US3081330A - Thionophosphinic acid esters and process for their production - Google Patents

Thionophosphinic acid esters and process for their production Download PDF

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US3081330A
US3081330A US44537A US4453760A US3081330A US 3081330 A US3081330 A US 3081330A US 44537 A US44537 A US 44537A US 4453760 A US4453760 A US 4453760A US 3081330 A US3081330 A US 3081330A
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acid esters
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Schrader Gerhard
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Bayer AG
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32Esters thereof
    • C07F9/3205Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3229Esters of aromatic acids (P-C aromatic linkage)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A01N57/22Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing aromatic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32Esters thereof
    • C07F9/3205Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211Esters of acyclic saturated acids which can have further substituents on alkyl

Definitions

  • the present invention relates to and has as its objects new and useful insecticidal thiophosphinic acid esters and processes for their production.
  • the new compounds of this invention may be represented by the following general formula R1 Aryl-P OR in which Aryl stands for an arylradical, R for an arbitrarily substituted alkyl radical and R for preferably low molecular weight alkyl radicals.
  • aryl-thiolphosphonites of the following constitution (11) Aryl- P I (II) SH can be, easily obtained in known manner 'with hydrogen sulfide. These aryl-thiophosphonites react with alkali with the formation of the isomeric compounds of the following constitution (III) R s H Alkali ll Aryl-P Aryl-P V (II) p (III) 2 .
  • the symbols have the same significance as given in the above said first formula.
  • radical R may be a lower alkyl radiice
  • white cabbage has been sprayed drip wet with aqueous emulsions as prepared above in a concentration as shown below. Caterpillars (10 each) have been placed on the sprayed leaves of the white cabbage. The living status has been determined after 24 and 48 hours. The following results have been obtained:
  • Aqueous concentration in Killing rate Compound percent; active (in percent) ingredient/ water (I)--. (II) 0.1 100
  • a sodium ethylate solution containing 0.25 mol of dissolved sodium is added thereto at 20 C. while stirring.
  • 32 grams of chloro-acetic acid ethyl ester are added dropwis'e at 40 C.
  • the mixture is further heated to 60 C. for an hour and then worked up as described in Example 1.
  • 52 grams of the new ester of RP. 78 C./0.0l mm. Hg are thus obtained as a water-insoluble colorless oil. Yield: 76% of the theoretical. Spider mites are killed completely with 0.1% solutions.
  • Example 5 47 grams (0.25 mol) of phenyl-ethyl-thiolphosphonite are dissolved in 50 ml. of methanol. A sodium methylate solution containing 0.25 mol of dissolved sodium is added thereto at 20 C. Subsequently 46 grams of OL-bI'OlIlO- propionic acid ethyl ester are added dropwise at 40 C. while stirring is continued. The mixture is heated to 60 C. for another hour and then worked up as described in Example 1. 35 grams of the new ester of BF. 78 C./0.0l mm. Hg are thus obtained as a colorless water-insoluble oil. Yield: 49% of the theoretical.
  • R is a lower alkyl radical and R is a lower alkyl radical W OR having up to 4 carbon atoms.
  • aryl is chloro-substituted phenyl
  • R is a lower 5 R fe enc s Cited in the fil f i patent alkylene radical having up to 4 carbon atoms, R;, 1s a Kamai et a1: Zhun Obshchei Khim, 28, 939 941 lower alkyl radical and R is a lower alkyl radical having (1958) cited in Chem Abs 52 17162 (1958) up to 4 carbon atoms.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

United States-Patent O h 3,081,330 THIONOPHOSPHINIC ACID STERS AND PROCESS FOR THEIR PRODUCTION Gerhard Schrader, Wuppertal-C'ronenberg, Germany, as-
signor to Farbenfabriken Bayer Aktiengesellschaft,
Leverkusen, Germany, a corporation of Germany No Drawing. Filed July 22, 1960, Ser. No. 44,537 Claims priority, application Germany Aug. 21, 1959 5 Claims. (Cl. 260-461) The present invention relates to and has as its objects new and useful insecticidal thiophosphinic acid esters and processes for their production. Generally the new compounds of this invention may be represented by the following general formula R1 Aryl-P OR in which Aryl stands for an arylradical, R for an arbitrarily substituted alkyl radical and R for preferably low molecular weight alkyl radicals.
Ester chlorides of arylphosphonous acids having the following constitution (I) V Aryl-P 01 are known in the literature. H
From these ester chlorides, aryl-thiolphosphonites of the following constitution (11) Aryl- P I (II) SH can be, easily obtained in known manner 'with hydrogen sulfide. These aryl-thiophosphonites react with alkali with the formation of the isomeric compounds of the following constitution (III) R s H Alkali ll Aryl-P Aryl-P V (II) p (III) 2 .In the foregoing formulae the symbols have the same significance as given in the above said first formula.
In accordance with the present invention it has now been found that the aforementioned 'aryl thiolphosphonites, when reacted with alkyl halides in the presence of acid-binding agents, easily form aryl-alkyl-thionophosphinic acid esters of the following general formulae:
R MRI- l Aryl-P SH OR In this reaction scheme the symbols again have the same significance as given in the above said first formula.
More specifically the radical R may be a lower alkyl radiice As examples for the special utility of the inventive compounds the esters of the following formulae ii CH2CHz-SC2H5 021150 on. i -cn-co-oonn cirno on:
have been tested against spider mites, flies and caterpillars. Aqueous solutions of the aforementioned compounds have been prepared by admixing them with the same amount of an auxiliary solvent (acetone). A commercial emulsifier (benZyl hydroxy diphenyl polyglycol ether) is added in an amount of 20% referred to active ingredient. This premixture then is diluted with water to the desired concentration. The tests have been carried out as follows:
(a) Against spider mites (contact-insecticidal action): bean plants (Phaseolus vulgaris) of about 15 inches height were sprayed drip wet with solutions as prepared above in a concentration as shown below. The bean plants have been infested heavily with the two-spotted spider (species Tetranychus telarius). Evaluation has been carried out after 24 hours, 48 hours and 8 days. -The following results have been obtained:
Aqueous concentration (in Killing rate Compound percent active (in percent) ingredient/ water (I) v e Aqueous concentration (in Killing rate Compound percent active (in percent) ingredient] water (I)--. (I1) O. 001 100 (c) Against caterpillars of the type diamond black moth (Plutella maculipennis): white cabbage has been sprayed drip wet with aqueous emulsions as prepared above in a concentration as shown below. Caterpillars (10 each) have been placed on the sprayed leaves of the white cabbage. The living status has been determined after 24 and 48 hours. The following results have been obtained:
Aqueous concentration (in Killing rate Compound percent; active (in percent) ingredient/ water (I)--. (II) 0.1 100 The following examples are given for the purpose of illustrating the present invention.
3 Example 1 @t l CH2-CH2SCzH CzHgO 47 grams (0.25 mol) of phenyl-ethyl-thiolphosphonite (BJP. 105 C./l mm. Hg.) are dissolved in 50 ml. of anhydrous alcohol. A sodium ethylate solution containing 0.25 mol of dissolved sodium is added thereto while stirring. Subsequently 32 grams of fi-chloroethyl-thioethyl ether are added at 75 C. while stirring is continued. The mixture is further heated to 80 C. for an hour, then cooled to room temperature and the reaction product is poured into 300 ml. of icewater. The precipitated oil is taken up with 200 ml. of benzene, washed with water until neutral and then dried over sodium sulfate. Upon fractionating 41 grams of the new ester of RP. 82 C./ 0.01 mm. Hg are obtained as a water-insoluble colorless oil. Yield: 60% of the theoretical. Caterpillars are killed completely with 0.1% solutions. Systematic action on spider mites with 0.1% solutions=100%.
Calculated for mol 274: S, 23.2%; -P, 11.3%. Found: S, 22.5%; P, 10.86%.
By exactly the same way there may be obtained the following compounds:
P-CHPCH -SCgHg CH3 Example 2 CzHgO 47 grams (0.25 mol) of phenyl-ethyl-thiolphosphonite are dissolved in 50 ml. of anhydrous alcohol. A sodium ethylate solution containing 0.25 mol of dissolved sodium is added thereto at 20 C. Subsequently 28 grams of achloro-methyl-thioethyl ether are added dropwise while stirring is continued. The mixture is heated to 60 C. for an hour and worked up as described in Example '1. 33 grams of the new ester of B.P. 76 C./0.01 mm. Hg are thus obtained as a colorless water-insoluble oil. Yield: 51% of the theoretical. Aphids and spider mites are killed completely with 0.01% solutions. Systemic action on spider mites with 0.1% solutions=100%.
By the same way there may be obtained the compounds of the following formulae:
CgHsO Example 3 CzHaO 47 grams (0.25 mol) of phenyl-ethyl-thiolphosphonite are dissolved in 50 ml. of anhydrous alcohol. A sodium ethylate solution containing 0.25 mol of dissolved sodium is added thereto at 20 ,C. While stirring. Subsequently 46 grams of B-chloro-propionic acid ethyl ester are added dropwise at 50 C. while stirring is continued. The mixbe obtained the following Example 4 CzHsO 47 grams (0.25 mol) of phenyl-ethyl-thiolphosphonite are dissolved in 50 ml. of anhydrous alcohol. A sodium ethylate solution containing 0.25 mol of dissolved sodium is added thereto at 20 C. while stirring. Subsequently 32 grams of chloro-acetic acid ethyl ester are added dropwis'e at 40 C. The mixture is further heated to 60 C. for an hour and then worked up as described in Example 1. 52 grams of the new ester of RP. 78 C./0.0l mm. Hg are thus obtained as a water-insoluble colorless oil. Yield: 76% of the theoretical. Spider mites are killed completely with 0.1% solutions.
Calculated for mol 272: S, 11.8%; P, 11.4%. Found: S, 11.7%; P, 11.3%.
Example 5 47 grams (0.25 mol) of phenyl-ethyl-thiolphosphonite are dissolved in 50 ml. of methanol. A sodium methylate solution containing 0.25 mol of dissolved sodium is added thereto at 20 C. Subsequently 46 grams of OL-bI'OlIlO- propionic acid ethyl ester are added dropwise at 40 C. while stirring is continued. The mixture is heated to 60 C. for another hour and then worked up as described in Example 1. 35 grams of the new ester of BF. 78 C./0.0l mm. Hg are thus obtained as a colorless water-insoluble oil. Yield: 49% of the theoretical.
Calculated for mol 286: S, 11.2%; P, 10.9%. Found: S, 12.1%; P, 11.7%.
I claim:
1. The compound of the following formula 2. The compound of the following formula 3. A compound of the following formula s Rg-SR3 Aryl-i wherein aryl is phenyl, R is a lower alkylene radical having up to 4 carbon atoms, R;, is a lower alkyl radical and R is a lower alkyl radical having up to 4 carbon atoms.
5 a 6 4. A compound of the following formula wherein aryl is lower alkyl-substituted phenyl, R is a s Rg-S-Ra lower alkylene radical having up to 4 carbon atoms, R
is a lower alkyl radical and R is a lower alkyl radical W OR having up to 4 carbon atoms. wherein aryl is chloro-substituted phenyl, R is a lower 5 R fe enc s Cited in the fil f i patent alkylene radical having up to 4 carbon atoms, R;, 1s a Kamai et a1: Zhun Obshchei Khim, 28, 939 941 lower alkyl radical and R is a lower alkyl radical having (1958) cited in Chem Abs 52 17162 (1958) up to 4 carbon atoms. P
udov1k et al.. Bull. Acad. Sci. U.S.S.R. D1v. Chem. 5. A compound of the following formula 10 Sci" English translation, 1952 802F806- fi/Bz-S-Ra Aryl-I

Claims (1)

  1. 3. A COMPOUND OF THE FOLLOWING FORMULA
US44537A 1959-08-21 1960-07-22 Thionophosphinic acid esters and process for their production Expired - Lifetime US3081330A (en)

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DEF29221A DE1115248B (en) 1959-08-21 1959-08-21 Process for the preparation of arylthionophosphinic acid-O-alkyl esters

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BE (1) BE594249A (en)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3376365A (en) * 1964-12-28 1968-04-02 Mobil Oil Corp Phosphinothioate ester

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE23979E (en) * 1948-05-10 1955-04-12 Lubricant composition containing dialkyl
BE568698A (en) 1957-06-24

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* Cited by examiner, † Cited by third party
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3376365A (en) * 1964-12-28 1968-04-02 Mobil Oil Corp Phosphinothioate ester

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BE594249A (en)

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