US3556080A - Skin allergy testing device - Google Patents

Skin allergy testing device Download PDF

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Publication number
US3556080A
US3556080A US719318A US3556080DA US3556080A US 3556080 A US3556080 A US 3556080A US 719318 A US719318 A US 719318A US 3556080D A US3556080D A US 3556080DA US 3556080 A US3556080 A US 3556080A
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United States
Prior art keywords
handle
connector means
heads
point
skin
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Expired - Lifetime
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US719318A
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English (en)
Inventor
Gary L Hein
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LINCOLN LAB Inc
LINCOLN LABORATORIES Inc
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LINCOLN LAB Inc
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Assigned to LINCOLN LABORATORIES, INC. reassignment LINCOLN LABORATORIES, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). EFFECTIVE APRIL 22,1980 Assignors: MERIEUX LABORATORIES INC
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices

Definitions

  • the instant invention seeks to embody a plurality of multipie-point scarifiers in an improved device for effecting multiple spaced skin tests simultaneously.
  • the object of this invention is to provide an improved device for effecting multiple skin tests simultaneously by pressure pu'nctures, and wherein the physician has full view of each scarifier being used and is able to effect substantially identical pressure punctures with each test head of the instrument, even on a nonplanar body portion, thereby insuring uniformity of testing.
  • a further objectof this invention is to provide an improved testing instrument that is characterized by its simplicity and ef- BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 illustrates my new skin-testing instrument and illustrates its use on the forearm of a patient being tested;
  • FIG. 2 is a bottom plan view of the instrument of FIG. 1;
  • FIG. 3 is a side elevational view of the instrument of FIG. 1;
  • FIG. 4 is an end elevational view of the instrument of FIG. I; a
  • FIG. 5 illustrates one method of loading liquid antigenic material onto the points of scarifier heads of the instrument.
  • FIG. 6 is a fragmentary enlarged cross-sectional view illustrating a modified form of the instrument, particularly in the means for preassembling the biological or antigenic material on the points of the scarifier heads of the instrument.
  • FIG. 1 one form of the instrument of this invention is illustrated at 10 and its use is shown on the forearm F of a patient, the hand of the physician or nurse applying the test being designated P.
  • the instrument might be termed centipede shaped and includes an elongated barlike spine or handle 12 having a plurality of elongated connector means 14 extending, in outrigger fashion, laterally from both sides of the spine 12 in directions transversely to the longitudinal axis of handle or spine 12.
  • a multiple-point type pressure puncture head 16 At thedistal end of each armlike connector means l4 is a multiple-point type pressure puncture head 16.
  • the multiple-point head 16 is ofthe type generally disclosed in Kravitz. U.S. Pat. No. 3.136.314 and includes a round base 18, a rectangular or round raised platform 20 centrally ofbase l8, and nine pressure-type points 22 clustered centrally onto platform 20 so as to create a capilllarityv effect between the points for holding liquid material in the interstices or spaces between the points 22.
  • the spine or handle 12 In order that the spine or handle 12 berigid and easily grasped, it is formed with substantial height, about nine-sixteenth inch relative to thickness, about one-eighth inch.
  • the length of bar 12 is about 4 inches.
  • This shape for handle 12 permits easy grasping by the fingers, as seen in FIG. 1; and avoids blocking of view of the'various heads 16.
  • the handle 12 provides substantial strength in its plane, which is used to effect transfer of vertically applied forces from handle 12 through arms 14 to all the multiple-pointed heads 16 so as to effect a plurality of multiple-point pressure puncture tests simultaneously on spaced portions of the skin of a nonplanar body part, as shown in FIG. I.
  • the armlike connector means 14 each joins the lower handle 12 at equally spaced points, about thirteen-sixteenth inch on centers, adjacent the lower edge 12a.
  • the arms 14 are rod-like with a transverse dimension of about one-sixteenth inchthree thirty-seconds inch.
  • Each arm has a horizontal portion 140.
  • a triangular brace web 14d lying in the plane of arm 14, is provided diametrically of the back side of base 18 and between base 18 and arm portion 140, so as to rigidify the attachment of the multiple-pointed head 16 to the distal end of arm 14 without substantially increasing the amount of material used or obstructing the view of each head 16 and its points 22.
  • Each elongated arm 14 is so small in cross section as to provide relative flexibility both at the juncture of arm portion 14a with relatively rigid spine 12, and also at theelbow 14b.
  • arm 14 there may be some bending of arm 14 at its connection with handle 12 in a plurality of directions, such as both in the plane of arm 14 and transversely to said plane.
  • the entire instrument is integrally molded from a' plastic material making the same inexpensive but effective for its intended purpose. After a single use, the instrument may be discarded, thus avoiding any infection, such as transmission of infection hepatitis to a later user.
  • the first system shown in FIG. 5 utilizes a rectangular biologic-carrying base 30 constructed to have 12 wells 32 defined therein for cooperation with the 12 multi-pointed heads 16 of the centipedelike instrument of FIGS. 1-4.
  • the diameter of each well .32 is of a size to admit the circular base 18 of head 16.
  • Each well carries liquid, or semiliquid or semidried material therein positioned to have the points 22 of the head 16 immersed therein.
  • each head 16 may be provided with an annular flange 16a, of greater diameter than base 18 and located at the upper end of base 18, for engagement with portions of base 30 to limit entry of heads 16 into wells 32.
  • Each well 32 may be filled to a desired depth with a different biological material, such as an allergen, with different specific materials being assigned to different wells in a predetermined pattern or arrangement known to the person applying the material and later reading the results of the test.
  • a different biological material such as an allergen
  • the second system of loading the biologic substances on the points 22 of a head 16 is illustrated in FIG. 6 and utilizes the principles disclosed in Burelle et al., U.S. Pat. No. 3,291,129.
  • FIG. 5. including base 30 and instrument assembled. or the separated portions thereof, may
  • the instrument 10 is supplied with each head 16 carrying preassembled thereon the biologic material 44 in tube 42.
  • the tube 42 for each head 16 may then be removed, and the points 22 remain loaded with biologic 44, after which the instrument is used as in FIG. 1.
  • a device for effecting multiple skin tests simultaneously on spaced portions of a nonplanar body part comprising, in combination: a relatively rigid, elongated handle; a plurality of multiple-point, skin-puncturing heads located laterally outwardly of both longitudinal sides of the handle. so that the handle does not obstruct view of the puncturing heads when being used to effect skin tests; and a plurality of elongated connector means for connecting the skin-puncturing heads to the handle; each connector means being of small size dimension relative to its length and being spaced from adjacent connector means so as not to obstruct view of the puncturing heads.
  • each connector means extendinglongitudinally transversely to the longitudinal axis of the a handle and interconnecting at its distal end to one of the multiple-point heads so that the heads may all be pressured from the single handle to effect a plurality of multiple-point pressure puncture tests simultaneously on spaced portions of the skin of a nonplanar body part.
  • the connector means extending outwardly and angling downwardly of the handle means so as to locate the mul-v tiple-point heads in a plane spaced substantially below the handle means.
  • each elongated connector means provides a mounting for the multiple-point skin-puncturing head that permits flexing of each connector means in a plurality of directions at the point of connection of the connector means to the handle.
  • each elongated connector means includes an elbow section intermediate the ends of the connector means to permit additional flexibility.
  • each elongated connector head so as to rigidify the connection of the head to the con- IICCIOI' means.
  • a device as in claim 1 wherein the handle is an elongated barlike body having a greater height than width so as to have strength for transmitting vertically applied forces from the handle to all the multiple-point heads, while affording maximum visibility of the multiple-point heads during a test-applying operation and affording easy gripping of the handle by the fingers.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
US719318A 1968-04-08 1968-04-08 Skin allergy testing device Expired - Lifetime US3556080A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71931868A 1968-04-08 1968-04-08

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US3556080A true US3556080A (en) 1971-01-19

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Cited By (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3688764A (en) * 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3906933A (en) * 1973-04-16 1975-09-23 Lovida Ag Method and apparatus for determination of skin type
USD247822S (en) 1976-03-29 1978-05-02 Lincoln Laboratories, Inc. Support base and holder for use in loading antigenic materials on a multi-applicator skin testing device
WO1980000531A1 (en) * 1978-09-05 1980-04-03 L Brennan Allergy testing system
US4205689A (en) * 1978-09-05 1980-06-03 Aller-Screen, Inc. Allergy testing system
US4222392A (en) * 1979-05-23 1980-09-16 Alier-Screen, Inc. Allergy testing device with vented base
US4270548A (en) * 1979-09-05 1981-06-02 Aller-Screen, Inc. Allergy testing method
US4292979A (en) * 1979-04-09 1981-10-06 Inglefield Jr Joseph T Allergy testing apparatus
DE3102857A1 (de) * 1980-01-31 1981-12-03 Institut Merieux, Lyon, Rhône "vorrichtung zur skarifikation"
US4304241A (en) * 1978-09-05 1981-12-08 Aller-Screen, Inc. Skin testing device
WO1983001308A1 (en) * 1981-10-05 1983-04-14 Mast Medical Ind Ltd Allergy screening system and method of making and using same
US4483348A (en) * 1982-03-25 1984-11-20 Nathan Sher Skin testing device
US4802493A (en) * 1981-12-14 1989-02-07 Maganias Nicholas H Device and method for allergy testing
US5097810A (en) * 1990-04-06 1992-03-24 Henry Fishman Allergy testing apparatus and method
US5139029A (en) * 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
USD360945S (en) 1993-09-27 1995-08-01 Baldwin Robert M Allergy testing needles
US5551441A (en) * 1994-12-09 1996-09-03 Pitesky; Isadore Injection pick holder apparatus
US5588441A (en) * 1986-04-18 1996-12-31 Fishman; Henry Allergy testing apparatus with variably spaced test using sites
US5647371A (en) * 1995-04-12 1997-07-15 Greer Laboratories, Inc. Skin testing device loading method
WO1997024977A1 (en) * 1996-01-11 1997-07-17 Lincoln Diagnostics, Inc. System for multi-site skin testing and components thereof
US5671753A (en) * 1995-06-27 1997-09-30 Pitesky; Isadore Disposable multiple allergen testing apparatus
FR2747558A1 (fr) 1996-04-22 1997-10-24 Hsiao Ray Ling Appareil pour tests d'allergie par piqure sur la peau
US5692518A (en) * 1993-07-02 1997-12-02 Rachman Scientific, Inc. Skin test applicator
GB2317113A (en) * 1996-09-13 1998-03-18 Hsiao Ray Ling Skin allergy test assemblies
US5738108A (en) * 1996-01-11 1998-04-14 Lincoln Diagnostics, Inc. System for multi-site skin testing and components thereof
US5749836A (en) * 1996-03-26 1998-05-12 Hsiao; Ray-Ling Quantitative skin allergic test device
US5944671A (en) * 1993-07-02 1999-08-31 Greer Laboratories, Inc. Skin test applicator
DE29811266U1 (de) * 1998-06-24 1999-11-04 Kerner, Kay, 60431 Frankfurt Vorrichtung zum Lagern und Auftragen von mindestens zwei Testsubstanzen
US6095988A (en) * 1998-09-04 2000-08-01 Greer Laboratories, Inc. Autoloader and skin testing system
US6334856B1 (en) 1998-06-10 2002-01-01 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US20020082543A1 (en) * 2000-12-14 2002-06-27 Jung-Hwan Park Microneedle devices and production thereof
US20020138049A1 (en) * 1998-06-10 2002-09-26 Allen Mark G. Microneedle devices and methods of manufacture and use thereof
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating
US6554777B1 (en) * 2001-08-31 2003-04-29 Gary L. Hein, Jr. Multi-site skin-test system and method
US20030093040A1 (en) * 2001-10-29 2003-05-15 Mikszta John A. Method and device for the delivery of a substance
US20030095582A1 (en) * 2000-12-21 2003-05-22 Ackley Donald E. Microneedle array systems
US20030135158A1 (en) * 2001-09-21 2003-07-17 Gonnelli Robert R. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US20030135167A1 (en) * 2001-09-19 2003-07-17 Gonnelli Robert R. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US20100022910A1 (en) * 2008-07-25 2010-01-28 Welch Allyn, Inc. Rapid allergy test
US8469900B2 (en) 2011-11-30 2013-06-25 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US20130231583A1 (en) * 2012-03-02 2013-09-05 Donna Rekkerth Methods and Compositions for Injection Delivery
US8597199B2 (en) 2010-10-11 2013-12-03 Ziv Harish Reduced-pain allergy skin test device
USD709193S1 (en) * 2013-03-15 2014-07-15 Research Institute At Nationwide Children's Hospital Medical testing apparatus
WO2014150833A1 (en) * 2013-03-15 2014-09-25 The Research Institute At Nationwide Children's Hospital Skin testing apparatus
USD721435S1 (en) 2013-01-15 2015-01-20 Research Institute At Nationwide Children's Hospital Medical marking apparatus
US9011350B2 (en) 2011-11-30 2015-04-21 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US20150289794A1 (en) * 2014-04-11 2015-10-15 Marvin Smollar Allergy skin test applicator, and related testing tray, testing kit and testing method
DE102014106170A1 (de) 2014-05-02 2015-11-05 Roxall Medizin Gmbh Vorrichtung, Einrichtung und Verfahren zum Auf- und Einbringen wenigstens einer Allergen-Testlösung auf und in die Haut eines Körperteils einer zu testenden Person
USD764678S1 (en) 2014-04-11 2016-08-23 Marvin Smollar Allergy testing applicator
USD766455S1 (en) 2014-04-11 2016-09-13 Marvin Smollar Allergy testing tray
US9445762B2 (en) 2012-08-30 2016-09-20 Mystic Pharmaceuticals, Inc. Fully self-contained unit dose devices for allergy skin testing
DE202016102736U1 (de) 2016-05-23 2017-08-25 Johannes Uerscheln Testgerät
DE202016102738U1 (de) 2016-05-23 2017-08-25 Johannes Uerscheln Testgerät
WO2018140968A1 (en) * 2017-01-30 2018-08-02 Richard Caizza Allergy skin testing devices with compressible annular pain-reduction structures
US10653354B2 (en) 2013-03-15 2020-05-19 Research Institute At Nationwide Children's Hospital Medical testing apparatus and method of use

Families Citing this family (2)

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WO1987005200A1 (en) * 1986-03-06 1987-09-11 Wray, Reginald, Charles Skin test kit
WO1988009149A1 (en) * 1987-05-29 1988-12-01 The Royal North Shore Hospital And Area Health Ser Medical testing device

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US2522309A (en) * 1948-12-01 1950-09-12 Frank A Simon Allergy testing instrument
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3289670A (en) * 1964-03-09 1966-12-06 Milo Bundy Corp Device for abrading and applying biologicals to the skin of a patient

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US2522309A (en) * 1948-12-01 1950-09-12 Frank A Simon Allergy testing instrument
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3289670A (en) * 1964-03-09 1966-12-06 Milo Bundy Corp Device for abrading and applying biologicals to the skin of a patient

Cited By (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3688764A (en) * 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3906933A (en) * 1973-04-16 1975-09-23 Lovida Ag Method and apparatus for determination of skin type
USD247822S (en) 1976-03-29 1978-05-02 Lincoln Laboratories, Inc. Support base and holder for use in loading antigenic materials on a multi-applicator skin testing device
WO1980000531A1 (en) * 1978-09-05 1980-04-03 L Brennan Allergy testing system
US4205689A (en) * 1978-09-05 1980-06-03 Aller-Screen, Inc. Allergy testing system
US4304241A (en) * 1978-09-05 1981-12-08 Aller-Screen, Inc. Skin testing device
US4292979A (en) * 1979-04-09 1981-10-06 Inglefield Jr Joseph T Allergy testing apparatus
US4222392A (en) * 1979-05-23 1980-09-16 Alier-Screen, Inc. Allergy testing device with vented base
US4270548A (en) * 1979-09-05 1981-06-02 Aller-Screen, Inc. Allergy testing method
US4453926A (en) * 1980-01-31 1984-06-12 Institut Merieux, Societe Anonyme Scarifier
DE3102857A1 (de) * 1980-01-31 1981-12-03 Institut Merieux, Lyon, Rhône "vorrichtung zur skarifikation"
US4459360A (en) * 1981-10-05 1984-07-10 Mast Medical Industries, Ltd. Multiple-component binding assay system and method of making and using it
WO1983001308A1 (en) * 1981-10-05 1983-04-14 Mast Medical Ind Ltd Allergy screening system and method of making and using same
US4802493A (en) * 1981-12-14 1989-02-07 Maganias Nicholas H Device and method for allergy testing
US4483348A (en) * 1982-03-25 1984-11-20 Nathan Sher Skin testing device
US5588441A (en) * 1986-04-18 1996-12-31 Fishman; Henry Allergy testing apparatus with variably spaced test using sites
US5605160A (en) * 1986-04-18 1997-02-25 Fishman; Henry Allergy testing apparatus with variably spaced test testing sites
US5735288A (en) * 1986-04-18 1998-04-07 Fishman; Henry Allergy testing apparatus with variably spaced test testing sites
US5097810A (en) * 1990-04-06 1992-03-24 Henry Fishman Allergy testing apparatus and method
US5139029A (en) * 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
US5944671A (en) * 1993-07-02 1999-08-31 Greer Laboratories, Inc. Skin test applicator
US5692518A (en) * 1993-07-02 1997-12-02 Rachman Scientific, Inc. Skin test applicator
USD360945S (en) 1993-09-27 1995-08-01 Baldwin Robert M Allergy testing needles
US5551441A (en) * 1994-12-09 1996-09-03 Pitesky; Isadore Injection pick holder apparatus
US5673705A (en) * 1994-12-09 1997-10-07 Pitesky; Isadore Injection pick holder apparatus
US5647371A (en) * 1995-04-12 1997-07-15 Greer Laboratories, Inc. Skin testing device loading method
US5671753A (en) * 1995-06-27 1997-09-30 Pitesky; Isadore Disposable multiple allergen testing apparatus
US5738108A (en) * 1996-01-11 1998-04-14 Lincoln Diagnostics, Inc. System for multi-site skin testing and components thereof
US5792071A (en) * 1996-01-11 1998-08-11 Lincoln Diagnostics System for multi-site skin testing and components thereof
WO1997024977A1 (en) * 1996-01-11 1997-07-17 Lincoln Diagnostics, Inc. System for multi-site skin testing and components thereof
US5749836A (en) * 1996-03-26 1998-05-12 Hsiao; Ray-Ling Quantitative skin allergic test device
FR2747558A1 (fr) 1996-04-22 1997-10-24 Hsiao Ray Ling Appareil pour tests d'allergie par piqure sur la peau
GB2317113A (en) * 1996-09-13 1998-03-18 Hsiao Ray Ling Skin allergy test assemblies
GB2317113B (en) * 1996-09-13 1998-11-11 Hsiao Ray Ling Skin allergy test assembly
WO1998041139A1 (en) 1997-03-14 1998-09-24 Lincoln Diagnostics, Inc. System for multi-site skin testing and components thereof
EP1006867B1 (en) * 1997-03-14 2005-07-06 Lincoln Diagnostics, Inc. System for multi-site skin testing and components thereof
US8708966B2 (en) 1998-06-10 2014-04-29 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US20100312191A1 (en) * 1998-06-10 2010-12-09 Georgia Tech Research Corporation Microneedle Devices and Methods of Manufacture and Use Thereof
US6334856B1 (en) 1998-06-10 2002-01-01 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US20020138049A1 (en) * 1998-06-10 2002-09-26 Allen Mark G. Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
DE29811266U1 (de) * 1998-06-24 1999-11-04 Kerner, Kay, 60431 Frankfurt Vorrichtung zum Lagern und Auftragen von mindestens zwei Testsubstanzen
US6206838B1 (en) 1998-09-04 2001-03-27 Greer Laboratories, Inc. Autoloader and skin testing system
US6095988A (en) * 1998-09-04 2000-08-01 Greer Laboratories, Inc. Autoloader and skin testing system
US8257324B2 (en) 1999-06-04 2012-09-04 Georgia Tech Research Corporation Microneedle drug delivery device
US20070225676A1 (en) * 1999-06-04 2007-09-27 Prausnitz Mark R Microneedle drug delivery device
US7226439B2 (en) 1999-06-04 2007-06-05 Georgia Tech Research Corporation Microneedle drug delivery device
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US20050137531A1 (en) * 1999-11-23 2005-06-23 Prausnitz Mark R. Devices and methods for enhanced microneedle penetration of biological barriers
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US7731968B2 (en) 2000-05-22 2010-06-08 Becton, Dickinson And Company Topical delivery of vaccines
US20080009785A1 (en) * 2000-05-22 2008-01-10 Mikszta John A Topical delivery of vaccines
US9302903B2 (en) 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US20020082543A1 (en) * 2000-12-14 2002-06-27 Jung-Hwan Park Microneedle devices and production thereof
US20030095582A1 (en) * 2000-12-21 2003-05-22 Ackley Donald E. Microneedle array systems
US7027478B2 (en) 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US7963935B2 (en) * 2001-04-20 2011-06-21 Alza Corporation Microprojection array having a beneficial agent containing coating
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating
US6554777B1 (en) * 2001-08-31 2003-04-29 Gary L. Hein, Jr. Multi-site skin-test system and method
US8361037B2 (en) 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135167A1 (en) * 2001-09-19 2003-07-17 Gonnelli Robert R. Microneedles, microneedle arrays, and systems and methods relating to same
US8920375B2 (en) 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20030135158A1 (en) * 2001-09-21 2003-07-17 Gonnelli Robert R. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20090043250A1 (en) * 2001-09-28 2009-02-12 Gonnelli Robert R Microneedle with membrane
US20050137536A1 (en) * 2001-09-28 2005-06-23 Gonnelli Robert R. Microneedle with membrane
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US20090062752A1 (en) * 2001-09-28 2009-03-05 Gonnelli Robert R Switchcable microneedle arrays and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
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DE2100542B2 (de) 1977-04-28
DE2100542A1 (de) 1972-07-20
GB1301930A (https=) 1973-01-04

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