US20200359956A1 - Real-time parathyroid sensing system - Google Patents
Real-time parathyroid sensing system Download PDFInfo
- Publication number
- US20200359956A1 US20200359956A1 US16/764,488 US201816764488A US2020359956A1 US 20200359956 A1 US20200359956 A1 US 20200359956A1 US 201816764488 A US201816764488 A US 201816764488A US 2020359956 A1 US2020359956 A1 US 2020359956A1
- Authority
- US
- United States
- Prior art keywords
- parathyroid
- sensing system
- autofluorescence
- light source
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4227—Evaluating particular parts, e.g. particular organs endocrine glands, i.e. thyroid, adrenals, hypothalamic, pituitary
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7228—Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
Definitions
- the present invention relates to a real-time parathyroid sensing system, and more particularly, to a sensing system that may determine a location of parathyroid by sensing autofluorescence of the parathyroid.
- parathyroid In thyroid dissection for removing thyroid tumors, it is very important to preserve parathyroid for maintaining calcium homeostasis of our body. Since the parathyroid is a very small and delicate organ having a weight of 35 to 45 mg and a size of approximately 5 ⁇ 3 ⁇ 1 mm, it is not easy to distinguish the parathyroid from surrounding tissues such as the thyroid and a lymph gland with the naked eyes.
- FIG. 1( a ) illustrates a location of parathyroid and FIG. 1( b ) illustrates lymph node subgroups of the neck separated into levels relevant for surgical dissections.
- the parathyroid is positioned at a rear side of thyroid positioned at the center of a front of a neck.
- lymph glands (level VI) surrounding thyroid are dissected together by considering a metastasis possibility at the time of thyroid tumor dissection. This is referred to as central compartment neck dissection (CCND).
- CCND central compartment neck dissection
- Dividing the lymph gland into the subgroups according the location is referred to as a level system.
- the level system is classified into a total of 7 levels. It is characterized in that among 7 levels, the thyroid is present in section level VI and papillary thyroid carcinoma primarily spreads well to lymph gland level VI.
- a medical device has been commercialized, which allows the surgeon to determine the location of a nerve by using electrical conduction of the nerve in order to preserve a vocal nerve at the time of surgery of the thyroid tumors, but development of a device which can minutely determine the location of the parathyroid is insufficient.
- An object of the present invention is to provide a sensing system that sounds an alarm when a probe or a surgical instrument accesses parathyroid by using a point that the parathyroid emits stronger autofluorescence than thyroid and surrounding tissues.
- a parathyroid sensing system includes: a modulator for generating a modulation signal having a predetermined frequency; a lock-in amplifier and a light source which receive information on the modulation signal; an excitation filter for transmitting, among light emitted from the light source, only excitation light that excites parathyroid glands; an emission filter connected to a probe and selectively transmitting only autofluorescence emitting from the parathyroid glands; a near-infrared sensor for sensing the autofluorescence that has passed through the emission filter, and converting the sensed autofluorescence into an electric signal; and a speaker for generating an alarm through the electric signal.
- the light source includes a controller modulating an intensity of the light source based on the received modulation signal information.
- the near-infrared sensor is a photomultiplier tube (PMT) or avalanche photo diode (APD).
- PMT photomultiplier tube
- APD avalanche photo diode
- the lock-in amplifier receives the electric signal from the near-infrared sensor and generates a signal without noise based on the modulation signal information received from the modulator.
- the parathyroid sensing system further includes a micro-controller converting the electric signal into an electric signal which may be recognized by the speaker.
- the emission filter is connected to a first optical fiber and the excitation filter is connected to a second optical fiber and both are integrated in one probe.
- a location of parathyroid can be precisely determined even while an operating room is lighted.
- the locations of the parathyroid glands can be precisely detected, even when the probe is not directly in contact with the parathyroid glands, by using the autofluorescence characteristics of the parathyroid glands.
- FIG. 1( a ) illustrates a location of parathyroid and FIG. 1( b ) illustrates subgroups of lymph nodes.
- FIG. 2 illustrates a parathyroid sensing system according to an embodiment of the present invention.
- FIG. 3 illustrates a parathyroid sensing system according to another embodiment of the present invention.
- FIG. 4 is a photograph of sensing parathyroid by using a parathyroid sensing system according to the present invention.
- FIG. 5 illustrates observation of a waveform changed by applying a parathyroid sensing system according to the present invention to a part considered as a place where parathyroid is positioned.
- FIG. 6( a ) is a graph showing an intensity depending on a time when applying wavelength filtering
- FIG. 6( b ) is a graph showing an intensity depending on the time when applying frequency filtering in addition to the wavelength filtering.
- FIG. 2 is a diagram illustrating a parathyroid sensing system according to an embodiment of the present invention.
- a surgeon first dissects only skin and then images an entire surgical field and the location of the parathyroid in a context thereof and roughly determines the entire surgical field and the location of the parathyroid. Thereafter, thyroid tumors and lymph glands are removed and here, when the location of the parathyroid is determined, a very thin probe which is as large as the size of the parathyroid is used.
- the present invention relates to a parathyroid sensing system that sounds an alarm in real time when a surgeon approaches a probe or surgical instrument near the parathyroid gland during surgery.
- the parathyroid has a particular excitation spectrum and a particular emission spectrum
- an excitation filter and an emission filter should be used.
- the parathyroid sensing system includes: a modulator 100 for generating a modulation signal having a predetermined frequency; a lock-in amplifier 200 and a light source 300 which receive information on the modulation signal; and excitation filter 400 for transmitting, among light emitted from the light source, only excitation light that excites the parathyroid glands; a probe 500 and an emission filter 600 connected to the probe 500 and selectively transmitting only autofluorescence emitted from the parathyroid glands; a near-infrared sensor 700 for sensing the autofluorescence that has passed through the emission filter 600 , and converting the sensed autofluorescence into an electric signal; and a speaker 900 for generating an alarm through the electric signal.
- the parathyroid sensing system may further include a micro-controller 800 which converts the electric signal into an electric signal which may be recognized by the speaker.
- a heterodyne detection technique is introduced so that parathyroid autofluorescence may be more clearly sensed even in a noise environment such as operating room lighting and electric noise.
- a noise environment such as operating room lighting and electric noise.
- very weak parathyroid autofluorescence may be detected even in a situation in which a fluorescent lamp and a surgical light are turned on during surgery. A process of sensing parathyroid by performing heterodyne detection will be described below.
- an intensity of a light source is modulated by inputting the modulation signal into a controller of the light source (S 100 A).
- the modulation signal is input into a reference unit of the lock-in amplifier 200 to separate an autofluorescence signal modulated later from a noise environment (S 100 B).
- an optical fiber When parathyroid autofluorescence is detected by a probe having a very small diameter, an optical fiber is primarily used and since the optical fiber has a unique numerical aperture (NA) (in general, 0.22), only light having a particular angle may be captured. Accordingly, since an amount of light which may be captured is very small, a high-sensitivity near-infrared sensor should be provided in order to detect autofluorescence which is inherently weak in light intensity.
- a photomultiplier tube (PMT) is used as the high-sensitivity near-infrared sensor 700 , but an avalanche photo diode (APD) may also be used. Meanwhile, when a high-sensitivity PMT is used, an exposure time is very short, and as a result, it is possible to sense the parathyroid autofluorescence in real time.
- Noise from other lights in the operating room is mixed in the modulated light signal and electric noise is also added via the near-infrared sensor 700 .
- the lock-in amplifier 200 inputs a signal without noise into the micro-controller 800 based on modulation signal information (frequency) of the reference unit previously input from the modulator 100 (S 500 ).
- the micro-controller 800 converts the signal into the electric signal which may be recognized by the speaker 900 to allow the speaker 900 to generate an alarm sound (S 600 ).
- the micro-controller 800 may inform whether the parathyroid is detected with a numerical value, a graph, or a color change through a provided output device.
- FIG. 2 is a diagram illustrating a parathyroid sensing system according to an embodiment of the present invention.
- a surgeon first dissects only skin and then images an entire surgical field and the location of the parathyroid in a context thereof and roughly determines the entire surgical field and the location of the parathyroid. Thereafter, thyroid tumors and lymph glands are removed and here, when the location of the parathyroid is determined, a very thin probe which is as large as the size of the parathyroid is used.
- the present invention relates to a parathyroid sensing system that sounds an alarm in real time when a surgeon approaches a probe or surgical instrument near the parathyroid gland during surgery.
- the parathyroid has a particular excitation spectrum and a particular emission spectrum
- an excitation filter and an emission filter should be used.
- the parathyroid sensing system includes: a modulator 100 for generating a modulation signal having a predetermined frequency; a lock-in amplifier 200 and a light source 300 which receive information on the modulation signal; and excitation filter 400 for transmitting, among light emitted from the light source, only excitation light that excites the parathyroid glands; a probe 500 and an emission filter 600 connected to the probe 500 and selectively transmitting only autofluorescence emitted from the parathyroid glands; a near-infrared sensor 700 for sensing the autofluorescence that has passed through the emission filter 600 , and converting the sensed autofluorescence into an electric signal; and a speaker 900 for generating an alarm through the electric signal.
- the parathyroid sensing system may further include a micro-controller 800 which converts the electric signal into an electric signal which may be recognized by the speaker.
- a heterodyne detection technique is introduced so that parathyroid autofluorescence may be more clearly sensed even in a noise environment such as operating room lighting, electric noise, etc.
- a noise environment such as operating room lighting, electric noise, etc.
- very weak parathyroid autofluorescence may be detected even in a situation in which a fluorescent lamp and a surgical light are turned on during surgery. A process of sensing parathyroid by performing heterodyne detection will be described below.
- an intensity of a light source is modulated by inputting the modulation signal into a controller of the light source (S 100 A).
- the modulation signal is input into a reference unit of the lock-in amplifier 200 to separate an autofluorescence signal modulated later from a noise environment (S 100 B).
- an optical fiber When parathyroid autofluorescence is detected by a probe having a very small diameter, an optical fiber is primarily used and since the optical fiber has a unique numerical aperture (NA) (in general, 0 . 22 ), only light having a particular angle may be captured. Accordingly, since an amount of light which may be captured is very small, a high-sensitivity near-infrared sensor should be provided in order to detect autofluorescence which is inherently weak in light intensity.
- a photomultiplier tube (PMT) is used as the high-sensitivity near-infrared sensor 700 , but an avalanche photo diode (APD) may also be used. Meanwhile, when a high-sensitivity PMT is used, an exposure time is very short, and as a result, it is possible to sense the parathyroid autofluorescence in real time.
- Noise from other lights in the operating room is mixed in the modulated light signal and electric noise is also added via the near-infrared sensor 700 .
- the lock-in amplifier 200 inputs a signal without noise into the micro-controller 800 based on modulation signal information (frequency) of the reference unit previously input from the modulator 100 (S 500 ).
- the micro-controller 800 converts the signal into the electric signal which may be recognized by the speaker 900 to allow the speaker 900 to generate an alarm sound (S 600 ).
- the micro-controller 800 may inform whether the parathyroid is detected with a numerical value, a graph, or a color change through a provided output device.
- FIG. 3 illustrates a parathyroid sensing system according to another embodiment of the present invention.
- FIG. 2 illustrates a structure in which the probe and a light source (excitation) are separated, but the embodiment illustrated in FIG. 3 has a structure in which the emission filter 600 is connected to a first optical fiber and the excitation filter 400 is connected to a second optical fiber and both are integrated in one probe.
- excitation light may be illuminated to a wide area as parallel light, an influence may be removed, in which the intensity of the autofluorescence is changed while the intensity of the excitation light varies depending on a distance between the light source and the parathyroid. In this case, a signal is detected in inverse proportion only to the square of the distance between the probe and the parathyroid gland.
- FIG. 3 illustrates a structure in which the excitation light and emission light travel in opposite directions within one probe 500 .
- the excitation light may be strongly focused and sent to the probe 500 .
- the probe 500 supplies the excitation light to the parathyroid and also receives the autofluorescence which is emitted, the excitation is illuminated in inverse proportion to the square of the distance and the intensity of the light detected is also in inverse proportion to the square of the distance. Accordingly, when the distance between the probe 500 and the parathyroid decreases, a detected signal rapidly increases.
- the surgeon should additionally hold an excitation illumination in addition to the probe held in a hand thereof or fix the excitation illumination to the top of a surgical field, but in the parathyroid sensing system illustrated in FIG. 3 , since the excitation illumination (light source) is included in the probe 500 , a case where the illumination is obscured by other structures, the light is misdirected to areas other than a parathyroid portion, or both hands of the surgeon should be used may be excluded.
- the excitation illumination light source
- an optical fiber sending the light and an optical fiber receiving the light may be separated from the beginning by using two or more optical fiber bundles, but a 2 x 1 beam splitter, an optical circulator, and/or a double cladding fiber which sends and receives the light in each of core and cladding modes may be used, in order to use only one optical fiber.
- FIG. 4 is a photograph of sensing parathyroid by using a parathyroid sensing system according to the present invention and FIG. 5 illustrates observation of a waveform changed by applying a parathyroid sensing system according to the present invention to a part considered as a place where parathyroid is positioned.
- FIG. 4 is a photograph of an experiment by the parathyroid sensing system illustrated in FIG. 2
- FIG. 5 is a photograph of an experiment by the parathyroid sensing system illustrated in FIG. 3 .
- FIGS. 5( a ) and 5( b ) when the probe approaches a portion where the parathyroid is positioned ( FIG. 5( b ) ), it can be seen that a waveform is rapidly changed, compared to that before ( FIG. 5( a ) ).
- the corresponding locations may be precisely detected, even when the probe is not directly in contact with the parathyroid glands, by using the autofluorescence characteristics of the parathyroid glands.
- FIG. 6( a ) is a graph showing an intensity depending on a time when applying wavelength filtering using an optical filter
- FIG. 6( b ) is a graph showing an intensity depending on the time when applying frequency filtering using modulation in addition to the wavelength filtering.
- the frequency filtering is additionally performed in order to use the heterodyne detection technique ( FIG. 6( b ) ).
- the autofluorescence may be selectively measured even in an optical and/or electric noise environment. This means that the autofluorescence exciting the parathyroid is more clearly detected.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Physiology (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Psychiatry (AREA)
- Signal Processing (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
- This application is the national stage of International Patent Cooperation Treaty Application PCT/KR2018/013286 filed 5 Nov. 2018, which claims priority from Korean Patent Application No. 10-2017-0154274 filed 17 Nov. 2017, in the Korean Intellectual Property Office. The entire contents of said applications are incorporated herein by reference for all purposes.
- The present invention relates to a real-time parathyroid sensing system, and more particularly, to a sensing system that may determine a location of parathyroid by sensing autofluorescence of the parathyroid.
- In thyroid dissection for removing thyroid tumors, it is very important to preserve parathyroid for maintaining calcium homeostasis of our body. Since the parathyroid is a very small and delicate organ having a weight of 35 to 45 mg and a size of approximately 5×3×1 mm, it is not easy to distinguish the parathyroid from surrounding tissues such as the thyroid and a lymph gland with the naked eyes.
-
FIG. 1(a) illustrates a location of parathyroid andFIG. 1(b) illustrates lymph node subgroups of the neck separated into levels relevant for surgical dissections. - Referring to
FIG. 1(a) , it can be seen that the parathyroid is positioned at a rear side of thyroid positioned at the center of a front of a neck. There are generally a total of 4 parathyroids, and one is positioned at each of left upper and lower portions and one is positioned at each of right upper and lower portions. - As indicated in
FIG. 1(b) illustrating the subgroups of the lymph gland, lymph glands (level VI) surrounding thyroid are dissected together by considering a metastasis possibility at the time of thyroid tumor dissection. This is referred to as central compartment neck dissection (CCND). Dividing the lymph gland into the subgroups according the location is referred to as a level system. The level system is classified into a total of 7 levels. It is characterized in that among 7 levels, the thyroid is present in section level VI and papillary thyroid carcinoma primarily spreads well to lymph gland level VI. - At the time of performing the central compartment neck dissection, since a normal lymph gland is very small, it is almost impossible to identify the normal lymph gland with the naked eyes. Accordingly, both a fatty tissue and a connective tissue including the lymph gland are removed at the time of dissecting the lymph gland.
- Here, it becomes important to determine the location of the parathyroid. The reason is that it is not easy to distinguish the parathyroid from the surrounding fatty tissue or connective tissue in section level VI unless a person is a skilled surgeon.
- At present, a medical device has been commercialized, which allows the surgeon to determine the location of a nerve by using electrical conduction of the nerve in order to preserve a vocal nerve at the time of surgery of the thyroid tumors, but development of a device which can minutely determine the location of the parathyroid is insufficient.
- An object of the present invention is to provide a sensing system that sounds an alarm when a probe or a surgical instrument accesses parathyroid by using a point that the parathyroid emits stronger autofluorescence than thyroid and surrounding tissues.
- In order to solve the technical problem, a parathyroid sensing system according to the present invention includes: a modulator for generating a modulation signal having a predetermined frequency; a lock-in amplifier and a light source which receive information on the modulation signal; an excitation filter for transmitting, among light emitted from the light source, only excitation light that excites parathyroid glands; an emission filter connected to a probe and selectively transmitting only autofluorescence emitting from the parathyroid glands; a near-infrared sensor for sensing the autofluorescence that has passed through the emission filter, and converting the sensed autofluorescence into an electric signal; and a speaker for generating an alarm through the electric signal.
- In addition, the light source includes a controller modulating an intensity of the light source based on the received modulation signal information.
- In addition, the near-infrared sensor is a photomultiplier tube (PMT) or avalanche photo diode (APD).
- Further, the lock-in amplifier receives the electric signal from the near-infrared sensor and generates a signal without noise based on the modulation signal information received from the modulator.
- Further, the parathyroid sensing system further includes a micro-controller converting the electric signal into an electric signal which may be recognized by the speaker.
- Further, the emission filter is connected to a first optical fiber and the excitation filter is connected to a second optical fiber and both are integrated in one probe.
- Effects of a real-time parathyroid sensing system according to embodiments of the present invention will be described below.
- Through the present invention, a location of parathyroid can be precisely determined even while an operating room is lighted.
- Further, the locations of the parathyroid glands can be precisely detected, even when the probe is not directly in contact with the parathyroid glands, by using the autofluorescence characteristics of the parathyroid glands.
- Further, convenience can be provided by alerting a surgeon by means of an alarm when the parathyroid glands are detected.
- However, effects obtainable by a real-time parathyroid sensing system according to embodiments of the present invention are not limited to the aforementioned effects and other unmentioned effects will be clearly understood by those skilled in the art from the following description.
- In order to help understand the present invention, the accompanying drawings which are included as a part of the Detailed Description provide embodiments of the present invention and describe the technical spirit of the present invention together with the Detailed Description.
-
FIG. 1(a) illustrates a location of parathyroid andFIG. 1(b) illustrates subgroups of lymph nodes. -
FIG. 2 illustrates a parathyroid sensing system according to an embodiment of the present invention. -
FIG. 3 illustrates a parathyroid sensing system according to another embodiment of the present invention. -
FIG. 4 is a photograph of sensing parathyroid by using a parathyroid sensing system according to the present invention. -
FIG. 5 illustrates observation of a waveform changed by applying a parathyroid sensing system according to the present invention to a part considered as a place where parathyroid is positioned. -
FIG. 6(a) is a graph showing an intensity depending on a time when applying wavelength filtering, andFIG. 6(b) is a graph showing an intensity depending on the time when applying frequency filtering in addition to the wavelength filtering. - Best Mode
-
FIG. 2 is a diagram illustrating a parathyroid sensing system according to an embodiment of the present invention. - During thyroid surgery, a surgeon first dissects only skin and then images an entire surgical field and the location of the parathyroid in a context thereof and roughly determines the entire surgical field and the location of the parathyroid. Thereafter, thyroid tumors and lymph glands are removed and here, when the location of the parathyroid is determined, a very thin probe which is as large as the size of the parathyroid is used.
- The present invention relates to a parathyroid sensing system that sounds an alarm in real time when a surgeon approaches a probe or surgical instrument near the parathyroid gland during surgery.
- Since the parathyroid has a particular excitation spectrum and a particular emission spectrum, there should be a light source and a sensing system suitable therefor. In this case, since the excitation spectrum and the emission spectrum generally overlap with each other, an excitation filter and an emission filter should be used.
- The parathyroid sensing system according to the present invention includes: a
modulator 100 for generating a modulation signal having a predetermined frequency; a lock-inamplifier 200 and alight source 300 which receive information on the modulation signal; andexcitation filter 400 for transmitting, among light emitted from the light source, only excitation light that excites the parathyroid glands; aprobe 500 and anemission filter 600 connected to theprobe 500 and selectively transmitting only autofluorescence emitted from the parathyroid glands; a near-infrared sensor 700 for sensing the autofluorescence that has passed through theemission filter 600, and converting the sensed autofluorescence into an electric signal; and aspeaker 900 for generating an alarm through the electric signal. Further, the parathyroid sensing system may further include a micro-controller 800 which converts the electric signal into an electric signal which may be recognized by the speaker. - In the present invention, a heterodyne detection technique is introduced so that parathyroid autofluorescence may be more clearly sensed even in a noise environment such as operating room lighting and electric noise. When the heterodyne detection technique is used, very weak parathyroid autofluorescence may be detected even in a situation in which a fluorescent lamp and a surgical light are turned on during surgery. A process of sensing parathyroid by performing heterodyne detection will be described below.
- After a modulation signal at a specific frequency is generated by using the
modulator 100, an intensity of a light source is modulated by inputting the modulation signal into a controller of the light source (S100A). - Further, the modulation signal is input into a reference unit of the lock-in
amplifier 200 to separate an autofluorescence signal modulated later from a noise environment (S100B). - When the parathyroid is excited through the near-
infrared light source 300, autofluorescence modulated at the same frequency is generated in the parathyroid by the modulated light source (S200) and a light signal is sensed by the near-infrared sensor 700 via theemission filter 600 and converted into the electric signal (S300). - When parathyroid autofluorescence is detected by a probe having a very small diameter, an optical fiber is primarily used and since the optical fiber has a unique numerical aperture (NA) (in general, 0.22), only light having a particular angle may be captured. Accordingly, since an amount of light which may be captured is very small, a high-sensitivity near-infrared sensor should be provided in order to detect autofluorescence which is inherently weak in light intensity. In the present invention, a photomultiplier tube (PMT) is used as the high-sensitivity near-
infrared sensor 700, but an avalanche photo diode (APD) may also be used. Meanwhile, when a high-sensitivity PMT is used, an exposure time is very short, and as a result, it is possible to sense the parathyroid autofluorescence in real time. - Noise from other lights in the operating room is mixed in the modulated light signal and electric noise is also added via the near-
infrared sensor 700. When voltage output from the near-infrared sensor 700 is input into an input unit of the lock-in amplifier 200 (S400), the lock-inamplifier 200 inputs a signal without noise into themicro-controller 800 based on modulation signal information (frequency) of the reference unit previously input from the modulator 100 (S500). Themicro-controller 800 converts the signal into the electric signal which may be recognized by thespeaker 900 to allow thespeaker 900 to generate an alarm sound (S600). Themicro-controller 800 may inform whether the parathyroid is detected with a numerical value, a graph, or a color change through a provided output device. - Terms or words used in the present specification and claims should not be interpreted as being limited to typical or dictionary meanings, but should be interpreted as having meanings and concepts which comply with the technical spirit of the present disclosure, based on the principle that an inventor can appropriately define the concept of the term to describe his/her own invention in the best manner. Accordingly, configurations illustrated in the exemplary embodiments and drawings disclosed in the present specification are only the most preferred embodiment of the present invention and do not represent all of the technical spirit of the present invention, and thus it is to be understood that various equivalents and modified examples, which may replace the configurations, are possible when filing the present application. Hereinafter, a real-time parathyroid sensing system according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings.
-
FIG. 2 is a diagram illustrating a parathyroid sensing system according to an embodiment of the present invention. - During thyroid surgery, a surgeon first dissects only skin and then images an entire surgical field and the location of the parathyroid in a context thereof and roughly determines the entire surgical field and the location of the parathyroid. Thereafter, thyroid tumors and lymph glands are removed and here, when the location of the parathyroid is determined, a very thin probe which is as large as the size of the parathyroid is used.
- The present invention relates to a parathyroid sensing system that sounds an alarm in real time when a surgeon approaches a probe or surgical instrument near the parathyroid gland during surgery.
- Since the parathyroid has a particular excitation spectrum and a particular emission spectrum, there should be a light source and a sensing system suitable therefor. In this case, since the excitation spectrum and the emission spectrum generally overlap with each other, an excitation filter and an emission filter should be used.
- The parathyroid sensing system according to the present invention includes: a
modulator 100 for generating a modulation signal having a predetermined frequency; a lock-inamplifier 200 and alight source 300 which receive information on the modulation signal; andexcitation filter 400 for transmitting, among light emitted from the light source, only excitation light that excites the parathyroid glands; aprobe 500 and anemission filter 600 connected to theprobe 500 and selectively transmitting only autofluorescence emitted from the parathyroid glands; a near-infrared sensor 700 for sensing the autofluorescence that has passed through theemission filter 600, and converting the sensed autofluorescence into an electric signal; and aspeaker 900 for generating an alarm through the electric signal. Further, the parathyroid sensing system may further include amicro-controller 800 which converts the electric signal into an electric signal which may be recognized by the speaker. - In the present invention, a heterodyne detection technique is introduced so that parathyroid autofluorescence may be more clearly sensed even in a noise environment such as operating room lighting, electric noise, etc. When the heterodyne detection technique is used, very weak parathyroid autofluorescence may be detected even in a situation in which a fluorescent lamp and a surgical light are turned on during surgery. A process of sensing parathyroid by performing heterodyne detection will be described below.
- After a modulation signal at a specific frequency is generated by using the
modulator 100, an intensity of a light source is modulated by inputting the modulation signal into a controller of the light source (S100A). - Further, the modulation signal is input into a reference unit of the lock-in
amplifier 200 to separate an autofluorescence signal modulated later from a noise environment (S100B). - When the parathyroid is excited through the near-infrared
light source 300, autofluorescence modulated at the same frequency is generated in the parathyroid by the modulated light source (S200) and a light signal is sensed by the near-infrared sensor 700 via theemission filter 600 and converted into the electric signal (S300). - When parathyroid autofluorescence is detected by a probe having a very small diameter, an optical fiber is primarily used and since the optical fiber has a unique numerical aperture (NA) (in general, 0.22), only light having a particular angle may be captured. Accordingly, since an amount of light which may be captured is very small, a high-sensitivity near-infrared sensor should be provided in order to detect autofluorescence which is inherently weak in light intensity. In the present invention, a photomultiplier tube (PMT) is used as the high-sensitivity near-
infrared sensor 700, but an avalanche photo diode (APD) may also be used. Meanwhile, when a high-sensitivity PMT is used, an exposure time is very short, and as a result, it is possible to sense the parathyroid autofluorescence in real time. - Noise from other lights in the operating room is mixed in the modulated light signal and electric noise is also added via the near-
infrared sensor 700. When voltage output from the near-infrared sensor 700 is input into an input unit of the lock-in amplifier 200 (S400), the lock-inamplifier 200 inputs a signal without noise into themicro-controller 800 based on modulation signal information (frequency) of the reference unit previously input from the modulator 100 (S500). Themicro-controller 800 converts the signal into the electric signal which may be recognized by thespeaker 900 to allow thespeaker 900 to generate an alarm sound (S600). Themicro-controller 800 may inform whether the parathyroid is detected with a numerical value, a graph, or a color change through a provided output device. -
FIG. 3 illustrates a parathyroid sensing system according to another embodiment of the present invention. -
FIG. 2 illustrates a structure in which the probe and a light source (excitation) are separated, but the embodiment illustrated inFIG. 3 has a structure in which theemission filter 600 is connected to a first optical fiber and theexcitation filter 400 is connected to a second optical fiber and both are integrated in one probe. - In the structure illustrated in
FIG. 2 , since excitation light may be illuminated to a wide area as parallel light, an influence may be removed, in which the intensity of the autofluorescence is changed while the intensity of the excitation light varies depending on a distance between the light source and the parathyroid. In this case, a signal is detected in inverse proportion only to the square of the distance between the probe and the parathyroid gland. - On the contrary,
FIG. 3 illustrates a structure in which the excitation light and emission light travel in opposite directions within oneprobe 500. In the structure, there is an advantage in that the excitation light may be strongly focused and sent to theprobe 500. Further, since theprobe 500 supplies the excitation light to the parathyroid and also receives the autofluorescence which is emitted, the excitation is illuminated in inverse proportion to the square of the distance and the intensity of the light detected is also in inverse proportion to the square of the distance. Accordingly, when the distance between theprobe 500 and the parathyroid decreases, a detected signal rapidly increases. - In the parathyroid sensing system illustrated in
FIG. 2 , the surgeon should additionally hold an excitation illumination in addition to the probe held in a hand thereof or fix the excitation illumination to the top of a surgical field, but in the parathyroid sensing system illustrated inFIG. 3 , since the excitation illumination (light source) is included in theprobe 500, a case where the illumination is obscured by other structures, the light is misdirected to areas other than a parathyroid portion, or both hands of the surgeon should be used may be excluded. - Meanwhile, as illustrated in
FIG. 3 , an optical fiber sending the light and an optical fiber receiving the light may be separated from the beginning by using two or more optical fiber bundles, but a 2 x 1 beam splitter, an optical circulator, and/or a double cladding fiber which sends and receives the light in each of core and cladding modes may be used, in order to use only one optical fiber. -
FIG. 4 is a photograph of sensing parathyroid by using a parathyroid sensing system according to the present invention andFIG. 5 illustrates observation of a waveform changed by applying a parathyroid sensing system according to the present invention to a part considered as a place where parathyroid is positioned. -
FIG. 4 is a photograph of an experiment by the parathyroid sensing system illustrated inFIG. 2 , andFIG. 5 is a photograph of an experiment by the parathyroid sensing system illustrated inFIG. 3 . Referring toFIGS. 5(a) and 5(b) , when the probe approaches a portion where the parathyroid is positioned (FIG. 5(b) ), it can be seen that a waveform is rapidly changed, compared to that before (FIG. 5(a) ). In the present invention, the corresponding locations may be precisely detected, even when the probe is not directly in contact with the parathyroid glands, by using the autofluorescence characteristics of the parathyroid glands. -
FIG. 6(a) is a graph showing an intensity depending on a time when applying wavelength filtering using an optical filter andFIG. 6(b) is a graph showing an intensity depending on the time when applying frequency filtering using modulation in addition to the wavelength filtering. - Compared to performing only the wavelength filtering of dividing the channel (
FIG. 6(a) ), in the present invention, the frequency filtering is additionally performed in order to use the heterodyne detection technique (FIG. 6(b) ). In this case, it can be seen that only the autofluorescence may be selectively measured even in an optical and/or electric noise environment. This means that the autofluorescence exciting the parathyroid is more clearly detected. - Although representative exemplary embodiments of the present invention have been described in detail hereinabove, it will be appreciated by those skilled in the art that various modifications of the exemplary embodiment of the present invention can be made within a limit without departing from the scope of the present invention. Therefore, the scope of the present invention should not be limited to the embodiments and should be defined by the appended claims and equivalents to the appended claims.
Claims (6)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020170154274A KR101852403B1 (en) | 2017-11-17 | 2017-11-17 | Parathyroid real-time sensing system |
KR10-2017-0154274 | 2017-11-17 | ||
PCT/KR2018/013286 WO2019098580A1 (en) | 2017-11-17 | 2018-11-05 | Real-time parathyroid sensing system |
Publications (2)
Publication Number | Publication Date |
---|---|
US20200359956A1 true US20200359956A1 (en) | 2020-11-19 |
US11559248B2 US11559248B2 (en) | 2023-01-24 |
Family
ID=62081655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/764,488 Active 2039-10-15 US11559248B2 (en) | 2017-11-17 | 2018-11-05 | Real-time parathyroid sensing system |
Country Status (5)
Country | Link |
---|---|
US (1) | US11559248B2 (en) |
EP (1) | EP3711655B1 (en) |
KR (1) | KR101852403B1 (en) |
CN (1) | CN111343910B (en) |
WO (1) | WO2019098580A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114711727A (en) * | 2022-05-09 | 2022-07-08 | 江苏百宁盈创医疗科技有限公司 | Novel parathyroid gland detecting device |
CN116385337A (en) * | 2022-12-15 | 2023-07-04 | 陕西中科创孚医疗科技有限责任公司 | Parathyroid gland recognition device and method based on multi-light fusion |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110215193B (en) * | 2019-07-08 | 2021-11-26 | 济南显微智能科技有限公司 | Parathyroid gland spontaneous fluorescence face imaging spectrometer capable of rapidly recognizing |
CN117838065A (en) * | 2024-03-07 | 2024-04-09 | 江苏百宁盈创医疗科技有限公司 | Method, device, apparatus and storage medium for detecting self-fluorescence tissue |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9687190B2 (en) * | 2008-07-30 | 2017-06-27 | Vanderbilt University | Intra-operative use of fluorescence spectroscopy and applications of same |
KR101166556B1 (en) * | 2010-12-07 | 2012-07-19 | 국립암센터 | Fluorescence sensing probe and fluorescence sensing method using the same |
JP2015523102A (en) | 2012-04-16 | 2015-08-13 | チルドレンズ ナショナル メディカル センターChildren’S National Medical Center | Dual-mode stereo imaging system for tracking and control in surgical and interventional procedures |
WO2013180127A1 (en) * | 2012-06-01 | 2013-12-05 | 国立大学法人高知大学 | Medical product that emits near-infrared fluorescence and medical-product usage-status ascertainment device |
KR101518110B1 (en) * | 2013-02-13 | 2015-05-06 | 충남대학교산학협력단 | Near-infrared Fluorescent Imaging Instrument for Surgical Guidance of Large Animal And Method for Imaging And Surgical Guidance thereof |
EP2983579A2 (en) | 2013-04-12 | 2016-02-17 | NinePoint Medical, Inc. | Multiple aperture, multiple modal optical systems and methods |
CN106455979A (en) * | 2013-12-31 | 2017-02-22 | 纪念斯隆-凯特琳癌症中心 | Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time |
DE102014108424B3 (en) * | 2014-06-16 | 2015-06-11 | Johann Wolfgang Goethe-Universität | Non-invasive substance analysis |
US20160073949A1 (en) * | 2014-09-11 | 2016-03-17 | Duncan M. Grant | Neuropathic Assistive Device |
JP2016087062A (en) * | 2014-11-04 | 2016-05-23 | ローム株式会社 | Optical biological imaging system |
US10579891B2 (en) | 2015-08-10 | 2020-03-03 | AI Biomed Corp | Optical overlay device |
US10050405B2 (en) * | 2016-04-19 | 2018-08-14 | Lumentum Operations Llc | Wavelength locker using multiple feedback curves to wavelength lock a beam |
-
2017
- 2017-11-17 KR KR1020170154274A patent/KR101852403B1/en active IP Right Grant
-
2018
- 2018-11-05 EP EP18878491.2A patent/EP3711655B1/en active Active
- 2018-11-05 WO PCT/KR2018/013286 patent/WO2019098580A1/en unknown
- 2018-11-05 CN CN201880073766.9A patent/CN111343910B/en active Active
- 2018-11-05 US US16/764,488 patent/US11559248B2/en active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114711727A (en) * | 2022-05-09 | 2022-07-08 | 江苏百宁盈创医疗科技有限公司 | Novel parathyroid gland detecting device |
CN116385337A (en) * | 2022-12-15 | 2023-07-04 | 陕西中科创孚医疗科技有限责任公司 | Parathyroid gland recognition device and method based on multi-light fusion |
Also Published As
Publication number | Publication date |
---|---|
CN111343910B (en) | 2023-03-28 |
US11559248B2 (en) | 2023-01-24 |
WO2019098580A1 (en) | 2019-05-23 |
CN111343910A (en) | 2020-06-26 |
EP3711655B1 (en) | 2024-01-31 |
KR101852403B1 (en) | 2018-04-27 |
EP3711655A1 (en) | 2020-09-23 |
EP3711655A4 (en) | 2021-07-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11559248B2 (en) | Real-time parathyroid sensing system | |
JP4954699B2 (en) | Fluorescence endoscope system | |
AU2007253771B2 (en) | Devices and methods for fluorescent inspection and/or removal of material in a sample | |
US8227766B2 (en) | Hand-held probe for intra-operative detection of fluorescence labeled compounds and antibodies | |
KR101847435B1 (en) | Device for real-time imaging of parathyroid | |
WO2008081659A1 (en) | Endoscope system | |
JP6721644B2 (en) | System and method for fluorescence-based laser ablation | |
JP5276228B2 (en) | Optical measurement system, optical measurement apparatus, calibration member, and calibration method | |
JP6564402B2 (en) | Blood vessel recognition device | |
US20120296218A1 (en) | Fluorescence endoscope device | |
JP7368597B2 (en) | Endoscopic laser system with laser interlock | |
Zhu et al. | Non-invasive fluorescence imaging under ambient light conditions using a modulated ICCD and laser diode | |
DE602004006396D1 (en) | ANALYSIS OF A COMPOSITION WITH OBSERVATION | |
JPWO2017212617A1 (en) | Near-infrared imaging device and marker member for near-infrared imaging device | |
WO2017119340A1 (en) | Living body observation method and living body observation device | |
US20100185100A1 (en) | Identifying and localizing tissue using light analysis | |
Yamada et al. | Multiphoton microscopy applications in biology | |
CN213249797U (en) | Integrated portable in-situ visible biological target identification and positioning system | |
NL2025324B1 (en) | A Surgical Tool, System and Method for Tissue Characterisation | |
KR20170022571A (en) | Endoscopy apparatus for taking fluorescence image | |
CN117355250A (en) | Surgical fluorescent probe for tumor detection | |
DE50207703D1 (en) | Device for the diagnostic diagnosis of tissue | |
Han et al. | Epi-detected ratio of forward-propagating to back-propagating second harmonic signal | |
Xie et al. | Cancer diagnostics using fluorescence/reflectance spectroscopy with a fiber optic point probe and least-squares support vector machines | |
JP2002125913A (en) | Fluorescence detector |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY), KOREA, REPUBLIC OF Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:AHN, YEH-CHAN;REEL/FRAME:052671/0076 Effective date: 20200509 Owner name: PUKYONG NATIONAL UNIVERSITY INDUSTRYUNIVERSITY COOPERATION FOUNDATION, KOREA, REPUBLIC OF Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:AHN, YEH-CHAN;REEL/FRAME:052671/0076 Effective date: 20200509 Owner name: UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY), KOREA, REPUBLIC OF Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAE, SUNG CHUL;REEL/FRAME:052671/0264 Effective date: 20200511 Owner name: PUKYONG NATIONAL UNIVERSITY INDUSTRYUNIVERSITY COOPERATION FOUNDATION, KOREA, REPUBLIC OF Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAE, SUNG CHUL;REEL/FRAME:052671/0264 Effective date: 20200511 |
|
FEPP | Fee payment procedure |
Free format text: ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: BIG.); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
FEPP | Fee payment procedure |
Free format text: ENTITY STATUS SET TO SMALL (ORIGINAL EVENT CODE: SMAL); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: APPLICATION DISPATCHED FROM PREEXAM, NOT YET DOCKETED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: PUBLICATIONS -- ISSUE FEE PAYMENT RECEIVED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: PUBLICATIONS -- ISSUE FEE PAYMENT VERIFIED |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |