US3515126A - Test patch for diagnosing allergies - Google Patents

Test patch for diagnosing allergies Download PDF

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Publication number
US3515126A
US3515126A US658461A US3515126DA US3515126A US 3515126 A US3515126 A US 3515126A US 658461 A US658461 A US 658461A US 3515126D A US3515126D A US 3515126DA US 3515126 A US3515126 A US 3515126A
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United States
Prior art keywords
test
carrier
skin
test piece
contact
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Expired - Lifetime
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US658461A
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English (en)
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Gustav Sigfrid Fregert
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Individual
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0035—Vaccination diagnosis other than by injuring the skin, e.g. allergy test patches

Definitions

  • test patch used in proving the presence or absence of particular contact enzymes includes an adhesive plaster carrier for the test patch which is made of a metal foil and is impervious to liquids and gases. A smaller absorbent test piece is attached to the carrier. When the test patch is attached to the skin the carrier maintains a free zone around the test piece in which the skin can not be contacted or affected by any adhesives. Substances applied to the test piece cannot escape through the impervious carrier.
  • the present invention relates to test patches, and, more particularly, to test patches used in providing the presence or absence of particular allergic contact eczemas.
  • Contact allergies are caused by skin contact with certain substances and result in a reaction by the skin producing an eczema.
  • an eczema occurs each time his skin comes into contact With the actual substance, very small amounts of the substance being sufiicient to cause the occurrence of eczemas.
  • the cause of a contact allergy is specific, i.e., it extends in the specific case only to one or only some particular substances.
  • Conventional test patches used for this purpose are composed of one or several liquid absorbing test pieces arranged on the sticky side of an adhesive plaster carrier. When used in an allergy test, a numbetr of such test pieces are provided with solutions of substances suspected of causing the allergic contact eczema. The test pieces are then applied on the patients skin by means of the adhesive plaster carrier.
  • Conventional test patches have many drawbacks.
  • One drawback is that the plaster carriers are permeable, permitting the test substances absorbed by the test pieces partly or completely to pass out through the carriers, thus greatly limiting the effectiveness of the test patches in producing allergic contact eczemas.
  • a second drawback of the plaster carriers used in conventional test patches is that the adhesive of the carrier adheres to the patients skin causing the occurrence of an erythema which is easily spread to the area of the skin covered by the test piece proper.
  • test substances have been improperly identified as producing allergic contact eczemas as a result of the difliculty of distinguishing and determining the reaction of the test substance to the patients skin from that of the skin reaction to the adhesive mass on the carrier.
  • Other erythema producing substances which 3,515,126 Patented June 2, 1970 "Ice have passed out through the carrier have been improperly eliminated due to their failure to produce an allergic patch test reaction.
  • the carrier for the test patch includes or comprises a layer of material that is liquid and gas impervious.
  • the liquid and gas impervious layer in the carrier comprises an aluminum foil to which the test piece is attached via a plastic foil by heat sealing and without glue or adhesive.
  • test patches in accordance with the present invention may be arranged on a continuous test strip comprising a continuous web of a liquid and gas impervious material, preferably a metal foil, which forms the carrier.
  • the test pieces are placed at spaced intervals along one side of this strip with each test piece being separated from every other test piece by means of apertures in the continuous web.
  • FIG. 1 is a plan view of a test patch in accordance with the present invention.
  • FIG. 2 is an enlarged sectionalview through the test patch taken on line II-II of FIG. 1;
  • FIG. 3 shows a test strip comprising a number of test patches arranged one after the other.
  • the test patch includes a laminated carrier 1 comprising a rectangular-shaped aluminum foil 2 covered on two sides by a plastic foil 3 and 4. One side of the aluminum foil 2 is connected by heat sealing via the plastic foil 3 to a paper foil 5 Without glue.
  • test piece 6 is provided with a solution or Vaseline composition of a test substance suspected to cause allergic contact eczemas on the skin of the patient.
  • the carrier 1 with test piece 6 attached is then applied to a suitable place on the patients skin.
  • the carrier 1 is applied by means of an adhesive plaster attached to the opposite side of the metal foil, said plaster having an area larger than the test patch.
  • the carrier 1, which is wider than the test piece 6, is then pressed with force against the patients skin along the carriers side borders 8 to obtain adherence with the skin so that the test piece 6 is enclosed in a hermetically closed chamber.
  • the formation of a hermetically closed chamber increases the penetration of the test substance applied due to the humidity of the skin and prevents the test substance from passing out through the test patch.
  • the carrier 1 with the attached test piece 6 is removed from the patients skin after about two days. If the test substance causes a contact allergy with the patients skin, a contact eczema in the form of an allergic patch test reaction will have occurred at the place where the test piece 6 with the actual test substance was in contact with the patients skin.
  • the free zone 9 existing between the test piece 6 and the contact side of the plaster carrier 1 prevents the skin reaction to the test substance from being combined with the skin erythema easily caused by a surrounding glue or adhesive mass and also prevents any glue or adhesive from becoming dissolved in the test substance since, as mentioned above, connection of the test piece 6 and paper foil to the carrier 1 is via heat sealing plastic foils 3 and 5, and without the use of glue or adhesive.
  • a number of test patches can be arranged to form a continuous strip or tape, the free zones 9 of the test patches being separated from each other by means of essentially rectangular apertures 10 arranged perpendicularly to the longitudinal direction of the strip such that two neighboring test patches are interconnected by means of two lateral connections 11 which are parallel to each other. By tearing the lateral connections 11, one may separate from the strip an arbitrary number of test patches as desired.
  • test patches in accordance with the present invention my also be used in identifying toxic substances that irritate the patients skin even when these toxic substances do not produce a so-called contact allergy. While these toxic substances may irritate the patients skin without causing the skin to acquire the kind of receptivity necessary to produce an allergic contact eczema, these toxic substances can damage the skin of all persons if the contact is sufliciently intense and of long duration.
  • the carrier may comprise either a resin material, such as polyethylene terephthalate, which is impervious to gas and water vapor or a resin laminate comprising two or several different resin materials such as polyethylene (water impervious layer) and polycarbonate (gas tight layer).
  • a resin material such as polyethylene terephthalate
  • a resin laminate comprising two or several different resin materials such as polyethylene (water impervious layer) and polycarbonate (gas tight layer).
  • a test patch used in proving the presence or absence of particular allergic contact eczemas comprising a test piece of liquid absorbing material, a carrier comprising a layer of liquid and gas impervious metal foil, and a plastic foil arranged between said test piece and said carrier, said test piece being attached to said carrier by heat sealing said plastic foil.
  • a test patch according to claim 1 further comprising a paper foil arranged on the side of said metal foil opposite the side to which said test piece is attached and a second plastic foil arranged between said paper foil and said metal foil, said paper foil being attached to said metal foil by heat sealing said second plastic foil.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
US658461A 1966-08-11 1967-08-04 Test patch for diagnosing allergies Expired - Lifetime US3515126A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE10891/66A SE318060B (enrdf_load_stackoverflow) 1966-08-11 1966-08-11

Publications (1)

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US3515126A true US3515126A (en) 1970-06-02

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ID=20293004

Family Applications (1)

Application Number Title Priority Date Filing Date
US658461A Expired - Lifetime US3515126A (en) 1966-08-11 1967-08-04 Test patch for diagnosing allergies

Country Status (6)

Country Link
US (1) US3515126A (enrdf_load_stackoverflow)
DK (1) DK117976B (enrdf_load_stackoverflow)
FI (1) FI49775C (enrdf_load_stackoverflow)
GB (1) GB1171505A (enrdf_load_stackoverflow)
NL (1) NL154008B (enrdf_load_stackoverflow)
SE (1) SE318060B (enrdf_load_stackoverflow)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3703890A (en) * 1970-08-10 1972-11-28 Milton A Saunders Jr Skin patch test device
EP0006158A1 (de) * 1978-06-09 1980-01-09 Ortrun Mara Dr. Maucher Testpflasterstreifen
US4214592A (en) * 1976-12-31 1980-07-29 Institut Merieux Patch for skin tests
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4543964A (en) * 1983-04-21 1985-10-01 Breneman James C Method for testing for immune responses to food
EP0252044A1 (en) * 1986-06-26 1988-01-07 Pharmacia Ab Test strip and method for epicutaneous testing
US4817594A (en) * 1985-04-18 1989-04-04 Laszlo Juhasz Wound dressings with electrically conductive layers
US4836217A (en) * 1984-10-01 1989-06-06 Fischer Torkel I Hypersensitivity test means
US4917688A (en) * 1987-01-14 1990-04-17 Nelson Research & Development Co. Bandage for transdermal delivery of systemically-active drug
US5179959A (en) * 1986-04-18 1993-01-19 Henry Fishman Allergy testing apparatus and method
US5325864A (en) * 1990-07-20 1994-07-05 Jan Gerber Diagnostic testing device for the skin
US10045759B2 (en) 2010-04-22 2018-08-14 Smarthealth, Inc. Epicutaneous patch test chamber
US10492718B2 (en) 2018-04-09 2019-12-03 Mark R. Drzala Apparatus for assessing skin reactivity to a material
US20210259622A1 (en) * 2010-06-09 2021-08-26 Ibs-80, Llc Ibs related testing and treatment

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450845A (en) * 1982-02-22 1984-05-29 Minneapolis Medical Research Foundation, Inc. Device for shielding human skin from ambient light to facilitate tests performed thereon
US5441048A (en) * 1988-09-08 1995-08-15 Sudor Partners Method and apparatus for determination of chemical species in perspiration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2235436A (en) * 1939-11-03 1941-03-18 Stanley V Laub Medical appliance
US3212495A (en) * 1962-06-22 1965-10-19 Hazleton Lab Inc Sensitivity test patches

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2235436A (en) * 1939-11-03 1941-03-18 Stanley V Laub Medical appliance
US3212495A (en) * 1962-06-22 1965-10-19 Hazleton Lab Inc Sensitivity test patches

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3703890A (en) * 1970-08-10 1972-11-28 Milton A Saunders Jr Skin patch test device
US4214592A (en) * 1976-12-31 1980-07-29 Institut Merieux Patch for skin tests
EP0006158A1 (de) * 1978-06-09 1980-01-09 Ortrun Mara Dr. Maucher Testpflasterstreifen
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4543964A (en) * 1983-04-21 1985-10-01 Breneman James C Method for testing for immune responses to food
US4836217A (en) * 1984-10-01 1989-06-06 Fischer Torkel I Hypersensitivity test means
US4817594A (en) * 1985-04-18 1989-04-04 Laszlo Juhasz Wound dressings with electrically conductive layers
US5179959A (en) * 1986-04-18 1993-01-19 Henry Fishman Allergy testing apparatus and method
EP0252044A1 (en) * 1986-06-26 1988-01-07 Pharmacia Ab Test strip and method for epicutaneous testing
US4917688A (en) * 1987-01-14 1990-04-17 Nelson Research & Development Co. Bandage for transdermal delivery of systemically-active drug
US5325864A (en) * 1990-07-20 1994-07-05 Jan Gerber Diagnostic testing device for the skin
US10045759B2 (en) 2010-04-22 2018-08-14 Smarthealth, Inc. Epicutaneous patch test chamber
US20210259622A1 (en) * 2010-06-09 2021-08-26 Ibs-80, Llc Ibs related testing and treatment
US10492718B2 (en) 2018-04-09 2019-12-03 Mark R. Drzala Apparatus for assessing skin reactivity to a material

Also Published As

Publication number Publication date
SE318060B (enrdf_load_stackoverflow) 1969-12-01
NL6710599A (enrdf_load_stackoverflow) 1968-02-12
FI49775C (fi) 1975-10-10
FI49775B (enrdf_load_stackoverflow) 1975-06-30
DK117976B (da) 1970-06-22
GB1171505A (en) 1969-11-19
NL154008B (nl) 1977-07-15

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