US3549330A - Apparatus for analyzing liquids - Google Patents
Apparatus for analyzing liquids Download PDFInfo
- Publication number
- US3549330A US3549330A US769634A US3549330DA US3549330A US 3549330 A US3549330 A US 3549330A US 769634 A US769634 A US 769634A US 3549330D A US3549330D A US 3549330DA US 3549330 A US3549330 A US 3549330A
- Authority
- US
- United States
- Prior art keywords
- chamber
- liquid
- disc
- containers
- support member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/02—Water baths; Sand baths; Air baths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00376—Conductive heating, e.g. heated plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
- G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
Definitions
- the purposes of the invention are achieved by providing an apparatus having an enclosed chamber containing a rotatable disc on which the sample liquid containers are mounted.
- the lid of the chamber includes a plurality of air-tight fittings through which tubular elements extend to supply liquid to and remove liquid from the containers.
- a shaft extends through the lid into the chamber for supporting the said disc, the shaft being rotatable for moving the containers from station to station.
- the apparatus includes further means for reciprocating the tubular elements, first moving the same downwardly into the containers for supplying and removing liquid thereto and therefrom and then upwardly to permit rotational movement of the said support member, thereby moving the containers to the next station.
- the means for rotating the container support member and the means for reciprocating the tubular elements are interrelated so that rotational movement of the support member is brought about by upward movement of the tubular elements and so that rotational movement of the support is prevented when the tubular elements are moved downwardly into the sample containers.
- FIG. 1 is a sectional elevational view of an apparatus constructed in accordance with the present invention.
- FIG. 2 is a sectional view taken along line 2-2 of FIG. 1.
- FIG. 3 is a partially developed view taken along line 3-3 of FIG. 1.
- 1 designates a hermetically sealed chamber provided with a lid 2 mounted on the chamber 1 by means of a sealing means 3.
- the lid 2 may be of any suitable material but preferably glass or another transparent material.
- the chamber 1 may be filled with a suitable liquid, such as silicone oil, up to a level 4 and is provided with means for heating the liquid, indicated in the drawing in the form of electrical elements '5 connected to a current source.
- the chamber may also contain, in a manner known per se, thermostatically controlled means for maintaining the desired temperature of the liquid as well as means for stirring the same.
- heating of the same is provided, preferably by means of a metallic coating on portions thereof, which are supplied with electric current.
- the chamber 1 is enclosed within another chamber 7 which is placed on supporting blocks 6 within the latter, the chamber 7 having a lid 8. Furthermore, the space 9 between the chamber 1 and the outer chamber 7 is filled with heat-insulating material. Finally, the outer chamber 7 is attached to a base plate 10 of the analyzer. Through a passage 11, which passes through a lead-in 12 which is sealed against the lid 2, the interior of the chamber 1 may be connected to means for maintaining a certain subpressure within the chamber.
- the chamber 1 ispreferably circular as shown in FIG. 2 and has provided therein a disc 13 which is rotatable in a step-by-step manner and which forms a support for a plurality of sample liquid containers such as test tubes 14, few of which are shown on the drawing.
- the disc13" ing means for causing vertical movement of the disc 15 t and for rotating the disc 13 with the test tubes 14 in a step-by-step manner.
- the means for supplying and removing liquid comprise cannulas 19 connected to pumps 20 or the like, which are attached to the vertically movable disc 15.
- the cannulas 19 are inserted in lead-ins 21 which are sealed against the lid 2 and are provided with an O-ring or the like for sealing against the cannula 19.
- the disc 15 is attached via a lower supporting plate 22 to an axially movable piston and cylinder unit 23, piston 24, of which is stationary against vertical movement.
- the piston 24 is attached to a shaft in the form of a tube 25 which is joined to an upper supporting plate 26 which is carriedby the upper plate 18 in a rotatable manner via ball bearings 27.
- the piston 24 partitions the inner space of the piston and cylinder unit 23 into an upper chamber 28 and lower chamber 29, which are connectedvia passages 30 and 31 to a suitable valve member 32 such as a three-way valve. or the like, known per se, by means of which the chambers can be-alternately connected to a source of compressed air 33.
- the disc 15 With the means for supplyingand removing liquid, is made to reciprocate in the vertical direction, the said means being guided bythe guidemembers 16 and 17, a pair of which are shown in FIG. 1, but which are preferably spaced around the circumference as shown in FIG. 2..
- the elements 32 and 33 may be rigidly connected with the disc 15 andfollow its movements in the vertical direction, but they may also be stationary, in which case the passages 30 and 31 must be flexible.
- the upper wall 34 of the piston and cylinder unit23 is provided with means for stepwise rotation of the tube 25 during a certain portionof the vertical movement of the piston and cylinderunit 23 and for locking the tube 25 against rotation during another portion of the vertical movement of the unit 23, the arrangement being adapted to provide a stepwise displacement of the tube 25 when the cannulas 19 are located upwardly away from the test tubes .14 and to provide a locking of the tube 25 against rotation while the cannulas 19 are located in the test tubes 14.
- guide pins 35' are provided on the 7 upper wall 34 cooperating with cam surfaces 39 and with recesses 38 formed between guide rails. 36 attached to longitudinal bars 37 which are attached to the upper support plate 26. These members are shown in more detail in FIG. 3.
- the upper wall 34 is provided with evenly spaced guide pins 35.
- the guide rails 36 form a recessed vertical channel 38 as well as cams 39a.
- Above the pins 35 are further cams 39b.
- a stepwise 4 cams 39a in the vicinity of the upper end position of the vertical movement when the cannulas 19 are above the test tubes 14.
- the guide channel 38 is adapted to co operate with a guide pin 35 inserted therein to lock the members 26, 25, 13 and 14 against rotation during the portion of the operating sequence when the cannulas 19 are located in the test tubes 14.
- the drawing shows means 19, 20 for supplying and removing liquid, and it may be assumed that one of these means, such as the left one is adapted to supply a mixture of sample liquid and reagent liquid to the test tubes 14.
- the desired reaction in the test tubes is assumed to take place.
- the liquid can then be removed and supplied to means for ascertaining the reaction that has taken place, said means comprising, for instance a photometer.
- test tubes are rinsed in known manner, after which fresh test liquid with reagent liquid can be supplied once more through the left-hand means 19, 20.
- the means 19, 20 for supplying and removing liquid do not have to be diagonally positioned, as shown in FIG. 1, but may be placed anywhere around the circumference of the line of test tubes 14 as shown in FIG. 2 so as to provide suitable reaction times for the desired reaction to take place.
- An apparatus for analyzing liquids under controlledpressure conditions comprising a substantially air-tight chamber, a disc mounted insaid chamber for rotation about an axis, said disc including means for holding a plurality of liquid containers for liquid to be analyzed, means for supplying liquid to and removing liquid from said containers while said containers are held by the disc in the chamber, and means for establishing fluid communication with the interior of the chamber for controlling the pressure therein.
- said means for supplying liquid to and removing liquid from the chamber includes at least one tubular element mounted for sliding movement through an air-tight fitting in the top of the chamber, towards and away from said containers.
- An apparatus including moving means for moving the tubular element vertically at least between a lowered position whereat the tubular element enters a container for supplying or removing liquid therefrom, and a raised position for permitting rotation of the disc about a vertical axis relative to the tubular element.
- An apparatus including a support member located above the chamber, and including a plurality of tubular elements held by said support member, and wherein said means for moving the tubular element moves the said support member.
- each tubular element includes a pump mounted on the support member for causing fluid flow through its respective tubular element.
- An apparatus including a shaft passing through the piston and cylinder unit and connected to the disc to cause rotational movement thereof, cam means at the upper end of the shaft for effecting step-bystep rotation of the disc, and guide pins connected to the cylinder for engaging the cam means to rotate the shaft and the disc one step each time that the support member is raised.
- An apparatus including vertical channels formed on the interior of the sleeve below the cam means, wherein said guide pins enter the channels to prevent rotation of the shaft when the support member is moved to the lowered position.
- An apparatus including means for preventing rotation of the disc when the support member is moved to the said lowered position.
- An apparatus including a liquid in the chamber such that the said containers are partially immersed therein, and including means for heating the liquid.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE02022/68A SE327841B (ja) | 1968-02-16 | 1968-02-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3549330A true US3549330A (en) | 1970-12-22 |
Family
ID=20259250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US769634A Expired - Lifetime US3549330A (en) | 1968-02-16 | 1968-10-22 | Apparatus for analyzing liquids |
Country Status (6)
Country | Link |
---|---|
US (1) | US3549330A (ja) |
BE (1) | BE728450A (ja) |
DE (1) | DE1906734C3 (ja) |
FR (1) | FR2002035A1 (ja) |
GB (1) | GB1256916A (ja) |
SE (1) | SE327841B (ja) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933436A (en) * | 1972-08-15 | 1976-01-20 | Nihon Denshi Kabushiki Kaisha | Automatic analyzing apparatus |
US3971630A (en) * | 1975-10-07 | 1976-07-27 | Technicon Instruments Corporation | Apparatus and method for batch-type analysis of liquid samples |
FR2314491A1 (fr) * | 1975-06-11 | 1977-01-07 | Secr Social Service Brit | Appareil destine a l'examen d'echantillons, en particulier pour l'analyse du sang |
US4045179A (en) * | 1975-06-11 | 1977-08-30 | Secretary Of State For Social Services | Temperature control apparatus for use in investigating specimens |
US4058370A (en) * | 1974-07-05 | 1977-11-15 | Osmo Antero Suovaniemi | Apparatus for accurate pipetting of small liquid volumes |
US4113437A (en) * | 1975-08-13 | 1978-09-12 | The Secretary Of State For Social Services | Liquid storage device |
US4126418A (en) * | 1976-04-12 | 1978-11-21 | Elkay Products, Inc. | Cuvette |
US4237733A (en) * | 1978-04-26 | 1980-12-09 | Bodenseewerke Perkin-Elmer & Co. GmbH | Sampling device for measuring instruments |
EP0087028A1 (en) * | 1982-02-13 | 1983-08-31 | Kabushiki Kaisha Toshiba | Automatic chemical analyzer |
FR2536539A1 (fr) * | 1982-11-19 | 1984-05-25 | Seiko Instr & Electronics | Manipulateur chimique |
US4517851A (en) * | 1983-05-20 | 1985-05-21 | Becton Dickinson And Company | System for controlling septum damage |
EP0171140A2 (en) * | 1984-05-15 | 1986-02-12 | The University of Tokyo | Automatic cycling reaction apparatus and automatic analyzing apparatus using the same |
WO1991018295A1 (en) * | 1990-05-21 | 1991-11-28 | Pb Diagnostic Systems, Inc. | Temperature controlled chamber for diagnostic analyzer |
US5171530A (en) * | 1990-02-28 | 1992-12-15 | The Perkin-Elmer Corporation | Vial locator and sensor |
US6146895A (en) * | 1990-03-02 | 2000-11-14 | Tekmar Company | Method of static headspace analyzer |
US20150037212A1 (en) * | 2012-04-17 | 2015-02-05 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Automatic biochemical analyzer |
US10094842B2 (en) | 2014-10-17 | 2018-10-09 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Automatic biochemical analyzer |
CN108930797A (zh) * | 2017-05-23 | 2018-12-04 | 费希尔控制产品国际有限公司 | 用于过程控制阀的模块化阀内件组件 |
GB2591092A (en) * | 2020-01-14 | 2021-07-21 | Stratec Se | Pressure chamber for processing reagents ans liquid samples |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102012020038A1 (de) * | 2012-10-12 | 2014-04-17 | Pharma Test Apparatebau AG | Vorrichtung zur Bestimmung des Reaktionsverhaltens einer festen Arzneiform |
CN105935610B (zh) * | 2016-06-29 | 2018-11-02 | 江阴市正中科教器材有限公司 | 一种水浴加热装置 |
CN105944782B (zh) * | 2016-06-29 | 2017-12-19 | 江阴市正中科教器材有限公司 | 一种旋转加热的水浴加热设备 |
CN108225883B (zh) * | 2016-12-09 | 2020-04-17 | 中国科学院大连化学物理研究所 | 一种固相萃取和吹扫一体化装置和使用方法 |
CN114504979A (zh) * | 2022-01-13 | 2022-05-17 | 许昌市传染病医院 | 一种医疗检测用振动混匀装置 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2583454A (en) * | 1946-07-12 | 1952-01-22 | Standard Oil Dev Co | Pressure titration |
US2879141A (en) * | 1955-11-16 | 1959-03-24 | Technicon Instr | Automatic analyzing apparatus |
US3484206A (en) * | 1965-05-07 | 1969-12-16 | Loebl & Co Ltd Joyce | Chemical sampling apparatus |
US3486859A (en) * | 1966-10-11 | 1969-12-30 | Greiner Electronic Ag | Blood analyzing method and apparatus |
-
1968
- 1968-02-16 SE SE02022/68A patent/SE327841B/xx unknown
- 1968-10-22 US US769634A patent/US3549330A/en not_active Expired - Lifetime
-
1969
- 1969-02-05 GB GB1256916D patent/GB1256916A/en not_active Expired
- 1969-02-11 DE DE1906734A patent/DE1906734C3/de not_active Expired
- 1969-02-14 BE BE728450D patent/BE728450A/xx unknown
- 1969-02-14 FR FR6903599A patent/FR2002035A1/fr not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2583454A (en) * | 1946-07-12 | 1952-01-22 | Standard Oil Dev Co | Pressure titration |
US2879141A (en) * | 1955-11-16 | 1959-03-24 | Technicon Instr | Automatic analyzing apparatus |
US3484206A (en) * | 1965-05-07 | 1969-12-16 | Loebl & Co Ltd Joyce | Chemical sampling apparatus |
US3486859A (en) * | 1966-10-11 | 1969-12-30 | Greiner Electronic Ag | Blood analyzing method and apparatus |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933436A (en) * | 1972-08-15 | 1976-01-20 | Nihon Denshi Kabushiki Kaisha | Automatic analyzing apparatus |
US4058370A (en) * | 1974-07-05 | 1977-11-15 | Osmo Antero Suovaniemi | Apparatus for accurate pipetting of small liquid volumes |
FR2314491A1 (fr) * | 1975-06-11 | 1977-01-07 | Secr Social Service Brit | Appareil destine a l'examen d'echantillons, en particulier pour l'analyse du sang |
US4045179A (en) * | 1975-06-11 | 1977-08-30 | Secretary Of State For Social Services | Temperature control apparatus for use in investigating specimens |
US4113437A (en) * | 1975-08-13 | 1978-09-12 | The Secretary Of State For Social Services | Liquid storage device |
US3971630A (en) * | 1975-10-07 | 1976-07-27 | Technicon Instruments Corporation | Apparatus and method for batch-type analysis of liquid samples |
US4126418A (en) * | 1976-04-12 | 1978-11-21 | Elkay Products, Inc. | Cuvette |
US4237733A (en) * | 1978-04-26 | 1980-12-09 | Bodenseewerke Perkin-Elmer & Co. GmbH | Sampling device for measuring instruments |
EP0087028A1 (en) * | 1982-02-13 | 1983-08-31 | Kabushiki Kaisha Toshiba | Automatic chemical analyzer |
FR2536539A1 (fr) * | 1982-11-19 | 1984-05-25 | Seiko Instr & Electronics | Manipulateur chimique |
US4517851A (en) * | 1983-05-20 | 1985-05-21 | Becton Dickinson And Company | System for controlling septum damage |
EP0171140A3 (en) * | 1984-05-15 | 1987-08-05 | University Of Tokyo | Automatic cycling reaction apparatus and automatic analyzing apparatus using the same |
US4981801A (en) * | 1984-05-15 | 1991-01-01 | University Of Tokyo | Automatic cycling reaction apparatus and automatic analyzing apparatus using the same |
EP0171140A2 (en) * | 1984-05-15 | 1986-02-12 | The University of Tokyo | Automatic cycling reaction apparatus and automatic analyzing apparatus using the same |
US5171530A (en) * | 1990-02-28 | 1992-12-15 | The Perkin-Elmer Corporation | Vial locator and sensor |
US6168759B1 (en) | 1990-03-02 | 2001-01-02 | Tekmar Company | Analyzer transport device |
US6146895A (en) * | 1990-03-02 | 2000-11-14 | Tekmar Company | Method of static headspace analyzer |
US6180060B1 (en) | 1990-03-02 | 2001-01-30 | Tekmar Corporation | Analyzer transport device |
US5207987A (en) * | 1990-05-21 | 1993-05-04 | Pb Diagnostic Systems Inc. | Temperature controlled chamber for diagnostic analyzer |
WO1991018295A1 (en) * | 1990-05-21 | 1991-11-28 | Pb Diagnostic Systems, Inc. | Temperature controlled chamber for diagnostic analyzer |
US20150037212A1 (en) * | 2012-04-17 | 2015-02-05 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Automatic biochemical analyzer |
US9638708B2 (en) * | 2012-04-17 | 2017-05-02 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Automatic biochemical analyzer |
US10094842B2 (en) | 2014-10-17 | 2018-10-09 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Automatic biochemical analyzer |
CN108930797A (zh) * | 2017-05-23 | 2018-12-04 | 费希尔控制产品国际有限公司 | 用于过程控制阀的模块化阀内件组件 |
GB2591092A (en) * | 2020-01-14 | 2021-07-21 | Stratec Se | Pressure chamber for processing reagents ans liquid samples |
Also Published As
Publication number | Publication date |
---|---|
GB1256916A (ja) | 1971-12-15 |
BE728450A (ja) | 1969-07-16 |
FR2002035A1 (ja) | 1969-10-03 |
DE1906734B2 (de) | 1973-08-16 |
SE327841B (ja) | 1970-08-31 |
DE1906734A1 (de) | 1969-09-25 |
DE1906734C3 (de) | 1974-03-28 |
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