US2278339A - Test strip - Google Patents

Test strip Download PDF

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Publication number
US2278339A
US2278339A US316310A US31631040A US2278339A US 2278339 A US2278339 A US 2278339A US 316310 A US316310 A US 316310A US 31631040 A US31631040 A US 31631040A US 2278339 A US2278339 A US 2278339A
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United States
Prior art keywords
tuberculin
patches
patch
strip
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US316310A
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English (en)
Inventor
Vollmer Hermann
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Individual
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Individual
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Filing date
Publication date
Priority to NL64817D priority Critical patent/NL64817C/xx
Application filed by Individual filed Critical Individual
Priority to US316310A priority patent/US2278339A/en
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Publication of US2278339A publication Critical patent/US2278339A/en
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0035—Vaccination diagnosis other than by injuring the skin, e.g. allergy test patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0006—Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Definitions

  • This invention relates to patch test strips for human beings and is more particularly directed to patch test strips to determine relative skin sensitivity of individuals exhibiting positive reaction.
  • Fig. 1 represents a plan view of one of my patch test strips
  • Fig. 2 shows in elevation and somewhat diagrammatically a human limb to which my patch test strip has been applied and removed with the skin reactions indicated;
  • Fig. 3 is a perspective of an enlarged portion of a patch test strip; and Fig. 4 is a segmental plan view of a modified patch test strip.
  • the patch test strip comprises a base I of any suitable adhesive strip. Adhering to the adhesive side of the strip are spaced patches 2, 3, 4, 5 and 6 made up of squares of a fine-grained highly absorbent material presenting a substantially continuous exposed surface, e. g. filter paper. As shown in greater detail in Fig. 3 a patch test strip may comprise a cloth or other suitable base 1 carrying an adhesive layer 8 on one face thereof.
  • sheets of the absorbent material are saturated with solutions oftuberculin.
  • I may use old tuberculin from synthetic media which may or may not contain the ground bodies of the tubercle bacilli.
  • the filter paper or other suitable absorbent material is thoroughly air-dried in a suitable dustless cham-.
  • the sheets When the sheets are dry, they are cut into patches or squares about 1 cm. square and are then applied'by means of forceps or the like to the adhesive face of the strip.
  • the patches are spaced at least 1 cm. apart. It will be apparent that the strips and patches may be of any desired practical length, shape and size as required for any particular use.
  • the patches which are used contain gradually decreasing tuberculin concentrations.
  • patch 2 may contain full strength tuberculin.
  • Patches 3, i, 5 and 6 may contain, respectively, /4, ,4 and 0 strength tuberculin.
  • I first prefer to clean the skin to which the strip is to be applied, with a material such as ether.
  • a material such as ether.
  • I apply the adhesive side of the sternum or transversely over the upper edge of the trapezius or at any other suitable place on the body.
  • the strip is allowed to remain about forty-eight hours and is then removed. While the results of the test may be read immediately after removal of the strip, it is preferable to read the reaction after about twenty-four to fortyeight hours after removal of the strip in order to permit fading out of any unspecific skin redness and also since the additional time permits intensification oi the tuberculin reaction. Where a positive reaction is obtained, there appear squares of clearly defined redness with acorn-like follicular elevations.
  • Fig. 2 shows a characteristic positive reaction
  • the limb is designated by 9.
  • Square I2 represents a reaction to full strength tuberculin.
  • Square 43 represents a reaction to Square I4 shows a reaction to-Ai strength strength tuberculin.
  • tuberculin and square I5 shows a reaction to 0 strength tuberculin.
  • the patch containing Vino strength tuberculin gave a negative reaction.
  • the degree of,reaction obtained is a function of the concentration of tuberculin applied and the clinical results obtained in practice have borne this out.
  • the patches may be of any desired shape or. size.
  • Fig. 4 there is illustrated a convenient modification of the patch made in the form of a cross. These patches are designated as l6 and I1. For comparative purposes the dimensions of the cross patch are modified so that the area of this patch is approximately 1 square cm.
  • the cross patches in the case of positive reactions, will give a clearly defined skin redness corresponding generally with the shape of the patch.
  • the strips may be stored for long periods of time without deterioration.
  • the adhesive side carrying the patches may be covered with stiff gauze. Prior to use, the gauze is stripped from the adhesive surface and the test strip is to the immediate vicinity of the patch. The ab- :1.
  • My patch strips are also useful in tuberculin therapy since the strip containing several patches with gradually increasing concentrations of tutuberculin.
  • tuberculin solution used for the saturation of the test patches except that the control contains no tuberculin.
  • the tuberculin solution used for impregnating the patches may be of any suitable type.
  • I may use the tuberculin prepared in a growing medium containing glycerine and broth or glycerinc and some synthetic growing medium.' This type tuberculin is customarily referred to as old I may also use crystalline or pure tuberculin obtained from any suitable source but in this case the aqueous tuberculin solution is prepared -and glycerine should be added since small amounts of glycerine in the tuberculin are necessary for best results.
  • the patches are prepared as previously described and are dried so as to obtain the dry tuberculin. The dry patches adhere dirtectly to the adhesive surface of the adhesive s rip.
  • I may also utilize 1 sorbent material adhering to the adhesive face berculin may be applied to the skin to permit the tuberculin to be absorbed very slowly and in gradually increasing amounts through the skin.
  • the accurate control of area and dosage permitted by the patch strips is such as to avoid dangerous reactions while permitting rapid, economical and technically simple procedure.
  • the tuberculin patch therapy apparently relies for its results upon desensitization.
  • the patches used should be of a highly absorbent material sufficiently strong in thin patches to permit handling and of such a nature as to present a substantially continuous surface to the skin.
  • thin filter paper exceptionally well suited for this purpose although I may use other thin absorbent materials such as certain types of thin and closely woven cloth, e. g. finely textured cotton, linen or silk having physical properties similar to the filter paper.
  • a single layer of such a patch is suificien't.
  • control patches While the use of control patches is not necessary, there may be some instances in which the use thereof is desirable as a check and in such cases I may apply to the patch test strip one or more patches of the same absorbent material except that th control patches are saturated only with glycerine-bouillon.
  • the glycerine-bouillon of said strip, and tuberculin substantially evenly absorbed by each of said patches in such amounts that said patches contain tuberculin in various concentrations thereby enabling by one single test quantitative determination of the sensitivity of the skin to tuberculin.
  • Allergometric patch test strip comprising .a length of adhesive material, a series of filter paper patches directly adhering to the adhesive face of said adhesive material, and tuberculin substance substantially evenly absorbed by said patches in such a manner that the amount of the tuberculin substance carried by one of said patches is differing from the amounts carried by the other patches, thereby enabling with one single test quantitative determination of the sensitivity of the skin to tuberculin.
  • Allergometric patch test strip comprising a length of adhesive material, a series of patches of thin filter paper directly adhering to the adhesive face of said adhesive material, tuberculin sub-stance absorbed by said thin filter paper patches in such a way that each of said patches is carrying a different amount of said dry tuberculin substance varying in the ratio of about 1:1/2:1/4:1/20:l/100 per unit of exposed surface, thereby enabling by one single test quantitative determination of the sensitivity of the skin to tuberculin.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicinal Preparation (AREA)
US316310A 1940-01-30 1940-01-30 Test strip Expired - Lifetime US2278339A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NL64817D NL64817C (enrdf_load_stackoverflow) 1940-01-30
US316310A US2278339A (en) 1940-01-30 1940-01-30 Test strip

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US316310A US2278339A (en) 1940-01-30 1940-01-30 Test strip

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US2278339A true US2278339A (en) 1942-03-31

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NL (1) NL64817C (enrdf_load_stackoverflow)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2422866A (en) * 1945-03-09 1947-06-24 Vollmer Hermann Diagnostic preparations
US2553552A (en) * 1946-11-08 1951-05-22 Nat Jewish Hospital Tuberculosis diagnostic composition
US2793954A (en) * 1955-03-18 1957-05-28 Clarice E Nelson Tea bag construction
US3094373A (en) * 1961-12-04 1963-06-18 Louis F Luechauer Tester for laundry process and laundry process employing the same
US3319621A (en) * 1963-12-18 1967-05-16 Schwerin Res Corp Salivation testing methods and devices
US3703890A (en) * 1970-08-10 1972-11-28 Milton A Saunders Jr Skin patch test device
WO1983001308A1 (en) * 1981-10-05 1983-04-14 Mast Medical Ind Ltd Allergy screening system and method of making and using same
EP0123539A3 (en) * 1983-04-21 1987-09-09 James Chester Breneman Immune responses to ingestible substances
US4818707A (en) * 1983-04-21 1989-04-04 Breneman James C Device and mixture for testing for immune responses to food
US4968604A (en) * 1989-07-20 1990-11-06 Neorx Corporation Method and test kit for detection of antibodies
US5075077A (en) * 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
EP1932480A1 (en) * 2006-12-15 2008-06-18 Bio Optica-Milano S.p.A. Support element for biopsy and kit for collecting and treating biopsies comprising this support
USD995337S1 (en) * 2021-06-14 2023-08-15 Derek Kalev Toomre Multi-odorant testing device

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2422866A (en) * 1945-03-09 1947-06-24 Vollmer Hermann Diagnostic preparations
US2553552A (en) * 1946-11-08 1951-05-22 Nat Jewish Hospital Tuberculosis diagnostic composition
US2793954A (en) * 1955-03-18 1957-05-28 Clarice E Nelson Tea bag construction
US3094373A (en) * 1961-12-04 1963-06-18 Louis F Luechauer Tester for laundry process and laundry process employing the same
US3319621A (en) * 1963-12-18 1967-05-16 Schwerin Res Corp Salivation testing methods and devices
US3703890A (en) * 1970-08-10 1972-11-28 Milton A Saunders Jr Skin patch test device
WO1983001308A1 (en) * 1981-10-05 1983-04-14 Mast Medical Ind Ltd Allergy screening system and method of making and using same
US4459360A (en) * 1981-10-05 1984-07-10 Mast Medical Industries, Ltd. Multiple-component binding assay system and method of making and using it
EP0123539A3 (en) * 1983-04-21 1987-09-09 James Chester Breneman Immune responses to ingestible substances
US4818707A (en) * 1983-04-21 1989-04-04 Breneman James C Device and mixture for testing for immune responses to food
US5075077A (en) * 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
US4968604A (en) * 1989-07-20 1990-11-06 Neorx Corporation Method and test kit for detection of antibodies
EP1932480A1 (en) * 2006-12-15 2008-06-18 Bio Optica-Milano S.p.A. Support element for biopsy and kit for collecting and treating biopsies comprising this support
USD995337S1 (en) * 2021-06-14 2023-08-15 Derek Kalev Toomre Multi-odorant testing device

Also Published As

Publication number Publication date
NL64817C (enrdf_load_stackoverflow)

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