US3637072A - Device for preserving drugs for injection - Google Patents
Device for preserving drugs for injection Download PDFInfo
- Publication number
- US3637072A US3637072A US191A US3637072DA US3637072A US 3637072 A US3637072 A US 3637072A US 191 A US191 A US 191A US 3637072D A US3637072D A US 3637072DA US 3637072 A US3637072 A US 3637072A
- Authority
- US
- United States
- Prior art keywords
- casing
- drug
- container unit
- needle assembly
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
- A61M2005/3109—Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
Definitions
- This invention relates to a method of and device for preserving drugs, and more particularly to a method of and device for preserving inoculums, such as BCG, PPD etc., or other drugs for injection, such as SLO, in such a small quantity as to be used for a small number of persons such, for example, as several persons.
- inoculums for use in preventive inoculation are preserved in large containers, such as a large bottle, capable of containing such inoculums for a large number of persons, such for example, as 20 to 100 or more, for the purpose of making a collective inoculation.
- the disadvantage is that lots of the inoculum contained in the container, for example, more than a half of it will adhere to the interior face of the container and will become useless.
- the present invention is intended to eliminate such inconveniences and disadvantages indicated with conventional containers of this kind.
- FIGS. I through d are longitudinal cross-sectional views, in an enlarged scale, of embodiments of the present invention, respectively.
- the unit A comprises a relatively small vertically elongated cylindrical casing I with its upper end In opened which may be made ofa glass, a metal or a synthetic resin, a support member 2 made of a flexible and soft rubber or synthetic resin, a needle assembly S composed of a needle 3 and a cup member 4i fixed to the base 3a of the needle and intercommunicating with the nee dle, and a cap 5 for closing the opening of the casing I.
- the support member 2 is provided with a base portion 2a adapted to be snugly inserted in the casing l and to he placed on the bottom wall 1b, and with a protrusion 2b protruding upwardly from the upper face of the base portion 2a and adapted to be pricked by the sharpened tip 3b of needle 3.
- the cap 5 has a flat portion 5a having the diameter corresponding substantially to the outside diameter of the cylindrical casing ll and is provided with an inverted cup-shaped portion 5b depending from the flat portion 5a and arranged to be snugly inserted in the cup member 4! of needle assembly S.
- the depth or height of the casing l is designed so that when the cap 5 is placed on the upper end Ila of casing t after the needle 3 of the needle assembly S has been stuck into the support 2 at its tip portion, the cup-shaped portion 5b of the cap is brought into engagement with the upper portion of the inner peripheral face of cup member 4i of the needle assembly.
- the inoculum or drug for injection is put into the cup member 4.
- the inoculum or drug thus put into the cup member is prevented from flowing off through the needle 3, because the opening of the tip 3b is sealingly closed by the portion, surrounding the tip portion, of the elastic support 2 which is in pressure contact with said tip portion.
- the inoculum or drug in the cup member 4 is subjected to application of the process of freezedrying which is often applied to, for example, foods for preservation.
- the upper opening of easing l is sealed with the cap 5 airtight by interposing between the entire top face of casing I and the underside of the cap 5 a packing material 7 and by applying a pressure to said cap to press the same against the top face of said casing.
- the packing material which is suitable for use in the sealing is, for example, an atactic polypropylene, an atactic polyethylene, their mixed compounds, etc.
- the casing I is sealed under a reduced atmospheric pressure.
- the cap 5 When it is desired to sue the container unit A for inoculation or injection, first, the cap 5 is removed and the needle assembly S is drawn out and attached to the glass cylinder of a conventional syringe, not shown, and then a necessary liquid for dissolving the contents is fed into the cup member 4 through the needle 3 by manipulating the plunger of the syringe in conventional manner. With this operation, the preserved contents is easily dissolved and flows into the glass cylinder in a liquid state, thus enabling the injector to practice injection.
- the drugs to be preserved in accordance with the present invention may either be of liquid or powder or of any other form as long as they are for use in injection and are suited for the application of the process of freeze-drying.
- FIG. 2 there is shown a variant B of the drug preservation container unit A shown in FIG. I.
- the unit B is provided with a cuplike portion 20 having bore 2d and extending vertically upwardly from the protruding portion 2b of the support 2.
- the depth of the bore 20. is made slightly shorter than the length of the needle 3 so that when the needle 3 is stuck at its tip into the protruding portion 2b, the cup member 4 of the needle assembly S is brought into contact at its bottom portion with the top surface of the cuplike portion 20, thereby enabling the needle assembly S to be securely supported by the support member 2.
- FIG. 2 is the same as the embodiment previously described. in construction, with the exception of the provision of the cuplike portion 2c.
- the manner of assembling the unit and the method of preserving drugs in this instance are also the same as those in the first em bodiment and further description as to these and other matters will be omitted.
- the: casing IA is made of a metal, such as aluminum and is provided at its upper portion adjacent the upper end lAa with a contracted portion llAc defining the upper opening of the casing.
- the support 2A inserted in the casing IA is composed of an open-ended cylinder ZAc of plastics, such as polyethylene, and a pad member 2Aa of flexible and soft rubber or plastics into which the tip portion of the needle 3 is stuck.
- the support 2A is placed on the bottom lAb of casing 1A in an upright positioned as shown.
- the cup member 4A of the needle assembly S vertically supported by the support 2A within casing 1A is covered with a packing 8 of plastics, such as an urethane foam, inserted in the upper opening of easing 1A.
- a packing 8 of plastics such as an urethane foam
- the casing 1A is sealed with a flat cap 5A with the intermediary of the packing material 7 previously described.
- the casing 1A is sealed under a reduced atmospheric pressure.
- cap 5A After the opening of easing 1A has been sealed with cap 5A, the head portion of casing 1A with cap 5A is covered with an aluminum foil 5A for the purpose of protection of the cap 5A.
- the casing 18 is made of a solid synthetic resin and is tapered inwardly upwardly at [B and terminates in the open end lBa.
- the casing 1B is also formed inside thereof with shoulder portions lBd for receiving the lower portion of cup member 48 of the needle assembly S.
- a support member 2B is inserted in the casing 18 and placed on the bottom lBb of casing 18.
- the cap 58 is provided with a cylindrical skirt B0 depending from the top portion 58a and having the same diameter as the casing 1B, and also with a inverted cuplike portion 58b, and is arranged to be snugly mounted on the tapered portion 18C of the casing 1B.
- the casing 18 is sealed with the cap 53 under a normal atmospheric pressure.
- the casing 13 covered with the cap 58 is sealed in an aluminum foil wrapper 9, as shown in FIG. 4, to prevent moisture.
- the casing 1B is preferably filled with nitrogen gas.
- the drug for use in inoculation or injection is preserved in the cup member of the needle assembly and, for example, when several persons are inoculated with the preserved substance, the inoculation for at least the first person can be made by the needle without using other needle.
- the tip of the needle is protected by the flexible support by being kept stuck into therein, so that the tip of the needle can be kept free from damage.
- a drug preservation container unit for use in connection with injection comprising a relatively small vertically elongated casing with its upper end opened, a support of flexible and soft rubber mounted within said casing, a needle assembly composed of a needle and a cup member fixed to the base thereof and connectable to the cylinder of a syringe, said needle assembly being held in an upright position within said casing, the needle of said needle assembly being stuck into said support at its tip portion, a predetermined amount of drug for use in injection, said drug being contained in said cup member and subjected to the process of freeze-drying for preservation and a cap sealing the upper opening of said casing and of said cup.
- a drug preservation container unit as set forth in claim I wherein said cap is provided with an inverted cuplike portion depending therefrom and arranged to cover the opening of the cup member of said needle assembly.
- said support is composed of a pad and an open-ended cylinder in which said pad is inserted, said pad being of flexible and soft rubber and arranged to allow the tip portion of said needle to stick thereinto, said open-ended cylinder being arranged to receive at its upper end the cup member of said needle assembly.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Vacuum Packaging (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP44001840A JPS5011713B1 (fr) | 1969-01-09 | 1969-01-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3637072A true US3637072A (en) | 1972-01-25 |
Family
ID=11512734
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US191A Expired - Lifetime US3637072A (en) | 1969-01-09 | 1970-01-02 | Device for preserving drugs for injection |
US152529A Expired - Lifetime US3696579A (en) | 1969-01-09 | 1971-06-14 | Method of and device for preserving drugs for injection |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US152529A Expired - Lifetime US3696579A (en) | 1969-01-09 | 1971-06-14 | Method of and device for preserving drugs for injection |
Country Status (7)
Country | Link |
---|---|
US (2) | US3637072A (fr) |
JP (1) | JPS5011713B1 (fr) |
CH (1) | CH521129A (fr) |
DE (1) | DE2000772C3 (fr) |
DK (1) | DK121462B (fr) |
FR (1) | FR2027995A1 (fr) |
GB (1) | GB1261779A (fr) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3868015A (en) * | 1973-09-14 | 1975-02-25 | Larry G Thompson | Insect bite kit |
US4446967A (en) * | 1982-05-07 | 1984-05-08 | Halkyard Douglas R | Germicide sleeve for dental and medical instruments |
US4735311A (en) * | 1986-04-09 | 1988-04-05 | The West Company | Needle shield assembly |
US4848569A (en) * | 1988-09-20 | 1989-07-18 | Leishman Layne S | Apparatus and method for disposing of contaminated needles |
US5085647A (en) * | 1991-03-07 | 1992-02-04 | Sherwood Medical Company | Rigid needle cover with needle sealing plug and method of manufacture thereof |
US5152394A (en) * | 1991-09-10 | 1992-10-06 | Mcdonald, Withers & Hughes, Inc. | Personal use syringe dispensing and collecting system |
US5161681A (en) * | 1989-04-24 | 1992-11-10 | Kemp David R | Safety container for hypodermic syringes |
US5167193A (en) * | 1991-05-14 | 1992-12-01 | Mcdonald, Withers & Hughes, Inc. | Medical wastes disposal system |
US5172808A (en) * | 1988-07-01 | 1992-12-22 | John Bruno | Device for safely transporting one or more hypodermic needles or the like from point of use to point of ultimate disposal |
US5230428A (en) * | 1990-06-15 | 1993-07-27 | Mcshane Jerry M | Apparatus for the disposal of contaminated needles |
US5259501A (en) * | 1991-09-10 | 1993-11-09 | Mcdonald, Withers & Hughes, Inc. | Personal use syringe collecting and disposing system |
US5385105A (en) * | 1991-05-14 | 1995-01-31 | Mcdonald, Withers & Hughes, Inc. | Burnable wastes collector with liquid absorber and identifier |
US5431280A (en) * | 1994-03-17 | 1995-07-11 | Humagen Fertility Diagnostics Inc. | Closure cap for holding pipets during shipping |
US5458072A (en) * | 1991-05-14 | 1995-10-17 | Hughes; David W. | Disposable medical wastes collector with liquid absorber |
US5483973A (en) * | 1992-10-30 | 1996-01-16 | Becton, Dickinson And Company | Needle stopper and needle removal device |
US6503230B2 (en) | 1998-07-31 | 2003-01-07 | Robert B. Odell | Needle shield for a prefillable syringe |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4018222A (en) * | 1975-02-10 | 1977-04-19 | Merck & Co., Inc. | Syringe containing frozen vaccine |
JPS54149415U (fr) * | 1978-04-10 | 1979-10-17 | ||
JPS54154109U (fr) * | 1978-04-17 | 1979-10-26 | ||
JPS5513915U (fr) * | 1978-07-05 | 1980-01-29 | ||
FR2583979B1 (fr) * | 1985-07-01 | 1987-08-21 | Merieux Inst | Procede de preparation en serie de seringues auto-injectables en conteneur etanche, pour medicament lyophilise, et dispositif pour mettre en oeuvre ce procede |
FR2791254B1 (fr) | 1999-03-25 | 2001-06-08 | Pierre Frezza | Ampoule pour le conditionnement d'un liquide a usage medical |
US6434913B1 (en) * | 2000-09-15 | 2002-08-20 | Thomas Hatch | Single-use syringe |
DE102008030267B3 (de) | 2008-06-19 | 2010-01-28 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Verfahren zum Befüllen von Doppelkammersystemen in vorsterilisierbaren Trägersystemen und vorsterilisierbares Trägersystem |
DE102008030268B3 (de) * | 2008-06-19 | 2010-02-04 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Verfahren zum Befüllen von Doppelkammersystemen in vorsterilisierbaren Trägersystemen und vorsterilisierbares Trägersystem |
EP2750741A1 (fr) | 2011-08-30 | 2014-07-09 | Novo Nordisk A/S | Dispositif pour la distribution séquentielle de volumes de fluide |
EP3009354A1 (fr) * | 2014-10-15 | 2016-04-20 | F. Hoffmann-La Roche AG | Procédé permettant de fournir dans un récipient d'emballage primaire un produit solide séché contenant un ingrédient pharmaceutique actif |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2400722A (en) * | 1944-07-10 | 1946-05-21 | Harry L Swan | Hypodermic needle case |
US3107785A (en) * | 1960-10-04 | 1963-10-22 | Brunswick Corp | Syringe-container structure |
US3255873A (en) * | 1963-10-11 | 1966-06-14 | Propper Mfg Company Inc | Combination sealing and dispensing device |
US3337041A (en) * | 1965-10-23 | 1967-08-22 | Charles W Damaskus | Layered lyophilized product in a disposable syringe |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE306891C (fr) * | ||||
US2929510A (en) * | 1955-03-02 | 1960-03-22 | Wil Pen Company | Hypodermic needle holder |
NL296465A (fr) * | 1962-08-10 | |||
US3342180A (en) * | 1964-04-24 | 1967-09-19 | American Cyanamid Co | Disposable liquid-powder package and hypodermic syringe |
US3563373A (en) * | 1967-10-06 | 1971-02-16 | Paul E Paulson | Hypodermic syringe assembly |
-
1969
- 1969-01-09 JP JP44001840A patent/JPS5011713B1/ja active Pending
- 1969-12-31 GB GB63492/69A patent/GB1261779A/en not_active Expired
-
1970
- 1970-01-02 US US191A patent/US3637072A/en not_active Expired - Lifetime
- 1970-01-08 DK DK7670AA patent/DK121462B/da not_active IP Right Cessation
- 1970-01-08 FR FR7000593A patent/FR2027995A1/fr not_active Withdrawn
- 1970-01-09 DE DE2000772A patent/DE2000772C3/de not_active Expired
- 1970-01-09 CH CH28470A patent/CH521129A/de not_active IP Right Cessation
-
1971
- 1971-06-14 US US152529A patent/US3696579A/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2400722A (en) * | 1944-07-10 | 1946-05-21 | Harry L Swan | Hypodermic needle case |
US3107785A (en) * | 1960-10-04 | 1963-10-22 | Brunswick Corp | Syringe-container structure |
US3255873A (en) * | 1963-10-11 | 1966-06-14 | Propper Mfg Company Inc | Combination sealing and dispensing device |
US3337041A (en) * | 1965-10-23 | 1967-08-22 | Charles W Damaskus | Layered lyophilized product in a disposable syringe |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3868015A (en) * | 1973-09-14 | 1975-02-25 | Larry G Thompson | Insect bite kit |
US4446967A (en) * | 1982-05-07 | 1984-05-08 | Halkyard Douglas R | Germicide sleeve for dental and medical instruments |
US4735311A (en) * | 1986-04-09 | 1988-04-05 | The West Company | Needle shield assembly |
US5172808A (en) * | 1988-07-01 | 1992-12-22 | John Bruno | Device for safely transporting one or more hypodermic needles or the like from point of use to point of ultimate disposal |
US4848569A (en) * | 1988-09-20 | 1989-07-18 | Leishman Layne S | Apparatus and method for disposing of contaminated needles |
US5161681A (en) * | 1989-04-24 | 1992-11-10 | Kemp David R | Safety container for hypodermic syringes |
US5230428A (en) * | 1990-06-15 | 1993-07-27 | Mcshane Jerry M | Apparatus for the disposal of contaminated needles |
US5085647A (en) * | 1991-03-07 | 1992-02-04 | Sherwood Medical Company | Rigid needle cover with needle sealing plug and method of manufacture thereof |
US5167193A (en) * | 1991-05-14 | 1992-12-01 | Mcdonald, Withers & Hughes, Inc. | Medical wastes disposal system |
US5385105A (en) * | 1991-05-14 | 1995-01-31 | Mcdonald, Withers & Hughes, Inc. | Burnable wastes collector with liquid absorber and identifier |
US5458072A (en) * | 1991-05-14 | 1995-10-17 | Hughes; David W. | Disposable medical wastes collector with liquid absorber |
US5152394A (en) * | 1991-09-10 | 1992-10-06 | Mcdonald, Withers & Hughes, Inc. | Personal use syringe dispensing and collecting system |
US5259501A (en) * | 1991-09-10 | 1993-11-09 | Mcdonald, Withers & Hughes, Inc. | Personal use syringe collecting and disposing system |
US5483973A (en) * | 1992-10-30 | 1996-01-16 | Becton, Dickinson And Company | Needle stopper and needle removal device |
US5431280A (en) * | 1994-03-17 | 1995-07-11 | Humagen Fertility Diagnostics Inc. | Closure cap for holding pipets during shipping |
US6503230B2 (en) | 1998-07-31 | 2003-01-07 | Robert B. Odell | Needle shield for a prefillable syringe |
Also Published As
Publication number | Publication date |
---|---|
CH521129A (de) | 1972-04-15 |
DE2000772A1 (de) | 1970-09-03 |
GB1261779A (en) | 1972-01-26 |
FR2027995A1 (fr) | 1970-10-02 |
US3696579A (en) | 1972-10-10 |
JPS5011713B1 (fr) | 1975-05-06 |
DK121462B (da) | 1971-10-18 |
DE2000772C3 (de) | 1982-02-11 |
DE2000772B2 (de) | 1981-06-19 |
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