US3591329A - Apparatus for preserving hydrophilic gels,more particularly ocular contact lenses - Google Patents
Apparatus for preserving hydrophilic gels,more particularly ocular contact lenses Download PDFInfo
- Publication number
- US3591329A US3591329A US712609A US3591329DA US3591329A US 3591329 A US3591329 A US 3591329A US 712609 A US712609 A US 712609A US 3591329D A US3591329D A US 3591329DA US 3591329 A US3591329 A US 3591329A
- Authority
- US
- United States
- Prior art keywords
- lenses
- liquid
- gel body
- silver
- cation exchanger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000499 gel Substances 0.000 title description 21
- 150000001768 cations Chemical class 0.000 abstract description 19
- 229910052709 silver Inorganic materials 0.000 abstract description 14
- 239000004332 silver Substances 0.000 abstract description 14
- 239000007788 liquid Substances 0.000 abstract description 13
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 11
- 239000000463 material Substances 0.000 abstract description 11
- -1 SILVER IONS Chemical class 0.000 abstract description 7
- 239000011347 resin Substances 0.000 abstract description 5
- 229920005989 resin Polymers 0.000 abstract description 5
- 239000007943 implant Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 9
- 241000233866 Fungi Species 0.000 description 8
- 239000000017 hydrogel Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229940054334 silver cation Drugs 0.000 description 3
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 2
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical class C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000001508 eye Anatomy 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 229910001961 silver nitrate Inorganic materials 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000034303 cell budding Effects 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940116441 divinylbenzene Drugs 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- ZGCHATBSUIJLRL-UHFFFAOYSA-N hydrazine sulfate Chemical compound NN.OS(O)(=O)=O ZGCHATBSUIJLRL-UHFFFAOYSA-N 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/088—Heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
Definitions
- Apparatus for the storage of a swellable hydrophilic polymeric gel body such as a contact lens or other implant comprises a liquid container divided into at least two parts by a porous Wall and having a physiologic liquid contained therein, one of said container parts being adapted to hold said gel body immersed in said liquid, a cation resin exchange material impregnated with a surface active metallic silver, said material being located in the other of the container parts and being soluble by said liquid to release surface silver ions over a period of time to thereafter, freely flow through said porous wall into contact with said gel body.
- the present invention relates to a protective system for preserving and storing swelled hydrophilic polymeric gels as well as articles made therefrom, more particularly ocular contact lenses, which system consists of a room to receive hydrogel, separated by a permeable wall from a room designed for cation exchanger on which silver has been reduced.
- hydrophilic gels have to be preserved or stored in swelled condition, most frequently under water or physiologic solution. In this manner hydrophilic gels are easily liable to get perished which is caused preponderantly by mildew organisms or fungi which grow not only on the surface of the gel but also through its interior and lead to permanent, irreversible degradation thereof. Fungi cause particular troubles in the preparation and application of ocular contact lenses on the basis of glycolmethacrylate gels. The degradation influenced by the growth of fungi is of an irreparable character so that it cannot be suppressed by any of conventional means. The possibility of mildew growth on hydrophilic gels, especially on ocular lenses is one of the main arguments pointed out against wide application of the same.
- the hydrophilic material is stored under water or an aqueous solution while in the other, separated from the former by a permeable partition and communicating therewith, there is deposited a water-swellable polymer containing surface-active silver.
- the shape and arrangement of the system for storing hydrophilic gels can vary according to different application purports.
- EXAMPLE 1 The most simple system to be employed consists of a little bag made of a porous, for example textile fabric manufactured of e.g. polyamide, polyester, cotton, and the like, which bag is filled up with a strongly acidic styrene divinyl-benzene cation exchanger which has been saturated with a solution of silver nitrate whereupon silver was reduced for inst. by means of hydrazine hydrate. The bag of an appropriate size is then put in a receptacle, the hydrophilic gel being stored above the same.
- a porous, for example textile fabric manufactured of e.g. polyamide, polyester, cotton, and the like which bag is filled up with a strongly acidic styrene divinyl-benzene cation exchanger which has been saturated with a solution of silver nitrate whereupon silver was reduced for inst. by means of hydrazine hydrate.
- the bag of an appropriate size is then put in a receptacle
- a double system comprising two compartments each to receive one lens, and a central compartment between two perforated walls designed for silvered cation exchanger, the receptacle being provided with stoppers on either side.
- EXAMPLE 2 For opticians practice there may be recommended well known plain containers made of polystyrene, where silvered cation exchanger is deposited under a false bottom. Alternately, well-known receptacles made of plastic, such as, for example, polypropylene, can be used for storing. For processing conditions it is advantageous to employ, for instance, a tank provided with a false bottom, the silvered cation exchanger being kept in the lower part thereof, in a bag, or in bulk, as referred to in Example 1, while in the upper portion there is arranged a device for depositing, or hanging up the hydrophilic articles to be stored.
- a tank provided with a false bottom
- the silvered cation exchanger being kept in the lower part thereof, in a bag, or in bulk, as referred to in Example 1, while in the upper portion there is arranged a device for depositing, or hanging up the hydrophilic articles to be stored.
- the protective system can be attached to a machine for manufacturing contact lenses, or hydrogel prostheses, preferably adjacent the moulds, since the hydrophilic products may be attacked by fungi within a period of being taken off from the moulds.
- the reduction of silver is carried out by any of Well-known methods, such as, for example, by means of hydrazine hydrate in an alkaline solution, or by means of other strongly reducing agents.
- the grain size of the cation exchanger is to be selected in a suitable range lest individual grains might penetrate through the bag walls.
- the bags may be manufactured in any of well-known manners, such as, for example, by stitching both edges of a plied endless belt lengthwise together, further by a number of spaced transverse stitches, by cutting the stitched belt lengthwise in the middle, filling up the bags formed in such a way with the respective cation exchanger, and finally by stitching both free remaining edges together again.
- a very convenient form of silvered cation exchanger is a membrane which can be cut to pieces which are then lodged under the false bottom or between two perforated partitions of the receptacle.
- Another embodiment consists in lining at least a part of the receptacle for the hydrogel with a silvered cation exchanger. The effect of the silver cation exchanger can be proved by a number of tests as follows:
- Apparatus for the storage of a swellable hydrophilic polymeric gel body such as a contact lens or other implant
- a liquid container divided into at least two parts by a porous wall and having a physiologic liquid contained therein, one of said container parts being adapted to hold said gel body immersed in said liquid, a cation resin exchange material impregnated with a surface active metallic silver, said material being located in the other of the container parts and being soluble by liquid to release surface silver ions over a period of time to thereafter, freely flow through said porous wall into contact with said gel body.
- the resin exchange material comprises a strongly acidic styrenedivinyl-benzene containing surface active metallic silver.
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Ophthalmology & Optometry (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS188367 | 1967-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3591329A true US3591329A (en) | 1971-07-06 |
Family
ID=5354314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US712609A Expired - Lifetime US3591329A (en) | 1967-03-15 | 1968-03-13 | Apparatus for preserving hydrophilic gels,more particularly ocular contact lenses |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US3591329A (de) |
| DE (1) | DE1667942B2 (de) |
| FR (1) | FR1566641A (de) |
| GB (1) | GB1167285A (de) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5340583A (en) * | 1993-05-06 | 1994-08-23 | Allergan, Inc. | Antimicrobial lenses and lens care systems |
| US20030190258A1 (en) * | 2000-11-04 | 2003-10-09 | Smith Francis X. | Ophthalmic and contact lens solutions using low molecular weight amines |
| US6716895B1 (en) | 1999-12-15 | 2004-04-06 | C.R. Bard, Inc. | Polymer compositions containing colloids of silver salts |
| US20040116551A1 (en) * | 1999-12-15 | 2004-06-17 | Terry Richard N. | Antimicrobial compositions containing colloids of oligodynamic metals |
| US20050013842A1 (en) * | 2003-07-16 | 2005-01-20 | Yongxing Qiu | Antimicrobial medical devices |
| US20050042198A1 (en) * | 1999-11-04 | 2005-02-24 | Smith Francis X. | Ophthalmic and contact lens wetting solutions |
| WO2005088351A2 (en) * | 2004-03-17 | 2005-09-22 | Thorkild Andersen | Contact lens, container and insert for avoiding infection of the eye |
| US20060078626A1 (en) * | 2000-11-08 | 2006-04-13 | Bioconcept Laboratories | Opthalmic and contact lens solutions with a peroxide source and a cationic polymeric preservative |
| US20060142169A1 (en) * | 2000-11-08 | 2006-06-29 | Bioconcept Laboratories | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
| US20070098813A1 (en) * | 2000-11-08 | 2007-05-03 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions with a peroxide source and a preservative |
| US20070098818A1 (en) * | 2000-11-08 | 2007-05-03 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
| US20070104744A1 (en) * | 2000-11-08 | 2007-05-10 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing forms of vitamin b |
| US20080167246A1 (en) * | 2003-04-15 | 2008-07-10 | Bioconcept Laboratories | Ophthalmic and Contact Lens Solutions Containing Peptides as Preservative |
| US20080181931A1 (en) * | 2007-01-31 | 2008-07-31 | Yongxing Qiu | Antimicrobial medical devices including silver nanoparticles |
| US7820284B2 (en) | 2001-12-03 | 2010-10-26 | C.R. Bard Inc. | Microbe-resistant medical device, microbe-resistant polymeric coating and methods for producing same |
| US9308264B2 (en) | 2000-11-08 | 2016-04-12 | Fxs Ventures, Llc | Ophthalmic contact lens solutions containing forms of vitamin B |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3038800C2 (de) * | 1980-10-14 | 1982-07-08 | Titmus Eurocon Kontaktlinsen Gmbh & Co Kg, 8750 Aschaffenburg | Behälter für die Pflege und/oder Aufbewahrung von Kontaktlinsen |
| GB8316567D0 (en) * | 1983-06-17 | 1983-07-20 | Contactasol Ltd | Measurement of contact lenses |
| ES2593473B1 (es) * | 2016-10-24 | 2017-09-13 | Disop, S.A. | Producto oftalmológico, método de obtención y método de limpieza y desinfección de lentes de contacto |
-
1968
- 1968-03-07 DE DE1968C0044787 patent/DE1667942B2/de active Granted
- 1968-03-07 GB GB01045/68A patent/GB1167285A/en not_active Expired
- 1968-03-12 FR FR1566641D patent/FR1566641A/fr not_active Expired
- 1968-03-13 US US712609A patent/US3591329A/en not_active Expired - Lifetime
Cited By (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5515117A (en) * | 1993-05-06 | 1996-05-07 | Allergan, Inc. | Antimicrobial lenses and lens care systems |
| US5340583A (en) * | 1993-05-06 | 1994-08-23 | Allergan, Inc. | Antimicrobial lenses and lens care systems |
| US20050042198A1 (en) * | 1999-11-04 | 2005-02-24 | Smith Francis X. | Ophthalmic and contact lens wetting solutions |
| US20100122918A1 (en) * | 1999-11-04 | 2010-05-20 | Smith Francis X | Ophthalmic and contact lens solution |
| US8247461B2 (en) | 1999-11-04 | 2012-08-21 | Smith Francis X | Ophthalmic and contact lens solution |
| US20090293882A1 (en) * | 1999-12-15 | 2009-12-03 | C.R. Bard, Inc. | Antimicrobial compositions containing colloids of oligodynamic metals |
| US20040116551A1 (en) * | 1999-12-15 | 2004-06-17 | Terry Richard N. | Antimicrobial compositions containing colloids of oligodynamic metals |
| US8034454B2 (en) | 1999-12-15 | 2011-10-11 | C.R. Bard, Inc. | Antimicrobial compositions containing colloids of oligodynamic metals |
| US6716895B1 (en) | 1999-12-15 | 2004-04-06 | C.R. Bard, Inc. | Polymer compositions containing colloids of silver salts |
| US7179849B2 (en) | 1999-12-15 | 2007-02-20 | C. R. Bard, Inc. | Antimicrobial compositions containing colloids of oligodynamic metals |
| US8557868B2 (en) | 2000-11-04 | 2013-10-15 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions using low molecular weight amines |
| US20030190258A1 (en) * | 2000-11-04 | 2003-10-09 | Smith Francis X. | Ophthalmic and contact lens solutions using low molecular weight amines |
| US20060142169A1 (en) * | 2000-11-08 | 2006-06-29 | Bioconcept Laboratories | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
| US20070098818A1 (en) * | 2000-11-08 | 2007-05-03 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
| US20070104744A1 (en) * | 2000-11-08 | 2007-05-10 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing forms of vitamin b |
| US9492582B2 (en) | 2000-11-08 | 2016-11-15 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
| US20070098813A1 (en) * | 2000-11-08 | 2007-05-03 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions with a peroxide source and a preservative |
| US9492581B2 (en) | 2000-11-08 | 2016-11-15 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
| US10595532B2 (en) | 2000-11-08 | 2020-03-24 | Fxs Ventures, Llc | Ophthalmic contact lens solutions containing forms of vitamin B |
| US20060078626A1 (en) * | 2000-11-08 | 2006-04-13 | Bioconcept Laboratories | Opthalmic and contact lens solutions with a peroxide source and a cationic polymeric preservative |
| US9308264B2 (en) | 2000-11-08 | 2016-04-12 | Fxs Ventures, Llc | Ophthalmic contact lens solutions containing forms of vitamin B |
| US9585394B2 (en) | 2000-11-08 | 2017-03-07 | Fxs Ventures, Llc | Ophthalmic contact lens solutions containing forms of vitamin B |
| US10064410B2 (en) | 2000-11-08 | 2018-09-04 | Fxs Ventures, Llc | Ophthalmic contact lens solutions containing forms of vitamin B |
| US7820284B2 (en) | 2001-12-03 | 2010-10-26 | C.R. Bard Inc. | Microbe-resistant medical device, microbe-resistant polymeric coating and methods for producing same |
| US20080167246A1 (en) * | 2003-04-15 | 2008-07-10 | Bioconcept Laboratories | Ophthalmic and Contact Lens Solutions Containing Peptides as Preservative |
| US20110212885A1 (en) * | 2003-04-15 | 2011-09-01 | Smith Francis X | Ophthalmic and contact lens solutions containing peptides as preservative |
| US7939501B2 (en) | 2003-04-15 | 2011-05-10 | Smith Francis X | Ophthalmic and contact lens solutions containing peptides as preservative |
| US8425926B2 (en) | 2003-07-16 | 2013-04-23 | Yongxing Qiu | Antimicrobial medical devices |
| US20050013842A1 (en) * | 2003-07-16 | 2005-01-20 | Yongxing Qiu | Antimicrobial medical devices |
| US20080029408A1 (en) * | 2004-03-17 | 2008-02-07 | Thorkild Andersen | Contact Lens, Container And Insert For Avoiding Infection Of The Eye |
| WO2005088351A3 (en) * | 2004-03-17 | 2006-03-16 | Thorkild Andersen | Contact lens, container and insert for avoiding infection of the eye |
| WO2005088351A2 (en) * | 2004-03-17 | 2005-09-22 | Thorkild Andersen | Contact lens, container and insert for avoiding infection of the eye |
| US20080181931A1 (en) * | 2007-01-31 | 2008-07-31 | Yongxing Qiu | Antimicrobial medical devices including silver nanoparticles |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1566641A (de) | 1969-05-09 |
| DE1667942A1 (de) | 1971-06-16 |
| DE1667942B2 (de) | 1977-05-12 |
| GB1167285A (en) | 1969-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3591329A (en) | Apparatus for preserving hydrophilic gels,more particularly ocular contact lenses | |
| AT165549B (de) | Verfahren zur Herstellung von hämostatisch wirkenden Pfropfen und Verbänden | |
| US4782946A (en) | Soft contact lens hydration device and kit | |
| US4860885A (en) | Lens storage system | |
| US4568517A (en) | Disinfection of contact lenses | |
| CA2292513C (en) | Contact lens packing solutions and methods for improving the comfort of disposable contact lenses | |
| US3634123A (en) | Method for making nonthrombogenic surfaces | |
| US4269826A (en) | Physiological preparation containing loaded cells in suspension and a magnetic agent for local concentration thereof in a living body | |
| GB1580546A (en) | Biocompatible hemoperfusion system | |
| US5196174A (en) | Apparatus for sterilizing contact lenses | |
| EP0181075B1 (de) | Petrischale zur Züchtung von Bakterien und Verfahren zur Prüfung der Drogenempfindlichkeit | |
| NO793417L (no) | Medisinsk anordning av blodforenelig polymer | |
| JP2002292654A (ja) | ソコンタクトレンズをプラスチック型から解放するための方法 | |
| JPH0156779B2 (de) | ||
| US4097657A (en) | Surface-treated soft contact lenses | |
| US5431879A (en) | Method and container for sterilizing and disinfecting | |
| NO753778L (de) | ||
| US4976921A (en) | Kit for contact lens sterilization and method for contact lens sterilization | |
| US4379893A (en) | Surface-treated soft contact lenses | |
| CN104815345B (zh) | 一种舰载医用镊子消毒贮存罐及其制备方法 | |
| CN112513637A (zh) | 用于检测生物膜的试剂盒和用于检测生物膜的方法 | |
| JP4742829B2 (ja) | 被浸漬部材用容器 | |
| US3536040A (en) | Selectively permeable receptacle | |
| DE1667942C3 (de) | Verfahren und Vorrichtung zum sterilen Aufbewahren von Gegenständen aus gequollenen Hydrogelen, insbesondere von Kontaktlinsen | |
| Winder et al. | Contact Lenses: Drugs Release and Lens Spoilation |