Classifications

• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
  • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
  • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
  • A23G3/343—Products for covering, coating, finishing, decorating
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
  • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
  • A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
  • A23G3/20—Apparatus for coating or filling sweetmeats or confectionery
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
  • A23L25/00—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof
  • A23L25/20—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof consisting of whole seeds or seed fragments
  • A23L25/25—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof consisting of whole seeds or seed fragments coated with a layer
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
  • A61K9/2806—Coating materials
  • A61K9/282—Organic compounds, e.g. fats
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
  • A61K9/2806—Coating materials
  • A61K9/282—Organic compounds, e.g. fats
  • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
  • A61K9/2806—Coating materials
  • A61K9/2833—Organic macromolecular compounds
  • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
  • A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
  • A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
  • A23G2200/06—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing beet sugar or cane sugar if specifically mentioned or containing other carbohydrates, e.g. starches, gums, alcohol sugar, polysaccharides, dextrin or containing high or low amount of carbohydrate

Definitions

• the present invention concerns and has for its object the provision of a sugar coating solution useful for the preparation of coated tablets.
• the sugar coating of medicinal tablets is still performed in accordance with the time-honored procedure whereby a subcoatin-g, a smoothing coating, a finishing coating and a polishing coating are applied to the tablets.
• These operations and the various drying condi tions required take about two to four days to finish coating a batch of tablets. in the coated tablets obtained, the weight of the coating usually approximates the weight of the tablet used.
• the present invention concerns a sugar coating solution comprising in addition to the aqueous sugar solution used, an effective amount of at least:
• the sugar solution employed according to the invention is that usually employed for the preparation of coated tablets. it may contain a monoand/ or dis-accharide in the appropriate concentration, but preferably contains sucrose in an amount from about 40 to about 80%, especially from about 50 to 70%.
• the hexanehexol used in the invention is preferably that obtained from natural hexoses by reduction, such as sorbi-tol, dulcitol or especially mannitol.
• the water soluble salt of an alkyl sulfosuccinate is preferably an alkali metal or ammonium salt, for example that derived from lithium, potassium or especially sodium, of ammonia or an amine, such as a primary, secondary or tertiary lower alkylamine, e.g. methylamine, ethylamine, propyl'amine, butylamine, dimethylamine, diethylamine, trimethylamine or triethylamine.
• the higher alkyl residue e'sterifying preferably both of the carboxyl groups present contains advantageously six to ten carbon atoms, such as 1-, 2- or 3-hexyl, l-heptyl, 1-, 2- or especially 3-octyl, l-nonyl or 4-decyl.
• Such salts are described, for example, in US. Patent Nos. 2,028,091 and 2,176,423.
• the polyglucoside used mainly has the following formula:
• the coating solution of this invention contains the hexanehexol in a range of about 1 to 10%, preferably of about 2 to 8%, but especially of about 4 to 6%, the alkyl sulfosucoinate salt in a range of about 0.01 to 0.5%, preferably of about 0.1 to 0.4% but especially of about 0.2 to 0.3%, and the polyglucoside in a range of about 0.01 to 0.2% preferably of about 0.01 to 0.1% but especially of about 0.02 to 0.05%
• An especially valuable coating solution contains about 50 to sucrose, about 4 to 6% mannitol, about 0.2 to 0.3% of di-3-octyl sodium succinate and about 0.02 to 0.05% of the polyglucoside.
• the coating solution of this invention may contain additional ingredients, for example other surfactants, such as monesters of higher fatty acids with polyhydric alcohols or hydroxyethers, such as those described in J. Pharm. 33, 465 et seq. ('1952), opacifiers, such as talc or especially titanium dioxide, and/or dyes, such as those approved and certified under the provisions of the Federal Food, :Drug and Cosmetic Law, and which preferably are insoluble in water.
• surfactants such as monesters of higher fatty acids with polyhydric alcohols or hydroxyethers, such as those described in J. Pharm. 33, 465 et seq. ('1952)
• opacifiers such as talc or especially titanium dioxide
• dyes such as those approved and certified under the provisions of the Federal Food, :Drug and Cosmetic Law, and which preferably are insoluble in water.
• the solution according to the invention is employed in an amount of about 15 to 50%, preferably of about 20 to 30% of the uncoated tablet.
• tlts use is not limited to pharmaceutical preparations, it may also be used for the coating of confectionary products, e.g. candies, nuts and the like.
• the coating procedure is carried out according to known methods, preferably that described in US. Patent No. 3,141,792.
• the material is placed into the usual coating pan and is sprayed several times with the coating solution of this invention. Between the sprays, the coatings applied to the tablets are dried, preferably by directing heated air into the coating pan. The spraying and drying operations are repeated until the desired coating is obtained. Heat may not be applied to the last coat in order to obtain a smooth surface of the resulting coated tablets. If desired,
• waxes such as bees and carnauba wax, wax mixtures, or synthetic products, such as silicones.
• EXAMPLE 1 8 kg. of a coating solution suflicient for 20 kg. of modified ball tablets each weighing 500 mg.
• the coatings applied are dried by a stream of air heated to 47 C. After the last spray no hot air is applied and the coated tablets are allowed to dry overnight in a drying cabinet. If desired, they can be polished using, for example, a suitable wax, such as carnauba wax, either as the powder or in solution, for example in carbon tetrachloride, isopropanol or a hydrocarbon.
• a suitable wax such as carnauba wax, either as the powder or in solution, for example in carbon tetrachloride, isopropanol or a hydrocarbon.
• EXAMPLE 2 10 kg. of a coating solution sufficient for kg. of tablets each weighing 250 mg.
• EXAMPLE 3 10 kg. of a coating solution sufficient for 25 kg. of tablets each weighing 400 mg.
• a sugar coating solution comprising the basic aqueous sugar solution containing the sugar in a range from about 40 to and at least:
• An aqueous sugar coating solution comprising about 50 to 70% sucrose, about 4 to 6% mannitol, about 0.2 to 0.3% di-3-octyl sodium succinate and about 0.02 to 0.05% of a linear poly-1,3-1S-glucoside containing on every third glucose moiety of the chain a 1,6- 3-glucosido group and of which a 1% aqueous solution shows at 24 C. and in the pH-range between 6.8 and 7.5 a final viscosity of about 2400 to 3000 centipoises.

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• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
• Life Sciences & Earth Sciences (AREA)
• Medicinal Chemistry (AREA)
• Polymers & Plastics (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Food Science & Technology (AREA)
• Pharmacology & Pharmacy (AREA)
• Epidemiology (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Nutrition Science (AREA)
• Medicinal Preparation (AREA)
• Coloring Foods And Improving Nutritive Qualities (AREA)

Applications Claiming Priority (1)

Publications (1)

Family

ID=23821973

Family Applications (1)

Country Status (6)

Cited By (3)

Citations (4)

• 1965
  • 1965-05-25 US US458756A patent/US3421920A/en not_active Expired - Lifetime
• 1966
  • 1966-05-06 CH CH666966A patent/CH480062A/de not_active IP Right Cessation
  • 1966-05-17 DE DE19661617373 patent/DE1617373A1/de active Pending
  • 1966-05-18 GB GB22090/66A patent/GB1144439A/en not_active Expired
  • 1966-05-24 BE BE681485D patent/BE681485A/xx unknown
  • 1966-05-25 BR BR179914/66A patent/BR6679914D0/pt unknown

Patent Citations (4)

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