US20190099543A1 - Light irradiation device - Google Patents

Light irradiation device Download PDF

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Publication number
US20190099543A1
US20190099543A1 US16/086,989 US201716086989A US2019099543A1 US 20190099543 A1 US20190099543 A1 US 20190099543A1 US 201716086989 A US201716086989 A US 201716086989A US 2019099543 A1 US2019099543 A1 US 2019099543A1
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United States
Prior art keywords
blood
flow channel
light
axis direction
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US16/086,989
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English (en)
Inventor
Michihiro SASAKI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
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Terumo Corp
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Assigned to TERUMO KABUSHIKI KAISHA reassignment TERUMO KABUSHIKI KAISHA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SASAKI, MICHIHIRO
Publication of US20190099543A1 publication Critical patent/US20190099543A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0047—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
    • A61M2205/053—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy ultraviolet

Definitions

  • the present invention relates to a light irradiation device that irradiates blood or a blood component with light in order to inactivate a virus included in the blood or the blood component.
  • a process of inactivating a virus included in a blood product is performed on various blood products (whole blood, concentrated erythrocytes, platelets, and plasma) manufactured on the basis of blood sampled from a blood donor.
  • Patent Literature 1 discloses a light irradiation device that irradiates a blood bag containing blood with light.
  • Patent Literature 1 Japanese Patent No. 4154191
  • the virus is inactivated while stirring the blood in the blood bag to pass through a thin layer portion in the light irradiation device disclosed in Patent Literature 1 .
  • the time required to inactivate the virus included in the blood in the blood bag increases.
  • the present invention has been made to solve the above-described problems, and an object thereof is to provide a light irradiation device capable of causing blood coagulation to hardly occur and inactivating a virus included in blood or a blood component in a short time.
  • a light irradiation device including: a flow channel through which blood or a blood component flows; and an LED lamp which irradiates the blood or the blood component flowing through the flow channel with light so as to inactivate a virus included in the blood or the blood component.
  • a multilayer structure in which a plurality of the flow channels is arranged in parallel is formed.
  • the flow channels by forming the multilayer structure in which the plurality of flow channels is arranged in parallel.
  • the throughput of the blood or the blood component per unit time so that the processing performance to inactivate the virus included in the blood or the blood component is improved.
  • the blood or the blood component is irradiated with light while causing the blood or the blood component to flow through the flow channel so that blood coagulation hardly occurs. Therefore, the blood coagulation hardly occurs, and it is possible to inactivate the virus included in the blood or the blood component in a short time.
  • the multilayer structure be formed for each of a first direction orthogonal to an axial direction of the flow channel and a second direction orthogonal to the axial direction of the flow channel and the first direction.
  • the processing performance to inactivate viruses included in the blood or the blood component is further improved so that it is possible to inactivate the virus included in the blood or the blood component in a shorter time.
  • the LED lamp be arranged at positions on both sides with respect to the flow channel in the direction orthogonal to the axial direction of the flow channel.
  • the processing performance to inactivate the virus included in the blood or the blood component is improved.
  • a section of the flow channel perpendicular to the axial direction of the flow channel be formed in a flat shape, and that the LED lamp be arranged at a position on a side in a lateral direction of the flat shape with respect to the flow channel.
  • the light is easily transmitted into the blood or the blood component flowing through the flow channel.
  • the processing performance to inactivate the virus included in the blood or the blood component is improved.
  • a plurality of the LED lamps be arranged in the axial direction of the flow channel.
  • the flow channel be formed in a linear shape in the axial direction of the flow channel.
  • the blood or the blood component flowing through the flow channel hardly receives a flow channel resistance, and thus, it is possible to increase the throughput of the blood or the blood component per unit time.
  • the flow channel be formed in a curved shape in the axial direction of the flow channel.
  • the light be ultraviolet light.
  • the light irradiation device of the present invention it is possible to cause the blood coagulation to hardly occur and to inactivate the virus included in the blood or the blood component in a short time.
  • FIG. 1 is a configuration diagram of a UV irradiation unit according to the present embodiment.
  • FIG. 2 is a view illustrating a YZ section of a flow channel and a peripheral portion of an ultraviolet LED lamp.
  • FIG. 3 is an exploded view of the UV irradiation unit of the present embodiment.
  • FIG. 4 is a configuration diagram at the time of inactivating a virus included in a blood product using the UV irradiation unit of the present embodiment.
  • FIG. 5 is a view illustrating a flow channel of a modified example.
  • the UV irradiation unit 1 includes a circuit unit 11 , an irradiation unit 12 , a feed pump 13 , a control unit 14 , and the like as illustrated in FIG. 1 .
  • XYZ axes orthogonal to each other are assumed as illustrated in FIG. 1 and the like for the convenience of description.
  • an X-axis direction is a direction (left-right direction in FIG.
  • the circuit unit 11 includes a plurality of tubes 21 , an attachment assist portion 22 , and the like.
  • the tube 21 includes a flow channel 41 for flow of the blood or the blood component.
  • the flow channel 41 corresponds to an inner cavity of the tube 21 .
  • the blood or the blood component is whole blood or concentrated erythrocytes, platelets, or plasma, and will be collectively simply referred to as “blood” hereinafter.
  • the tube 21 is made of a transparent resin that is disposable and does not contain a UV absorbent. As a result, it is possible to subject the blood flowing through the flow channel 41 to more UV light (ultraviolet light) emitted from a UV LED lamp 52 .
  • the circuit unit 11 includes one inlet-side tube 31 , a plurality of branch tubes 32 , and one outlet-side tube 33 as the plurality of tubes 21 . Further, the plurality of branch tubes 32 is connected to the inlet-side tube 31 and the outlet-side tube 33 . That is, the plurality of branch tubes 32 branching from the single inlet-side tube 31 is connected to the single outlet-side tube 33 in the circuit unit 11 . In this manner, the plurality of tubes 21 is integrated in the circuit unit 11 .
  • the branch tube 32 has a first portion 32 a whose axial direction (blood flow direction) is formed along a Z-axis direction and the second portion 32 b whose axial direction is formed along the X-axis direction.
  • the plurality of branch tubes 32 is arranged in parallel as illustrated in FIGS. 1 to 3 .
  • the second portions 32 b of the plurality of branch tubes 32 are arranged in parallel for each of a Y-axis direction (a first direction orthogonal to the axial direction (blood flow direction) of the flow channel 41 ) and the Z-axis direction (a second direction orthogonal to the axial direction of the flow channel 41 and the first direction).
  • a multilayer structure in which the plurality of flow channels 41 is arranged in parallel for each of the Y-axis direction and the Z-axis direction is formed in the UV irradiation unit 1 .
  • a flow channel section (a YZ section (a section formed in the Y-axis direction and the Z-axis direction)) of the flow channel 41 perpendicular to the axial direction of the flow channel 41 is formed in a flat shape as illustrated in FIG. 2 .
  • the flow channel section of the flow channel 41 is formed in the flat shape having the Y-axis direction as a longitudinal direction and the Z-axis direction as a traverse direction.
  • an outer shape of the flow channel section of the flow channel 41 is formed in, for example, an oval shape (a shape having a pair of mutually opposing linear portions and a pair of arc portions connecting both ends of the linear portions).
  • the second portion 32 b of the branch tube 32 is formed in a linear shape along the X-axis direction as illustrated in FIG. 1 .
  • the flow channel 41 at the second portion 32 b of the branch tube 32 (hereinafter simply referred to as the flow channel 41 of the branch tube 32 ) is formed in the linear shape in the axial direction (the X-axis direction).
  • the attachment assist portion 22 holds the second portions 32 b of the plurality of branch tubes 32 at a holding portion 22 a. In this manner, the attachment assist portion 22 holds the plurality of the tubes 21 that has been integrated.
  • the attachment assist portion 22 includes a handle 23 . Therefore, a worker can attach and detach to and from the circuit unit 11 from the irradiation unit 12 while gripping the handle 23 . In this manner, the attachment assist portion 22 functions as assistance that causes the circuit unit 11 to be easily attached to the irradiation unit 12 .
  • the irradiation unit 12 includes an LED arrangement portion 51 , the UV LED lamp 52 , and a groove portion 53 .
  • a plurality of the LED arrangement portions 51 is formed. As illustrated in FIG. 3 , for example, five LED arrangement portions 51 including a first LED arrangement portion 51 A to a fifth LED arrangement portion 51 E are formed as the plurality of LED arrangement portions 51 . Then, the first LED arrangement portion 51 A, the second LED arrangement portion 51 B, the third LED arrangement portion 51 C, the fourth LED arrangement portion 51 D, and the fifth LED arrangement portion 51 E are formed in this order in the Z-axis direction.
  • a plurality of the UV LED lamps 52 is provided.
  • the plurality of UV LED lamps 52 is arranged in the X-axis direction and the Y-axis direction in each of the first LED arrangement portion 51 A to the fifth LED arrangement portion 51 E. Further, the UV LED lamps 52 are arranged only in one row in the Z-axis direction in the first LED arrangement portion 51 A and the fifth LED arrangement portion 51 E. In addition, the UV LED lamps 52 are arranged in two rows in the Z-axis direction in the second LED arrangement portion 51 B, the third LED arrangement portion 51 C, and the fourth LED arrangement portion 51 D.
  • the UV LED lamp 52 irradiates the blood flowing through the flow channel 41 of the branch tube 32 with UV light in order to inactivate a virus included in the blood.
  • the UV light emitted from the UV LED lamp 52 may be any one of UV-A, UV-B, and UV-C, and particularly, UV-A and UV-B which are hardly reflected or absorbed by erythrocytes are desirably used.
  • a plurality of the groove portions 53 is formed, and the groove portion 53 is formed between the adjacent LED arrangement portions 51 . As a result, a gap is formed between the adjacent LED arrangement portions 51 . Further, the holding portion 22 a (the second portion 32 b of the branch tube 32 ) of the attachment assist portion 22 in the circuit unit 11 is arranged inside the groove portion 53 (see FIG. 2 ).
  • each of which includes a groove portion 53 A to a groove portion 53 D are formed as the plurality of groove portions 53 .
  • the groove portion 53 A is provided between the first LED arrangement portion 51 A and the second LED arrangement portion 51 B
  • the groove portion 53 B is provided between the second LED arrangement portion 51 B and the third LED arrangement portion 51 C
  • the groove portion 53 C is provided between the third LED arrangement portion 51 C and the fourth LED arrangement portion 51 D
  • the groove portion 53 D is formed between the fourth LED arrangement portion 51 D and the fifth LED arrangement portion 51 E.
  • the UV LED lamp 52 is arranged in such a direction that the irradiation direction of the UV light becomes the direction of the first groove portion 53 A.
  • the UV LED lamps 52 arranged in two rows in the Z-axis direction are arranged to be directed such that each irradiation direction of the UV light becomes a direction of the first groove portion 53 A and a direction of the second groove portion 53 B.
  • the UV LED lamps 52 arranged in two rows in the Z-axis direction are arranged to be directed such that each irradiation direction of the UV light becomes the direction of the second groove portion 53 B and a direction of the third groove portion 53 C.
  • the UV LED lamps 52 arranged in two rows in the Z-axis direction are arranged to be directed such that each irradiation direction of the UV light becomes the direction of the third groove portion 53 C and a direction of the fourth groove portion 53 D.
  • the UV LED lamps 52 are arranged to be directed such that an irradiation direction of the UV light becomes the direction of the fourth groove portion 53 D.
  • the UV LED lamps 52 are arranged at positions on both sides in the Z-axis direction with respect to the flow channel 41 of the branch tube 32 as illustrated in FIG. 1 . Further, the plurality of UV LED lamps 52 is arranged along the axial direction (the X-axis direction) of the flow channel 41 of the branch tube 32 .
  • the flow channels 41 of the branch tube 32 are arranged such that two are parallel in the Y-axis direction and four are parallel in the Z-axis direction in the example illustrated in FIG. 1 , but the number of the flow channels 41 arranged in parallel is not particularly limited.
  • the flow channels 41 of the branch tube 32 may be arranged such that two or more are arranged in parallel in the Y-axis direction and the Z-axis direction, only one is arranged in the Y-axis direction and two or more are arranged in parallel in the Z-axis direction, or two or more are arranged in parallel in the Y-axis direction and only one is arranged in the Z-axis direction.
  • the UV irradiation unit 1 includes a first feed pump 13 A and a second feed pump 13 B as the feed pump 13 .
  • the first feed pump 13 A is connected to the inlet-side tube 31 .
  • the second feed pump 13 B is connected to the outlet-side tube 33 .
  • the control unit 14 is configured using, for example, a microcomputer, and controls an operation of each component of the UV irradiation unit 1 such as drive of the feed pump 13 and irradiation of the UV LED lamp 52 .
  • a non-inactivated blood product bag 61 containing a blood product prior to inactivation of the virus and a dilute solution bag 62 containing a dilute solution (preserving liquid) are connected to the inlet-side tube 31 of the UV irradiation unit 1 as illustrated in FIG. 4 .
  • a tube 71 is connected to the inlet-side tube 31 of the UV irradiation unit 1 via the first feed pump 13 A.
  • the tube 71 is connected to a tube 72 connected to the non-inactivated blood product bag 61 and a tube 73 connected to the dilute solution bag 62 .
  • an inactivated blood product bag 63 configured to contain the blood product after virus inactivation is connected to the outlet-side tube 33 of the UV irradiation unit 1 as illustrated in FIG. 4 .
  • a tube 81 connected to the inactivated blood product bag 63 is connected to the outlet-side tube 33 of the UV irradiation unit 1 via the second feed pump 13 B.
  • control unit 14 drives the first feed pump 13 A and the second feed pump 13 B so as to cause the blood product to flow from the non-inactivated blood product bag 61 to the circuit unit 11 via the tube 72 and the tube 71 .
  • the blood product is diluted with the dilute solution flowing in the circuit unit 11 from the dilute solution bag 62 via the tube 73 and the tube 71 at this time.
  • control unit 14 irradiates the blood product flowing through the flow channel 41 of the branch tube 32 with UV light by the UV LED lamp 52 .
  • the virus included in the blood product is inactivated.
  • the blood product after virus inactivation is contained in the inactivated blood product bag 63 .
  • concentration of the blood product is lowered by being diluted with the dilute solution, the UV light is hardly absorbed or reflected by erythrocytes, and the processing performance to inactivate the virus is improved.
  • the function of the UV irradiation unit 1 has been described as above.
  • the plurality of flow channels 41 is arranged in parallel in the UV irradiation unit 1 of the present embodiment as described above. Specifically, the flow channels 41 of the plurality of branch tubes 32 are arranged in parallel in each of the Y-axis direction and the Z-axis direction. In this manner, the multilayer structure in which the plurality of flow channels 41 is arranged in parallel for each of the Y-axis direction and the Z-axis direction is formed in the UV irradiation unit 1 .
  • the UV LED lamp 52 which hardly generates heat is used as a light source for irradiation of UV light in the UV irradiation unit 1 , and thus, it is possible to simplify a heat dissipation measure.
  • the UV LED lamp 52 and the branch tube 32 can be arranged to be close to each other even within a limited space, and can be made multilayered. Therefore, it is possible to increase the volume of the flow channels 41 in the circuit unit 11 by arranging the plurality of branch tubes 32 in parallel to form the multilayer structure in which the plurality of flow channels 41 is arranged in parallel. Thus, it is possible to increase the throughput of blood per unit time in the entire UV irradiation unit 1 .
  • the UV LED lamps 52 are arranged at positions on both the sides in the Z-axis direction with respect to the flow channel 41 of the branch tube 32 in the UV irradiation unit 1 of the present embodiment as illustrated in FIG. 2 . In this manner, a double-sided irradiation structure in which the blood flowing through the flow channel 41 is irradiated with UV light from both the sides of the flow channel 41 is formed in the UV irradiation unit 1 . Thus, it is possible to increase an irradiation amount of UV light with respect to blood.
  • the UV light emitted from the UV LED lamp 52 arranged at a position on one side with respect to the flow channel 41 hits erythrocytes in the blood to be absorbed or reflected
  • the UV light emitted from the UV LED lamp 52 arranged at a position on the other side of the flow channel 41 can be transmitted into the blood without hitting the erythrocytes in the blood.
  • the UV light is easily transmitted into the blood.
  • the multilayer structure in which the plurality of flow channels 41 is arranged in parallel and the double-sided irradiation structure in which the blood flowing through the flow channel 41 is irradiated with UV light from both the sides of the flow channel 41 are formed in the UV irradiation unit 1 of the present embodiment.
  • the UV irradiation unit 1 it is possible to increase the irradiation amount of the UV light with respect to the blood while increasing the throughput of blood per unit time, and further, the UV light is easily transmitted into the blood in the UV irradiation unit 1 . Therefore, the processing performance to inactivate the virus included in the blood is improved so that it is possible to inactivate the virus included in the blood in a short time according to the UV irradiation unit 1 .
  • the blood is irradiated with UV light while causing the blood to flow in one direction from the upstream side to the downstream side inside the flow channel 41 , thereby inactivating the virus included in the blood in the UV irradiation unit 1 of the present embodiment.
  • the blood stagnation hardly occurs in the UV irradiation unit 1 as compared with a conventional case in which blood contained in a blood bag is irradiated with UV light (in the case of batch-type virus inactivation treatment), and thus, blood coagulation hardly occurs.
  • a length of the branch tube 32 that is, a length of the flow channel 41 of the branch tube 32 in the X-axis direction as short as possible.
  • the volume of the flow channel 41 in the circuit unit 11 is secured by arranging the plurality of flow channels 41 having a small flow channel area in parallel instead of securing the volume of the flow channel 41 in the circuit unit 11 by increasing a flow channel area (area of the above-described flow channel section) of the flow channel 41 .
  • a flow channel area area of the above-described flow channel section
  • blood coagulation may occur due to generation of a portion where blood stagnates in the flow channel 41 .
  • the flow channel area of the flow channel 41 can be made small in the UV irradiation unit 1 of the present embodiment, a portion where blood stagnates in the flow channel 41 is hardly generated, and the blood coagulation hardly occurs.
  • a blood product flows with erythrocytes floating inside the flow channel 41 particularly when the blood product of whole blood or concentrated erythrocytes are caused to flow through the flow channel 41 according to the UV irradiation unit 1 of the present embodiment, and thus, the UV light emitted from the UV LED lamp 52 is hardly absorbed or reflected by the erythrocytes.
  • the UV light is easily transmitted into the blood product, so that the virus included in the blood product is easily inactivated.
  • the flow channel section of the flow channel 41 is formed in the flat shape, and the UV LED lamp 52 is arranged at the position in the traverse direction (Z-axis direction) of the flat shape with respect to the flow channel 41 .
  • the UV LED lamp 52 is arranged at the position in the traverse direction (Z-axis direction) of the flat shape with respect to the flow channel 41 .
  • the UV light is easily transmitted into the blood flowing through the flow channel 41 .
  • the plurality of UV LED lamps 52 is arranged in the axial direction (X-axis direction) of the flow channel 41 of the branch tube 32 in the UV irradiation unit 1 of the present embodiment.
  • the UV irradiation unit 1 is formed so as to continuously irradiate the blood flowing through the flow channel 41 along the flow direction thereof.
  • the UV LED lamp 52 is less likely to generate heat as compared with a conventional UV lamp such as a mercury UV lamp, and thus, it suffices to simply take the heat dissipation measure.
  • the UV LED lamp 52 can be brought into close contact with the branch tube 32 as compared with the conventional UV lamp. Therefore, the groove portion 53 in the irradiation unit 12 can be made as small as possible, and thus, it is possible to make the flow channel 41 multilayered within a limited space.
  • the UV irradiation unit 1 can be miniaturized.
  • the life of the UV LED lamp 52 is remarkably increased as compared with the conventional UV lamp.
  • reduction in illuminance hardly occurs in the UV LED lamp 52 .
  • the performance of processing to inactivate the virus included in the blood hardly varies.
  • the illuminance of UV light of the UV LED lamp 52 is set to 30 W
  • the six flow channels 41 of the branch tube 32 are arranged in the Y-axis direction in five rows in the Z-axis direction
  • the length of the flow channel 41 of the branch tube 32 in the axial direction (X-axis direction) is set to 300 mm.
  • the flow channel 41 of the branch tube 32 may be formed in a curved shape in the axial direction thereof as a modified example.
  • the flow channel 41 of the branch tube 32 is formed such that the axis thereof is curved from the X-axis direction toward the Y-axis direction and further, is curved from the Y-axis direction toward the X-axis direction.
  • the volume of the flow channel 41 it is possible to secure the volume of the flow channel 41 .
  • a multilayer structure in which the plurality of flow channels 41 is arranged in parallel in the Z-axis direction is formed, and the UV LED lamps 52 are arranged at positions on both sides with respect to the flow channel 41 in the Z-axis direction.
  • the plurality of UV LED lamps 52 is arranged in the axial direction of the flow channel 41 .
  • the UV irradiation unit 1 of the present embodiment includes the flow channel 41 through which blood flows; and the UV LED lamp 52 which irradiates the blood flowing through the flow channel 41 with UV light in order to inactivate the virus included in the blood, in which the multilayer structure in which the plurality of flow channels 41 is arranged in parallel is formed.
  • the total volume of the flow channels 41 in the circuit unit 11 by forming the multilayer structure in which the plurality of flow channels 41 is arranged in parallel in the UV irradiation unit 1 .
  • it is possible to effectively inactivate the virus by the UV light and thus, the processing performance of inactivating the virus included in the blood is improved.
  • the blood is irradiated with the UV light while causing the blood to flow through the flow channel 41 , the blood stagnation hardly occurs so that the blood coagulation hardly occurs.
  • the blood coagulation hardly occurs, and it is possible to inactivate the virus included in the blood in a short time according to the UV irradiation unit 1 of the present embodiment.
  • the multilayer structure in which the plurality of flow channels 41 is arranged in parallel is formed for each of the Y-axis direction and the Z-axis direction in the UV irradiation unit 1 of the present embodiment.
  • the UV LED lamps 52 are arranged at positions on both sides with respect to the flow channel 41 in the Z-axis direction. As a result, it is possible to increase the irradiation amount of UV light with respect to the blood flowing through the flow channel 41 . In addition, the UV light is easily transmitted into the blood flowing through the flow channel 41 . Thus, the processing performance to inactivate the virus included in the blood is improved.
  • the flow channel section of the flow channel 41 is formed in the flat shape, and the UV LED lamp 52 is arranged at the position in the traverse direction (Z-axis direction) of the flat shape with respect to the flow channel 41 in the UV irradiation unit 1 of the present embodiment.
  • the UV LED lamp 52 is arranged at the position in the traverse direction (Z-axis direction) of the flat shape with respect to the flow channel 41 in the UV irradiation unit 1 of the present embodiment.
  • the plurality of UV LED lamps 52 is arranged in the axial direction of the flow channel 41 .
  • the processing performance to inactivate the virus included in the blood is improved.
  • the flow channel 41 of the branch tube 32 is formed in a linear shape in the axial direction thereof.
  • the blood flowing through the flow channel 41 hardly receives a flow channel resistance, and thus, it is possible to increase the throughput of the blood per unit time.
  • the flow channel 41 of the branch tube 32 may be formed in a curved shape in the axial direction thereof. As a result, it is possible to secure the volume of the flow channel 41 within a limited space, and thus, it is possible to increase the throughput of the blood per unit time.

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US16/086,989 2016-03-23 2017-03-22 Light irradiation device Abandoned US20190099543A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016059057 2016-03-23
JP2016-059057 2016-03-23
PCT/JP2017/011326 WO2017164202A1 (fr) 2016-03-23 2017-03-22 Dispositif d'irradiation de lumière

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PCT/JP2017/011326 A-371-Of-International WO2017164202A1 (fr) 2016-03-23 2017-03-22 Dispositif d'irradiation de lumière

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US17/347,826 Continuation US20210308360A1 (en) 2016-03-23 2021-06-15 Light irradiation device

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US17/347,826 Pending US20210308360A1 (en) 2016-03-23 2021-06-15 Light irradiation device

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JP (1) JP6895426B2 (fr)
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US11554185B2 (en) 2017-12-29 2023-01-17 Cerus Corporation Systems and methods for treating biological fluids
US11771814B2 (en) 2018-07-27 2023-10-03 Terumo Bct Biotechnologies, Llc Flow cell
US11883544B2 (en) 2019-06-28 2024-01-30 Cerus Corporation System and methods for implementing a biological fluid treatment device
WO2024025718A1 (fr) * 2022-07-25 2024-02-01 Nixon Dale Appareil à cassette pour le traitement du sang pour neutraliser des cellules pathogènes contenues dans celui-ci
US12011510B2 (en) 2019-06-22 2024-06-18 Cerus Corporation Biological fluid treatment systems

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US20210308360A1 (en) 2021-10-07
CN108778357B (zh) 2021-12-03
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JP6895426B2 (ja) 2021-06-30
CN108778357A (zh) 2018-11-09
WO2017164202A1 (fr) 2017-09-28
EP3434295B1 (fr) 2022-03-09
JPWO2017164202A1 (ja) 2019-02-07

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