US3519364A - Applicator - Google Patents

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Publication number
US3519364A
US3519364A US3519364DA US3519364A US 3519364 A US3519364 A US 3519364A US 3519364D A US3519364D A US 3519364DA US 3519364 A US3519364 A US 3519364A
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Prior art keywords
cylinder
plug
liquid
numeral
solution
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Andrew Truhan
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ANDREW TRUHAN
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Andrew Truhan
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A45HAND OR TRAVELLING ARTICLES
    • A45DHAIRDRESSING OR SHAVING EQUIPMENT; MANICURING OR OTHER COSMETIC TREATMENT
    • A45D34/00Containers or accessories specially adapted for handling liquid toilet or cosmetic substances, e.g. perfumes
    • A45D34/04Appliances specially adapted for applying liquid, e.g. using roller or ball
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00Devices for applying, e.g. spreading, media, e.g. remedies, on the human body ; Introducing media, e.g. remedies, into the body by diffusion through the skin
    • A61M35/003Hand-held applicator instruments having media dispensing or spreading means
    • A61M35/006Absorbent pads, e.g. swabs, containing a liquid, e.g. in a rupturable reservoir
    • AHUMAN NECESSITIES
    • A45HAND OR TRAVELLING ARTICLES
    • A45DHAIRDRESSING OR SHAVING EQUIPMENT; MANICURING OR OTHER COSMETIC TREATMENT
    • A45D2200/00Details not otherwise provided for in A45D
    • A45D2200/10Details of applicators
    • A45D2200/1009Applicators comprising a pad, tissue, sponge, or the like
    • A45D2200/1018Applicators comprising a pad, tissue, sponge, or the like comprising a pad, i.e. a cushion-like mass of soft material, with or without gripping means

Description

July 7, 1970 Filed Feb. 3. 1968 A. TRUHAN 3,519,364

APPLIGATOR 2 Sheets-5heet 1 INVENT OR ANDREW TRUHAN ATTORNEYS United States Patent 3,519,364 APPLICATOR Andrew Truhan, RD. 3, Box 392T, Somerset, NJ. 08873 Filed Feb. 2, 1968, Ser. No. 702,664 Int. Cl. A61m 35/00 US. Cl. 401-177 2 Claims ABSTRACT OF THE DISCLOSURE An applicator/swab defined by an elongated tube whose bore is partially filled with a solution. An absonbent wadding is placed around the lower end of the tube, and a plunger within the bore is pushed by the user so as to cause exit of the solution to pass from the bore into the wadding. The wadding is now ready for use as an applicator or swab. In a modification, no plunger is used and the lower end of the tube is fractured to release the solution into the wadding.

This invention generally relates to applicators and/or swabs which contain a reservoir for storage of certain liquid compositions having many and varied applications. The device is particularly useful in that the stored liquid and the applicator per se may be maintained in a sterile condition up to the time of use.

In one aspect the invention relates to a testing device and more particularly to a device for facilitating the culture and subsequent analysis of different types of microorganisms obtained in situ from a living organism such as the human body.

The liquid contained within the applicator may comprise an antiseptic, an antibiotic, an antifungistat or mixtures thereof; cosmetics such such as liquid rouge, liquid lipstick, liquid powder or mascara; or deodorant or personal hygiene substances.

It will be appreciated that one of the primary advantages of the applicator of the invention lies in its single use application, which reduces to a minimum the spread of disease and infection caused by plural use of an applicator.

In the treatment for example of human disease it is often desirable to identify the type of bacteria responsible for an infection. Identification in such cases may be accomplished by growing a culture of bacteria taken from the locus of the infection to thereby facilitate its accurate classification. Further, the preparation or growing of a culture not only enables identification to be made, but certain antibiotics may be applied to the adult culture in order to determine the most effective type which will destroy the particular strain or type of 'bacteria or other microorganism involved. In addition to cultures of bacteria; cultures of cells may also be made in order to observe the effect of distinct virus types on the cells.

According to the practice of this aspect of the invention, a nutrient solution is caused to impregnate an absorbent fibrous or batt material to thereby provide a ready base for growth of a culture. The nutrient solution and the absorbent batt material define the medium for the culture. In general, the nutrient carrier according to this invention is generally elongated and resembles a common swab of cotton placed on the end of a thin stick. A supply of nutrient liquid is stored in the bore of a generally thin-walled and elongated plastic cylinder or tube. A plunger in the form of an elongated piston closes one end of the cylinder while the other end is closed by a plug. The plug may be axially displaceable to thereby permit exudation or discharge of the liquid nutrient from the cylinder when the plunger is pushed, or the plug may be frangible upon an increase of pressure within the bore. In general, the batt or any other fibrous material has the property of absorbing the liquid nutrient after it exists from the cylinder bore.

In the drawings:

FIG. 1 is a cross-sectional view of the applicator according to the practice of this invention;

FIG. 2 is a view similar to FIG. 1 but showing a second modification;

FIG. 3 is a view taken along the line 3-3 of FIG. 2;

FIG. 4 is a view similar to FIG. 1 and showing a third modification;

FIG. 5 is a view similar to FIG. 1, but showing a fourth modification; and

FIG. 6 is a view similar to FIG. 1, but showing a fifth modification.

Referring now to the drawings, the numeral 10 denotes generally an applicator according to this invention and is defined by an elongated cylindrical element 12 conveniently formed of plastic and having relatively thin walls. A ring 14 may be integrally attached to the external wall portion of the cylinder in order to provide an abutment for the fingers. The numeral 16 denotes an elongated plunger, which may be also formed of plastic and which is provided at its upper end with a disc 18 adapted to 'be engaged by the palm or the thumb of the user and whose lower end 20 is generally planar. The numeral 22 denotes a liquid solution which may be any one of a great variety of com-positions. In general, the solution 22 may be characterized as a medium which contains the various minerals, vitamins, proteins, etc., required to support growth of living organisms such as bacteria.

The numeral 24 denotes a plug which closes the lower end of the cylinder 12, the solution 22 effectively encapsulated between the upper portion of plug 24 and the lower portion of the piston 16 may abut another plug, similar to plug 24, instead of directly contacting the upper portion of the encapsulated solution 22. The numeral 26 denotes a wad of batt or other fibrous material, either woven or non-woven and which may be so wrapped or otherwise placed on the end of cylinder 12 to define a limited cavity 28 which communicates with the closed end of cylinder 12. In general, the material 26 may be defined as any material which may be conveniently placed on the end of cylinder 12 and which is absorbent. In addition to cotton, the absorbent pad, wad or batt may comprise silicone or polysiloxane resins, spun fiber or other similar generally inert material.

In a typical use of the device of FIG. 1, the applicator 10 is packaged within a cellophane or the like container in order to maintain the batt relatively sterile or free of dirt, bacteria, moisture, and the like. As set forth above, the device may be shipped and stored encased in an envelope, preferably of brown-colored plastic, to render it substantially opaque, and the envelope may be filled with an inert gas such as nitrogen, which has no effect on the reagent maintained within the bore of the applicator. The reagent is thus protected from the deteriorating effects of light, and the exclusion of oxygen and moisture within the envelope by filling it with nitrogen protects the reagent against oxidation and the like. Thus, the shelf life of the enveloped device is greatly prolonged. The applicator 10 is removed and grasped by the user in such a way that the elongated piston 16 may be pushed downwardly so as to increase the pressure within liquid 22. When the pressure reaches a predetermined amount, the plug 24 is forced from the end of the cylinder 12 into the cavity 28. This is immediately followed by the exudation of the solution 22 into the interior of the batt wad 26. After a limited period of time, the liquid 22 completely permeates or saturates the wadding and at this time the wadding, if the solution is a nutrient, is inoculated, as by actual contact, with bacteria or other living organisms (these organisms being termed the inoculum) which are to be grown. The entire applicator may now be placed in a suitable culture forming environment which is generally a closed chamber with controlled humidity, temperature, and other thermodynamic parameters.

As known to analysts in this field, the mature culture may be examined by well known techniques and apparatus in order to both identify the organisms and also to conduct in vivo experiments on the microorganisms for the most effective type of drugs to control their growth.

Referring now to FIG. 2 of the drawings, the reader will recognize the similarity with the embodiment of FIG. 1. This second embodiment differs in the absence of the recess or cavity 28 in the batt material and in the presence of a plurality of radially disposed holes or openings in the lower portion of the tube 12. FIG. 3 shows generally the angular configuration of these apertures and the reader will gras that with motion of the plunger 16 the plug 24 will be moved downward to such an extent that the fluid 22 will be in communication, successively, with the various axially displaced series of holes 30. This arrangement assures a rather uniform dispersion or application of the fluid throughout the length of the batt wadding 26.

Referring now to FIG. 4 of the drawings, still another modification is illustrated wherein the lower portion of the tube or cylinder 12 is radially expanded and denoted by the numeral 120. The numeral 200 denotes a movable plug of a diameter greater than the upper diameter of the elongated piston 16 and which is positioned at the top surface of the solution 220. The lower portion of the piston is flared to engage the top of plug 200. The numeral 240 denotes a lower plug which seals the solution within the expanded lower portion of the cylinder. Again, the numeral 26 denotes wadding of the same type described with respect to the previously described embodiments and the general mode of operation and cooperation of elements is here substantially the same. By virtue of the expanded diameter of the lower portion of the cylindrical element 12, a greater volume of solution 220 may be impregnated into or exuded into the wadding 26 with the same or lesser longitudinally moving of the piston 16 with respect to the cylinder 12.

Referring now to FIG. of the drawings, an embodiment of the invention is shown which is similar to the embodiment illustrated at FIG. 2 with the addition of a separate encapsulating compartment for a second solution. The numeral 20 denotes a first movable plug which may, as above noted, he simply the bottom of the elongated plunger 16. The numeral 22 denotes a first volume of solution of a first type or sort. The numeral 40 denotes a second or intermediate slidable plug positioned as illustrated within the bore of cylinder 12. The numeral 42 denotes a second volume or body of a solution of a second type and is positioned between plug 40 and a third movable plug 24. In use, the plunger 16 is pushed downwardly and with suflicient downward motion both liquids 42 and 22, successively, penetrate the wadding 26 in substantially the same manner as that set forth with respect to the embodiment of FIG. 2. It will be observed that solutions 22 and 42 may be, for a specific intended use or a specific group of living organisms, incompatible and hence require separation while stored. That is to say, under certain conditions or intended uses, two distinct media may be required, each media contributing its own chemical or nutritional effect to the whole. By the use of the intermediate plug 40, two distinct encapsulation chambers are defined for the media 22 and 42.

Referring now to FIG. 6 of the drawings, yet another embodiment of the invention is illustrated. The numeral 12 again designates a thin-walled tube, generally of plastic, whose upper portion is adapted to be grasped by the hand of the user. A sealing plug 50 is inserted at an intermediate portion of the tube. The numeral 22 again denotes the body of a liquid and, similarly, the numeral 26 again denotes an absorbent webbing formed on or wrapped about the lower portion of the cylinder. The numeral 52 denotes a thin wall defining a lower closure of the type 12 and it will be observed that the side walls 53 may also be thin and may in fact be integral with the lower closure portion 52. It will be appreciated that the thickness of wall portions 52 and 53 is shown much greater than intended, merely for purposes of illustration. The wall portions 52 and 53 are in practice so thin as to be relatively easily frangible or breakable. In use, the upper portion of tube 12 is grasped and the user simply presses the wadding 26 against a relatively unyielding object so as to break or crush the thin walls 52 and 53 and thereby release the encapsulated liquid. Alternatively, the user may simply squeeze the lower portion of the cylinder 12 flexing the walls thereof inwardly and thereby increase the fluid pressure within the liquid medium 22 to such an extent that the wall portions 52 and 53 will break. It will be understood that complete collapse or destruction of the walls 52 and 53 is not required, it being only sufficient or necessary that fissures or cracks occur within the walls to thereby allow the fluid 22 to pass into and impregnate the surrounding wadding 26. In lieu of the illustrated integral construction defined by walls 52, 53 and 12, a thin-walled frangible cap may be inserted over the lower end of tube 12. Similarly, a frangible plug may be inserted within the bottom portion of the bore.

From the preceding description of the mode of operation of the embodiment of FIG. 6, the reader will understand that the other embodiments may similarly include a frangible plug in lieu of the axially slidable plugs 24 or 240 or 40. That is to say, the plugs may either be axially (longitudinally) movable as described or they may simply fracture and thereby allow passage of the fluid.

I claim:

1. An in situ single use culture sampler comprising an elongated cylinder having opposing open first and second end portion, a piston workingly housed in the cylinder and having a plunger portion slidably and sealingly disposed in the cylinder and provided with an outer depressible end portion projecting axially from the first end portion of the cylinder, cooperating gripping means provided on the exterior of the cylinder adjacent to the first end portion thereof and on the outer end portion of the plunger of the piston for enabling the piston to be moved toward the second end portion of the cylinder, said cyl inder containing a liquid culture solution, a wad of fibrous material fitted on and encompassing the second end portion of the cylinder and projecting axially therebeyond and radially therefrom, said wad being internally spaced axially from the second end portion 50 as to have an internal cavity facing the open second end portion and disposed axially beyond and spaced axially from the terminal end of the second end portion of the cylinder and a plug closing off the second end portion inwardly of the cavity, said cavity being of a greater volume than said plug, said plug being forced from its closing off position relative to the second end portion of the cylinder upon movement of the piston toward the second end portion so as to permit the liquid culture to forcibly enter the cavity wherein it gathers and from whence it freely permeates in all directions the wad whereby the Wad will become inoculated with the liquid culture.

2. The invention of claim 1 wherein said second end portion of the cylinder is radially expanded beyond the cylinder and constitutes in its entirety a chamber for the liquid culture, said piston being housed within and movable solely Within the second end portion and having its plunger slidably and sealingly extending through the cylinder from the second end portion to and through the end portion.

first end portion, said plug closing 01f the second end portion and said wad encompassing completely the second References Cited UNITED STATES PATENTS Griswold 215-47 Korn 124-13 Ripley 401-182 Sharp 128-269 Strauss 128269 Bloch 128269 Heimlich 128-269 Sarnoff 35-17 5 EUGENE R. CAPOZIO, Primary Examiner H. S. SKOGQUIST, Assistant Examiner US. Cl. X.R.

Volpini 401-476 x 10 128269; 401-132, 196

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Cited By (69)

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US3739781A (en) * 1972-01-10 1973-06-19 Kimberly Clark Co Tampon inserter arrangement
US3757782A (en) * 1972-06-05 1973-09-11 Vivian C Aiken Fluid pressurizable swab applicator for medicament, antiseptic or the like
US3786814A (en) * 1972-12-15 1974-01-22 T Armao Method of preventing cryoadhesion of cryosurgical instruments and cryosurgical instruments
US3958571A (en) * 1973-08-22 1976-05-25 Bennington William E Swab applicator
US4171171A (en) * 1978-02-07 1979-10-16 Jones Ronald B Long handled liquid dispensing applicator
US4256409A (en) * 1979-06-01 1981-03-17 Manley Douglas C Implement for cleaning the feet
US4329990A (en) * 1980-08-07 1982-05-18 Sneider Vincent R Expanding swab applicator
US4451164A (en) * 1980-07-14 1984-05-29 Roberts Jr James E Dispensing container
US4578055A (en) * 1979-07-25 1986-03-25 Fischer Dan E Controlled diffusion medicament applicator
US4706693A (en) * 1982-09-29 1987-11-17 Donald Spector Cosmetic cream applicator
US4732503A (en) * 1986-08-07 1988-03-22 Wagner Spray Tech Corporation Reservoir fluid dispenser with control valve
US4770171A (en) * 1987-02-12 1988-09-13 Sweren Ronald J Cryogenic surgical tool
US4788985A (en) * 1982-09-30 1988-12-06 Medtest Corporation Device for cell sampling in a body cavity
US4997371A (en) * 1988-06-22 1991-03-05 Honda Giken Kogyo Kabushiki Kaisha Dental agent applicator
US5092013A (en) * 1990-05-07 1992-03-03 Genovese Jr Philip A Disposable toilet seat wipe apparatus with internal actuation
US5151094A (en) * 1990-03-20 1992-09-29 Sage Products, Inc. Suction swab
US5246371A (en) * 1992-08-31 1993-09-21 Ultradent Products, Inc. Method and apparatus for delivery of highly filled, thixotropic sealant to teeth
US5269684A (en) * 1992-08-31 1993-12-14 Ultradent Products, Inc. Adjustable brush delivery tip with secondary flow path
US5490736A (en) * 1994-09-08 1996-02-13 Habley Medical Technology Corporation Stylus applicator for a rehydrated multi-constituent medication
WO1996015724A1 (en) * 1994-11-21 1996-05-30 Chaffringeon, Bernard Single-use device for delivering an active liquid into a body cavity
US5568988A (en) * 1995-07-24 1996-10-29 Courtaulds Aerospace, Inc. Multi-part dispenser
US5843017A (en) * 1990-07-24 1998-12-01 Yoon; Inbae Multifunctional tissue dissecting instrument
US5921972A (en) * 1996-01-11 1999-07-13 Skow; Joseph I. Surgical wicking and fluid removal swab
US5931590A (en) * 1998-03-10 1999-08-03 Harris; Randall C. Sun bathing sponge applicator
US5984555A (en) * 1998-10-02 1999-11-16 Samad; Vicar Dual toilet brush
US6083002A (en) * 1999-02-04 2000-07-04 3M Innovative Properties Co. Cartridge for dispensing liquid compositions
US6095813A (en) * 1999-06-14 2000-08-01 3M Innovative Properties Company Method for applying a dental composition to tooth structure
US6129894A (en) * 1998-12-10 2000-10-10 Drager Sicherheitstechnik Gmbh Device for taking swab samples and sample dilution
US6210057B1 (en) * 2000-04-14 2001-04-03 Thomas R. Yannaci Multipurpose applicator
WO2001076972A1 (en) * 2000-04-05 2001-10-18 Sanford Redmond Inc. Easy opening liquid pouch with swab device
US6467982B1 (en) * 1999-10-28 2002-10-22 Chien-Hwa Tsao Easily opened elongated tubular container
US20020172921A1 (en) * 2001-05-15 2002-11-21 Steven Jensen Fiber tipped dental substance applicator
US6508604B1 (en) 1999-03-19 2003-01-21 The Procter & Gamble Company Article comprising a cell system
US6558362B1 (en) 1999-02-03 2003-05-06 Bernard Chaffringeon Disposable device for transferring an active liquid into a body cavity
WO2003037422A1 (en) 2001-11-02 2003-05-08 Nicolas Trevillot Stick containing a product which the user can bring into contact with an absorbent material
US6585511B2 (en) * 2001-07-16 2003-07-01 Centrix, Inc. Dental material container with porous flow through applicator
US20030153864A1 (en) * 2001-10-16 2003-08-14 Bernard Chaffringeon Disposable device and method for transferring an active liquid into a body cavity
US6620132B1 (en) 1996-01-11 2003-09-16 Joseph I. Skow Surgical irrigation device
US20030195476A1 (en) * 2000-07-20 2003-10-16 Lauree Martin Umbilical cord care apparatus and method of use
US6749356B1 (en) 2003-06-03 2004-06-15 Northrop Grumman Corporation Touch-up coating applicator assembly for remote locations
US6779657B2 (en) 2001-06-06 2004-08-24 Closure Medical Corporation Single-use applicators, dispensers and methods for polymerizable monomer compound
US6811341B2 (en) 2001-08-16 2004-11-02 Closure Medical Corporation Multiple-component combining
US20050069373A1 (en) * 2003-09-26 2005-03-31 Rita Parikh Applicator for cleaning teeth
US20050256483A1 (en) * 2004-04-30 2005-11-17 Przepasniak Ann M Disposable vaginal insertion device
US20060004318A1 (en) * 2004-06-30 2006-01-05 Przepasniak Ann M Disposable device that supplies a material to a vagina
US20060024122A1 (en) * 2004-07-30 2006-02-02 Nealon Joseph M Method and apparatus for applying sealant to fasteners
US20060039742A1 (en) * 2004-08-09 2006-02-23 Cable Frank A Jr Medical skin applicator apparatus
EP1137372B1 (en) * 1998-12-07 2006-06-21 Stick Tech OY A device for use particularly in the reinforcement of teeth or dental prosthetic devices
EP1673237A1 (en) * 2003-09-12 2006-06-28 Garry Tsaur Appicator with two liquids
US20060258971A1 (en) * 2005-03-31 2006-11-16 Chase David J Novel tampon applicator
JP2007203264A (en) * 2006-02-06 2007-08-16 Daisen Sangyo Kk Liquid applicator
US20070276326A1 (en) * 2006-05-03 2007-11-29 Trademark Medical, Llc Oral suction swab
US20080142406A1 (en) * 2006-12-18 2008-06-19 Spatz Laboratories Flexible cosmetic applicator
US20080262407A1 (en) * 2005-03-31 2008-10-23 Chase David J Lubricated Tampon Applicator
US20100049163A1 (en) * 2006-06-27 2010-02-25 Addbio Ab Drug delivery device, kit and method for peroperative local pharmacological treatment of bone surfaces
US20100083773A1 (en) * 2008-10-04 2010-04-08 Eppendorf Ag Sample carrier
US20100167415A1 (en) * 2008-12-30 2010-07-01 Eppendorf Ag Aliquotting device
US20100198166A1 (en) * 2009-02-04 2010-08-05 Tyco Healthcare Group Lp Medical System with Skin Applicator
WO2011018621A3 (en) * 2009-08-10 2011-05-19 Rieke Corporation Applicators
US20120016319A1 (en) * 2010-07-16 2012-01-19 Christian Javier Zino Gutierrez Substance dispenser, especially for medical or cosmetic treatment
US20120189977A1 (en) * 2011-01-21 2012-07-26 Heraeus Kulzer Gmbh Applicator for a dental liquid
USD701600S1 (en) 2011-03-30 2014-03-25 Steven B. Kauffman Ear swab
US20140276627A1 (en) * 2013-03-15 2014-09-18 Acclarent, Inc. Nasal fluid management device
US8899859B2 (en) * 2011-12-16 2014-12-02 Carefusion 2200, Inc. Antiseptic applicator
US9016967B2 (en) 2009-08-10 2015-04-28 Rieke Corporation Applicators
US20160184564A1 (en) * 2014-12-31 2016-06-30 Michael R. Spearman Intranasal delivery device and method of material delivery
US9408756B2 (en) 2013-03-15 2016-08-09 Acclarent, Inc. Nasal fluid management device
US9604041B2 (en) 2013-03-15 2017-03-28 Acclarent, Inc. Nasal fluid management device
US9629990B2 (en) 2012-05-31 2017-04-25 Rieke Corporation Applicators

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Cited By (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3739781A (en) * 1972-01-10 1973-06-19 Kimberly Clark Co Tampon inserter arrangement
US3757782A (en) * 1972-06-05 1973-09-11 Vivian C Aiken Fluid pressurizable swab applicator for medicament, antiseptic or the like
US3786814A (en) * 1972-12-15 1974-01-22 T Armao Method of preventing cryoadhesion of cryosurgical instruments and cryosurgical instruments
US3958571A (en) * 1973-08-22 1976-05-25 Bennington William E Swab applicator
US4171171A (en) * 1978-02-07 1979-10-16 Jones Ronald B Long handled liquid dispensing applicator
US4256409A (en) * 1979-06-01 1981-03-17 Manley Douglas C Implement for cleaning the feet
US4578055A (en) * 1979-07-25 1986-03-25 Fischer Dan E Controlled diffusion medicament applicator
US4451164A (en) * 1980-07-14 1984-05-29 Roberts Jr James E Dispensing container
US4329990A (en) * 1980-08-07 1982-05-18 Sneider Vincent R Expanding swab applicator
US4706693A (en) * 1982-09-29 1987-11-17 Donald Spector Cosmetic cream applicator
US4788985A (en) * 1982-09-30 1988-12-06 Medtest Corporation Device for cell sampling in a body cavity
US4732503A (en) * 1986-08-07 1988-03-22 Wagner Spray Tech Corporation Reservoir fluid dispenser with control valve
US4770171A (en) * 1987-02-12 1988-09-13 Sweren Ronald J Cryogenic surgical tool
US4997371A (en) * 1988-06-22 1991-03-05 Honda Giken Kogyo Kabushiki Kaisha Dental agent applicator
US5151094A (en) * 1990-03-20 1992-09-29 Sage Products, Inc. Suction swab
US5092013A (en) * 1990-05-07 1992-03-03 Genovese Jr Philip A Disposable toilet seat wipe apparatus with internal actuation
US5843017A (en) * 1990-07-24 1998-12-01 Yoon; Inbae Multifunctional tissue dissecting instrument
US5246371A (en) * 1992-08-31 1993-09-21 Ultradent Products, Inc. Method and apparatus for delivery of highly filled, thixotropic sealant to teeth
US5269684A (en) * 1992-08-31 1993-12-14 Ultradent Products, Inc. Adjustable brush delivery tip with secondary flow path
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