US3645090A - Day-date quick-adjuster for calender timepiece - Google Patents

Day-date quick-adjuster for calender timepiece Download PDF

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Publication number
US3645090A
US3645090A US47701A US3645090DA US3645090A US 3645090 A US3645090 A US 3645090A US 47701 A US47701 A US 47701A US 3645090D A US3645090D A US 3645090DA US 3645090 A US3645090 A US 3645090A
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United States
Prior art keywords
gear
calendar
stem
day
date
Prior art date
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Expired - Lifetime
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US47701A
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English (en)
Inventor
Yoshifumi Mochizuki
Akira Tsuzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Citizen Watch Co Ltd
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Citizen Watch Co Ltd
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Publication date
Priority claimed from JP4844369A external-priority patent/JPS4826791B1/ja
Priority claimed from JP5816769U external-priority patent/JPS4829485Y1/ja
Application filed by Citizen Watch Co Ltd filed Critical Citizen Watch Co Ltd
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Publication of US3645090A publication Critical patent/US3645090A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G04—HOROLOGY
    • G04B—MECHANICALLY-DRIVEN CLOCKS OR WATCHES; MECHANICAL PARTS OF CLOCKS OR WATCHES IN GENERAL; TIME PIECES USING THE POSITION OF THE SUN, MOON OR STARS
    • G04B19/00—Indicating the time by visual means
    • G04B19/24—Clocks or watches with date or week-day indicators, i.e. calendar clocks or watches; Clockwork calendars
    • G04B19/243—Clocks or watches with date or week-day indicators, i.e. calendar clocks or watches; Clockwork calendars characterised by the shape of the date indicator
    • G04B19/247—Clocks or watches with date or week-day indicators, i.e. calendar clocks or watches; Clockwork calendars characterised by the shape of the date indicator disc-shaped
    • G04B19/25—Devices for setting the date indicators manually
    • G—PHYSICS
    • G04—HOROLOGY
    • G04B—MECHANICALLY-DRIVEN CLOCKS OR WATCHES; MECHANICAL PARTS OF CLOCKS OR WATCHES IN GENERAL; TIME PIECES USING THE POSITION OF THE SUN, MOON OR STARS
    • G04B11/00—Click devices; Stop clicks; Clutches
    • G04B11/006—Clutch mechanism between two rotating members with transfer of movement in only one direction (free running devices)

Definitions

  • the correction torque transmitting arrangement is so designed that by turning said stem in one direction both calendar dials are rotated for correction in unison with each other and by turning the stem in the opposite direction only one of the dials is rotated independently from the other and in the same direction as before when the stem was rotated in said one direction.
  • The'present invention relates broadly with improvement in and relating to calendar timepieces. More specifically, it relates to a quick-calendar correction mechanism for use with the timepiece of the above kind having a date calendar dial and a, day calendar dial operable independently from each other.
  • One of recently advanced day and date calendar correction mechanisms is constructed so that by turning the conventional winding stem in one direction upon preparatory positioning thereof in its quick calendar correcting position, either of the both calendar displays is subjected correction and by turning the stern in the reverse direction the remaining calendar display is corrected.
  • the winding stern must be rotated for performing one kind of calendar correction at first in one direction and then in the opposite direction for performing the remaining kind of calendar correction. Therefore, with use of the prior advanced correction mechanism, two successive operations must be adopted for carrying out the day and date calendar corrections.
  • a still further object of the invention is to provide a calendar correction mechanism of the above kind, capable of providing the ability to correct the day calendar display in the reverse direction for attaining an easier and quicker day correction at the end ofa small month.
  • F I0, I is a schematic plan view of a preferred first embodiment of the invention.
  • FIG. 2 is a sectional view taken substantially along a section line A,-A' shown in FIG. 1.
  • F IG; 3 is a sectional view taken substantially along a section line 8-8 shown in FIG. 1.
  • FIGS. 4 and 5 are plan views of several main working parts of preferred second and third embodiments of the invention, respectively.
  • FIG.v 6 is a sectional view taken substantially along a section line C-C' shown in FIG. 5.
  • FIG. 7 is a schematic plan view of a fourth embodiment of the invention.
  • F IG. 8 is a sectional view taken substantially along a section line D D' in FIG. 7.
  • FIGS. 9 and 10 are schematic plan views of two different working modes of a preferred embodiment of the invention.
  • F IO. 11 is a similar view to FIG. 9, illustrative of the time setting position of the fifth embodiment. 7
  • FIGS. 12 and 13 are plan views of a sixth embodiment of the invention, illustrative of different operating positions of the mechanism.
  • the numeral 10 represents a conventional plate of a timepiece movement and a conventional winding stem 11 is rotatably and slidably mounted in the plate.v
  • the stem 11 is formed with a ring groove Ila with which a projection 12a of a setting lever 12 is kept in engagement as conventionally for the prevention of otherwise possible slip-out of the stem from position.
  • Winding stem 11 carries a winding pinion l3 and a clutch wheel 14 having a gear portion 140 made integral therewith, as conventionally.
  • Winding position 13 is slidable in the axial direction of the stem II and rotatable relative thereto, while clutch wheel 14 is arranged only slidable longitudinally of the stem, thus being rotatable in unison with the latter.
  • Clutch wheel 14 is formed on its cylindrical peripheral surface with a ring groove 14b with which one end of clutch lever 15 is engaged, the latter lever being movable in unison with the push-in and drawout manual operation applied to the winding stem 11 by receiving motion therefrom through the setting lever 12.
  • clutch wheel 14 having a tooth portion 14c being kept in its disengaged position with the tooth portion at 13a formed on the winding pinion I3.
  • setting wheel 16 mounted rotatably on a stationary shaft portion 10a formed on the plate 10 is kept again in its disengaged position, as shown, with the toothed portion at of clutch wheel 14.
  • the clutch wheel 14 is so positioned, as shown, in a stabilized way that its toothed portion 14a is positively kept in engagement with a gear which is rigid with a shaft 19 rotatably mounted in a lever 17.
  • setting lever 12 is rotatably mounted around a shaft 20 which is rigid with the plate 10
  • clutch lever 15 is rotatably mounted on its shaft 21 which is also rigid with the plate.
  • a conventional clutch lever spring 22 urges the clutch lever 15 so as to establish a pressure contact thereof with setting lever 12.
  • Numeral 23 represents a conventional setting lever spring the main nonelastic part of which is fixed onto the plate 10 by means of setting screws 23a and 23b.
  • Setting lever spring 23 comprises an elastic arm 23c which is kept .in pressure. contact with setting lever pin 12b.
  • Setting lever spring 23 is formed with an elastic arm 23d whichexerts a resilient pressure upon the setting lever 12 for keeping the latter in position within the timepiece movement.
  • Setting wheel 16 is kept in meshing with minute wheel 24.
  • the lever 17 is rotatably mounted on a shaft 25 which is rigid with the plate 10, said lever 17 being abutting under pressure against the setting lever pin 12b under the influence of a bar spring 26 which is shown only partially for simplicity of the drawing. Although not shown, this bar spring 26 is mounted at its root portion fixedly on the plate 10.
  • lever 17 Since the lever 17 is kept in a positive pressure engagement with the setting lever 12b and movable in the counter clockwise direction in FIG. 1 irrespective of occasional and selective moving direction of the lever 12 caused by a push-in or drawout operation applied to the winding stem, indeed, by the intimate and positive cooperating engagement of cam parts 17a; 17b of the setting lever pin 17b.
  • a gear 28 is rotatably mounted around a shaft 27 which is rigid with the lever, said gear 28 meshing with said gear 18.
  • gear 29 On the same lever 17, there is a further gear 29 which is rotatable around a shaft rigid with the said lever.
  • a further lever 30 is also mounted rotatable on the same shaft 25, a further shaft 31 being fixedly mounted on the said lever 30 and a further gear 32 being rotatably mounted on the shaft 31 and meshing with gear 29'.
  • gear 29 rotates in clockwise direction in FIG. 1
  • lever 30 is subjected to a .mechanical urging force acting in clockwise direction and gear 32 is brought into meshing with gear 34 which is rotatably mounted on the shaft at 33.
  • gear 34 meshes at its ratchet tooth portion 34a with that shown at 35a of gear 35 which is rotatably mounted on the shaft 33.
  • These ratchet tooth portions are so designed and arranged that when gear is rotated in clockwise direction, rotation is transmitted therefrom to gear 35 which is kept in meshing with a day star wheel 36, the latter being controlled in itsmovement by a jumper lever 44 as is known per
  • Gear 34 meshes gear 38 which is rotatably mounted on a shaft 37.
  • Gear 39 is rotatably mounted on the same shaft 37 and so designed and arranged that when gear 38 rotates in counter clockwise direction, rotation is transmitted to gear 39 through the intermeshing between ratchet tooth portions 38a and 39a.
  • Gear 39 is kept in meshing with date display ring 40.
  • gear 32 With the arrangement so far shown and described and with a clockwise rotation of gear 29, gear 32 is brought into meshing with gear 34, motion being thus transmitted through gear 35 to the day star wheel 36 for performing the desired correction of the day display.
  • gear 32 With counter clockwise rotation of gear 29, gear 32 is shifted to a position shown at 32a so as to mesh with gear 42.
  • Gear 42 is rotatably mounted on the shaft 41and a gear 43 is positioned on the gear 42 and rotatably mounted concentrically therewith.
  • these related parts are so designed and arranged that only with counter clockwise rotation of gear 42, the correction force can be transmitted to date ring 40.
  • the configuration and arrangement of the ratchet means are selected for satisfying these requirements.
  • gear 32 With counter clockwise rotation of gear 29, gear 32 is shifted to a position shown at 32a and the correction force is transmitted through gears 42 and 43 to date ring 40.
  • date ring 40 With either rotational direction of gear-29, date ring 40 is turned in its regular or forward direction and when a drive power is transmitted from the power spring or the like source to both the date ring and the day ring, gears 43, 35 and 39 are rotated in idle and rotation can not be transmitted to any other means not related therewith, thanks to the design and arrangement of the related ratchet means.
  • Gear 50 is rotatably mounted on a shaft 52 and made with a gear 51 meshing with the day star wheel 36 controlled by a jumper lever 44 as conventionally.
  • gear 45 With clockwise rotation of gear 29 and on account of that gears 29 and 45 have deeper dedendums, respectively, gear 45 is brought to a position shown at 45a, and gear 49 to a position shown at 49a. Thus, rotation is transmitted from gear 29 through gears at 45, 49, 53 and S5 to date ring 40 which is thus subjected to a correction as in the former way. Day ring is not affected in this case.
  • gears 51 and 49 are also brought into rotation, but, the gear 49 is receded to the position at 49a so that no mechanical interference may be invited. Even with rotational movement of the date ring, a slip may be invited through the ratchet means provided between the related gears 55 and 53.
  • FIGS. 5 and 6 the third embodiment of the invention will now be described.
  • gear 29 With clockwise rotation of gear 29, motion is transmitted therefrom to a gear 58 which is rotatably mounted on a shaft 59 and provided on an arm 60 which is pivotable on the same shaft 59 rigid with the, plate.
  • Shafts 61 and 62 are made rigid with arm 60 and gears 63 and 64 are rotatably mounted on these shafts, respectively.
  • gear 64 is kept in meshing with gears 65 and 66 rotatably mounted on a shaft 68 made rigid with the plate 10.
  • the ratchet means 66a; 67a are so designed and arranged that rotation is transmitted therethrough only with counterclockwise rotation of gear 65.
  • Gear 65 meshes gear 67 through said ratchet means.
  • Gear 65 is kept in meshing with gear 69 rotatably mounted on the shaft 70.
  • Rotation is transmitted from gear 69, only when rotated in clockwise direction, through ratchet means 69a; 71a to gear 71 which is kept in meshing with date calendar ring 40.
  • Calendar ring 40 and day star wheel 36 are controlled by jumper means as conventionally, although not specifically.
  • gear 69 is kept in meshing with gear 65, but gear 64 does not act as a member of the related gear train, thus, no rotation being transmitted to the gear 66. It will be seen that in this case the correction is made only upon the date ring 40.
  • Gear 29 is fixedly attached with gear 121 and an arm 122 is pivotably mounted on the shaft 25, said arm 122 fixedly mounting in turn a shaft 123 which mounts a gear 124 carrying thereon two pins 126a and 126b adapted for meshing with a date gear 125 having 31 gear teeth formed in its periphery.
  • the lever 17 Under the regular working conditions of the timepiece, the lever 17 is brought to its counterclockwisely rotated position.
  • the arm 122 is urged mechanically by contact with a pin 17d formed on the projecting part 17c of lever 17 so as to release the engagement between pins 126a; 126b and gear 125 and thus there may be a possibility of the engagement of gear 121 with day calendar ring 127. But, it may be observed that all the gears meshing with the gear 121 are kept in their free position, thus no mechanical interference being invited in this case.
  • FIGS. 9 and 10 the fifth embodiment of the invention will be described in detail.
  • the position shown in FIG. 9 is that for spring winding.
  • Winding stem 128 mounts rotatably a winding pinion 129 and the conventional square section part of the stem 128 a conventional clutch wheel 130 is mounted nonrotatably, yet axially slidably.
  • Clutch lever 132 urged resiliently by a conventional clutch lever spring 131 is kept by its projecting end in engagement with a ring groove formed on the stem 128 as before: Under normal operational conditions, therefore, the clutch wheel 130 is kept in engagement with the winding pinion 129.
  • Rotation of the winding stem can be transmitted to a conventional crown wheel for winding the power spring, not shown. In this operational stage, it is natural that clutch wheel 130 is kept in disengagement from the setting wheel In FIG. 10, the quick-calender correcting position of the same embodiment is shown, being of the one step drawing out type.
  • setting lever 134 With the winding stem 128 drawn out, setting lever 134 is rotatedin the counterclockwise direction and the projecting end shown at 134a of the lever will rise up along the convexly curved-surface shown at 132a of clutch lever, the latter being thereby urged to rotate in the counterclockwise direction so that clutch wheel 130 is brought into engagement with setting wheel 133 by virtue of the mechanical cooperation of the tip end of clutch lever 132 with a ring groove formed on the clutch wheel. At the same time, the engagement between winding pinion 129 and clutch wheel 130 is released.
  • a spring 136 is provided for urging the lever at 135 pivoted on the setting'wheel shaft to rotate in clockwise direction.
  • a gear 137 rotatably mounted on a shaft rigid with lever 135 is kept in engatement with setting wheel 133 and urged by a spring 136 against a gear 140 which is fitted with a further gear 139 kept in meshing with the day star wheel 138.
  • a lever 141 is rotatably mounted on the shaft of gear 140 and mounts a further shaft mounting a gear 142 meshing with said gear 140.
  • the gear 142 is so designed and arranged that with clockwise rotation of gear 140, the gear 143 fixed on gear 142 is brought into engagement with date ring 144 for the correction thereof, so that, in this case, the both calendars day and date, are subjected to correction simultaneously.
  • gear 142 will escape or recede in the counter clockwise direction so that the gear 143 is released from engagement with date ring 144.
  • correction is made only on through the day star wheel.
  • both calendars are corrected, while with a reversed rotation of the stem, the clay calendar is corrected in the reverse sense.
  • the shown position is that for time setting.
  • the winding stem 128 has been brought to a still further drawn but second position.
  • a pin l34b mounted on the setting lever 134 acts upon the lever to rotate it in counter clockwise direction against the action of spring 136 so that gear 137 is brought into engagement adapted for transmitting the rotation of setting wheel to minute wheel 145.
  • the day calendar can be corrected in either direction, but the date calendar may be adjusted in one direction only, as was referred to hereinbefore in connection with the fourth to the fifth embodiment.
  • the position shown in FIG. 12 is that for time setting and that shown in FIG. 13 is for calender correction.
  • the full line position of the main working parts are those ready for for the spring winding operation, while the chain-dotted line position for the time setting.
  • FIGS. 12 and 13 several working parts already described hereinbefore in connection with the first embodiment are represented with respective same reference numerals, each, however, attached with a prime.
  • 12 represents a conventional setting lever; 12b a setting lever pin; 20 a pivot shaft thereof; 23 a setting lever spring; 23a a pivot shaft thereof; 230 a first elastic arm similar to that shown at 230 in the foregoing; 23d a second elastic arm similar to that shown at 23d in the foregoing; 24' a minute wheel; 29 a gear; 30 a pivotable lever similar to that shown at 30 in the foregoing; 32 an intermediate gear; 33' a shaft similar to that denoted 33 in the foregoing; 34 a gear,
  • 35' a further gear; 36' a day star wheel; 40 a date calendar dial; and 44 ajumper lever for control ofstar wheel 36.
  • the intermediate gear 29 mounted in the present embodiment on the changeoff lever 147 will occupy the shown position in which the latter is kept in separation from the gear 32.
  • motion is transmitted therefrom to the gear 29 in the same manner as was referred to in the foregoing several embodiments, thus the gear 29' being kept in rotation at this stage, wherein the last-mentioned gear meshes a further intermediate gear 153 rotatably mounted on the plate.
  • Motion is transmitted from gear 153 through minute wheel 24. and minute pinion 154 made rigid therewith.
  • the minute pinion 154 rotates a conventional cannon wheel 155, thus the minute hand, not shown, is rotated as desired.
  • change-off lever 147 is also rotated in clockwise direction so as to occupy its full line position.
  • gear 29 is brought into meshing relation with gear 32 carrying rigidly thereon a pinion 156 which is now brought into engagement with an intermediate pinion 157 mounted rotatably on the plate, on account of the pinion 156 rotatably mounted on the lever 30'.
  • Gear 157 is permanently kept in meshing with gear 34', a gear 35' serving as a driver for day calendar correction being coupled concentrically with the gear 34 through a friction coupling, although not specifically shown.
  • the gear 35 is kept at this operational stage in meshing with the day star wheel 36'.
  • the day calendar dial is corrected in one direction or in another direction, as the case may be, depending upon the rotational direction of the winding stem.
  • a driving torque if applied from the regular gear train including cannon wheel 155, to star wheel 36', no day calendar correction will be invited, because such torque may be relieved through said friction coupling.
  • an improved jumper lever 44' having two tooth projections 44'a and 44'b is arranged-to cooperate with the star wheel 36', so as to provide two holding positions to the wheel for providing two different day calendar displays, such as, for instance, expressed in English and German.
  • Holding plate 159 is fixedly attached to the plate by means of a plurality of set screws of which only one is shown at 160, a spring arm 159a projecting the main part of the holding plate 159, so as to contact from upper with the pallet 243 so as to provide an axial pressure onto the one way clutch to keep it always in its ready-for-operational position.
  • the pallet 243 For the regular drive of the date from the side of the normal gear train of the timepiece movement, the pallet 243 must be disengaged from the dial, in order to avoid an excess energy consumption of the drive poser source.
  • an elongated spring arm 161 which is fixed at its root end to the holding plate 159, while the free end of the spring arm is kept in pressure contact with the tooth space on the pallet.
  • a calendar timepiece comprising a rotatable date calendar ring, a rotatable day calendar ring, a rotatable winding stem and setting means operatively connected between said rings and said stem for imparting a correcting rotation to both of said rings simultaneously upon rotating said stem in one direction and for imparting a correcting rotation to only one of said rings by rotating said stem in the opposite direction
  • said setting means comprises first and second date indexing means for indexing the date calendar ring and day indexing means for indexing the day calendar ring, a first transmission means for coupling the winding stem to the first date indexing means and the day indexing means upon rotation of said stem in the said one direction and a second transmission means for coupling the winding stem to the second date indexing means upon rotation of said winding stem in the said opposite direction.
  • each of the transmission means includes a common gear operatively coupled to the winding stern during calendar ring setting and arranged for selective meshing with another gear of one of said first and second transmission means in dependence on the direction of rotation of the winding stem.
  • a calendar timepiece comprising a rotatable date calendar ring, a rotatable day calendar ring, a rotatable winding stem and setting means operatively connected between said rings and said stem for imparting a correcting rotation to both of said rings simultaneously upon rotating said'stem in one direction and for imparting a correcting rotation to only one of said rings by rotating said stem in the opposite direction
  • said setting means comprises a day indexing means for indexing the day calendar and a date indexing means being coupled to first and second gears respectively and a third gear 7 arranged to be coupled to the winding stem during the calendar ring setting.
  • the setting means comprises fourth and .fifth meshing gears mounted on a common rotatable support, said fourth gear disposed in mesh with the third gear so that upon turning of the winding stem in the said one direction the support is rotated to a position in which the fourth gear meshes with the second and third gears and the fifth gear meshes with the first gear and upon turning of the winding stem in the said opposite direction the support is rotated to a position in which the fourth gear meshes with the third gear and the fifth gear meshes with the second gear.
  • a calendar timepiece as claimed in claim 3 wherein the third gear is brought into mesh with the first and second gears during calendar ring resetting and wherein one of the indexing means is coupled to its associated gear of the first and second gears through a one-way clutch.
  • a calendar timepiece as claimed in claim 7 wherein the setting means comprises a sun gear in mesh with said third gear and first and second planet gears in mesh with the sun gear and mounted on a support rotatable about the axis of the sun gear, said first and second planet gear being selectively brought into mesh with the first and second gears in dependence on the direction of turning of the winding stem during calendar ring setting.
US47701A 1969-06-19 1970-06-19 Day-date quick-adjuster for calender timepiece Expired - Lifetime US3645090A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4844369A JPS4826791B1 (de) 1969-06-19 1969-06-19
JP5816769U JPS4829485Y1 (de) 1969-06-19 1969-06-19

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US (1) US3645090A (de)
DE (1) DE2031216A1 (de)
FR (1) FR2046920B1 (de)
GB (1) GB1319315A (de)

Cited By (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732687A (en) * 1971-02-17 1973-05-15 Citizen Watch Co Ltd Calendar correction mechanism for timepiece
US3748848A (en) * 1971-10-29 1973-07-31 Ebauches Sa Day-date timepiece
US3775965A (en) * 1971-05-05 1973-12-04 Ebauches Sa Calendar timepiece
US3779000A (en) * 1971-10-06 1973-12-18 Suisse Horlogerie Correction device for day-and-date calendar watches
US3969888A (en) * 1972-12-11 1976-07-20 Cyril Veuilleumier Driving mechanism for day-date calendar device
DE2824917A1 (de) 1977-07-13 1979-02-01 Corning Glass Works Biologisch aktive konjugate
WO1982000058A1 (en) * 1980-06-20 1982-01-07 Porter P Processes and apparatus for carrying out specific binding assays
US4443112A (en) * 1982-09-29 1984-04-17 Timex Corporation Planetary gear for date mechanism in a wristwatch
EP0253464A1 (de) 1986-03-21 1988-01-20 Hybritech Incorporated Verfahren für die Beschaffung interner Referenzen zur Verwendung in Analyt-Rezeptor-Tests
WO2000073451A1 (en) 1999-06-01 2000-12-07 Schering Corporation Mammalian receptor proteins; related reagents and methods
WO2002020569A2 (en) 2000-09-08 2002-03-14 Schering Corporation Mammalian genes; related reagents and methods
WO2003030835A2 (en) 2001-10-12 2003-04-17 Schering Corporation Use of bispecific antibodies to regulate immune responses
US20030134794A1 (en) * 2001-11-20 2003-07-17 Madison Edwin L. Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon
US6599727B1 (en) 1999-06-16 2003-07-29 Icos Corporation Human poly (ADP-ribose) polymerase 2 materials and methods
US20030180749A1 (en) * 1999-10-13 2003-09-25 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
US20030232420A1 (en) * 2002-05-03 2003-12-18 Andreas Braun Kinase anchor protein muteins, peptides thereof and related documents
US20040001801A1 (en) * 2002-05-23 2004-01-01 Corvas International, Inc. Conjugates activated by cell surface proteases and therapeutic uses thereof
US20040229310A1 (en) * 2003-01-23 2004-11-18 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
US20050153354A1 (en) * 2004-01-13 2005-07-14 U.S. Genomics, Inc. Detection and quantification of analytes in solution using polymers
WO2005105830A1 (en) 2004-05-05 2005-11-10 Valorisation-Recherche, Societe En Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
US20060014680A1 (en) * 2004-07-13 2006-01-19 Caiding Xu Peptides and compounds that bind to the IL-5 receptor
US20060099662A1 (en) * 2004-04-16 2006-05-11 Genentech, Inc. Assay for antibodies
US20060182716A1 (en) * 2004-08-09 2006-08-17 Jin Hong Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US7105333B2 (en) 2001-03-27 2006-09-12 Deadreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
US20060204473A1 (en) * 2004-08-09 2006-09-14 Blatt Lawrence M Synthetic hyperglycosylated, and hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same
US7109299B1 (en) 1999-12-16 2006-09-19 Affymax, Inc. Peptides and compounds that bind to the IL-5 receptor
US7112430B2 (en) 2001-05-14 2006-09-26 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
US7125703B2 (en) 2001-03-13 2006-10-24 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
US7172892B2 (en) 2001-03-22 2007-02-06 Dendreon Corporation Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon
EP1798287A2 (de) 1997-08-01 2007-06-20 Schering Corporation Membranproteine aus Säugetierzellen und verwandte Reagentien
US20080031816A1 (en) * 2006-08-03 2008-02-07 Charles Keller Methods and compositions for identifying biomarkers
EP1897949A2 (de) 1998-09-21 2008-03-12 Schering Corporation Therapeutische Verwendungen von humanem Interleukin-B50
EP1908837A2 (de) 2000-05-25 2008-04-09 Schering Corporation Menschliche Rezeptorproteine, zugehörige Reagenzien und Verfahren
EP1916256A2 (de) 2001-09-25 2008-04-30 JAPAN as represented by PRESIDENT OF NATIONAL CANCER CENTER Such nach Krebsmarkern durch ein neues Screening-Verfahren
EP1918377A1 (de) 2000-05-10 2008-05-07 Schering Corporation Säuger-Rezeptorenproteine, zugehörige Reagenzien und Verfahren
US20080171344A1 (en) * 2006-12-22 2008-07-17 Kapsner Kenneth P Methods, Kits and Materials for Diagnosing Disease States by Measuring Isoforms or Proforms of Myeloperoxidase
EP1947183A1 (de) 1996-08-16 2008-07-23 Schering Corporation Säugerzelloberflächenantigene und damit zusammenhängende Reagenzien
EP1961760A2 (de) 1995-06-07 2008-08-27 Glaxo Group Limited Peptide und Verbindungen, die einen Thrombopoietin-Rezeptor binden
EP1967203A1 (de) 1998-07-15 2008-09-10 The Brigham and Women's Hospital Polysaccharid-Impfstoff gegen Infektionen durch Staphylokokken
EP1980573A2 (de) 1997-07-09 2008-10-15 Schering Corporation Isolierte dendritische Zellmembranproteingene
EP1983001A2 (de) 1998-09-25 2008-10-22 Schering Corporation Antikörper gegen Langerhans-Säugerzellantigene und ihr Einsatz
EP1988166A1 (de) 1997-05-07 2008-11-05 Schering Corporation Menschliche Toll-Like-Rezeptorproteine, zugehörige Reagenzien und Verfahren
EP1995317A1 (de) 1996-12-13 2008-11-26 Schering Corporation Säugerzelloberflächenantigene und damit zusammenhängende Reagenzien
WO2008150525A1 (en) 2007-06-04 2008-12-11 Genentech, Inc. Anti-notch1 nrr antibodies and methods using same
EP2028191A1 (de) 1996-12-11 2009-02-25 Glaxo Group Limited Peptide und Verbindungen, die einen Rezeptor binden
US20090080600A1 (en) * 2006-01-26 2009-03-26 Charles Keller Process and apparatus for imaging
EP2065467A2 (de) 2001-02-22 2009-06-03 Genentech, Inc. Anti-Interferon-alpha-Antikörper
EP2100959A2 (de) 1997-07-25 2009-09-16 Schering Corporation Säugetierzytokin: Interleukin-B30 und zugehörige Reagenzien
EP2138510A1 (de) 1999-07-30 2009-12-30 Schering Corporation Methoden der Erzeugung von gegen Zytokine gerichteten Antikörpern
US20100015654A1 (en) * 2005-05-16 2010-01-21 Institut De Recherches Cliniques De Montreal/ I.R.C.M. Negative regulation of NK cell functions by EAT-2, a sap-related adaptor expressed in innate immune cells
US20100035247A1 (en) * 2005-11-04 2010-02-11 U.S. Genomics, Inc. Heterogeneous Assay of Analytes in Solution Using Polymers
EP2256203A1 (de) 2003-11-21 2010-12-01 Schering Corporation Il-23 und dessen rezeptor, damit verbundene reagentien und verfahren
EP2292760A2 (de) 2000-11-10 2011-03-09 Schering Corporation Säuger Zytokine, Receptoren, verwandte Reagentien und Methoden
WO2011057120A1 (en) 2009-11-05 2011-05-12 Genentech, Inc. Methods and composition for secretion of heterologous polypeptides
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
EP2336321A1 (de) 1999-05-13 2011-06-22 Medical Research Council Ox2 Rezeptor Homolog
WO2011079185A1 (en) 2009-12-23 2011-06-30 Genentech, Inc. Anti-bv8 antibodies and uses thereof
EP2341144A1 (de) 1999-01-11 2011-07-06 Schering Corporation Interleukin-17-verbundene Säugetier-Cytokine.
US20110183363A1 (en) * 2009-10-26 2011-07-28 Saloumeh Fischer Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis
EP2364994A1 (de) 1994-01-05 2011-09-14 Schering Corporation Gereinigte Primaten CLTA-8 Antigene und verwandte Reagenzien
EP2366786A2 (de) 2005-05-05 2011-09-21 VALORISATION HSJ, Société en Commandite Zytokin-Rezeptormodulatoren und Verwendung davon
EP2402373A2 (de) 2006-01-05 2012-01-04 Genentech, Inc. ANTI-EPHB4-Antikörper sowie Verfahren zu deren Verwendung
WO2012030738A2 (en) 2010-08-30 2012-03-08 Beckman Coulter, Inc. Complex phosphoprotein activation profiles
EP2457929A1 (de) 2006-10-04 2012-05-30 Genentech, Inc. ELISA für VEGF
EP2468772A2 (de) 2006-03-16 2012-06-27 Genentech, Inc. EGFL7-Antikörper und Verwendungsverfahren
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
WO2012149320A1 (en) 2011-04-29 2012-11-01 Bristol-Myers Squibb Company Ip-10 antibody dosage escalation regimens
WO2013112912A1 (en) 2012-01-26 2013-08-01 Soares Christopher J Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use
WO2013142796A2 (en) 2012-03-23 2013-09-26 Bristol-Myers Squibb Company Methods of treatments using ctla4 antibodies
WO2013148373A1 (en) 2012-03-28 2013-10-03 Genentech, Inc. Anti-hcmv idiotypic antibodies and uses thereof
WO2013181348A1 (en) 2012-05-30 2013-12-05 The Brigham And Women's Hospital, Inc. Polysaccharide compositions and methods of use
WO2014036495A2 (en) 2012-08-31 2014-03-06 Immunogen Inc. Diagnostic assays and kits for detection of folate receptor 1
WO2015038884A2 (en) 2013-09-13 2015-03-19 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
EP2851372A1 (de) 2007-11-30 2015-03-25 Genentech, Inc. Anti-VEGF-Antikörper
WO2015057402A1 (en) 2013-10-18 2015-04-23 University Health Network Proteasome inhibition assay and methods of use
WO2015139046A1 (en) 2014-03-14 2015-09-17 Genentech, Inc. Methods and compositions for secretion of heterologous polypeptides
EP2942357A1 (de) 2008-08-04 2015-11-11 Glen N. Barber Sting (stimulator von interferongenen) als regulator angeborener immunreaktionen
WO2016069912A1 (en) 2014-10-29 2016-05-06 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules in vitro and in vivo
WO2016069906A1 (en) 2014-10-29 2016-05-06 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
WO2016144824A1 (en) 2015-03-06 2016-09-15 Genentech, Inc. Ultrapurified dsba and dsbc and methods of making and using the same
US20160313698A1 (en) * 2015-04-22 2016-10-27 Seiko Epson Corporation Timepiece and method for manufacturing timepiece
WO2017040342A1 (en) 2015-08-28 2017-03-09 Genentech, Inc. Anti-hypusine antibodies and uses thereof
WO2017106527A1 (en) 2015-12-15 2017-06-22 Case Western Reserve University Epithelial cancer evaluation using beta defensin
WO2017178526A1 (en) 2016-04-14 2017-10-19 Lonza Ltd Compositions and methods for the detection of host cell proteins
US9920120B2 (en) 2013-09-13 2018-03-20 Genentech, Inc. Methods and compositions comprising purified recombinant polypeptides
WO2018136553A1 (en) 2017-01-18 2018-07-26 Genentech, Inc. Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof
EP3418740A1 (de) 2012-11-07 2018-12-26 Phoenix Tissue Repair, Inc. Kollagen-iv-bindungstest für den nachweis von kollagen vii
EP3418299A1 (de) 2007-09-14 2018-12-26 Amgen Inc. Homogene antikörperpopulationen
US10281878B2 (en) * 2016-10-28 2019-05-07 Rolex Sa Watch mechanism
US10526418B2 (en) 2012-02-16 2020-01-07 The Penn State Research Foundation Modulators of ACYL-COA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
US20210063966A1 (en) * 2019-08-26 2021-03-04 Blancpain Sa Disengagement of two gear trains
US11141423B2 (en) 2010-01-25 2021-10-12 Icahn School Of Medicine At Mount Sinai Methods of screening compounds useful for treatment of a liver disease
WO2021222333A1 (en) 2020-04-30 2021-11-04 Genentech, Inc. Kras specific antibodies and uses thereof
EP3925980A1 (de) 2013-08-30 2021-12-22 ImmunoGen, Inc. Antikörper und tests zum nachweis von folatrezeptor 1
WO2022081436A1 (en) 2020-10-15 2022-04-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods
WO2022087274A1 (en) 2020-10-21 2022-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies that neutralize type-i interferon (ifn) activity
WO2022178255A2 (en) 2021-02-19 2022-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies that neutralize sars-cov-2
US11429066B2 (en) * 2018-06-19 2022-08-30 Sociéte anonyme de la manufacture d'horlogerie Audemars Piquet & Cie Instantaneous control device for a date display of a timepiece
US11435696B2 (en) * 2017-07-25 2022-09-06 Blancpain Sa Torque smoothing for a timepiece, particularly with a striking mechanism
US11550267B2 (en) 2017-03-22 2023-01-10 Manufacture D'horlogerie Audemars Piguet Sa Device for adjusting the functions of a timepiece

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3667435B1 (de) * 2018-12-10 2022-06-01 Montres Breguet S.A. Einstellsystem der position eines ersten gezahnten drehteils in bezug auf eine halterung, auf der dieser ersten gezahnten drehteil drehbar befestigt ist, und uhr, die ein solches system umfasst

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470688A (en) * 1967-07-26 1969-10-07 Suwa Seikosha Kk Date and day correcting device of a calendar timepiece
US3470687A (en) * 1966-12-15 1969-10-07 Suwa Seikosha Kk Date and day correcting device of a calendar timepiece

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH323982A (fr) * 1955-07-23 1957-08-31 Rolex Montres Pièce d'horlogerie à calendrier
CH394959A (fr) * 1963-03-08 1965-03-15 Tavannes Watch Co Sa Montre à remontage automatique, comprenant un dispositif manuel de mise à l'heure et de remontage et un quantième
DE1242512B (de) * 1964-08-25 1967-06-15 United States Time Corp Anzeigevorrichtung an einer Uhr zum Anzeigen einer Vielzahl von Kalenderinformationen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470687A (en) * 1966-12-15 1969-10-07 Suwa Seikosha Kk Date and day correcting device of a calendar timepiece
US3470688A (en) * 1967-07-26 1969-10-07 Suwa Seikosha Kk Date and day correcting device of a calendar timepiece

Cited By (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732687A (en) * 1971-02-17 1973-05-15 Citizen Watch Co Ltd Calendar correction mechanism for timepiece
US3775965A (en) * 1971-05-05 1973-12-04 Ebauches Sa Calendar timepiece
US3779000A (en) * 1971-10-06 1973-12-18 Suisse Horlogerie Correction device for day-and-date calendar watches
US3748848A (en) * 1971-10-29 1973-07-31 Ebauches Sa Day-date timepiece
US3969888A (en) * 1972-12-11 1976-07-20 Cyril Veuilleumier Driving mechanism for day-date calendar device
DE2824917A1 (de) 1977-07-13 1979-02-01 Corning Glass Works Biologisch aktive konjugate
WO1982000058A1 (en) * 1980-06-20 1982-01-07 Porter P Processes and apparatus for carrying out specific binding assays
US4443112A (en) * 1982-09-29 1984-04-17 Timex Corporation Planetary gear for date mechanism in a wristwatch
EP0253464A1 (de) 1986-03-21 1988-01-20 Hybritech Incorporated Verfahren für die Beschaffung interner Referenzen zur Verwendung in Analyt-Rezeptor-Tests
EP2364994A1 (de) 1994-01-05 2011-09-14 Schering Corporation Gereinigte Primaten CLTA-8 Antigene und verwandte Reagenzien
EP2338897A1 (de) 1995-06-07 2011-06-29 Glaxo Group Limited Peptide und Verbindungen, die einen Thrombopoietin-Rezeptor binden
EP1961760A2 (de) 1995-06-07 2008-08-27 Glaxo Group Limited Peptide und Verbindungen, die einen Thrombopoietin-Rezeptor binden
EP1947183A1 (de) 1996-08-16 2008-07-23 Schering Corporation Säugerzelloberflächenantigene und damit zusammenhängende Reagenzien
EP2336165A1 (de) 1996-12-11 2011-06-22 Glaxo Group Limited Peptide und Verbindungen, die einen Rezeptor binden
EP2028191A1 (de) 1996-12-11 2009-02-25 Glaxo Group Limited Peptide und Verbindungen, die einen Rezeptor binden
EP1995318A1 (de) 1996-12-13 2008-11-26 Schering Corporation Säugerzelloberflächenantigene und damit zusammenhängende Reagenzien
EP1995317A1 (de) 1996-12-13 2008-11-26 Schering Corporation Säugerzelloberflächenantigene und damit zusammenhängende Reagenzien
EP1988166A1 (de) 1997-05-07 2008-11-05 Schering Corporation Menschliche Toll-Like-Rezeptorproteine, zugehörige Reagenzien und Verfahren
EP1980573A2 (de) 1997-07-09 2008-10-15 Schering Corporation Isolierte dendritische Zellmembranproteingene
EP2100959A2 (de) 1997-07-25 2009-09-16 Schering Corporation Säugetierzytokin: Interleukin-B30 und zugehörige Reagenzien
EP2233574A1 (de) 1997-07-25 2010-09-29 Schering Corporation Säugetierzytokin: Interleukin-B30 und zugehörige Reagenzien
EP1798286A2 (de) 1997-08-01 2007-06-20 Schering Corporation Membranproteine aus Säugetierzellen und verwandte Reagentien
EP1798287A2 (de) 1997-08-01 2007-06-20 Schering Corporation Membranproteine aus Säugetierzellen und verwandte Reagentien
EP1967203A1 (de) 1998-07-15 2008-09-10 The Brigham and Women's Hospital Polysaccharid-Impfstoff gegen Infektionen durch Staphylokokken
EP2314696A1 (de) 1998-09-21 2011-04-27 Schering Corporation Therapeutische Verwendungen von humanem Interleukin-B50 Antagonist.
EP1897949A2 (de) 1998-09-21 2008-03-12 Schering Corporation Therapeutische Verwendungen von humanem Interleukin-B50
EP1983001A2 (de) 1998-09-25 2008-10-22 Schering Corporation Antikörper gegen Langerhans-Säugerzellantigene und ihr Einsatz
EP2341144A1 (de) 1999-01-11 2011-07-06 Schering Corporation Interleukin-17-verbundene Säugetier-Cytokine.
EP2341143A1 (de) 1999-05-13 2011-07-06 Medical Research Council OX2 Rezeptor Homolog
EP2336321A1 (de) 1999-05-13 2011-06-22 Medical Research Council Ox2 Rezeptor Homolog
WO2000073451A1 (en) 1999-06-01 2000-12-07 Schering Corporation Mammalian receptor proteins; related reagents and methods
EP2258849A1 (de) 1999-06-01 2010-12-08 Schering Corporation Säugetier-Rezeptorproteine; ähnliche Reagentien und Methoden
EP1950299A1 (de) 1999-06-01 2008-07-30 Schering Corporation Säuger-Rezeptorproteine, zugehörige Reagenzien und Verfahren
US20030170859A1 (en) * 1999-06-16 2003-09-11 Erik Christenson Human poly (ADP-ribose) polymerase 2 materials and methods
US6989260B2 (en) 1999-06-16 2006-01-24 Icos Corporation Human poly(ADP-ribose) polymerase 2 materials and methods
US6599727B1 (en) 1999-06-16 2003-07-29 Icos Corporation Human poly (ADP-ribose) polymerase 2 materials and methods
EP2138510A1 (de) 1999-07-30 2009-12-30 Schering Corporation Methoden der Erzeugung von gegen Zytokine gerichteten Antikörpern
US20030180749A1 (en) * 1999-10-13 2003-09-25 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
US7668658B2 (en) 1999-10-13 2010-02-23 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
US8818735B2 (en) 1999-10-13 2014-08-26 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
US8229677B2 (en) 1999-10-13 2012-07-24 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
US20100292930A1 (en) * 1999-10-13 2010-11-18 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
US7109299B1 (en) 1999-12-16 2006-09-19 Affymax, Inc. Peptides and compounds that bind to the IL-5 receptor
US7482433B2 (en) 1999-12-16 2009-01-27 Affymax, Inc. Peptides and compounds that bind to the IL-5 receptor
EP2275548A1 (de) 2000-05-10 2011-01-19 Schering Corporation Zytokinrezeptoruntereinheit-Proteine aus Säugetieren, damit zusammenhängende Reagenzien und Methoden
EP1918377A1 (de) 2000-05-10 2008-05-07 Schering Corporation Säuger-Rezeptorenproteine, zugehörige Reagenzien und Verfahren
EP1908837A2 (de) 2000-05-25 2008-04-09 Schering Corporation Menschliche Rezeptorproteine, zugehörige Reagenzien und Verfahren
WO2002020569A2 (en) 2000-09-08 2002-03-14 Schering Corporation Mammalian genes; related reagents and methods
EP2298789A1 (de) 2000-09-08 2011-03-23 Schering Corporation Gene von Säugetiere, und damit verbundene Reagentien, Methoden
EP2292760A2 (de) 2000-11-10 2011-03-09 Schering Corporation Säuger Zytokine, Receptoren, verwandte Reagentien und Methoden
EP2292301A2 (de) 2001-02-22 2011-03-09 Genentech, Inc. Anti-Interferon-alpha-Antikörper
EP2065467A2 (de) 2001-02-22 2009-06-03 Genentech, Inc. Anti-Interferon-alpha-Antikörper
US7125703B2 (en) 2001-03-13 2006-10-24 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
US7172892B2 (en) 2001-03-22 2007-02-06 Dendreon Corporation Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon
US7105333B2 (en) 2001-03-27 2006-09-12 Deadreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
US7112430B2 (en) 2001-05-14 2006-09-26 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
EP1916256A2 (de) 2001-09-25 2008-04-30 JAPAN as represented by PRESIDENT OF NATIONAL CANCER CENTER Such nach Krebsmarkern durch ein neues Screening-Verfahren
EP2072059A1 (de) 2001-10-12 2009-06-24 Schering Corporation Verwendung von bispezifischen Antikörpern zur Regulierung der Immunreaktion
WO2003030835A2 (en) 2001-10-12 2003-04-17 Schering Corporation Use of bispecific antibodies to regulate immune responses
EP2316485A1 (de) 2001-10-12 2011-05-04 Schering Corporation Verwendung von bispezifischen Antikörpern zur Regulierung der Immunreaktion
US20030134794A1 (en) * 2001-11-20 2003-07-17 Madison Edwin L. Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon
US20030232420A1 (en) * 2002-05-03 2003-12-18 Andreas Braun Kinase anchor protein muteins, peptides thereof and related documents
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
US20090155846A1 (en) * 2002-05-03 2009-06-18 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related methods
US20040001801A1 (en) * 2002-05-23 2004-01-01 Corvas International, Inc. Conjugates activated by cell surface proteases and therapeutic uses thereof
US7575893B2 (en) 2003-01-23 2009-08-18 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
US20080187966A1 (en) * 2003-01-23 2008-08-07 Genentech, Inc. Antibodies and methods for making and using them
US20040229310A1 (en) * 2003-01-23 2004-11-18 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
EP2256203A1 (de) 2003-11-21 2010-12-01 Schering Corporation Il-23 und dessen rezeptor, damit verbundene reagentien und verfahren
US20050153354A1 (en) * 2004-01-13 2005-07-14 U.S. Genomics, Inc. Detection and quantification of analytes in solution using polymers
US7977048B2 (en) 2004-01-13 2011-07-12 Pathogenetix, Inc. Detection and quantification of analytes in solution using polymers
US20080176257A9 (en) * 2004-04-16 2008-07-24 Genentech, Inc. Assay for Antibodies
US20070015228A1 (en) * 2004-04-16 2007-01-18 Genentech, Inc. Assay for Antibodies
US20060099662A1 (en) * 2004-04-16 2006-05-11 Genentech, Inc. Assay for antibodies
WO2005105830A1 (en) 2004-05-05 2005-11-10 Valorisation-Recherche, Societe En Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
US20060014680A1 (en) * 2004-07-13 2006-01-19 Caiding Xu Peptides and compounds that bind to the IL-5 receptor
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US20100099851A1 (en) * 2004-08-09 2010-04-22 Alios Biopharma, Inc. Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US20060182716A1 (en) * 2004-08-09 2006-08-17 Jin Hong Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US20060204473A1 (en) * 2004-08-09 2006-09-14 Blatt Lawrence M Synthetic hyperglycosylated, and hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same
EP2366786A2 (de) 2005-05-05 2011-09-21 VALORISATION HSJ, Société en Commandite Zytokin-Rezeptormodulatoren und Verwendung davon
US20100015654A1 (en) * 2005-05-16 2010-01-21 Institut De Recherches Cliniques De Montreal/ I.R.C.M. Negative regulation of NK cell functions by EAT-2, a sap-related adaptor expressed in innate immune cells
US20100035247A1 (en) * 2005-11-04 2010-02-11 U.S. Genomics, Inc. Heterogeneous Assay of Analytes in Solution Using Polymers
EP2402373A2 (de) 2006-01-05 2012-01-04 Genentech, Inc. ANTI-EPHB4-Antikörper sowie Verfahren zu deren Verwendung
EP3156418A1 (de) 2006-01-05 2017-04-19 Genentech, Inc. Anti-ephb4-antikörper sowie verfahren zu deren verwendung
US20090080600A1 (en) * 2006-01-26 2009-03-26 Charles Keller Process and apparatus for imaging
US8189737B2 (en) 2006-01-26 2012-05-29 The Board Of Regents, The University Of Texas System, A Texas Institution Of Higher Learning Process and apparatus for microCT imaging of ex vivo specimens
US8553836B2 (en) 2006-01-26 2013-10-08 The Board Of Regents, The University Of Texas System Process for producing a microCT image of a stained specimen
EP2093235A1 (de) 2006-02-08 2009-08-26 Alios Biopharma Inc. Hyperglycosylierte Varianten des Interferons alfacon-1
EP2468772A2 (de) 2006-03-16 2012-06-27 Genentech, Inc. EGFL7-Antikörper und Verwendungsverfahren
US20080031816A1 (en) * 2006-08-03 2008-02-07 Charles Keller Methods and compositions for identifying biomarkers
EP3103812A1 (de) 2006-10-04 2016-12-14 Genentech, Inc. Elisa für vegf
EP2457929A1 (de) 2006-10-04 2012-05-30 Genentech, Inc. ELISA für VEGF
US20080171344A1 (en) * 2006-12-22 2008-07-17 Kapsner Kenneth P Methods, Kits and Materials for Diagnosing Disease States by Measuring Isoforms or Proforms of Myeloperoxidase
WO2008150525A1 (en) 2007-06-04 2008-12-11 Genentech, Inc. Anti-notch1 nrr antibodies and methods using same
EP3418299A1 (de) 2007-09-14 2018-12-26 Amgen Inc. Homogene antikörperpopulationen
EP3173425A1 (de) 2007-11-30 2017-05-31 Genentech, Inc. Anti-vegf-antikörper
EP2851372A1 (de) 2007-11-30 2015-03-25 Genentech, Inc. Anti-VEGF-Antikörper
EP2942357A1 (de) 2008-08-04 2015-11-11 Glen N. Barber Sting (stimulator von interferongenen) als regulator angeborener immunreaktionen
US20110183363A1 (en) * 2009-10-26 2011-07-28 Saloumeh Fischer Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis
US9315583B2 (en) 2009-10-26 2016-04-19 Genentech, Inc. Assays for detecting antibodies specific to therapeutic anti-IgE antibodies and their use in anaphylaxis
WO2011057120A1 (en) 2009-11-05 2011-05-12 Genentech, Inc. Methods and composition for secretion of heterologous polypeptides
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
WO2011079185A1 (en) 2009-12-23 2011-06-30 Genentech, Inc. Anti-bv8 antibodies and uses thereof
US11141423B2 (en) 2010-01-25 2021-10-12 Icahn School Of Medicine At Mount Sinai Methods of screening compounds useful for treatment of a liver disease
WO2012030738A2 (en) 2010-08-30 2012-03-08 Beckman Coulter, Inc. Complex phosphoprotein activation profiles
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
WO2012149320A1 (en) 2011-04-29 2012-11-01 Bristol-Myers Squibb Company Ip-10 antibody dosage escalation regimens
WO2013112912A1 (en) 2012-01-26 2013-08-01 Soares Christopher J Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use
US10526418B2 (en) 2012-02-16 2020-01-07 The Penn State Research Foundation Modulators of ACYL-COA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
WO2013142796A2 (en) 2012-03-23 2013-09-26 Bristol-Myers Squibb Company Methods of treatments using ctla4 antibodies
WO2013148373A1 (en) 2012-03-28 2013-10-03 Genentech, Inc. Anti-hcmv idiotypic antibodies and uses thereof
US9139659B2 (en) * 2012-03-28 2015-09-22 Genentech, Inc. Idiotypic antibodies and uses thereof
US20130266973A1 (en) * 2012-03-28 2013-10-10 Genentech, Inc. Idiotypic antibodies and uses thereof
WO2013181348A1 (en) 2012-05-30 2013-12-05 The Brigham And Women's Hospital, Inc. Polysaccharide compositions and methods of use
EP3712175A1 (de) 2012-08-31 2020-09-23 ImmunoGen, Inc. Diagnostische tests und kits zum nachweis von folatrezeptor 1
WO2014036495A2 (en) 2012-08-31 2014-03-06 Immunogen Inc. Diagnostic assays and kits for detection of folate receptor 1
EP3418740A1 (de) 2012-11-07 2018-12-26 Phoenix Tissue Repair, Inc. Kollagen-iv-bindungstest für den nachweis von kollagen vii
EP3925980A1 (de) 2013-08-30 2021-12-22 ImmunoGen, Inc. Antikörper und tests zum nachweis von folatrezeptor 1
EP4163633A1 (de) 2013-09-13 2023-04-12 F. Hoffmann-La Roche AG Zusammensetzungen und verfahren zur erkennung und quantifizierung von wirtszellenprotein in zelllinien und rekombinante polypeptidprodukte
US9945858B2 (en) 2013-09-13 2018-04-17 Genentech, Inc. Compositions and methods for detecting and quantifying host cells protein in cell lines and recombinant polypeptide products
US11667706B2 (en) 2013-09-13 2023-06-06 Genentech, Inc. Methods of purifying recombinant anti-abeta antibodies
US11519912B2 (en) 2013-09-13 2022-12-06 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
US10597447B2 (en) 2013-09-13 2020-03-24 Genentech, Inc. Compositions comprising purified recombinant IL-13 antibody
US10597446B2 (en) 2013-09-13 2020-03-24 Genentech, Inc. Method of treatment comprising purified recombinant IL-13 antibody
US9920120B2 (en) 2013-09-13 2018-03-20 Genentech, Inc. Methods and compositions comprising purified recombinant polypeptides
US10494429B2 (en) 2013-09-13 2019-12-03 Genentech, Inc. Compositions comprising purified anti-abeta monoclonal antibodies
US10788494B2 (en) 2013-09-13 2020-09-29 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
US10822404B2 (en) 2013-09-13 2020-11-03 Genentech, Inc. Methods and compositions comprising purified recombinant polypeptides
WO2015038884A2 (en) 2013-09-13 2015-03-19 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
WO2015057402A1 (en) 2013-10-18 2015-04-23 University Health Network Proteasome inhibition assay and methods of use
EP3360969A1 (de) 2013-10-18 2018-08-15 University Health Network Proteasomhemmtest und verfahren zur verwendung
WO2015139046A1 (en) 2014-03-14 2015-09-17 Genentech, Inc. Methods and compositions for secretion of heterologous polypeptides
WO2016069912A1 (en) 2014-10-29 2016-05-06 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules in vitro and in vivo
US11071790B2 (en) 2014-10-29 2021-07-27 Massachusetts Eye And Ear Infirmary Method for efficient delivery of therapeutic molecules in vitro and in vivo
US11370823B2 (en) 2014-10-29 2022-06-28 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
WO2016069906A1 (en) 2014-10-29 2016-05-06 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
WO2016069910A1 (en) 2014-10-29 2016-05-06 Massachusetts Eye And Ear Infirmary Methods for efficient delivery of therapeutic molecules in vitro and in vivo
WO2016144824A1 (en) 2015-03-06 2016-09-15 Genentech, Inc. Ultrapurified dsba and dsbc and methods of making and using the same
US10690671B2 (en) 2015-03-06 2020-06-23 Genentech, Inc. Ultrapurified DsbA and DsbC and methods of making and using the same
EP3636749A1 (de) 2015-03-06 2020-04-15 F. Hoffmann-La Roche AG Ultrareine dsba und dsbc und verfahren zur herstellung und verwendung davon
US10073098B2 (en) 2015-03-06 2018-09-11 Genentech, Inc. Ultrapurified DsbA and DsbC and methods of making and using the same
US20160313698A1 (en) * 2015-04-22 2016-10-27 Seiko Epson Corporation Timepiece and method for manufacturing timepiece
US9791832B2 (en) * 2015-04-22 2017-10-17 Seiko Epson Corporation Timepiece and method for manufacturing timepiece
WO2017040342A1 (en) 2015-08-28 2017-03-09 Genentech, Inc. Anti-hypusine antibodies and uses thereof
EP3932953A1 (de) 2015-08-28 2022-01-05 F. Hoffmann-La Roche AG Anti-hypusin-antikörper und verwendungen davon
WO2017106527A1 (en) 2015-12-15 2017-06-22 Case Western Reserve University Epithelial cancer evaluation using beta defensin
EP3683579A1 (de) 2016-04-14 2020-07-22 Lonza Ltd Zusammensetzungen und verfahren zur detektion von wirtszellenproteinen
WO2017178526A1 (en) 2016-04-14 2017-10-19 Lonza Ltd Compositions and methods for the detection of host cell proteins
US10281878B2 (en) * 2016-10-28 2019-05-07 Rolex Sa Watch mechanism
WO2018136553A1 (en) 2017-01-18 2018-07-26 Genentech, Inc. Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof
US11550267B2 (en) 2017-03-22 2023-01-10 Manufacture D'horlogerie Audemars Piguet Sa Device for adjusting the functions of a timepiece
US11435696B2 (en) * 2017-07-25 2022-09-06 Blancpain Sa Torque smoothing for a timepiece, particularly with a striking mechanism
US11429066B2 (en) * 2018-06-19 2022-08-30 Sociéte anonyme de la manufacture d'horlogerie Audemars Piquet & Cie Instantaneous control device for a date display of a timepiece
US20210063966A1 (en) * 2019-08-26 2021-03-04 Blancpain Sa Disengagement of two gear trains
US11733654B2 (en) * 2019-08-26 2023-08-22 Omega Sa Disengagement of two gear trains
WO2021222333A1 (en) 2020-04-30 2021-11-04 Genentech, Inc. Kras specific antibodies and uses thereof
WO2022081436A1 (en) 2020-10-15 2022-04-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods
WO2022087274A1 (en) 2020-10-21 2022-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies that neutralize type-i interferon (ifn) activity
WO2022178255A2 (en) 2021-02-19 2022-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies that neutralize sars-cov-2

Also Published As

Publication number Publication date
GB1319315A (en) 1973-06-06
FR2046920B1 (de) 1974-05-03
DE2031216A1 (de) 1971-01-14
FR2046920A1 (de) 1971-03-12

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