US2060228A - Soap - Google Patents
Soap Download PDFInfo
- Publication number
- US2060228A US2060228A US545367A US54536731A US2060228A US 2060228 A US2060228 A US 2060228A US 545367 A US545367 A US 545367A US 54536731 A US54536731 A US 54536731A US 2060228 A US2060228 A US 2060228A
- Authority
- US
- United States
- Prior art keywords
- soap
- irradiated
- sterol
- rachitic
- properties
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000344 soap Substances 0.000 title description 49
- 229930182558 Sterol Natural products 0.000 description 28
- 150000003432 sterols Chemical class 0.000 description 28
- 235000003702 sterols Nutrition 0.000 description 28
- 230000001749 antrachitic effect Effects 0.000 description 20
- 230000009286 beneficial effect Effects 0.000 description 12
- 239000000203 mixture Substances 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 241000282414 Homo sapiens Species 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 4
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 4
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 4
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 208000007442 rickets Diseases 0.000 description 3
- 241000700159 Rattus Species 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- ARXHRTZAVQOQEU-UHFFFAOYSA-N (10R)-3c,5t,6t-Trihydroxy-10r,13c-dimethyl-17c-((1R:4R)-1,4,5-trimethyl-hexen-(2t)-yl)-(9tH,14tH)-Delta7-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(C)C(C)C)CCC33)C)C3=CC(O)C21O ARXHRTZAVQOQEU-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- UJELMAYUQSGICC-UHFFFAOYSA-N Zymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(C)C=CCC(C)C)CCC21 UJELMAYUQSGICC-UHFFFAOYSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- ARXHRTZAVQOQEU-BRVLHLJYSA-N cerevisterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)/C=C/[C@H](C)C(C)C)CC[C@H]33)C)C3=C[C@@H](O)[C@]21O ARXHRTZAVQOQEU-BRVLHLJYSA-N 0.000 description 1
- ARXHRTZAVQOQEU-SXOCEXOESA-N cerevisterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@@H]2C3=C[C@H](O)[C@@]4(O)C[C@@H](O)CC[C@@]4(C)[C@@H]3CC[C@]12C ARXHRTZAVQOQEU-SXOCEXOESA-N 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- -1 phytosterol Chemical compound 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- CGSJXLIKVBJVRY-XTGBIJOFSA-N zymosterol Chemical compound C([C@@]12C)C[C@H](O)C[C@@H]1CCC1=C2CC[C@]2(C)[C@@H]([C@@H](CCC=C(C)C)C)CC[C@H]21 CGSJXLIKVBJVRY-XTGBIJOFSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
Definitions
- This invention relates to a soap having an antirachitic, factor incorporated therein and to a method for its preparation, and 'more particularly to a soap having beneficial dermatological properties because of the incorporation therein of a sterol containing the antirachitic property.
- irradiated sterols and substances containing sterols that have been irradiated with ultraviolet or other rays to impart to such sterols an anti-rachitic property have a beneficial effect when applied to the human skin, or when oils and fats capable of being absorbed by the skin and containing such irradiated sterols are employed in the manufacture of a soap and the soap then used in the 30 usual manner with water for hygienic purposes.
- the soap obviously, must be one that is compatible with the irradiated or activated sterol to retain and make available the beneficial dermatological properties of the sterol or anti-rachitic 35 factor.
- the value of tlfis soap is usually somewhat enhanced if its lather is massaged into the skin for three to five minutes, as is often recommended for ordinary toilet soaps.
- the activation of the sterol for incorporation into the soap-of my invention may be performed in any suitable manner. I prefer, however, to irradiate ergosterol separately by the use of ultraviolet rays either producedartificially, as by the quartz mercury vapor lamp, or as obtained from the sun. The ergosterol is subjected to ultraviolet irradiation until the desired anti- 5 rachitic potency is produced.
- ergosterol In place of ergosterol, other sterols, such as cholesterol, phytosterol, zymosterol or cerevisterol, may be similarly irradiated; or substances, such as vegetable, animal or other oils susceptible of activation, may be employed. 5
- 'Byultraviolet light is meant light of wave length between about 1500 and 3900 Angstrom units.
- the irradiation with ultraviolet light in any case is carried out until an effective antirachitic potency is assured.
- the irradiation With ultraviolet light may be carried out until the typical absorption band of cholesterol or phytosterol caused by the activation of these sterols with ultraviolet rays is obtained.
- Activated cholesterol for instance, has a maximum absorption band at about 2480' Angstrom units, whereas cholesterol that has not been irradiated has two very distinctive absorption bands with maxima at 2700 and 2820 Angstrom units.
- rays of shorter wave length such as the X-ray
- waves of longer wave length such as the infra red rays
- cathode rays derived from various sources may be employed for the irradiation of the particular sterol which is to be incorporated in the soap.
- the preferred method for the incorporation of the irradiated ergosterol or other sterols in soap is to add the irradiated sterol to the warm soap mass in the crutcher for a thorough mixing before being poured into the frames; or if milled soap is being made, the irradiated sterol is best added to the soap from the drier in the same way and at the same time that the perfume mixture is added. After these materials are thoroughly mixed in this mixer, the mixture is fed into the milling machine and then on into the plodder from which a strip of finished soap is extruded and then cut into cake size, stamped, and wrapped. It will be understood that the irradiated sterol may be incorporated into any type of toilet soap, as for instance, ordinary white toilet soaps. v
- the quantity of irradiated ergosterol or other irradiated sterol to be added to the soap or produced in it by direct irradiation of the sterol containing soap will be governed by the anti-rachitic potency desired in the finished product.
- a soap containing 10 vitamin D ergosterol units per gram has been found to prevent rickets under laboratory conditions, but lower concentrations are often better for general purposes.
- the unit of anti-rachitic potency referred to is that defined on page 410 of the New and Nonofiicial Remedies by the Council on Pharmacy and Chemistry (1930 Ed.) of the American'Medical Association.
- soaps of my invention do have anti-rachitic properties and are actually capable, when applied in the form of aqueous solutions to a shaved white rat, of curing acute cases of rickets in rats, it is not intended, however, that the soaps of my invention shall necessarily have any anti-rachitic properties as normally used in the ordinary course of human toilet.
- the advantages derived from the use of soaps of my invention are rather instead those that arise from the beneficial dermatological properties that are possessed by or accompany the anti-rachitic factor, or principle.
- a new composition of matter for use with water for hygienic purposes comprising a soap having incorporated therein an anti-rachitic factor having beneficial dermatological properties, the soap being compatible with the antirachitic factor to retain and make available such properties upon use.
- a new composition of matter for use with water for hygienic purposes comprising a soap having incorporated therein a sterol activated by means of ultra violet light and having beneficial dermatological properties, the soap being compatible with said activated sterol to retain and make available such properties upon use.
- a new composition of matter for use with water for hygienic purposes comprising a soap having incorporated therein an irradiated sterol having beneficial dermatological properties, the soap being compatible with said irradiated sterol to retain and make available such properties upon use.
- a new composition of matter for use with water for hygienic purposes comprising a soap having incorporated therein an activated ergosterol having beneficial dermatological properties, the soap being compatible with said activated ergosterol to retain and make available such properties upon use.
- a new composition of matter for use with water for hygienic purposes comprising a soap having incorporated therein an irradiated ergosterol having beneficial dermatological properties, the soap being compatible with said irradiated ergosterol to retain and make available such properties upon use.
- a new composition of matter for use with water for hygienic purposes comprising a soap having incorporated therein a sufficient quantity of an anti-rachitic factor having beneficial dermatological properties to impart to the soap a potency equivalent to about 10 vitamin D ergosterol units per gram of soap. the soap being compatible with the anti-rachitic factor to retain and make available such properties upon use.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR742181D FR742181A (enrdf_load_stackoverflow) | 1931-06-18 | ||
US545367A US2060228A (en) | 1931-06-18 | 1931-06-18 | Soap |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US545367A US2060228A (en) | 1931-06-18 | 1931-06-18 | Soap |
Publications (1)
Publication Number | Publication Date |
---|---|
US2060228A true US2060228A (en) | 1936-11-10 |
Family
ID=24175936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US545367A Expired - Lifetime US2060228A (en) | 1931-06-18 | 1931-06-18 | Soap |
Country Status (2)
Country | Link |
---|---|
US (1) | US2060228A (enrdf_load_stackoverflow) |
FR (1) | FR742181A (enrdf_load_stackoverflow) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4230701A (en) * | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
US4335120A (en) * | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
US5532229A (en) * | 1994-04-28 | 1996-07-02 | Vieth; Reinhold W. | Topical administration of vitamin D to mammals |
US20040208891A1 (en) * | 2002-08-13 | 2004-10-21 | Ching-Yuang Lin | Active compound from fraction of cordyceps sinensis and use thereof |
US20070001005A1 (en) * | 2001-05-14 | 2007-01-04 | Innovision Research & Technology Plc | Electrical devices |
-
0
- FR FR742181D patent/FR742181A/fr not_active Expired
-
1931
- 1931-06-18 US US545367A patent/US2060228A/en not_active Expired - Lifetime
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4230701A (en) * | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
US4335120A (en) * | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
US5532229A (en) * | 1994-04-28 | 1996-07-02 | Vieth; Reinhold W. | Topical administration of vitamin D to mammals |
US20070001005A1 (en) * | 2001-05-14 | 2007-01-04 | Innovision Research & Technology Plc | Electrical devices |
US20040208891A1 (en) * | 2002-08-13 | 2004-10-21 | Ching-Yuang Lin | Active compound from fraction of cordyceps sinensis and use thereof |
Also Published As
Publication number | Publication date |
---|---|
FR742181A (enrdf_load_stackoverflow) | 1933-02-28 |
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