US3136313A - Automatic hypodermic syringe - Google Patents

Automatic hypodermic syringe Download PDF

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US3136313A
US3136313A US89261A US8926161A US3136313A US 3136313 A US3136313 A US 3136313A US 89261 A US89261 A US 89261A US 8926161 A US8926161 A US 8926161A US 3136313 A US3136313 A US 3136313A
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United States
Prior art keywords
needle
ampoule
syringe
holder
injection
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Expired - Lifetime
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US89261A
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Enstrom Hans Gosta
Fredriksson Rune Gerold
Rudolf A I Lundgren
Nojd John Adolf
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AstraZeneca AB
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Astra AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/247—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst

Definitions

  • a hypodermic syringe which comprises a syringe body, an injection needle, a holder for the injection needle, with the needle with its holder arranged in the body of the syringe so that the front end of the syringe covers and protects the needle when ready for use, an ampoule for a liquid to be injected, a spring arranged so as to force the needle holder with the needle out of its prepared position into an injection position as well as compressing the ampoule so that the liquid is squeezed out through the syringe needle, as well as a retaining catch by which the spring is held taut and released so as to bring about the injection.
  • This hypodermic syringe is characterised by the combination that the needle holder with the hypodermic needle is provided with a backward-pointing perforator and in that the ampoule is compressible and is in its entirety movable in the body of the syringe and is located behind the needle holder, and that its front end has a wall that can be pierced easily by a needle, and that the spring is arranged, when released, to press on the rear end of the ampoule, so as to force the ampoule towards the needle holder, so that the needle is brought into its injection position, the perforator pierces the front wall of the ampoule so that the interior of the ampoule comes into connection with the needle, and the ampoule is compressed so that the injection fluid is forced out through the needle.
  • a fundamental characteristic of the hypodermic syringe according to said Swedish Patent No. 167,846 is that the ampoule is compressible so that the injection fluid can be expelled from the ampoule by the pressure exerted by the spring.
  • the ampoules shown as examples of the compressible type of ampoule all have soft walls and can be collapsed so as to squeeze out the contents.
  • the ampoule can be a socalled cartridge type ampoule.
  • this type of ampoule consists of a cylinder having rigid walls containing a piston which, when forced along inside the cylinder, squeezes out any liquid present in the cylinder.
  • the compressessibility of the ampoule thus arises out of the fact that its volume is decreased when the piston is forced along inside the cylinder.
  • the walls of the cartridge type ampoule consists preferably of glass but other materials, such as plastic or metal are also conceivable, though in general one tries to avoid metal containers for the injection fluid because of the risk that metal ions would be dissolved in the liquid.
  • the piston and the front wall of the cartridge type ampoule may be made of rubber or plastic. In ampoules which may be stored for long periods plastic may be preferred, owing to its lower permeability, which results in a lower rate of evaporation of the injection liquid.
  • the syringe illustrated in FIG. 1 comprises a syringe body 1, the front part of which contains a hollow injection needle 2 and a cartridge ampoule 4.
  • the injection needle is mounted in a needle holder 3 which can 3,136,313 Patented June 9, 1964 be moved along the body of the syringe.
  • the rear end 7 of the injection needle extends backwards from the needle holder 3 and is sharpened to a point for piercing.
  • the front end of the syringe body 1 is sealed by means of a rubber membrane 9. Inside this membrane there is a plate 10 with a hole through the middle. This plate serves to steer the needle when it is driven forward into the operating position.
  • the front end of the cartridge type ampoule 4 is sealed by means of a rubber membrane 8, while its rear end is sealed by means of a rubber piston 11 which is arranged to fit tightly during its introduction into the cartridge.
  • a number of preferably three or four, flexible fins 6 which are furnished with heels 12 arranged to engage with a flange 13 on a piston rod 14 which is arranged inside the syringe body.
  • This piston rod 14 is actuated by a coil spring 5 which pushes it in the direction of the cartridge ampoule 4.
  • the rear end of the syringe body is enclosed by a cover 15 which is equipped with projections 19 fixed to the inside of the bottom and arranged to engage with the outer ends 20 of the fins 6 and to force these outwards when the cover 15 is pressed down to its extreme position.
  • a flexible split ring 16 provided with a handle 18, preferably in the shape of a nylon cord, arranged round the body of the syringe so that it is partly against the edge 13 on the piston rod 14.
  • the spring 5 now forces the piston rod down into the body of the syringe so that it presses against the piston 11 of the cartridge type ampoule.
  • the rod 14 pushes the whole catridge type ampoule 4 forwards so that the perforator 7 pierces the front wall 8 of the ampoule, thereafter the ampoule pushes the needle holder 3 and the needle 2 forwards so that the needle pierces the rubber membrane 9 and is brought into position for injecting. T hereupon the piston rod 14 pushes the piston 11 into the cartridge type ampoule, causing the injection fluid to be forced out through the needle 2.
  • FIG. 2 shows an embodiment in which the upper portion of the syringe, containing the automatic operating mechanism, is the same as illustrated in FIG. 1 and is designated by the same reference numerals.
  • the new features are the ampoule and the needle holder.
  • the cartridge type ampoule 21 of FIG. 2 is preferably made of plastic. Its front Wall has a portion 26 of a thickness suitable for being pierced by the rear end 25 of the hypodermic needle 24.
  • the front wall of the ampoule has also protruding portions, forming a ring-shaped groove 28.
  • the hypodermic needle 24 is mounted in a needle-holder 31, which has a cylindrical portion 27 arranged to engage with said groove 28 in the ampoule.
  • a protruding rim 29 on the wall of the groove 28 engages with a corresponding groove on the surface of the cylindrical portion 27 of the needle-holder.
  • the needle-holder is loosely held by the ampoule.
  • the needle 24 is enclosed in a protective cover having the shape of a bellows 30.
  • the front end of the bellows, surrounding the needle, is closed, and keeps the needle sterile.
  • the rear end of the bellows is mounted on the needleholder 31.
  • the bellows is preferably made of rubber or plastic.
  • the rod 14 pushes the ampoule-needle assembly downwards, so that the needle 24 pierces the bel lows 30 and the rubber membrane 9 and enters into its operative position.
  • the ampoule 21 still continues its forward movement, viz. so far that the rim 29 disengages its corresponding groove, and the cylindrical portion 27 engages with the bottom of the rings-shaped groove 28.
  • the rear end 25 of the needle pierces the thin arnpoule wall 26.
  • the rod now pushes the piston into theampoule, and the liqui is pressed out through the needle.
  • the loose combination of the arnpoule and the needle-- holder provides a guarantee that the rear end of the needle does not pierce the ampoule until the needle has reached its operative position.
  • the ampoule and the needle with its holder and its protective cover form an assembly which is easy to handle and which may be sterilized in one operation.
  • An automatic hypodermic syringe comprising a syringe body with an easily pierced front end; a cover enclosing the rear end of the syringe body; an injection needle; a holder for the injection needle, the needle with its holder being arranged in the syringe body so that the easily pierced front end of the syringe body, when prepared for use, completely encloses and protects the needle; a cartridge-type ampoule with rigid side Walls, with a movable rear end and with an immovable front Wall having an easily pierced thin portion, said ampoule containing an injection liquid and being in its entirety within and movable in the syringe body behind the needle-holder, said ampoule are combined to form an assembly and are loosely secured in a position in which the needle is separated from the interior portion by the thin portion of needle-holder being separate from and movable relative to said arnpoule but said needle-holder and said the immovable front Wall of
  • said spring when released, causes the piston rod to exert pressure on the rear end of the ampoule and thereby forces the arnpoule toward the needle holder so that the needle .is brought from a prepared position into a position for injection by piercing the front end of the syringe body with the needle piercing the front wall of the arnpoule only after it is in injection position so that the interior of the ampoule comes into connection with the needle and the movable rear end of the ampoule pressing so that the injection fluid is subsequently forced out through the needle, the recited elements being joined so as to form a unitarydevice.

Description

June 1964 H. G. ENsTRbM ETAL 3,135,313
AUTOMATIC HYPODERMIC SYRINGE Filed Feb. 14, 1961 United States Patent Swedish Patent No. 167,846 deals with a hypodermic syringe which comprises a syringe body, an injection needle, a holder for the injection needle, with the needle with its holder arranged in the body of the syringe so that the front end of the syringe covers and protects the needle when ready for use, an ampoule for a liquid to be injected, a spring arranged so as to force the needle holder with the needle out of its prepared position into an injection position as well as compressing the ampoule so that the liquid is squeezed out through the syringe needle, as well as a retaining catch by which the spring is held taut and released so as to bring about the injection. This hypodermic syringe is characterised by the combination that the needle holder with the hypodermic needle is provided with a backward-pointing perforator and in that the ampoule is compressible and is in its entirety movable in the body of the syringe and is located behind the needle holder, and that its front end has a wall that can be pierced easily by a needle, and that the spring is arranged, when released, to press on the rear end of the ampoule, so as to force the ampoule towards the needle holder, so that the needle is brought into its injection position, the perforator pierces the front wall of the ampoule so that the interior of the ampoule comes into connection with the needle, and the ampoule is compressed so that the injection fluid is forced out through the needle.
A fundamental characteristic of the hypodermic syringe according to said Swedish Patent No. 167,846 is that the ampoule is compressible so that the injection fluid can be expelled from the ampoule by the pressure exerted by the spring. In Patent 167,846, the ampoules shown as examples of the compressible type of ampoule, all have soft walls and can be collapsed so as to squeeze out the contents.
It has now been found that the ampoule can be a socalled cartridge type ampoule. In principle, this type of ampoule consists of a cylinder having rigid walls containing a piston which, when forced along inside the cylinder, squeezes out any liquid present in the cylinder. The compressessibility of the ampoule thus arises out of the fact that its volume is decreased when the piston is forced along inside the cylinder.
The walls of the cartridge type ampoule consists preferably of glass but other materials, such as plastic or metal are also conceivable, though in general one tries to avoid metal containers for the injection fluid because of the risk that metal ions would be dissolved in the liquid.
The piston and the front wall of the cartridge type ampoule may be made of rubber or plastic. In ampoules which may be stored for long periods plastic may be preferred, owing to its lower permeability, which results in a lower rate of evaporation of the injection liquid.
The accompanying drawing shows two embodiments of the hypodermic syringe according to the invention.
The syringe illustrated in FIG. 1 comprises a syringe body 1, the front part of which contains a hollow injection needle 2 and a cartridge ampoule 4. The injection needle is mounted in a needle holder 3 which can 3,136,313 Patented June 9, 1964 be moved along the body of the syringe. The rear end 7 of the injection needle extends backwards from the needle holder 3 and is sharpened to a point for piercing. The front end of the syringe body 1 is sealed by means of a rubber membrane 9. Inside this membrane there is a plate 10 with a hole through the middle. This plate serves to steer the needle when it is driven forward into the operating position.
The front end of the cartridge type ampoule 4 is sealed by means of a rubber membrane 8, while its rear end is sealed by means of a rubber piston 11 which is arranged to fit tightly during its introduction into the cartridge.
At the rear end of the syringe body there are mounted a number of preferably three or four, flexible fins 6 which are furnished with heels 12 arranged to engage with a flange 13 on a piston rod 14 which is arranged inside the syringe body. This piston rod 14 is actuated by a coil spring 5 which pushes it in the direction of the cartridge ampoule 4.
The rear end of the syringe body is enclosed by a cover 15 which is equipped with projections 19 fixed to the inside of the bottom and arranged to engage with the outer ends 20 of the fins 6 and to force these outwards when the cover 15 is pressed down to its extreme position. To prevent an involuntary release of the mechanism there is a flexible split ring 16 provided with a handle 18, preferably in the shape of a nylon cord, arranged round the body of the syringe so that it is partly against the edge 13 on the piston rod 14. The spring 5 now forces the piston rod down into the body of the syringe so that it presses against the piston 11 of the cartridge type ampoule. At first the rod 14 pushes the whole catridge type ampoule 4 forwards so that the perforator 7 pierces the front wall 8 of the ampoule, thereafter the ampoule pushes the needle holder 3 and the needle 2 forwards so that the needle pierces the rubber membrane 9 and is brought into position for injecting. T hereupon the piston rod 14 pushes the piston 11 into the cartridge type ampoule, causing the injection fluid to be forced out through the needle 2.
FIG. 2 shows an embodiment in which the upper portion of the syringe, containing the automatic operating mechanism, is the same as illustrated in FIG. 1 and is designated by the same reference numerals. The new features are the ampoule and the needle holder.
The cartridge type ampoule 21 of FIG. 2 is preferably made of plastic. Its front Wall has a portion 26 of a thickness suitable for being pierced by the rear end 25 of the hypodermic needle 24. The front wall of the ampoule has also protruding portions, forming a ring-shaped groove 28. The hypodermic needle 24 is mounted in a needle-holder 31, which has a cylindrical portion 27 arranged to engage with said groove 28 in the ampoule. A protruding rim 29 on the wall of the groove 28 engages with a corresponding groove on the surface of the cylindrical portion 27 of the needle-holder. Thus, the needle-holder is loosely held by the ampoule.
The needle 24 is enclosed in a protective cover having the shape of a bellows 30. The front end of the bellows, surrounding the needle, is closed, and keeps the needle sterile. The rear end of the bellows is mounted on the needleholder 31. The bellows is preferably made of rubber or plastic.
When the operating mechanism of the syringe of FIG. 2 is released, the rod 14 pushes the ampoule-needle assembly downwards, so that the needle 24 pierces the bel lows 30 and the rubber membrane 9 and enters into its operative position. When the needle-holdr 31' has reached its extreme bottom position, the ampoule 21 still continues its forward movement, viz. so far that the rim 29 disengages its corresponding groove, and the cylindrical portion 27 engages with the bottom of the rings-shaped groove 28. During this movement the rear end 25 of the needle pierces the thin arnpoule wall 26. The rod now pushes the piston into theampoule, and the liqui is pressed out through the needle.
The loose combination of the arnpoule and the needle-- holder provides a guarantee that the rear end of the needle does not pierce the ampoule until the needle has reached its operative position. The ampoule and the needle with its holder and its protective cover form an assembly which is easy to handle and which may be sterilized in one operation.
What is claimed is:
An automatic hypodermic syringe comprising a syringe body with an easily pierced front end; a cover enclosing the rear end of the syringe body; an injection needle; a holder for the injection needle, the needle with its holder being arranged in the syringe body so that the easily pierced front end of the syringe body, when prepared for use, completely encloses and protects the needle; a cartridge-type ampoule with rigid side Walls, with a movable rear end and with an immovable front Wall having an easily pierced thin portion, said ampoule containing an injection liquid and being in its entirety within and movable in the syringe body behind the needle-holder, said ampoule are combined to form an assembly and are loosely secured in a position in which the needle is separated from the interior portion by the thin portion of needle-holder being separate from and movable relative to said arnpoule but said needle-holder and said the immovable front Wall of the ampoule that is easily pierced thereby; means for piercing the pierceable front end of the syringe body with the needle before piercing the pierceable thin portion of the front wall of the ampoule; a spring and a cooperating piston rod disposed in the syringe body between the cover and the ampoule to act on the movable rear end of the ampoule; a retaining catch disposed in said cover by which the spring is held taut before it is released so'as to bring about the injection,
said spring, when released, causes the piston rod to exert pressure on the rear end of the ampoule and thereby forces the arnpoule toward the needle holder so that the needle .is brought from a prepared position into a position for injection by piercing the front end of the syringe body with the needle piercing the front wall of the arnpoule only after it is in injection position so that the interior of the ampoule comes into connection with the needle and the movable rear end of the ampoule pressing so that the injection fluid is subsequently forced out through the needle, the recited elements being joined so as to form a unitarydevice.
References Cited in the file of this patent UNITED STATES PATENTS France Apr. 27, 1959
US89261A 1954-10-27 1961-02-14 Automatic hypodermic syringe Expired - Lifetime US3136313A (en)

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SE154960 1954-10-27

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Cited By (38)

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US3330279A (en) * 1963-10-18 1967-07-11 Sarnoff Automatic hypodermic syringe
US3426448A (en) * 1967-02-02 1969-02-11 Stanley J Sarnoff Training injection device
US3882863A (en) * 1973-08-01 1975-05-13 Survival Technology Hypodermic injection device having cannula covered with resilient sheath
US4194505A (en) * 1978-09-15 1980-03-25 Vac-O-Cast, Inc. Containerized hypodermic module
US4258713A (en) * 1979-07-23 1981-03-31 Wardlaw Stephen C Automatic disposable hypodermic syringe
US4316463A (en) * 1981-01-26 1982-02-23 Vac-O-Cast, Inc. Corrosive protected hypodermic module
EP0070594A2 (en) * 1981-07-21 1983-01-26 Tatoprint Nederland B.V. Tatooing device and program carrier therefore
US4767413A (en) * 1987-04-20 1988-08-30 Habley Medical Technology Corporation Dental syringe having an automatically retractable needle
EP0288443A1 (en) * 1987-04-14 1988-10-26 Astra Meditec AB Automatic two-chamber injector, method for mixing and injecting, and injector cartridge
US4822340A (en) * 1985-10-11 1989-04-18 Duphar International Research B.V. Automatic injector
US5080648A (en) * 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
US5102393A (en) * 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US5167632A (en) * 1992-01-24 1992-12-01 New Potency Products, Inc. Syringe
WO1994007553A1 (en) * 1992-10-05 1994-04-14 Senetek Plc Medicament injectors and methods
US5354287A (en) * 1991-01-16 1994-10-11 Senetek Plc Injector for delivering fluid to internal target tissue
WO1995031235A1 (en) * 1994-05-16 1995-11-23 Washington Biotech Corporation Modular automatic or manual emergency medicine injection system
EP0700307A1 (en) * 1993-05-27 1996-03-13 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5700244A (en) * 1992-04-17 1997-12-23 Science Incorporated Fluid dispenser with fill adapter
US5709668A (en) * 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
US6276567B1 (en) 1999-03-29 2001-08-21 Hydrus, Inc. Pressurized fluid delivery apparatus
US20060030816A1 (en) * 2004-08-09 2006-02-09 Boris Zubry Medical injection system
US20080058732A1 (en) * 2006-08-30 2008-03-06 Arthur Harris Continuous Feed Hypodermic Syringe with Self Contained Cartridge Dispenser
US8162887B2 (en) 2004-06-23 2012-04-24 Abbott Biotechnology Ltd. Automatic injection devices
US20130338593A1 (en) * 2010-12-22 2013-12-19 Robert Wozencroft Autoinjector having a contact surface to provide resistance to movement of a trigger element towards said firing position
US8636704B2 (en) 2009-04-29 2014-01-28 Abbvie Biotechnology Ltd Automatic injection device
US8679061B2 (en) 2006-06-30 2014-03-25 Abbvie Biotechnology Ltd Automatic injection device
US8708968B2 (en) 2011-01-24 2014-04-29 Abbvie Biotechnology Ltd. Removal of needle shields from syringes and automatic injection devices
US8758301B2 (en) 2009-12-15 2014-06-24 Abbvie Biotechnology Ltd Firing button for automatic injection device
US20150283323A1 (en) * 2012-10-17 2015-10-08 Oval Medical Technologies Limited Automatic drug delivery devices
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
CN105688314A (en) * 2016-03-29 2016-06-22 中国人民解放军军事医学科学院实验仪器厂 Automatic injection device
US9833579B2 (en) 2010-08-19 2017-12-05 Novo Nordisk A/S Medical injection device
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Publication number Publication date
DK97966C (en) 1964-02-10
GB933976A (en) 1963-08-14
CH383558A (en) 1964-10-31

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