IL290086B2 - Intraocular lens holding devices - Google Patents

Intraocular lens holding devices

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Publication number
IL290086B2
IL290086B2 IL290086A IL29008622A IL290086B2 IL 290086 B2 IL290086 B2 IL 290086B2 IL 290086 A IL290086 A IL 290086A IL 29008622 A IL29008622 A IL 29008622A IL 290086 B2 IL290086 B2 IL 290086B2
Authority
IL
Israel
Prior art keywords
actuators
iol
actuator
interaction region
activated
Prior art date
Application number
IL290086A
Other languages
Hebrew (he)
Other versions
IL290086A (en
Original Assignee
Eyemed Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eyemed Tech Ltd filed Critical Eyemed Tech Ltd
Priority to IL290086A priority Critical patent/IL290086B2/en
Publication of IL290086A publication Critical patent/IL290086A/en
Priority to PCT/IL2023/050075 priority patent/WO2023139589A1/en
Publication of IL290086B2 publication Critical patent/IL290086B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1629—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/1689—Intraocular lenses having supporting structure for lens, e.g. haptics having plate-haptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Prostheses (AREA)

Description

INTRAOCULAR LENS HOLDING DEVICES TECHNOLOGICAL FIELD The present invention is in the field of medical devices, and relates specifically to devices configured for holding intraocular lenses in vivo.
BACKGROUND Various medical conditions related to vision and eyesight are treated by replacement of the natural eye lens with an artificial intraocular lens (IOL). Eye-related problems such as cataract, eye trauma, vision refractive errors including far-sightedness (hyperopia), near-sightedness (myopia) and astigmatism can be solved by IOL replacement surgery. This treatment can be beneficial in other eye conditions in people who are not eligible for laser treatment.
Cataracts are the most prevalent ocular disease worldwide, being the cause of half of blindness and third of visual impairment in the world. About twenty-five million patients worldwide undergo cataract surgery on annual basis.
The typically implanted IOL provides selected focal length and optical power that should allow the patient to have a fairly good vision. However, it is often difficult to predict the exact characteristics of the lens necessary to correct the impaired vision. For example, currently, less than 50% of patients achieve their targeted vision after treatment, even with state-of-the-art multi-focal and other presbyopia correcting intraocular lenses, resulting in that post-surgery patients should often wear glasses for reading or distance vision.
Although it is a frequent surgical procedure, IOL replacement surgery involves several challenges, for example: prediction of exact lens characteristics (ELP); lens-positioning error during the surgery; tilt or shift after the surgery and during eye healing process; and change of the corneal cylinder in the elderly. There are a few types of IOLs 25 used to correct visual impairment, such as Mono-focal, Multi-focal and Toric (with possible combinations in the same lens). Following the installation and healing process, all kinds of IOL may move and deviate from the designed optical axis, hence requiring compensation by optimizing the IOL location inside the lens capsule. Modification of the IOL location may be needed around the optical axis of the IOL, to correct for astigmatism issues, or along the optical axis of the IOL, to correct focusing problems. There are several techniques, both invasive and non-invasive, used to implement the compensations, such as repeated surgery to displace the IOL; use of a unique UV sensitive polymer that enables compensation by post deforming of the lens; and/or modification of the IOL shape by use of laser radiation.
GENERAL DESCRIPTION The present invention provides techniques for post adjustment and optimization of position of an intraocular lens (IOL) that has been already implanted inside the lens capsule. The described techniques, systems and devices enable non-invasive, remote, reversible and repeated corrections of the IOL position, enabling the procedure to be performed relatively easily and in short time, in the clinic, while eliminating the need for additional invasive surgical procedures. The invention provides IOL holding/supporting systems/devices (e.g. in the form of a cradle) that include/integrate a movement system/mechanism/assembly operable to displace and adjust the position of the IOL. The movement system/mechanism/assembly is configured to be activated remotely from outside the eye and apply correction of the IOL position in at least one of the angular (xy plane, theta) and axial (z) directions, i.e. by rotating the IOL and/or changing its optical power respectively. It is noted, that according to the invention, the displacement in the axial direction can be achieved by using a helical path of displacement such that rotation about the optical axis can result in displacement along the optical axis. The invention enables doctors to precisely adjust the position of the IOL based on the exact amount of visual correction needed to achieve the desired vision. The systems/devices disclosed herein are advantageously miniature enabling remote access to the integrated movement system/mechanism through the pupil of the eye. The diameter of the pupil extends between about 2mm to 4mm in light conditions and between about 4mm to 8mm in dark conditions. Accordingly, the described systems/devices allow for accommodating an IOL having a diameter in the range of about 3.5-4.5mm. Consequently, the perimeter in which the movement system/mechanism of the systems/devices should work to displace the IOL is, for example, about π· 4mm (supposing a relatively circular shape having a diameter of 4mm), and as the accuracy of needed angular correction is about 0.5º- 1º this means that the step of angular distance of the corrections is about 0.017-0.035mm. The technique of the present invention enables achieving step distances in the described range while overcoming the limitations of manufacturing movement systems/mechanisms that enable such tiny step angular/distance corrections. Additionally, the described systems and devices are elastic and foldable, at least in a working range of temperature, hence facilitating insertion and implantation in the eye capsule. Thus, according to one aspect, there is provided a device configured to be implanted in a lens capsule of a human eye and securely hold an intraocular lens (IOL) and operable to rotate the IOL, around an optical axis of the IOL, by absorbing energy from a remote energy source, the device comprising: - a stator portion configured to be fixedly positioned inside the lens capsule; - a rotor portion configured to be fixedly attached to the IOL; and - a movement system operable to cause incremental rotation of the rotor portion and the IOL, around the optical axis of the IOL, with respect to the stator portion, the movement system comprising a plurality of actuators having a fixed spatial relationship with the rotor portion and at least one interaction region associated with the plurality of actuators and having a fixed spatial relationship with the stator portion, the plurality of actuators and the at least one interaction region being aligned such that at each given time each actuator of the plurality of actuators is aligned differently with respect to the interaction region associated therewith, and is configured, when being activated by said remote energy source to engage with the associated interaction region, to cause the IOL to rotate with a different incremental rotation having either a different angular distance or angular direction. In some embodiments, the plurality of actuators and the associated at least one interaction region are aligned such that at each given time after an actuator of the plurality of actuators is activated by said remote energy source to engage with the associated interaction region and cause the IOL to rotate with a specific incremental rotation having specific angular distance and direction, a subsequent actuator of the plurality of actuators becomes aligned with its associated interaction region and configured, when being activated by said remote energy source to engage with its associated interaction region, to cause the IOL to rotate with the same specific incremental rotation having the same specific angular distance and direction. In some embodiments, the plurality of actuators and the associated at least one interaction region are aligned such that after an actuator is activated to engage with the associated interaction region and cause the IOL to rotate with a specific incremental rotation having specific angular distance and direction, the actuator becomes misaligned with respect to the associated interaction region such that a subsequent activation of the actuator to engage with the associated interaction region results in zero incremental rotation of the IOL. In some embodiments, the plurality of actuators comprise two actuators spaced- apart with a first distance therebetween, and said associated at least one interaction region comprise two respective interaction regions spaced apart with a second distance therebetween being different than said first distance. In some embodiments, the plurality of actuators comprise at least three actuators spaced-apart with a variable distance therebetween, and said associated at least one interaction region comprise at least three respective interaction regions spaced apart with a constant distance therebetween. In some embodiments, the plurality of actuators comprise at least three actuators spaced-apart with a constant distance therebetween, and said associated at least one interaction region comprise at least three respective interaction regions spaced apart with a variable distance therebetween. In some embodiments, the variable distance is characterized by a fixed increasing pitch between each two adjacent actuators of the at least three actuators or each two adjacent interaction regions of the at least three respective interaction regions. In some embodiments, at least some actuators of said plurality of actuators when being sequentially activated in a specific activation order, to sequentially engage with the associated interaction region, they cause the IOL to rotate in sequential incremental rotations having equal angular distances and same angular direction.
In some embodiments, at least some actuators of said plurality of actuators are unidirectional such that when being individually activated, to engage with the associated at least one interaction region, they cause the IOL to rotate in same angular direction. The unidirectional actuators may comprise a first group of unidirectional actuators operable to cause the IOL to rotate in clockwise direction, when being sequentially activated to engage with the associated interaction region, and a second group of unidirectional actuators operable to cause the IOL to rotate in counterclockwise direction, when being sequentially activated to engage with the associated at least one interaction region. In some embodiments, at least some actuators of said plurality of actuators are bidirectional such that when being individually activated to engage with the associated at least one interaction region, they cause the IOL to rotate either in clockwise or counterclockwise angular direction based on their temporary alignment with respect to the associated interaction region. In some embodiments, at least some actuators of the plurality of actuators each having a length dimension defining the actuator as being unidirectional actuator or bidirectional actuator configured, when being activated by said remote energy source, to cause the IOL to rotate in respectively one or two angular directions. In some embodiments, each actuator of said plurality of actuators comprises an actuator activable portion being reversibly shiftable between a first resting spatial configuration, and a second activated spatial configuration when being activated by said remote energy source, thereby respectively enabling the actuator to engage with and disengage from the associated interaction region. Each actuator of said plurality of actuators may comprise an actuator elastic portion in communication with said actuator activable portion, the actuator elastic portion being operable to return the actuator activable portion from said second activated spatial configuration into said first resting spatial configuration once the actuator activable portion is no more activated by said remote energy source. The actuator elastic portion may be operable to engage with the associated interaction region, when said actuator activable portion is activated by said remote energy source, to cause the IOL to rotate with the incremental rotation. In some embodiments, the actuator activable portion comprises a shape-memory material operable to provide said first resting spatial configuration and second activated spatial configuration. The shape-memory material may comprise nitinol or/and a bi-metal.
In some embodiments, the stator portion comprises super-elastic material. In some embodiments, the rotor portion comprises super-elastic material. In some embodiments, the super-elastic material comprises nitinol or/and a bi-metal. In some embodiments, the device is foldable such that it can be passed through a cross-section of about 2.54mm or about 1.8mm circular diameter. In some embodiments, the incremental rotation has an angular distance being equivalent to or greater than an angle of 0.3º. In some embodiments, one or more of said at least one interaction region is(are) defined by a series of teeth protrusions. Each tooth protrusion may define an incremental rotation of angular distance being equivalent to or greater than an angle of 0.6º. In some embodiments, the device comprises one or more marks enabling to identify each actuator of the plurality of actuators to thereby enable which actuator is to be activated. According to another aspect, there is provided an IOL adjustment system comprising: - a device having any one of the configurations described above; and - a remote energy source configured and operable to provide said energy to said plurality of actuators. In some embodiments, the remote energy source is configured and operable to provide said energy in the form of heat. The remote energy source may comprise one or more of the following: a radiating element, a laser source. In some embodiments, the laser source is configured and operable to provide continuous laser radiation. In some embodiments, the laser source is configured as an Argon laser source operable to provide light of a green spectrum. In some embodiments, the laser source is configured and operable to provide laser power between 0.1 – 5 watt, and laser pulse width between 200-1000ms. In some embodiments, the remote energy source comprises an electromagnetic radiation transmitter and said plurality of actuators comprise corresponding electromagnetic radiation receivers.
BRIEF DESCRIPTION OF THE DRAWINGS In order to better understand the subject matter that is disclosed herein and to exemplify how it may be carried out in practice, embodiments will now be described, by way of non-limiting example only, with reference to the accompanying drawings, in which: Figs. 1A-1G4 illustrate a first non-limiting example of a device configured to hold an IOL and operable to remotely adjust position of the IOL after it has been implanted inside an eye, in accordance with the invention; Figs. 2A-2D illustrate a second non-limiting example of a device configured to hold an IOL and operable to remotely adjust position of the IOL after it has been implanted inside an eye, in accordance with the invention; Figs. 3A-3D illustrate a third non-limiting example of a device configured to hold an IOL and operable to remotely adjust position of the IOL after it has been implanted inside an eye, in accordance with the invention; Figs. 4A-4C illustrate a fourth non-limiting example of a device configured to hold an IOL and operable to remotely adjust position of the IOL after it has been implanted inside an eye, in accordance with the invention; Figs. 5A-5B illustrate a fifth non-limiting example of a device configured to hold an IOL and operable to remotely adjust position of the IOL after it has been implanted inside an eye, in accordance with the invention; and Figs. 6A-6G illustrate a sixth non-limiting example of a device configured to hold an IOL and operable to remotely adjust position of the IOL after it has been implanted inside an eye, in accordance with the invention.

Claims (33)

- 29 – 290086/ CLAIMS:
1. A device configured to be implanted in a lens capsule of a human eye and securely hold an intraocular lens (IOL) and operable to rotate the IOL, around an optical axis of the IOL, by absorbing energy from a remote energy source, the device comprising: - a stator portion configured to be fixedly positioned inside the lens capsule; - a rotor portion configured to be fixedly attached to the IOL; and - a movement system operable to cause incremental rotation of the rotor portion and the IOL, around the optical axis of the IOL, with respect to the stator portion, the movement system comprising a plurality of actuators having a fixed spatial relationship with the rotor portion and at least one interaction region associated with the plurality of actuators and having a fixed spatial relationship with the stator portion, the plurality of actuators comprise at least two actuators operable to cause the rotation of the rotor portion and the IOL in each of the clockwise and counterclockwise angular directions, the plurality of actuators and the at least one interaction region being aligned such that, at each given moment in time, each actuator of the plurality of actuators is aligned differently with respect to the interaction region associated therewith and faces a different interaction point on the associated interaction region, and is configured, when being activated by said remote energy source, to engage with the associated interaction region at the respective interaction point and to cause the IOL to rotate with a respectively different incremental rotation having either a different angular distance or a different angular direction.
2. The device according to claim 1, wherein said plurality of actuators and the associated at least one interaction region are aligned such that at each given time after an actuator of the plurality of actuators is activated by said remote energy source to engage with the associated interaction region at the respective interaction point and cause the IOL to rotate with a specific incremental rotation having specific angular distance and direction, a subsequent actuator of the plurality of actuators becomes aligned with its associated interaction region and configured, when being activated by said remote energy - 30 – 290086/source, to engage with its associated interaction region, to cause the IOL to rotate with the same specific incremental rotation having the same specific angular distance and direction.
3. The device according to claim 1 or 2, wherein said plurality of actuators and the associated at least one interaction region are aligned such that after an actuator is activated to engage with the associated interaction region and cause the IOL to rotate with a specific incremental rotation having specific angular distance and direction, the actuator becomes misaligned with respect to the associated interaction region such that an immediate subsequent activation of the actuator to engage with the associated interaction region results in zero incremental rotation of the IOL.
4. The device according to any one of the preceding claims, wherein said plurality of actuators comprise two actuators spaced-apart with a first distance therebetween, and said associated at least one interaction region comprise two respective interaction regions spaced apart with a second distance therebetween being different than said first distance.
5. The device according to any one of the claims 1 to 3, wherein said plurality of actuators comprise at least three actuators spaced-apart with a variable distance therebetween, and said associated at least one interaction region comprise at least three respective interaction regions spaced apart with a constant distance therebetween.
6. The device according to any one of the claims 1 to 3, wherein said plurality of actuators comprise at least three actuators spaced-apart with a constant distance therebetween, and said associated at least one interaction region comprise at least three respective interaction regions spaced apart with a variable distance therebetween.
7. The device according to claim 5 or 6, wherein said variable distance is characterized by a fixed increasing pitch between each two adjacent actuators of the at least three actuators or each two adjacent interaction regions of the at least three respective interaction regions. - 31 – 290086/
8. The device according to any one of the preceding claims, wherein at least some actuators of said plurality of actuators when being sequentially activated in a specific activation order, to sequentially engage with the associated interaction region, they cause the IOL to rotate in sequential incremental rotations having equal angular distances and same angular direction.
9. The device according to any one of the preceding claims, wherein at least some actuators of said plurality of actuators are unidirectional such that when being individually activated, to engage with the associated at least one interaction region, they cause the IOL to rotate in same angular direction.
10. The device according to claim 9, wherein said unidirectional actuators comprise a first group of unidirectional actuators operable to cause the IOL to rotate in clockwise direction, when being sequentially activated to engage with the associated interaction region, and a second group of unidirectional actuators operable to cause the IOL to rotate in counterclockwise direction, when being sequentially activated to engage with the associated at least one interaction region.
11. The device according to any one of the claims 1 to 8, wherein at least some actuators of said plurality of actuators are bidirectional such that when being individually activated to engage with the associated at least one interaction region, they cause the IOL to rotate either in clockwise or counterclockwise angular direction based on their temporary alignment with respect to the associated interaction region.
12. The device according to any one of the preceding claims, wherein at least some actuators of the plurality of actuators each having a length dimension defining the actuator as being unidirectional actuator or bidirectional actuator configured, when being activated by said remote energy source, to cause the IOL to rotate in respectively one or two angular directions.
13. The device according to any one of the preceding claims, wherein each actuator of said plurality of actuators comprises an actuator activable portion being reversibly shiftable between a first resting spatial configuration, and a second activated spatial configuration when being activated by said remote energy source, thereby respectively enabling the actuator to engage with and disengage from the associated interaction region. 30 - 32 – 290086/
14. The device according to claim 13, wherein each actuator of said plurality of actuators comprises an actuator elastic portion in communication with said actuator activable portion, the actuator elastic portion being operable to return the actuator activable portion from said second activated spatial configuration into said first resting spatial configuration once the actuator activable portion is no more activated by said remote energy source.
15. The device according to claim 14, wherein said actuator elastic portion is operable to engage with the associated interaction region, when said actuator activable portion is activated by said remote energy source, to cause the IOL to rotate with the incremental rotation.
16. The device according to any one of claims 13 to 15, wherein said actuator activable portion comprises a shape-memory material operable to provide said first resting spatial configuration and second activated spatial configuration.
17. The device according to claim 16, wherein said shape-memory material comprises nitinol.
18. The device according to any one of the preceding claims, wherein said stator portion comprises super-elastic material.
19. The device according to any one of the preceding claims, wherein said rotor portion comprises super-elastic material.
20. The device according to claim 18 or 19, wherein said super-elastic material comprises nitinol.
21. The device according to any one of the claims 18 to 20, wherein said device is foldable such that it can be passed through a cross-section of 2.54mm or 1.8mm circular diameter.
22. The device according to any one of the preceding claims, wherein said incremental rotation has an angular distance being equivalent to or greater than an angle of 0.3º.
23. The device according to any one of the preceding claims, wherein one or more of said at least one interaction region is(are) defined by a series of teeth protrusions. - 33 – 290086/
24. The device according to claim 23, wherein each tooth protrusion defines an incremental rotation of angular distance being equivalent to or greater than an angle of 0.6º.
25. The device according to any one of the preceding claims, comprising one or more marks enabling to identify each actuator of the plurality of actuators to thereby enable which actuator is to be activated.
26. An IOL adjustment system comprising: - the device of any one of the claims 1 to 25; and - a remote energy source configured and operable to provide said energy to said plurality of actuators.
27. The system according to claim 26, wherein said remote energy source is configured and operable to provide said energy in the form of heat.
28. The system according to claim 27, wherein said remote energy source comprises a radiating element.
29. The system according to claim 27, wherein said remote energy source comprises a laser source.
30. The system according to claim 29, wherein said laser source is configured and operable to provide continuous laser radiation.
31. The system according to claim 30, wherein said laser source is configured as an Argon laser source operable to provide light of a green spectrum.
32. The system according to any one of the claims 29 to 31, wherein said laser source is configured and operable to provide laser power between 0.1 – 5 watt, and laser pulse width between 200-1000ms.
33. The system according to claim 26, wherein said remote energy source comprises an electromagnetic radiation transmitter and said plurality of actuators comprise corresponding electromagnetic radiation receivers.
IL290086A 2022-01-24 2022-01-24 Intraocular lens holding devices IL290086B2 (en)

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IL290086A IL290086B2 (en) 2022-01-24 2022-01-24 Intraocular lens holding devices
PCT/IL2023/050075 WO2023139589A1 (en) 2022-01-24 2023-01-23 Intraocular lens holding devices

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IL290086A IL290086B2 (en) 2022-01-24 2022-01-24 Intraocular lens holding devices

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IL290086B2 true IL290086B2 (en) 2023-04-01

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US20110040378A1 (en) * 2007-01-29 2011-02-17 Werblin Research & Development Corp. Intraocular lens system
WO2014197170A1 (en) * 2013-06-03 2014-12-11 Clarvista Medical, Inc. Modular intraocular lens designs and methods
US20170296331A1 (en) * 2015-01-06 2017-10-19 Infinitevision Optics Multicomponent intraocular lens
US20180271645A1 (en) * 2015-12-01 2018-09-27 Lensgen, Inc. Accommodating intraocular lens device
US20200197157A1 (en) * 2017-06-13 2020-06-25 Eyemed Technologies Ltd Intraocular lens system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110040378A1 (en) * 2007-01-29 2011-02-17 Werblin Research & Development Corp. Intraocular lens system
WO2014197170A1 (en) * 2013-06-03 2014-12-11 Clarvista Medical, Inc. Modular intraocular lens designs and methods
US20170296331A1 (en) * 2015-01-06 2017-10-19 Infinitevision Optics Multicomponent intraocular lens
US20180271645A1 (en) * 2015-12-01 2018-09-27 Lensgen, Inc. Accommodating intraocular lens device
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