US2717599A - Needle structure - Google Patents
Needle structure Download PDFInfo
- Publication number
- US2717599A US2717599A US272025A US27202552A US2717599A US 2717599 A US2717599 A US 2717599A US 272025 A US272025 A US 272025A US 27202552 A US27202552 A US 27202552A US 2717599 A US2717599 A US 2717599A
- Authority
- US
- United States
- Prior art keywords
- needle
- point
- cannula
- channel
- outlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3286—Needle tip design, e.g. for improved penetration
Definitions
- This invention relates to improvements in tubular needles and cannulas that are designed to be projected into or through layers of flesh and tissue for hypodermic injection, or to puncture a stopper or other piercea'ble material forming a pharmaceutical closure such .as used in a blood storage vessel.
- the invention has reference to improvements in needles of those kinds having the point forming portion thereof angularly bent relative to the axial line of the cannula and the outlet of the channel opening to the side of the point forming portion.
- reference is directed to that of my U. S. patent issued on October 22, 1946, under No. 2,409,979 wherein the needle point is formed by first beveling the end of the cannula and then bending the point defining portion thereof laterally at such an angle that the beveled surface is brought parallel with ,the axial line of the cannula and flush with the longitudinal side edge of the cannula toward which the point is bent.
- the channel of the cannula is likewise angularly deflected, and the opening therefrom as defined in the flat beveled surface will then open to the side of the point forming portion. If the bending of the point be of any lesser extent than provided for and shown in my above patent, the sharpened top edge of the channel outlet will be unprotected and tissue plug cutting will result when the needle is projected into the flesh.
- Another object of this invention is .to so recess the heel end portion of the outlet of the needle channel that a stylet of substantially the full diameter of the channel can be employed and passed through the [needle channel without causing any outward deflection of the heel defining portion of the needle outlet, this extending of the outlet along the cannulabeing effected in such manner that use of the needle is in no way hindered and tissue or plug cutting thereby is avoided.
- Fig. 1 is an enlarged, side view of a needle embodying the improvements of the present invention therein;
- Figs. 2, 3 and 4 are enlarged longitudinal sectional views of the pointed end portion of a cannula, showing respectively, successive steps taken in the formation of the needle point;
- Fig. 5 is a view of the pointed end portion of the needle as seen from the outlet side of the point and particularly illustrating the recessing of the cannula wall;
- Fig. 6 is an enlarged sectional view of a needle with a point like that of my previously mentioned prior patent, as recessed to permit the easy use therein of a stylet of the full diameter of the channel.
- hypodermic needles are formed with points by beveling the ends of the cannulas at an angle of about twenty degrees relative to their axial lines.
- the channel of each cannula is straight from end to end and the outlet therefrom opens in the axial direction of the needle and from the beveled surface.
- Needles having their points so formed have certain disadvantages, one of which is that of tissue plug cutting.
- the advantages and objects of the present invention reside in the manner of relieving or cutting away the material of the cannula that forms the heel portion across the top edge of the outlet in needles which have the point forming portion angularly bent laterally to any degree that .is lesser than shown in my prior patent.
- a needle embodying the features of the present invention.
- the first operation may consist of cutting off or beveling the end of the cannula 10 at an angle of about 15 degrees relative to its axial line, thus to give it the beveled form shown in Fig. 2.
- the second step in formation of the point has been illustrated in Fig. 3, and it preferably consists in bending the beveled point forming portion laterally, thus causing the channel of the cannula to be similarly bent or angularly deflected and the outlet 11 of the channel, which opens through the beveled surface, to be faced angularly or laterally of the axial line aa of the cannula body.
- This bending of the point forming portion can be to more or lesser degree, but it is now preferred that the piercing end of the beveled portion of the cannula, that is, the extreme point, as herein designated by numeral 12, be brought approximately to the axial line of the cannula.
- the needle may be used in the form shown in Fig. 3 and due to the fact that the beveled surface is substantially flat, having a cutting edge defining its sides, and also due to the fact that it inclines towards the extended axial line of the cannula body at a relatively small angle, plugging is substantially eliminated.
- the bend of the point starts at a location, designated at 14, that is substantially opposite the top or heel forming ,p'ortion about the channel outlet. This rather abrupt bending of the cannula, notedbest in Figs.
- a stylet is designated at .numeral 15 and the hindrance to its being projected through the channel by As a consequence of such hindrance, a stylet of substantially lesser diameter than the channel must be used, but use of such has its objections and disadvantages.
- the top edge of the outlet is, in this specific form of needle, unprotected by the extending point forming portion of the needle, the rounding off of this edge is of such character that its exposure is not objectionable, nor is it a hindrance to use of the needle.
- a stylet 15 of full size can be passed through the channel; this being due to the fact that a sufficient length of stylet passes beyond the base of the recess before its end engages the curve or bend of the needle point forming wall. Accordingly it can bend in conformity with the angular surface of the needle point as has been indicated in Fig. 4.
- the present needle as shown in Figs. 1 and 4 has no tendency to be deflected laterally when pressed through a stopper or pharmaceutical closure, this being due to the fact that the point is substantially in the axial line of the needle and the beveled side surface and the back wall surface of the point are substantially at the same degree relative to the axial line of the cannula, as shown in Fig. 4.
- the relieving or recessing of the heel shall be to any definite extent, but shall be governed by the requirements of the particular needle and results desired to be accomplished.
- a needle structure comprising a cannula body with an angular bend near its end and a substantially flat inclined surface extending across the bent portion and having cutting edges defining its sides, said surface starting substantially at the start of the bend, at the inside of the angle, and inclined toward the extended axial line of the cannula body.
- a needle structure comprising a cannula body with an angular bend near its end, and a substantially flat inclined surface extending across the bent portion and having cutting edges defining its sides, said surface extending from a point substantially at the start of the bend at the inside of the angle and inclined toward the extended axial line of the cannula body at an angle approximately equal to that at which the cannula body is bent.
- a needle structure comprising a tubular cannula body with an angular bend near its end, and a substantially flat inclined surface extending obliquely across the bent portion and having cutting edges defining its sides, said surface continuing from a point substantially at the start of the bend at the inside of the angle and inclined toward the extended axial line of the cannula body; the channel of the cannula opening through said surface and having the heel portion of its bounding edge relieved to cause bluntness of the edge.
- a needle structure comprising a tubular cannula body with an angular bend near its end, and an inclined surface extending obliquely across the bent portion, from a point that is substantially at the start of the bend at the inside of the angle and inclined toward the extended axial line of the cannula body; the channel of the cannula opening through said surface and there being a recess formed in the tubular body extending from the top edge of the outlet of the channel, away from the point.
- a hypodermic needle and stylet combination comprising a cannula formed near its end with an angular bend and having a beveled surface extending obliquely across the bent portion from the start of the bend, at the inside thereof, toward the extended axial line of the cannula body and containing the outlet of the channel of the cannula therein, and there being a recess formed in the cannula wall, extending from the top edge of the channel outlet as defined in said beveled surface, to a substantial distance along the channel, and formed to the full diameter of the channel; said stylet being of substantially the full diameter of the channel and extended through the channel and from the outlet.
- a hypodermic needle comprising a cannula formed near its end with an angular bend and having a beveled surface extending obliquely across the bent portion from the start of the bend, at the inside thereof, toward the extended axial line of the cannula body and containing the outlet of the channel of the cannula therein, and there being a recess formed in the cannula wall, extending from the top edge of the channel outlet as defined in said beveled surface, to a substantial distance along the channel, and formed to the full diameter of the channel; and having its bounding edges rounded to avoid tissue cutting when projected into the flesh.
- a hypodermic needle including a cannula body having an angularly extending end portion having sharpened side edges and being flat throughout its major surface, said end portion terminating in a piercing point lying substantially in line with the axis of said body, the cannula bore being exposed through a zone beginning short of said point and continuing through to a body edge located adjacent a line short of that at which the angularity of said end portion is initiated and said edge being rounded in the direction of said point.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US272025A US2717599A (en) | 1952-02-18 | 1952-02-18 | Needle structure |
FR1070729D FR1070729A (fr) | 1952-02-18 | 1953-02-10 | Aiguille hypodermique |
US471665A US2717600A (en) | 1952-02-18 | 1954-11-24 | Needle structure |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US272025A US2717599A (en) | 1952-02-18 | 1952-02-18 | Needle structure |
FR1070729T | 1953-02-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
US2717599A true US2717599A (en) | 1955-09-13 |
Family
ID=32095153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US272025A Expired - Lifetime US2717599A (en) | 1952-02-18 | 1952-02-18 | Needle structure |
Country Status (2)
Country | Link |
---|---|
US (1) | US2717599A (fr) |
FR (1) | FR1070729A (fr) |
Cited By (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2746454A (en) * | 1953-05-04 | 1956-05-22 | Hans W Sorensen | Intravenous needle |
US2904045A (en) * | 1958-04-14 | 1959-09-15 | Owings Thomas | Hypodermic needles |
US3064651A (en) * | 1959-05-26 | 1962-11-20 | Henderson Edward | Hypodermic needle |
US4889529A (en) * | 1987-07-10 | 1989-12-26 | B. Braun Melsungen Ag | Needle |
DE3915215A1 (de) * | 1989-05-05 | 1990-11-08 | Moehring Klaus | Geraet zum einfuehren langgestreckter gegenstaende in menschliche oder tierische koerperhoehlen oder organe |
DE4101231A1 (de) * | 1991-01-17 | 1992-07-23 | Fresenius Ag | Kanuele |
DE4109864A1 (de) * | 1991-03-26 | 1992-10-08 | Johann Dr Med Rull | Stanzfreie, -lose injektionskanuelen in medizinischem und industriellem bereich |
US5515871A (en) * | 1990-09-28 | 1996-05-14 | Sulzer Brothers Ltd. | Hollow needle for medical use and a laser method for manufacturing |
DE19512607A1 (de) * | 1995-04-04 | 1996-10-10 | Johann Dr Med Rull | Völlig tragmentationsfreie Kanülen |
US20020106813A1 (en) * | 2001-01-26 | 2002-08-08 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US20020110493A1 (en) * | 1998-08-13 | 2002-08-15 | Symyx Technologies , Inc | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6443929B1 (en) | 1996-02-27 | 2002-09-03 | Injectimed, Inc. | Needle tip guard for hypodermic needles |
US6500157B2 (en) * | 1998-09-03 | 2002-12-31 | Ronald B. Luther | Intravenous infusion needle with soft body |
US6629959B2 (en) | 1996-02-27 | 2003-10-07 | Injectimed, Inc. | Needle tip guard for percutaneous entry needles |
US6802199B2 (en) | 1999-02-04 | 2004-10-12 | Integ, Inc. | Needle for body fluid tester |
US20040241875A1 (en) * | 2001-01-26 | 2004-12-02 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US20050215977A1 (en) * | 2004-03-25 | 2005-09-29 | Uschold John E | Needles and methods of using same |
US20060178646A1 (en) * | 2005-02-04 | 2006-08-10 | Chad Harris | Non-coring needles and methods of manufacturing same |
US20070123935A1 (en) * | 2005-11-30 | 2007-05-31 | Myers Gene E | Method and apparatus for contemporaneous formation of a body structure opening and homologous pedicle |
US20070293873A1 (en) * | 2006-06-19 | 2007-12-20 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US20080097335A1 (en) * | 2006-08-04 | 2008-04-24 | Allergan, Inc. | Ocular implant delivery assemblies |
US20090264813A1 (en) * | 2006-06-19 | 2009-10-22 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US20100185205A1 (en) * | 2009-01-16 | 2010-07-22 | Allergan, Inc. | Interocular injector |
US7867215B2 (en) | 2002-04-17 | 2011-01-11 | Carmel Pharma Ab | Method and device for fluid transfer in an infusion system |
USD637713S1 (en) | 2009-11-20 | 2011-05-10 | Carmel Pharma Ab | Medical device adaptor |
US7942860B2 (en) | 2007-03-16 | 2011-05-17 | Carmel Pharma Ab | Piercing member protection device |
US7975733B2 (en) | 2007-05-08 | 2011-07-12 | Carmel Pharma Ab | Fluid transfer device |
US8029747B2 (en) | 2007-06-13 | 2011-10-04 | Carmel Pharma Ab | Pressure equalizing device, receptacle and method |
US8075550B2 (en) | 2008-07-01 | 2011-12-13 | Carmel Pharma Ab | Piercing member protection device |
US8162013B2 (en) | 2010-05-21 | 2012-04-24 | Tobias Rosenquist | Connectors for fluid containers |
US8273056B2 (en) | 2011-02-28 | 2012-09-25 | Injectimed, Inc. | Needle guard with resilient spring surrounding tip shield |
US8287513B2 (en) | 2007-09-11 | 2012-10-16 | Carmel Pharma Ab | Piercing member protection device |
US8328772B2 (en) * | 2003-01-21 | 2012-12-11 | Carmel Pharma Ab | Needle for penetrating a membrane |
US8414539B1 (en) | 2011-12-27 | 2013-04-09 | B. Braun Melsungen Ag | Needle tip guard for percutaneous entry needles |
US20130116556A1 (en) * | 2011-11-05 | 2013-05-09 | Custom Medical Applications | Neural safety injection system and related methods |
US8480646B2 (en) | 2009-11-20 | 2013-07-09 | Carmel Pharma Ab | Medical device connector |
WO2013104642A1 (fr) * | 2012-01-09 | 2013-07-18 | Fresenius Kabi Deutschland Gmbh | Canule pour chambre implantable permettant de piquer des cathéters à chambre implantable |
US8523838B2 (en) | 2008-12-15 | 2013-09-03 | Carmel Pharma Ab | Connector device |
US8545475B2 (en) | 2002-07-09 | 2013-10-01 | Carmel Pharma Ab | Coupling component for transmitting medical substances |
US8562583B2 (en) | 2002-03-26 | 2013-10-22 | Carmel Pharma Ab | Method and assembly for fluid transfer and drug containment in an infusion system |
US8622985B2 (en) | 2007-06-13 | 2014-01-07 | Carmel Pharma Ab | Arrangement for use with a medical device |
US8657803B2 (en) | 2007-06-13 | 2014-02-25 | Carmel Pharma Ab | Device for providing fluid to a receptacle |
US8672895B2 (en) | 2011-02-28 | 2014-03-18 | Injectimed, Inc. | Needle guard |
EP2711080A1 (fr) * | 2012-09-24 | 2014-03-26 | Siemens Healthcare Diagnostics Products GmbH | Aiguille creuse pour pipette de prélèvement |
US8790330B2 (en) | 2008-12-15 | 2014-07-29 | Carmel Pharma Ab | Connection arrangement and method for connecting a medical device to the improved connection arrangement |
US8827978B2 (en) | 2007-09-17 | 2014-09-09 | Carmel Pharma Ab | Bag connector |
CN104721911A (zh) * | 2015-03-05 | 2015-06-24 | 倪治法 | 无损伤防脱落穿刺针 |
US9168203B2 (en) | 2010-05-21 | 2015-10-27 | Carmel Pharma Ab | Connectors for fluid containers |
US20160338628A1 (en) * | 2015-05-22 | 2016-11-24 | Dexcom, Inc. | Needle for transcutaneous analyte sensor delivery |
US20170119974A1 (en) * | 2015-11-04 | 2017-05-04 | Custom Medical Applications, Inc. | Needles and related assemblies and methods |
US9668725B2 (en) | 2015-03-24 | 2017-06-06 | Richard B. Beaven | Laparoscopic wound closure device |
US10398834B2 (en) | 2007-08-30 | 2019-09-03 | Carmel Pharma Ab | Device, sealing member and fluid container |
CN110354334A (zh) * | 2019-07-24 | 2019-10-22 | 河南曙光汇知康生物科技股份有限公司 | 输液港用穿刺针针头及其制成的输液港用穿刺针 |
WO2021204606A1 (fr) | 2020-04-08 | 2021-10-14 | Carl Zeiss Meditec Ag | Injecteur de lentille intraoculaire ayant une pointe d'insertion spécifique d'une aiguille creuse |
US20220081178A1 (en) * | 2012-10-19 | 2022-03-17 | Cryovac, Llc | Apparatus and method for vacuum skin packaging of a product |
WO2022063573A1 (fr) * | 2020-09-25 | 2022-03-31 | Carl Zeiss Meditec Ag | Piston pour un injecteur et injecteur |
WO2022097111A1 (fr) * | 2020-11-09 | 2022-05-12 | Upstream Peripheral Technologies Ltd. | Aiguille non perforante à bord tranchant inversé |
USD979746S1 (en) | 2021-02-26 | 2023-02-28 | Luther Needlesafe Products, Llc | Over-the-needle catheter insertion device |
US11752306B2 (en) | 2021-01-22 | 2023-09-12 | Luther Needlesafe Products, Llc | Low profile passive protector for an I.V. catheter |
US11951265B2 (en) | 2022-08-08 | 2024-04-09 | Embrace Medical Ltd | Vascular access wire tip comprising a crank |
WO2024132868A1 (fr) * | 2022-12-19 | 2024-06-27 | Stichting Radboud Universitair Medisch Centrum | Aiguille de positionnement |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2481930A1 (fr) * | 1980-05-06 | 1981-11-13 | Villette Alain | Aiguille a injection perforante non obstruable |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR577367A (fr) * | 1923-04-13 | 1924-09-04 | Perfectionnements aux aiguilles pour injections | |
GB620780A (en) * | 1945-11-05 | 1949-03-30 | Menthen Willem | Improvements in and relating to hypodermic syringe needles |
FR965711A (fr) * | 1950-09-20 | |||
US2562129A (en) * | 1946-01-23 | 1951-07-24 | Scherer Corp R P | Hypodermic syringe |
-
1952
- 1952-02-18 US US272025A patent/US2717599A/en not_active Expired - Lifetime
-
1953
- 1953-02-10 FR FR1070729D patent/FR1070729A/fr not_active Expired
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR965711A (fr) * | 1950-09-20 | |||
FR577367A (fr) * | 1923-04-13 | 1924-09-04 | Perfectionnements aux aiguilles pour injections | |
GB620780A (en) * | 1945-11-05 | 1949-03-30 | Menthen Willem | Improvements in and relating to hypodermic syringe needles |
US2562129A (en) * | 1946-01-23 | 1951-07-24 | Scherer Corp R P | Hypodermic syringe |
Cited By (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2746454A (en) * | 1953-05-04 | 1956-05-22 | Hans W Sorensen | Intravenous needle |
US2904045A (en) * | 1958-04-14 | 1959-09-15 | Owings Thomas | Hypodermic needles |
US3064651A (en) * | 1959-05-26 | 1962-11-20 | Henderson Edward | Hypodermic needle |
US4889529A (en) * | 1987-07-10 | 1989-12-26 | B. Braun Melsungen Ag | Needle |
DE3915215A1 (de) * | 1989-05-05 | 1990-11-08 | Moehring Klaus | Geraet zum einfuehren langgestreckter gegenstaende in menschliche oder tierische koerperhoehlen oder organe |
US5403296A (en) * | 1989-05-05 | 1995-04-04 | Mohring; Klaus | Puncturing instrument |
US5515871A (en) * | 1990-09-28 | 1996-05-14 | Sulzer Brothers Ltd. | Hollow needle for medical use and a laser method for manufacturing |
DE4101231A1 (de) * | 1991-01-17 | 1992-07-23 | Fresenius Ag | Kanuele |
DE4109864A1 (de) * | 1991-03-26 | 1992-10-08 | Johann Dr Med Rull | Stanzfreie, -lose injektionskanuelen in medizinischem und industriellem bereich |
DE19512607A1 (de) * | 1995-04-04 | 1996-10-10 | Johann Dr Med Rull | Völlig tragmentationsfreie Kanülen |
US7927314B2 (en) | 1996-02-27 | 2011-04-19 | B. Bran Melsungen AG | Needle tip guard for percutaneous entry needles |
US6443929B1 (en) | 1996-02-27 | 2002-09-03 | Injectimed, Inc. | Needle tip guard for hypodermic needles |
US6629959B2 (en) | 1996-02-27 | 2003-10-07 | Injectimed, Inc. | Needle tip guard for percutaneous entry needles |
US7534231B2 (en) | 1996-02-27 | 2009-05-19 | Injectimed, Inc. | Needle tip guard for percutaneous entry needles |
US8444605B2 (en) | 1996-02-27 | 2013-05-21 | B. Braun Melsungen Ag | Needle tip guard for percutaneous entry needles |
US8545454B2 (en) | 1996-02-27 | 2013-10-01 | B. Braun Melsungen Ag | Needle tip guard for percutaneous entry needles |
US20060189934A1 (en) * | 1996-02-27 | 2006-08-24 | Kuracina Thomas C | Needle tip guard for percutaneous entry needles |
US20020110493A1 (en) * | 1998-08-13 | 2002-08-15 | Symyx Technologies , Inc | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6913934B2 (en) * | 1998-08-13 | 2005-07-05 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6500157B2 (en) * | 1998-09-03 | 2002-12-31 | Ronald B. Luther | Intravenous infusion needle with soft body |
US6863662B2 (en) | 1998-09-03 | 2005-03-08 | Ronald B. Luther | Intravenous infusion needle with soft body |
US6802199B2 (en) | 1999-02-04 | 2004-10-12 | Integ, Inc. | Needle for body fluid tester |
US20040236249A1 (en) * | 1999-02-04 | 2004-11-25 | Hilgers Michael Edward | Needle for body fluid tester |
US20040241875A1 (en) * | 2001-01-26 | 2004-12-02 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US7335513B2 (en) | 2001-01-26 | 2008-02-26 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US20080138260A1 (en) * | 2001-01-26 | 2008-06-12 | Symyx Technologies, Inc | Apparatus and methods for parallel processing of multiple reaction mixtures |
US20020106813A1 (en) * | 2001-01-26 | 2002-08-08 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US7858049B2 (en) | 2001-01-26 | 2010-12-28 | Freeslate, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6860871B2 (en) | 2001-04-30 | 2005-03-01 | Injectimed, Inc. | Needle tip guard for percutaneous entry needles |
US20030195479A1 (en) * | 2001-04-30 | 2003-10-16 | Kuracina Thomas C. | Needle tip guard for percutaneous entry needles |
US8562583B2 (en) | 2002-03-26 | 2013-10-22 | Carmel Pharma Ab | Method and assembly for fluid transfer and drug containment in an infusion system |
US10123938B2 (en) | 2002-03-26 | 2018-11-13 | Carmel Pharma Ab | Method and assembly for fluid transfer and drug containment in an infusion system |
US10806668B2 (en) | 2002-03-26 | 2020-10-20 | Carmel Pharma Ab | Method and assembly for fluid transfer and drug containment in an infusion system |
US7867215B2 (en) | 2002-04-17 | 2011-01-11 | Carmel Pharma Ab | Method and device for fluid transfer in an infusion system |
US8545475B2 (en) | 2002-07-09 | 2013-10-01 | Carmel Pharma Ab | Coupling component for transmitting medical substances |
US9039672B2 (en) | 2002-07-09 | 2015-05-26 | Carmel Pharma Ab | Coupling component for transmitting medical substances |
US8328772B2 (en) * | 2003-01-21 | 2012-12-11 | Carmel Pharma Ab | Needle for penetrating a membrane |
US20050215977A1 (en) * | 2004-03-25 | 2005-09-29 | Uschold John E | Needles and methods of using same |
US7645268B2 (en) * | 2004-03-25 | 2010-01-12 | Boston Scientific Scimed, Inc. | Needles and methods of using same |
US7651482B2 (en) * | 2005-02-04 | 2010-01-26 | Boston Scientific Scimed, Inc. | Non-coring needles and methods of manufacturing same |
US20060178646A1 (en) * | 2005-02-04 | 2006-08-10 | Chad Harris | Non-coring needles and methods of manufacturing same |
US20070123935A1 (en) * | 2005-11-30 | 2007-05-31 | Myers Gene E | Method and apparatus for contemporaneous formation of a body structure opening and homologous pedicle |
US20090264813A1 (en) * | 2006-06-19 | 2009-10-22 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US8668676B2 (en) * | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US20070293873A1 (en) * | 2006-06-19 | 2007-12-20 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US20080097335A1 (en) * | 2006-08-04 | 2008-04-24 | Allergan, Inc. | Ocular implant delivery assemblies |
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