US20230081362A1 - Accommodating intraocular lens device - Google Patents
Accommodating intraocular lens device Download PDFInfo
- Publication number
- US20230081362A1 US20230081362A1 US17/937,864 US202217937864A US2023081362A1 US 20230081362 A1 US20230081362 A1 US 20230081362A1 US 202217937864 A US202217937864 A US 202217937864A US 2023081362 A1 US2023081362 A1 US 2023081362A1
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- US
- United States
- Prior art keywords
- lens
- power lens
- haptic
- intraocular lens
- lens device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Definitions
- the invention relates generally to an accommodating intraocular lens device and, more particularly, to an accommodating intraocular lens device configured for implantation in a lens capsule or sulcus of a subject's eye.
- Cataract surgery remains one of the most common surgical procedures, with over 16 million cataract procedures being performed worldwide. It is expected that this number will continue to increase as average life expectancies continue to rise. Cataracts are typically treated by removing the crystalline lens from the eye and implanting an intraocular lens (“IOL”) in its place. As conventional IOL devices are primarily focused for distance visions, they fail to correct for presbyopia and reading glasses are still required. Thus, while patients who undergo a standard IOL implantation no longer experience clouding from cataracts, they are unable to accommodate, or change focus from near to far, from far to near, and to distances in between.
- IOL intraocular lens
- an accommodating intraocular lens device having one of a high profile or a low profile.
- the accommodating intraocular lens device may comprise a base assembly and a power lens.
- the base assembly may comprise a first open end, a second end coupled to a base lens, and a haptic surrounding a central cavity.
- the haptic may comprise an outer periphery, an inner surface and a height between a first edge and a second edge.
- the power lens may comprise a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid.
- the power lens may be configured to fit within the central cavity.
- the first side of the power lens may be positioned at a predetermined distance from the first edge of the haptic.
- the accommodating intraocular lens may have a high profile, with the predetermined distance being in the range of about 0 mm to about 0 . 75 mm In another optional aspect, the predetermined distance may be about 0 . 01 % to about 37 % of the height of the outer periphery.
- the accommodating intraocular lens may have a low profile, with the predetermined distance being in the range of about 0 . 75 mm to about 1 . 5 mm In a further optional aspect, the predetermined distance may be about 38 % to about 75 % of the height of the outer periphery.
- the inner surface of the haptic may face the central cavity and the inner surface may comprise a plurality of spaced apart contact points configured to engage a portion of the peripheral edge of the power lens.
- outer grooves may be provided to extend along at least a portion of the height of the haptic.
- the outer grooves may be configured to permit the haptic to be radially compressed, radially expanded, or both.
- the outer grooves may be disposed in the outer periphery opposite the inner surface contact points.
- the haptic may further comprise a plurality of tabs extending radially inwardly into the cavity.
- the power lens may be secured to the base assembly by the plurality of tabs.
- the plurality of tabs comprise a bottom surface that is configured to contact the first side of the power lens.
- the bottom surface of the plurality of tabs may be positioned at a distance of about 0 mm to about 0.75 mm from the first edge of the haptic.
- the bottom surface of the tabs may also be provided at a distance, from the first edge of the haptic, of about 0.01% to about 37% of the height of the haptic.
- the bottom surface of the plurality of tabs may be positioned at a distance of about 0.75 mm to about I mm from the first edge of the haptic.
- the bottom surface of the tabs may also be provided at a distance, from the first edge of the haptic, of about 38% to about 75% of the height of the haptic.
- the haptic may further comprise a plurality of tables extending radially inwardly into the cavity.
- a channel may be formed between the plurality of tabs and the plurality of tables to secure the power lens to the base assembly.
- the accommodating intraocular lens device may further comprise a plurality of arms coupling the base lens to the haptic.
- the plurality of arms may vault the base lens away from the central cavity.
- the first side of the power lens may comprise one of a flexible membrane and an optic and the second side of the power lens may comprise the other of the flexible membrane and the optic.
- the power lens may further comprise an optic coupler disposed from the peripheral edge to couple the optic to the peripheral edge.
- the optic coupler may be angled to vault the optic toward the flexible membrane.
- the fluid contained in the closed cavity of the power lens may be one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether.
- the fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.
- an accommodating intraocular lens device may comprise a base and a power lens.
- the base may comprise an outer portion, an inner portion and a closed space defined between the outer and inner portions.
- the closed space may comprise a reservoir configured to contain a fluid.
- the inner portion may circumscribe a substantially circular space.
- the power lens may comprise a flexible membrane on one side, an optic on the opposing side and a circumferential peripheral edge coupling the flexible membrane and the optic. A portion of the circumferential peripheral edge may be configured to be in facing relation to at least a portion of the inner portion of the base.
- the base may be shaped as a ring.
- the base may comprise a base lens.
- the base may be shaped as an incomplete ring having two closed ends.
- the reservoir may extend around a portion of the circumference of the base at an arc degree of about 90 to about 350.
- a thickness of the inner portion is less than a thickness of the outer portion.
- the reservoir contains a fluid.
- the fluid may be any one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether.
- the fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.
- the power lens may further comprise a membrane coupler extending radially inwardly from the circumferential edge to couple the membrane with the peripheral edge.
- the power lens may further comprise an optic coupler disposed from the circumferential peripheral edge to couple the optic to the peripheral edge.
- the optic coupler is angled to vault the optic toward the flexible membrane.
- the base may further comprise upper and lower flanges extending radially inwardly and forming a channel adapted to accommodate the peripheral edge of the power lens.
- the reservoir may comprise an outer reservoir, an inner reservoir and a narrowed channel between the outer and the inner reservoir.
- the inner reservoir may comprise a support structure or a braided structure.
- the circumferential peripheral edge facing the inner portion of the base may be in direct physical contact with the inner portion.
- the flexible membrane, the optic and the circumferential peripheral edge define a closed cavity within the power lens.
- the closed cavity may be configured to contain a fluid.
- the fluid may be any one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether.
- the fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.
- a toric base assembly for an accommodating intraocular lens device.
- the toric base assembly can be used as a part of a two-part accommodating intraocular lens device that further includes a power lens that can be provided in connection with the toric base assembly.
- the toric base assembly provides for an asymmetric translation of a radially compressive force onto a power lens that is provided centrally within the toric base assembly.
- the toric base assembly may thus comprise a base assembly comprising a base lens and a substantially circular haptic surrounding the base lens.
- the substantially circular haptic may have an outer periphery and at least one region in which the flexibility of the haptic is greater than the flexibility in remaining regions of the haptic.
- Application of a radially compressive force may result in an asymmetric deformation of the substantially circular haptic and the asymmetric deformation of the substantially circular haptic may provide a toric power change in one or both of the base lens and the power lens.
- the at least one region may comprise two regions on opposing sides of the substantially circular haptic.
- the greater structural flexibility may be provided by reducing a thickness of the at least one region.
- the greater structural flexibility may be provided by forming one or more shaped cut-outs in the circular haptic in the at least one region.
- the circular haptic may comprise at least one portion that extends radially outwardly of the outer periphery.
- the circular haptic may comprise two portions that extend radially outwardly of the outer periphery.
- the two regions may be on opposing sides of the circular haptic.
- the substantially circular haptic may comprise at least one portion that extends radially outwardly of the outer periphery.
- the accommodating intraocular lens device may further comprise one or more tabs extending radially inwardly from the outer periphery.
- the accommodating intraocular lens device may further comprise a power lens configured to engage the circular haptic.
- the asymmetric deformation of the substantially circular haptic provides a toric power change in both of the base lens and the power lens.
- an accommodating intraocular lens device may be provided with a retaining system that permits the power lens and the base assembly to couple or interlock.
- the accommodating intraocular lens device may comprise a base assembly comprising a first open end, a second end comprising a base lens, and a haptic surrounding the base lens.
- the haptic may comprise an outer periphery surrounding a cavity.
- a power lens may be sized to fit within the cavity and a retaining system may be provided to secure the power lens within the cavity.
- the retaining system may comprise a plurality of tabs extending radially inwardly from the haptic and into the cavity.
- the retaining system may comprise a plurality of fins extending from a peripheral edge of the power lens and a plurality of corresponding recesses defined within an inner periphery of the haptic.
- the plurality of recesses may each be defined by a raised portion and an entry passage on at least one side of the raised portion.
- the retaining system may comprise a pair of flanges extending outwardly from a peripheral edge of the power lens and a channel.
- the channel may be formed in the inner periphery of the haptic.
- the channel may also be formed between a pair of opposing tabs extending from the inner periphery of the haptic.
- the retaining system may comprise a plurality of tabs that extend radially inwardly from the first open end of the base assembly.
- the haptic is substantially circular.
- an accommodating intraocular lens device in which the power lens is attachable or attached to a base assembly.
- the accommodating intraocular lens device may comprise a base assembly and a power lens.
- the base assembly may comprise a first open end, an open second end, and a substantially circular haptic surrounding the base lens.
- the substantially circular haptic may comprise an outer periphery and an inner periphery facing a cavity.
- the power lens may be sized to fit within the cavity.
- the power lens may comprise a circumferential peripheral edge, wherein at least a portion of the circumferential peripheral edge may be engaged with the inner periphery of the substantially circular haptic.
- the base assembly does not comprise an optic or lens in addition to the power lens.
- a portion of the power lens may be attached to the substantially circular haptic.
- the portion of the power lens that is attached to the substantially circular haptic may be one or both of the circumferential peripheral edge or the posterior edge of the power lens.
- the power lens may be attached to the substantially circular haptic by one or a combination selected from the group consisting of: bonding and insert-molding.
- FIG. 1 A depicts a perspective view of a fluid-filled base assembly, in accordance with an embodiment of the present disclosure.
- FIG. 1 B depicts a cross-sectional view of the fluid-filled base assembly of FIG. 1 A .
- FIG. 1 C depicts an exploded perspective view of a power lens being inserted into the fluid-filled base assembly of FIG. 1 A
- FIG. 2 A depicts a perspective view of a fluid-filled open base ring, in accordance with an embodiment of the present disclosure.
- FIG. 2 B depicts a top plan view of the fluid-filled open base ring of FIG. 2 A .
- FIG. 2 C depicts a cross-sectional view of the fluid-filled open base ring of FIG. 2 A .
- FIG. 3 A depicts a perspective view of a fluid-filled closed base ring, in accordance with an embodiment of the present disclosure.
- FIG. 3 B depicts a top plan view of the fluid-filled closed base ring of FIG. 3 A .
- FIG. 3 C depicts an exploded perspective view of a power lens coupled to the fluid-filled closed base ring of FIG. 3 A .
- FIG. 4 A depicts a perspective view of a power lens coupled to a fluid-filled closed base ring, in accordance with an embodiment of the present disclosure.
- FIG. 4 B depicts a perspective view of a power lens coupled to a fluid-filled open base ring, in accordance with an embodiment of the present disclosure.
- FIG. 5 A depicts a perspective view of a power lens having a fluid transfer system, in accordance with an embodiment of the present disclosure.
- FIG. 5 B is a close up view of a fluid transfer system, in accordance with an embodiment of the present disclosure.
- FIG. 6 A depicts a perspective view of a toric base assembly, in accordance with an embodiment of the present disclosure.
- FIG. 6 B depicts a top plan view of the toric base assembly of FIG. 6 A .
- FIG. 7 A depicts a perspective view of a toric base assembly, in accordance with an embodiment of the present disclosure.
- FIG. 7 B depicts a top plan view of the toric base assembly of FIG. 7 A .
- FIG. 8 A depicts a perspective view of a base assembly, in accordance with an embodiment of the present disclosure.
- FIG. 8 B depicts a top plan view of the base assembly of FIG. 8 A .
- FIG. 8 C depicts a cross-sectional view of the base assembly of FIG. 8 A .
- FIG. 9 A depicts a perspective view of an accommodating IOL configured to position a power lens closer to a base lens of the base assembly, in accordance with an embodiment of the present disclosure.
- FIG. 9 B depicts a top plan view of the accommodating IOL of FIG. 9 A .
- FIG. 9 C depicts a cross-sectional view of the accommodating IOL of FIG. 9 A .
- FIG. 10 A depicts an exploded perspective view of a low profile accommodating IOL, in accordance with an embodiment of the present disclosure.
- FIG. 10 B depicts a perspective view of the low profile accommodating IOL of FIG. 10 A .
- FIG. 10 C depicts a top plan view of the low profile accommodating IOL of FIG. 10 A .
- FIG. 10 D depicts a perspective cross-sectional view of the low profile accommodating IOL of FIG. 10 A .
- FIG. 11 A depicts a perspective view of an accommodating IOL comprising a base assembly and a power lens having a fin-lock, in accordance with an embodiment of the present disclosure.
- FIG. 11 B depicts an exploded perspective view of the accommodating IOL of FIG. 11 A
- FIG. 11 C depicts a top plan view of the accommodating IOL of FIG. 11 A
- FIG. 11 D depicts a cross-sectional view of the accommodating IOL of FIG. 11 A
- FIG. 12 A depicts an exploded perspective view of an accommodating IOL having a base assembly and a power lens with a plate haptic, in accordance with an embodiment of the present disclosure.
- FIG. 12 B depicts an exploded plan view of the accommodating IOL of FIG. 12 A .
- FIG. 12 C depicts a top plan view of the power lens of the accommodating IOL of FIG. 12 A .
- FIG. 12 D depicts a top plan view of the accommodating IOL of FIG. 12 A .
- FIG. 12 E depicts a cross-section view of the accommodating IOL of FIG. 12 A .
- FIG. 12 F depicts a bottom perspective view of the accommodating IOL of FIG. 12 A .
- FIG. 13 A depicts a perspective view of a base assembly having extended tabs, m accordance with an embodiment of the present disclosure.
- FIG. 13 B depicts a top plan view of the base assembly of FIG. 13 A .
- FIG. 13 C depicts a cross-sectional view of the base assembly of FIG. 13 A .
- FIG. 14 A depicts a perspective view of a base ring, in accordance with an embodiment of the present disclosure.
- FIG. 14 B depicts a top plan view of the base ring of FIG. 14 A .
- FIG. 14 C depicts a cross-sectional view of the base ring of FIG. 14 A .
- FIG. 14 D depicts an alternative cross-sectional view of the base ring of FIG. 14 A .
- FIG. 14 E depicts a perspective view of a mesh braid that may be incorporated into the base ring of FIG. 14 D .
- FIG. 15 A depicts a perspective view of an accommodating IOL having a one-piece base assembly and a power lens, in accordance with an embodiment of the present disclosure.
- FIG. 15 B depicts a top plan view of the accommodating IOL of FIG. 15 A
- FIG. 15 C depicts a cross-sectional view of the accommodating IOL of FIG. 15 A
- FIG. 15 D depicts a bottom perspective view of the accommodating IOL of FIG. 15 A
- FIG. 16 A depicts a perspective view of an accommodating IOL having a no gap base assembly, in accordance with an embodiment of the present disclosure.
- FIG. 16 B depicts a side plan view of the accommodating IOL of FIG. 16 A
- FIG. 16 C depicts a perspective view of a no gap base assembly that may be utilized in the accommodating IOL of FIG. 16 A
- FIG. 16 D depicts a perspective view of a power lens that may be utilized m the accommodating IOL of FIG. 16 A
- FIG. 16 E depicts a top plan view of the accommodating IOL of FIG. 16 A
- FIG. 16 F depicts a cross-sectional view of the accommodating IOL of FIG. 16 A
- Like numerals refer to like parts throughout the several views of the drawings.
- the power changing feature of the IOL is driven by fluid optics within a closed volume of a power lens that comprises a flexible membrane and a lens or optic.
- a closed volume of a power lens that comprises a flexible membrane and a lens or optic.
- One significant advantage of this embodiment is that the closed volume of the power lens that spaces apart the flexible membrane and the lens maintains a substantially constant volume and therefore avoids many of the problems associated with fluid optic IOLs that require substantial changes in volume, i.e., fluid being fed into the chamber from reservoirs.
- the many disadvantages exhibited by fluid optics having changing volumes include non-uniform power change and buckling.
- Certain embodiments of the IOLs and the power lens disclosed herein may avoid or mitigate such problems by maintaining a substantially constant volume, while at the same time maintaining good optical quality throughout the range of power change. Additionally, various embodiments of the IOLs that comprise a two-part assembly of the power lens and the base assembly as described herein provide a smaller delivery profile, a smaller implant profile or both, so as to require a substantially smaller incision size for implantation. This, in turn, may have the concomitant advantage of reducing biocompatibility issues associated with the delivery and implantation of larger IOLs and may result in faster healing and a more stable refraction.
- the IOLs disclosed herein may be configured in any number of ways.
- the IOLs may comprise a base assembly and a power lens that can be coupled within the base assembly.
- the radially compressive forces exerted on an implanted IOL may be concentrated onto a flexible membrane of the power lens to cause the flexible membrane to change in curvature.
- the lens or optic of the power lens may be configured to axially displace toward the flexible membrane in response to its change in curvature. This axial displacement may be facilitated by coupling the optic to the peripheral edge of the IOL in a manner that permits the optic to float.
- fluid adhesion or surface tension may pull the optic or lens of the power lens toward the flexible membrane.
- the radially compressive forces exerted on the power lens may be concentrated onto the optic to cause the optic to axially displace and to push the flexible membrane in the same direction as the axial displacement of the optic to effectuate the change in curvature of the flexible membrane.
- the radially compressive forces on the power lens may be exerted on both the optic and the flexible membrane to cause the axial displacement and change in curvature, respectively.
- the radially compressive forces exerted on the power lens may be applied to one or both of the flexible membrane and the optic to cause the change in curvature of the flexible membrane and to cause axial displacement of the optic toward the flexible membrane, while maintaining a constant volume during radial compression.
- the term “constant volume” includes a volume which changes no more than about 1% from its resting state, no more than about 2% from its resting state, no more than about 3% from its resting state, no more than about 4% from its resting state, no more than about 5% from its resting state, no more than about 10% from its resting state, no more than about 15% from its resting state, no more than about 20% from its resting state, no more than about 25% from its resting state, no more than about 30% from its resting state, no more than about 35% from its resting state, no more than about 40% from its resting state, no more than about 45% from its resting state, no more than about 50% from its resting state, no more than about 55% from its resting state, no more than about 60% from its resting state, no more than about 65% from its resting state, no more than about 70% from its resting state, and no more than about 75% from its resting state.
- the term “constant volume” refers to a volume that changes in a range that includes and is between any two of the foregoing values.
- the term “resting state” describes the configuration of the IOL or power lens when no radially compressive forces are exerted on the IOL or the power lens.
- the term “power lens” may refer to an assembly that provides a range of accommodation or refractive correction in response to the application of radially compressive or expansive forces.
- the power lens may provide a range of accommodation of about 1 diopter, about 2 diopters, about 3 diopters, about 4 diopters, about 5 diopters, about 6 diopters, about 7 diopters, about 8 diopters, about 9 diopters, about 10 diopters, about 11 diopters, about 12 diopters, about 13 diopters, about 14 diopters, about 15 diopters, about 16 diopters, about 17 diopters, about 18 diopters, about 19 diopters, or about 20 diopters.
- the power lens may provide a range of accommodation between and including any two of the foregoing values.
- the term “power lens” may also include an assembly which comprises a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid.
- the first and second sides may be a flexible membrane or an optic.
- the first side may be one of a flexible membrane or an optic and the second side may be the other of a flexible membrane or an optic.
- the power lens may further be characterized as having a closed fluid-filled cavity having a constant volume throughout the range of accommodation.
- Certain embodiments of the two-part accommodating IOL devices disclosed herein may provide a number of advantages owing to their separate two-part construction. Implantation of the two-part IOL device may require a significantly reduced incision size, as the two parts of the IOL device (e.g., the base assembly and the power lens) are implanted separately and thus significantly reducing the delivery profile for implantation.
- the reduced incision size may provide a number of advantages, including obviating the need for anesthesia and sutures to close the incision site and improved surgical outcomes.
- the incision size required to implant the two-part accommodating IOL devices is less than about 5 mm, less than about 4 mm, less than about 3 mm, or less than about 2 mm
- each part of the two-part accommodating IOL device may be provided in a delivery state having a delivery profile that is less than about 5 mm, less than about 4 mm, less than about 3 mm, or less than about 2 mm
- the delivery state of each part of the two-part accommodating IOL device may be provided when each part is rolled, folded or otherwise compressed to reduce its size for delivery.
- a hinge or a predetermined crease may be provided on one or both of the base assembly and the power lens to facilitate folding or rolling into the delivery state.
- Implanting the base assembly into the lens capsule will provide the physician an impression as to the size of the patient's lens capsule and will thus help select the correct size of the power changing lens that will subsequently be implanted into the base assembly.
- FIG. 1 A depicts a perspective of an embodiment of a fluid-filled base assembly 100 of an accommodating IOL.
- FIG. 1 B provides a cross-sectional view of the fluid-filled base assembly 100 .
- the base assembly 100 shown in FIGS. 1 A- 1 B may include a base lens 110 and a haptic system 120 disposed substantially circumferentially around the base lens 110 .
- the haptic system 120 may be sized and configured to receive a separate power lens, such as the power lens 195 , 350 depicted in FIGS. 1 C and 3 C respectively.
- the power lens 195 , 350 can be inserted within the base assembly 100 to form a two-part accommodating IOL device.
- the haptic system 120 may include a reservoir 130 that extends through at least a portion of the haptic system 120 .
- the reservoir 130 can extend around a portion of the circumference of the haptic system 120 , as depicted in FIGS.
- the reservoir 130 has an arc degree of at least 90, at least 100, at least 110, at least 120, at least 130, at least 140, at least 150, at least 160, at least 170, at least 180, at least 190, at least 200, at least 210, at least 220, at least 230, at least 240, at least 250, at least 260, at least 270, at least 280, at least 290, at least 300, at least 310, at least 320, at least 330, at least 340, at least 350, or about 360.
- the reservoir 130 can extend around a portion of the circumference of the haptic system 120 within a range that includes and is between any two of the foregoing values, e.g. 180 arc degrees to 270 arc degrees. In accordance with another aspect, the reservoir 130 can extend around an entire circumference of the haptic system 120 , e.g., 360 arc degrees, as provided in the embodiment depicted in FIGS. 1 A- 1 C .
- the reservoir 130 can be defined or bounded by an inner region 180 and outer region 150 .
- the reservoir 130 is configured to contain a fluid (e.g., a liquid or a gas).
- the fluid can be selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether.
- the fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.
- the fluid contained within the reservoir 130 can function to distribute forces applied to the outer region 150 of the haptic system 120 to the inner region 180 .
- fluid contained within the reservoir 130 can be used to substantially evenly transmit compressive forces applied to the outer region 150 of the haptic system 120 , e.g. forces caused from the relaxation of the ciliary muscles, to the inner region 180 .
- Forces transmitted to the inner region 180 can subsequently be transmitted to a power lens ( 195 , 350 as depicted in FIGS. 1 C and 3 C respectively) that is coupled centrally within the base assembly 100 .
- forces transmitted to the inner region 180 can be transmitted to the base lens 110 .
- the fluid-filled base assembly 100 can include an upper flange 160 and a lower flange 170 extending inwardly from the haptic system 120 along at least a portion of the circumference of the haptic system 120 .
- the upper flange 160 and the lower flange 170 define a channel that is configured to secure a power lens 195 to the fluid-filled base assembly 100 .
- FIG. 1 C depicts an exploded perspective view of a power lens 195 being inserted into the base assembly 100 , with the peripheral edge 197 of the power lens 195 being adapted to fit within the channel defined by the upper and lower flanges 160 , 170 .
- the peripheral edge 197 if not the entirety of the peripheral edge 197 is configured to engage or directly contact the inner region 180 so as to effectively transmit the forces transmitted to the inner region 180 onto one or both of the first and second sides 196 , 199 of the power lens 195 to provide accommodation.
- the first and second sides may be a flexible membrane or an optic or, alternatively, the first side may be one of a flexible membrane or an optic and the second side may be the other of a flexible membrane or an optic.
- FIG. 2 A depicts a perspective view of an open fluid-filled base ring 200 of an accommodating IOL.
- FIGS. 2 B and 2 C depict top plan and cross-sectional views of the open fluid-filled base ring 200 , respectively.
- the open fluid-filled base ring 200 represents an alternative embodiment of the fluid-filled base assembly 100 discussed above with reference to FIGS. 1 A- 1 C and can be used in connection with the power lens 195 depicted in relation to FIG. 1 C .
- the open fluid-filled base ring 200 includes a haptic system 210 .
- the open fluid-filled base ring 200 differs from the base assembly 100 of FIG. 1 in that the open fluid-filled base ring 200 does not include a base lens. As such, any visual correction must be provided by a power lens 195 that may be inserted into the open fluid-filled base ring 200 in a manner depicted in relation to FIG. 1 C .
- the open fluid-filled base ring 200 is an open ring, i.e., it is not a complete ring.
- the open fluid-filled base ring 200 is provided as a C-shape having two closed ends, 210 A, 210 B, in which its outer periphery is less than 360 arc degrees.
- the open fluid filled base ring 200 is provided as a circular shape of substantially about 360 arc degrees but comprises a pair of closed ends such that the inner cavity 250 is not a continuous circumferential volume but comprises a circumferential volume having a pair of closed ends. Both embodiments permit for the open fluid-filled base ring 200 to increase the diameter defined within the central area of the haptic 210 and accommodate power lenses of varying diameters.
- the C-shaped or incomplete ring configuration can also allow for toric or non-uniform deformation of a power lens, as a portion of the periphery of the power lens will not be contacted by the open fluid-filled base ring 200 and, therefore, the uncontacted portion of the periphery of the power lens will not experience radially-inward forces applied by the open fluid-filled base ring 200 .
- the open fluid-filled base ring 200 can transmit a radially-compressive forces around only a pre-determined portion of the circumference of a power lens 195 peripheral edge 197 that is provided or coupled within the open fluid-filled base ring 200 so as to provide an asymmetric radial compression of the power lens 195 implanted within the open fluid-filled base ring 200 .
- the open fluid-filled base ring 200 has an arc degree of at least 180, at least 190, at least 200, at least 210, at least 220, at least 230, at least 240, at least 250, at least 260, at least 270, at least 280, at least 290, at least 300 at least 310, at least 320, at least 330, at least 340, at least 350, or 360.
- the open-fluid filled base ring has a circumference that defines an angle that is provided within a range between any two of the foregoing values.
- the open fluid-filled base ring 200 includes upper and lower flanges 220 and 230 , forming a channel 240 therebetween.
- the channel 240 may be configured to receive and secure the power lens.
- the haptic system 210 includes a reservoir 250 (see FIG. 2 C ) that extends through at least a portion of the haptic system 210 , e.g. around substantially the entire haptic system 210 .
- the haptic system 210 may include an inner wall 260 and an outer wall 270 that define the reservoir 250 .
- the inner wall 260 may have a thickness that is less than a thickness of the outer wall 270 .
- the thickness of the inner wall 260 may be about 90%, about 80%, about 70%, about 60%, about 50%, about 40%, about 30%, about 20%, about 10% and about 5% of the thickness of the outer wall 270 .
- the thickness of the inner wall 260 may also be within a range that is between and includes any two of the foregoing values.
- the reservoir 250 may be configured to contain a fluid.
- the fluid may be selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether.
- the fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.
- the fluid contained within the reservoir 250 may function to distribute forces applied to the outer wall 270 of the haptic system 210 to the inner wall 240 .
- the fluid contained within the reservoir 250 may be used to substantially evenly transmit compressive forces applied to a periphery of the haptic system 210 , e.g. forces caused from the contraction and/or relaxation of the ciliary muscles. Forces transmitted to the inner wall 260 may subsequently be transmitted to a power lens contained within the channel 240 .
- FIG. 3 A depicts a perspective view of a fluid-filled base ring 300 , in accordance with another embodiment of the present disclosure.
- FIG. 3 B is a top plan view of the fluid-filled base ring 300 .
- the fluid-filled base ring 300 is substantially similar to the open fluid-filled base ring 200 of FIGS. 2 A-C , with the primary difference being that the fluid-filled base ring 300 is a closed ring, rather than an open ring.
- the fluid-filled base ring 300 may also include a haptic system 310 that is ring shaped.
- the fluid-filled base ring 300 may also include an upper flange 320 and a lower flange 330 extending radially inwardly from the haptic system 310 .
- the upper flange 320 and the lower flange 330 together define a channel that is configured to secure a power lens within a central portion of the fluid-filled base ring 300 .
- An inner wall 340 is defined between the upper flange 320 and the lower flange 330 .
- FIG. 3 C depicts an exploded perspective view of a power lens 350 that is configured to be coupled to the fluid-filled base ring 300 .
- the fluid-filled base ring 300 is configured to secure the power lens 350 to form an accommodating IOL.
- the power lens 350 includes a flexible membrane 352 on one side, an optic 354 on the opposing side, and a circumferential peripheral edge 358 coupling the flexible membrane and the optic 354 .
- a membrane coupler 356 can extend radially inwardly from the internal side of the circumferential peripheral edge 358 to couple the membrane 352 to the peripheral edge 358 .
- at least a portion of the peripheral edge 358 is in direct contact with the inner wall 340 of the fluid-filled base ring 300 .
- the entirety of the peripheral edge 358 is in direct contact with the inner wall 340 of the fluid-filled base ring 300 .
- the power lens 350 can comprise an optic coupler 360 extending radially inwardly from the internal side of the circumferential peripheral edge 358 to couple the optic 354 to the peripheral edge 358 .
- the optic coupler 360 is angled toward the flexible membrane 352 such that it vaults the optic 354 toward the flexible membrane 352 . See, e.g., power lens 920 of FIG. 9 C and power lens 1020 of FIG. 10 D for exemplary cross-sectional views.
- the power lens 350 can be identical to the power lens 920 of FIG. 9 C or the power lens 1020 of FIG. 10 D .
- any of the features disclosed with respect to the accommodating intraocular lenses in the above-cited references may be applied to any of the base assemblies, the power lenses, or the accommodating IOLs disclosed herein.
- the various one-piece accommodating IOL embodiments disclosed in U.S. Patent application Publication Nos. 2013/0053954, 2014/0180403, and 2015/0105760 can be utilized as the power lens 350 .
- U.S. patent application Ser. No. 14/447,621 discloses a two-piece accommodating IOL that utilizes a base assembly and a power lens inserted into the base assembly (sometimes referred to as an accommodating IOL or IOL). It should be understood that various embodiments are possible.
- FIG. 4 A depicts a perspective view of a power lens 350 coupled to a fluid-filled base ring 300 .
- FIG. 4 B depicts a perspective view of a power lens 350 coupled to an open fluid-filled base ring 200 .
- only at least a portion of the circumferential peripheral edge 358 is in direct physical contact with the inner wall 240 , 340 of the fluid-filled base ring 200 , 300 (e.g. FIG. 4 B ).
- the entire circumferential edge 358 is in direct contact with the inner wall 340 of the fluid-filled base ring 300 (e.g., FIG. 4 A ).
- FIG. 5 A provides a perspective view of a fluid-exchange power lens 500 in accordance with an embodiment of the present disclosure.
- the power lens 500 shown in FIG. 5 A can include the components as described with respect to the power lens 350 shown in, for example, FIG. 3 C .
- the power lens 500 includes a reservoir for storing a fluid that can be transferred to a fluid-filled base assembly that forms part of an accommodating IOL.
- the power lens 500 includes a fluid transfer valve 510 that is configured to be removably coupled to the fluid-filled base assembly (see FIG. 5 B ).
- the fluid transfer valve 510 functions to provide a fluid communication between the power lens 500 and a base assembly shown in FIGS. 1 - 4 .
- FIG. 5 B depicts an embodiment of a fluid transfer system for transferring fluid between a power lens and a fluid-filled base assembly of an accommodating IOL.
- the fluid transfer valve 510 is configured to interact with a receiving valve 520 that is disposed on an inner wall of the fluid-filled base assembly (e.g., 180 , 240 , 340 of FIGS. 1 B, 2 A, 3 A , respectively.
- the fluid transfer valve 510 can be implemented as part of a power lens 500 and the receiving valve 520 can be implemented as part of a fluid-filled base assembly 590 or vice versa.
- the fluid transfer valve 510 includes a canal 530 leading to a one-way valve 540 .
- the receiving valve 520 includes valve release canal 550 .
- the receiving valve 520 includes its own one-way valve 560 .
- both one-way valves 530 , 560 are closed, and no fluid escapes either the power lens 500 or the fluid-filled base assembly 590 .
- the canal 530 of the fluid transfer valve 510 is inserted into the one-way valve 560 of the fluid-filled base assembly 590 .
- the canal 530 forces open the one-way valve 560 .
- the valve release canal 550 forces open the one-way valve 540 .
- both one-way valves 540 , 560 are pushed open, and fluid can freely flow between the power lens 500 and the fluid-filled base assembly 590 .
- FIGS. 6 and 7 depict embodiments of a toric base assembly 600 , 700 .
- the base assembly 600 , 700 comprises a base lens 610 , 710 and a substantially circular haptic system 620 , 720 having an outer periphery and at least two regions having different flexibility. Because at least two regions have greater flexibility 640 , 730 than in the remaining regions of the haptic system 620 , 720 , the application of a radially-compressive force onto the outer periphery of the haptic system 620 , 720 results in an asymmetric deformation of the haptic system 620 , 720 in the regions of greater flexibility 640 , 730 .
- the regions of greater flexibility 640 , 730 are radially compressed or compressible to a greater extent than the remaining regions of the haptic system 620 , 720 .
- This asymmetric deformation may provide a toric power change in one or both of a base lens 610 , 710 and a power lens that is provided within the haptic system 620 , 720 .
- FIGS. 6 A- 6 B depicts one embodiment of the toric base assembly 600 .
- FIG. 6 A depicts a perspective view of a toric base assembly 600 of an accommodating toric IOL, in accordance with an embodiment of the present disclosure.
- FIG. 6 B provides a top plan view of the toric base assembly 600 .
- the toric base assembly 600 includes a base lens 610 and substantially circular haptic system 620 .
- the toric base assembly 600 includes a plurality of tabs 630 to engage an inserted power lens (not depicted).
- the outer periphery of the haptic system 620 is configured to receive deforming forces caused by the ciliary muscles of the eye to cause radially-inward compression of the haptic system 620 .
- portions of the haptic system 620 have greater structural flexibility, leading to uneven translation of a radially-inwardly applied force by various portions of the haptic system 620 .
- cutouts 640 are formed in the haptic system 620 to create greater flexibility proximate the cutouts 640 .
- the cutouts 640 can be formed to provide an area of the haptic 620 that is thinner than the remaining areas of the haptic 620 .
- FIGS. 7 A and 7 B provide perspective and top plan views, respectively, of an alternative toric base assembly 700 , in accordance with an embodiment of the present disclosure.
- the toric base assembly 700 includes a base lens 710 and a haptic system 720 .
- the haptic system 720 in addition to having cutouts 740 to create greater flexibility in certain regions of the haptic system 720 , the haptic system 720 includes two extended regions 730 that extend beyond the circumference defined by the haptic system 720 .
- the extended regions 730 and the cutouts 740 cause an unequal distribution of compressive forces, resulting in toric deformation of either or both the base lens 710 and an inserted power lens.
- the accommodating IOL may be provided with a base assembly that permits for varying profiles.
- the varying profiles may be provided by configuring the base assembly such that the power lens is placed farther away from the base lens (i.e., high profile) or closer to the base lens (i.e., low profile).
- FIGS. 8 A- 8 C depict an embodiment of a high profile IOL base assembly 800 .
- FIG. 8 A depicts a perspective view of the base assembly 800 and
- FIGS. 8 B and 8 C depict top plan and cross-sectional views, respectively, of the base assembly 800 .
- the base assembly 800 includes a first open end 800 A and a second end 800 B that may optionally include a base lens 830 .
- the haptic system 810 includes an outer periphery and an inner surface facing a central cavity.
- the inner surface may comprise a plurality of spaced-apart contact points 862 configured to engage a portion of a peripheral edge of an implanted power lens (not depicted) that may be provided to fit within a central cavity of the base assembly 800 .
- a plurality of tabs 840 may be provided to extend into a cavity 850 and to create a plurality of recesses 860 within the cavity 850 to retain a portion of a peripheral edge of a power lens.
- a plurality of tables 870 extend from a bottom of the base assembly 800 into the cavity 850 along portions of a periphery of the cavity 850 .
- the tables 870 rise to a level such that a top surface of the tables 870 is in substantially the same plane formed by the bottom surfaces of the recesses 860 .
- the tables 870 in combination with the recesses 860 ensure that an inserted power lens is secured at a desired position within the cavity 850 with respect to the base lens 830 .
- the haptic system 810 has a height h 2 between a first edge and a second edge of its outer periphery.
- the power lens comprises a first side, a second side and a peripheral edge coupling the first and second sides.
- the power lens may further comprise a closed cavity configured to house a fluid
- the first side of the power lens is positioned at a predetermined distance h 1 from the first edge of the haptic system 810 .
- This predetermined distance h 1 determines the profile of the base assembly 800 .
- the predetermined distance h 1 may be in the range of about 0 mm to about 0.75 mm.
- the predetermined distance h 1 may be in the range of about 0.01% to about 37% of the height of the haptic h 2 .
- the predetermined distance can be measured by reference to a bottom surface of a plurality of tabs 840 that is used to secure a first side of the power lens.
- the bottom surface of the tabs may be positioned at a distance of about 0 mm to about 0.75 mm from the first edge of the haptic system 810 or at a distance, from the first edge of the haptic system 810 , of about 0.01% to about 37% of the height h 2 of the haptic system 810 .
- the haptic system 810 may be substantially circular with a plurality of outer grooves 820 .
- the outer grooves 820 may extend along at least a portion of the height of the haptic system 810 .
- the outer grooves 820 may be configured to permit the haptic to be radially compressed, radially expanded, or both.
- the outer grooves 820 may be disposed in the outer periphery of the haptic system 810 opposite the inner surface contact points 862 .
- FIGS. 9 and 10 depict embodiments of a low profile base assembly.
- FIG. 9 A depicts a perspective view of an accommodating intraocular lens 900 including a base assembly 900 and a power lens 920 coupled to the base assembly 910 .
- the base assembly 900 of the accommodating IOL 900 is configured to position the power lens 920 deeper within the base assembly 910 , and closer to a base lens of the base assembly 910 .
- FIG. 9 B provides a top plan view of the accommodating IOL and
- FIG. 9 C provides a cross-sectional view of the accommodating IOL including the base assembly 900 and the power lens 920 .
- the accommodating IOL includes a power lens 920 that is secured in the base assembly 900 , and held in place, in part, by a plurality of tabs 930 that extend radially inwardly from the base assembly 900 into a central cavity within the base assembly 900 .
- the bottom surface of the tabs 930 contact a first side of the power lens 920 , similarly as with FIG. 8 C .
- the power lens 920 is positioned proximate a base lens 940 .
- the power lens 920 comprises a flexible membrane 950 , and a power lens optic 960 .
- the flexible membrane 950 and the power lens optic are spaced apart, and a fluid fills the space between the two.
- the power lens optic 960 and the base lens 940 are proximate one another.
- a haptic system 910 has a height h 2 between a first edge and a second edge of its outer periphery.
- the power lens comprises a first side, a second side and a peripheral edge coupling the first and second sides.
- the power lens may further comprise a closed cavity configured to house a fluid
- the first side of the power lens is positioned at a predetermined distance h 1 from the first edge of the haptic system 910 .
- This predetermined distance h 1 determines the profile of the base assembly 900 .
- the predetermined distance h 1 may be in the range of about 0 mm to about 0.75 mm.
- the predetermined distance h 1 may be in the range of about 0.01% to about 37% of the height of the haptic h 2 .
- the predetermined distance can be measured by reference to a bottom surface of a plurality of tabs 930 that is used to secure a first side of the power lens.
- the bottom surface of the tabs may be positioned at a distance of about 0.75 mm to about 1.5 mm from the first edge of the haptic system 810 or at a distance, from the first edge of the haptic system 910 , of about 38% to about 75% of the height h 2 of the haptic system 910 .
- the haptic system 910 may be substantially circular with a plurality of outer grooves 920 .
- the outer grooves 920 may extend along at least a portion of the height of the haptic system 910 .
- the outer grooves 920 may be configured to permit the haptic to be radially compressed, radially expanded, or both.
- the outer grooves 920 may be disposed in the outer periphery of the haptic system 910 opposite the inner surface contact points 962 .
- the lower profile of the accommodating IOL amplifies power change by the accommodating IOL 900 , as will be described in greater detail below with respect to FIG. 10 .
- FIGS. 10 A- 10 D depict another embodiment of a low profile accommodating IOL 1000 , in which a low profile base assembly 1010 is configured to place a power lens 1020 deeper within the base assembly 1010 , in close proximity with a base lens 1030 , to create a greater range of optical power possible with a particular IOL configuration.
- the low profile accommodating IOL 1000 includes a base assembly 1010 , and a power lens 1020 configured to be secured within the base assembly 1010 .
- the base assembly 1010 comprises a haptic portion 1015 for translating forces applied to the periphery of the haptic portion 1015 to the power lens 1020 .
- the power lens 1020 includes a flexible membrane 1050 and a power lens optic 1040
- the base assembly 1010 includes a haptic portion 1015 for translating forces applied to the periphery of the haptic portion 1015 to the power lens 1020 and a base lens 1030 .
- the base lens 1030 and the power lens optic 1040 are proximate one another, and the lower profile of the accommodating IOL amplifies power change by the power lens 1020 .
- Change in power by the accommodating IOL 1000 is largely produced by accommodation of the power lens 1020 .
- accommodation of the power lens 1020 is most effectively produced by applying forces to the membrane 1050 , rather than to the power lens optic 1040 .
- power change of the accommodating IOL 1000 is most efficient when forces applied to the periphery of the haptic 1015 are translated efficiently to the membrane 1050 .
- the low profile accommodating IOL 1000 efficiently translates forces from the haptic 1015 to the membrane 1050 in several ways.
- placement of the power lens 1020 deeper within the haptic 1015 leads to more efficient translation of forces from the haptic 1015 to the power lens 1020 (which comprises the membrane 1050 ). This is due, at least in part, to the fact that when the power lens 1020 is positioned higher up within the haptic 1015 , a greater proportion of the forces exerted on the periphery of the haptic 1015 are distributed to the base lens 1030 , rather than the power lens 1020 .
- the portion of the force that is distributed to the base lens 1030 does not significantly affect accommodation and/or power change, and therefore, is not utilized efficiently to effect power change by the accommodating IOL 1000 .
- the power lens 1020 By moving the power lens 1020 lower within the haptic 1015 , a greater proportion of forces are distributed to the power lens 1020 rather than being lost to the base lens 1030 . Furthermore, placement of the power lens 1020 proximate the base lens 1030 allows for the power lens 1020 to be in closer proximity with a hinge portion 1090 , which translates at least a portion of the forces being distributed to the base lens 1030 to the power lens 1020 .
- a cutout 1080 on a lower portion of a periphery of the power lens 1020 results in forces being translated to the membrane 1050 rather than the power lens optic 1040 .
- the haptic 1015 engages primarily with an upper portion 1070 of the periphery of the power lens 1020 and forces are exerted primarily on the membrane 1050 (which is on the upper portion of the power lens 1020 ) rather than the power lens optic 1040 (which is on the lower portion of the power lens 1020 ), thereby affecting greater power change in the power lens 1020 .
- the accommodating intraocular lens may have a higher profile as compared to the embodiments depicted in FIGS. 9 and 10 .
- the power lens in the high profile embodiments, is positioned closer to the open end of the haptic system 810 and farther away from the base lens 830 ( FIGS. 8 A- 8 C ) and in the low profile embodiments, the power lens 920 , 1020 is placed farther away from the open end and closer to the base lens 940 , 1030 ( FIGS. 9 A- 9 C and FIGS. 10 A- 10 D ).
- the position of the power lens is represented in FIGS. 8 C and 10 D with reference to the distance h 1 of the peripheral edge of the power lens from the first edge of the outer periphery of the haptic.
- the power lens is positioned at a predetermined distance from the first edge of the outer periphery of the haptic, as represented by h 1 in FIGS. 8 C and 10 D .
- the predetermined distance h 1 may be about 0 mm.
- the predetermined distance h 1 is may be provided within a range that is between and includes any two of the foregoing values.
- the predetermined distance h 1 for a high profile accommodating IOL may be in the range of about 0 mm to about 0.75 mm.
- the predetermined distance h 1 for a low profile accommodating IOL may be in the range of greater than 0.75 mm to about 1 mm.
- the predetermined distance h 1 may also be provided as a percentage of the total height h 2 of the outer periphery of the haptic system 810 , 1015 .
- the predetermined distance h 1 may be about 0.01%, about 1%, about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, and about 90% of the total height h 2 of the outer periphery of the haptic system 810 , 1015 .
- the predetermined distance h 1 may be provided within a range that is between and includes any two of the foregoing values.
- the predetermined distance h 1 for a high profile accommodating IOL may be about 0.01% to about 37% of the total height h 2 of the outer periphery of the haptic system 810 , 1015 . In yet a further aspect, the predetermined distance h 1 for a high profile accommodating IOL may be about 38% to about 75% of the total height h 2 of the outer periphery of the haptic system 810 , 1015 .
- FIG. 11 A depicts a perspective view of an accommodating IOL 1100 including a base assembly 1110 and a power lens 1120 , in accordance with an embodiment of the present disclosure.
- FIG. 11 B provides an exploded view of the accommodating IOL 1100
- FIG. 11 C provides a top plan view of the accommodating IOL 1100
- FIG. 11 D provides a cross-sectional view of the accommodating IOL 1100 .
- the base assembly 1110 includes a haptic system 1130 .
- the haptic system 1130 includes a plurality of recesses or cutouts 1140 defined within an inner periphery of the haptic system 1130 for receiving one or more fins 1150 extending from a peripheral edge of the power lens 1120 .
- the plurality of recesses or cutouts 1140 may be defined by a raised portion or tab 1160 and an entry passage on at least one side of the raised portion.
- the power lens 1120 is lowered into the base assembly 1110 such that each of the fins 1150 enter in through one of the plurality of cutouts 1140 .
- the power lens 1120 is then rotated, such that each fin 1150 is no longer positioned within one of the cutouts 1140 , but rather, is positioned below one of a plurality of tabs 1160 .
- the power lens 1120 becomes secured to the base assembly 1110 .
- manipulation holes may be created on the power lens 1120 to allow a user to insert a tool into the one or more manipulation holes to assist in rotating the power lens 1120 .
- FIGS. 12 A- 12 F provide various views of an accommodating IOL 1200 , according to an embodiment of the present disclosure.
- the accommodating IOL 1200 comprises a base assembly 1210 and a power lens 1220 .
- the base assembly 1210 includes abase lens 1290 .
- the power lens 1220 includes a flexible membrane 1230 and an optic 1235 and flanges 1240 that extend outwardly from a peripheral edge of the power lens 1220 .
- the flanges 1240 can be inserted into a channel 1250 that is formed in the inner periphery of the base assembly 1240 or haptic by a plurality of upper tabs 1260 and lower tabs 1270 .
- the positioning of the flanges 1240 towards the anterior portion of the power lens 1220 may be advantageous in that the flanges 1240 and the tabs 1260 securing the flanges 1240 are positioned such that they do not interfere with the visual elements of the accommodating IOL, i.e., the flexible membrane 1230 , the optic 1235 , and the base lens 1290 . As such, visual artifacts or light distortions caused by the flanges and the tabs 1260 , 1270 are minimized or eliminated altogether.
- the flanges 1240 do not extend out of the power lens 1220 at regions 1280 to allow for easier insertion of the power lens 1220 into the base assembly 1210 .
- FIGS. 13 A- 13 C depict an embodiment a base assembly 1300 with extended tabs for an accommodating IOL.
- the base assembly 1300 includes a haptic system 1310 and a cavity 1320 for receiving a power lens.
- Extended tabs 1330 extend over a portion of the circumference of the haptic system 1310 and into the cavity. The extended tabs 1330 are used to secure a power lens within the base assembly 1310 .
- each tab 1330 may be measured by an angular coverage, indicative of the portion of the circumference encompassed by each tab 1330 .
- each tab 1330 may encompass between 30 degrees and 180 degrees.
- Each tab 1330 may also include a width measurement, indicative of how far in towards the center of the base assembly the tab 1330 extends.
- An outer edge of the haptic system 1310 and applicable haptic systems described in this disclosure can be approximately 1 mm thick.
- FIGS. 14 A-D depict various views of an astigmatism-free base ring 1400 , in accordance with an embodiment of the present disclosure.
- the astigmatism-free base ring 1400 is a fluid-filled base ring configured to receive a power lens in a manner as depicted with reference to FIGS. 1 C and 3 C .
- the astigmatism-free base ring 1400 includes a haptic system 1410 and may be provided as a ring shaped to enclose a region 1420 .
- a power lens may be inserted into the reg 10 n 1420 to form an accommodating IOL.
- the astigmatism-free base ring 1400 includes upper flanges 1430 and a lower surface 1435 to secure the power lens between the upper flanges 1430 and the lower surface 1435 .
- FIG. 14 C provides a cross-sectional view of the astigmatic free base ring 1400 .
- the astigmatism-free base ring 1400 may include an outer reservoir 1440 and an inner reservoir 1450 .
- the outer reservoir 1440 and the inner reservoir 1450 may contain a fluid, and may be in fluid communication with one another.
- the outer reservoir 1440 and the inner reservoir 1450 may be provided in fluid communication with one another through a channel 1460 that is narrower than at least one of the outer reservoir 1440 and the inner reservoir 1450 .
- the use of the two reservoirs 1440 , 1450 in fluid communication with one other through a narrowed channel 1460 more evenly distributes a radially-compressive force onto the inner surface of the base ring 1400 that is located between the upper flange 1420 and the lower surface 1435 when a radially compressive force applied to the periphery of the haptic system 1410 . As such, a more even, non-toric deformation is created in the accommodating IOL.
- FIG. 14 D provides a cross-sectional view of an alternative embodiment of the astigmatism-free base ring 1400 .
- a mesh braid such as that shown in FIG. 14 E , may be incorporated into the inner reservoir 1450 .
- the mesh braid may comprise a Nitinol braid.
- the mesh braid ( FIG. 14 E ) may allow for fluid to flow between the inner and outer reservoirs 1450 , 1440 , while providing additional structure support for the inner reservoir, thereby facilitating even disbursement of forces applied to the astigmatism-free base ring 1400 .
- the base ring 1400 described above may further comprise a porous support structure or a mesh braid, such as the one depicted in FIG. 14 E , which may be disposed along a portion of or along an entirety of the inner reservoir 1450 .
- FIG. 15 A depicts a perspective view of an accommodating IOL 1500 having a base assembly and power lens that is attached or attachable to one another by bonding or insert molding.
- FIG. 15 B provides a top plan view of the accommodating IOL 1500 .
- FIG. 15 C depicts a cross-sectional view of the accommodating IOL 1500 .
- FIG. 15 D depicts a bottom perspective view of the accommodating IOL 1500 .
- the accommodating IOL 1500 includes a haptic base assembly 1510 attached to a power lens 1520 during manufacture.
- the attachment may be effectuated by one or both of bonding or insert molding, in which one of the base assembly 1510 and the power lens 1520 is molded and then the other of the base assembly 1510 and the power lens 1520 is molded directly onto the first molded part (i.e., the base assembly 1510 or the power lens 1520 ).
- the portion of the power lens 1520 that is attached to the base assembly 1510 may be one or both of a portion of the circumferential peripheral edge 1522 or a posterior edge 1524 of the power lens 1520 .
- the entire accommodating IOL 1500 can then be inserted into a patient.
- the accommodating IOL 1500 can include just a single optic, such that power correction comes only from the power lens 1520 .
- the base assembly 1510 itself does not comprise an optic that provides refractive correction and the IOL 1500 only comprises the power lens 1520 to provide refractive correction.
- FIGS. 16 A-F depict various views a no gap accommodating IOL 1600 including a gapless base assembly 1610 and a power lens 1620 .
- the gapless base assembly 1610 includes a base lens 1630 and a haptic system 1640 .
- the base lens 1630 and the haptic system 1104 are secured together so no gaps are formed leading into the power lens 1620 . This limits the ability of cells to flow into a cavity 1670 between the base lens 1630 and the power lens 1620 when a power lens 1620 is inserted into the gapless base assembly 1610 .
- a similar effect may be had by applying a Parylene coating a base assembly having gaps to prevent cell migration into and out of the cavity between the power lens and the base lens.
- the base assemblies described in this paper can provide a portion of power correction.
- a base assembly can be installed and an appropriate power lens to install can be selected to allow for correction within 1 ⁇ 4 of a diopter.
- an optic of the base assemblies can include a UV absorber or UV absorbent coating to absorb UV entering the eye of the patient.
- Purkinje images can be used to adjust a power lens or a base assembly to ensure that they are properly installed during the installation of the accommodating IOL.
- the two-part accommodating IOLs disclosed herein allow for greater efficiency in cataloguing products.
- 4 base assemblies and 9 power lenses are needed to cover a range of 12 to 27.5 diopters at half diopter steps.
- Using single lenses requires 32 different lenses.
- SKUs stock keeping units
- the tabs and the flanges of the base assemblies discussed in this paper can be colored differently than a power lens to allow a surgeon to see when a power lens has been correctly inserted into a base assembly.
- a power lens or an edge of a power lens can be colored to further aid in insertion of the power lens into a base assembly.
- a base lens or a haptic system of a base assembly can be colored. Coloration can be achieved by adding roughness or a coating to outer surfaces of any of the previously described components.
- Purkinje images may be utilized to assist in adjustment and placement of a power lens into a base assembly. Images can be used to adjust the power lens and base lens after implantation to assure the best fit. This approach gives immediate and simple feedback for the surgeon through the eye piece of a scope. For example, a surgeon can receive an indication that a power lens is correctly placed into a base lens if the surgeon can see a perfect circle when looking through the scope. If the circle is deformed or misshaped at all, the surgeon will know that they have to continue adjusting the power lens.
Abstract
An accommodating intraocular lens device is provided. The accommodating intraocular lens device comprises a base assembly and a power lens. The base assembly comprises a first open end, a second end coupled to a base lens, and a haptic surrounding a central cavity. The haptic may comprise an outer periphery, an inner surface and a height between a first edge and a second edge. The power lens is configured to fit within the central cavity. The power lens may comprise a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid. The first side of the power lens may be positioned at a predetermined distance from the first edge of the haptic.
Description
- The present application is a continuation of U.S. application Ser. No. 17/305,200, filed on Jul. 1, 2021, which is a continuation of U.S. application Ser. No. 15/996,188, now U.S. Pat. No. 11,065,107, filed on Jun. 1, 2018, which is a continuation of International Patent App. No. PCT/US2016/064491, filed on Dec. 1, 2016, which claims the benefit of U.S. Provisional Application No. 62/261,790, filed Dec. 1, 2015, the contents of each of which are incorporated herein by reference in their entireties. Any and all applications for which a foreign or domestic priority claim is identified in the Application Data Sheet as filed with the present application are hereby incorporated by reference.
- The invention relates generally to an accommodating intraocular lens device and, more particularly, to an accommodating intraocular lens device configured for implantation in a lens capsule or sulcus of a subject's eye.
- Surgical procedures on the eye have been on the rise as technological advances permit for sophisticated interventions to address a wide variety of ophthalmic conditions. Patient acceptance has increased over the last twenty years as such procedures have proven to be generally safe and to produce results that significantly improve patient quality of life.
- Cataract surgery remains one of the most common surgical procedures, with over 16 million cataract procedures being performed worldwide. It is expected that this number will continue to increase as average life expectancies continue to rise. Cataracts are typically treated by removing the crystalline lens from the eye and implanting an intraocular lens (“IOL”) in its place. As conventional IOL devices are primarily focused for distance visions, they fail to correct for presbyopia and reading glasses are still required. Thus, while patients who undergo a standard IOL implantation no longer experience clouding from cataracts, they are unable to accommodate, or change focus from near to far, from far to near, and to distances in between.
- Surgeries to correct refractive errors of the eye have also become extremely common, of which LASIK enjoys substantial popularity with over 700,000 procedures being performed per year. Given the high prevalence of refractive errors and the relative safety and effectiveness of this procedure, more and more people are expected to tum to LASIK or other surgical procedures over conventional eyeglasses or contact lens. Despite the success of LASIK in treating myopia, there remains an unmet need for an effective surgical intervention to correct for presbyopia, which cannot be treated by conventional LASIK procedures.
- As nearly every cataract patient also suffers from presbyopia, there is convergence of market demands for the treatment of both these conditions. While there is a general acceptance among physicians and patients of having implantable intraocular lens in the treatment of cataracts, similar procedures to correct for presbyopia represent only 5% of the U.S. cataract market. There is therefore a need to address both ophthalmic cataracts and/or presbyopia in the growing aging population.
- In one embodiment, an accommodating intraocular lens device having one of a high profile or a low profile. The accommodating intraocular lens device may comprise a base assembly and a power lens. The base assembly may comprise a first open end, a second end coupled to a base lens, and a haptic surrounding a central cavity. The haptic may comprise an outer periphery, an inner surface and a height between a first edge and a second edge. The power lens may comprise a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid. The power lens may be configured to fit within the central cavity. The first side of the power lens may be positioned at a predetermined distance from the first edge of the haptic.
- In one optional aspect, the accommodating intraocular lens may have a high profile, with the predetermined distance being in the range of about 0 mm to about 0.75 mm In another optional aspect, the predetermined distance may be about 0.01% to about 37% of the height of the outer periphery.
- In another optional aspect, the accommodating intraocular lens may have a low profile, with the predetermined distance being in the range of about 0.75 mm to about 1.5 mm In a further optional aspect, the predetermined distance may be about 38% to about 75% of the height of the outer periphery.
- In another optional aspect, the inner surface of the haptic may face the central cavity and the inner surface may comprise a plurality of spaced apart contact points configured to engage a portion of the peripheral edge of the power lens.
- In another optional aspect, outer grooves may be provided to extend along at least a portion of the height of the haptic. The outer grooves may be configured to permit the haptic to be radially compressed, radially expanded, or both. The outer grooves may be disposed in the outer periphery opposite the inner surface contact points.
- In another optional aspect, the haptic may further comprise a plurality of tabs extending radially inwardly into the cavity. The power lens may be secured to the base assembly by the plurality of tabs. In one aspect, the plurality of tabs comprise a bottom surface that is configured to contact the first side of the power lens. The bottom surface of the plurality of tabs may be positioned at a distance of about 0 mm to about 0.75 mm from the first edge of the haptic. The bottom surface of the tabs may also be provided at a distance, from the first edge of the haptic, of about 0.01% to about 37% of the height of the haptic. In another aspect, the bottom surface of the plurality of tabs may be positioned at a distance of about 0.75 mm to about I mm from the first edge of the haptic. The bottom surface of the tabs may also be provided at a distance, from the first edge of the haptic, of about 38% to about 75% of the height of the haptic.
- In another optional aspect, the haptic may further comprise a plurality of tables extending radially inwardly into the cavity. A channel may be formed between the plurality of tabs and the plurality of tables to secure the power lens to the base assembly.
- In another optional aspect, the accommodating intraocular lens device may further comprise a plurality of arms coupling the base lens to the haptic. The plurality of arms may vault the base lens away from the central cavity.
- In another optional aspect, the first side of the power lens may comprise one of a flexible membrane and an optic and the second side of the power lens may comprise the other of the flexible membrane and the optic. The power lens may further comprise an optic coupler disposed from the peripheral edge to couple the optic to the peripheral edge. The optic coupler may be angled to vault the optic toward the flexible membrane.
- In another optional aspect, the fluid contained in the closed cavity of the power lens may be one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.
- In another embodiment, an accommodating intraocular lens device is provided. The accommodating intraocular lens device may comprise a base and a power lens. The base may comprise an outer portion, an inner portion and a closed space defined between the outer and inner portions. The closed space may comprise a reservoir configured to contain a fluid. The inner portion may circumscribe a substantially circular space. The power lens may comprise a flexible membrane on one side, an optic on the opposing side and a circumferential peripheral edge coupling the flexible membrane and the optic. A portion of the circumferential peripheral edge may be configured to be in facing relation to at least a portion of the inner portion of the base.
- In one optional aspect, the base may be shaped as a ring.
- In another optional aspect, the base may comprise a base lens.
- In another optional aspect, the base may be shaped as an incomplete ring having two closed ends. The reservoir may extend around a portion of the circumference of the base at an arc degree of about 90 to about 350.
- In another optional aspect, a thickness of the inner portion is less than a thickness of the outer portion.
- In another optional aspect, the reservoir contains a fluid. The fluid may be any one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.
- In another optional aspect, the power lens may further comprise a membrane coupler extending radially inwardly from the circumferential edge to couple the membrane with the peripheral edge.
- In another optional aspect, the power lens may further comprise an optic coupler disposed from the circumferential peripheral edge to couple the optic to the peripheral edge. The optic coupler is angled to vault the optic toward the flexible membrane.
- In another optional aspect, the base may further comprise upper and lower flanges extending radially inwardly and forming a channel adapted to accommodate the peripheral edge of the power lens.
- In another optional aspect, the reservoir may comprise an outer reservoir, an inner reservoir and a narrowed channel between the outer and the inner reservoir. The inner reservoir may comprise a support structure or a braided structure.
- In another optional aspect, the circumferential peripheral edge facing the inner portion of the base may be in direct physical contact with the inner portion.
- In another optional aspect, the flexible membrane, the optic and the circumferential peripheral edge define a closed cavity within the power lens. The closed cavity may be configured to contain a fluid. The fluid may be any one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.
- In another embodiment, a toric base assembly for an accommodating intraocular lens device is provided. The toric base assembly can be used as a part of a two-part accommodating intraocular lens device that further includes a power lens that can be provided in connection with the toric base assembly. The toric base assembly provides for an asymmetric translation of a radially compressive force onto a power lens that is provided centrally within the toric base assembly. The toric base assembly may thus comprise a base assembly comprising a base lens and a substantially circular haptic surrounding the base lens. The substantially circular haptic may have an outer periphery and at least one region in which the flexibility of the haptic is greater than the flexibility in remaining regions of the haptic. Application of a radially compressive force may result in an asymmetric deformation of the substantially circular haptic and the asymmetric deformation of the substantially circular haptic may provide a toric power change in one or both of the base lens and the power lens.
- In one optional aspect, the at least one region may comprise two regions on opposing sides of the substantially circular haptic.
- In another optional aspect, the greater structural flexibility may be provided by reducing a thickness of the at least one region.
- In another optional aspect, the greater structural flexibility may be provided by forming one or more shaped cut-outs in the circular haptic in the at least one region.
- In another optional aspect, the circular haptic may comprise at least one portion that extends radially outwardly of the outer periphery.
- In another optional aspect, the circular haptic may comprise two portions that extend radially outwardly of the outer periphery. The two regions may be on opposing sides of the circular haptic.
- In another optional aspect, in the at least one region, the substantially circular haptic may comprise at least one portion that extends radially outwardly of the outer periphery.
- In another optional aspect, the accommodating intraocular lens device may further comprise one or more tabs extending radially inwardly from the outer periphery.
- In another optional aspect, the accommodating intraocular lens device may further comprise a power lens configured to engage the circular haptic.
- In another optional aspect, the asymmetric deformation of the substantially circular haptic provides a toric power change in both of the base lens and the power lens.
- In another embodiment, an accommodating intraocular lens device may be provided with a retaining system that permits the power lens and the base assembly to couple or interlock. The accommodating intraocular lens device may comprise a base assembly comprising a first open end, a second end comprising a base lens, and a haptic surrounding the base lens. The haptic may comprise an outer periphery surrounding a cavity. A power lens may be sized to fit within the cavity and a retaining system may be provided to secure the power lens within the cavity.
- In one optional aspect, the retaining system may comprise a plurality of tabs extending radially inwardly from the haptic and into the cavity.
- In another optional aspect, the retaining system may comprise a plurality of fins extending from a peripheral edge of the power lens and a plurality of corresponding recesses defined within an inner periphery of the haptic. The plurality of recesses may each be defined by a raised portion and an entry passage on at least one side of the raised portion.
- In another optional aspect, the retaining system may comprise a pair of flanges extending outwardly from a peripheral edge of the power lens and a channel. The channel may be formed in the inner periphery of the haptic. The channel may also be formed between a pair of opposing tabs extending from the inner periphery of the haptic.
- In another optional aspect, the retaining system may comprise a plurality of tabs that extend radially inwardly from the first open end of the base assembly.
- In another optional aspect, the haptic is substantially circular.
- In another embodiment, an accommodating intraocular lens device is provided in which the power lens is attachable or attached to a base assembly. The accommodating intraocular lens device may comprise a base assembly and a power lens. The base assembly may comprise a first open end, an open second end, and a substantially circular haptic surrounding the base lens. The substantially circular haptic may comprise an outer periphery and an inner periphery facing a cavity. The power lens may be sized to fit within the cavity. The power lens may comprise a circumferential peripheral edge, wherein at least a portion of the circumferential peripheral edge may be engaged with the inner periphery of the substantially circular haptic.
- In one optional aspect, the base assembly does not comprise an optic or lens in addition to the power lens.
- In another optional aspect, a portion of the power lens may be attached to the substantially circular haptic. The portion of the power lens that is attached to the substantially circular haptic may be one or both of the circumferential peripheral edge or the posterior edge of the power lens.
- In another optional aspect, the power lens may be attached to the substantially circular haptic by one or a combination selected from the group consisting of: bonding and insert-molding.
- Other objects, features and advantages of the described preferred embodiments will become apparent to those skilled in the art from the following detailed description. It is to be understood, however, that the detailed description and specific examples, while indicating preferred embodiments of the present invention, are given by way of illustration and not limitation. Many changes and modifications within the scope of the present invention may be made without departing from the spirit thereof, and the invention includes all such modifications.
- Illustrative embodiments of the present disclosure are described herein with reference to the accompanying drawings, in which:
-
FIG. 1A depicts a perspective view of a fluid-filled base assembly, in accordance with an embodiment of the present disclosure. -
FIG. 1B depicts a cross-sectional view of the fluid-filled base assembly ofFIG. 1A . -
FIG. 1C depicts an exploded perspective view of a power lens being inserted into the fluid-filled base assembly ofFIG. 1A -
FIG. 2A depicts a perspective view of a fluid-filled open base ring, in accordance with an embodiment of the present disclosure. -
FIG. 2B depicts a top plan view of the fluid-filled open base ring ofFIG. 2A . -
FIG. 2C depicts a cross-sectional view of the fluid-filled open base ring ofFIG. 2A . -
FIG. 3A depicts a perspective view of a fluid-filled closed base ring, in accordance with an embodiment of the present disclosure. -
FIG. 3B depicts a top plan view of the fluid-filled closed base ring ofFIG. 3A . -
FIG. 3C depicts an exploded perspective view of a power lens coupled to the fluid-filled closed base ring ofFIG. 3A . -
FIG. 4A depicts a perspective view of a power lens coupled to a fluid-filled closed base ring, in accordance with an embodiment of the present disclosure. -
FIG. 4B depicts a perspective view of a power lens coupled to a fluid-filled open base ring, in accordance with an embodiment of the present disclosure. -
FIG. 5A depicts a perspective view of a power lens having a fluid transfer system, in accordance with an embodiment of the present disclosure. -
FIG. 5B is a close up view of a fluid transfer system, in accordance with an embodiment of the present disclosure. -
FIG. 6A depicts a perspective view of a toric base assembly, in accordance with an embodiment of the present disclosure. -
FIG. 6B depicts a top plan view of the toric base assembly ofFIG. 6A . -
FIG. 7A depicts a perspective view of a toric base assembly, in accordance with an embodiment of the present disclosure. -
FIG. 7B depicts a top plan view of the toric base assembly ofFIG. 7A . -
FIG. 8A depicts a perspective view of a base assembly, in accordance with an embodiment of the present disclosure. -
FIG. 8B depicts a top plan view of the base assembly ofFIG. 8A . -
FIG. 8C depicts a cross-sectional view of the base assembly ofFIG. 8A . -
FIG. 9A depicts a perspective view of an accommodating IOL configured to position a power lens closer to a base lens of the base assembly, in accordance with an embodiment of the present disclosure. -
FIG. 9B depicts a top plan view of the accommodating IOL ofFIG. 9A . -
FIG. 9C depicts a cross-sectional view of the accommodating IOL ofFIG. 9A . -
FIG. 10A depicts an exploded perspective view of a low profile accommodating IOL, in accordance with an embodiment of the present disclosure. -
FIG. 10B depicts a perspective view of the low profile accommodating IOL ofFIG. 10A . -
FIG. 10C depicts a top plan view of the low profile accommodating IOL ofFIG. 10A . -
FIG. 10D depicts a perspective cross-sectional view of the low profile accommodating IOL ofFIG. 10A . -
FIG. 11A depicts a perspective view of an accommodating IOL comprising a base assembly and a power lens having a fin-lock, in accordance with an embodiment of the present disclosure. -
FIG. 11B depicts an exploded perspective view of the accommodating IOL ofFIG. 11A -
FIG. 11C depicts a top plan view of the accommodating IOL ofFIG. 11A -
FIG. 11D depicts a cross-sectional view of the accommodating IOL ofFIG. 11A -
FIG. 12A depicts an exploded perspective view of an accommodating IOL having a base assembly and a power lens with a plate haptic, in accordance with an embodiment of the present disclosure. -
FIG. 12B depicts an exploded plan view of the accommodating IOL ofFIG. 12A . -
FIG. 12C depicts a top plan view of the power lens of the accommodating IOL ofFIG. 12A . -
FIG. 12D depicts a top plan view of the accommodating IOL ofFIG. 12A . -
FIG. 12E depicts a cross-section view of the accommodating IOL ofFIG. 12A . -
FIG. 12F depicts a bottom perspective view of the accommodating IOL ofFIG. 12A . -
FIG. 13A depicts a perspective view of a base assembly having extended tabs, m accordance with an embodiment of the present disclosure. -
FIG. 13B depicts a top plan view of the base assembly ofFIG. 13A . -
FIG. 13C depicts a cross-sectional view of the base assembly ofFIG. 13A . -
FIG. 14A depicts a perspective view of a base ring, in accordance with an embodiment of the present disclosure. -
FIG. 14B depicts a top plan view of the base ring ofFIG. 14A . -
FIG. 14C depicts a cross-sectional view of the base ring ofFIG. 14A . -
FIG. 14D depicts an alternative cross-sectional view of the base ring ofFIG. 14A . -
FIG. 14E depicts a perspective view of a mesh braid that may be incorporated into the base ring ofFIG. 14D . -
FIG. 15A depicts a perspective view of an accommodating IOL having a one-piece base assembly and a power lens, in accordance with an embodiment of the present disclosure. -
FIG. 15B depicts a top plan view of the accommodating IOL ofFIG. 15A -
FIG. 15C depicts a cross-sectional view of the accommodating IOL ofFIG. 15A -
FIG. 15D depicts a bottom perspective view of the accommodating IOL ofFIG. 15A -
FIG. 16A depicts a perspective view of an accommodating IOL having a no gap base assembly, in accordance with an embodiment of the present disclosure. -
FIG. 16B depicts a side plan view of the accommodating IOL ofFIG. 16A -
FIG. 16C depicts a perspective view of a no gap base assembly that may be utilized in the accommodating IOL ofFIG. 16A -
FIG. 16D depicts a perspective view of a power lens that may be utilized m the accommodating IOL ofFIG. 16A -
FIG. 16E depicts a top plan view of the accommodating IOL ofFIG. 16A -
FIG. 16F depicts a cross-sectional view of the accommodating IOL ofFIG. 16A Like numerals refer to like parts throughout the several views of the drawings. - Specific, non-limiting embodiments of the present invention will now be described with reference to the drawings. It should be understood that such embodiments are by way of example and are merely illustrative of but a small number of embodiments within the scope of the present invention. Various changes and modifications obvious to one skilled in the art to which the present invention pertains are deemed to be within the spirit, scope and contemplation of the present invention.
- Various embodiments of accommodating intraocular lenses (IOL) described herein and may comprise the power changing feature of a power lens in connection with a base lens. In one optional embodiment, the power changing feature of the IOL is driven by fluid optics within a closed volume of a power lens that comprises a flexible membrane and a lens or optic. One significant advantage of this embodiment is that the closed volume of the power lens that spaces apart the flexible membrane and the lens maintains a substantially constant volume and therefore avoids many of the problems associated with fluid optic IOLs that require substantial changes in volume, i.e., fluid being fed into the chamber from reservoirs. The many disadvantages exhibited by fluid optics having changing volumes include non-uniform power change and buckling. Certain embodiments of the IOLs and the power lens disclosed herein may avoid or mitigate such problems by maintaining a substantially constant volume, while at the same time maintaining good optical quality throughout the range of power change. Additionally, various embodiments of the IOLs that comprise a two-part assembly of the power lens and the base assembly as described herein provide a smaller delivery profile, a smaller implant profile or both, so as to require a substantially smaller incision size for implantation. This, in turn, may have the concomitant advantage of reducing biocompatibility issues associated with the delivery and implantation of larger IOLs and may result in faster healing and a more stable refraction.
- The IOLs disclosed herein may be configured in any number of ways. Generally, the IOLs may comprise a base assembly and a power lens that can be coupled within the base assembly. In one embodiment, the radially compressive forces exerted on an implanted IOL may be concentrated onto a flexible membrane of the power lens to cause the flexible membrane to change in curvature. The lens or optic of the power lens may be configured to axially displace toward the flexible membrane in response to its change in curvature. This axial displacement may be facilitated by coupling the optic to the peripheral edge of the IOL in a manner that permits the optic to float. As the flexible membrane of the power lens changes in curvature, fluid adhesion or surface tension may pull the optic or lens of the power lens toward the flexible membrane. In another embodiment, the radially compressive forces exerted on the power lens may be concentrated onto the optic to cause the optic to axially displace and to push the flexible membrane in the same direction as the axial displacement of the optic to effectuate the change in curvature of the flexible membrane. In yet a further embodiment, the radially compressive forces on the power lens may be exerted on both the optic and the flexible membrane to cause the axial displacement and change in curvature, respectively.
- In a further embodiment, the radially compressive forces exerted on the power lens may be applied to one or both of the flexible membrane and the optic to cause the change in curvature of the flexible membrane and to cause axial displacement of the optic toward the flexible membrane, while maintaining a constant volume during radial compression.
- In one embodiment, the term “constant volume” includes a volume which changes no more than about 1% from its resting state, no more than about 2% from its resting state, no more than about 3% from its resting state, no more than about 4% from its resting state, no more than about 5% from its resting state, no more than about 10% from its resting state, no more than about 15% from its resting state, no more than about 20% from its resting state, no more than about 25% from its resting state, no more than about 30% from its resting state, no more than about 35% from its resting state, no more than about 40% from its resting state, no more than about 45% from its resting state, no more than about 50% from its resting state, no more than about 55% from its resting state, no more than about 60% from its resting state, no more than about 65% from its resting state, no more than about 70% from its resting state, and no more than about 75% from its resting state. In another embodiment, the term “constant volume” refers to a volume that changes in a range that includes and is between any two of the foregoing values. The term “resting state” describes the configuration of the IOL or power lens when no radially compressive forces are exerted on the IOL or the power lens.
- As used herein, the term “power lens” may refer to an assembly that provides a range of accommodation or refractive correction in response to the application of radially compressive or expansive forces. In one embodiment, the power lens may provide a range of accommodation of about 1 diopter, about 2 diopters, about 3 diopters, about 4 diopters, about 5 diopters, about 6 diopters, about 7 diopters, about 8 diopters, about 9 diopters, about 10 diopters, about 11 diopters, about 12 diopters, about 13 diopters, about 14 diopters, about 15 diopters, about 16 diopters, about 17 diopters, about 18 diopters, about 19 diopters, or about 20 diopters. In another embodiment, the power lens may provide a range of accommodation between and including any two of the foregoing values. The term “power lens” may also include an assembly which comprises a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid. In one aspect, the first and second sides may be a flexible membrane or an optic. In another aspect, the first side may be one of a flexible membrane or an optic and the second side may be the other of a flexible membrane or an optic. In a further aspect, the power lens may further be characterized as having a closed fluid-filled cavity having a constant volume throughout the range of accommodation.
- Certain embodiments of the two-part accommodating IOL devices disclosed herein may provide a number of advantages owing to their separate two-part construction. Implantation of the two-part IOL device may require a significantly reduced incision size, as the two parts of the IOL device (e.g., the base assembly and the power lens) are implanted separately and thus significantly reducing the delivery profile for implantation. The reduced incision size may provide a number of advantages, including obviating the need for anesthesia and sutures to close the incision site and improved surgical outcomes. In one embodiment, the incision size required to implant the two-part accommodating IOL devices is less than about 5 mm, less than about 4 mm, less than about 3 mm, or less than about 2 mm Stated a different way, each part of the two-part accommodating IOL device may be provided in a delivery state having a delivery profile that is less than about 5 mm, less than about 4 mm, less than about 3 mm, or less than about 2 mm The delivery state of each part of the two-part accommodating IOL device may be provided when each part is rolled, folded or otherwise compressed to reduce its size for delivery. A hinge or a predetermined crease may be provided on one or both of the base assembly and the power lens to facilitate folding or rolling into the delivery state.
- Additionally, greater control is afforded with respect to adjusting the sizing and the power of the IOL during surgery. Implanting the base assembly into the lens capsule will provide the physician an impression as to the size of the patient's lens capsule and will thus help select the correct size of the power changing lens that will subsequently be implanted into the base assembly.
-
FIG. 1A depicts a perspective of an embodiment of a fluid-filledbase assembly 100 of an accommodating IOL.FIG. 1B provides a cross-sectional view of the fluid-filledbase assembly 100. Thebase assembly 100 shown inFIGS. 1A-1B may include abase lens 110 and ahaptic system 120 disposed substantially circumferentially around thebase lens 110. Thehaptic system 120 may be sized and configured to receive a separate power lens, such as thepower lens FIGS. 1C and 3C respectively. Thepower lens base assembly 100 to form a two-part accommodating IOL device. - In one embodiment, the
haptic system 120 may include areservoir 130 that extends through at least a portion of thehaptic system 120. In accordance with one aspect, thereservoir 130 can extend around a portion of the circumference of thehaptic system 120, as depicted inFIGS. 2A-2C and 4B , such that thereservoir 130 has an arc degree of at least 90, at least 100, at least 110, at least 120, at least 130, at least 140, at least 150, at least 160, at least 170, at least 180, at least 190, at least 200, at least 210, at least 220, at least 230, at least 240, at least 250, at least 260, at least 270, at least 280, at least 290, at least 300, at least 310, at least 320, at least 330, at least 340, at least 350, or about 360. In accordance with another aspect, thereservoir 130 can extend around a portion of the circumference of thehaptic system 120 within a range that includes and is between any two of the foregoing values, e.g. 180 arc degrees to 270 arc degrees. In accordance with another aspect, thereservoir 130 can extend around an entire circumference of thehaptic system 120, e.g., 360 arc degrees, as provided in the embodiment depicted inFIGS. 1A-1C . - The
reservoir 130 can be defined or bounded by aninner region 180 andouter region 150. Thereservoir 130 is configured to contain a fluid (e.g., a liquid or a gas). In certain embodiments, the fluid can be selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether. The fluid contained within thereservoir 130 can function to distribute forces applied to theouter region 150 of thehaptic system 120 to theinner region 180. For example, fluid contained within thereservoir 130 can be used to substantially evenly transmit compressive forces applied to theouter region 150 of thehaptic system 120, e.g. forces caused from the relaxation of the ciliary muscles, to theinner region 180. Forces transmitted to theinner region 180 can subsequently be transmitted to a power lens (195, 350 as depicted inFIGS. 1C and 3C respectively) that is coupled centrally within thebase assembly 100. Alternatively or in addition, forces transmitted to theinner region 180 can be transmitted to thebase lens 110. - The fluid-filled
base assembly 100 can include anupper flange 160 and alower flange 170 extending inwardly from thehaptic system 120 along at least a portion of the circumference of thehaptic system 120. Theupper flange 160 and thelower flange 170 define a channel that is configured to secure apower lens 195 to the fluid-filledbase assembly 100.FIG. 1C depicts an exploded perspective view of apower lens 195 being inserted into thebase assembly 100, with the peripheral edge 197 of thepower lens 195 being adapted to fit within the channel defined by the upper andlower flanges inner region 180 so as to effectively transmit the forces transmitted to theinner region 180 onto one or both of the first and second sides 196, 199 of thepower lens 195 to provide accommodation. As explained above, the first and second sides may be a flexible membrane or an optic or, alternatively, the first side may be one of a flexible membrane or an optic and the second side may be the other of a flexible membrane or an optic. -
FIG. 2A depicts a perspective view of an open fluid-filledbase ring 200 of an accommodating IOL.FIGS. 2B and 2C depict top plan and cross-sectional views of the open fluid-filledbase ring 200, respectively. The open fluid-filledbase ring 200 represents an alternative embodiment of the fluid-filledbase assembly 100 discussed above with reference toFIGS. 1A-1C and can be used in connection with thepower lens 195 depicted in relation toFIG. 1C . The open fluid-filledbase ring 200 includes ahaptic system 210. The open fluid-filledbase ring 200 differs from thebase assembly 100 ofFIG. 1 in that the open fluid-filledbase ring 200 does not include a base lens. As such, any visual correction must be provided by apower lens 195 that may be inserted into the open fluid-filledbase ring 200 in a manner depicted in relation toFIG. 1C . - In one embodiment, the open fluid-filled
base ring 200 is an open ring, i.e., it is not a complete ring. In one embodiment, the open fluid-filledbase ring 200 is provided as a C-shape having two closed ends, 210A, 210B, in which its outer periphery is less than 360 arc degrees. In another embodiment, the open fluid filledbase ring 200 is provided as a circular shape of substantially about 360 arc degrees but comprises a pair of closed ends such that theinner cavity 250 is not a continuous circumferential volume but comprises a circumferential volume having a pair of closed ends. Both embodiments permit for the open fluid-filledbase ring 200 to increase the diameter defined within the central area of the haptic 210 and accommodate power lenses of varying diameters. The C-shaped or incomplete ring configuration can also allow for toric or non-uniform deformation of a power lens, as a portion of the periphery of the power lens will not be contacted by the open fluid-filledbase ring 200 and, therefore, the uncontacted portion of the periphery of the power lens will not experience radially-inward forces applied by the open fluid-filledbase ring 200. Thus in one embodiment, the open fluid-filledbase ring 200 can transmit a radially-compressive forces around only a pre-determined portion of the circumference of apower lens 195 peripheral edge 197 that is provided or coupled within the open fluid-filledbase ring 200 so as to provide an asymmetric radial compression of thepower lens 195 implanted within the open fluid-filledbase ring 200. - In one embodiment, the open fluid-filled
base ring 200 has an arc degree of at least 180, at least 190, at least 200, at least 210, at least 220, at least 230, at least 240, at least 250, at least 260, at least 270, at least 280, at least 290, at least 300 at least 310, at least 320, at least 330, at least 340, at least 350, or 360. In each of the foregoing embodiments, the open-fluid filled base ring has a circumference that defines an angle that is provided within a range between any two of the foregoing values. - The open fluid-filled
base ring 200 includes upper andlower flanges channel 240 therebetween. Thechannel 240 may be configured to receive and secure the power lens. Thehaptic system 210 includes a reservoir 250 (seeFIG. 2C ) that extends through at least a portion of thehaptic system 210, e.g. around substantially the entirehaptic system 210. Thehaptic system 210 may include aninner wall 260 and anouter wall 270 that define thereservoir 250. In one embodiment, theinner wall 260 may have a thickness that is less than a thickness of theouter wall 270. The thickness of theinner wall 260 may be about 90%, about 80%, about 70%, about 60%, about 50%, about 40%, about 30%, about 20%, about 10% and about 5% of the thickness of theouter wall 270. The thickness of theinner wall 260 may also be within a range that is between and includes any two of the foregoing values. - The
reservoir 250 may be configured to contain a fluid. In certain embodiments, the fluid may be selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether. The fluid contained within thereservoir 250 may function to distribute forces applied to theouter wall 270 of thehaptic system 210 to theinner wall 240. For example, the fluid contained within thereservoir 250 may be used to substantially evenly transmit compressive forces applied to a periphery of thehaptic system 210, e.g. forces caused from the contraction and/or relaxation of the ciliary muscles. Forces transmitted to theinner wall 260 may subsequently be transmitted to a power lens contained within thechannel 240. -
FIG. 3A depicts a perspective view of a fluid-filledbase ring 300, in accordance with another embodiment of the present disclosure.FIG. 3B is a top plan view of the fluid-filledbase ring 300. The fluid-filledbase ring 300 is substantially similar to the open fluid-filledbase ring 200 ofFIGS. 2A-C , with the primary difference being that the fluid-filledbase ring 300 is a closed ring, rather than an open ring. The fluid-filledbase ring 300 may also include ahaptic system 310 that is ring shaped. The fluid-filledbase ring 300 may also include anupper flange 320 and alower flange 330 extending radially inwardly from thehaptic system 310. Theupper flange 320 and thelower flange 330 together define a channel that is configured to secure a power lens within a central portion of the fluid-filledbase ring 300. Aninner wall 340 is defined between theupper flange 320 and thelower flange 330. As described above with the embodiments ofFIGS. 1 and 2 , external forces applied to the outer wall of the haptic system 310 (e.g., by the ciliary muscles of an eye) can be translated through the fluid-filledbase ring 300 to theinner wall 340 of the haptic system 310 (the channel) to apply forces to a power lens inserted into the channel. -
FIG. 3C depicts an exploded perspective view of apower lens 350 that is configured to be coupled to the fluid-filledbase ring 300. The fluid-filledbase ring 300 is configured to secure thepower lens 350 to form an accommodating IOL. - In various embodiments, the
power lens 350 includes aflexible membrane 352 on one side, an optic 354 on the opposing side, and a circumferentialperipheral edge 358 coupling the flexible membrane and the optic 354. Amembrane coupler 356 can extend radially inwardly from the internal side of the circumferentialperipheral edge 358 to couple themembrane 352 to theperipheral edge 358. In accordance with one optional aspect, at least a portion of theperipheral edge 358 is in direct contact with theinner wall 340 of the fluid-filledbase ring 300. In accordance with another optional aspect, the entirety of theperipheral edge 358 is in direct contact with theinner wall 340 of the fluid-filledbase ring 300. Thepower lens 350 can comprise anoptic coupler 360 extending radially inwardly from the internal side of the circumferentialperipheral edge 358 to couple the optic 354 to theperipheral edge 358. Preferably, theoptic coupler 360 is angled toward theflexible membrane 352 such that it vaults the optic 354 toward theflexible membrane 352. See, e.g.,power lens 920 ofFIG. 9C andpower lens 1020 ofFIG. 10D for exemplary cross-sectional views. Thus, in one embodiment, thepower lens 350 can be identical to thepower lens 920 ofFIG. 9C or thepower lens 1020 ofFIG. 10D . - Other examples of accommodating IOLs are disclosed in U.S. Patent Application Publication No. 2013/0053954, entitled Accommodating Intraocular Lens; U.S. Patent Application Publication No. 2014/0180403, entitled Accommodating Intraocular Lens; U.S. Patent Application Publication No. 2015/0105760, entitled Method and System for Adjusting the Refractive Power of an Implanted Intraocular Lens; and U.S. patent application Ser. No. 14/447,621, entitled Accommodating Intraocular Lens, the entire contents of which are incorporated by reference in their entirety as if fully set forth herein. Any of the features disclosed with respect to the accommodating intraocular lenses in the above-cited references may be applied to any of the base assemblies, the power lenses, or the accommodating IOLs disclosed herein. For example, the various one-piece accommodating IOL embodiments disclosed in U.S. Patent application Publication Nos. 2013/0053954, 2014/0180403, and 2015/0105760 can be utilized as the
power lens 350. U.S. patent application Ser. No. 14/447,621 discloses a two-piece accommodating IOL that utilizes a base assembly and a power lens inserted into the base assembly (sometimes referred to as an accommodating IOL or IOL). It should be understood that various embodiments are possible. -
FIG. 4A depicts a perspective view of apower lens 350 coupled to a fluid-filledbase ring 300.FIG. 4B depicts a perspective view of apower lens 350 coupled to an open fluid-filledbase ring 200. In accordance with one aspect, only at least a portion of the circumferentialperipheral edge 358 is in direct physical contact with theinner wall base ring 200, 300 (e.g.FIG. 4B ). In accordance with another aspect, the entirecircumferential edge 358 is in direct contact with theinner wall 340 of the fluid-filled base ring 300 (e.g.,FIG. 4A ). -
FIG. 5A provides a perspective view of a fluid-exchange power lens 500 in accordance with an embodiment of the present disclosure. Thepower lens 500 shown inFIG. 5A can include the components as described with respect to thepower lens 350 shown in, for example,FIG. 3C . In various embodiments, thepower lens 500 includes a reservoir for storing a fluid that can be transferred to a fluid-filled base assembly that forms part of an accommodating IOL. Thepower lens 500 includes afluid transfer valve 510 that is configured to be removably coupled to the fluid-filled base assembly (seeFIG. 5B ). Thefluid transfer valve 510 functions to provide a fluid communication between thepower lens 500 and a base assembly shown inFIGS. 1-4 . -
FIG. 5B depicts an embodiment of a fluid transfer system for transferring fluid between a power lens and a fluid-filled base assembly of an accommodating IOL. Thefluid transfer valve 510 is configured to interact with a receivingvalve 520 that is disposed on an inner wall of the fluid-filled base assembly (e.g., 180, 240, 340 ofFIGS. 1B, 2A, 3A , respectively. In various embodiments, thefluid transfer valve 510 can be implemented as part of apower lens 500 and the receivingvalve 520 can be implemented as part of a fluid-filledbase assembly 590 or vice versa. Thefluid transfer valve 510 includes acanal 530 leading to a one-way valve 540. The receivingvalve 520 includesvalve release canal 550. The receivingvalve 520 includes its own one-way valve 560. When thefluid transfer valve 510 and the receivingvalve 520 stand alone, both one-way valves power lens 500 or the fluid-filledbase assembly 590. When thecanal 530 of thefluid transfer valve 510 is inserted into the one-way valve 560 of the fluid-filledbase assembly 590, thecanal 530 forces open the one-way valve 560. Similarly, thevalve release canal 550 forces open the one-way valve 540. As a result, both one-way valves power lens 500 and the fluid-filledbase assembly 590. -
FIGS. 6 and 7 depict embodiments of atoric base assembly base assembly base lens haptic system greater flexibility haptic system haptic system haptic system greater flexibility greater flexibility haptic system base lens haptic system -
FIGS. 6A-6B depicts one embodiment of thetoric base assembly 600.FIG. 6A depicts a perspective view of atoric base assembly 600 of an accommodating toric IOL, in accordance with an embodiment of the present disclosure.FIG. 6B provides a top plan view of thetoric base assembly 600. Thetoric base assembly 600 includes abase lens 610 and substantially circularhaptic system 620. Thetoric base assembly 600 includes a plurality oftabs 630 to engage an inserted power lens (not depicted). The outer periphery of thehaptic system 620 is configured to receive deforming forces caused by the ciliary muscles of the eye to cause radially-inward compression of thehaptic system 620. These forces are then translated to either one or both of thebase lens 610 and/or a power lens that can be inserted into thebase assembly 600. In the embodiment shown inFIGS. 6A and 6B , portions of thehaptic system 620 have greater structural flexibility, leading to uneven translation of a radially-inwardly applied force by various portions of thehaptic system 620. In the embodiment shown,cutouts 640 are formed in thehaptic system 620 to create greater flexibility proximate thecutouts 640. Thecutouts 640 can be formed to provide an area of the haptic 620 that is thinner than the remaining areas of the haptic 620. As a result, greater compressive forces are applied by thehaptic system 620 proximate thecutouts 640, which in tum results in toric deformation of either or both thebase lens 610 and an inserted power lens. -
FIGS. 7A and 7B provide perspective and top plan views, respectively, of an alternativetoric base assembly 700, in accordance with an embodiment of the present disclosure. Thetoric base assembly 700 includes abase lens 710 and ahaptic system 720. In thetoric base assembly 700 shown inFIGS. 7A and 7B , in addition to havingcutouts 740 to create greater flexibility in certain regions of thehaptic system 720, thehaptic system 720 includes twoextended regions 730 that extend beyond the circumference defined by thehaptic system 720. Theextended regions 730 and thecutouts 740 cause an unequal distribution of compressive forces, resulting in toric deformation of either or both thebase lens 710 and an inserted power lens. - The accommodating IOL may be provided with a base assembly that permits for varying profiles. The varying profiles may be provided by configuring the base assembly such that the power lens is placed farther away from the base lens (i.e., high profile) or closer to the base lens (i.e., low profile).
-
FIGS. 8A-8C depict an embodiment of a high profileIOL base assembly 800.FIG. 8A depicts a perspective view of thebase assembly 800 andFIGS. 8B and 8C depict top plan and cross-sectional views, respectively, of thebase assembly 800. - The
base assembly 800 includes a first open end 800A and a second end 800B that may optionally include abase lens 830. Thehaptic system 810 includes an outer periphery and an inner surface facing a central cavity. The inner surface may comprise a plurality of spaced-apart contact points 862 configured to engage a portion of a peripheral edge of an implanted power lens (not depicted) that may be provided to fit within a central cavity of thebase assembly 800. A plurality oftabs 840 may be provided to extend into acavity 850 and to create a plurality ofrecesses 860 within thecavity 850 to retain a portion of a peripheral edge of a power lens. A plurality of tables 870 extend from a bottom of thebase assembly 800 into thecavity 850 along portions of a periphery of thecavity 850. The tables 870 rise to a level such that a top surface of the tables 870 is in substantially the same plane formed by the bottom surfaces of therecesses 860. The tables 870 in combination with therecesses 860 ensure that an inserted power lens is secured at a desired position within thecavity 850 with respect to thebase lens 830. - The
haptic system 810 has a height h2 between a first edge and a second edge of its outer periphery. The power lens comprises a first side, a second side and a peripheral edge coupling the first and second sides. The power lens may further comprise a closed cavity configured to house a fluid The first side of the power lens is positioned at a predetermined distance h1 from the first edge of thehaptic system 810. This predetermined distance h1 determines the profile of thebase assembly 800. In one exemplary embodiment, the predetermined distance h1 may be in the range of about 0 mm to about 0.75 mm. In accordance with another embodiment, the predetermined distance h1 may be in the range of about 0.01% to about 37% of the height of the haptic h2. As shown inFIG. 8C , the predetermined distance can be measured by reference to a bottom surface of a plurality oftabs 840 that is used to secure a first side of the power lens. Thus, in accordance with this embodiment, the bottom surface of the tabs may be positioned at a distance of about 0 mm to about 0.75 mm from the first edge of thehaptic system 810 or at a distance, from the first edge of thehaptic system 810, of about 0.01% to about 37% of the height h2 of thehaptic system 810. - The
haptic system 810 may be substantially circular with a plurality ofouter grooves 820. Theouter grooves 820 may extend along at least a portion of the height of thehaptic system 810. Theouter grooves 820 may be configured to permit the haptic to be radially compressed, radially expanded, or both. In one embodiment, theouter grooves 820 may be disposed in the outer periphery of thehaptic system 810 opposite the inner surface contact points 862. -
FIGS. 9 and 10 depict embodiments of a low profile base assembly. -
FIG. 9A depicts a perspective view of an accommodatingintraocular lens 900 including abase assembly 900 and apower lens 920 coupled to thebase assembly 910. Compared to thebase assembly 800 ofFIG. 8A , thebase assembly 900 of theaccommodating IOL 900 is configured to position thepower lens 920 deeper within thebase assembly 910, and closer to a base lens of thebase assembly 910.FIG. 9B provides a top plan view of the accommodating IOL andFIG. 9C provides a cross-sectional view of the accommodating IOL including thebase assembly 900 and thepower lens 920. The accommodating IOL includes apower lens 920 that is secured in thebase assembly 900, and held in place, in part, by a plurality oftabs 930 that extend radially inwardly from thebase assembly 900 into a central cavity within thebase assembly 900. The bottom surface of thetabs 930 contact a first side of thepower lens 920, similarly as withFIG. 8C . As can be seen most clearly inFIG. 9C , thepower lens 920 is positioned proximate abase lens 940. In the embodiment shown, thepower lens 920 comprises aflexible membrane 950, and apower lens optic 960. Theflexible membrane 950 and the power lens optic are spaced apart, and a fluid fills the space between the two. Thepower lens optic 960 and thebase lens 940 are proximate one another. - A
haptic system 910 has a height h2 between a first edge and a second edge of its outer periphery. The power lens comprises a first side, a second side and a peripheral edge coupling the first and second sides. The power lens may further comprise a closed cavity configured to house a fluid The first side of the power lens is positioned at a predetermined distance h1 from the first edge of thehaptic system 910. This predetermined distance h1 determines the profile of thebase assembly 900. In one exemplary embodiment, the predetermined distance h1 may be in the range of about 0 mm to about 0.75 mm. In accordance with another embodiment, the predetermined distance h1 may be in the range of about 0.01% to about 37% of the height of the haptic h2. As shown inFIG. 9C , the predetermined distance can be measured by reference to a bottom surface of a plurality oftabs 930 that is used to secure a first side of the power lens. Thus, in accordance with this embodiment, the bottom surface of the tabs may be positioned at a distance of about 0.75 mm to about 1.5 mm from the first edge of thehaptic system 810 or at a distance, from the first edge of thehaptic system 910, of about 38% to about 75% of the height h2 of thehaptic system 910. - The
haptic system 910 may be substantially circular with a plurality ofouter grooves 920. Theouter grooves 920 may extend along at least a portion of the height of thehaptic system 910. Theouter grooves 920 may be configured to permit the haptic to be radially compressed, radially expanded, or both. In one embodiment, theouter grooves 920 may be disposed in the outer periphery of thehaptic system 910 opposite the inner surface contact points 962. - The lower profile of the accommodating IOL amplifies power change by the
accommodating IOL 900, as will be described in greater detail below with respect toFIG. 10 . -
FIGS. 10A-10D depict another embodiment of a lowprofile accommodating IOL 1000, in which a lowprofile base assembly 1010 is configured to place apower lens 1020 deeper within thebase assembly 1010, in close proximity with abase lens 1030, to create a greater range of optical power possible with a particular IOL configuration. The lowprofile accommodating IOL 1000 includes abase assembly 1010, and apower lens 1020 configured to be secured within thebase assembly 1010. Thebase assembly 1010 comprises ahaptic portion 1015 for translating forces applied to the periphery of thehaptic portion 1015 to thepower lens 1020. - As can be seen in cross sectional view of
FIG. 10D , thepower lens 1020 includes aflexible membrane 1050 and apower lens optic 1040, while thebase assembly 1010 includes ahaptic portion 1015 for translating forces applied to the periphery of thehaptic portion 1015 to thepower lens 1020 and abase lens 1030. Thebase lens 1030 and thepower lens optic 1040 are proximate one another, and the lower profile of the accommodating IOL amplifies power change by thepower lens 1020. Change in power by theaccommodating IOL 1000 is largely produced by accommodation of thepower lens 1020. Furthermore, accommodation of thepower lens 1020 is most effectively produced by applying forces to themembrane 1050, rather than to thepower lens optic 1040. As such, power change of theaccommodating IOL 1000 is most efficient when forces applied to the periphery of the haptic 1015 are translated efficiently to themembrane 1050. - The low
profile accommodating IOL 1000 efficiently translates forces from the haptic 1015 to themembrane 1050 in several ways. First, placement of thepower lens 1020 deeper within the haptic 1015 leads to more efficient translation of forces from the haptic 1015 to the power lens 1020 (which comprises the membrane 1050). This is due, at least in part, to the fact that when thepower lens 1020 is positioned higher up within the haptic 1015, a greater proportion of the forces exerted on the periphery of the haptic 1015 are distributed to thebase lens 1030, rather than thepower lens 1020. The portion of the force that is distributed to thebase lens 1030 does not significantly affect accommodation and/or power change, and therefore, is not utilized efficiently to effect power change by theaccommodating IOL 1000. By moving thepower lens 1020 lower within the haptic 1015, a greater proportion of forces are distributed to thepower lens 1020 rather than being lost to thebase lens 1030. Furthermore, placement of thepower lens 1020 proximate thebase lens 1030 allows for thepower lens 1020 to be in closer proximity with ahinge portion 1090, which translates at least a portion of the forces being distributed to thebase lens 1030 to thepower lens 1020. - As discussed above, even if forces are applied to the
power lens 1020, accommodation is maximized when forces are applied to themembrane 1050 rather than thepower lens optic 1040. Acutout 1080 on a lower portion of a periphery of thepower lens 1020 results in forces being translated to themembrane 1050 rather than thepower lens optic 1040. By removing a lower portion of the periphery of the power lens 1020 (cutout 1080), the haptic 1015 engages primarily with anupper portion 1070 of the periphery of thepower lens 1020 and forces are exerted primarily on the membrane 1050 (which is on the upper portion of the power lens 1020) rather than the power lens optic 1040 (which is on the lower portion of the power lens 1020), thereby affecting greater power change in thepower lens 1020. - In the embodiment depicted in
FIGS. 8A-8C , the accommodating intraocular lens may have a higher profile as compared to the embodiments depicted inFIGS. 9 and 10 . In other words, in the high profile embodiments, the power lens is positioned closer to the open end of thehaptic system 810 and farther away from the base lens 830 (FIGS. 8A-8C ) and in the low profile embodiments, thepower lens base lens 940, 1030 (FIGS. 9A-9C andFIGS. 10A-10D ). The position of the power lens is represented inFIGS. 8C and 10D with reference to the distance h1 of the peripheral edge of the power lens from the first edge of the outer periphery of the haptic. - Thus, in accordance with one aspect, the power lens is positioned at a predetermined distance from the first edge of the outer periphery of the haptic, as represented by h1 in
FIGS. 8C and 10D . In one aspect, the predetermined distance h1 may be about 0 mm. about 0.1 mm, about 0.15 mm, about 0.2 mm, about 0.25 mm, about 0.30 mm, about 0.35 mm, about 0.40 mm, about 0.45 mm, about 0.50 mm, about 0.55 mm, about 0.60 mm, about 0.65 mm, about 0.70 mm, about 0.75 mm, about 0.80 mm, about 0.85 mm, about 0.90 mm, about 0.95 mm, about 1 mm, about 1.1 mm, about 1.15 mm, about 1.2 mm, about 1.25 mm, about 1.3 mm, about 1.35 mm, about 1.4 mm, about 1.45 mm, about 1.5 mm, about 1.55 mm, about 1.6 mm, about 1.65 mm, about 1.7 mm, about 1.75 mm, about 1.8 mm, about 1.85 mm, about 1.9 mm, about 1.95 mm, and about 2 mm. In another aspect, the predetermined distance h1 is may be provided within a range that is between and includes any two of the foregoing values. In a further aspect, the predetermined distance h1 for a high profile accommodating IOL may be in the range of about 0 mm to about 0.75 mm. In yet a further aspect, the predetermined distance h1 for a low profile accommodating IOL may be in the range of greater than 0.75 mm to about 1 mm. - The predetermined distance h1 may also be provided as a percentage of the total height h2 of the outer periphery of the
haptic system haptic system haptic system haptic system -
FIG. 11A depicts a perspective view of an accommodating IOL 1100 including abase assembly 1110 and apower lens 1120, in accordance with an embodiment of the present disclosure.FIG. 11B provides an exploded view of the accommodating IOL 1100,FIG. 11C provides a top plan view of the accommodating IOL 1100, andFIG. 11D provides a cross-sectional view of the accommodating IOL 1100. Thebase assembly 1110 includes ahaptic system 1130. As most clearly seen inFIG. 11C , thehaptic system 1130 includes a plurality of recesses orcutouts 1140 defined within an inner periphery of thehaptic system 1130 for receiving one ormore fins 1150 extending from a peripheral edge of thepower lens 1120. The plurality of recesses orcutouts 1140 may be defined by a raised portion ortab 1160 and an entry passage on at least one side of the raised portion. Thepower lens 1120 is lowered into thebase assembly 1110 such that each of thefins 1150 enter in through one of the plurality ofcutouts 1140. Thepower lens 1120 is then rotated, such that eachfin 1150 is no longer positioned within one of thecutouts 1140, but rather, is positioned below one of a plurality oftabs 1160. Once each fin 1150 (or at least one of the fins 1150) is positioned below atab 1160, thepower lens 1120 becomes secured to thebase assembly 1110. In certain embodiments, manipulation holes may be created on thepower lens 1120 to allow a user to insert a tool into the one or more manipulation holes to assist in rotating thepower lens 1120. -
FIGS. 12A-12F provide various views of anaccommodating IOL 1200, according to an embodiment of the present disclosure. In this embodiment, the accommodatingIOL 1200 comprises abase assembly 1210 and apower lens 1220. Thebase assembly 1210 includesabase lens 1290. Thepower lens 1220 includes aflexible membrane 1230 and an optic 1235 andflanges 1240 that extend outwardly from a peripheral edge of thepower lens 1220. Theflanges 1240 can be inserted into achannel 1250 that is formed in the inner periphery of thebase assembly 1240 or haptic by a plurality ofupper tabs 1260 andlower tabs 1270. The positioning of theflanges 1240 towards the anterior portion of thepower lens 1220 may be advantageous in that theflanges 1240 and thetabs 1260 securing theflanges 1240 are positioned such that they do not interfere with the visual elements of the accommodating IOL, i.e., theflexible membrane 1230, the optic 1235, and thebase lens 1290. As such, visual artifacts or light distortions caused by the flanges and thetabs flanges 1240 do not extend out of thepower lens 1220 atregions 1280 to allow for easier insertion of thepower lens 1220 into thebase assembly 1210. -
FIGS. 13A-13C depict an embodiment abase assembly 1300 with extended tabs for an accommodating IOL. Thebase assembly 1300 includes ahaptic system 1310 and acavity 1320 for receiving a power lens.Extended tabs 1330 extend over a portion of the circumference of thehaptic system 1310 and into the cavity. Theextended tabs 1330 are used to secure a power lens within thebase assembly 1310. In certain embodiments, eachtab 1330 may be measured by an angular coverage, indicative of the portion of the circumference encompassed by eachtab 1330. In certain embodiments, eachtab 1330 may encompass between 30 degrees and 180 degrees. Eachtab 1330 may also include a width measurement, indicative of how far in towards the center of the base assembly thetab 1330 extends. An outer edge of thehaptic system 1310 and applicable haptic systems described in this disclosure can be approximately 1 mm thick. -
FIGS. 14A-D depict various views of an astigmatism-free base ring 1400, in accordance with an embodiment of the present disclosure. The astigmatism-free base ring 1400 is a fluid-filled base ring configured to receive a power lens in a manner as depicted with reference toFIGS. 1C and 3C . The astigmatism-free base ring 1400 includes ahaptic system 1410 and may be provided as a ring shaped to enclose aregion 1420. A power lens may be inserted into the reg 10n 1420 to form an accommodating IOL. The astigmatism-free base ring 1400 includesupper flanges 1430 and alower surface 1435 to secure the power lens between theupper flanges 1430 and thelower surface 1435. -
FIG. 14C provides a cross-sectional view of the astigmaticfree base ring 1400. The astigmatism-free base ring 1400 may include anouter reservoir 1440 and aninner reservoir 1450. Theouter reservoir 1440 and theinner reservoir 1450 may contain a fluid, and may be in fluid communication with one another. In one embodiment, theouter reservoir 1440 and theinner reservoir 1450 may be provided in fluid communication with one another through achannel 1460 that is narrower than at least one of theouter reservoir 1440 and theinner reservoir 1450. The use of the tworeservoirs channel 1460 more evenly distributes a radially-compressive force onto the inner surface of thebase ring 1400 that is located between theupper flange 1420 and thelower surface 1435 when a radially compressive force applied to the periphery of thehaptic system 1410. As such, a more even, non-toric deformation is created in the accommodating IOL. -
FIG. 14D provides a cross-sectional view of an alternative embodiment of the astigmatism-free base ring 1400. In certain embodiments, a mesh braid, such as that shown inFIG. 14E , may be incorporated into theinner reservoir 1450. In certain embodiments, the mesh braid may comprise a Nitinol braid. The mesh braid (FIG. 14E ) may allow for fluid to flow between the inner andouter reservoirs free base ring 1400. Thus, in one embodiment, thebase ring 1400 described above may further comprise a porous support structure or a mesh braid, such as the one depicted inFIG. 14E , which may be disposed along a portion of or along an entirety of theinner reservoir 1450. -
FIG. 15A depicts a perspective view of anaccommodating IOL 1500 having a base assembly and power lens that is attached or attachable to one another by bonding or insert molding.FIG. 15B provides a top plan view of theaccommodating IOL 1500.FIG. 15C depicts a cross-sectional view of theaccommodating IOL 1500.FIG. 15D depicts a bottom perspective view of theaccommodating IOL 1500. Theaccommodating IOL 1500 includes ahaptic base assembly 1510 attached to apower lens 1520 during manufacture. The attachment may be effectuated by one or both of bonding or insert molding, in which one of thebase assembly 1510 and thepower lens 1520 is molded and then the other of thebase assembly 1510 and thepower lens 1520 is molded directly onto the first molded part (i.e., thebase assembly 1510 or the power lens 1520). The portion of thepower lens 1520 that is attached to thebase assembly 1510 may be one or both of a portion of the circumferential peripheral edge 1522 or a posterior edge 1524 of thepower lens 1520. The entireaccommodating IOL 1500 can then be inserted into a patient. In order to reduce the bulk of the bonded base and power lens, theaccommodating IOL 1500 can include just a single optic, such that power correction comes only from thepower lens 1520. Thus, in one embodiment, thebase assembly 1510 itself does not comprise an optic that provides refractive correction and theIOL 1500 only comprises thepower lens 1520 to provide refractive correction. -
FIGS. 16A-F depict various views a nogap accommodating IOL 1600 including agapless base assembly 1610 and apower lens 1620. Thegapless base assembly 1610 includes abase lens 1630 and ahaptic system 1640. Thebase lens 1630 and the haptic system 1104 are secured together so no gaps are formed leading into thepower lens 1620. This limits the ability of cells to flow into acavity 1670 between thebase lens 1630 and thepower lens 1620 when apower lens 1620 is inserted into thegapless base assembly 1610. In various embodiments, a similar effect may be had by applying a Parylene coating a base assembly having gaps to prevent cell migration into and out of the cavity between the power lens and the base lens. - In various embodiments, the base assemblies described in this paper can provide a portion of power correction. As a result, a base assembly can be installed and an appropriate power lens to install can be selected to allow for correction within ¼ of a diopter. Further, in various embodiments, an optic of the base assemblies can include a UV absorber or UV absorbent coating to absorb UV entering the eye of the patient. In various embodiments Purkinje images can be used to adjust a power lens or a base assembly to ensure that they are properly installed during the installation of the accommodating IOL.
- In various embodiments, through the use of a power lens and a base assembly, such as the base assemblies described in this disclosure, the two-part accommodating IOLs disclosed herein allow for greater efficiency in cataloguing products. For example, 4 base assemblies and 9 power lenses are needed to cover a range of 12 to 27.5 diopters at half diopter steps. Using single lenses requires 32 different lenses. As only 4 base assemblies and 9 power lenses are needed, only 13 stock keeping units (hereinafter referred to as “SKUs”) are needed to store and organize the power lenses and base assemblies as opposed to 32 different SKUs. This reduces chances of misplacement and leads to easier organization. This increase in efficiency is even greater with respect to toric lenses. For example, assuming 4 different toric powers, for 32 single lens types, 128 SKUs are need to organize the lenses. However, with a two-part accommodating IOL, assuming 4 different toric powers of the base assemblies, only 16 base assemblies and 9 power lenses are needed, for a total of 25 SKUs, which is dramatically less than the 128 SKUs needed for single toric lenses.
- In various embodiments, the tabs and the flanges of the base assemblies discussed in this paper can be colored differently than a power lens to allow a surgeon to see when a power lens has been correctly inserted into a base assembly. In various embodiments, a power lens or an edge of a power lens can be colored to further aid in insertion of the power lens into a base assembly. In various embodiments a base lens or a haptic system of a base assembly can be colored. Coloration can be achieved by adding roughness or a coating to outer surfaces of any of the previously described components.
- In various embodiments, Purkinje images may be utilized to assist in adjustment and placement of a power lens into a base assembly. Images can be used to adjust the power lens and base lens after implantation to assure the best fit. This approach gives immediate and simple feedback for the surgeon through the eye piece of a scope. For example, a surgeon can receive an indication that a power lens is correctly placed into a base lens if the surgeon can see a perfect circle when looking through the scope. If the circle is deformed or misshaped at all, the surgeon will know that they have to continue adjusting the power lens.
Claims (21)
1. (canceled)
2. An intraocular lens device comprising:
a first component comprising a first open end, a second end comprising a first lens, a haptic surrounding a cavity, and a plurality of anterior walls extending inward from the haptic; and
a second component configured to be positioned within the cavity of the first component, the second component comprising a second lens having a peripheral edge and a plurality of fins extending radially outward from the peripheral edge;
wherein the plurality of fins are configured to be disposed posterior to the plurality of anterior walls to secure the second component within the cavity of the first component.
3. The intraocular lens device of claim 2 , wherein the second component is configured to be disposed in the cavity of the first component after insertion of the first component into an eye of a patient.
4. The intraocular lens device of claim 2 , wherein the plurality of fins are circumferentially distributed about the peripheral edge of the second component.
5. The intraocular lens device of claim 2 , wherein each of the plurality of fins is equidistantly spaced from adjacent fins of the plurality of fins in a circumferential direction.
6. The intraocular lens device of claim 2 , wherein the plurality of fins comprises three fins.
7. The intraocular lens device of claim 2 , wherein at least one of the plurality of fins comprises a thickness that is greater in an anterior-posterior direction compared to a thickness of the at least one of the plurality of fins in a circumferential direction.
8. The intraocular lens device of claim 2 , wherein at least one of the plurality of fins comprises a thickness that is greater in a circumferential direction compared to a thickness of the at least one of the plurality of fins in an anterior-posterior direction.
9. The intraocular lens device of claim 2 , wherein the haptic comprises a plurality of notches disposed in an outer periphery.
10. The intraocular lens device of claim 9 , wherein each of the plurality of notches is equidistantly spaced from adjacent notches of the plurality of notches in a circumferential direction.
11. The intraocular lens device of claim 9 , wherein the plurality of notches comprises three notches.
12. The intraocular lens device of claim 2 , wherein the second component is configured to be disposed anterior to the first lens.
13. The intraocular lens device of claim 2 , wherein the second component comprises a biconvex optic.
14. The intraocular lens device of claim 13 , wherein the second component further comprises a membrane that together with the biconvex optic bounds a space configured to receive a fluid.
15. The intraocular lens device of claim 2 , wherein the plurality of anterior walls comprise a first color to aid a surgeon in assembling the intraocular lens device in an eye, wherein the first color is different than a second color of the second component.
16. The intraocular lens device of claim 2 , wherein the haptic comprises a plurality of cutouts that are open in an anterior direction.
17. An intraocular lens device comprising:
a lens housing comprising a first open end, a second end comprising a first focusing element, a haptic surrounding a space, and a plurality of anterior walls, each of the plurality of anterior walls spanning between 30 and 180 degrees of a circumference of the haptic; and
a second focusing element configured to be positioned within the space, the second focusing element comprising a peripheral edge and a plurality of flanges extending radially outward from the peripheral edge;
wherein each of the plurality of flanges is configured to be disposed posterior to one of the plurality of anterior walls to secure the second focusing element within the space of the lens housing.
18. The intraocular lens device of claim 17 , wherein the second focusing element is configured to be positioned within the space and anterior to the first focusing element after placement of the lens housing within an eye.
19. The intraocular lens device of claim 17 , wherein the plurality of anterior walls comprise a first color to aid a surgeon in assembling the intraocular lens device in an eye, wherein the first color is different than a second color of the second focusing element.
20. An intraocular lens device comprising:
a fluid-filled posterior lens assembly comprising a first open end, a second end comprising a posterior lens, a haptic comprising a reservoir surrounding a space, and a channel disposed between an upper surface and a lower surface, wherein forces transmitted to the haptic are transmitted by the fluid in the reservoir to the posterior lens; and
an anterior lens configured to be positioned within the space after insertion of the fluid-filled posterior lens assembly within an eye, the anterior lens comprising biconvex lens element and a peripheral edge extending radially outward from and circumferentially distributed about the biconvex lens element;
wherein the peripheral edge is configured to be disposed in the channel to secure the anterior lens within the space of the fluid-filled posterior lens assembly.
21. The intraocular lens device of claim 20 , wherein the fluid-filled posterior lens assembly comprises an anterior wall, the anterior wall comprising the upper surface and a first color that is different than a second color of the anterior lens to aid a surgeon in assembling the intraocular lens device in the eye.
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Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102883682A (en) | 2010-04-27 | 2013-01-16 | 雷恩斯根公司 | Accommodating intraocular lens device |
US9220590B2 (en) | 2010-06-10 | 2015-12-29 | Z Lens, Llc | Accommodative intraocular lens and method of improving accommodation |
US9364318B2 (en) | 2012-05-10 | 2016-06-14 | Z Lens, Llc | Accommodative-disaccommodative intraocular lens |
EP3062741B1 (en) | 2013-11-01 | 2023-04-26 | Lensgen, Inc. | Accomodating intraocular lens device |
EP3977962A1 (en) | 2013-11-01 | 2022-04-06 | Lensgen, Inc. | Two-part accomodating intraocular lens device |
US9668916B2 (en) | 2013-11-04 | 2017-06-06 | Vance M. Thompson | Conjunctival cover and methods therefor |
US10285805B2 (en) | 2014-03-28 | 2019-05-14 | Forsight Labs, Llc | Accommodating intraocular lens |
US10004596B2 (en) | 2014-07-31 | 2018-06-26 | Lensgen, Inc. | Accommodating intraocular lens device |
EP3197462A4 (en) | 2014-09-23 | 2018-05-30 | Lensgen, Inc | Polymeric material for accommodating intraocular lenses |
US9869883B2 (en) | 2015-03-11 | 2018-01-16 | Vance M. Thompson | Tear shaping for refractive correction |
EP3383320A4 (en) | 2015-12-01 | 2019-08-21 | Lensgen, Inc | Accommodating intraocular lens device |
US10526353B2 (en) | 2016-05-27 | 2020-01-07 | Lensgen, Inc. | Lens oil having a narrow molecular weight distribution for intraocular lens devices |
JP7074960B2 (en) | 2016-08-24 | 2022-05-25 | カール ツァイス メディテック アーゲー | Dual Mode Adjustable-Non-Adjustable Intraocular Lens |
US10353220B2 (en) | 2016-10-17 | 2019-07-16 | Vance M. Thompson | Tear shaping for refractive correction |
US11523898B2 (en) | 2016-10-28 | 2022-12-13 | Forsight Vision6, Inc. | Accommodating intraocular lens and methods of implantation |
BR112019023625A2 (en) * | 2017-05-09 | 2020-08-18 | Khalid Mentak | accommodation lens without glasses (sfal) |
US11382736B2 (en) * | 2017-06-27 | 2022-07-12 | Alcon Inc. | Injector, intraocular lens system, and related methods |
US11707354B2 (en) | 2017-09-11 | 2023-07-25 | Amo Groningen B.V. | Methods and apparatuses to increase intraocular lenses positional stability |
CN117323062A (en) * | 2017-11-01 | 2024-01-02 | 爱尔康公司 | Stabilization of intraocular lenses and peripheral portions |
EP3494885A1 (en) * | 2017-12-07 | 2019-06-12 | Koninklijke Philips N.V. | Apparatus for presentation of dark field x-ray image information |
WO2019123391A1 (en) * | 2017-12-20 | 2019-06-27 | Novartis Ag | Fluid-filled haptic for an intraocular lens |
US10678067B2 (en) | 2018-04-06 | 2020-06-09 | Vance M. Thompson | Tear shaping for refractive correction |
WO2019236908A1 (en) * | 2018-06-07 | 2019-12-12 | Lensgen, Inc. | Intraocular lens devices and related methods |
US20200085564A1 (en) | 2018-09-18 | 2020-03-19 | Vance M. Thompson | Structures and methods for tear shaping for refractive correction |
WO2020100160A1 (en) * | 2018-11-12 | 2020-05-22 | Abhijeet Khake | Intraocular lens assembly |
BR112021019254A2 (en) | 2019-03-25 | 2021-11-30 | Akkolens Int B V | Combination intraocular lenses for restoration of refraction and accommodation and related methods |
CN114007545A (en) | 2019-05-15 | 2022-02-01 | 爱克透镜国际公司 | Accommodating intraocular lens in combination with mechanical drive |
WO2021034187A1 (en) | 2019-08-19 | 2021-02-25 | Akkolens International B.V. | Accommodative intraocular lens combination with independent fixed and variable power lens sections |
AU2020398888A1 (en) * | 2019-12-11 | 2022-06-16 | Lensgen, Inc. | Fluid lens component for intraocular lens and methods of preparing the same |
DE102019134386A1 (en) | 2019-12-13 | 2021-06-17 | Carl Zeiss Meditec Ag | Intraocular lens |
NL2027301B1 (en) | 2020-01-13 | 2021-10-26 | Akkolens Int B V | Mechanical means for accommodative intraocular lens |
EP4135622A1 (en) * | 2020-04-16 | 2023-02-22 | Alcon Inc. | Multi-part iol with stable iol base design to support a second optic |
NL2028038B1 (en) | 2020-05-11 | 2022-07-04 | Akkolens Int B V | Method to connect and distance hydrophilic intraocular lens elements |
WO2022082170A1 (en) * | 2020-10-12 | 2022-04-21 | Omega Ophthalmics Llc | Prosthetic capsular devices, systems, and methods |
CA3235370A1 (en) * | 2021-10-18 | 2023-04-27 | Anew Iol Technologies, Inc. | Three-dimensional intraocular lens scaffold and add-in lens combination and methods of implantation |
IL290086B2 (en) * | 2022-01-24 | 2023-04-01 | Eyemed Tech Ltd | Intraocular lens holding devices |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4585457A (en) * | 1985-05-16 | 1986-04-29 | Kalb Irvin M | Inflatable intraocular lens |
US5306297A (en) * | 1992-07-06 | 1994-04-26 | Kabi Pharmacia Ophthalmics, Inc. | Intraocular lens haptic with enlarged anchoring head |
US20030204256A1 (en) * | 2002-04-29 | 2003-10-30 | Qun Peng | Accommodative intraocular lens |
US20050085907A1 (en) * | 2000-02-16 | 2005-04-21 | Humanoptics Ag | Intraocular implant and an artificial lens device |
Family Cites Families (423)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4032502A (en) | 1975-10-10 | 1977-06-28 | Dow Corning Corporation | Organosiloxane compositions for liquid injection |
US4073014A (en) | 1976-05-28 | 1978-02-14 | Stanley Poler | Intra-ocular lens |
US4373218A (en) | 1980-11-17 | 1983-02-15 | Schachar Ronald A | Variable power intraocular lens and method of implanting into the posterior chamber |
US4512040A (en) | 1982-06-09 | 1985-04-23 | Mcclure Hubert L | Bifocal intraocular lens |
US4720286A (en) | 1984-07-20 | 1988-01-19 | Bailey Kelvin E | Multifocus intraocular lens |
US4676791A (en) | 1985-08-01 | 1987-06-30 | Surgidev Corporation | Intraocular lens and method for making same |
US4731078A (en) | 1985-08-21 | 1988-03-15 | Kingston Technologies Limited Partnership | Intraocular lens |
US5059668A (en) | 1986-01-20 | 1991-10-22 | Shin-Etsu Chemical Co., Ltd. | Fluorosilicone rubber composition |
US5236970A (en) | 1987-02-05 | 1993-08-17 | Allergan, Inc. | Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses |
US4842601A (en) | 1987-05-18 | 1989-06-27 | Smith S Gregory | Accommodating intraocular lens and method of implanting and using same |
US5074876A (en) | 1987-12-04 | 1991-12-24 | Kelman Charles D | Two piece intraocular lens |
US4888012A (en) | 1988-01-14 | 1989-12-19 | Gerald Horn | Intraocular lens assemblies |
DE68920167T2 (en) | 1988-02-12 | 1995-06-29 | Menicon Co Ltd | Method of making an intraocular lens balloon. |
US4822360A (en) | 1988-03-16 | 1989-04-18 | University Of Utah | Inflatable, intraocular lens and method of implanting the lens in the capsule of an eye |
US4932966A (en) | 1988-08-15 | 1990-06-12 | Storz Instrument Company | Accommodating intraocular lens |
US4882368A (en) | 1988-09-26 | 1989-11-21 | Dow Corning Corporation | Low compression set fluorosilicone rubber |
US4892543A (en) | 1989-02-02 | 1990-01-09 | Turley Dana F | Intraocular lens providing accomodation |
US5227447A (en) | 1989-12-07 | 1993-07-13 | Shin-Etsu Chemical Co., Ltd. | Preparation of high molecular weight organopolysiloxane |
US5152788A (en) | 1989-12-27 | 1992-10-06 | Minnesota Mining And Manufacturing Company | Multifocal diffractive ophthalmic lens and method of manufacture |
JPH03202102A (en) | 1989-12-28 | 1991-09-03 | Toray Dow Corning Silicone Co Ltd | Method for reducing amount of siloxane oligomer in organopolysiloxane molded product |
US6197059B1 (en) | 1990-04-27 | 2001-03-06 | Medevec Licensing, B.V. | Accomodating intraocular lens |
US5217491A (en) | 1990-12-27 | 1993-06-08 | American Cyanamid Company | Composite intraocular lens |
CN1064611A (en) | 1991-03-11 | 1992-09-23 | 罗伯特·G·威利 | Intraocular lens with variable optical strength of astigmatism correction ability |
WO1992017132A1 (en) | 1991-03-25 | 1992-10-15 | Albert Daxer | Artificial eye-lens |
FR2681524B1 (en) | 1991-09-25 | 1997-04-04 | Mnao | CRYSTALLINE IMPLANT. |
US5171773A (en) | 1991-11-13 | 1992-12-15 | Dow Corning Corporation | High strength fluorosilicone rubber |
US5275623A (en) | 1991-11-18 | 1994-01-04 | Faezeh Sarfarazi | Elliptical accommodative intraocular lens for small incision surgery |
US20040015236A1 (en) | 1991-11-18 | 2004-01-22 | Sarfarazi Faezeh M. | Sarfarazi elliptical accommodative intraocular lens for small incision surgery |
US5278258A (en) | 1992-05-18 | 1994-01-11 | Allergan, Inc. | Cross-linked silicone polymers, fast curing silicone precursor compositions, and injectable intraocular lenses |
US5264522A (en) | 1992-09-10 | 1993-11-23 | Shin-Etsu Chemical Co., Ltd. | Heat-curable fluorosilicone rubber composition and cured product thereof |
US5312860A (en) | 1992-09-10 | 1994-05-17 | Shin-Etsu Chemical Co., Ltd. | Heat-curable silicone rubber composition and cured product thereof |
US5443506A (en) | 1992-11-18 | 1995-08-22 | Garabet; Antoine L. | Lens with variable optical properties |
US5336487A (en) | 1993-03-05 | 1994-08-09 | Refojo Miguel F | Method of treating eye disorders with silicon/fluorosilicone copolymer oil |
US5447987A (en) | 1993-12-24 | 1995-09-05 | Shin-Etsu Chemical Co., Ltd. | Organopolysiloxane compositions |
BR9507054A (en) | 1994-01-31 | 1997-09-16 | Bausch & Lomb | Method for producing an optically transparent lens |
US5489302A (en) | 1994-05-24 | 1996-02-06 | Skottun; Bernt C. | Accommodating intraocular lens |
EP0767809B1 (en) | 1994-06-30 | 2004-01-21 | Minnesota Mining And Manufacturing Company | Cure-indicating molding and coating composition |
US5607472A (en) | 1995-05-09 | 1997-03-04 | Emory University | Intraocular lens for restoring accommodation and allows adjustment of optical power |
US5774274A (en) | 1995-05-12 | 1998-06-30 | Schachar; Ronald A. | Variable focus lens by small changes of the equatorial lens diameter |
JPH09150002A (en) | 1995-11-29 | 1997-06-10 | Shin Etsu Chem Co Ltd | Refining method for silicone oil |
US5800533A (en) * | 1996-03-18 | 1998-09-01 | Harry C. Eggleston | Adjustable intraocular lens implant with magnetic adjustment facilities |
US5665794A (en) | 1996-05-20 | 1997-09-09 | Dow Corning Corporation | Method for controlling cure initiation and curing times of platinum group metal curing fluorosilicone compositions |
DE19654488A1 (en) | 1996-12-27 | 1998-07-02 | Sueddeutsche Kalkstickstoff | Process for the fractionation of viscous silicones |
US5854310A (en) | 1997-07-21 | 1998-12-29 | Dow Corning Corporation | Curable fluorosilicone composition having improved lubricity |
FR2778093B1 (en) | 1998-05-04 | 2000-06-16 | Khalil Hanna | INTRAOCULAR IMPLANT |
US6361561B1 (en) | 1998-10-13 | 2002-03-26 | Pharmacia & Upjohn Ab | Injectable intraocular lens |
FR2784575B1 (en) | 1998-10-15 | 2000-12-22 | Megaoptic Gmbh | ACCOMMODATIVE INTRAOCULAR IMPLANT |
US6197057B1 (en) | 1998-10-27 | 2001-03-06 | Gholam A. Peyman | Lens conversion system for teledioptic or difractive configurations |
US6117171A (en) | 1998-12-23 | 2000-09-12 | Skottun; Bernt Christian | Encapsulated accommodating intraocular lens |
US7662179B2 (en) | 1999-04-09 | 2010-02-16 | Sarfarazi Faezeh M | Haptics for accommodative intraocular lens system |
US8556967B2 (en) | 1999-04-09 | 2013-10-15 | Faezeh Mona Sarfarazi | Interior bag for a capsular bag and injector |
US6200581B1 (en) | 1999-04-28 | 2001-03-13 | Dow Corning Corporation | Elastomeric silicone terpolymer |
US20060238702A1 (en) | 1999-04-30 | 2006-10-26 | Advanced Medical Optics, Inc. | Ophthalmic lens combinations |
US20030060881A1 (en) | 1999-04-30 | 2003-03-27 | Advanced Medical Optics, Inc. | Intraocular lens combinations |
US6200342B1 (en) | 1999-05-11 | 2001-03-13 | Marie-Jose B. Tassignon | Intraocular lens with accommodative properties |
US6201091B1 (en) | 1999-08-20 | 2001-03-13 | Dow Corning Corporation | Organofunctional cocyclic siloxanes and polymerization thereof |
US6767363B1 (en) | 1999-11-05 | 2004-07-27 | Bausch & Lomb Surgical, Inc. | Accommodating positive and negative intraocular lens system |
FR2804860B1 (en) | 2000-02-16 | 2002-04-12 | Humanoptics Ag | ACCOMODATIVE CRYSTALLINE IMPLANT |
US6797004B1 (en) | 2000-03-02 | 2004-09-28 | Advanced Medical Optics, Inc. | Holders for intraocular lenses |
US6551354B1 (en) | 2000-03-09 | 2003-04-22 | Advanced Medical Optics, Inc. | Accommodating intraocular lens |
US6613343B2 (en) | 2000-04-12 | 2003-09-02 | Pharmacia Groningen Bv | Injectable intraocular accommodating lens |
US20050251254A1 (en) | 2000-06-02 | 2005-11-10 | Brady Daniel G | Method of implanting accommodating intraocular lenses |
US6730123B1 (en) | 2000-06-22 | 2004-05-04 | Proteus Vision, Llc | Adjustable intraocular lens |
WO2002005015A2 (en) | 2000-07-11 | 2002-01-17 | The Johns Hopkins University School Of Medicine | Device for inserting an injectable bag intraocular lens within a human eye |
WO2002009619A2 (en) | 2000-07-28 | 2002-02-07 | Kiyoshi Okada | Intraocular lenses with reduced complications |
US20030078657A1 (en) | 2001-01-25 | 2003-04-24 | Gholam-Reza Zadno-Azizi | Materials for use in accommodating intraocular lens system |
US7780729B2 (en) | 2004-04-16 | 2010-08-24 | Visiogen, Inc. | Intraocular lens |
US7087080B2 (en) | 2001-01-25 | 2006-08-08 | Visiogen, Inc. | Materials for use in intraocular lens system |
US8062361B2 (en) | 2001-01-25 | 2011-11-22 | Visiogen, Inc. | Accommodating intraocular lens system with aberration-enhanced performance |
US20040148023A1 (en) | 2001-02-15 | 2004-07-29 | Shu Stephen K. | High gain wide range accommodating intraocular lens for implant into the capsular bag |
US20020120329A1 (en) | 2001-02-28 | 2002-08-29 | Allergan Sales, Inc. | Moveable intraocular lenses and combinations of intraocular lenses |
US20030105522A1 (en) | 2001-06-11 | 2003-06-05 | Glazier Alan N. | Multi-focal intraocular lens |
US6855164B2 (en) | 2001-06-11 | 2005-02-15 | Vision Solutions Technologies, Llc | Multi-focal intraocular lens, and methods for making and using same |
US7229475B2 (en) | 2001-06-11 | 2007-06-12 | Vision Solutions Technologies, Inc. | Multi-focal intraocular lens, and methods for making and using same |
IL145015A0 (en) | 2001-08-21 | 2002-06-30 | Nun Yehoshua Ben | Accommodating lens |
US20030060878A1 (en) | 2001-08-31 | 2003-03-27 | Shadduck John H. | Intraocular lens system and method for power adjustment |
US7097660B2 (en) | 2001-12-10 | 2006-08-29 | Valdemar Portney | Accommodating intraocular lens |
JP3985133B2 (en) | 2001-12-21 | 2007-10-03 | 信越化学工業株式会社 | Thixo fluorine-containing curable composition and encapsulated material using the same |
US20050021139A1 (en) | 2003-02-03 | 2005-01-27 | Shadduck John H. | Ophthalmic devices, methods of use and methods of fabrication |
US20070100445A1 (en) | 2003-02-03 | 2007-05-03 | Shadduck John H | Intraocular lenses and business methods |
US7261737B2 (en) | 2002-12-12 | 2007-08-28 | Powervision, Inc. | Accommodating intraocular lens system and method |
US8048155B2 (en) | 2002-02-02 | 2011-11-01 | Powervision, Inc. | Intraocular implant devices |
US6860601B2 (en) | 2002-02-06 | 2005-03-01 | John H. Shadduck | Adaptive optic lens system and method of use |
US20030181749A1 (en) | 2002-03-21 | 2003-09-25 | Kunzler Jay F. | Supercritical fluid extraction of vitreoretinal silicone tamponades |
US7416562B2 (en) | 2002-07-29 | 2008-08-26 | Yosef Gross | Tensioning intraocular lens assembly |
AU2002950469A0 (en) | 2002-07-30 | 2002-09-12 | Commonwealth Scientific And Industrial Research Organisation | Improved biomedical compositions |
US6966649B2 (en) | 2002-08-12 | 2005-11-22 | John H Shadduck | Adaptive optic lens system and method of use |
KR101476067B1 (en) | 2002-09-06 | 2014-12-23 | 인설트 테라페틱스, 인코퍼레이티드 | Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto |
FR2844703B1 (en) | 2002-09-25 | 2005-07-08 | Alain Nicolas Gilg | INTRAOCULAR DEVICE FOR RESTORING THE ACCOMMODATION OF THE EYE WITH PRESBYOPIA |
JP4473217B2 (en) | 2002-10-25 | 2010-06-02 | クエスト ヴィジョン テクノロジー, アイエヌシー. | Implantable artificial lens |
US20040082993A1 (en) | 2002-10-25 | 2004-04-29 | Randall Woods | Capsular intraocular lens implant having a refractive liquid therein |
US7125422B2 (en) | 2002-10-25 | 2006-10-24 | Quest Vision Technology, Inc. | Accommodating intraocular lens implant |
WO2004046768A2 (en) | 2002-11-20 | 2004-06-03 | Powervision | Lens system and method for power adjustment |
US6991651B2 (en) | 2002-11-27 | 2006-01-31 | Valdemar Portney | Adjustable intraocular lens system and intraocular lenses therefor |
US20040111152A1 (en) | 2002-12-10 | 2004-06-10 | Kelman Charles David | Accommodating multifocal intraocular lens |
US7247168B2 (en) | 2002-12-12 | 2007-07-24 | Powervision, Inc. | Accommodating intraocular lens system and method |
US8328869B2 (en) | 2002-12-12 | 2012-12-11 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
US7217288B2 (en) | 2002-12-12 | 2007-05-15 | Powervision, Inc. | Accommodating intraocular lens having peripherally actuated deflectable surface and method |
US8361145B2 (en) | 2002-12-12 | 2013-01-29 | Powervision, Inc. | Accommodating intraocular lens system having circumferential haptic support and method |
US7637947B2 (en) * | 2002-12-12 | 2009-12-29 | Powervision, Inc. | Accommodating intraocular lens system having spherical aberration compensation and method |
US7438723B2 (en) | 2002-12-12 | 2008-10-21 | Powervision, Inc. | Lens system and method for power adjustment using externally actuated micropumps |
WO2004054471A2 (en) | 2002-12-12 | 2004-07-01 | Powervision | Accommodating intraocular lens system and method |
US10835373B2 (en) | 2002-12-12 | 2020-11-17 | Alcon Inc. | Accommodating intraocular lenses and methods of use |
US6616691B1 (en) | 2003-01-10 | 2003-09-09 | Alcon, Inc. | Accommodative intraocular lens |
US7238201B2 (en) | 2003-02-13 | 2007-07-03 | Visiogen, Inc. | Accommodating intraocular lens system with enhanced range of motion |
CA2517576A1 (en) | 2003-03-06 | 2004-09-23 | John H. Shadduck | Adaptive optic lens and method of making |
US7223288B2 (en) | 2003-05-21 | 2007-05-29 | Alcon, Inc. | Accommodative intraocular lens |
US20040249455A1 (en) | 2003-06-09 | 2004-12-09 | Tran Son Trung | Accommodative intraocular lens system |
GB0319408D0 (en) | 2003-08-19 | 2003-09-17 | Chawdhary Satish | Intraocular device |
DE10346024B4 (en) | 2003-08-26 | 2019-01-17 | Carl Zeiss Meditec Ag | Ciliary muscle-operated, accommodative lens implant |
DE20316792U1 (en) | 2003-08-26 | 2005-01-05 | Schedler, Markus | Ciliary muscle-operated, accommodative lens implant |
US20050107873A1 (en) | 2003-11-18 | 2005-05-19 | Medennium, Inc. | Accommodative intraocular lens and method of implantation |
US20050137703A1 (en) | 2003-12-05 | 2005-06-23 | Vanderbilt University | Accommodative intraocular lens |
US20050131535A1 (en) | 2003-12-15 | 2005-06-16 | Randall Woods | Intraocular lens implant having posterior bendable optic |
NL1025622C2 (en) | 2004-03-03 | 2005-09-07 | Accolens Internat B V | Two optical elements with variable optical power together forming a lens for use as an intraocular lens. |
US7150760B2 (en) | 2004-03-22 | 2006-12-19 | Alcon, Inc. | Accommodative intraocular lens system |
US8018658B2 (en) | 2004-03-31 | 2011-09-13 | The Regents Of The Univeristy Of California | Fluidic adaptive lens systems and methods |
US20110118834A1 (en) | 2004-03-31 | 2011-05-19 | Yuhwa Lo | Fluidic intraocular lens systems and methods |
US7453646B2 (en) | 2004-03-31 | 2008-11-18 | The Regents Of The University Of California | Fluidic adaptive lens systems and methods |
US7675686B2 (en) | 2004-03-31 | 2010-03-09 | The Regents Of The University Of California | Fluidic adaptive lens |
IL161706A0 (en) | 2004-04-29 | 2004-09-27 | Nulens Ltd | Intraocular lens fixation device |
US9713527B2 (en) | 2004-04-30 | 2017-07-25 | Rxsight, Inc. | Multilens intraocular lens system with injectable accommodation material |
US9005282B2 (en) | 2004-04-30 | 2015-04-14 | Calhoun Vision, Inc. | Intraocular lens system with injectable accommodation material |
US7063723B2 (en) | 2004-07-23 | 2006-06-20 | Sun Ran | Intraocular lens with an accommodating capability |
US20100057095A1 (en) | 2004-08-18 | 2010-03-04 | Leonid Orbachevsky | Method of Refraction Surgery of the Eye and a Tool for Implanting Intraocular Refractive Lens |
US7806929B2 (en) | 2004-08-27 | 2010-10-05 | Brown David C | Intracapsular pseudophakic device |
US20060069178A1 (en) | 2004-09-24 | 2006-03-30 | Bausch & Lomb Incorporated | Method for polymerizing ophthalmic devices |
JP4480766B2 (en) | 2004-10-13 | 2010-06-16 | ニューレンズ・リミテッド | Adjustable intraocular lens (AIOL) and AIOL assembly including the same |
US9872763B2 (en) | 2004-10-22 | 2018-01-23 | Powervision, Inc. | Accommodating intraocular lenses |
US7455691B2 (en) | 2004-11-03 | 2008-11-25 | Biovision, Ag | Intraocular and intracorneal refractive lenses |
SE0403091D0 (en) | 2004-12-20 | 2004-12-20 | Amo Groningen Bv | New composition for injectable ophthalmic lenses |
SE0403093D0 (en) | 2004-12-20 | 2004-12-20 | Amo Groningen Bv | New polysiloxanes; synthesis and use thereof |
US20120071972A1 (en) | 2004-12-29 | 2012-03-22 | Iris Ginron Zhao | Multiphase eyecare |
US8216306B2 (en) | 2005-01-13 | 2012-07-10 | Minas Theodore Coroneo | Ocular auto-focusing lenses |
NL1029041C1 (en) | 2005-03-09 | 2006-09-12 | Akkolens Int Bv | Improved construction of an intraocular artificial lens |
JP4937997B2 (en) | 2005-03-30 | 2012-05-23 | ニューレンズ・リミテッド | Accommodating intraocular lens (AIOL) assembly and discrete components therefor |
US20060241752A1 (en) | 2005-04-20 | 2006-10-26 | Israel Henry M | Accommodating multiple lens assembly |
EP1890652B1 (en) | 2005-05-13 | 2017-08-02 | Akkolens International B.V. | Intra-ocular artificial lens for iris-driven accommodation |
NL1029037C2 (en) | 2005-05-13 | 2006-11-14 | Akkolens Int Bv | Artificial intraocular lens with variable optical strength, comprises optical elements with different shapes |
GB0510196D0 (en) | 2005-05-19 | 2005-06-22 | Univ Liverpool | Composition for treatment of a detached retina and method of production thereof |
ES2326742T3 (en) | 2005-05-27 | 2009-10-19 | Wavelight Laser Technologie Ag | INTRAOCULAR LENS |
GB2427484A (en) * | 2005-06-21 | 2006-12-27 | Global Bionic Optics Pty Ltd | Variable power fluid lens with flexible wall |
US7591849B2 (en) | 2005-07-01 | 2009-09-22 | Bausch & Lomb Incorpoted | Multi-component accommodative intraocular lens with compressible haptic |
US20070016293A1 (en) | 2005-07-18 | 2007-01-18 | Alcon, Inc. | Accommodative intraocular lens system |
US8038711B2 (en) | 2005-07-19 | 2011-10-18 | Clarke Gerald P | Accommodating intraocular lens and methods of use |
US20070032868A1 (en) * | 2005-08-08 | 2007-02-08 | Randall Woods | Capsular shape-restoring device |
US7316713B2 (en) | 2005-08-29 | 2008-01-08 | Alcon, Inc. | Accommodative intraocular lens system |
US8034107B2 (en) | 2005-09-01 | 2011-10-11 | Stenger Donald C | Accommodating intraocular lens |
US9629712B2 (en) | 2005-09-01 | 2017-04-25 | Donald C. Stenger | Accommodating intraocular lens |
JP4927371B2 (en) | 2005-09-28 | 2012-05-09 | 興和株式会社 | Intraocular lens |
US9636213B2 (en) | 2005-09-30 | 2017-05-02 | Abbott Medical Optics Inc. | Deformable intraocular lenses and lens systems |
US20070088433A1 (en) | 2005-10-17 | 2007-04-19 | Powervision | Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use |
US8603164B2 (en) | 2005-10-27 | 2013-12-10 | Gholam A. Peyman | Adjustable fluidic telescope |
US20070118216A1 (en) | 2005-11-21 | 2007-05-24 | Joel Pynson | Accommodative intraocular lens |
US7981155B2 (en) | 2005-12-07 | 2011-07-19 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
US20070129800A1 (en) | 2005-12-07 | 2007-06-07 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
US7985253B2 (en) | 2005-12-07 | 2011-07-26 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
JP5068765B2 (en) | 2005-12-14 | 2012-11-07 | ノバルティス アーゲー | Method for producing silicone hydrogel |
US8377125B2 (en) | 2006-04-05 | 2013-02-19 | Anew Optics, Inc. | Intraocular lens with accommodation |
US20070260308A1 (en) | 2006-05-02 | 2007-11-08 | Alcon, Inc. | Accommodative intraocular lens system |
WO2007134019A2 (en) | 2006-05-08 | 2007-11-22 | Bausch & Lomb Incorporated | Accommodative intraocular lens having defined axial compression characteristics |
US7918886B2 (en) | 2006-05-25 | 2011-04-05 | Visioncare Ophthalmic Technologies Inc. | Double insertion intraocular implant |
US20100004742A1 (en) | 2006-08-15 | 2010-01-07 | C7C Vision International Limited | Multiocular Intraocular Lens System |
US20080046077A1 (en) | 2006-08-15 | 2008-02-21 | C&C Vision International Limited | Multiocular Intraocular Lens Systems |
US20080051886A1 (en) | 2006-08-24 | 2008-02-28 | Lin J T | Method and device for vision correction via dual-optics accommodating intraocular lens |
GB0618262D0 (en) | 2006-09-16 | 2006-10-25 | Khoury Elie | Accommodative intra-ocular lens |
ATE524139T1 (en) | 2006-12-13 | 2011-09-15 | Akkolens Int Bv | ACCOMMODATION INTRAOCULAR LENS WITH VARIABLE CORRECTION |
AU2007338100B2 (en) | 2006-12-22 | 2014-01-30 | Amo Groningen Bv | Accommodating intraocular lens, lens system and frame therefor |
WO2008079671A1 (en) | 2006-12-22 | 2008-07-03 | Bausch & Lomb Incorporated | Multi-element accommodative intraocular lens |
JP5207626B2 (en) | 2006-12-26 | 2013-06-12 | 東レ・ダウコーニング株式会社 | Heat curable silicone rubber composition for rubber laminate comprising silicone rubber layer and different rubber layer, rubber laminate and method for producing the same |
US7713299B2 (en) | 2006-12-29 | 2010-05-11 | Abbott Medical Optics Inc. | Haptic for accommodating intraocular lens |
CA2674018C (en) | 2006-12-29 | 2015-05-26 | Advanced Medical Optics, Inc. | Multifocal accommodating intraocular lens |
US8608799B2 (en) | 2007-01-24 | 2013-12-17 | Tekia, Inc. | Umbrella-shaped accommodating artificial ocular lens (AAOL) device |
US8066768B2 (en) | 2007-01-29 | 2011-11-29 | Werblin Research & Development Corp. | Intraocular lens system |
US8066769B2 (en) | 2007-01-29 | 2011-11-29 | Werblin Research & Development Corp. | Intraocular lens system |
US9398949B2 (en) | 2007-01-29 | 2016-07-26 | Emmetropia, Inc. | Intraocular lens system |
EP2111188A4 (en) | 2007-02-02 | 2010-01-13 | Key Medical Technologies Inc | Interfacial refraction accommodating lens (iral) |
US8034106B2 (en) | 2007-02-02 | 2011-10-11 | Adoptics Ag | Interfacial refraction accommodating lens (IRAL) |
US20080306587A1 (en) | 2007-02-21 | 2008-12-11 | Jingjong Your | Lens Material and Methods of Curing with UV Light |
CA2676713C (en) | 2007-02-21 | 2015-11-24 | Powervision, Inc. | Polymeric materials suitable for ophthalmic devices and methods of manufacture |
US7986465B1 (en) | 2007-03-01 | 2011-07-26 | Rhevision Technology, Inc. | Systems and methods for effecting zoom and focus using fluidic adaptive lenses |
EP2120789B1 (en) | 2007-03-05 | 2010-10-06 | Nulens Ltd | Unitary accommodating intraocular lenses (aiols) and discrete base members for use therewith |
EP2617398B1 (en) | 2007-03-13 | 2017-11-15 | Optimedica Corporation | Intraocular lens for improved placement |
US7753953B1 (en) | 2007-03-30 | 2010-07-13 | Kingman Yee | Accommodating intraocular lens system |
WO2009015240A2 (en) | 2007-07-23 | 2009-01-29 | Powervision, Inc. | Lens delivery system |
US8314927B2 (en) | 2007-07-23 | 2012-11-20 | Powervision, Inc. | Systems and methods for testing intraocular lenses |
WO2009015161A2 (en) | 2007-07-23 | 2009-01-29 | Powervision, Inc. | Lens material with uv initiator and uv absorber and methods of curing with uv light |
JP5346022B2 (en) | 2007-07-23 | 2013-11-20 | パワーヴィジョン・インコーポレーテッド | Accommodating intraocular lens and method of use |
US8968396B2 (en) | 2007-07-23 | 2015-03-03 | Powervision, Inc. | Intraocular lens delivery systems and methods of use |
CN101795642B (en) | 2007-07-23 | 2013-11-27 | 力景公司 | Post-implant lens power modification |
US8579971B2 (en) | 2007-08-13 | 2013-11-12 | Garth T. Webb | Inflatable intra ocular lens/lens retainer |
US8377124B2 (en) | 2007-10-02 | 2013-02-19 | Novartis Ag | Two-element system to provide an ease of accommodation with variable-spherical aberration control |
EP2203130B1 (en) | 2007-10-15 | 2018-12-05 | Akkolens International B.V. | Adjustable accommodating intraocular lens and positioning means |
US8012204B2 (en) | 2007-11-14 | 2011-09-06 | Novartis Ag | Accommodative intraocular lens system |
US9156949B2 (en) | 2007-12-21 | 2015-10-13 | Abbott Medical Optics Inc. | Silicone containing polymeric materials |
US8414646B2 (en) | 2007-12-27 | 2013-04-09 | Forsight Labs, Llc | Intraocular, accommodating lens and methods of use |
EP2237744B1 (en) | 2008-01-03 | 2018-04-04 | Forsight Labs, Llc | Intraocular accommodating lens. |
DK3363415T3 (en) | 2008-01-09 | 2019-11-25 | Alcon Lensx Inc | FRAGMENT OF TISSUE WITH CRUMPED PHOTO DESTRUCTIVE LASER |
US20090198326A1 (en) | 2008-01-31 | 2009-08-06 | Medennium Inc. | Accommodative intraocular lens system |
US7998198B2 (en) | 2008-02-07 | 2011-08-16 | Novartis Ag | Accommodative IOL with dynamic spherical aberration |
US8254034B1 (en) | 2008-03-31 | 2012-08-28 | Rhevision Technology, Inc. | Fluidic adaptive lens with a lens membrane having suppressed fluid permeability |
DE102008017592A1 (en) | 2008-04-07 | 2009-10-08 | Carl Zeiss Meditec Ag | Ophthalmological implant, microscopy system and optical detection method for the detection and / or identification of an ophthalmological implant |
NL2001503C2 (en) | 2008-04-21 | 2009-10-22 | Oculentis B V | Intraocular lens. |
CA2726353A1 (en) | 2008-07-24 | 2010-01-28 | Nulens Ltd | Accommodating intraocular lens (aiol) capsules |
US9226798B2 (en) | 2008-10-10 | 2016-01-05 | Truevision Systems, Inc. | Real-time surgical reference indicium apparatus and methods for surgical applications |
AU2009303434A1 (en) | 2008-10-15 | 2010-04-22 | Alcon, Inc. | Accommodating intraocular lens |
US20120232649A1 (en) | 2008-11-20 | 2012-09-13 | Insight Innovations, Llc | Intraocular Lens Cell Migration Inhibition System |
US10010405B2 (en) | 2008-11-26 | 2018-07-03 | Anew Aol Technologies, Inc. | Haptic devices for intraocular lens |
WO2010062972A1 (en) | 2008-11-26 | 2010-06-03 | Anew Optics, Inc. | Intraocular lens optic |
US10299913B2 (en) | 2009-01-09 | 2019-05-28 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
WO2010081093A2 (en) * | 2009-01-09 | 2010-07-15 | Powervision, Inc. | Intraocular lenses and methods of accounting for capsule size variability and post-implant changes in the eye |
US8858626B2 (en) | 2009-02-10 | 2014-10-14 | Novartis Ag | Accommodative intraocular lens system |
US8222360B2 (en) | 2009-02-13 | 2012-07-17 | Visiogen, Inc. | Copolymers for intraocular lens systems |
US8657878B2 (en) * | 2009-02-18 | 2014-02-25 | Hoya Corporation | Interfacial refraction accommodating lens (IRAL) |
US20100211169A1 (en) | 2009-02-19 | 2010-08-19 | Daniel Walter Stanley | Intraocular lens configured to offset optical effects caused by optic deformation |
US9173717B2 (en) | 2009-02-20 | 2015-11-03 | Truevision Systems, Inc. | Real-time surgical reference indicium apparatus and methods for intraocular lens implantation |
WO2010126591A1 (en) | 2009-04-29 | 2010-11-04 | Gobi Ramakrishnan Padmanabhan | Configurations and methods to manufacture solar cell device with larger capture cross section and higher optical utilization efficiency |
US8320049B2 (en) | 2009-07-15 | 2012-11-27 | The Penn State Research Foundation | Tunable liquid gradient refractive index lens device |
US20110029074A1 (en) | 2009-08-03 | 2011-02-03 | Abbott Medical Optics Inc. | Fixation of ophthalmic implants |
EP2473138A4 (en) | 2009-08-31 | 2017-08-16 | PowerVision, Inc. | Lens capsule size estimation |
TWI507183B (en) | 2009-09-04 | 2015-11-11 | Alcon Inc | Intraocular lenses with interlenticular opacification resistance |
US20110071628A1 (en) | 2009-09-24 | 2011-03-24 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US9622852B2 (en) | 2009-10-30 | 2017-04-18 | Akkolens International B.V. | Intraocular lenses for variable focus |
WO2011062826A2 (en) | 2009-11-17 | 2011-05-26 | Lu Kenneth L | Accommodating intraocular lens |
US9114005B2 (en) | 2009-11-17 | 2015-08-25 | Akkolens International B.V. | Accommodative intraocular lens driven by ciliary mass |
US8357196B2 (en) | 2009-11-18 | 2013-01-22 | Abbott Medical Optics Inc. | Mark for intraocular lenses |
US20120245683A1 (en) | 2009-12-04 | 2012-09-27 | Acufocus, Inc. | Corneal implant for refractive correction |
CA2783680C (en) | 2009-12-18 | 2017-05-16 | Novartis Ag | Intraocular lens and associated methods and apparatus |
GB2476480B (en) | 2009-12-22 | 2013-04-03 | Marwan Ghabra | Intraocular implant with a fixed and a pivoting lens |
US20120296424A1 (en) | 2010-01-26 | 2012-11-22 | Nir Betser | Accomodating intraocular lens |
EP2539351B1 (en) | 2010-02-23 | 2017-07-12 | PowerVision, Inc. | Fluid for accommodating intraocular lenses |
DE202010003217U1 (en) | 2010-03-05 | 2011-08-04 | Fluoron Gmbh | Filling material for ophthalmological implants |
US9034035B2 (en) | 2010-03-16 | 2015-05-19 | Mor Research Applications Ltd. | Accommodating intraocular lens assembly |
US8308800B2 (en) | 2010-04-09 | 2012-11-13 | Chu Milton W | Intraocular lenses with high contrast haptics, materials, and methods |
CN102883682A (en) | 2010-04-27 | 2013-01-16 | 雷恩斯根公司 | Accommodating intraocular lens device |
BR112012027060A2 (en) | 2010-04-28 | 2016-07-19 | 3M Innovative Properties Co | silicone based material |
WO2011154972A1 (en) | 2010-06-10 | 2011-12-15 | Ram Srikanth Mirlay | Hinged intraocular lens (iol) and pendulum intraocular lens (iol) with multi optics assembly |
US10736732B2 (en) | 2010-06-21 | 2020-08-11 | James Stuart Cumming | Intraocular lens with longitudinally rigid plate haptic |
BR112012033762A2 (en) | 2010-06-29 | 2018-02-27 | Univ Arizona | accommodation intraocular lens with deformable material |
WO2012006616A2 (en) | 2010-07-09 | 2012-01-12 | Powervision, Inc. | Intraocular lens delivery devices and methods of use |
US20130116781A1 (en) | 2010-08-15 | 2013-05-09 | Joshua Ben Nun | Discrete pre-assembled monolithic aiol assemblages and aiol assemblies including same |
ES2935571T3 (en) | 2011-02-03 | 2023-03-08 | Akkolens Int B V | Haptic combinations for accommodative intraocular lenses |
WO2012106673A1 (en) | 2011-02-04 | 2012-08-09 | Forsight Labs, Llc | Intraocular accommodating lens |
US8867141B2 (en) | 2011-03-18 | 2014-10-21 | Johnson & Johnson Vision Care, Inc. | Lens with multi-concave meniscus wall |
ES2875049T3 (en) | 2011-03-24 | 2021-11-08 | Alcon Inc | Intraocular lens loading systems and methods of use |
WO2012158773A2 (en) | 2011-05-16 | 2012-11-22 | Ico, Inc. | Filling and implanting accommodative intraocular lenses |
US8715345B2 (en) | 2011-05-23 | 2014-05-06 | California Institute Of Technology | Accommodating intraocular lens |
US20140227437A1 (en) | 2011-05-23 | 2014-08-14 | California Institute Of Technology | Accommodating intraocular lens |
AU2012259464B2 (en) | 2011-05-23 | 2017-01-05 | California Institute Of Technology | Accommodating intraocular lens |
US9186243B2 (en) | 2011-05-31 | 2015-11-17 | Novartis Ag | Accommodative intraocular lens and method of implantation |
US8257827B1 (en) | 2011-06-02 | 2012-09-04 | The Regents Of The University Of California | Silicone composition and devices incorporating same |
US8608800B2 (en) | 2011-08-02 | 2013-12-17 | Valdemar Portney | Switchable diffractive accommodating lens |
WO2013016804A1 (en) | 2011-08-03 | 2013-02-07 | Webb Garth T | Negatively pressurized deformable lens |
KR101866873B1 (en) | 2011-08-09 | 2018-06-14 | 삼성전자주식회사 | Device and method for variable curvature |
JP5594262B2 (en) | 2011-08-29 | 2014-09-24 | 信越化学工業株式会社 | Liquid addition-curing fluorosilicone rubber composition and molded product thereof |
WO2013055212A1 (en) | 2011-10-11 | 2013-04-18 | Akkolens International B.V. | Accommodating intraocular lens with optical correction surfaces |
US20130110234A1 (en) | 2011-10-28 | 2013-05-02 | Lauren DeVita | Dual optic accommodating iol with low refractive index gap material |
US10433949B2 (en) | 2011-11-08 | 2019-10-08 | Powervision, Inc. | Accommodating intraocular lenses |
PL2775961T3 (en) | 2011-11-08 | 2019-06-28 | Powervision, Inc. | Accommodating intraocular lenses |
NL2008105C2 (en) | 2012-01-11 | 2013-07-15 | Procornea Holding Bv | Intraocular lens. |
US9364319B2 (en) | 2012-09-25 | 2016-06-14 | Valdemar Portney | Refractive-diffractive switchable optical element |
EP2806828B1 (en) | 2012-01-24 | 2021-07-21 | The Regents of The University of Colorado, A Body Corporate | Modular intraocular lens designs and methods |
US10080648B2 (en) | 2012-01-24 | 2018-09-25 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
US10028824B2 (en) | 2012-01-24 | 2018-07-24 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
US9364316B1 (en) | 2012-01-24 | 2016-06-14 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
US8500806B1 (en) | 2012-01-31 | 2013-08-06 | Andrew F. Phillips | Accommodating intraocular lens |
US8900300B1 (en) | 2012-02-22 | 2014-12-02 | Omega Ophthalmics Llc | Prosthetic capsular bag and method of inserting the same |
EP2827804B1 (en) | 2012-03-21 | 2024-04-03 | Alcon Inc. | Intraocular lens delivery systems |
US9241832B2 (en) | 2012-04-24 | 2016-01-26 | Transcend Medical, Inc. | Delivery system for ocular implant |
US20150105760A1 (en) | 2012-04-30 | 2015-04-16 | Lensgen, Inc. | Method and system for adjusting the refractive power of an implanted intraocular lens |
US9084674B2 (en) | 2012-05-02 | 2015-07-21 | Abbott Medical Optics Inc. | Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity |
WO2013176979A1 (en) | 2012-05-25 | 2013-11-28 | California Institute Of Technology | Accommodating intraocular composite lens and related methods |
JP5872964B2 (en) | 2012-05-29 | 2016-03-01 | 東レ・ダウコーニング株式会社 | Conductive room temperature curable fluorosilicone rubber composition |
FR2992215B1 (en) | 2012-06-21 | 2014-10-31 | Oreal | ANHYDROUS COSMETIC COMPOSITION COMPRISING AN OIL, HYDROPHOBIC SILICA AEROGEL PARTICLES, A HYDROPHILIC ACTIVE INGREDIENT AND AT LEAST ONE SURFACTANT |
DE102012016893A1 (en) | 2012-08-24 | 2014-05-15 | Be Innovative Gmbh | Intraocular lens, in particular capsular bag intraocular lens |
DE102012016892A1 (en) * | 2012-08-24 | 2014-02-27 | Be Innovative Gmbh | Intraocular lens, in particular ciliary intraocular lens |
US8834566B1 (en) | 2012-09-12 | 2014-09-16 | David Jones | Presbyopia-correcting intraocular lens implant |
US9622855B2 (en) | 2012-10-08 | 2017-04-18 | Valdemar Portney | Remote multifocal to monofocal optic conversion |
US20140107459A1 (en) | 2012-10-11 | 2014-04-17 | Alcon Research, Ltd. | Devices, systems, and methods for intraocular measurements |
US9433497B2 (en) | 2012-10-19 | 2016-09-06 | 1Co, Inc. | Systems and methods for customizing adjustable intraocular lenses |
WO2014070331A1 (en) | 2012-10-31 | 2014-05-08 | Novartis Ag | Accommodating intraocular lens with ciliary body activation |
US20140135917A1 (en) | 2012-11-13 | 2014-05-15 | Vision Solutions Technologies, Inc. | Multi-focus intraocular prosthesis |
US9339375B2 (en) | 2012-12-17 | 2016-05-17 | Novartis Ag | Capsule expander devices, systems, and methods for inhibiting capsular opacification and stabilizing the capsule |
WO2014099345A1 (en) | 2012-12-18 | 2014-06-26 | Novartis Ag | Presbyopia-correcting iol using curvature change of an air chamber |
US20140180406A1 (en) | 2012-12-21 | 2014-06-26 | Novartis Ag | Accommodating intraocular lens |
AU2013363516A1 (en) | 2012-12-21 | 2015-05-14 | Novartis Ag | Curvature changing accommodative intraocular lens |
US9186244B2 (en) | 2012-12-21 | 2015-11-17 | Lensgen, Inc. | Accommodating intraocular lens |
CA2889879A1 (en) * | 2012-12-21 | 2014-06-26 | Novartis Ag | Curvature changing accommodative intraocular lens |
WO2014099759A1 (en) | 2012-12-21 | 2014-06-26 | Novartis Ag | Intraocular lens system for monofocal vision at multiple pre-defined focal points |
US20140309734A1 (en) | 2012-12-26 | 2014-10-16 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US9925039B2 (en) | 2012-12-26 | 2018-03-27 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US20140180407A1 (en) * | 2012-12-26 | 2014-06-26 | Rainbow Medical Ltd. | Accommodative intraocular lens |
WO2014111831A1 (en) | 2013-01-15 | 2014-07-24 | Dave, Jagrat Natavar | Toric-diffractive lens |
US10335315B2 (en) | 2013-02-01 | 2019-07-02 | Alcon Lensx, Inc. | Bi-radial patient interface |
US9486311B2 (en) | 2013-02-14 | 2016-11-08 | Shifamed Holdings, Llc | Hydrophilic AIOL with bonding |
US10327889B2 (en) | 2013-02-28 | 2019-06-25 | Richard F. Honigsbaum | Tensioning rings for anterior capsules and accommodative intraocular lenses for use therewith |
US20140257478A1 (en) | 2013-03-07 | 2014-09-11 | Sean J. McCafferty | Accommodating fluidic intraocular lens with flexible interior membrane |
US20140257479A1 (en) | 2013-03-11 | 2014-09-11 | Sean J. McCafferty | Refocusable intraocular lens with flexible aspherical surface |
US9277988B1 (en) | 2013-03-15 | 2016-03-08 | Milton W. Chu | Intraocular lenses with quantum dots |
US10195020B2 (en) | 2013-03-15 | 2019-02-05 | Powervision, Inc. | Intraocular lens storage and loading devices and methods of use |
EP2976042B1 (en) * | 2013-03-21 | 2023-09-13 | Shifamed Holdings, LLC | Accommodating intraocular lens |
US10195018B2 (en) | 2013-03-21 | 2019-02-05 | Shifamed Holdings, Llc | Accommodating intraocular lens |
US9763827B2 (en) | 2013-04-30 | 2017-09-19 | Tear Film Innovations, Inc. | Systems and methods for the treatment of eye conditions |
US9861469B2 (en) | 2013-05-07 | 2018-01-09 | Akkolens International B.V. | Accommodating intraocular lens with haptics for sulcus fixation |
ES2955193T3 (en) | 2013-06-03 | 2023-11-29 | Alcon Inc | Modular intraocular lens designs |
EP2813344B1 (en) | 2013-06-10 | 2016-11-16 | Discma AG | Apparatus and method for fabricating containers |
GB201314428D0 (en) | 2013-08-12 | 2013-09-25 | Qureshi M A | Intraocular lens system and method |
US9937034B2 (en) | 2013-08-20 | 2018-04-10 | Oculentis Holding B.V. | Intraocular lens assembly |
EP3039080B1 (en) | 2013-08-28 | 2022-05-11 | DuPont Toray Specialty Materials Kabushiki Kaisha | Curable silicone composition, cured product thereof, and optical semiconductor device |
EP2851038A1 (en) | 2013-09-24 | 2015-03-25 | Consejo Superior De Investigaciones Cientificas | Intraocular lens with accomodation capacity |
EP3977962A1 (en) | 2013-11-01 | 2022-04-06 | Lensgen, Inc. | Two-part accomodating intraocular lens device |
EP3062741B1 (en) * | 2013-11-01 | 2023-04-26 | Lensgen, Inc. | Accomodating intraocular lens device |
US10011801B2 (en) | 2013-11-20 | 2018-07-03 | Dow Silicones Corporation | Organosiloxane compositions |
US9962226B2 (en) | 2013-11-28 | 2018-05-08 | Alcon Pharmaceuticals Ltd. | Ophthalmic surgical systems, methods, and devices |
ES2699994T3 (en) | 2013-12-04 | 2019-02-13 | Novartis Ag | Soft hydrophobic acrylic materials |
WO2015094485A1 (en) | 2013-12-20 | 2015-06-25 | Novartis Ag | Accommodating intraocular lens |
WO2015099879A2 (en) | 2013-12-23 | 2015-07-02 | Novartis Ag | Accommodating intraocular lens |
EP4215159A1 (en) | 2014-02-18 | 2023-07-26 | Alcon Inc. | Modular intraocular lens designs, tools and methods |
WO2015134058A1 (en) | 2014-03-07 | 2015-09-11 | Mccafferty Sean | Refocusable lens system with mutually-applanating internal surfaces |
AU2015228548B2 (en) | 2014-03-10 | 2019-11-21 | Amo Groningen B.V. | Piggyback intraocular lens that improves overall vision where there is a local loss of retinal function |
US10285805B2 (en) | 2014-03-28 | 2019-05-14 | Forsight Labs, Llc | Accommodating intraocular lens |
US10010408B2 (en) | 2014-04-04 | 2018-07-03 | Alcon Pharmaceuticals, Ltd. | Intraocular lens inserter |
US9333072B2 (en) | 2014-04-29 | 2016-05-10 | Chukyo Medical Co., Inc. | Intraocular lens |
CA2952809C (en) | 2014-06-19 | 2019-11-26 | Omega Ophthalmics Llc | Prosthetic capsular devices, systems, and methods |
WO2016014940A1 (en) | 2014-07-24 | 2016-01-28 | Anew Iol Technologies, Inc. | Haptic devices for intraocular lens |
US10004596B2 (en) | 2014-07-31 | 2018-06-26 | Lensgen, Inc. | Accommodating intraocular lens device |
US20160051361A1 (en) | 2014-08-21 | 2016-02-25 | Emmetrope Incorporated | Accommodating Intraocular Lens |
WO2016033217A1 (en) | 2014-08-26 | 2016-03-03 | Shifamed Holdings, Llc | Accommodating intraocular lens |
US11109957B2 (en) | 2014-09-22 | 2021-09-07 | Onpoint Vision, Inc. | Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method |
US10159562B2 (en) | 2014-09-22 | 2018-12-25 | Kevin J. Cady | Intraocular pseudophakic contact lenses and related systems and methods |
US11938018B2 (en) | 2014-09-22 | 2024-03-26 | Onpoint Vision, Inc. | Intraocular pseudophakic contact lens (IOPCL) for treating age-related macular degeneration (AMD) or other eye disorders |
US10945832B2 (en) | 2014-09-22 | 2021-03-16 | Onpoint Vision, Inc. | Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method |
US10299910B2 (en) | 2014-09-22 | 2019-05-28 | Kevin J. Cady | Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method |
EP3197462A4 (en) | 2014-09-23 | 2018-05-30 | Lensgen, Inc | Polymeric material for accommodating intraocular lenses |
US20160106534A1 (en) | 2014-10-15 | 2016-04-21 | Charles DeBoer | Methods and intraocular lens for counteracting astigmatism aberrations |
US10709551B2 (en) | 2014-12-27 | 2020-07-14 | Jitander Dudee | Accommodating intraocular lens assembly |
US10265163B2 (en) | 2014-12-27 | 2019-04-23 | Jitander Dudee | Accommodating intraocular lens assembly |
WO2016113634A1 (en) | 2015-01-16 | 2016-07-21 | Marwan Ghabra | Variable strength intraocular lens and method of using same |
AU2015380300B2 (en) | 2015-01-30 | 2020-01-02 | Alcon Inc. | Modular intraocular lens designs |
US9358103B1 (en) | 2015-02-10 | 2016-06-07 | Omega Ophthalmics Llc | Prosthetic capsular devices, systems, and methods |
AU2015383131B2 (en) | 2015-02-16 | 2020-05-21 | Alcon Inc. | Curvature-changing, accommodative intraocular lenses with expandable peripheral reservoirs |
CN107249516B (en) | 2015-03-03 | 2019-11-22 | 诺华股份有限公司 | Two lens, Curvature varying modulability IOL |
US20160287380A1 (en) | 2015-03-30 | 2016-10-06 | Wendian Shi | Fluid-filled implantable structures with internal surface-modifying components and related methods |
GB2554608B (en) | 2015-06-05 | 2022-04-06 | Novartis Ag | Flow-through paramagnetic particle-based cell separation and paramagnetic particle removal |
US10182905B2 (en) | 2015-06-10 | 2019-01-22 | Richard F. Honigsbaum | Anterior-posterior-capsule-actuated hydraulic accommodative intraocular lenses and lens systems |
CN114452440A (en) | 2015-06-10 | 2022-05-10 | 爱尔康公司 | Intraocular lens materials and compositions |
US10799340B2 (en) | 2015-08-10 | 2020-10-13 | Alcon Inc. | Intraocular lens having a capsular ring for inhibiting capsular opacification |
US11173008B2 (en) | 2015-11-01 | 2021-11-16 | Alcon Inc. | Illuminated ophthalmic cannula |
AU2016349363B2 (en) | 2015-11-04 | 2022-01-27 | Alcon Inc. | Modular intraocular lens designs, tools and methods |
CA3001477A1 (en) | 2015-11-06 | 2017-05-11 | Powervision, Inc. | Accommodating intraocular lenses and methods of manufacturing |
ES2617579B1 (en) | 2015-11-16 | 2018-04-10 | Lens Undergone Zonula Global, S.L. | IMPROVED ACCOMMODATION INTRAOCULAR LENS |
US11141263B2 (en) | 2015-11-18 | 2021-10-12 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lens |
CN108472129B (en) | 2015-11-18 | 2021-09-24 | 施菲姆德控股有限责任公司 | Combined accommodating intraocular lens |
EP3383320A4 (en) | 2015-12-01 | 2019-08-21 | Lensgen, Inc | Accommodating intraocular lens device |
US10441157B2 (en) | 2015-12-02 | 2019-10-15 | Novartis Ag | Optical fiber having proximal taper for ophthalmic surgical illumination |
US9931202B2 (en) | 2016-03-08 | 2018-04-03 | Novartis Ag | Dual optic, curvature changing accommodative IOL having a fixed disaccommodated refractive state |
US11071449B2 (en) | 2016-03-31 | 2021-07-27 | Alcon Inc. | Visualization system for ophthalmic surgery |
US11045309B2 (en) | 2016-05-05 | 2021-06-29 | The Regents Of The University Of Colorado | Intraocular lens designs for improved stability |
US10526353B2 (en) | 2016-05-27 | 2020-01-07 | Lensgen, Inc. | Lens oil having a narrow molecular weight distribution for intraocular lens devices |
WO2017208230A1 (en) | 2016-06-01 | 2017-12-07 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US10327886B2 (en) | 2016-06-01 | 2019-06-25 | Rainbow Medical Ltd. | Accomodative intraocular lens |
JP2019520886A (en) | 2016-06-06 | 2019-07-25 | オメガ・オフサルミックス・エルエルシーOmega Ophthalmics LLC | Artificial lens capsule device, system and method |
TW201802001A (en) | 2016-06-06 | 2018-01-16 | 耐斯泰克公司 | Tamper evidence means for a container cap and container cap comprising such tamper evidence means |
US10159566B2 (en) | 2016-09-26 | 2018-12-25 | Novartis Ag | Heat tunable intraocular lens |
US10111746B2 (en) | 2016-10-21 | 2018-10-30 | Omega Ophthalmics Llc | Prosthetic capsular devices, systems, and methods |
US11523898B2 (en) | 2016-10-28 | 2022-12-13 | Forsight Vision6, Inc. | Accommodating intraocular lens and methods of implantation |
US11110005B2 (en) | 2016-11-17 | 2021-09-07 | Alcon Inc. | Medical instrument with an integrated optical fiber |
US11083567B2 (en) | 2016-12-12 | 2021-08-10 | Richard F. Honigsbaum | Bifurcated haptic aligner-actuators for accommodative intraocular lenses and exemplary AIOLS aligned and actuated thereby |
CN113197708A (en) | 2016-12-23 | 2021-08-03 | 施菲姆德控股有限责任公司 | Multi-piece accommodating intraocular lenses and methods of making and using same |
US10350056B2 (en) | 2016-12-23 | 2019-07-16 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lenses and methods for making and using same |
US10441411B2 (en) | 2016-12-29 | 2019-10-15 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US11000367B2 (en) | 2017-01-13 | 2021-05-11 | Alcon Inc. | Intraocular lens injector |
US10548719B2 (en) | 2017-03-01 | 2020-02-04 | Eye-Pcr B.V. | Devices for reconstruction of a lens capsule after cataract surgery |
BR112019018939A2 (en) | 2017-03-13 | 2020-04-22 | Kejako Sa | accommodating lens device |
US10918476B2 (en) | 2017-03-30 | 2021-02-16 | Verily Life Sciences Llc | Electrowetting intraocular lens with isotonic aqueous phase |
US11409134B2 (en) | 2017-04-19 | 2022-08-09 | Amo Groningen B.V. | Electrowetting and photo curing for manufacturing of ophthalmic lenses |
US10917543B2 (en) | 2017-04-24 | 2021-02-09 | Alcon Inc. | Stereoscopic visualization camera and integrated robotics platform |
US11000363B2 (en) | 2017-05-02 | 2021-05-11 | Alcon Inc. | Accommodating intraocular lens devices, systems, and methods using an opaque frame |
US11197752B2 (en) | 2017-05-05 | 2021-12-14 | Verily Life Sciences Llc | Situ filling and sealing of electrowetting intraocular lenses |
EP3634308A4 (en) | 2017-05-30 | 2021-02-24 | Shifamed Holdings, LLC | Surface treatments for accommodating intraocular lenses and associated methods and devices |
CN110996850B (en) | 2017-06-07 | 2023-02-17 | 施菲姆德控股有限责任公司 | Intraocular lens capable of adjusting optical power |
US11382736B2 (en) | 2017-06-27 | 2022-07-12 | Alcon Inc. | Injector, intraocular lens system, and related methods |
CN113558818A (en) | 2017-07-11 | 2021-10-29 | 正点视界公司 | Artificial pseudolens contact lenses with mechanisms for anterior leaflet fixation through the capsular wall and associated systems and methods |
US10716661B2 (en) | 2017-07-17 | 2020-07-21 | Verily Life Sciences Llc | Accommodating intraocular lens with meniscus |
ES2946038T3 (en) | 2017-07-24 | 2023-07-12 | Alcon Inc | Ophthalmic lens having transformed sinusoidal phase shift structures |
WO2019027845A1 (en) | 2017-07-31 | 2019-02-07 | Douglas Michael Ackermann | Pupillary accommodating intraocular lens |
US20190069989A1 (en) | 2017-09-06 | 2019-03-07 | Verily Life Sciences Llc | Multipart electrowetting intraocular lens for in-situ assembly |
US11707354B2 (en) | 2017-09-11 | 2023-07-25 | Amo Groningen B.V. | Methods and apparatuses to increase intraocular lenses positional stability |
CN117323062A (en) | 2017-11-01 | 2024-01-02 | 爱尔康公司 | Stabilization of intraocular lenses and peripheral portions |
US11111055B2 (en) | 2017-12-14 | 2021-09-07 | Alcon Inc. | Basket for carrying a contact lens during its treatment in a bath |
US10898316B2 (en) | 2018-03-01 | 2021-01-26 | Jellisee Ophthalmics Inc | Intraocular lens |
BR112020017335A2 (en) | 2018-03-29 | 2020-12-15 | Société des Produits Nestlé S.A. | CONTROLLED POSITIONING IN FOOD PROCESSOR |
US11930964B2 (en) | 2018-03-29 | 2024-03-19 | Societe Des Produits Nestle S.A. | Heat management for food processor |
US11660180B2 (en) | 2018-04-25 | 2023-05-30 | The Regents Of The University Of California | Intraoperative assessment of implant positioning |
EP3801693A1 (en) | 2018-05-24 | 2021-04-14 | Novartis AG | Automatic drug delivery device |
WO2019236908A1 (en) | 2018-06-07 | 2019-12-12 | Lensgen, Inc. | Intraocular lens devices and related methods |
WO2020018869A1 (en) | 2018-07-19 | 2020-01-23 | Alcon Inc. | Radially repulsive magnetic bearing for self-aligning elements of coupled platforms |
WO2020109865A1 (en) | 2018-11-29 | 2020-06-04 | Novartis Ag. | High-throughput multi-organ perfusion models |
US11298221B2 (en) | 2018-12-20 | 2022-04-12 | Alcon Inc. | Three-lens intraocular lens system |
BR112021019254A2 (en) | 2019-03-25 | 2021-11-30 | Akkolens Int B V | Combination intraocular lenses for restoration of refraction and accommodation and related methods |
US11166844B2 (en) | 2019-04-25 | 2021-11-09 | Alcon Inc. | Retinal patch graft and biopsy device |
EP3962412A1 (en) | 2019-05-03 | 2022-03-09 | Jellisee Ophthalmics Inc. | Intraocular lenses with shape-changing optics |
EP4017420A1 (en) | 2019-09-30 | 2022-06-29 | Alcon Inc. | Soft tip plunger |
JP2022550467A (en) | 2019-10-04 | 2022-12-01 | アルコン インコーポレイティド | Adjustable intraocular lenses and post-operative adjustment methods for intraocular lenses |
CA3152304A1 (en) | 2019-10-04 | 2021-04-08 | Andrew R. WALZ | Accommodating intraocular lenses with toric surface |
JP2023500039A (en) | 2019-11-01 | 2023-01-04 | アルコン インコーポレイティド | Force fit eye cannula with reinforced surface |
AU2020377552A1 (en) | 2019-11-04 | 2022-04-07 | Alcon Inc. | Irrigation sleeve for ophthalmic procedures |
CN114829479A (en) | 2019-11-07 | 2022-07-29 | 雷恩斯根公司 | Silicone oil terpolymers for intraocular lens devices |
EP4065356A1 (en) | 2019-11-26 | 2022-10-05 | Alcon Inc. | Method for producing contact lenses |
AU2020398888A1 (en) | 2019-12-11 | 2022-06-16 | Lensgen, Inc. | Fluid lens component for intraocular lens and methods of preparing the same |
KR20220117195A (en) | 2019-12-17 | 2022-08-23 | 온포인트 비젼 인코포레이티드 | Intraocular intraocular lens contact lenses having a mechanism for anchoring by the anterior leaflet of the capsular body wall, related systems and methods |
TW202132823A (en) | 2019-12-18 | 2021-09-01 | 瑞士商愛爾康公司 | Hybrid diffractive and refractive contact lens for treatment of myopia |
TW202125041A (en) | 2019-12-18 | 2021-07-01 | 瑞士商愛爾康公司 | Hybrid diffractive and refractive contact lens |
US11806105B2 (en) | 2020-01-21 | 2023-11-07 | Alcon Inc. | Vitreoretinal surgery dexterity enhancement system |
US20210244488A1 (en) | 2020-02-12 | 2021-08-12 | Alcon Inc. | Ophthalmic surgical systems with graphical user interfaces based upon setup conditions |
WO2021186383A1 (en) | 2020-03-19 | 2021-09-23 | Alcon Inc. | Embedded silicone hydrogel contact lenses |
MX2022011568A (en) | 2020-03-19 | 2022-10-18 | Alcon Inc | High refractive index siloxane insert materials for embedded contact lenses. |
MX2022011571A (en) | 2020-03-19 | 2022-10-18 | Alcon Inc | Insert materials with high oxygen permeability and high refractive index. |
US11833770B2 (en) | 2020-03-19 | 2023-12-05 | Alcon Inc. | Method for producing embedded or hybrid hydrogel contact lenses |
EP4157618A1 (en) | 2020-05-29 | 2023-04-05 | Alcon Inc. | Carrier for carrying an ophthalmic lens during its treatment in a bath |
US20210369106A1 (en) | 2020-05-29 | 2021-12-02 | Alcon Inc. | Selection of intraocular lens based on a predicted subjective outcome score |
BR112022022816A2 (en) | 2020-06-02 | 2022-12-13 | Alcon Inc | HYDRAULIC DELIVERY OF SURGICAL IMPLANTS |
JP2023535314A (en) | 2020-07-15 | 2023-08-17 | アルコン インコーポレイティド | Aerosol reducing collar for ophthalmic surgery |
-
2016
- 2016-12-01 EP EP16871532.4A patent/EP3383320A4/en active Pending
- 2016-12-01 CN CN202110377284.6A patent/CN113180886A/en active Pending
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- 2016-12-01 WO PCT/US2016/064491 patent/WO2017096087A1/en active Application Filing
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2018
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-
2021
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-
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4585457A (en) * | 1985-05-16 | 1986-04-29 | Kalb Irvin M | Inflatable intraocular lens |
US5306297A (en) * | 1992-07-06 | 1994-04-26 | Kabi Pharmacia Ophthalmics, Inc. | Intraocular lens haptic with enlarged anchoring head |
US20050085907A1 (en) * | 2000-02-16 | 2005-04-21 | Humanoptics Ag | Intraocular implant and an artificial lens device |
US20030204256A1 (en) * | 2002-04-29 | 2003-10-30 | Qun Peng | Accommodative intraocular lens |
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WO2017096087A1 (en) | 2017-06-08 |
EP3383320A1 (en) | 2018-10-10 |
AU2021290373A1 (en) | 2022-02-03 |
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CN108778185A (en) | 2018-11-09 |
CN108778185B (en) | 2021-04-27 |
JP2018535779A (en) | 2018-12-06 |
AU2016362384A1 (en) | 2018-07-19 |
US20210401570A1 (en) | 2021-12-30 |
US20180271645A1 (en) | 2018-09-27 |
CN113180886A (en) | 2021-07-30 |
US11471270B2 (en) | 2022-10-18 |
JP7260592B2 (en) | 2023-04-18 |
AU2016362384B2 (en) | 2021-10-07 |
JP6900376B2 (en) | 2021-07-07 |
EP3383320A4 (en) | 2019-08-21 |
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