation being transmitted to the gear 66. It will be seen that in this case the correction is made only upon the date ring 40.
- Gear 29 is fixedly attached with gear 121 and an arm 122 is pivotably mounted on the shaft 25, said arm 122 fixedly mounting in turn a shaft 123 which mounts a gear 124 carrying thereon two pins 126a and 126b adapted for meshing with a date gear 125 having 31 gear teeth formed in its periphery.
- the lever 17 Under the regular working conditions of the timepiece, the lever 17 is brought to its counterclockwisely rotated position.
- the arm 122 is urged mechanically by contact with a pin 17d formed on the projecting part 17c of lever 17 so as to release the engagement between pins 126a; 126b and gear 125 and thus there may be a possibility of the engagement of gear 121 with day calendar ring 127. But, it may be observed that all the gears meshing with the gear 121 are kept in their free position, thus no mechanical interference being invited in this case.
- FIGS. 9 and 10 the fifth embodiment of the invention will be described in detail.
- the position shown in FIG. 9 is that for spring winding.
- Winding stem 128 mounts rotatably a winding pinion 129 and the conventional square section part of the stem 128 a conventional clutch wheel 130 is mounted nonrotatably, yet axially slidably.
- Clutch lever 132 urged resiliently by a conventional clutch lever spring 131 is kept by its projecting end in engagement with a ring groove formed on the stem 128 as before: Under normal operational conditions, therefore, the clutch wheel 130 is kept in engagement with the winding pinion 129.
- Rotation of the winding stem can be transmitted to a conventional crown wheel for winding the power spring, not shown. In this operational stage, it is natural that clutch wheel 130 is kept in disengagement from the setting wheel In FIG. 10, the quick-calender correcting position of the same embodiment is shown, being of the one step drawing out type.
- setting lever 134 With the winding stem 128 drawn out, setting lever 134 is rotatedin the counterclockwise direction and the projecting end shown at 134a of the lever will rise up along the convexly curved-surface shown at 132a of clutch lever, the latter being thereby urged to rotate in the counterclockwise direction so that clutch wheel 130 is brought into engagement with setting wheel 133 by virtue of the mechanical cooperation of the tip end of clutch lever 132 with a ring groove formed on the clutch wheel. At the same time, the engagement between winding pinion 129 and clutch wheel 130 is released.
- a spring 136 is provided for urging the lever at 135 pivoted on the setting'wheel shaft to rotate in clockwise direction.
- a gear 137 rotatably mounted on a shaft rigid with lever 135 is kept in engatement with setting wheel 133 and urged by a spring 136 against a gear 140 which is fitted with a further gear 139 kept in meshing with the day star wheel 138.
- a lever 141 is rotatably mounted on the shaft of gear 140 and mounts a further shaft mounting a gear 142 meshing with said gear 140.
- the gear 142 is so designed and arranged that with clockwise rotation of gear 140, the gear 143 fixed on gear 142 is brought into engagement with date ring 144 for the correction thereof, so that, in this case, the both calendars day and date, are subjected to correction simultaneously.
- gear 142 will escape or recede in the counter clockwise direction so that the gear 143 is released from engagement with date ring 144.
- correction is made only on through the day star wheel.
- both calendars are corrected, while with a reversed rotation of the stem, the clay calendar is corrected in the reverse sense.
- the shown position is that for time setting.
- the winding stem 128 has been brought to a still further drawn but second position.
- a pin l34b mounted on the setting lever 134 acts upon the lever to rotate it in counter clockwise direction against the action of spring 136 so that gear 137 is brought into engagement adapted for transmitting the rotation of setting wheel to minute wheel 145.
- the day calendar can be corrected in either direction, but the date calendar may be adjusted in one direction only, as was referred to hereinbefore in connection with the fourth to the fifth embodiment.
- the position shown in FIG. 12 is that for time setting and that shown in FIG. 13 is for calender correction.
- the full line position of the main working parts are those ready for for the spring winding operation, while the chain-dotted line position for the time setting.
- FIGS. 12 and 13 several working parts already described hereinbefore in connection with the first embodiment are represented with respective same reference numerals, each, however, attached with a prime.
- 12 represents a conventional setting lever; 12b a setting lever pin; 20 a pivot shaft thereof; 23 a setting lever spring; 23a a pivot shaft thereof; 230 a first elastic arm similar to that shown at 230 in the foregoing; 23d a second elastic arm similar to that shown at 23d in the foregoing; 24' a minute wheel; 29 a gear; 30 a pivotable lever similar to that shown at 30 in the foregoing; 32 an intermediate gear; 33' a shaft similar to that denoted 33 in the foregoing; 34 a gear,
- 35' a further gear; 36' a day star wheel; 40 a date calendar dial; and 44 ajumper lever for control ofstar wheel 36.
- the intermediate gear 29 mounted in the present embodiment on the changeoff lever 147 will occupy the shown position in which the latter is kept in separation from the gear 32.
- motion is transmitted therefrom to the gear 29 in the same manner as was referred to in the foregoing several embodiments, thus the gear 29' being kept in rotation at this stage, wherein the last-mentioned gear meshes a further intermediate gear 153 rotatably mounted on the plate.
- Motion is transmitted from gear 153 through minute wheel 24. and minute pinion 154 made rigid therewith.
- the minute pinion 154 rotates a conventional cannon wheel 155, thus the minute hand, not shown, is rotated as desired.
- change-off lever 147 is also rotated in clockwise direction so as to occupy its full line position.
- gear 29 is brought into meshing relation with gear 32 carrying rigidly thereon a pinion 156 which is now brought into engagement with an intermediate pinion 157 mounted rotatably on the plate, on account of the pinion 156 rotatably mounted on the lever 30'.
- Gear 157 is permanently kept in meshing with gear 34', a gear 35' serving as a driver for day calendar correction being coupled concentrically with the gear 34 through a friction coupling, although not specifically shown.
- the gear 35 is kept at this operational stage in meshing with the day star wheel 36'.
- the day calendar dial is corrected in one direction or in another direction, as the case may be, depending upon the rotational direction of the winding stem.
- a driving torque if applied from the regular gear train including cannon wheel 155, to star wheel 36', no day calendar correction will be invited, because such torque may be relieved through said friction coupling.
- an improved jumper lever 44' having two tooth projections 44'a and 44'b is arranged-to cooperate with the star wheel 36', so as to provide two holding positions to the wheel for providing two different day calendar displays, such as, for instance, expressed in English and German.
- Holding plate 159 is fixedly attached to the plate by means of a plurality of set screws of which only one is shown at 160, a spring arm 159a projecting the main part of the holding plate 159, so as to contact from upper with the pallet 243 so as to provide an axial pressure onto the one way clutch to keep it always in its ready-for-operational position.
- the pallet 243 For the regular drive of the date from the side of the normal gear train of the timepiece movement, the pallet 243 must be disengaged from the dial, in order to avoid an excess energy consumption of the drive poser source.
- an elongated spring arm 161 which is fixed at its root end to the holding plate 159, while the free end of the spring arm is kept in pressure contact with the tooth space on the pallet.
- a calendar timepiece comprising a rotatable date calendar ring, a rotatable day calendar ring, a rotatable winding stem and setting means operatively connected between said rings and said stem for imparting a correcting rotation to both of said rings simultaneously upon rotating said stem in one direction and for imparting a correcting rotation to only one of said rings by rotating said stem in the opposite direction
- said setting means comprises first and second date indexing means for indexing the date calendar ring and day indexing means for indexing the day calendar ring, a first transmission means for coupling the winding stem to the first date indexing means and the day indexing means upon rotation of said stem in the said one direction and a second transmission means for coupling the winding stem to the second date indexing means upon rotation of said winding stem in the said opposite direction.
- each of the transmission means includes a common gear operatively coupled to the winding stern during calendar ring setting and arranged for selective meshing with another gear of one of said first and second transmission means in dependence on the direction of rotation of the winding stem.
- a calendar timepiece comprising a rotatable date calendar ring, a rotatable day calendar ring, a rotatable winding stem and setting means operatively connected between said rings and said stem for imparting a correcting rotation to both of said rings simultaneously upon rotating said'stem in one direction and for imparting a correcting rotation to only one of said rings by rotating said stem in the opposite direction
- said setting means comprises a day indexing means for indexing the day calendar and a date indexing means being coupled to first and second gears respectively and a third gear 7 arranged to be coupled to the winding stem during the calendar ring setting.
- the setting means comprises fourth and .fifth meshing gears mounted on a common rotatable support, said fourth gear disposed in mesh with the third gear so that upon turning of the winding stem in the said one direction the support is rotated to a position in which the fourth gear meshes with the second and third gears and the fifth gear meshes with the first gear and upon turning of the winding stem in the said opposite direction the support is rotated to a position in which the fourth gear meshes with the third gear and the fifth gear meshes with the second gear.
- a calendar timepiece as claimed in claim 3 wherein the third gear is brought into mesh with the first and second gears during calendar ring resetting and wherein one of the indexing means is coupled to its associated gear of the first and second gears through a one-way clutch.
- a calendar timepiece as claimed in claim 7 wherein the setting means comprises a sun gear in mesh with said third gear and first and second planet gears in mesh with the sun gear and mounted on a support rotatable about the axis of the sun gear, said first and second planet gear being selectively brought into mesh with the first and second gears in dependence on the direction of turning of the winding stem during calendar ring setting.
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Electromechanical Clocks (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4844369A JPS4826791B1 (pt) | 1969-06-19 | 1969-06-19 | |
JP5816769U JPS4829485Y1 (pt) | 1969-06-19 | 1969-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3645090A true US3645090A (en) | 1972-02-29 |
Family
ID=26388715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US47701A Expired - Lifetime US3645090A (en) | 1969-06-19 | 1970-06-19 | Day-date quick-adjuster for calender timepiece |
Country Status (4)
Country | Link |
---|---|
US (1) | US3645090A (pt) |
DE (1) | DE2031216A1 (pt) |
FR (1) | FR2046920B1 (pt) |
GB (1) | GB1319315A (pt) |
Cited By (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3732687A (en) * | 1971-02-17 | 1973-05-15 | Citizen Watch Co Ltd | Calendar correction mechanism for timepiece |
US3748848A (en) * | 1971-10-29 | 1973-07-31 | Ebauches Sa | Day-date timepiece |
US3775965A (en) * | 1971-05-05 | 1973-12-04 | Ebauches Sa | Calendar timepiece |
US3779000A (en) * | 1971-10-06 | 1973-12-18 | Suisse Horlogerie | Correction device for day-and-date calendar watches |
US3969888A (en) * | 1972-12-11 | 1976-07-20 | Cyril Veuilleumier | Driving mechanism for day-date calendar device |
DE2824917A1 (de) | 1977-07-13 | 1979-02-01 | Corning Glass Works | Biologisch aktive konjugate |
WO1982000058A1 (en) * | 1980-06-20 | 1982-01-07 | Porter P | Processes and apparatus for carrying out specific binding assays |
US4443112A (en) * | 1982-09-29 | 1984-04-17 | Timex Corporation | Planetary gear for date mechanism in a wristwatch |
EP0253464A1 (en) | 1986-03-21 | 1988-01-20 | Hybritech Incorporated | Methods for providing internal references for use in analyte receptor assays |
WO2000073451A1 (en) | 1999-06-01 | 2000-12-07 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
WO2002020569A2 (en) | 2000-09-08 | 2002-03-14 | Schering Corporation | Mammalian genes; related reagents and methods |
WO2003030835A2 (en) | 2001-10-12 | 2003-04-17 | Schering Corporation | Use of bispecific antibodies to regulate immune responses |
US20030134794A1 (en) * | 2001-11-20 | 2003-07-17 | Madison Edwin L. | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
US6599727B1 (en) | 1999-06-16 | 2003-07-29 | Icos Corporation | Human poly (ADP-ribose) polymerase 2 materials and methods |
US20030180749A1 (en) * | 1999-10-13 | 2003-09-25 | Hubert Koster | Methods for generating databases and databases for identifying polymorphic genetic markers |
US20030232420A1 (en) * | 2002-05-03 | 2003-12-18 | Andreas Braun | Kinase anchor protein muteins, peptides thereof and related documents |
US20040001801A1 (en) * | 2002-05-23 | 2004-01-01 | Corvas International, Inc. | Conjugates activated by cell surface proteases and therapeutic uses thereof |
US20040229310A1 (en) * | 2003-01-23 | 2004-11-18 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
US20050153354A1 (en) * | 2004-01-13 | 2005-07-14 | U.S. Genomics, Inc. | Detection and quantification of analytes in solution using polymers |
WO2005105830A1 (en) | 2004-05-05 | 2005-11-10 | Valorisation-Recherche, Societe En Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
US20060014680A1 (en) * | 2004-07-13 | 2006-01-19 | Caiding Xu | Peptides and compounds that bind to the IL-5 receptor |
US20060099662A1 (en) * | 2004-04-16 | 2006-05-11 | Genentech, Inc. | Assay for antibodies |
US20060182716A1 (en) * | 2004-08-09 | 2006-08-17 | Jin Hong | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
US7105333B2 (en) | 2001-03-27 | 2006-09-12 | Deadreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon |
US20060204473A1 (en) * | 2004-08-09 | 2006-09-14 | Blatt Lawrence M | Synthetic hyperglycosylated, and hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same |
US7109299B1 (en) | 1999-12-16 | 2006-09-19 | Affymax, Inc. | Peptides and compounds that bind to the IL-5 receptor |
US7112430B2 (en) | 2001-05-14 | 2006-09-26 | Dendreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon |
US7125703B2 (en) | 2001-03-13 | 2006-10-24 | Dendreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon |
US7172892B2 (en) | 2001-03-22 | 2007-02-06 | Dendreon Corporation | Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon |
EP1798286A2 (en) | 1997-08-01 | 2007-06-20 | Schering Corporation | Mammalian cell membrane proteins and related reagents |
US20080031816A1 (en) * | 2006-08-03 | 2008-02-07 | Charles Keller | Methods and compositions for identifying biomarkers |
EP1897949A2 (en) | 1998-09-21 | 2008-03-12 | Schering Corporation | Human interleukin-B50. Therapeutic uses |
EP1908837A2 (en) | 2000-05-25 | 2008-04-09 | Schering Corporation | Human receptor proteins, related reagents and methods |
EP1916256A2 (en) | 2001-09-25 | 2008-04-30 | JAPAN as represented by PRESIDENT OF NATIONAL CANCER CENTER | Search for cancer markers by a novel screening method |
EP1918377A1 (en) | 2000-05-10 | 2008-05-07 | Schering Corporation | Mammalian cytokine receptor subunit proteins, related reagents and methods |
US20080171344A1 (en) * | 2006-12-22 | 2008-07-17 | Kapsner Kenneth P | Methods, Kits and Materials for Diagnosing Disease States by Measuring Isoforms or Proforms of Myeloperoxidase |
EP1947183A1 (en) | 1996-08-16 | 2008-07-23 | Schering Corporation | Mammalian cell surface antigens; related reagents |
EP1961760A2 (en) | 1995-06-07 | 2008-08-27 | Glaxo Group Limited | Peptides and compounds that bind to a thrombopoietin receptor |
EP1967203A1 (en) | 1998-07-15 | 2008-09-10 | The Brigham and Women's Hospital | Polysaccharide vaccine for staphylococcal infections |
EP1980573A2 (en) | 1997-07-09 | 2008-10-15 | Schering Corporation | Isolated dendritic cell membrane protein genes |
EP1983001A2 (en) | 1998-09-25 | 2008-10-22 | Schering Corporation | Antibodies to mammalian Langerhans cell antigen and their uses |
EP1988166A1 (en) | 1997-05-07 | 2008-11-05 | Schering Corporation | Human Toll-like receptor proteins, related reagents and methods |
EP1995317A1 (en) | 1996-12-13 | 2008-11-26 | Schering Corporation | Mammalian cell surface antigens; related reagents |
WO2008150525A1 (en) | 2007-06-04 | 2008-12-11 | Genentech, Inc. | Anti-notch1 nrr antibodies and methods using same |
EP2028191A1 (en) | 1996-12-11 | 2009-02-25 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US20090080600A1 (en) * | 2006-01-26 | 2009-03-26 | Charles Keller | Process and apparatus for imaging |
EP2065467A2 (en) | 2001-02-22 | 2009-06-03 | Genentech, Inc. | Anti-interferon-alpha antibodies |
EP2100959A2 (en) | 1997-07-25 | 2009-09-16 | Schering Corporation | Mammalian cytokine: interleukin-B30 and related reagents |
EP2138510A1 (en) | 1999-07-30 | 2009-12-30 | Schering Corporation | Methods of generating antibodies against cytokines |
US20100015654A1 (en) * | 2005-05-16 | 2010-01-21 | Institut De Recherches Cliniques De Montreal/ I.R.C.M. | Negative regulation of NK cell functions by EAT-2, a sap-related adaptor expressed in innate immune cells |
US20100035247A1 (en) * | 2005-11-04 | 2010-02-11 | U.S. Genomics, Inc. | Heterogeneous Assay of Analytes in Solution Using Polymers |
EP2256203A1 (en) | 2003-11-21 | 2010-12-01 | Schering Corporation | IL-23 and its receptor; related reagents and methods |
EP2292760A2 (en) | 2000-11-10 | 2011-03-09 | Schering Corporation | Mammalian cytokines, receptors, related reagents and methods |
WO2011057120A1 (en) | 2009-11-05 | 2011-05-12 | Genentech, Inc. | Methods and composition for secretion of heterologous polypeptides |
WO2011071577A1 (en) | 2009-12-11 | 2011-06-16 | Genentech, Inc. | Anti-vegf-c antibodies and methods using same |
EP2336321A1 (en) | 1999-05-13 | 2011-06-22 | Medical Research Council | Ox2 receptor homolog |
WO2011079185A1 (en) | 2009-12-23 | 2011-06-30 | Genentech, Inc. | Anti-bv8 antibodies and uses thereof |
EP2341144A1 (en) | 1999-01-11 | 2011-07-06 | Schering Corporation | Interleukin-17 related mammalian cytokines. Polynucleotides encoding them. Uses |
US20110183363A1 (en) * | 2009-10-26 | 2011-07-28 | Saloumeh Fischer | Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis |
EP2364994A1 (en) | 1994-01-05 | 2011-09-14 | Schering Corporation | Purfied primate CTLA-8 antigens and related reagents |
EP2366786A2 (en) | 2005-05-05 | 2011-09-21 | VALORISATION HSJ, Société en Commandite | Cytokine receptor modulators and uses thereof |
EP2402373A2 (en) | 2006-01-05 | 2012-01-04 | Genentech, Inc. | Anti-EphB4 Antibodies and Methods Using Same |
WO2012030738A2 (en) | 2010-08-30 | 2012-03-08 | Beckman Coulter, Inc. | Complex phosphoprotein activation profiles |
EP2457929A1 (en) | 2006-10-04 | 2012-05-30 | Genentech, Inc. | ELISA for VEGF |
EP2468772A2 (en) | 2006-03-16 | 2012-06-27 | Genentech, Inc. | Antibodies to EGFL7 and methods for their use |
WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
WO2012149320A1 (en) | 2011-04-29 | 2012-11-01 | Bristol-Myers Squibb Company | Ip-10 antibody dosage escalation regimens |
WO2013112912A1 (en) | 2012-01-26 | 2013-08-01 | Soares Christopher J | Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use |
WO2013142796A2 (en) | 2012-03-23 | 2013-09-26 | Bristol-Myers Squibb Company | Methods of treatments using ctla4 antibodies |
WO2013148373A1 (en) | 2012-03-28 | 2013-10-03 | Genentech, Inc. | Anti-hcmv idiotypic antibodies and uses thereof |
WO2013181348A1 (en) | 2012-05-30 | 2013-12-05 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions and methods of use |
WO2014036495A2 (en) | 2012-08-31 | 2014-03-06 | Immunogen Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
WO2015038884A2 (en) | 2013-09-13 | 2015-03-19 | Genentech, Inc. | Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products |
EP2851372A1 (en) | 2007-11-30 | 2015-03-25 | Genentech, Inc. | Anti-VEGF antibodies |
WO2015057402A1 (en) | 2013-10-18 | 2015-04-23 | University Health Network | Proteasome inhibition assay and methods of use |
WO2015139046A1 (en) | 2014-03-14 | 2015-09-17 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
EP2942357A1 (en) | 2008-08-04 | 2015-11-11 | Glen N. Barber | Sting (stimulator of inteferon genes), a regulator of innate immune responses |
WO2016069912A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules in vitro and in vivo |
WO2016069906A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
WO2016144824A1 (en) | 2015-03-06 | 2016-09-15 | Genentech, Inc. | Ultrapurified dsba and dsbc and methods of making and using the same |
US20160313698A1 (en) * | 2015-04-22 | 2016-10-27 | Seiko Epson Corporation | Timepiece and method for manufacturing timepiece |
WO2017040342A1 (en) | 2015-08-28 | 2017-03-09 | Genentech, Inc. | Anti-hypusine antibodies and uses thereof |
WO2017106527A1 (en) | 2015-12-15 | 2017-06-22 | Case Western Reserve University | Epithelial cancer evaluation using beta defensin |
WO2017178526A1 (en) | 2016-04-14 | 2017-10-19 | Lonza Ltd | Compositions and methods for the detection of host cell proteins |
US9920120B2 (en) | 2013-09-13 | 2018-03-20 | Genentech, Inc. | Methods and compositions comprising purified recombinant polypeptides |
WO2018136553A1 (en) | 2017-01-18 | 2018-07-26 | Genentech, Inc. | Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof |
EP3418740A1 (en) | 2012-11-07 | 2018-12-26 | Phoenix Tissue Repair, Inc. | Collagen iv binding assay for the detection of collagen vii |
EP3418299A1 (en) | 2007-09-14 | 2018-12-26 | Amgen Inc. | Homogeneous antibody populations |
US10281878B2 (en) * | 2016-10-28 | 2019-05-07 | Rolex Sa | Watch mechanism |
US10526418B2 (en) | 2012-02-16 | 2020-01-07 | The Penn State Research Foundation | Modulators of ACYL-COA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof |
US20210063966A1 (en) * | 2019-08-26 | 2021-03-04 | Blancpain Sa | Disengagement of two gear trains |
US11141423B2 (en) | 2010-01-25 | 2021-10-12 | Icahn School Of Medicine At Mount Sinai | Methods of screening compounds useful for treatment of a liver disease |
WO2021222333A1 (en) | 2020-04-30 | 2021-11-04 | Genentech, Inc. | Kras specific antibodies and uses thereof |
EP3925980A1 (en) | 2013-08-30 | 2021-12-22 | ImmunoGen, Inc. | Antibodies and assays for detection of folate receptor 1 |
WO2022081436A1 (en) | 2020-10-15 | 2022-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods |
WO2022087274A1 (en) | 2020-10-21 | 2022-04-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies that neutralize type-i interferon (ifn) activity |
WO2022178255A2 (en) | 2021-02-19 | 2022-08-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies that neutralize sars-cov-2 |
US11429066B2 (en) * | 2018-06-19 | 2022-08-30 | Sociéte anonyme de la manufacture d'horlogerie Audemars Piquet & Cie | Instantaneous control device for a date display of a timepiece |
US11435696B2 (en) * | 2017-07-25 | 2022-09-06 | Blancpain Sa | Torque smoothing for a timepiece, particularly with a striking mechanism |
US20220326658A1 (en) * | 2021-04-07 | 2022-10-13 | Manufacture D'horlogerie Audemars Piguet Sa | Selection and actuation device for a plurality of functions of a watch movement |
US11550267B2 (en) | 2017-03-22 | 2023-01-10 | Manufacture D'horlogerie Audemars Piguet Sa | Device for adjusting the functions of a timepiece |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3667435B1 (fr) * | 2018-12-10 | 2022-06-01 | Montres Breguet S.A. | Systeme de reglage de la position d'un premier mobile dente par rapport a un support sur lequel le premier mobile dente est monte pivotant et piece d'horlogerie comprenant un tel systeme |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470688A (en) * | 1967-07-26 | 1969-10-07 | Suwa Seikosha Kk | Date and day correcting device of a calendar timepiece |
US3470687A (en) * | 1966-12-15 | 1969-10-07 | Suwa Seikosha Kk | Date and day correcting device of a calendar timepiece |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH323982A (fr) * | 1955-07-23 | 1957-08-31 | Rolex Montres | Pièce d'horlogerie à calendrier |
CH394959A (fr) * | 1963-03-08 | 1965-03-15 | Tavannes Watch Co Sa | Montre à remontage automatique, comprenant un dispositif manuel de mise à l'heure et de remontage et un quantième |
DE1242512B (de) * | 1964-08-25 | 1967-06-15 | United States Time Corp | Anzeigevorrichtung an einer Uhr zum Anzeigen einer Vielzahl von Kalenderinformationen |
-
1970
- 1970-06-19 US US47701A patent/US3645090A/en not_active Expired - Lifetime
- 1970-06-19 GB GB2999970A patent/GB1319315A/en not_active Expired
- 1970-06-19 FR FR7022736A patent/FR2046920B1/fr not_active Expired
- 1970-06-19 DE DE19702031216 patent/DE2031216A1/de active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470687A (en) * | 1966-12-15 | 1969-10-07 | Suwa Seikosha Kk | Date and day correcting device of a calendar timepiece |
US3470688A (en) * | 1967-07-26 | 1969-10-07 | Suwa Seikosha Kk | Date and day correcting device of a calendar timepiece |
Cited By (163)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3732687A (en) * | 1971-02-17 | 1973-05-15 | Citizen Watch Co Ltd | Calendar correction mechanism for timepiece |
US3775965A (en) * | 1971-05-05 | 1973-12-04 | Ebauches Sa | Calendar timepiece |
US3779000A (en) * | 1971-10-06 | 1973-12-18 | Suisse Horlogerie | Correction device for day-and-date calendar watches |
US3748848A (en) * | 1971-10-29 | 1973-07-31 | Ebauches Sa | Day-date timepiece |
US3969888A (en) * | 1972-12-11 | 1976-07-20 | Cyril Veuilleumier | Driving mechanism for day-date calendar device |
DE2824917A1 (de) | 1977-07-13 | 1979-02-01 | Corning Glass Works | Biologisch aktive konjugate |
WO1982000058A1 (en) * | 1980-06-20 | 1982-01-07 | Porter P | Processes and apparatus for carrying out specific binding assays |
US4443112A (en) * | 1982-09-29 | 1984-04-17 | Timex Corporation | Planetary gear for date mechanism in a wristwatch |
EP0253464A1 (en) | 1986-03-21 | 1988-01-20 | Hybritech Incorporated | Methods for providing internal references for use in analyte receptor assays |
EP2364994A1 (en) | 1994-01-05 | 2011-09-14 | Schering Corporation | Purfied primate CTLA-8 antigens and related reagents |
EP2338897A1 (en) | 1995-06-07 | 2011-06-29 | Glaxo Group Limited | Peptides and compounds that bind to a thrombopoietin receptor |
EP1961760A2 (en) | 1995-06-07 | 2008-08-27 | Glaxo Group Limited | Peptides and compounds that bind to a thrombopoietin receptor |
EP1947183A1 (en) | 1996-08-16 | 2008-07-23 | Schering Corporation | Mammalian cell surface antigens; related reagents |
EP2336165A1 (en) | 1996-12-11 | 2011-06-22 | Glaxo Group Limited | Peptides and compounds that bind to the thrombopoietin receptor |
EP2028191A1 (en) | 1996-12-11 | 2009-02-25 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
EP1995318A1 (en) | 1996-12-13 | 2008-11-26 | Schering Corporation | Mammalian cell surface antigens; related reagents |
EP1995317A1 (en) | 1996-12-13 | 2008-11-26 | Schering Corporation | Mammalian cell surface antigens; related reagents |
EP1988166A1 (en) | 1997-05-07 | 2008-11-05 | Schering Corporation | Human Toll-like receptor proteins, related reagents and methods |
EP1980573A2 (en) | 1997-07-09 | 2008-10-15 | Schering Corporation | Isolated dendritic cell membrane protein genes |
EP2100959A2 (en) | 1997-07-25 | 2009-09-16 | Schering Corporation | Mammalian cytokine: interleukin-B30 and related reagents |
EP2233574A1 (en) | 1997-07-25 | 2010-09-29 | Schering Corporation | Mammalian cytokine: interleukin-B30 and related reagents |
EP1798287A2 (en) | 1997-08-01 | 2007-06-20 | Schering Corporation | Mammalian cell membrane proteins and related reagents |
EP1798286A2 (en) | 1997-08-01 | 2007-06-20 | Schering Corporation | Mammalian cell membrane proteins and related reagents |
EP1967203A1 (en) | 1998-07-15 | 2008-09-10 | The Brigham and Women's Hospital | Polysaccharide vaccine for staphylococcal infections |
EP2314696A1 (en) | 1998-09-21 | 2011-04-27 | Schering Corporation | Therapeutic uses of human Interleukin-B50 antagonist. |
EP1897949A2 (en) | 1998-09-21 | 2008-03-12 | Schering Corporation | Human interleukin-B50. Therapeutic uses |
EP1983001A2 (en) | 1998-09-25 | 2008-10-22 | Schering Corporation | Antibodies to mammalian Langerhans cell antigen and their uses |
EP2341144A1 (en) | 1999-01-11 | 2011-07-06 | Schering Corporation | Interleukin-17 related mammalian cytokines. Polynucleotides encoding them. Uses |
EP2341143A1 (en) | 1999-05-13 | 2011-07-06 | Medical Research Council | OX2 receptor homolog |
EP2336321A1 (en) | 1999-05-13 | 2011-06-22 | Medical Research Council | Ox2 receptor homolog |
WO2000073451A1 (en) | 1999-06-01 | 2000-12-07 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
EP2258849A1 (en) | 1999-06-01 | 2010-12-08 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
EP1950299A1 (en) | 1999-06-01 | 2008-07-30 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
US20030170859A1 (en) * | 1999-06-16 | 2003-09-11 | Erik Christenson | Human poly (ADP-ribose) polymerase 2 materials and methods |
US6989260B2 (en) | 1999-06-16 | 2006-01-24 | Icos Corporation | Human poly(ADP-ribose) polymerase 2 materials and methods |
US6599727B1 (en) | 1999-06-16 | 2003-07-29 | Icos Corporation | Human poly (ADP-ribose) polymerase 2 materials and methods |
EP2138510A1 (en) | 1999-07-30 | 2009-12-30 | Schering Corporation | Methods of generating antibodies against cytokines |
US20030180749A1 (en) * | 1999-10-13 | 2003-09-25 | Hubert Koster | Methods for generating databases and databases for identifying polymorphic genetic markers |
US7668658B2 (en) | 1999-10-13 | 2010-02-23 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
US8818735B2 (en) | 1999-10-13 | 2014-08-26 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
US8229677B2 (en) | 1999-10-13 | 2012-07-24 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
US20100292930A1 (en) * | 1999-10-13 | 2010-11-18 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
US7109299B1 (en) | 1999-12-16 | 2006-09-19 | Affymax, Inc. | Peptides and compounds that bind to the IL-5 receptor |
US7482433B2 (en) | 1999-12-16 | 2009-01-27 | Affymax, Inc. | Peptides and compounds that bind to the IL-5 receptor |
EP2275548A1 (en) | 2000-05-10 | 2011-01-19 | Schering Corporation | Mammalian cytokine receptor subunit proteins, related reagents and methods |
EP1918377A1 (en) | 2000-05-10 | 2008-05-07 | Schering Corporation | Mammalian cytokine receptor subunit proteins, related reagents and methods |
EP1908837A2 (en) | 2000-05-25 | 2008-04-09 | Schering Corporation | Human receptor proteins, related reagents and methods |
WO2002020569A2 (en) | 2000-09-08 | 2002-03-14 | Schering Corporation | Mammalian genes; related reagents and methods |
EP2298789A1 (en) | 2000-09-08 | 2011-03-23 | Schering Corporation | Mammalian genes; related reagents and methods |
EP2292760A2 (en) | 2000-11-10 | 2011-03-09 | Schering Corporation | Mammalian cytokines, receptors, related reagents and methods |
EP2292301A2 (en) | 2001-02-22 | 2011-03-09 | Genentech, Inc. | Anti-interferon-alpha antibodies |
EP2065467A2 (en) | 2001-02-22 | 2009-06-03 | Genentech, Inc. | Anti-interferon-alpha antibodies |
US7125703B2 (en) | 2001-03-13 | 2006-10-24 | Dendreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon |
US7172892B2 (en) | 2001-03-22 | 2007-02-06 | Dendreon Corporation | Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon |
US7105333B2 (en) | 2001-03-27 | 2006-09-12 | Deadreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon |
US7112430B2 (en) | 2001-05-14 | 2006-09-26 | Dendreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon |
EP1916256A2 (en) | 2001-09-25 | 2008-04-30 | JAPAN as represented by PRESIDENT OF NATIONAL CANCER CENTER | Search for cancer markers by a novel screening method |
EP2072059A1 (en) | 2001-10-12 | 2009-06-24 | Schering Corporation | Use of bispecific antibodies to regulate immune responses |
WO2003030835A2 (en) | 2001-10-12 | 2003-04-17 | Schering Corporation | Use of bispecific antibodies to regulate immune responses |
EP2316485A1 (en) | 2001-10-12 | 2011-05-04 | Schering Corporation | Use of bispecific antibodies to regulate immune responses |
US20030134794A1 (en) * | 2001-11-20 | 2003-07-17 | Madison Edwin L. | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
US20030232420A1 (en) * | 2002-05-03 | 2003-12-18 | Andreas Braun | Kinase anchor protein muteins, peptides thereof and related documents |
US7432342B2 (en) | 2002-05-03 | 2008-10-07 | Sequenom, Inc. | Kinase anchor protein muteins, peptides thereof and related documents |
US20090155846A1 (en) * | 2002-05-03 | 2009-06-18 | Sequenom, Inc. | Kinase anchor protein muteins, peptides thereof and related methods |
US20040001801A1 (en) * | 2002-05-23 | 2004-01-01 | Corvas International, Inc. | Conjugates activated by cell surface proteases and therapeutic uses thereof |
US7575893B2 (en) | 2003-01-23 | 2009-08-18 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
US20080187966A1 (en) * | 2003-01-23 | 2008-08-07 | Genentech, Inc. | Antibodies and methods for making and using them |
US20040229310A1 (en) * | 2003-01-23 | 2004-11-18 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
EP2256203A1 (en) | 2003-11-21 | 2010-12-01 | Schering Corporation | IL-23 and its receptor; related reagents and methods |
US20050153354A1 (en) * | 2004-01-13 | 2005-07-14 | U.S. Genomics, Inc. | Detection and quantification of analytes in solution using polymers |
US7977048B2 (en) | 2004-01-13 | 2011-07-12 | Pathogenetix, Inc. | Detection and quantification of analytes in solution using polymers |
US20080176257A9 (en) * | 2004-04-16 | 2008-07-24 | Genentech, Inc. | Assay for Antibodies |
US20070015228A1 (en) * | 2004-04-16 | 2007-01-18 | Genentech, Inc. | Assay for Antibodies |
US20060099662A1 (en) * | 2004-04-16 | 2006-05-11 | Genentech, Inc. | Assay for antibodies |
WO2005105830A1 (en) | 2004-05-05 | 2005-11-10 | Valorisation-Recherche, Societe En Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
US20060014680A1 (en) * | 2004-07-13 | 2006-01-19 | Caiding Xu | Peptides and compounds that bind to the IL-5 receptor |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
US20100099851A1 (en) * | 2004-08-09 | 2010-04-22 | Alios Biopharma, Inc. | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
US20060182716A1 (en) * | 2004-08-09 | 2006-08-17 | Jin Hong | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
US20060204473A1 (en) * | 2004-08-09 | 2006-09-14 | Blatt Lawrence M | Synthetic hyperglycosylated, and hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same |
EP2366786A2 (en) | 2005-05-05 | 2011-09-21 | VALORISATION HSJ, Société en Commandite | Cytokine receptor modulators and uses thereof |
US20100015654A1 (en) * | 2005-05-16 | 2010-01-21 | Institut De Recherches Cliniques De Montreal/ I.R.C.M. | Negative regulation of NK cell functions by EAT-2, a sap-related adaptor expressed in innate immune cells |
US20100035247A1 (en) * | 2005-11-04 | 2010-02-11 | U.S. Genomics, Inc. | Heterogeneous Assay of Analytes in Solution Using Polymers |
EP2402373A2 (en) | 2006-01-05 | 2012-01-04 | Genentech, Inc. | Anti-EphB4 Antibodies and Methods Using Same |
EP3156418A1 (en) | 2006-01-05 | 2017-04-19 | Genentech, Inc. | Anti-ephb4 antibodies and methods using same |
US20090080600A1 (en) * | 2006-01-26 | 2009-03-26 | Charles Keller | Process and apparatus for imaging |
US8189737B2 (en) | 2006-01-26 | 2012-05-29 | The Board Of Regents, The University Of Texas System, A Texas Institution Of Higher Learning | Process and apparatus for microCT imaging of ex vivo specimens |
US8553836B2 (en) | 2006-01-26 | 2013-10-08 | The Board Of Regents, The University Of Texas System | Process for producing a microCT image of a stained specimen |
EP2093235A1 (en) | 2006-02-08 | 2009-08-26 | Alios Biopharma Inc. | Hyperglycosylated variants of interferon alfacon-1 |
EP2468772A2 (en) | 2006-03-16 | 2012-06-27 | Genentech, Inc. | Antibodies to EGFL7 and methods for their use |
US20080031816A1 (en) * | 2006-08-03 | 2008-02-07 | Charles Keller | Methods and compositions for identifying biomarkers |
EP3103812A1 (en) | 2006-10-04 | 2016-12-14 | Genentech, Inc. | Elisa for vegf |
EP2457929A1 (en) | 2006-10-04 | 2012-05-30 | Genentech, Inc. | ELISA for VEGF |
US20080171344A1 (en) * | 2006-12-22 | 2008-07-17 | Kapsner Kenneth P | Methods, Kits and Materials for Diagnosing Disease States by Measuring Isoforms or Proforms of Myeloperoxidase |
WO2008150525A1 (en) | 2007-06-04 | 2008-12-11 | Genentech, Inc. | Anti-notch1 nrr antibodies and methods using same |
EP3418299A1 (en) | 2007-09-14 | 2018-12-26 | Amgen Inc. | Homogeneous antibody populations |
EP2851372A1 (en) | 2007-11-30 | 2015-03-25 | Genentech, Inc. | Anti-VEGF antibodies |
EP3173425A1 (en) | 2007-11-30 | 2017-05-31 | Genentech, Inc. | Anti-vegf antibodies |
EP2942357A1 (en) | 2008-08-04 | 2015-11-11 | Glen N. Barber | Sting (stimulator of inteferon genes), a regulator of innate immune responses |
US20110183363A1 (en) * | 2009-10-26 | 2011-07-28 | Saloumeh Fischer | Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis |
US9315583B2 (en) | 2009-10-26 | 2016-04-19 | Genentech, Inc. | Assays for detecting antibodies specific to therapeutic anti-IgE antibodies and their use in anaphylaxis |
WO2011057120A1 (en) | 2009-11-05 | 2011-05-12 | Genentech, Inc. | Methods and composition for secretion of heterologous polypeptides |
WO2011071577A1 (en) | 2009-12-11 | 2011-06-16 | Genentech, Inc. | Anti-vegf-c antibodies and methods using same |
WO2011079185A1 (en) | 2009-12-23 | 2011-06-30 | Genentech, Inc. | Anti-bv8 antibodies and uses thereof |
US11141423B2 (en) | 2010-01-25 | 2021-10-12 | Icahn School Of Medicine At Mount Sinai | Methods of screening compounds useful for treatment of a liver disease |
WO2012030738A2 (en) | 2010-08-30 | 2012-03-08 | Beckman Coulter, Inc. | Complex phosphoprotein activation profiles |
WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
WO2012149320A1 (en) | 2011-04-29 | 2012-11-01 | Bristol-Myers Squibb Company | Ip-10 antibody dosage escalation regimens |
WO2013112912A1 (en) | 2012-01-26 | 2013-08-01 | Soares Christopher J | Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use |
US10526418B2 (en) | 2012-02-16 | 2020-01-07 | The Penn State Research Foundation | Modulators of ACYL-COA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof |
WO2013142796A2 (en) | 2012-03-23 | 2013-09-26 | Bristol-Myers Squibb Company | Methods of treatments using ctla4 antibodies |
US20130266973A1 (en) * | 2012-03-28 | 2013-10-10 | Genentech, Inc. | Idiotypic antibodies and uses thereof |
US9139659B2 (en) * | 2012-03-28 | 2015-09-22 | Genentech, Inc. | Idiotypic antibodies and uses thereof |
WO2013148373A1 (en) | 2012-03-28 | 2013-10-03 | Genentech, Inc. | Anti-hcmv idiotypic antibodies and uses thereof |
WO2013181348A1 (en) | 2012-05-30 | 2013-12-05 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions and methods of use |
EP3712175A1 (en) | 2012-08-31 | 2020-09-23 | ImmunoGen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
WO2014036495A2 (en) | 2012-08-31 | 2014-03-06 | Immunogen Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
EP3418740A1 (en) | 2012-11-07 | 2018-12-26 | Phoenix Tissue Repair, Inc. | Collagen iv binding assay for the detection of collagen vii |
EP3925980A1 (en) | 2013-08-30 | 2021-12-22 | ImmunoGen, Inc. | Antibodies and assays for detection of folate receptor 1 |
US10597447B2 (en) | 2013-09-13 | 2020-03-24 | Genentech, Inc. | Compositions comprising purified recombinant IL-13 antibody |
US9945858B2 (en) | 2013-09-13 | 2018-04-17 | Genentech, Inc. | Compositions and methods for detecting and quantifying host cells protein in cell lines and recombinant polypeptide products |
US10494429B2 (en) | 2013-09-13 | 2019-12-03 | Genentech, Inc. | Compositions comprising purified anti-abeta monoclonal antibodies |
US11667706B2 (en) | 2013-09-13 | 2023-06-06 | Genentech, Inc. | Methods of purifying recombinant anti-abeta antibodies |
EP4163633A1 (en) | 2013-09-13 | 2023-04-12 | F. Hoffmann-La Roche AG | Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products |
US11519912B2 (en) | 2013-09-13 | 2022-12-06 | Genentech, Inc. | Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products |
US9920120B2 (en) | 2013-09-13 | 2018-03-20 | Genentech, Inc. | Methods and compositions comprising purified recombinant polypeptides |
US10597446B2 (en) | 2013-09-13 | 2020-03-24 | Genentech, Inc. | Method of treatment comprising purified recombinant IL-13 antibody |
US10822404B2 (en) | 2013-09-13 | 2020-11-03 | Genentech, Inc. | Methods and compositions comprising purified recombinant polypeptides |
WO2015038884A2 (en) | 2013-09-13 | 2015-03-19 | Genentech, Inc. | Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products |
US10788494B2 (en) | 2013-09-13 | 2020-09-29 | Genentech, Inc. | Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products |
WO2015057402A1 (en) | 2013-10-18 | 2015-04-23 | University Health Network | Proteasome inhibition assay and methods of use |
EP3360969A1 (en) | 2013-10-18 | 2018-08-15 | University Health Network | Proteasome inhibition assay and methods of use |
WO2015139046A1 (en) | 2014-03-14 | 2015-09-17 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
US12102691B2 (en) | 2014-10-29 | 2024-10-01 | Massachusetts Eye And Ear Infirmary | Methods for efficient delivery of therapeutic molecules in vitro and in vivo |
US11370823B2 (en) | 2014-10-29 | 2022-06-28 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
US12043653B2 (en) | 2014-10-29 | 2024-07-23 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
WO2016069910A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Methods for efficient delivery of therapeutic molecules in vitro and in vivo |
US11071790B2 (en) | 2014-10-29 | 2021-07-27 | Massachusetts Eye And Ear Infirmary | Method for efficient delivery of therapeutic molecules in vitro and in vivo |
WO2016069906A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
WO2016069912A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules in vitro and in vivo |
WO2016144824A1 (en) | 2015-03-06 | 2016-09-15 | Genentech, Inc. | Ultrapurified dsba and dsbc and methods of making and using the same |
US10690671B2 (en) | 2015-03-06 | 2020-06-23 | Genentech, Inc. | Ultrapurified DsbA and DsbC and methods of making and using the same |
EP3636749A1 (en) | 2015-03-06 | 2020-04-15 | F. Hoffmann-La Roche AG | Ultrapurified dsba and dsbc and methods of making and using the same |
US10073098B2 (en) | 2015-03-06 | 2018-09-11 | Genentech, Inc. | Ultrapurified DsbA and DsbC and methods of making and using the same |
US20160313698A1 (en) * | 2015-04-22 | 2016-10-27 | Seiko Epson Corporation | Timepiece and method for manufacturing timepiece |
US9791832B2 (en) * | 2015-04-22 | 2017-10-17 | Seiko Epson Corporation | Timepiece and method for manufacturing timepiece |
WO2017040342A1 (en) | 2015-08-28 | 2017-03-09 | Genentech, Inc. | Anti-hypusine antibodies and uses thereof |
EP3932953A1 (en) | 2015-08-28 | 2022-01-05 | F. Hoffmann-La Roche AG | Anti-hypusine antibodies and uses thereof |
WO2017106527A1 (en) | 2015-12-15 | 2017-06-22 | Case Western Reserve University | Epithelial cancer evaluation using beta defensin |
WO2017178526A1 (en) | 2016-04-14 | 2017-10-19 | Lonza Ltd | Compositions and methods for the detection of host cell proteins |
EP3683579A1 (en) | 2016-04-14 | 2020-07-22 | Lonza Ltd | Compositions and methods for the detection of host cell proteins |
US10281878B2 (en) * | 2016-10-28 | 2019-05-07 | Rolex Sa | Watch mechanism |
WO2018136553A1 (en) | 2017-01-18 | 2018-07-26 | Genentech, Inc. | Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof |
US11550267B2 (en) | 2017-03-22 | 2023-01-10 | Manufacture D'horlogerie Audemars Piguet Sa | Device for adjusting the functions of a timepiece |
US11435696B2 (en) * | 2017-07-25 | 2022-09-06 | Blancpain Sa | Torque smoothing for a timepiece, particularly with a striking mechanism |
US11429066B2 (en) * | 2018-06-19 | 2022-08-30 | Sociéte anonyme de la manufacture d'horlogerie Audemars Piquet & Cie | Instantaneous control device for a date display of a timepiece |
US11733654B2 (en) * | 2019-08-26 | 2023-08-22 | Omega Sa | Disengagement of two gear trains |
US20210063966A1 (en) * | 2019-08-26 | 2021-03-04 | Blancpain Sa | Disengagement of two gear trains |
WO2021222333A1 (en) | 2020-04-30 | 2021-11-04 | Genentech, Inc. | Kras specific antibodies and uses thereof |
WO2022081436A1 (en) | 2020-10-15 | 2022-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods |
WO2022087274A1 (en) | 2020-10-21 | 2022-04-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies that neutralize type-i interferon (ifn) activity |
WO2022178255A2 (en) | 2021-02-19 | 2022-08-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies that neutralize sars-cov-2 |
US20220326658A1 (en) * | 2021-04-07 | 2022-10-13 | Manufacture D'horlogerie Audemars Piguet Sa | Selection and actuation device for a plurality of functions of a watch movement |
Also Published As
Publication number | Publication date |
---|---|
FR2046920A1 (pt) | 1971-03-12 |
FR2046920B1 (pt) | 1974-05-03 |
DE2031216A1 (de) | 1971-01-14 |
GB1319315A (en) | 1973-06-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3645090A (en) | Day-date quick-adjuster for calender timepiece | |
KR101280644B1 (ko) | 변수의 이산 값의 주기를 디스플레이하기 위한 기계 장치 | |
GB1140930A (en) | Calendar timepiece | |
JP2003315473A (ja) | 細長い形状のケースを含む時計 | |
US3748848A (en) | Day-date timepiece | |
US3842590A (en) | Calendar timepiece | |
US11543778B2 (en) | Adjustment mechanism for timepiece display mechanism with rollers | |
GB1373838A (en) | Calendar correction mechanism for a timepiece | |
US3765162A (en) | Watch indicating many times | |
US3668864A (en) | Calendar watch setting stem with displaceable spring biased gear | |
US3798893A (en) | Day-and-date changing device for a wristwatch | |
CN111338200B (zh) | 一种中心指针式日历和大月相显示机构 | |
US3703805A (en) | Electric timepiece with date dial | |
US3691756A (en) | Date and day correcting device | |
US3855785A (en) | Calendar correcting device for timepiece | |
US3597916A (en) | Day and date corrector mechanism for a watch | |
US2790300A (en) | Calendar clock | |
US3969888A (en) | Driving mechanism for day-date calendar device | |
US3248868A (en) | Setting means for a date timepiece | |
US3695029A (en) | Calendar day and date watch | |
GB1205962A (en) | Calendar timepiece setting mechanism | |
US2591819A (en) | Calendar timepiece | |
US3762151A (en) | Time-detecting system for a digital interval timer | |
US3456516A (en) | Incremental drive mechanism | |
US3866408A (en) | Timepiece setting mechanism |