GB1075743A - Diagnostic test pack - Google Patents
Diagnostic test packInfo
- Publication number
- GB1075743A GB1075743A GB34177/64A GB3417764A GB1075743A GB 1075743 A GB1075743 A GB 1075743A GB 34177/64 A GB34177/64 A GB 34177/64A GB 3417764 A GB3417764 A GB 3417764A GB 1075743 A GB1075743 A GB 1075743A
- Authority
- GB
- United Kingdom
- Prior art keywords
- serum
- tested
- diagnostic test
- allowed
- spots
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002405 diagnostic procedure Methods 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 210000002966 serum Anatomy 0.000 abstract 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 239000001913 cellulose Substances 0.000 abstract 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- 201000011252 Phenylketonuria Diseases 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 230000002745 absorbent Effects 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 230000001174 ascending effect Effects 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000003365 glass fiber Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 229920000915 polyvinyl chloride Polymers 0.000 abstract 1
- 239000004800 polyvinyl chloride Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
- G01N30/94—Development
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/64—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
A diagnostic test pack for determining phenylalanine in blood (e.g. for detection of phenylketonuria) comprises an absorbent carrier strip to which serum to be tested may be applied and a developer comprising 0.3-1.0% ninhydrin dissolved in the separated upper layer formed when butanol and aqueous acetic acid are mixed and allowed to stand. The carrier is preferably paper, but any bibulous material, e.g. made of cellulose, modified cellulose, polyvinyl chloride, or glass fibres may be used. In use, a serum containing a known amount of alanine is preferably spotted, with the serum to be tested, on the test strip, the sera allowed to dry, and the spots developed by ascending, descending, circular, disc or radial chromatography. After development and drying, the colour intensity of the furthest advanced spots, is compared.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US367250A US3399971A (en) | 1964-05-13 | 1964-05-13 | Medical diagnostic method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1075743A true GB1075743A (en) | 1967-07-12 |
Family
ID=23446457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB34177/64A Expired GB1075743A (en) | 1964-05-13 | 1964-08-20 | Diagnostic test pack |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US3399971A (en) |
| GB (1) | GB1075743A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009006131A1 (en) * | 2007-06-29 | 2009-01-08 | 3M Innovative Properties Company | An indicating fiber |
| US8329851B2 (en) | 2007-06-29 | 2012-12-11 | 3M Innovative Properties Company | Functional polymer with a pendant color changing indicator |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1598807A1 (en) * | 1966-07-16 | 1971-01-07 | Merck Patent Gmbh | Method and means for the early diagnosis of phenylketonuria, maple syrup disease and hypervalinaemia |
| US4274833A (en) * | 1979-10-18 | 1981-06-23 | Pickering Michael V | Ninhydrin reagent for use in amine and amino acid analyses |
| US6461329B1 (en) * | 2000-03-13 | 2002-10-08 | Medtronic Minimed, Inc. | Infusion site leak detection system and method of using the same |
| US7641612B1 (en) | 2006-01-17 | 2010-01-05 | Mccall Kenneth Shawn | Blood loss detection for hemodialysis system |
| CN110441524A (en) * | 2019-07-22 | 2019-11-12 | 浙江大学 | Detect application of the antibody of phenylketonuria marker in preparation diagnosis test paper |
-
1964
- 1964-05-13 US US367250A patent/US3399971A/en not_active Expired - Lifetime
- 1964-08-20 GB GB34177/64A patent/GB1075743A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009006131A1 (en) * | 2007-06-29 | 2009-01-08 | 3M Innovative Properties Company | An indicating fiber |
| US8329851B2 (en) | 2007-06-29 | 2012-12-11 | 3M Innovative Properties Company | Functional polymer with a pendant color changing indicator |
Also Published As
| Publication number | Publication date |
|---|---|
| US3399971A (en) | 1968-09-03 |
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