US20190029313A1 - Tobacco compositions - Google Patents

Tobacco compositions Download PDF

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Publication number
US20190029313A1
US20190029313A1 US16/146,474 US201816146474A US2019029313A1 US 20190029313 A1 US20190029313 A1 US 20190029313A1 US 201816146474 A US201816146474 A US 201816146474A US 2019029313 A1 US2019029313 A1 US 2019029313A1
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US
United States
Prior art keywords
tobacco
smokeless tobacco
tobacco composition
flavor
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
US16/146,474
Inventor
James A. Strickland
Frank S. Atchley
James M. Rossman
Armand J. Desmarais
Scott A. Williams
Tod J. Miller
Cherne W. Johnson
Vernie A. Due
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Smokeless Tobacco Co LLC
Original Assignee
US Smokeless Tobacco Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Smokeless Tobacco Co LLC filed Critical US Smokeless Tobacco Co LLC
Priority to US16/146,474 priority Critical patent/US20190029313A1/en
Publication of US20190029313A1 publication Critical patent/US20190029313A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/79—Fixation, conservation, or encapsulation of flavouring agents in the form of films
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Definitions

  • the invention relates to the field of tobacco products.
  • compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.
  • any composition described herein may include a flavor or flavor masking agent.
  • flavors include licorice, kudzu, hydrangea, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, menthol, Japanese mint, aniseed, cinnamon, herb, wintergreen, cherry, berry, apple, peach, Dramboui, bourbon, scotch, whiskey, spearmint, peppermint, lavender, cardamon, apium graveolens, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia, caraway, cognac, jasmin, ilangilang, sage, fennel, piment, ginger, anise, coriander, coffee, or a mint oil from any species of the genus Mentha.
  • composition of the invention may also include a sweetener (such as sucrose, sucralose, acesulfame potassium, aspartame, saccharine, cyclamates, lactose, sucrose, glucose, fructose, sorbitol, and mannitol); a surfactant; a plasticizer (such as glycerine, propylene glycol, polyethylene glycol, sorbitol/mannitol, acetylated monoglycerides, triacetin, and 1,3 butane diol); a filler (such as starch, microcrystalline cellulose, wood pulp, soluble fiber, calcium carbonate, dicalcium phosphate, calcium sulfate, and a clay); a lubricant (such as stearic acid and a stearate) or a wax (such as lecithin, glycerol monostearate, and propylene glycol monostearate); a preservative (such as methyl paraben
  • composition described herein may further include a coating, e.g., matte or glossy.
  • the coating preferably includes a color, flavor, sweetener, or flavor masking agent.
  • the coating may also include a different flavor, color, or rate of disintegration from the format in the composition.
  • the coating may also include tobacco.
  • composition described herein may further include a printed pattern, e.g., in a logo.
  • a printed pattern may include a color, tobacco, a flavor, sweetener, or flavor masking agent.
  • the surface of any composition described herein may also include a pattern in relief.
  • Tobacco included in any composition may be a powder, granules, shreds, or perceived to be soluble in the mouth.
  • composition described herein may further include flakes, e.g., containing tobacco or a plurality of flavors or colors.
  • composition of the invention may be formed in a shape suitable for application in the mouth.
  • a composition of the invention may further provide tobacco satisfaction, e.g., over a period of 10 s to 30 minutes.
  • the invention also features a method for obtaining tobacco satisfaction by placing at least a portion of any composition as described herein in the mouth.
  • the invention also features methods for making compositions as described herein. Any of these methods may further include adding a coating to the composition, e.g., by spraying, brushing, roll coating, doctor bar casting, slot coating, extrusion coating, or hot melt deposition. Any of the methods may also include printing a pattern on the composition, e.g., by offset, flexographic, gravure, ink jet, laser, or screen printing. In addition, the methods of making compositions may include adding a flavor, color, flavor masking agent, or any other ingredient described herein to the format or composition.
  • format is meant an ingredient or compilation of ingredients, as provided herein, in a composition, for example, a carrier or agent.
  • tobacco any part, e.g., leaves, flowers, roots, and stems, of any member of the genus Nicotiana .
  • Exemplary species of tobacco include N. rustica and N. tabacum (e.g., LA B21, LN KY171, TI 1406, Basma, Galpao, Perique, Beinhart 1000-1, and Petico).
  • Other species include N. acaulis, N. acuminata, N. acuminata var. multiflora, N. africana, N. alata, N. amplexicaulis, N. arentsii, N. attenuata, N. benavidesii, N. benthamiana, N. bigelovii, N.
  • N. cavicola bonariensis, N. cavicola, N. clevelandii, N. cordifolia, N. corymbosa, N. debneyi, N. excelsior, N. forgetiana, N. fragrans, N. glauca, N. glutinosa, N. goodspeedii, N. gossei, N. hybrid, N. ingulba, N. kawakamii, N. knightiana, N. langsdorffii, N. linearis, N. longiflora, N. maritima, N. megalosiphon, N. miersii, N. noctiflora, N. nudicaulis, N. obtusifolia, N. occidentalis, N.
  • the tobacco may be whole, shredded, cut, cured, aged, fermented, or otherwise processed, e.g., granulated or encapsulated.
  • Tobacco may also be in the form of finished products, including but not limited to any non-combustible tobacco that is orally consumed, e.g., smokeless tobacco.
  • smokeless tobacco includes snuff (moist or dry), chewing tobacco, loose tobacco, pouched tobacco, and the like, or any form contained herein.
  • the term also includes an extract of tobacco including two or more tobacco organoleptic components.
  • tobacco satisfaction in this case, is meant the experience associated with tobacco organoleptic components and added flavor components that are released in the mouth when using a smokeless tobacco.
  • An adult consumer who chooses to use a smokeless tobacco product purchases a smokeless tobacco product typically according to their individual preference, such a preference includes, without limitation, flavor, cut of tobacco, form, ease of use, and packaging.
  • organoleptic is meant relating or contributing to the integrated sensory perception by the consumer that includes, for example, any combination of aroma, fragrance, flavor, taste, odor, mouth feel, or the like.
  • non-combustible does not combust during ordinary usage.
  • compositions described herein are advantageous from the perspective of size, ease of use, and controlled rate of disintegration.
  • the invention features tobacco compositions that are typically for tobacco satisfaction.
  • Tobacco useful in compositions described herein includes any raw or processed form, e.g., a powder, granule, or shred.
  • the tobacco is sized or made to disintegrate in the mouth (e.g., dissolve), to give the perception of dissolvability (e.g., the tobacco does not produce a tactile experience in the mouth), or to be easily swallowed.
  • the tobacco may be sized or made to provide a tactile experience in the mouth. Exemplary average sizes are in the range of 1 to 1000 ⁇ m, e.g., about 800, 500, 250, 100, 80, 75, 50, 25, 20, 15, 10, 8, 6, 5, 3, 2, or 1 ⁇ m or less, preferably 80 ⁇ m or less.
  • the tobacco may also be in the form of a slurry or a flowable gel.
  • a flowable gel is a mixture of a format dissolved in water and mixed with tobacco and then mixed with a miscible solvent that prevents the complete dissolution of the format. Such a mixture causes the format to swell forming a viscous paste that is pseudoplastic and is easily dispensed from a container (e.g., a tube) with slight pressure.
  • An exemplary tobacco is smokeless tobacco. Additional tobaccos are described in U.S. Publication Nos. 2003/0094182, 2003/0070687, and 2006/0037623 and U.S. Ser. No. 60/603,887; the disclosures of which are hereby incorporated by reference.
  • the tobacco employed in the composition may also be prepared according to the methods of U.S. Publication No. 2004/0112394; the disclosure of which is hereby incorporated by reference. Other suitable tobacco is known in the art.
  • Tobacco may be distributed randomly or evenly throughout a composition or concentrated in various regions thereof, e.g., in the center or on the surface.
  • the typical final tobacco concentration ranges from 1 percent to 99 percent by weight of the final composition, for example, at most 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, or 90%.
  • the composition includes around 25% tobacco.
  • compositions of the invention are intended for oral use or consumption.
  • a composition containing tobacco may be manufactured using any suitable orally compatible format.
  • the tobacco may be mixed directly with the format or otherwise supported by the format.
  • a composition may contain tobacco, e.g., as dried particles, shreds, granules, a powder, or a slurry, deposited on, mixed in, surrounded by, or otherwise combined with a format.
  • Tobacco in compositions may or may not be, or be perceived to be, soluble.
  • the compositions are spitless tobacco compositions.
  • Compositions may also include a mixture of forms or types of tobacco.
  • Compositions may be foamed or dense. Foamed compositions may be rigid or flexible and may be based on water soluble, water insoluble, or thermoplastic formats. Exemplary compositions are described herein.
  • a composition of the invention is non-combustible.
  • Formats suitable for use in the compositions described herein include orally compatible polymers, such as cellulosics (e.g., carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), hydroxypropyl methyl cellulose (HPMC), and methyl cellulose (MC)), natural polymers (e.g., starches and modified starches, konjac, collagen, inulin, soy protein, whey protein, casein, and wheat gluten), seaweed-derived polymers (e.g., carrageenan (kappa, iota, and lambda), alginates, and propylene glycol alginate), microbial-derived polymers (e.g., xanthan, dextran, pullulan, curdlan, and gellan), extracts (e.g., locust bean gum, guar gum, tara gum, gum tragacanth, pectin (lo methoxy and amidated), a
  • a composition may also include fillers (e.g., starch, microcrystalline cellulose, wood pulp (e.g., Solkafloc from International Fibers, Inc.), soluble fiber (e.g., Fibersol from Matsushita), calcium carbonate, dicalcium phosphate, calcium sulfate, and clays), lubricants (e.g., lecithin, stearic acid, stearates (e.g., Mg or K), and waxes (e.g., glycerol monostearate, propylene glycol monostearate, and acetylated monoglycerides)), plasticizers (e.g., glycerine, propylene glycol, polyethylene glycol, sorbitol, mannitol, triacetin, and 1,3 butane diol), stabilizers (e.g., ascorbic acid and monosterol citrate, BHT, or BHA), or other compounds (e.g., ascor
  • Compositions of the invention may include flavor extracts (e.g., licorice, kudzu, hydrangea, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, menthol, Japanese mint, aniseed, cinnamon, herb, wintergreen, cherry, berry, peach, apple, Dramboui, bourbon, scotch, whiskey, spearmint, peppermint, lavender, cardamon, apium graveolens, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia, caraway, cognac, jasmin, ilangilang, sage, fennel, piment, ginger, anise, coriander, coffee, or a mint oil from any species of the genus Mentha), flavor masking agents, bitterness receptor site blockers, receptor site enhancers, sweeteners (e.g., sucralose,
  • Flavors may also be provided by plant matter, e.g., mint leaves, which are typically 10% flavor oils and 90% insoluble fiber.
  • Exemplary plants further include licorice, kudzu, hydrangea, Japanese white bark magnolia, chamomile, fenugreek, clove, Japanese mint, cinnamon, herb, cherry, berry, peach, apple, lavender, cardamon, apium graveolens, cascarilla, nutmeg, sandalwood, bergamot, geranium, rose, vanilla, lemon, orange, cassia, caraway, jasmin, ilangilang, sage, fennel, piment, ginger, anise, coriander, coffee, or any species of the genus Mentha.
  • Flavor may be provided to a composition as described herein by flavor extracts, plant matter, or a combination thereof. In addition to natural flavor extracts, flavor may also be provided by imitation, synthetic, or artificial flavor ingredients and blends containing such ingredients. Flavors may be added as a powder, an oil, or in encapsulated form.
  • the composition disintegrates in the mouth. Disintegration rates of compositions may vary from 60 minutes to less than 1 minute.
  • Fast release compositions typically disintegrate in under 2 minutes and most preferably, in 1 minute or less, e.g., less than 60 s, 50 s, 45 s, 40 s, 35 s, 30 s, 25 s, 20 s, 15 s, 10 s, 5 s, 4 s, 3 s, 2 s, or 1 s.
  • the disintegration may occur by any mechanism, for example, dissolution, melting, mechanical disruption (e.g., from chewing), enzymatic or other chemical degradation, or disruption of the interaction between the format and tobacco.
  • the format or tobacco itself may similarly disintegrate.
  • the amount of time required for a composition to disintegrate may be controlled by varying the thickness of the composition and is dependent upon the type of format, other additives, and the pattern of usage.
  • the composition When placed in the mouth, the composition may temporarily adhere to a part of the oral mucosa.
  • the length of time of the tobacco satisfaction may vary. This length of time may be affected by, e.g., by the rate of disintegration of a composition, the rate of extraction of organoleptic components from a composition, and the residence time of the composition in the mouth.
  • the tobacco satisfaction may be provided over a period of at least 10 s, 30 s, 45 s, 1 min 2 min 3 min 5 min 10, min 15 min, 30 min, or 1 h, preferably from 10 s to 10 minutes and more preferably from 30 s to 5 minutes.
  • compositions do not disintegrate over the residence period in the mouth.
  • introduction of tobacco organoleptic components into the mouth may occur by dissolution, leaching, extraction, or mechanical disruption caused by chewing.
  • compositions may be sized to fit entirely in the mouth, or they may be sized to fit only partially in the mouth.
  • Preferred cross sections of the compositions include, but are not limited to, square, circular, rectangular, elliptical, oval, and the like.
  • Preferred dimensions may vary depending upon the serving size and ingredients. Typically, the largest dimension of a single serving is 5 cm or smaller.
  • tobacco products may be made in a larger form, from which individual servings may be cut or otherwise separated, e.g., by chewing, biting, or oral disintegration. For example, a strip, or other long piece, may be placed in a container, and the consumer may remove a desired serving size.
  • a larger composition (or orally sized piece attached to a handle) may also be partially inserted in the mouth, similar to a toothpick or cigarette, and the consumer may suck or chew on it.
  • the larger piece is orally disintegrable and may be completely consumed over a period of time.
  • Films Compositions of the invention may be formed as films that may be orally disintegrable. Such films may contain a single layer or multiple layers. A single layer film will contain tobacco, a format, and other ingredients, e.g., in a homogeneous mixture. Multilayer films may include several tobacco containing layers, e.g., with the same or different kind or size of tobacco, e.g., tobacco perceived to be soluble. Multiple layers may be laminated together. In addition, multilayer films may contain tobacco in one or more layers and other layers that contain additional ingredients, as described herein. For example, individual layers may be added for flavor, sweetness, color, rate of disintegration, or stability (e.g., during handling or during consumption).
  • Tobacco may also be placed between two or more layers in a sandwich arrangement.
  • One or more of the layers in the sandwich may also include tobacco.
  • the layers may disintegrate at the same or different rates, or a layer may not disintegrate orally.
  • rates of disintegration differ, the composition may provide tobacco at differing times based on the layers disintegrating.
  • Single layer films or individual layers in multilayer films may also be foamed or aerated to provide desirable physical properties or desirable dissolution or disintegration rates.
  • Films may be sized to fit in the mouth as individual servings. Alternatively, larger films may be fabricated from which individual servings may be separated. For example, a film may be wrapped, or otherwise shaped, to form a hollow tube or straw, which in turn may be filled with additional material.
  • a film e.g., containing a high percentage of tobacco in the range of 1% to 99% based on dry weight, may be fabricated and then used in preparation of flakes or a powder for addition to other compositions, as described herein.
  • the preferred thickness of a film is typically less than 1 mm, e.g., less than 500, 200, 100, 50, 40, 30, 20, 10, 5, 4, 3, 2, or 1 ⁇ m; preferably 5 to 125 ⁇ m.
  • films can be manufactured using various methods known in the art. The technique employed may depend on the format employed in the film. Exemplary methods include solution casting or extrusion, melt extrusion, drum drying, and calendaring.
  • a film may be modified, e.g., by printing or otherwise coating or decorating the surface of the film. Flavors, colors, or tobacco may be added to the surface of a film by a printing, coating, or decorative process. All printing processes known in the art, e.g., offset, flexographic, gravure, ink jet, laser, screen printing, and other typical methods, may be used.
  • Coatings or decorative patterns may be applied to the surface of the film using processes known in the art, e.g., spraying, brushing, roll coating, doctor bar casting, slot coating, extrusion coating, hot melt deposition, depositing particles or flakes, and other typical methods.
  • the film to be printed, coated, or decorated may or may not contain tobacco.
  • One function of the printing, coating, or decorative pattern is to provide additional amounts of color, flavor, or tobacco to the film. Another function is to improve the dimensional stability and appearance of the film.
  • an additional layer of film may be applied to cover, protect and seal the printed, coated, or decorated surface.
  • Example (%) (%) A (%) Water soluble polymer 10-70 20-45 30 Tobacco 1-90 20-40 25 Flavor 1-40 5-15 10 Sweetener 0.2-6 2-5 3 Fiber (Soluble or insoluble) 2-40 5-20 9 Plasticizer 1-40 5-15 10 Surfactants 0.05-5 0.1-1 0.5 Starch/Maltodextrin 1-40 10-20 10.5 Lubricant 0.5-10 1-3 2
  • HPMC hydroxypropylmethyl cellulose
  • a portion of this tobacco containing solution described above is then spread on a glass plate using a draw down blade with a fixed gap of 15 mils (0.015 inches).
  • the glass plate is placed in an air circulating laboratory oven preset at a temperature of 170° F. After 30 minutes, the glass plate is removed from the oven, cooled to room temperature, and the dry film with a thickness of 2.5 mils (0.0025 inches) is removed from the glass plate.
  • the film may then be cut into smaller pieces suitable for placing in the mouth.
  • a 1.0 inch by 1.25 inch section of the film will typically disintegrate in the mouth in less than one minute, thereby releasing the flavor, sweetener, and tobacco.
  • the tobacco content of this film on a dry weight basis is 25%.
  • Example B Using the same procedure as Example B, a solution is prepared without the addition of tobacco. While the solution is still hot, 32 grams of a titanium dioxide dispersion (50% titanium dioxide in water) supplied by Sensient Colors and 0.01 grams of FD&C Red No. 40 lake (Sensient Colors) are added with agitation. The solution is cooled to 65° F. and is spread on a glass plate, dried, and removed from the glass plate as described in Example B. An opaque, light red film of good strength and a dry film thickness of 1.5 mils (0.015 inches) is produced.
  • a titanium dioxide dispersion 50% titanium dioxide in water supplied by Sensient Colors and 0.01 grams of FD&C Red No. 40 lake (Sensient Colors) supplied with agitation.
  • the solution is cooled to 65° F. and is spread on a glass plate, dried, and removed from the glass plate as described in Example B. An opaque, light red film of good strength and a dry film thickness of 1.5 mils (0.015 inches) is produced.
  • Example B A portion of the solution from Example B is spread on a glass plate using a draw down blade with a fixed gap of 15 mils (0.015 inches). The glass plate is placed in a laboratory oven and the film is dried as in Example B. The glass plate is removed from the oven and cooled to room temperature, but the film is not removed from the glass plate.
  • Example C A portion of the solution from Example C is spread over the dry film of Example B using a draw down blade with a fixed gap of 5 mils (0.005 inches).
  • the glass plate is placed in the laboratory oven at 170° F. for 10 minutes.
  • the dry film with a thickness of 3 mils (0.003 inches) is removed from the glass plate.
  • the film is distinctly two sided with a layer of brown, tobacco containing film on one side and a red, flavored film on the opposite side. A 1.0 inch by 1.25 inch section of the film will typically disintegrate in the mouth in less than one minute.
  • a portion of the solution from Example C is spread on a glass plate using a draw down blade with a fixed gap of 5 mils and is dried in the laboratory oven as before.
  • a portion of the solution from Example B is spread over the dried film of Example C using a draw down blade with a fixed gap of 15 mils and is dried in the laboratory oven as before.
  • a portion of the solution from Example C is spread on a glass plate using a draw down blade with a fixed gap of 5 mils and is dried in the laboratory oven as before.
  • the resulting film is 3 mils (0.003 inches) in thickness and is comprised of three layers with a layer of opaque, red, flavored film on either side and a center layer of tobacco containing film. A 1.0 inch by 1.25 inch section of the film will typically disintegrate in the mouth in less than one minute.
  • Example B To a 100 gram portion of tobacco containing solution from Example B is added with vigorous mixing, 0.5 grams of sodium lauryl sulfate (a surface active agent). This solution is then mixed on a high shear mixer such as a Silverson Laboratory Homogenizer, Model L4RT-W, to create a uniform bubble structure. This highly aerated solution is then spread on a glass plate using a draw down blade with a fixed gap of 4 mils (0.040 inches) and is dried in a laboratory oven. The dry, foamed film has a thickness of 4 mils (0.004 inches) when it is removed from the glass plate.
  • a high shear mixer such as a Silverson Laboratory Homogenizer, Model L4RT-W
  • the weight of a section of this foamed film of 1.0 inch by 1.25 inch by 4 mils (0.004 inches) in thickness is 35% lower than an identical section of unfoamed film as prepared in Example B.
  • the dissolution rate of the foamed film in the mouth is typically faster when compared to the identical unfoamed film as prepared in Example B.
  • a solution is prepared in a beaker by adding 40 grams of spray dried Gum Arabic (TIC Gums, Inc.) and 0.4 grams of propylene glycol monostearate (PGMS) to 60 grams deionized water while mixing vigorously for 30 minutes.
  • PGMS propylene glycol monostearate
  • To 10 grams of this solution 0.01 grams of FD&C Red No. 40 lake is added with high agitation to ensure uniform dispersion of the color.
  • the solution is covered and set aside for 24 hours to permit all entrapped air to dissipate.
  • a portion of this solution is then spread on a glass plate using a fig down blade with a fixed gap of 5 mils (0.005 inches).
  • the glass plate is placed in a laboratory oven preset at 170° F. for 20 minutes until the film is thoroughly dried. When the film is removed from the glass plate, it breaks into many small pieces of high gloss, colorful, red flakes. This process is repeated with other FD&C lakes to produce flakes of many different colors.
  • Example G To 10 grams of the solution prepared in Example G is added 4 grams of finely ground tobacco powder. Films are prepared on glass plates and are dried, cooled, and removed in the same manner as in Example G. The resulting flakes are composed of 50% tobacco and 50% Gum Arabic and are a deep brown color. Flavors, if desired, can be added to the flakes. Materials such as sodium carbonate can also be added to the flakes to adjust pH.
  • a film is prepared as in Example B. While the film is still wet on the glass plate, a measured quantity of flakes are prepared and are spread uniformly over the wet film. The glass plate is then dried in a laboratory oven; the film is cooled to room temperature and then removed from the glass plate. Typically, the dried film of Example B has a dry weight of 1 gram (containing 25% or 0.25 grams of tobacco). If this film is divided into 20 equal sections of film (1.0 inch by 1.25 inches by 2 mils), each section will weigh 50 milligrams (containing 25% or 12.5 milligrams of tobacco).
  • each section will weigh 100 milligrams and will contain 37.5 milligrams of tobacco.
  • the section of film cut into a 1.0 inch by 1.25 inch size will typically disintegrate in the mouth in less than one minute.
  • Example I The procedure outlined in Example I can be repeated using decorative flakes (e.g., colored flakes which do not contain any tobacco) or with blends of colored flakes and tobacco containing flakes.
  • the resulting films have a colorful appearance.
  • a total of 619.14 g of boiling water was weighed into a stainless steel container.
  • the water was stirred vigorously with an Arrow Model 1750 high shear mixer.
  • MIX2 To the water was added MIX2.
  • Stirring was continued for 30 seconds, at which point MIX1 was added.
  • Vigorous stirring was continued for 4 minutes.
  • the resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum.
  • the vessel was attached to a Silverson L4RTU homogenizer motor unit.
  • the solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10,000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • a portion of the resultant gel solution was poured onto a glass plate that had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 15 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 30 minutes, which had been set at 75° C.
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet and cut into appropriately sized units.
  • a 1.0 inch by 1.25 inch unit of film disintegrated in the mouth in less than 30 seconds.
  • Relatively slower disintegrating films e.g., films disintegrating in the mouth in greater than 30 seconds
  • films disintegrating in the mouth in greater than 30 seconds were produced from the same solutions by casting the solution across the glass plate with a draw-down knife with a fixed gap of 30 mils.
  • the films were dried in the same manner as above for 40 minutes.
  • the films produced typically disintegrated in the mouth in less than 1 minute.
  • Super-fast disintegrating films e.g., films disintegrating in the mouth in less than 15 seconds
  • foaming was accomplished by subjecting 100 g of each solution to high shear mixing (with an Arrow Model 1750 high shear mixer) for approximately 3 minutes, after which the foamed solution was immediately cast on the glass plate with a draw-down knife with a fixed gap of 30 mils.
  • the films produced typically disintegrated in the mouth in less than 15 seconds.
  • a total of 619.14 g of boiling water was weighed into a stainless steel container.
  • the water was stirred vigorously with an Arrow Model 1750 high shear mixer.
  • MIX2 To the water was added MIX2.
  • Stirring was continued for 30 seconds, at which point MIX1 was added.
  • Vigorous stirring was continued for 4 minutes.
  • the resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum.
  • the vessel was attached to a Silverson L4RTU homogenizer motor unit.
  • the solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • a portion of the resultant gel solution was poured onto a glass plate that had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 15 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 30 minutes, which had been set at 75° C.
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet and cut into appropriately sized units.
  • the film includes wintergreen, spearmint, or apple flavor.
  • Relatively slower disintegrating films e.g., films disintegrating in the mouth in greater than 30 seconds
  • super-fast disintegrating films e.g., films disintegrating in the mouth in less than 15 seconds
  • MIX1 HM3PA2910 (Wolff Cellulosics) 30.98 g HM100PA2208 (Wolff Cellulosics) 15.51 g HM4000PA2910 (Wolff Cellulosics) 2.60 g B700 (Grain Processing Corporation) 16.36 g Tobacco Powder (average particle size ⁇ 80 ⁇ m) 32.72 g
  • MIX3 Glycerin 1.31 g Propylene Glycol 1.31 g Polyethylene Glycol 400 1.31 g Peach Puree 100.0 g Peach Flavor 3.27 g Tobacco Flavor Modifier (Hagelin) 2.62 g Sucralose Solution 25% (Tate & Lyle) 2.62 g
  • a total of 619.14 g of boiling water was weighed into a stainless steel container.
  • the water was stirred vigorously with an Arrow Model 1750 high shear mixer.
  • MIX2 To the water was added MIX2.
  • Stirring was continued for 30 seconds, at which point MIX1 was added.
  • Vigorous stirring was continued for 4 minutes.
  • the resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum.
  • the vessel was attached to a Silverson L4RTU homogenizer motor unit.
  • the solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • a portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 15 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 30 minutes, which had been set at 75° C.
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and cut into appropriately sized units.
  • Relatively slower disintegrating films e.g., films disintegrating in the mouth in greater than 30 seconds
  • super-fast disintegrating films e.g., films disintegrating in the mouth in less than 15 seconds
  • HM3PA2910 (Wolff Cellulosics) 38.48 g HM100PA2208 (Wolff Cellulosics) 19.27 g HM4000PA2910 (Wolff Cellulosics) 3.24 g B700 (Grain Processing Corporation) 20.32 g Tobacco Powder (avg. particle size ⁇ 80 ⁇ m) 14.39 g
  • a total of 606.10 g of boiling water was weighed into a stainless steel container.
  • the water was stirred vigorously with an Arrow Model 1750 high shear mixer.
  • MIX2 To the water was added MIX2.
  • Stirring was continued for 30 seconds, at which point MIX1 was added.
  • Vigorous stirring was continued for 4 minutes.
  • the resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum.
  • the vessel was attached to a Silverson L4RTU homogenizer motor unit.
  • the solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • a portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C.
  • VWR model 1330FM side-swept forced air oven
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and was stored in a plastic bag for future use.
  • flavored tobacco films e.g., apple flavored, were also produced following the preceding formulation and procedure.
  • HM3PA2910 (Wolff Cellulosics) 38.48 g HM100PA2208 (Wolff Cellulosics) 19.27 g HM4000PA2910 (Wolff Cellulosics) 3.24 g B700 (Grain Processing Corporation) 20.32 g Fibersol-2 (Matsutani) 14.39 g FD&C Red 40 Alum Lake 35-42% (Sensient Colors) 0.29 g
  • a total of 606.10 g of boiling water was weighed into a stainless steel container.
  • the water was stirred vigorously with an Arrow Model 1750 high shear mixer.
  • MIX2 To the water was added MIX2.
  • Stirring was continued for 30 seconds, at which point was added MIX1.
  • Vigorous stirring was continued for 4 minutes.
  • the resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum.
  • the vessel was attached to a Silverson L4RTU homogenizer motor unit.
  • the solution was homogenized under vacuum (20-25 inches) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • a portion of the resultant gel solution was poured onto a glass plate that had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C. Additional films were cast at 40 mils, and dried for 1 hour.
  • the resultant films dried to approximately 4% moisture, were removed from the Mylar sheet, and were stored in a plastic bag for future use.
  • flavors include mint flavor, wintergreen flavor, or spearmint flavor.
  • Alternative colors include FD&C Blue Alum Lake 35-42%, FD&C Emerald Green Lake Blend, and FD&C Blue Alum Lake+FD&C Emerald Green Lake Blend.
  • HM3PA2910 (Wolff Cellulosics) 38.48 g HM100PA2208 (Wolff Cellulosics) 19.27 g HM4000PA2910 (Wolff Cellulosics) 3.24 g B700 (Grain Processing Corporation) 20.32 g Tobacco Powder (average particle size ⁇ 80 ⁇ m) 14.39 g
  • a total of 606.10 g of boiling water was weighed into a stainless steel container.
  • the water was stirred vigorously with an Arrow Model 1750 high shear mixer.
  • MIX2 To the water was added MIX2.
  • Stirring was continued for 30 seconds, at which point was added MIX1.
  • Vigorous stirring was continued for 4 minutes.
  • the resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum.
  • the vessel was attached to a Silverson L4RTU homogenizer motor unit.
  • the solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • a portion of the resultant gel solution was poured onto a glass plate that had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C.
  • VWR model 1330FM side-swept forced air oven
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and was stored in a plastic bag for future use.
  • HM3PA2910 (Wolff Cellulosics) 38.48 g HM100PA2208 (Wolff Cellulosics) 19.27 g HM4000PA2910 (Wolff Cellulosics) 3.24 g B700 (Grain Processing Corporation) 20.32 g Fibersol-2 (Matsutani) 14.39 g
  • a total of 606.10 g of boiling water was weighed into a stainless steel container.
  • the water was stirred vigorously with an Arrow Model 1750 high shear mixer.
  • MIX2 To the water was added MIX2.
  • Stirring was continued for 30 seconds, at which point was added MIX1.
  • Vigorous stirring was continued for 4 minutes.
  • the resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum.
  • the vessel was attached to a Silverson L4RTU homogenizer motor unit.
  • the solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • a portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C.
  • VWR model 1330FM side-swept forced air oven
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and was stored in a plastic bag for future use.
  • Klucel LF Hercules/Aqualon
  • Na 2 CO 3 181.0 g
  • Sucralose (Tate & Lyle) 45.0 g
  • Propylene Glycol 363.0 g
  • Tobacco Powder average particle size ⁇ 80 ⁇ m
  • the tobacco granulation was introduced to the feed section of a Leistritz Micro-18 Twin Screw Extruder 40:1 L/D, which had been configured for co-rotating extrusion with a medium-shear screw design. Feed rates for the extrusion varied between 1-3 pounds per hour. Barrel zone temperatures varied between 75-240° F. Venting of volatiles from the extrusion melt was accomplished by incorporating a venting orifice prior to the discharge die of the extruder.
  • Tobacco film with a width of approximately 3 inches and a thickness varying from 2-3 mils, was produced by incorporating a strip die at the discharge end of the extruder.
  • the tobacco film was calendared and cooled to room temperature by utilizing a 3-roll stacked chill roller. Downstream from the chill roller the film was taken up on a rewind reel, incorporating Mylar between the film layers to prevent adhesion.
  • the tobacco film was placed in a container suitable for storage.
  • the tobacco film was subsequently used in the manufacture of dissolvable tobacco containing pouches, as described herein.
  • the film disintegrated slowly in the mouth, over a period of 2-4 minutes.
  • HM3PA2910 (Wolff Cellulosics) 13.84 g HM100PA2208 (Wolff Cellulosics) 7.24 g HM4000PA2910 (Wolff Cellulosics) 1.21 g B700 (Grain Processing Corporation) 7.63 g Gelatin 0.61 g Tobacco Powder (average particle size ⁇ 80 ⁇ m) 15.27 g
  • a portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C.
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and cut into appropriately sized units.
  • a 1.0 inch by 1.25 inch unit of film dissolved in the mouth in less than 30 seconds, releasing flavor, sweetener, and tobacco.
  • HM3PA2910 (Wolff Cellulosics) 11.40 g HM100PA2208 (Wolff Cellulosics) 7.24 g HM4000PA2910 (Wolff Cellulosics) 1.21 g B700 (Grain Processing Corporation) 7.63 g Gelatin 3.05 g Tobacco Powder (average particle size ⁇ 80 ⁇ m) 15.27 g
  • a portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C.
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and cut into appropriately sized units.
  • a 1.0 inch by 1.25 inch unit of film disintegrated in the mouth in less than 30 seconds, releasing flavor, sweetener, and tobacco.
  • HM3PA2910 (Wolff Cellulosics) 8.35 g HM100PA2208 (Wolff Cellulosics) 7.24 g HM4000PA2910 (Wolff Cellulosics) 1.21 g B700 (Grain Processing Corporation) 7.63 g Gelatin 6.11 g Tobacco Powder (average particle size ⁇ 80 ⁇ m) 15.27 g
  • a portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar.
  • the gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils.
  • the glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C.
  • the resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and cut into appropriately sized units.
  • a 1.0 inch by 1.25 inch unit of film disintegrated in the mouth in less than 30 seconds, releasing flavor, sweetener, and tobacco.
  • compositions of the invention may also be produced as tabs, such as super fast disintegrate (about 15 seconds), fast disintegrate (less than 2 minutes), slow disintegrate (2-10 minutes), and chewable tabs.
  • Tabs may be sized as individual servings or smaller, a plurality of which constitute an individual serving. Tabs sized as individual servings typically have dimensions of 5 mm to 15 mm. Smaller tabs typically range from 2 to 4 mm in diameter. Such smaller tabs may be fabricated in a variety of colors or flavors, e.g., for simultaneous consumption. Tabs may be shaped as a wafer, a convex or concave pellet, ovals, or any other shape known to the trade. Tabs may also be foamed to provide faster dissolution or disintegration in the mouth. Tabs may also be layered to provide a variety of tastes or mouth feels as the tab dissolves or disintegrates. Tabs may also be coated to modify color or taste or to provide mechanical strength for improved handling. In one embodiment, a tab designed to disintegrate rapidly in water may be coated with a very thin water insoluble coating to provide protection to the tab while a second, water soluble coating is applied.
  • Tabs may be fabricated from a dry mix, known as direct compression or from pregranulated materials by any forming method known in the art, e.g., via a press, injection molding, compression molding, injection foam molding, or compression foam molding.
  • a chewable tab can be formed using the following ingredients: compressible sugar (40%); tobacco (20%); dextrose (25%); maltodextrin (13%); coloring agents (0.05%); flavor (1.35%); and magnesium stearate (0.60%).
  • thermoplastic tab can be formed using the following ingredients (in parts): hydroxypropyl cellulose (HPC) 54; tobacco 27; microcrystalline cellulose 10; propylene glycol 4; artificial sweetener 2; flavor 2; and stabilizer 0.2.
  • the ingredients are dry mixed and fed to an extruder using barrel temperatures necessary to melt the HPC (typically 340-370° F.).
  • a rod of about 1 ⁇ 2 inch diameter is extruded and cut to size sufficient to form a tab.
  • Formulary amounts of peppermint and spearmint flavors and Na 2 CO 3 as noted in Table AB1 were added to the binding solution.
  • the entire mixture was homogenized for approximately 20 minutes at 9000-10000 RPMs with the aid of a homogenizer.
  • the proper amount of binding solution to use was determined by the batch size and the ingredient percentages shown in Table AB 1.
  • the homogenized solution was transferred into the flavor holding/pumping tank.
  • mannitol sweetener
  • tobacco powder bone dry basis
  • a Vector Multiflo-15 fluid bed coater was used to apply the binding solution to the dry ingredient blend to form the final granulation.
  • the manual process was selected on the control panel computer.
  • the machine operating parameters, located in Table AB3, were loaded into the program:
  • binding solution amount was determined by the desired batch size to achieve the ingredient percentages shown in Table AB 1.
  • the binding solution was slowly sprayed onto the dry ingredients to form the granulation.
  • the nozzle pressure was set at 22 psi and airflow at 200 CFM.
  • the airflow was increased to ensure good product movement or fluidization in the fluid bed chamber.
  • the airflow was reduced to 200 CFM. The process was stopped once the product temperature reached approximately 43° C.
  • the granulated material was then sized through a 12-mesh screen.
  • the magnesium stearate (lubricant) was sized through a 40-mesh screen.
  • the formulary amount of magnesium stearate as noted in Table AB4 was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
  • Example AB1 The procedures previously stated in Example AB1 for binding solution preparation were followed. Formulary amounts of peppermint and spearmint flavors as noted in Table AC1 and 45.00 grams of Na 2 CO 3 were added to binding solution. The remaining procedures for the make-up for the binding solution, preparation of dry ingredients, preparation of Vector Multiflo-15 Fluid Bed Chamber, and granulation process were followed.
  • the granulated material and magnesium stearate were sized through the appropriate screens as previously stated.
  • the formulary amount of magnesium stearate (0.75% for a fast disintegrate or 1.00% for a slow disintegrate) was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
  • the granulated material and magnesium stearate were sized through 12- and 40-mesh screens, respectively.
  • the formulary amount of magnesium stearate (0.50% for a fast disintegrate or 1.00% for a slow disintegrate) was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
  • Example AD The same procedures were followed for making a Tobacco Tab in Example AD except wintergreen flavor was used in place of cinnamon flavor.
  • the finished material was then sized through a 12-mesh screen.
  • the magnesium stearate was sized through a 40-mesh screen.
  • the formulary amount of magnesium stearate (0.50% for a fast disintegrate or 0.75% for a slow disintegrate) was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
  • binding solution preparation The procedures previously stated for binding solution preparation were followed. Formulary amounts of apple flavor, natural bitter blocker (Comax), and Na 2 CO 3 as noted in Table AF1 were added to binding solution. The remaining procedures for the make-up of the binding solution, preparation of dry ingredients (lactose filler plus tobacco powder), preparation of the Vector Multiflo-15 Fluid Bed Chamber, and the granulation process were followed.
  • the finished material was then sized through a 12-mesh screen.
  • the magnesium stearate was sized through a 40-mesh screen.
  • the formulary amount of magnesium stearate (0.75% for a slow disintegrate) was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
  • a 20% Opadry II aqueous solution was prepared as directed by the manufacturer and allowed to mix 45 minutes prior to coating.
  • Tabs (5.5-6.5 KG) were placed in the coating pan of a Vector/Freund Hi-Coater pan coating machine and warmed until the exhaust temperature reached 45° C. This was done with the pan running at less than 5 RPMs to minimize Tab attrition. Air at 75° C. and 100 CFM ran across the pan at a pan pressure of -0.5′′ water.
  • the pan speed was increased to approximately 15 RPMs and the Opadry coating suspension was applied at a rate of 15-20 grams/minute.
  • the suspension was continually mixed during application to prevent the solids from settling.
  • the spray was atomized with approximately 100 liters of air per minute at approximately 70 psi.
  • the atomized spray was formed into a pattern using directional air ports on the nozzle set at approximately 50 liters of air per minute at approximately 70 psi.
  • Inlet air temperature was periodically increased or decreased to maintain an exhaust temperature between 43 and 46° C.
  • Spraying was continued until desired amount of solids was applied to satisfy formulary requirements which was typically around 3%, or until tabs were visually satisfactory.
  • Klucel EF Hercules
  • Water portion 2 (cold) was placed in an ice bath to chill while water portion 1 (hot) was heated to 60° C. and transferred to a stainless steel container. The 60° C. water was stirred with an Arrow Model 1750 high shear mixer and the Klucel EF gradually added to the water. This solution was stirred for several minutes. Water portion 2 (cold) was then added to the mixture. An ice bath was placed under the stainless steel container, and the mixture was stirred for 15 minutes.
  • the remaining ingredients were added to the mixture one at a time.
  • the mixture was thoroughly blended prior to the addition of the next ingredient.
  • the ingredients were added in the following order: tobacco flavor modifier, propylene glycol, sucralose solution, corn syrup, sodium carbonate solution, sucrose, tobacco powder, B700, and oil of peppermint. Ice was added to the ice bath throughout the mixing process to keep the mixture cold. After all ingredients were added, the mixture was stirred for an additional 10 minutes.
  • the container was removed from the ice bath and the mixture was dispensed in solid disintegratable portions onto wax paper and allowed to dry at room temperature for 24 hours.
  • the solid disintegratables were removed from the wax paper and transferred to another sheet of wax paper to continue drying at room temperature.
  • the desired hardness for the solid disintegratables was achieved after 12 to 24 hours of continued drying.
  • Water portion 1 (hot) was heated to 80° C. and transferred to a stainless steel container.
  • the 80° C. water was stirred with an Arrow Model 1750 high shear mixer, and the HPMC gradually added to the water. This solution was stirred for several minutes.
  • Water portion 2 (room temp.) was then added to the mixture, and the mixture was stirred for 15 minutes.
  • the remaining ingredients were added to the mixture one at a time.
  • the mixture was thoroughly blended prior to the addition of the next ingredient.
  • the ingredients were added in the following order: tobacco flavor modifier, propylene glycol, sucralose solution, corn syrup, sodium carbonate solution, sucrose, tobacco powder, B700, and oil of peppermint. After all ingredients were added, the mixture was stirred for an additional 10 minutes.
  • the mixture was dispensed in portions onto wax paper and allowed to dry at room temperature for 24 hours.
  • the solid disintegratables were removed from the wax paper and transferred to another sheet of wax paper to continue drying at room temperature.
  • the desired hardness for the solid disintegratables was achieved after 12 to 24 hours of continued drying.
  • composition of these layers can be the same or different in composition.
  • Individual layers can be differentiated by color, flavor, tobacco type, tobacco content, dissolution rate, and other similar characteristics. For example, one layer could disintegrate very rapidly to release flavor or flavor masking ingredients. A second layer containing tobacco powder could disintegrate more slowly thereby gradually exposing the tobacco.
  • Tobacco compositions may also be formed into products that are sufficiently rigid to be easily handled. These shaped products may vary in physical properties and range from highly flexible to highly stiff parts. Such products may be formed into any shape and be dense or foamed. These compositions typically have a moisture content of 2-50%, preferably 5-10%, of the finished part weight. Exemplary shapes include a tube, a toothpick, a stick, a twist, or a solid rod. Typically, a shaped part will be sucked or chewed on for an extended period of time to release tobacco organoleptic components into the mouth. A shaped part may or may not disintegrate orally. Parts that disintegrate may do so over a period of 1-60 minutes, preferably from 1-10 minutes.
  • Shaped parts may or may not be sized to fit entirely in the mouth. Compositions larger than the mouth may be partially inserted. Typically the largest dimension of a shaped part is 6 inches, more preferably 2.5 inches.
  • Shaped parts may contain discrete regions, e.g., with each region having the same or different flavor or color or size or form of tobacco, e.g., tobacco perceived as soluble.
  • a twist may contain individual strands, each having a different flavor or color or size or form of tobacco.
  • shaped parts may be prepared in multistep processes in which molded or extruded parts are composed of layers, two or more of which contain different flavors, colors, or sizes or forms of tobacco.
  • Shaped part compositions may be fabricated by any method known in the art, e.g., extrusion, compression molding, injection molding, impact forming, foam molding, blow molding, and overmolding.
  • shaped parts may be based on water soluble or thermoplastic formats.
  • an aqueous-based shaped part is fabricated by forming a viscous paste (e.g., via Hobart process) of the format, water, tobacco, and other ingredients and pressing the paste into a form, extruding through a die, or forming a sheet from which shapes are cut.
  • the cut or formed part may then be dried to the desired moisture level of from 2-50%, preferably from 5-10% of the finished part weight for very rigid parts and from 10-50% for highly flexible parts.
  • the aqueous paste can be formed in a two stage extrusion process (e.g., via a Wenger twin screw extruder) in which the format, water, tobacco, and other ingredients are blended in a mixing or pre-extrusion stage of the machine, and the resulting paste is fed directly to the twin screw extrusion element of the machine and is extruded through a die to form a shape, which is then dried to the desired moisture level.
  • a thermoplastic-based shaped part is fabricated, for example, by mixing components via a PK blender, high intensity mixer, pre-pelletizer, or granulation (fluid bed or Hobart) process. The mixed components may then be extruded through conventional single or twin screw extruders to form shaped parts or the mixture can be fed into injection molding machines or other thermoplastic processing machinery to form shaped parts.
  • the following table provides exemplary shaped parts to be formed by injection molding.
  • Heating zones were Zone 1—300-340° F.; Zone 2—350-370° F.; Zone 3—300-340° F.; mold temperature was ambient. Sufficient composition was fed to the screw to equal one injection cycle; the material was immediately injected into the mold; the mold was opened after 10 seconds; and the part was removed.
  • the shaped part was a stepped color chip, 2 inches by 3 inches by steps at 1 ⁇ 8 th , 1 ⁇ 4 th , and 3 ⁇ 8 th inch thickness.
  • the following table provides exemplary shaped parts formed by compression molding.
  • Additives may also be employed so that the shaped part remains flexible after removal from the tool.
  • the parts containing a majority of low viscosity HPC formed excellent pieces if left in the tool for an extended time (40 to 60 seconds).
  • the inclusion of plasticizer increased the rate of moisture absorption from the atmosphere, which caused some parts to soften over time.
  • Foaming can be accomplished in aqueous systems by incorporating a surface active agent (e.g., sodium lauryl sulfate) into the mix and beating to incorporate air; foaming or aeration can also be achieved by introducing a gas (e.g. nitrogen) to the aqueous system while the composition is under high shear. The aqueous system is then dried to the desired moisture level to create a stable foamed composition.
  • a surface active agent e.g., sodium lauryl sulfate
  • a gas e.g. nitrogen
  • an aqueous composition is introduced to partially fill a compression mold; the mold is closed; the mold temperature is raised above the boiling point of water to form steam, which expands the aqueous composition to fill the void area and to create a foamed, shaped part.
  • foaming can be accomplished by incorporating water into the tobacco/format composition; the temperature is raised to above the boiling point of water to form steam; and, as the tobacco composition exits a die, the steam expands to create a foamed structure.
  • gas e.g., nitrogen or carbon dioxide
  • thermoplastic foaming processes well known in the art e.g., injection foam molding
  • Tables AL1 and AL2 show exemplary ingredients for fabricating aqueous shaped parts of the invention. Sufficient water is added to form a viscous paste.
  • Example Tobacco 1-80 30-50 54 Flavor 0.5-4 2.5-3 3 Insoluble Fiber 4.5-36 22.5-27 27 Water Soluble 1-50 5-20 10 CMC 7MF Polymer (medium viscosity) Filler/Disintegrant 1-50 10-30 30 microcrystalline cellulose Artificial Sweetener 0.05-5 0.1-2 0.2 Sucralose Dispersant 0.1-20 0.1-2 0.2 Sodium Lauryl Sulfate
  • Example Tobacco 1-80 20-50 27 Flavor 0.5-4 1-3 1 Insoluble Fiber 4.5-36 9-27 9 Water Soluble Polymer 1-50 5-25 18 low viscosity HPC Filler/Disintegrant 1-50 10-30 10 microcrystalline cellulose Artificial Sweetener 0.05-3 0.1-1 0.5 Sucralose Dispersant 0.1-20 0.1-2 0.2 sodium lauryl sulfate
  • Table AM1 shows exemplary ingredients for fabricating thermoplastic shaped parts of the invention.
  • a tobacco rod is made from tobacco (54 parts); flavor (2); insoluble fiber (28); CMC (10); artificial sweetener (0.2); and microcrystalline cellulose (30).
  • Water sufficient to form a viscous paste e.g., 140 parts
  • a suitable extruder would be a Kitchen Aid mixer fitted with a pasta extruder and die. The rod prepared from extrusion through a pasta die can then be used as the forming mandrel for a spiral winding machine and a tobacco containing film can be used to form a wrapping around the tobacco core.
  • MIX1 HM100PA2208 (Wolff Cellulosics) 11.16 g B700 (Grain Processing Corporation) 55.77 g Cinnamon Powder 24.54 g Fibersol-2 (Matsutani) 44.61 g Na 2 CO 3 6.69 g Sucralose (Tate & Lyle) 2.22 g Tobacco Powder (average particle size ⁇ 80 ⁇ m) 55.77 g
  • MIX1 was added to the stainless steel mixing bowl of a Kitchen Aid stand mixer. MIX2 was incorporated slowly to the mixture over a time period of 3 minutes with the aid of a paddle attachment at a medium-low speed. Following this addition, 76.92 g of water was added to the mix in the same manner. The resulting paste was allowed to rest at room temperature for a period of 5 minutes.
  • the paste was fed through a 1 ⁇ 8 inch aperture strand forming unit which had previously been attached to the Kitchen Aid mixer.
  • the strands produced were cut to between 11 ⁇ 2 and 2 inches in length, and stored in suitable containers.
  • a set of platens with 2 inch by 1 ⁇ 4 inch opposing mold cavities was heated to between 300-330° F.
  • a formed strand was placed in the lower cavity, and the mold was closed by means of a hydraulic press.
  • the mold was allowed to remain closed for a period of 30-60 seconds, providing a means for cooking the starch component of the unit and the release of a portion of the volatile components.
  • the newly formed stick measuring approximately 2 inches by 1 ⁇ 8 inch, comprised a smooth rigid outer layer, and a rigid foam-like inner mass.
  • the unit disintegrated in the mouth over a period of 1-2 minutes.
  • MIX1 HM100PA2208 Wilff Cellulosics 11.16 g B700 (Grain Processing Corporation) 55.77 g Sucrose 22.29 g Fibersol-2 (Matsutani) 44.61 g Na 2 CO 3 6.69 g Sucralose (Tate & Lyle) 1.11 g Malic Acid 2.22 g Tobacco Powder (average particle size ⁇ 80 ⁇ m) 55.77 g
  • MIX1 was added to the stainless steel mixing bowl of a Kitchen Aid stand mixer. MIX2 was incorporated slowly to the mixture over a time period of 3 minutes with the aid of a paddle attachment at a medium-low speed. Following this addition, 76.95 g of water was added to the mix in the same manner. The resulting paste was allowed to rest at room temperature for a period of 5 minutes.
  • the paste was fed through a 1 ⁇ 8 inch aperture strand forming unit which had previously been attached to the Kitchen Aid mixer.
  • the strands produced were cut to between 11 ⁇ 2 and 2 inches in length, and stored in suitable containers.
  • a set of platens with 2 inch by 1 ⁇ 4 inch opposing mold cavities was heated to between 300-330° F.
  • a formed strand was placed in the lower cavity, and the mold was closed by means of a hydraulic press.
  • the mold was allowed to remain closed for a period of 30-60 seconds, providing a means for cooking the starch and sugar components of the unit and the release of a portion of the volatile components.
  • the newly formed stick measuring approximately 2 inches by 1 ⁇ 8 inch, comprised a rigid outer layer, and a rigid foam-like inner mass.
  • the unit disintegrated in the mouth over a period of 1-2 minutes.
  • the tobacco granulation was introduced to the feed section of a Leistritz Micro-18 Twin Screw Extruder 40:1 L/D, which had been configured for co-rotating extrusion with a medium-shear screw design.
  • Feed rates for the extrusion varied between 1-3 pounds per hour.
  • Barrel zone temperatures varied between 75-100° F.
  • Flavor application rates were established at 5 percent of the process flow; hence cinnamon flavor was incorporated to the process downstream of the granulation feed. Venting of volatiles from the extrusion melt was accomplished by incorporating a venting orifice prior to the discharge die of the extruder.
  • Solid tobacco sticks with an approximate diameter of 1 ⁇ 8 inch, were produced by incorporating a strand die at the discharge end of the extruder. Upon discharge, the flexible tobacco strand was cooled to room temperature on an air-cooling conveyor and became rigid, and was cut to approximately 21 ⁇ 2 inches in length. The formed tobacco sticks were placed in a suitable container for storage. The stick disintegrated slowly in the mouth over a period of 5-10 minutes.
  • compositions of the invention may also be made as gels or gel beads.
  • the composition may contain a soluble or insoluble gel containing tobacco.
  • a gel may be used to encapsulate another material, or another material may encapsulate a gel.
  • Gels may be consumed in hydrated forms containing as much as 70% water.
  • the gels may also be dried resulting in parts containing from 1 to 70% water. The amount of water retained in the gel depends on the properties desired in the finished product. It is possible to prepare tobacco containing gels that provide a wide range of organoleptic characteristics.
  • Exemplary gel formats for soluble and insoluble gels include kappa carrageenan, sodium alginate, carboxymethyl cellulose, gelatin, pectin, agar, and starches.
  • Soluble gels containing tobacco can be formed by dissolving the format and at an elevated temperature, e.g., kappa carrageenan at 180° F., and adding the tobacco powder to this solution while continuing vigorous mixing. The hot mixture is then deposited into a mold.
  • Gelatin provides a weak gel at room temperature but firmness and stability can be increased by the addition of agar or starches.
  • Other gelling formats may be used in a similar manner.
  • Insoluble gels are formed by the addition of a cross-linking agent to a predissolved solution or slurry.
  • the solution is deposited into a mold to form the desired shape and sets up through cooling and/or drying. In most cases, it is necessary to maintain the solution at a high temperature, e.g., greater than 180° F., to prevent premature gelation prior to deposition into the mold.
  • the gel can be packaged as is or be further dried to a desired water content.
  • Cross-linking agents include potassium ions for carrageenan; calcium ions for alginates and low methoxy pectins; and trivalent ions such as aluminum for carboxymethyl cellulose.
  • tobacco organoleptic compounds may leach out of the gel as it is held or chewed in the mouth.
  • gel compositions e.g., beads
  • An exemplary solid center includes smokeless tobacco.
  • An interior liquid may be aqueous, non-aqueous, or heterogeneous, depending on the solubility characteristics of the encapsulating bead wall.
  • Aqueous based liquids are typically encapsulated in a water-insoluble gel that can be disrupted, either mechanically or chemically, in the mouth.
  • the encapsulating gel format may include a polymer and a cross linking agent.
  • Exemplary systems include carrageenan and a monovalent cation (e.g. potassium), alginate or pectin and a divalent ion (e.g. calcium), carboxymethyl cellulose and a trivalent ion (e.g. aluminum), and gelatin and gum arabic.
  • the center may or may not include tobacco.
  • a water soluble gel encapsulates a non-aqueous filling, e.g., employing ethanol, glycol, vegetable oil, or mineral oil.
  • the water soluble gel and/or the non-aqueous filling may contain tobacco and other ingredients as described herein.
  • Aqueous liquids may also be encapsulated in water soluble gels by the inclusion of additives, e.g., sugars or salts, that sufficiently bind the available water in the filling, thus, preventing the water in the liquid from dissolving the encapsulant.
  • Gel encapsulants also include both hard and soft standard gelatin capsules, which can be filled with liquids or solids.
  • the center of these gel compositions may or may not include tobacco, e.g., as a tobacco slurry.
  • the gel encapsulant also may or may not include tobacco.
  • An exemplary solid center includes smokeless tobacco.
  • the center may also include a color, sweetener, flavor, or flavor masking agent, which may be the same or different from that of the gel encapsulant.
  • the rate of disintegration for the gel encapsulant and center may also be the same or different.
  • Gels with centers typically have a largest dimension of at most 10 mm, e.g., at most 5 mm.
  • Gel beads with liquid centers may be made by introducing droplets of a tobacco/format mixture into a solution causing gelation of the outer surface of the gel bead and retaining the liquid center.
  • Beads can be formed using commercial processes developed by the Morishita Jintan Company and others and referred to generically as “seamless liquid encapsulation” or “seamless capsule technology.”
  • widely used methods for forming gels of all types including beads have been developed by the suppliers of alginate, carrageenan, and pectin polymers and are well known in the art.
  • the amount of gelation may be controlled, thereby controlling the thickness of the gel encapsulant wall, by varying the concentration of the format, the concentration of the cross-linking agent (e.g., salt), the temperature of the solidifying solution, and the residence time of the gel bead in the solidifying solution.
  • the solution may contain a cross-linking agent or may induce gelation by other means, e.g., a temperature change.
  • Solid gels may be soluble or insoluble.
  • the tobacco and format, with or without additives are typically mixed, and the format is allowed to gel.
  • Soluble gels can be obtained by using a self gelling gum, such as gellan gum or kappa carrageenan, or by using a polymer, e.g., gelatin, that sets by a change of temperature.
  • Insoluble solid gels are prepared using a cross linking agent.
  • Such soluble and insoluble gels may be made by introducing droplets into an oil bath, e.g., canola oil, or into an aqueous, cross-linking bath to form a spherical shape. They may also be made to pass through the oil into a water based cross-linking solution. Gels may also be made in molds or may be die cut from sheets.
  • a gel composition is supplied as a dry mixture of format, cross-linking agent (e.g., salt), and tobacco, e.g., in powder form, that is solvated by the consumer prior to use.
  • Solvation causes the gel composition to form a solid, which may be placed in the mouth.
  • the user places the dry mixture of gel ingredients in a mold and adds solvent, which may be aqueous or non-aqueous. The mixture then quickly hydrates, thereby forming a gel which solidifies in the shape of the mold.
  • the solvating liquid may be used to impart flavor or other taste or mouth feel characteristics to the composition.
  • the consumer may place the dry mixture in the mouth for salvation.
  • the solvent may impart flavor or color to the composition.
  • 100 g of 4% solution of CMC-7MF and 20 g tobacco are combined. Drops are deposited into a 5% solution of water soluble, edible trivalent salt (e.g., AlCl 3 or Al 2 (SO 4 ) 3 ). The surface of droplets is then dried with air drying or gentle oven drying. 100 g of 2% kappa carrageenan and tobacco are combined and heated to 180-190° F. Drops are deposited into a cool solution of 5% KCl. 100 g of 4% medium viscosity sodium alginate and tobacco are combined at 150-170° F. Drops are deposited into a cool solution of 5% edible divalent salt (e.g., CaCl 2 or Ca citrate).
  • water soluble, edible trivalent salt e.g., AlCl 3 or Al 2 (SO 4 ) 3
  • the surface of droplets is then dried with air drying or gentle oven drying.
  • 100 g of 2% kappa carrageenan and tobacco are combined and heated to 180-190° F
  • Beads containing gelatin walls and tobacco slurry centers can be prepared by depositing drops of a cold tobacco slurry (e.g. 60° F.) into a slow moving stream of a dilute, warm gelatin solution (e.g. 130° F.).
  • the warm gelatin coats the outside of the cold droplet and as the gelatin cools and solidifies, it forms a wall of gelatin around the liquid center.
  • Beads are retrieved from the solution by standard means.
  • Table AS1 shows exemplary ingredients for fabricating orally disintegrable gels of the invention.
  • Example 1 (parts)
  • Example 2 (parts) Gelatin 8 6 Tobacco 40 40
  • Flavor 2 2
  • Insoluble Fiber 18 18
  • Agar 4 6
  • Soluble Fiber 15 15
  • composition is cast at 180° F. after adding KCl and mixing thoroughly.
  • composition is cast after adding CaCl 2 at 180° F.
  • composition is cast after adding Al2(SO 4 )3 at 180° F.
  • the resulting mixture was quickly transferred via pipette (inner diameter 0.5 cm) to Teflon-coated metal molds to obtain the desired shape. After cooling to room temperature, the resulting gels were removed from the molds and air dried at room temperature for 1 h to several days until the desired consistency of the gels was obtained.
  • the resulting mixture was transferred via pipette (inner diameter 0.5 cm) to Teflon-coated metal molds to obtain the desired shape. After cooling to room temperature, the resulting gels were removed from the molds, and the gelatin was set by refrigeration at 40° F. for 1 hour to several days depending on desired firmness of the finished piece.
  • a solution of 4% sodium alginate (Keltone LV, International Specialty Products) was prepared by adding 12 g sodium alginate to 288 g of water heated to boiling, followed by stirring and continuous heating of water on a hot plate for 30 minutes or until the solution was homogeneous (stock solution A).
  • a second solution of 0.50 M disodium hydrogen phosphate was prepared by dissolving 33.5 g disodium hydrogen phosphate heptahydrate in 200 ml of water with warming and stirring of the resulting mixture until the salt was dissolved, followed by adjusting the solution to 250 ml with water.
  • To 100 g of aqueous 0.50 M disodium phosphate was added 20 grams of tobacco and the resulting solution was stirred for 5 minutes (stock solution B).
  • a solution of aqueous 5% CaCl 2 was prepared by adding 5 g of CaCl 2 to 95 g of water with stirring until the calcium chloride was dissolved (solution D).
  • Solution C was then added drop by drop to solution D by pipette from a height of 10 inches.
  • the outer coat of each droplet solidified upon exposure to solution D, forming a solid gel-like outer coat with a liquid center that sank to the bottom of the calcium chloride solution.
  • the gel beads were allowed to remain in the calcium chloride solution for 2-4 minutes, removed, and allowed to air dry for several minutes.
  • Solution B Amount parts Disodium hydrogen phosphate heptahydrate 13.4 Water 86 Tobacco 20
  • Solution C Amount parts Solution A 50 Solution B 50 Sucralose 0.2 Oil of peppermint 0.8
  • compositions of the invention may also be fabricated as consumable units. These units may be packaged as edible or inedible materials.
  • the consumable unit includes tobacco (e.g., smokeless tobacco) or a tobacco composition, e.g., flakes, tabs, beads, granules, or other tobacco composition as described herein, and a wrapping, e.g., a pouch.
  • the wrapping in one embodiment, may act as an adhesive to hold the composition together, e.g., to hold a plurality of tabs, beads, flakes, etc. together.
  • the wrapping may enclose the composition, e.g., loose tabs, beads, flakes, etc.
  • the composition may also include a liquid, e.g., a tobacco slurry.
  • the wrapping may or may not be orally disintegrable. Orally disintegrable wrappings may be used to enclose aqueous or non-aqueous liquids.
  • the liquid includes an agent to prevent dissolution of the wrapping.
  • agents include sugars, salts, and other hydrophilic agents capable of binding water sufficiently to reduce water activity to a level at which the water is no longer available to interact with and dissolve the water soluble wrapping.
  • the wrapping may also enclose a moldable tobacco composition that conforms to the mouth or holds its shape in the mouth.
  • an orally disintegrable wrapping encloses smokeless tobacco, e.g., dry snuff or tobacco, that is perceived as soluble (e.g., less than 80 .mu.m particle size).
  • Orally disintegrable smokeless tobacco compositions may be introduced to consumable portion packs which have been formed on continuous thermoforming or horizontal form/fill/seal equipment or other suitable packaging equipment using edible films (which may or may not contain tobacco) made in accordance with the subject technology.
  • Consumable units may also contain two or more, individually wrapped portions of tobacco, e.g., all contained within a larger package, one containing the other portions, or none of the portions contained with another. When multiple portions are used, any two may have the same or different flavor, color, form of tobacco, or rate of disintegration.
  • Exemplary wrapping materials include films formed from film compositions based on formats such as HPMC, CMC, pectin, alginates, pullulan, and other commercially viable, edible film forming polymers, such as those described herein.
  • Other wrapping materials may include pre-formed capsules made from gelatin, HPMC, starch/carrageenan, or other commercially available materials.
  • Such wrapping materials may include tobacco as an ingredient.
  • Wrappings which are not orally disintegrable may include woven or nonwoven fabrics; coated or uncoated paper; or of perforated or otherwise porous plastic films. Wrappings may also be colored.
  • Exemplary consumable units include those formed by any method used in commercial packaging, e.g., blister pack and stik-pak (e.g. a small package formed on a vertical form/fill/seal packaging machine).
  • compositions described herein can be encapsulated with a film or capsule.
  • the encapsulant may provide color, stability (e.g., during storage, handling or consumption), or organoleptic properties (e.g., flavor, sweetness, smell, or mouth feel).
  • the encapsulant may also contain tobacco.
  • a vacuum forming tool is constructed which has a series of cavities which are shaped as circles with diameter of 3 ⁇ 4 th inch and depth of 33 ⁇ 8 th inch.
  • Films as described herein are prepared with and without tobacco as an ingredient. These films are introduced to a vacuum forming machine with a vacuum forming tool. The films are placed over heating elements and warmed to a temperature of 200° F. The films are then quickly placed on the vacuum forming tool, and a vacuum is pulled to draw the film into the cavities. The films are then cooled to set the shapes. Tobacco powder is then introduced into each cavity. A second sheet of film prepared with or without tobacco is selected and coated (by wiping the surface of the film with a wet felt) with a thin layer of water to create a sticky, adhesive surface.
  • each cavity is filled with a tobacco product.
  • the sheets are pressed together to form closed consumable units.
  • Each cavity is then cut out of the vacuum formed sheet to create individual units.
  • a unit is placed in the mouth wherein the film disintegrates and disperses the tobacco in the oral cavity.
  • Smokeless tobacco particles or powder may be placed in a water-disintegrable bag. When placed in the mouth, the bag disintegrates after a specified period of time.
  • the bag may contain a single serving of tobacco. It may also contain additional additives as described herein.
  • the tobacco may also adhere to itself as a moldable plug once the wrapping disintegrates.
  • the disintegrable bag may be formed using films such as those described herein.
  • the film can be formed into a bag using commercially available packaging equipment such as vertical form/fill/seal machines (e.g. stick pack machines), horizontal form/fill/seal machines, flow wrappers, thermoformers (blister pack machines), and other equipment common to the art.
  • Smokeless tobacco particles or powder may be placed in a bag that is formed from an open or highly porous wrapping material, e.g., fabrics, paper or plastic films, which has been laminated to a water-soluble wrapping film.
  • the water-soluble film layer provides protection for the tobacco contents and prevents the tobacco from sifting through the openings of the insoluble material during storage and handling. Once the bag is placed in the mouth, the water-soluble film layer dissolves or disintegrates.
  • Films as described herein in Film Examples N, O, P, and Q were used to manufacture tobacco containing pouches. Individual units approximately 1 inch by 11 ⁇ 4 inches were cut from each sheet of manufactured film. The unit was folded over lengthwise and heat-sealed using a Clamco Model 210-8E impulse sealer. One end of the formed unit was also sealed in the same manner. A flavored tobacco granulation was fed to the interior of the formed pouch, and the final seal was made as described to seal the pouch. The tobacco containing pouch disintegrated in the mouth between 20 seconds and 1 minute, releasing the contents of the pouch.
  • Tobacco may also be coated onto or entrapped within an insoluble matrix.
  • Tobacco can be dispersed to form a slurry in an aqueous solution of a format, as when forming a film; this slurry can be coated on to an insoluble matrix or can be used to saturate a porous insoluble matrix.
  • the slurry may then be converted into a soluble or insoluble gel or it may simply be dried to form a coating.
  • leaching of organoleptic components occurs through dissolution, chewing, or other means.
  • tobacco in a format is introduced into a porous matrix, e.g., an open.
  • insoluble matrix may be placed wholly in the mouth, or it may be disposed on a stick or other handle, which remains partially outside the mouth during consumption.
  • tobacco in a format is blended with an incompatible liquid, e.g., a dispersion of carnauba wax in water, deposited in a mold, and quickly cooled to cause a phase separation such that the tobacco slurry is disposed within a waxy structure.
  • an incompatible liquid e.g., a dispersion of carnauba wax in water, deposited in a mold, and quickly cooled to cause a phase separation such that the tobacco slurry is disposed within a waxy structure.
  • Formats for use in retaining the tobacco in the insoluble matrix include any of the film forming polymers described herein; any of the gelling systems described herein and any of the coating materials described herein.
  • a film forming composition which contains finely ground tobacco as described herein is used to saturate a piece (e.g., 12 inches by 12 inches by 1 inch) of open cell polyurethane foam (Stephenson & Lawyer, Inc. Grand Rapids, Mich.).
  • the saturated foam is placed on a metal tray and is put into an air circulating laboratory oven preset at 175° F. for one hour.
  • the tobacco containing composition has dried to form a coating that uniformly covers all the interstices of the polyurethane foam.
  • the coated foam is cut into pieces of a size (e.g., 1 inch by 1 inch by 1 inch) suitable to place in the mouth. After use, the polyurethane foam is removed from the mouth and discarded.
  • a sodium alginate and calcium salt gel composition containing finely ground tobacco as described herein is used to saturate an open cell polyurethane foam (e.g., 12 inches by 12 inches by 1 inch).
  • the alginate gel is maintained at a temperature of 180° F. to prevent premature setting of the gel.
  • the hot alginate gel is poured on to the polyurethane foam, which is placed on a metal tray and then quickly cooled in a refrigerator at 40° F. to set the gel.
  • the foam is then placed in a laboratory oven preset at 175° F. for 10 minutes to surface dry the gel and to reduce moisture content to 50% based on dry weight of the gel.
  • the partially dried gel fills voids in the polyurethane foam.
  • the foam is cut into pieces and is placed in the mouth.
  • a further example of gels in an insoluble matrix is obtained by drying the gel to a lower moisture content (e.g., 10% based on dry weight of the gel).
  • the tobacco containing gel exhibits a firm, rubbery texture within the foam matrix and rehydrates slowly when placed in the mouth and chewed. After use, the polyurethane foam is removed from the mouth and discarded.
  • Hollow Shapes As discussed above, films or thin sheets of material may be wrapped, extruded, blow molded, or otherwise shaped to form tubes, straws, or other hollow shapes. Exemplary film or sheet materials are disclosed in the film section herein. Such hollow shapes may be single or multilayer. When multiple layers are used, some may contain tobacco while others may contain colors, flavors, sweeteners, or other compounds as described herein. Different layers may also be employed for stability during handling or to control disintegration during consumption. A spiral wrapped hollow shape, e.g., tube or straw, may require an adhesive (e.g., CMC or guar) to keep from unraveling. The layers in a multilayer hollow shape may contain the same or different color or flavor, and such layers may disintegrate at the same or different rates. As with films, tobacco may also be disposed within one or more layers or may be disposed between layers in a sandwich arrangement. The hollow shape may also include a disintegrant to hasten disintegration.
  • an adhesive e.g., CMC or guar
  • compositions described above may be hollow or filled.
  • the filling may include tobacco, a flavor, sweetener, flavor masking agent, or a color.
  • the flavor or color of the filling may be the same or different than the hollow shape.
  • the filling is typically a gel (solid or flowable) but may also be mechanically rigid or may be composed of a powder or other product form.
  • Exemplary filling materials include gels as described herein.
  • a hollow shape may also be filled with a composition that disintegrates more rapidly than the shape, e.g., to provide tobacco at different times based on the rate of disintegration.
  • a tobacco core e.g., formulated with tobacco and a format
  • a water soluble, thermoplastic outer layer e.g., formulated with a format and a flavor
  • HPC hydroxypropyl cellulose
  • a rigid extruded tobacco rod may become a core which is encased in a wrapped film.
  • thermoplastic formulation containing hydroxypropyl cellulose, tobacco, flavor, and sweetener can be blow molded to form a hollow shape.
  • films as described herein were additionally used to manufacture spiral-wound straws and/or sticks. Strips of film approximately 10 inches by 3 ⁇ 4 inch were cut from each sheet of manufactured film. A strip of paper of equal size was cut and wound spirally around a 3/16 inch diameter stainless steel mandrel. The paper was secured about the mandrel with tape on each end. A strip of film was wound spirally about the paper in the same fashion, overlapping each spiral by 1/16 inch. At each overlap the film strip was glued to itself with a 30% solution of gum arabic. The process was repeated with two additional plies of film. The mandrel and newly formed spiral-wound film straw/stick was placed in a side-swept forced air oven at 75° C.
  • spiral-wound straw/stick products were prepared using tobacco containing films as described in Example N. Flavored Tobacco Film for Sticks/Wraps/Pouches/Vacuum Forming. Straw/stick products containing one layer, two layers and three layers of Example N films were prepared as described. When placed in the mouth, the straw/stick disintegrated gradually over a period of 1 to 5 minutes.
  • straw/stick products were prepared using two layers of film as described in Example N.
  • a third layer of film prepared as described in Example O. Flavored/Colored Film for Sticks/Wraps/Pouches, was provided on the top or outside of the straw/stick.
  • the film from Example O was red in color, cinnamon flavored and did not contain tobacco. This straw/stick, when placed in the mouth, disintegrated gradually over a period of 1 to 5 minutes
  • straw/stick products were prepared using three layers of film as described in Example P.
  • Peach Flavored Film for Sticks/Wraps/Pouches The film from Example P contained tobacco powder and peach puree.
  • the straw/stick was prepared as above. The straw/stick disintegrated gradually over a period of 1 to 5 minutes.
  • straw/stick products were prepared using three layers of film as described in Example N and Example Q.
  • One layer of tobacco containing film prepared in Example N was used.
  • a second layer of opaque, white film prepared as in Example Q was wound over the first layer of film and offset by 1 ⁇ 8 th inch.
  • a third layer of tobacco containing film as prepared in Example N was wound over the second layer and again was offset by 1 ⁇ 8 th inch. The affect was to provide a spiral-wound straw/stick with a striped appearance.
  • the straw/stick when placed in the mouth, disintegrated gradually over a period of 1 to 5 minutes.
  • hollow tobacco straws with diameters ranging from 1 ⁇ 8 to 1 ⁇ 4 inch, were produced by methods similar to those employed in Example AQ of Shaped Parts; however, a tube die was employed in the manufacture of the straw. The straw(s) disintegrated slowly in the mouth over a period of 5-10 minutes. Similar articles may be manufactured with a filling, with methods known in the art (i.e. co-extrusion).
  • any tobacco composition described herein may be modified in various ways.
  • a composition may be coated in single or multiple layers. Such coatings are employed, e.g., for handling, disintegration rate, taste, and color.
  • Exemplary coatings include HPMC.
  • Coatings or decorative patterns may be applied to the surface of the film using processes known in the art, e.g., spraying, brushing, roll coating, doctor bar casting, slot coating, extrusion coating, hot melt deposition, depositing particles or flakes, and other typical methods. Coatings may be matte or glossy.
  • a coating may contain a color, flavor, sweetener, or flavor masking agent, as described herein. The color, flavor, sweetener, or flavor masking agent in the coating may be same or different as the underlying composition.
  • multiple coatings may also contain the same or different color, flavor, sweetener, or flavor masking agent.
  • the coating may also disintegrate at a different rate than the underlying composition. For example, a coating may disintegrate faster than the underlying composition to provide a burst of flavor or other organoleptic components.
  • An orally disintegrable coating may also be placed on a composition that does not disintegrate orally.
  • a coating that does not disintegrate orally may be placed on a composition that disintegrates orally, and such a coating may be removed, e.g., by chewing.
  • Coatings may also be employed to prevent evaporation of volatile components in a composition and to prevent mechanical maceration of a composition prior to use.
  • a coating may also contain tobacco.
  • Patterns may also be printed on the surfaces of compositions. Printing patterns also encompasses dusting or sprinkling compounds on the surface of a composition.
  • the pattern may be random or in a design, e.g., a logo. All printing processes known in the art, e.g., offset, flexographic, gravure, ink jet, laser, screen printing, and other typical methods may be used.
  • the printed pattern may or may not contain a color, flavor, sweetener, or flavor masking agent, as described herein.
  • the color, flavor, sweetener, or flavor masking agent in the pattern may be same as or different from the underlying composition.
  • multiple patterns may also contain the same or different color, flavor, sweetener, or flavor masking agent.
  • the printed pattern may also contain tobacco, e.g., up to 1-99%, preferably 10-50%. Such a pattern may contain more tobacco, percentage-wise or in an absolute sense, than the underlying composition.
  • Flakes may also be added to compositions described herein. Flakes may be mixed into the composition, may be placed within a void in the composition, or may be placed on the surface, e.g., and adhered by a coating. Flakes may or may not contain a color, flavor, sweetener, or flavor masking agent, as described herein. The color, flavor, sweetener, or flavor masking agent in the flakes may be same or different as the underlying composition. In addition, multiple flakes may also contain the same or different color, flavor, sweetener, or flavor masking agent. Flakes may also contain tobacco, e.g., up to 99%, preferably up to 50%. Flakes may be made by standard film forming technology as described herein. Flakes may contain more tobacco, percentage-wise or in an absolute sense, than the underlying composition.
  • an additional layer of film may be applied to cover, protect and seal the printed, coated or decorated surface.
  • compositions of the invention may be shaped in various forms, e.g., plants and geometric shapes (e.g., round, square, rectangular, triangular, oval, octagonal, and the like).
  • compositions may contain a pattern in relief (positive or negative) on the surface.
  • a pattern may be a design, such as a logo.
  • Composite compositions i.e., compositions including two or more of the different types of products described herein, are also contemplated by the invention.
  • a shaped part may contain regions of gel compositions, e.g., having a variety of flavors.
  • a tab may be surrounded by a gel.
  • Composite compositions may also have different rates of disintegration.
  • compositions will be packaged as appropriate for the contents of the composition.
  • the compositions are stored in a waterproof case and are stable between 40 and 120° F.
  • Compositions are typically dry, flexible, and non-adhesive while in storage.
  • compositions may be packaged using non-stick barriers, e.g., plastic film or paper, between servings.
  • Compositions may also be provided in a bulk form, from which individual servings are separated.
  • the package is water impermeable and water insoluble, and tobacco, e.g., in liquid, slurry, or flowable gel form, is disposed within the package, e.g., a squeezable plastic package, a bellows, or a spray bottle, and is capable of being dispensed into the mouth from the package.
  • the bellows may be compressed for oral use. Solutions or slurries are prepared for use in a plastic bellows container or other similar consumer packaging containers wherein the liquid is injected into the mouth by squeezing the package. Thixotropic polymers are combined with tobacco and other ingredients to prepare higher viscosity solutions suitable for use in other containers.
  • Tobacco particles can be of greater size, but must still be small enough to pass through the orifice of the container.
  • a stable tobacco slurry is contained in the bottle; tobacco particles are sized to be able to pass through a spray nozzle without blocking the orifice; and the tobacco slurry is sprayed directly in the oral cavity.
  • Liquid sprays are prepared by dissolving a thixotropic polymer such as xanthan, gellan or dextran in water and suspending tobacco particles in a low viscosity (e.g., ⁇ 50 centipoise) solution. Other compounds, such as flavor, sweetener and dispersant, can be added to the solution.
  • the tobacco particles are ground to a particle size (e.g., ⁇ 80 microns) to permit the homogeneous solution to pass through the orifice of a spray bottle.
  • Other packages may be otherwise squeezed or used to expel the tobacco into the oral cavity.
  • tobacco solutions may be included in any composition described herein.
  • a solution is prepared by mixing 0.2 grams of xanthan (Kelzan from C. P. Kelco) in 78.6 grams of cool water with vigorous mixing for 30 minutes. To this solution is added 20 grams of finely ground tobacco, 0.2 grams of sucralose, and 2 grams of cinnamon flavor while continuing to mix vigorously. The solution viscosity is adjusted with water to a viscosity of 50 centipoise.
  • xanthan Kelzan from C. P. Kelco
  • a solution is prepared by mixing 1 gram of xanthan (Kelzan from C. P. Kelco) with 76.8 grams of cool water while mixing vigorously for 30 minutes. To this is added 20 grams of fine tobacco, 0.2 grams of sucralose and 2 grams of cinnamon flavor while continuing to mix vigorously. Solution viscosity is 1,500 centipoise.
  • xanthan Kelzan from C. P. Kelco
  • a paste is prepared by adding 2 grams of a medium viscosity carboxymethyl cellulose (CMC 7MF from Hercules, Inc.) to a mixture of 35.8 grams of cool water and 40 grams of glycerine with vigorous mixing for 30 minutes. To this mixture is added 20 grams of fine tobacco powder, 0.2 grams of sucralose, and 2 grams of cinnamon flavor. A thick paste is prepared which is highly shear sensitive. This paste can be introduced to a tube or other squeezable package where the shear force from squeezing reduces the viscosity to permit flow of the paste.
  • CMC 7MF medium viscosity carboxymethyl cellulose

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Abstract

The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation of U.S. application Ser. No. 13/370,586, filed Feb. 10, 2012, which is a Divisional application of and claims benefit under 35 U.S.C. § 121 to U.S. application Ser. No. 12/345,063, filed Dec. 29, 2008, which is a divisional of U.S. application Ser. No. 10/982,248, filed Nov. 5, 2004, which claims benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 60/603,888, filed Aug. 23, 2004, and U.S. Provisional Application No. 60/518,352, filed Nov. 7, 2003, the entire contents of each of which are incorporated herein by reference.
    • FIELD OF THE INVENTION
  • The invention relates to the field of tobacco products.
    • SUMMARY OF THE INVENTION
  • The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.
  • For example, any composition described herein may include a flavor or flavor masking agent. Exemplary flavors include licorice, kudzu, hydrangea, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, menthol, Japanese mint, aniseed, cinnamon, herb, wintergreen, cherry, berry, apple, peach, Dramboui, bourbon, scotch, whiskey, spearmint, peppermint, lavender, cardamon, apium graveolens, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia, caraway, cognac, jasmin, ilangilang, sage, fennel, piment, ginger, anise, coriander, coffee, or a mint oil from any species of the genus Mentha.
  • Any composition of the invention may also include a sweetener (such as sucrose, sucralose, acesulfame potassium, aspartame, saccharine, cyclamates, lactose, sucrose, glucose, fructose, sorbitol, and mannitol); a surfactant; a plasticizer (such as glycerine, propylene glycol, polyethylene glycol, sorbitol/mannitol, acetylated monoglycerides, triacetin, and 1,3 butane diol); a filler (such as starch, microcrystalline cellulose, wood pulp, soluble fiber, calcium carbonate, dicalcium phosphate, calcium sulfate, and a clay); a lubricant (such as stearic acid and a stearate) or a wax (such as lecithin, glycerol monostearate, and propylene glycol monostearate); a preservative (such as methyl paraben and potassium sorbate); and/or a stabilizer (such as ascorbic acid, monosterol citrate, BHT, and BHA).
  • Any composition described herein may further include a coating, e.g., matte or glossy. The coating preferably includes a color, flavor, sweetener, or flavor masking agent. The coating may also include a different flavor, color, or rate of disintegration from the format in the composition. The coating may also include tobacco.
  • Any composition described herein may further include a printed pattern, e.g., in a logo. A printed pattern may include a color, tobacco, a flavor, sweetener, or flavor masking agent. The surface of any composition described herein may also include a pattern in relief.
  • Tobacco included in any composition may be a powder, granules, shreds, or perceived to be soluble in the mouth.
  • Any composition described herein may further include flakes, e.g., containing tobacco or a plurality of flavors or colors.
  • Any composition of the invention may be formed in a shape suitable for application in the mouth. A composition of the invention may further provide tobacco satisfaction, e.g., over a period of 10 s to 30 minutes.
  • The invention also features a method for obtaining tobacco satisfaction by placing at least a portion of any composition as described herein in the mouth.
  • The invention also features methods for making compositions as described herein. Any of these methods may further include adding a coating to the composition, e.g., by spraying, brushing, roll coating, doctor bar casting, slot coating, extrusion coating, or hot melt deposition. Any of the methods may also include printing a pattern on the composition, e.g., by offset, flexographic, gravure, ink jet, laser, or screen printing. In addition, the methods of making compositions may include adding a flavor, color, flavor masking agent, or any other ingredient described herein to the format or composition.
  • By “format” is meant an ingredient or compilation of ingredients, as provided herein, in a composition, for example, a carrier or agent.
  • By “tobacco” is meant any part, e.g., leaves, flowers, roots, and stems, of any member of the genus Nicotiana. Exemplary species of tobacco include N. rustica and N. tabacum (e.g., LA B21, LN KY171, TI 1406, Basma, Galpao, Perique, Beinhart 1000-1, and Petico). Other species include N. acaulis, N. acuminata, N. acuminata var. multiflora, N. africana, N. alata, N. amplexicaulis, N. arentsii, N. attenuata, N. benavidesii, N. benthamiana, N. bigelovii, N. bonariensis, N. cavicola, N. clevelandii, N. cordifolia, N. corymbosa, N. debneyi, N. excelsior, N. forgetiana, N. fragrans, N. glauca, N. glutinosa, N. goodspeedii, N. gossei, N. hybrid, N. ingulba, N. kawakamii, N. knightiana, N. langsdorffii, N. linearis, N. longiflora, N. maritima, N. megalosiphon, N. miersii, N. noctiflora, N. nudicaulis, N. obtusifolia, N. occidentalis, N. occidentalis subsp. hesperis, N. otophora, N. paniculata, N. pauciflora, N. petunioides, N. plumbaginifolia, N. quadrivalvis, N. raimondii, N. repanda, N. rosulata, N. rosulata subsp. ingulba, N. rotundifolia, N. setchellii, N. simulans, N. solanifolia, N. spegazzinii, N. stocktonii, N. suaveolens, N. sylvestris, N. thyrsiflora, N. tomentosa, N. tomentosiformis, N. trigonophylla, N. umbratica, N. undulata, N. velutina, N. wigandioides, and N. x sanderae. The tobacco may be whole, shredded, cut, cured, aged, fermented, or otherwise processed, e.g., granulated or encapsulated. Tobacco may also be in the form of finished products, including but not limited to any non-combustible tobacco that is orally consumed, e.g., smokeless tobacco. Such smokeless tobacco includes snuff (moist or dry), chewing tobacco, loose tobacco, pouched tobacco, and the like, or any form contained herein. The term also includes an extract of tobacco including two or more tobacco organoleptic components.
  • By “tobacco satisfaction,” in this case, is meant the experience associated with tobacco organoleptic components and added flavor components that are released in the mouth when using a smokeless tobacco. An adult consumer who chooses to use a smokeless tobacco product purchases a smokeless tobacco product typically according to their individual preference, such a preference includes, without limitation, flavor, cut of tobacco, form, ease of use, and packaging.
  • By “organoleptic” is meant relating or contributing to the integrated sensory perception by the consumer that includes, for example, any combination of aroma, fragrance, flavor, taste, odor, mouth feel, or the like.
  • By “non-combustible” is meant does not combust during ordinary usage.
  • Compositions described herein are advantageous from the perspective of size, ease of use, and controlled rate of disintegration.
  • All percentages are by weight unless otherwise noted.
  • Other features and advantages will be apparent from the following description and the claims.
    • DETAILED DESCRIPTION OF THE INVENTION
  • The invention features tobacco compositions that are typically for tobacco satisfaction.
    • A. Tobacco
  • Tobacco useful in compositions described herein includes any raw or processed form, e.g., a powder, granule, or shred. Preferably, the tobacco is sized or made to disintegrate in the mouth (e.g., dissolve), to give the perception of dissolvability (e.g., the tobacco does not produce a tactile experience in the mouth), or to be easily swallowed. Alternatively, the tobacco may be sized or made to provide a tactile experience in the mouth. Exemplary average sizes are in the range of 1 to 1000 μm, e.g., about 800, 500, 250, 100, 80, 75, 50, 25, 20, 15, 10, 8, 6, 5, 3, 2, or 1 μm or less, preferably 80 μm or less. The tobacco may also be in the form of a slurry or a flowable gel. A flowable gel is a mixture of a format dissolved in water and mixed with tobacco and then mixed with a miscible solvent that prevents the complete dissolution of the format. Such a mixture causes the format to swell forming a viscous paste that is pseudoplastic and is easily dispensed from a container (e.g., a tube) with slight pressure. An exemplary tobacco is smokeless tobacco. Additional tobaccos are described in U.S. Publication Nos. 2003/0094182, 2003/0070687, and 2006/0037623 and U.S. Ser. No. 60/603,887; the disclosures of which are hereby incorporated by reference. The tobacco employed in the composition may also be prepared according to the methods of U.S. Publication No. 2004/0112394; the disclosure of which is hereby incorporated by reference. Other suitable tobacco is known in the art.
  • Tobacco may be distributed randomly or evenly throughout a composition or concentrated in various regions thereof, e.g., in the center or on the surface.
  • Depending on the desired characteristics and the end use of the composition, the typical final tobacco concentration ranges from 1 percent to 99 percent by weight of the final composition, for example, at most 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, or 90%. In preferred embodiments, the composition includes around 25% tobacco.
    • B. Compositions
  • In general, compositions of the invention are intended for oral use or consumption. A composition containing tobacco may be manufactured using any suitable orally compatible format. The tobacco may be mixed directly with the format or otherwise supported by the format. For example, a composition may contain tobacco, e.g., as dried particles, shreds, granules, a powder, or a slurry, deposited on, mixed in, surrounded by, or otherwise combined with a format. Tobacco in compositions may or may not be, or be perceived to be, soluble. In one embodiment, the compositions are spitless tobacco compositions. Compositions may also include a mixture of forms or types of tobacco. Compositions may be foamed or dense. Foamed compositions may be rigid or flexible and may be based on water soluble, water insoluble, or thermoplastic formats. Exemplary compositions are described herein. In one embodiment, a composition of the invention is non-combustible.
  • Formats suitable for use in the compositions described herein include orally compatible polymers, such as cellulosics (e.g., carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), hydroxypropyl methyl cellulose (HPMC), and methyl cellulose (MC)), natural polymers (e.g., starches and modified starches, konjac, collagen, inulin, soy protein, whey protein, casein, and wheat gluten), seaweed-derived polymers (e.g., carrageenan (kappa, iota, and lambda), alginates, and propylene glycol alginate), microbial-derived polymers (e.g., xanthan, dextran, pullulan, curdlan, and gellan), extracts (e.g., locust bean gum, guar gum, tara gum, gum tragacanth, pectin (lo methoxy and amidated), agar, zein, karaya, gelatin, psyllium seed, chitin, and chitosan), exudates (e.g., gum acacia (arabic) and shellac), synthetic polymers (e.g., polyvinyl pyrrolidone, polyethylene oxide, and polyvinyl alcohol). Other useful formats are known in the art, for example, see Krochta et al. Food Technology, 1997, 51:61-74, Glicksman Food Hydrocolloids CRC 1982, Krochta Edible Coatings and Films to Improve Food Quality Technomic 1994, Industrial Gums Academic 1993, Nussinovitch Water-Soluble Polymer Applications in Foods Blackwell Science 2003. Depending on the desired characteristics, a composition may also include fillers (e.g., starch, microcrystalline cellulose, wood pulp (e.g., Solkafloc from International Fibers, Inc.), soluble fiber (e.g., Fibersol from Matsushita), calcium carbonate, dicalcium phosphate, calcium sulfate, and clays), lubricants (e.g., lecithin, stearic acid, stearates (e.g., Mg or K), and waxes (e.g., glycerol monostearate, propylene glycol monostearate, and acetylated monoglycerides)), plasticizers (e.g., glycerine, propylene glycol, polyethylene glycol, sorbitol, mannitol, triacetin, and 1,3 butane diol), stabilizers (e.g., ascorbic acid and monosterol citrate, BHT, or BHA), or other compounds (e.g., vegetable oils, surfactants, and preservatives). Some compounds function as both plasticizers and lubricants.
  • Compositions of the invention may include flavor extracts (e.g., licorice, kudzu, hydrangea, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, menthol, Japanese mint, aniseed, cinnamon, herb, wintergreen, cherry, berry, peach, apple, Dramboui, bourbon, scotch, whiskey, spearmint, peppermint, lavender, cardamon, apium graveolens, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia, caraway, cognac, jasmin, ilangilang, sage, fennel, piment, ginger, anise, coriander, coffee, or a mint oil from any species of the genus Mentha), flavor masking agents, bitterness receptor site blockers, receptor site enhancers, sweeteners (e.g., sucralose, acesulfame potassium (Ace-K), aspartame, saccharine, cyclamates, lactose, sucrose, glucose, fructose, sorbitol, and mannitol), and other desirable additives such as chlorophyll, minerals, botanicals, or breath freshening agents.
  • Flavors may also be provided by plant matter, e.g., mint leaves, which are typically 10% flavor oils and 90% insoluble fiber. Exemplary plants further include licorice, kudzu, hydrangea, Japanese white bark magnolia, chamomile, fenugreek, clove, Japanese mint, cinnamon, herb, cherry, berry, peach, apple, lavender, cardamon, apium graveolens, cascarilla, nutmeg, sandalwood, bergamot, geranium, rose, vanilla, lemon, orange, cassia, caraway, jasmin, ilangilang, sage, fennel, piment, ginger, anise, coriander, coffee, or any species of the genus Mentha.
  • Flavor may be provided to a composition as described herein by flavor extracts, plant matter, or a combination thereof. In addition to natural flavor extracts, flavor may also be provided by imitation, synthetic, or artificial flavor ingredients and blends containing such ingredients. Flavors may be added as a powder, an oil, or in encapsulated form.
  • In certain embodiments, the composition disintegrates in the mouth. Disintegration rates of compositions may vary from 60 minutes to less than 1 minute.
  • Fast release compositions typically disintegrate in under 2 minutes and most preferably, in 1 minute or less, e.g., less than 60 s, 50 s, 45 s, 40 s, 35 s, 30 s, 25 s, 20 s, 15 s, 10 s, 5 s, 4 s, 3 s, 2 s, or 1 s. The disintegration may occur by any mechanism, for example, dissolution, melting, mechanical disruption (e.g., from chewing), enzymatic or other chemical degradation, or disruption of the interaction between the format and tobacco. The format or tobacco itself may similarly disintegrate. The amount of time required for a composition to disintegrate may be controlled by varying the thickness of the composition and is dependent upon the type of format, other additives, and the pattern of usage. When placed in the mouth, the composition may temporarily adhere to a part of the oral mucosa. In addition, the length of time of the tobacco satisfaction may vary. This length of time may be affected by, e.g., by the rate of disintegration of a composition, the rate of extraction of organoleptic components from a composition, and the residence time of the composition in the mouth. The tobacco satisfaction may be provided over a period of at least 10 s, 30 s, 45 s, 1 min 2 min 3 min 5 min 10, min 15 min, 30 min, or 1 h, preferably from 10 s to 10 minutes and more preferably from 30 s to 5 minutes.
  • In other embodiments, the compositions do not disintegrate over the residence period in the mouth. In such compositions, introduction of tobacco organoleptic components into the mouth may occur by dissolution, leaching, extraction, or mechanical disruption caused by chewing.
  • Individual compositions may be sized to fit entirely in the mouth, or they may be sized to fit only partially in the mouth. Preferred cross sections of the compositions include, but are not limited to, square, circular, rectangular, elliptical, oval, and the like. Preferred dimensions may vary depending upon the serving size and ingredients. Typically, the largest dimension of a single serving is 5 cm or smaller. Alternatively, tobacco products may be made in a larger form, from which individual servings may be cut or otherwise separated, e.g., by chewing, biting, or oral disintegration. For example, a strip, or other long piece, may be placed in a container, and the consumer may remove a desired serving size. A larger composition (or orally sized piece attached to a handle) may also be partially inserted in the mouth, similar to a toothpick or cigarette, and the consumer may suck or chew on it. In one embodiment, the larger piece is orally disintegrable and may be completely consumed over a period of time.
    • C. Technologies
  • Films Compositions of the invention may be formed as films that may be orally disintegrable. Such films may contain a single layer or multiple layers. A single layer film will contain tobacco, a format, and other ingredients, e.g., in a homogeneous mixture. Multilayer films may include several tobacco containing layers, e.g., with the same or different kind or size of tobacco, e.g., tobacco perceived to be soluble. Multiple layers may be laminated together. In addition, multilayer films may contain tobacco in one or more layers and other layers that contain additional ingredients, as described herein. For example, individual layers may be added for flavor, sweetness, color, rate of disintegration, or stability (e.g., during handling or during consumption). Tobacco may also be placed between two or more layers in a sandwich arrangement. One or more of the layers in the sandwich may also include tobacco. In films having multiple layers, the layers may disintegrate at the same or different rates, or a layer may not disintegrate orally. When rates of disintegration differ, the composition may provide tobacco at differing times based on the layers disintegrating. Single layer films or individual layers in multilayer films may also be foamed or aerated to provide desirable physical properties or desirable dissolution or disintegration rates.
  • Films may be sized to fit in the mouth as individual servings. Alternatively, larger films may be fabricated from which individual servings may be separated. For example, a film may be wrapped, or otherwise shaped, to form a hollow tube or straw, which in turn may be filled with additional material. In addition, a film, e.g., containing a high percentage of tobacco in the range of 1% to 99% based on dry weight, may be fabricated and then used in preparation of flakes or a powder for addition to other compositions, as described herein. The preferred thickness of a film is typically less than 1 mm, e.g., less than 500, 200, 100, 50, 40, 30, 20, 10, 5, 4, 3, 2, or 1μm; preferably 5 to 125 μm.
  • Various methods known in the art can be used to manufacture films. The technique employed may depend on the format employed in the film. Exemplary methods include solution casting or extrusion, melt extrusion, drum drying, and calendaring. Once formed, a film may be modified, e.g., by printing or otherwise coating or decorating the surface of the film. Flavors, colors, or tobacco may be added to the surface of a film by a printing, coating, or decorative process. All printing processes known in the art, e.g., offset, flexographic, gravure, ink jet, laser, screen printing, and other typical methods, may be used. Coatings or decorative patterns may be applied to the surface of the film using processes known in the art, e.g., spraying, brushing, roll coating, doctor bar casting, slot coating, extrusion coating, hot melt deposition, depositing particles or flakes, and other typical methods. The film to be printed, coated, or decorated may or may not contain tobacco. One function of the printing, coating, or decorative pattern is to provide additional amounts of color, flavor, or tobacco to the film. Another function is to improve the dimensional stability and appearance of the film. Once the printed, coated, or decorated film has been prepared, an additional layer of film may be applied to cover, protect and seal the printed, coated, or decorated surface.
    • Film Examples
  • The following table shows exemplary ingredients for fabricating films of the invention.
  • TABLE A1
    Exemplary Preferred Example
    (%) (%) A (%)
    Water soluble polymer 10-70  20-45 30
    Tobacco 1-90 20-40 25
    Flavor 1-40  5-15 10
    Sweetener 0.2-6   2-5 3
    Fiber (Soluble or insoluble) 2-40  5-20 9
    Plasticizer 1-40  5-15 10
    Surfactants 0.05-5    0.1-1   0.5
    Starch/Maltodextrin 1-40 10-20 10.5
    Lubricant 0.5-10   1-3 2
    • EXAMPLE B Tobacco Film
  • A mixture of 50 grams of K-3 (60%), K-100 (35%) and K4M (5%) grades of hydroxypropylmethyl cellulose (HPMC) from Dow Chemical are added to a beaker containing 450 grams of well agitated, deionized water which has been heated to 180° F. While mixing, 40 grams of finely ground tobacco is added to the HPMC solution along with 15 grams of microcrystalline cellulose (FMC), 17 grams of starch (B-700 from Grain Processing Corp.), 16 grams of glycerine, 0.8 grams of polysorbate 80 (Unichema), and 4 grams of propylene glycol monostearate (PGMS from Danisco). Ten grams of cinnamon flavor and 2 grams of sucralose (artificial sweetener) are added to the solution when the temperature has dropped below 100° F. Two grams of sodium carbonate is added to adjust pH to approximately 7.5. Once all ingredients have been added and have been uniformly dispersed, the mixture is place in a water bath and, with continued mixing for 30 minutes, is reduced in temperature to 65° F. Additional water is added as required to obtain a Brookfield viscosity of 5,000 centipoise at a temperature of 65° F.
  • A portion of this tobacco containing solution described above is then spread on a glass plate using a draw down blade with a fixed gap of 15 mils (0.015 inches). The glass plate is placed in an air circulating laboratory oven preset at a temperature of 170° F. After 30 minutes, the glass plate is removed from the oven, cooled to room temperature, and the dry film with a thickness of 2.5 mils (0.0025 inches) is removed from the glass plate. The film may then be cut into smaller pieces suitable for placing in the mouth. A 1.0 inch by 1.25 inch section of the film will typically disintegrate in the mouth in less than one minute, thereby releasing the flavor, sweetener, and tobacco. The tobacco content of this film on a dry weight basis is 25%.
    • EXAMPLE C Opaque, Flavored Film
  • Using the same procedure as Example B, a solution is prepared without the addition of tobacco. While the solution is still hot, 32 grams of a titanium dioxide dispersion (50% titanium dioxide in water) supplied by Sensient Colors and 0.01 grams of FD&C Red No. 40 lake (Sensient Colors) are added with agitation. The solution is cooled to 65° F. and is spread on a glass plate, dried, and removed from the glass plate as described in Example B. An opaque, light red film of good strength and a dry film thickness of 1.5 mils (0.015 inches) is produced.
    • EXAMPLE D Two Layer Film
  • A portion of the solution from Example B is spread on a glass plate using a draw down blade with a fixed gap of 15 mils (0.015 inches). The glass plate is placed in a laboratory oven and the film is dried as in Example B. The glass plate is removed from the oven and cooled to room temperature, but the film is not removed from the glass plate.
  • A portion of the solution from Example C is spread over the dry film of Example B using a draw down blade with a fixed gap of 5 mils (0.005 inches). The glass plate is placed in the laboratory oven at 170° F. for 10 minutes. The dry film with a thickness of 3 mils (0.003 inches) is removed from the glass plate. The film is distinctly two sided with a layer of brown, tobacco containing film on one side and a red, flavored film on the opposite side. A 1.0 inch by 1.25 inch section of the film will typically disintegrate in the mouth in less than one minute.
    • EXAMPLE E Three Layer Film
  • A portion of the solution from Example C is spread on a glass plate using a draw down blade with a fixed gap of 5 mils and is dried in the laboratory oven as before. A portion of the solution from Example B is spread over the dried film of Example C using a draw down blade with a fixed gap of 15 mils and is dried in the laboratory oven as before. A portion of the solution from Example C is spread on a glass plate using a draw down blade with a fixed gap of 5 mils and is dried in the laboratory oven as before. The resulting film is 3 mils (0.003 inches) in thickness and is comprised of three layers with a layer of opaque, red, flavored film on either side and a center layer of tobacco containing film. A 1.0 inch by 1.25 inch section of the film will typically disintegrate in the mouth in less than one minute.
    • EXAMPLE F Foamed Film
  • To a 100 gram portion of tobacco containing solution from Example B is added with vigorous mixing, 0.5 grams of sodium lauryl sulfate (a surface active agent). This solution is then mixed on a high shear mixer such as a Silverson Laboratory Homogenizer, Model L4RT-W, to create a uniform bubble structure. This highly aerated solution is then spread on a glass plate using a draw down blade with a fixed gap of 4 mils (0.040 inches) and is dried in a laboratory oven. The dry, foamed film has a thickness of 4 mils (0.004 inches) when it is removed from the glass plate. The weight of a section of this foamed film of 1.0 inch by 1.25 inch by 4 mils (0.004 inches) in thickness is 35% lower than an identical section of unfoamed film as prepared in Example B. The dissolution rate of the foamed film in the mouth is typically faster when compared to the identical unfoamed film as prepared in Example B.
    • Example G Flakes
  • A solution is prepared in a beaker by adding 40 grams of spray dried Gum Arabic (TIC Gums, Inc.) and 0.4 grams of propylene glycol monostearate (PGMS) to 60 grams deionized water while mixing vigorously for 30 minutes. To 10 grams of this solution, 0.01 grams of FD&C Red No. 40 lake is added with high agitation to ensure uniform dispersion of the color. The solution is covered and set aside for 24 hours to permit all entrapped air to dissipate. A portion of this solution is then spread on a glass plate using a fig down blade with a fixed gap of 5 mils (0.005 inches). The glass plate is placed in a laboratory oven preset at 170° F. for 20 minutes until the film is thoroughly dried. When the film is removed from the glass plate, it breaks into many small pieces of high gloss, colorful, red flakes. This process is repeated with other FD&C lakes to produce flakes of many different colors. Flavors and artificial sweeteners can also be added to the flakes.
    • EXAMPLE H Tobacco Flakes
  • To 10 grams of the solution prepared in Example G is added 4 grams of finely ground tobacco powder. Films are prepared on glass plates and are dried, cooled, and removed in the same manner as in Example G. The resulting flakes are composed of 50% tobacco and 50% Gum Arabic and are a deep brown color. Flavors, if desired, can be added to the flakes. Materials such as sodium carbonate can also be added to the flakes to adjust pH.
    • EXAMPLE I Tobacco Film with Flakes
  • A film is prepared as in Example B. While the film is still wet on the glass plate, a measured quantity of flakes are prepared and are spread uniformly over the wet film. The glass plate is then dried in a laboratory oven; the film is cooled to room temperature and then removed from the glass plate. Typically, the dried film of Example B has a dry weight of 1 gram (containing 25% or 0.25 grams of tobacco). If this film is divided into 20 equal sections of film (1.0 inch by 1.25 inches by 2 mils), each section will weigh 50 milligrams (containing 25% or 12.5 milligrams of tobacco). If one gram of tobacco flakes (which are 50% by weight of tobacco) are spread uniformly over the film, the full piece of film will have a dry weight of 2 grams (containing a total of 0.75 grams of tobacco). When divided into 20 equal sections, each section will weigh 100 milligrams and will contain 37.5 milligrams of tobacco. The section of film cut into a 1.0 inch by 1.25 inch size will typically disintegrate in the mouth in less than one minute.
    • EXAMPLE J Tobacco Film with Decorative Flakes
  • The procedure outlined in Example I can be repeated using decorative flakes (e.g., colored flakes which do not contain any tobacco) or with blends of colored flakes and tobacco containing flakes. The resulting films have a colorful appearance.
    • EXAMPLE K Flavored Tobacco Film
  • TABLE K1
    HPMC 36.56%
    Starch 12.18%
    Tobacco 24.37%
    Na2CO3  1.46%
    Plasticizer 13.15%
    Flavors  6.82%
    Sweetener  0.49%
    Surfactant  0.97%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910(Wolff Cellulosics) 30.98 g
    HM100PA2208(Wolff Cellulosics) 15.51 g
    HM4000PA2910(Wolff Cellulosics)  2.60 g
    B700(Grain Processing Corporation) 16.36 g
    Tobacco Powder (average particle size < 80 μm) 32.72 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 1.96 g
    Propylene Glycol Monostearate 0.65 g
    Sodium Lauryl Sulfate 0.65 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin 5.89 g
    Propylene Glycol 5.22 g
    Polyethylene Glycol 400 6.54 g
    Cinnamon Flavor 6.54 g
    Tobacco Flavor Modifier (Hagelin) 2.62 g
    Sucralose Solution 25% (Tate & Lyle) 2.62 g
  • A total of 619.14 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point MIX1 was added. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 1 minute. The resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum. The vessel was attached to a Silverson L4RTU homogenizer motor unit. The solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10,000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • A portion of the resultant gel solution was poured onto a glass plate that had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 15 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 30 minutes, which had been set at 75° C. The resultant film, dried to approximately 4% moisture, was removed from the Mylar sheet and cut into appropriately sized units. A 1.0 inch by 1.25 inch unit of film disintegrated in the mouth in less than 30 seconds.
  • Relatively slower disintegrating films (e.g., films disintegrating in the mouth in greater than 30 seconds) were produced from the same solutions by casting the solution across the glass plate with a draw-down knife with a fixed gap of 30 mils. The films were dried in the same manner as above for 40 minutes. The films produced typically disintegrated in the mouth in less than 1 minute.
  • Super-fast disintegrating films (e.g., films disintegrating in the mouth in less than 15 seconds) were produced from the same solutions by foaming the solution prior to casting on the glass plate. Foaming was accomplished by subjecting 100 g of each solution to high shear mixing (with an Arrow Model 1750 high shear mixer) for approximately 3 minutes, after which the foamed solution was immediately cast on the glass plate with a draw-down knife with a fixed gap of 30 mils. The films produced typically disintegrated in the mouth in less than 15 seconds.
    • EXAMPLE L Flavored Tobacco Film
  • TABLE L1
    HPMC 36.56%
    Starch 12.18%
    Tobacco 24.37%
    Na2CO3  1.46%
    Plasticizer 10.71%
    Flavors  9.26%
    Sweetener  0.49%
    Surfactant  0.97%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910(Wolff Cellulosics) 30.98 g
    HM100PA2208(Wolff Cellulosics) 15.51 g
    HM4000PA2910(Wolff Cellulosics)  2.60 g
    B700(Grain Processing Corporation) 16.36 g
    Tobacco Powder (avg. particle size < 80 μm) 32.72 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 1.96 g
    Propylene Glycol Monostearate 0.65 g
    Sodium Lauryl Sulfate 0.65 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin 4.58 g
    Propylene Glycol 5.22 g
    Polyethylene Glycol 400 4.58 g
    Mint Flavor 9.81 g
    Tobacco Flavor Modifier (Hagelin) 2.62 g
    Sucralose Solution 25% (Tate & Lyle) 2.62 g
  • A total of 619.14 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point MIX1 was added. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 1 minute. The resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum. The vessel was attached to a Silverson L4RTU homogenizer motor unit. The solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • A portion of the resultant gel solution was poured onto a glass plate that had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 15 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 30 minutes, which had been set at 75° C. The resultant film, dried to approximately 4% moisture, was removed from the Mylar sheet and cut into appropriately sized units. A 1.0 inch by 1.25 inch unit of film typically disintegrated in the mouth in 15-30 seconds.
  • Alternatively, the film includes wintergreen, spearmint, or apple flavor.
  • Relatively slower disintegrating films (e.g., films disintegrating in the mouth in greater than 30 seconds) and super-fast disintegrating films (e.g., films disintegrating in the mouth in less than 15 seconds) were produced from the same solutions as described in Example K.
    • EXAMPLE M Peach Flavored Tobacco Film
  • TABLE M1
    HPMC 29.12%
    Starch  9.71%
    Tobacco 19.41%
    Na2CO3  1.16%
    Plasticizer  2.33%
    Peach Puree 29.66%
    Flavors  3.43%
    Sweetener  0.39%
    Surfactant  0.77%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910 (Wolff Cellulosics) 30.98 g
    HM100PA2208 (Wolff Cellulosics) 15.51 g
    HM4000PA2910 (Wolff Cellulosics)  2.60 g
    B700 (Grain Processing Corporation) 16.36 g
    Tobacco Powder (average particle size <80 μm) 32.72 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 1.96 g
    Propylene Glycol Monostearate 0.65 g
    Sodium Lauryl Sulfate 0.65 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin  1.31 g
    Propylene Glycol  1.31 g
    Polyethylene Glycol 400  1.31 g
    Peach Puree 100.0 g
    Peach Flavor  3.27 g
    Tobacco Flavor Modifier (Hagelin)  2.62 g
    Sucralose Solution 25% (Tate & Lyle)  2.62 g
  • A total of 619.14 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point MIX1 was added. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 1 minute. The resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum. The vessel was attached to a Silverson L4RTU homogenizer motor unit. The solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • A portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 15 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 30 minutes, which had been set at 75° C. The resultant film, dried to approximately 4% moisture, was removed from the Mylar sheet, and cut into appropriately sized units. A 1.0 inch by 1.25 inch unit of film typically disintegrated in the mouth in 15-30 seconds.
  • Relatively slower disintegrating films (e.g., films disintegrating in the mouth in greater than 30 seconds) and super-fast disintegrating films (e.g., films disintegrating in the mouth in less than 15 seconds) were produced from the same solutions as described in Example K.
    • EXAMPLE N Flavored Tobacco Film for Sticks/Wraps/Pouches/Vacuum Forming
  • TABLE N1
    HPMC 41.31%
    Starch 13.76%
    Tobacco  9.75%
    Na2CO3  1.46%
    Plasticizer 18.99%
    Flavors  9.27%
    Sweetener  0.49%
    Surfactant  0.98%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910 (Wolff Cellulosics) 38.48 g
    HM100PA2208 (Wolff Cellulosics) 19.27 g
    HM4000PA2910 (Wolff Cellulosics)  3.24 g
    B700 (Grain Processing Corporation) 20.32 g
    Tobacco Powder (avg. particle size <80 μm) 14.39 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 2.16 g
    Propylene Glycol Monostearate 0.72 g
    Sodium Lauryl Sulfate 0.72 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin  7.19 g
    Propylene Glycol  7.19 g
    Polyethylene Glycol 400  7.19 g
    Triacetin  6.47 g
    Cinnamon Flavor 10.80 g
    Tobacco Flavor Modifier (Hagelin)  2.88 g
    Sucralose Solution 25% (Tate & Lyle)  2.88 g
  • A total of 606.10 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point MIX1 was added. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 1 minute. The resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum. The vessel was attached to a Silverson L4RTU homogenizer motor unit. The solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • A portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C. The resultant film, dried to approximately 4% moisture, was removed from the Mylar sheet, and was stored in a plastic bag for future use.
  • Alternatively flavored tobacco films, e.g., apple flavored, were also produced following the preceding formulation and procedure.
    • EXAMPLE O Flavored/Colored Film for Sticks/Wraps/Pouches
  • TABLE O1
    HPMC 41.31%
    Starch 13.76%
    Fibersol-2  9.75%
    Na2CO3  1.46%
    Plasticizer 18.99%
    Flavors  9.26%
    Sweetener  0.49%
    Surfactant  0.79%
    Color  0.20%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910 (Wolff Cellulosics) 38.48 g
    HM100PA2208 (Wolff Cellulosics) 19.27 g
    HM4000PA2910 (Wolff Cellulosics)  3.24 g
    B700 (Grain Processing Corporation) 20.32 g
    Fibersol-2 (Matsutani) 14.39 g
    FD&C Red 40 Alum Lake 35-42% (Sensient Colors)  0.29 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 2.16 g
    Propylene Glycol Monostearate 0.58 g
    Sodium Lauryl Sulfate 0.58 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin  7.19 g
    Propylene Glycol  7.19 g
    Polyethylene Glycol 400  7.19 g
    Triacetin  6.47 g
    Cinnamon Flavor 10.79 g
    Tobacco Flavor Modifier (Hagelin)  2.88 g
    Sucralose Solution 25% (Tate & Lyle)  2.88 g
  • A total of 606.10 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point was added MIX1. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 1 minute. The resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum. The vessel was attached to a Silverson L4RTU homogenizer motor unit. The solution was homogenized under vacuum (20-25 inches) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • A portion of the resultant gel solution was poured onto a glass plate that had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C. Additional films were cast at 40 mils, and dried for 1 hour. The resultant films dried to approximately 4% moisture, were removed from the Mylar sheet, and were stored in a plastic bag for future use.
  • Alternatively flavors include mint flavor, wintergreen flavor, or spearmint flavor. Alternative colors include FD&C Blue Alum Lake 35-42%, FD&C Emerald Green Lake Blend, and FD&C Blue Alum Lake+FD&C Emerald Green Lake Blend.
    • EXAMPLE P Peach Flavored Film for Sticks/Wraps/Pouches
  • TABLE P1
    HPMC 31.73%
    Starch 10.57%
    Tobacco  7.49%
    Na2CO3  1.12%
    Plasticizer 14.59%
    Peach Puree 26.01%
    Flavors  3.37%
    Sweetener  0.37%
    Surfactant  0.75%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910 (Wolff Cellulosics) 38.48 g
    HM100PA2208 (Wolff Cellulosics) 19.27 g
    HM4000PA2910 (Wolff Cellulosics)  3.24 g
    B700 (Grain Processing Corporation) 20.32 g
    Tobacco Powder (average particle size <80 μm) 14.39 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 2.16 g
    Propylene Glycol Monostearate 0.72 g
    Sodium Lauryl Sulfate 0.72 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin  7.19 g
    Propylene Glycol  7.19 g
    Polyethylene Glycol 400  7.19 g
    Triacetin  6.47 g
    Peach Puree 100.0 g
    Peach Flavor  3.60 g
    Tobacco Flavor Modifier (Hagelin)  2.88 g
    Sucralose Solution 25% (Tate & Lyle)  2.88 g
  • A total of 606.10 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point was added MIX1. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 1 minute. The resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum. The vessel was attached to a Silverson L4RTU homogenizer motor unit. The solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • A portion of the resultant gel solution was poured onto a glass plate that had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C. The resultant film, dried to approximately 4% moisture, was removed from the Mylar sheet, and was stored in a plastic bag for future use.
    • EXAMPLE Q Flavored/White Opaque Film for Coating
  • TABLE Q1
    HPMC 45.46%
    Starch 15.15%
    Fibersol-2 10.73%
    Na2CO3  1.07%
    Plasticizer 10.73%
    TiO2 10.45%
    Flavors  1.07%
    Sweetener  0.27%
    Surfactant  1.07%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910 (Wolff Cellulosics) 38.48 g
    HM100PA2208 (Wolff Cellulosics) 19.27 g
    HM4000PA2910 (Wolff Cellulosics)  3.24 g
    B700 (Grain Processing Corporation) 20.32 g
    Fibersol-2 (Matsutani) 14.39 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 1.44 g
    Propylene Glycol Monostearate 0.72 g
    Sodium Lauryl Sulfate 0.72 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin  3.60 g
    Propylene Glycol  3.60 g
    Polyethylene Glycol 400  3.60 g
    Triacetin  3.60 g
    TiO2 suspension 50% (Sensient Colors) 28.04 g
    Tobacco Flavor Modifier (Hagelin)  1.44 g
    Sucralose Solution 25% (Tate & Lyle)  1.44 g
  • A total of 606.10 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point was added MIX1. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 1 minute. The resultant solution was transferred to a Silverson SS1 vessel, which had been adapted for mixing under vacuum. The vessel was attached to a Silverson L4RTU homogenizer motor unit. The solution was homogenized under vacuum (20-25 inches of Hg) for 2 minutes at 7500 RPM, after which an ice bath was placed around the homogenizer vessel. Homogenization continued under vacuum (20-25 inches of Hg) for 8 minutes at 10000 RPM. After homogenization was complete, a portion of the solution was transferred to a 500-mL Nalgene bottle for storage.
  • A portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C. The resultant film, dried to approximately 4% moisture, was removed from the Mylar sheet, and was stored in a plastic bag for future use.
    • EXAMPLE R Extruded Tobacco Films
  • TABLE R1
    Tobacco 25.63%
    Klucel LF 61.53%
    Na2CO3  3.32%
    Plasticizer  6.68%
    Sweetener  0.83%
    Water  2.00%
  • The following ingredients were granulated in a manner similar to granulations utilized for tab production, as described herein, yielding a tobacco granulation with an approximate moisture of 4.50%:
  •
    Klucel LF (Hercules/Aqualon) 3448.0 g
    Na2CO3  181.0 g
    Sucralose (Tate & Lyle)   45.0 g
    Propylene Glycol  363.0 g
    Tobacco Powder (average particle size <80 μm) 1451.0 g
    Water 2344.0 g
  • The tobacco granulation was introduced to the feed section of a Leistritz Micro-18 Twin Screw Extruder 40:1 L/D, which had been configured for co-rotating extrusion with a medium-shear screw design. Feed rates for the extrusion varied between 1-3 pounds per hour. Barrel zone temperatures varied between 75-240° F. Venting of volatiles from the extrusion melt was accomplished by incorporating a venting orifice prior to the discharge die of the extruder.
  • Tobacco film, with a width of approximately 3 inches and a thickness varying from 2-3 mils, was produced by incorporating a strip die at the discharge end of the extruder. Upon discharge, the tobacco film was calendared and cooled to room temperature by utilizing a 3-roll stacked chill roller. Downstream from the chill roller the film was taken up on a rewind reel, incorporating Mylar between the film layers to prevent adhesion. The tobacco film was placed in a container suitable for storage.
  • The tobacco film was subsequently used in the manufacture of dissolvable tobacco containing pouches, as described herein. The film disintegrated slowly in the mouth, over a period of 2-4 minutes.
    • EXAMPLE S Flavored Tobacco Film with Gelatin
  • TABLE S1
    HPMC 35.95%
    Gelatin  0.98%
    Starch 12.30%
    Tobacco 23.64%
    Na2CO3  1.47%
    Plasticizer 10.84%
    Flavors  9.35%
    Sweetener  0.50%
    Surfactant  0.97%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910 (Wolff Cellulosics) 13.84 g
    HM100PA2208 (Wolff Cellulosics)  7.24 g
    HM4000PA2910 (Wolff Cellulosics)  1.21 g
    B700 (Grain Processing Corporation)  7.63 g
    Gelatin  0.61 g
    Tobacco Powder (average particle size <80 μm) 15.27 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 0.91 g
    Propylene Glycol Monostearate 0.30 g
    Sodium Lauryl Sulfate 0.30 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin 2.14 g
    Propylene Glycol 2.44 g
    Polyethylene Glycol 400 2.14 g
    Mint Flavor 4.58 g
    Tobacco Flavor Modifier (Hagelin) 1.22 g
    Sucralose Solution 25% (Tate & Lyle) 1.22 g
  • A total of 288.93 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point was added MIX1. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 3 minutes. The resultant solution was transferred to a suitable container for storage.
  • A portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C. The resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and cut into appropriately sized units. A 1.0 inch by 1.25 inch unit of film dissolved in the mouth in less than 30 seconds, releasing flavor, sweetener, and tobacco.
    • EXAMPLE T Flavored Tobacco Film with Gelatin
  • TABLE T1
    HPMC 32.01%
    Gelatin  4.92%
    Starch 12.30%
    Tobacco 23.64%
    Na2CO3  1.47%
    Plasticizer 10.84%
    Flavors  9.35%
    Sweetener  0.50%
    Surfactant  0.97%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910 (Wolff Cellulosics) 11.40 g
    HM100PA2208 (Wolff Cellulosics)  7.24 g
    HM4000PA2910 (Wolff Cellulosics)  1.21 g
    B700 (Grain Processing Corporation)  7.63 g
    Gelatin  3.05 g
    Tobacco Powder (average particle size <80 μm) 15.27 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 0.91 g
    Propylene Glycol Monostearate 0.30 g
    Sodium Lauryl Sulfate 0.30 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin 2.14 g
    Propylene Glycol 2.44 g
    Polyethylene Glycol 400 2.14 g
    Mint Flavor 4.58 g
    Tobacco Flavor Modifier (Hagelin) 1.22 g
    Sucralose Solution 25% (Tate & Lyle) 1.22 g
  • A total of 288.93 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point was added MIX1. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 3 minutes. The resultant solution was transferred to a suitable container for storage.
  • A portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C. The resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and cut into appropriately sized units. A 1.0 inch by 1.25 inch unit of film disintegrated in the mouth in less than 30 seconds, releasing flavor, sweetener, and tobacco.
    • EXAMPLE U Flavored Tobacco Film with Gelatin
  • TABLE U1
    HPMC 27.09%
    Gelatin  9.85%
    Starch 12.30%
    Tobacco 23.64%
    Na2CO3  1.47%
    Plasticizer 10.84%
    Flavors  9.35%
    Sweetener  0.50%
    Surfactant  0.97%
    Water  4.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM3PA2910 (Wolff Cellulosics)  8.35 g
    HM100PA2208 (Wolff Cellulosics)  7.24 g
    HM4000PA2910 (Wolff Cellulosics)  1.21 g
    B700 (Grain Processing Corporation)  7.63 g
    Gelatin  6.11 g
    Tobacco Powder (average particle size <80 μm) 15.27 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Na2CO3 0.91 g
    Propylene Glycol Monostearate 0.30 g
    Sodium Lauryl Sulfate 0.30 g
  • In a third container were weighed the following ingredients:
  • MIX3
    Glycerin 2.14 g
    Propylene Glycol 2.44 g
    Polyethylene Glycol 400 2.14 g
    Mint Flavor 4.58 g
    Tobacco Flavor Modifier (Hagelin) 1.22 g
    Sucralose Solution 25% (Tate & Lyle) 1.22 g
  • A total of 288.93 g of boiling water was weighed into a stainless steel container. The water was stirred vigorously with an Arrow Model 1750 high shear mixer. To the water was added MIX2. Stirring was continued for 30 seconds, at which point was added MIX1. Vigorous stirring was continued for 4 minutes. To the resultant solution was added MIX3. Vigorous stirring was continued for 3 minutes. The resultant solution was transferred to a suitable container for storage.
  • A portion of the resultant gel solution was poured onto a glass plate which had previously been covered with an appropriately sized sheet of Mylar. The gel solution was drawn across the glass plate with a draw-down knife with a fixed gap of 20 mils. The glass plate was placed in a side-swept forced air oven (VWR model 1330FM), for 35 minutes, which had been set at 75° C. The resultant film dried to approximately 4% moisture, was removed from the Mylar sheet, and cut into appropriately sized units. A 1.0 inch by 1.25 inch unit of film disintegrated in the mouth in less than 30 seconds, releasing flavor, sweetener, and tobacco.
  • Tabs. Compositions of the invention may also be produced as tabs, such as super fast disintegrate (about 15 seconds), fast disintegrate (less than 2 minutes), slow disintegrate (2-10 minutes), and chewable tabs.
  • Tabs may be sized as individual servings or smaller, a plurality of which constitute an individual serving. Tabs sized as individual servings typically have dimensions of 5 mm to 15 mm. Smaller tabs typically range from 2 to 4 mm in diameter. Such smaller tabs may be fabricated in a variety of colors or flavors, e.g., for simultaneous consumption. Tabs may be shaped as a wafer, a convex or concave pellet, ovals, or any other shape known to the trade. Tabs may also be foamed to provide faster dissolution or disintegration in the mouth. Tabs may also be layered to provide a variety of tastes or mouth feels as the tab dissolves or disintegrates. Tabs may also be coated to modify color or taste or to provide mechanical strength for improved handling. In one embodiment, a tab designed to disintegrate rapidly in water may be coated with a very thin water insoluble coating to provide protection to the tab while a second, water soluble coating is applied.
  • Tabs may be fabricated from a dry mix, known as direct compression or from pregranulated materials by any forming method known in the art, e.g., via a press, injection molding, compression molding, injection foam molding, or compression foam molding.
  • Tab Examples
  • The following table shows exemplary ingredients for fabricating tabs of the invention.
  • TABLE V1
    Exemplary Ex. V Ex. W Ex. X Ex. Y
    Range (%) Fast (%) Fast (%) Slow (%) Slow (%)
    Water soluble  0-70 0 3 23 0
    polymer
    Tobacco  1-70 27 20 27 30
    Flavor Oil 0.5-4.0 2 1.8 2 2
    Artificial 0.05-0.4  0.15 0.15 0.15 0.1
    Sweetener
    Sugar  1-80 64 35 45.85 33.3
    Maltodextrin  0-50 0 19 0 0
    Disintegrant 0.1-15  6.35 3.0 — —
    Starch  5-80 0 17.35 — 50
    Release Agent 0.1-2.0 0.5 0.5 0.5 0.5
    Emulsifier 0.1-5.0 0 0.2 0.5 0.1
    • EXAMPLE Z Exemplary Chewable Tab
  • A chewable tab can be formed using the following ingredients: compressible sugar (40%); tobacco (20%); dextrose (25%); maltodextrin (13%); coloring agents (0.05%); flavor (1.35%); and magnesium stearate (0.60%).
    • EXAMPLE AA Thermoplastic Tab
  • A thermoplastic tab can be formed using the following ingredients (in parts): hydroxypropyl cellulose (HPC) 54; tobacco 27; microcrystalline cellulose 10; propylene glycol 4; artificial sweetener 2; flavor 2; and stabilizer 0.2. The ingredients are dry mixed and fed to an extruder using barrel temperatures necessary to melt the HPC (typically 340-370° F.). A rod of about ½ inch diameter is extruded and cut to size sufficient to form a tab.
    • EXAMPLE AB Tobacco Tab
  • TABLE AB1
    Formulation of Tobacco Tab
    Ingredients % Dry Weight Basis
    Tobacco Powder 25.00
    Sweetener 32.11
    Maltodextrin 40.22
    Flavors 0.75
    Emulsifier 1.36
    Na2CO3 0.56
    Total 100.00
  • TABLE AB2
    Formulation of Binding Solution for Production of Tobacco Tab
    Ingredients Percent
    Water 45.00
    Maltodextrin 53.05
    Emulsifier 1.80
    Sweetener 0.15
    Total 100.00
    • Preparation of Binding Solution
  • Ingredient amounts, as noted in Table AB2, were weighed out into separate containers. Gum Arabic Pre-hydrated (emulsifier) was slowly added to the water and mixed under high shear agitation in a stainless steel vessel. After complete dissolution, M 585 maltodextrin (Grain Processing Corporation) was added slowly to the water. Once M 585 was completely dissolved, the Sucralose sweetener (Tate & Lyle) was added slowly and mixed thoroughly to ensure complete dissolution.
  • Formulary amounts of peppermint and spearmint flavors and Na2CO3 as noted in Table AB1 were added to the binding solution. The entire mixture was homogenized for approximately 20 minutes at 9000-10000 RPMs with the aid of a homogenizer. The proper amount of binding solution to use was determined by the batch size and the ingredient percentages shown in Table AB 1. The homogenized solution was transferred into the flavor holding/pumping tank.
    • Preparation of Dry Ingredients
  • The formulary amounts of mannitol (sweetener) and tobacco powder (bone dry basis), as noted in Table AB1, were blended together and placed in the product bowl.
    • Preparation of Vector Multiflo-15 Fluid Bed Chamber
  • A Vector Multiflo-15 fluid bed coater was used to apply the binding solution to the dry ingredient blend to form the final granulation. The manual process was selected on the control panel computer. The machine operating parameters, located in Table AB3, were loaded into the program:
  • TABLE AB3
    Vector Multiflo-15 Fluid Bed
    Parameter Settings
    Inlet Temperature (Celsius) 60
    Airflow (CFM) 150
    Flowrate (G/Min) 125
    Filter Pulse Interval (Sec) 30
    Post-Pulse Time (Sec) 60
  • The appropriate amount of binding solution to be sprayed on was also loaded into the program. The binding solution amount was determined by the desired batch size to achieve the ingredient percentages shown in Table AB 1.
    • Granulation Process
  • Once the dry ingredients were fluidized in the fluid bed chamber and achieved a temperature of 40-45° C., the binding solution was slowly sprayed onto the dry ingredients to form the granulation. The nozzle pressure was set at 22 psi and airflow at 200 CFM. The airflow was increased to ensure good product movement or fluidization in the fluid bed chamber. Once all the binding solution had been applied, the airflow was reduced to 200 CFM. The process was stopped once the product temperature reached approximately 43° C.
    • Preparation of Granulation for Forming Tabs
  • The granulated material was then sized through a 12-mesh screen. The magnesium stearate (lubricant) was sized through a 40-mesh screen. The formulary amount of magnesium stearate as noted in Table AB4 was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
  • TABLE AB4
    Formulation of Ingredients for Forming Tabs
    Ingredients % Dry Weight Basis
    Granulated Material 99.50
    Lubricant 0.50
    Total 100.00
    • Tab Forming Process
  • The granulated material plus lubricant was loaded into the hopper of the press. The following parameters noted in Table AB5 were set on the Vanguard VSP 8 Mini Rotary Press:
  • TABLE AB5
    Parameters for Tobacco Tab
    Fast Disintegrate Slow Disintegrate
    Parameters Settings Ranges Settings Ranges
    Fill Depth (MM) 8.0 11.3 11.3-11.4
    Thickness (MM) 1.3 1.8
    Principal Pressure (KN) 5.0 10.8-12.0
    Ejection Pressure (MM) 0.03-0.12
  • Fast disintegrate disintegrated in the mouth within 1 to 3 minutes. Slow disintegrate disintegrated in the mouth between 5-8 minutes.
    • EXAMPLE AC Tobacco Tab
  • TABLE AC1
    Formulation of Tobacco Tab
    Ingredients % Dry Weight Basis
    Tobacco Powder 25.00
    Sweetener 34.11
    Maltodextrin 38.58
    Flavors 1.00
    Emulsifier 1.31
    Total 100.00
  • TABLE AC2
    Formulation of Binding Solution for Production of Tobacco Tab
    Ingredients Percent
    Water 45.00
    Maltodextrin 53.04
    Emulsifier 1.80
    Sweetener 0.16
    Total 100.00
  • The procedures previously stated in Example AB1 for binding solution preparation were followed. Formulary amounts of peppermint and spearmint flavors as noted in Table AC1 and 45.00 grams of Na2CO3 were added to binding solution. The remaining procedures for the make-up for the binding solution, preparation of dry ingredients, preparation of Vector Multiflo-15 Fluid Bed Chamber, and granulation process were followed.
    • Preparation of Granulation for Forming Tabs
  • The granulated material and magnesium stearate were sized through the appropriate screens as previously stated. The formulary amount of magnesium stearate (0.75% for a fast disintegrate or 1.00% for a slow disintegrate) was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
    • Tab Forming Process
  • The machine operating parameters noted in Table AC3 were set on the Vanguard
  • TABLE AC3
    Tab Forming Parameters for Tobacco Tab
    Fast Disintegrate Slow Disintegrate
    Parameters Settings Ranges Settings Ranges
    Fill Depth (MM) 6.8 9.9
    Thickness (MM) 1.1 2.0-2.1
    Principal Pressure (KN) 6.9-7.2 3.8-4.0
    Ejection Pressure (MM) 0.03-0.15
    • EXAMPLE AD Tobacco Tab
  • TABLE AD1
    Formulation of Tobacco Tab
    Ingredients % Dry Weight Basis
    Tobacco Powder 25.00
    Filler 30.00
    Maltodextrin 42.15
    Flavor 0.75
    Emulsifier 1.43
    Sweetener 0.12
    Na2CO3 0.56
    Total 100
  • TABLE AD2
    Formulation of Binding Solution for Production of Tobacco Tab
    Ingredients Percent
    Water 45.00
    Maltodextrin 53.06
    Emulsifier 1.80
    Sweetener 0.14
    Total 100.00
  • The procedures previously stated for binding solution preparation were followed. Formulary amounts of Cinnamon Flavor and Na2CO3 as noted in Table AD1, were added to the binding solution. The remaining procedures for the make-up of the binding solution, preparation of dry ingredients (lactose filler combined with tobacco powder), preparation of the Vector Multiflo-15 Fluid Bed Chamber, and the granulation process were followed.
    • Preparation of Granulation for Forming Tabs
  • The granulated material and magnesium stearate were sized through 12- and 40-mesh screens, respectively. The formulary amount of magnesium stearate (0.50% for a fast disintegrate or 1.00% for a slow disintegrate) was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
    • Tab Forming Process
  • The parameters noted in Table AD3 were set on the Vanguard VSP 8 Mini Rotary Press:
  • TABLE AD3
    Tab Forming Parameters for Tobacco Tab
    Fast Disintegrate Slow Disintegrate
    Parameters Settings Ranges Settings Ranges
    Fill Depth (MM) 7.7 11.2 11.2-11.3
    Thickness (MM) 1.1 1.7 1.7-1.8
    Principal Pressure (KN) 5.7-6.0 3.8-4.0
    Ejection Pressure (MM) 0.03-0.08 0.03-0.17
    • EXAMPLE AE Tobacco Tab
  • The same procedures were followed for making a Tobacco Tab in Example AD except wintergreen flavor was used in place of cinnamon flavor.
    • Preparation of Granulation for Forming Tabs
  • The finished material was then sized through a 12-mesh screen. The magnesium stearate was sized through a 40-mesh screen. The formulary amount of magnesium stearate (0.50% for a fast disintegrate or 0.75% for a slow disintegrate) was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
    • Tab Forming Process for Tobacco Tab
  • The parameters noted in Table AE1 were set on the Vanguard VSP 8 Mini Rotary Press:
  • TABLE AE1
    Tab Forming Parameters for Tobacco Tab
    Fast Disintegrate Slow Disintegrate
    Parameters Settings Ranges Settings Ranges
    Fill Depth (MM) 8.1 12.0 12.0-12.1
    Thickness (MM) 1.1 1.1-1.2 1.8
    Principal Pressure (KN) 5.7 5.7-6.0 4.5 4.5-5.2
    Ejection Pressure (MM) 0.03-0.09 0.04-0.19
    • Example AF Tobacco Tab with an Opaque, White Coating
  • TABLE AF1
    Formulation of Tobacco Tab
    Ingredients % Dry Weight Basis
    Tobacco 25.00
    Filler 30.00
    Maltodextrin 39.74
    Flavor 0.75
    Emulsifier 1.35
    Sweetener 0.10
    Na2CO3 0.56
    Tobacco Flavor Modifier 2.50
    Total 100
  • TABLE AF2
    Formulation of Binding Solution for Production of Tobacco Tab
    Ingredients Percent
    Water 45.00
    Maltodextrin 53.07
    Emulsifier 1.80
    Sweetener 0.13
    Total 100
    • Preparation of Binding Solution
  • The procedures previously stated for binding solution preparation were followed. Formulary amounts of apple flavor, natural bitter blocker (Comax), and Na2CO3 as noted in Table AF1 were added to binding solution. The remaining procedures for the make-up of the binding solution, preparation of dry ingredients (lactose filler plus tobacco powder), preparation of the Vector Multiflo-15 Fluid Bed Chamber, and the granulation process were followed.
    • Preparation of Granulation for Tab Forming
  • The finished material was then sized through a 12-mesh screen. The magnesium stearate was sized through a 40-mesh screen. The formulary amount of magnesium stearate (0.75% for a slow disintegrate) was combined with the granulated material in a plastic bag and manually shaken for 2 minutes.
  • Tab Forming Process The parameters noted in Table AF3 were set on the Vanguard VSP 8 Mini Rotary Press:
  • TABLE AF3
    Tab Forming Parameters for a Slow Disintegrate Tobacco Tab
    Parameters Settings Ranges
    Fill Depth (MM) 13.6 13.5-13.7
    Thickness (MM) 2.4 2.4-2.5
    Principal Pressure (KN) 4.5-5.2
    Ejection Pressure (MM) 0.04-0.24
    • Tobacco Tab Coating-Suspension Makeup
  • A 20% Opadry II aqueous solution was prepared as directed by the manufacturer and allowed to mix 45 minutes prior to coating.
    • Coating Process
  • Tabs (5.5-6.5 KG) were placed in the coating pan of a Vector/Freund Hi-Coater pan coating machine and warmed until the exhaust temperature reached 45° C. This was done with the pan running at less than 5 RPMs to minimize Tab attrition. Air at 75° C. and 100 CFM ran across the pan at a pan pressure of -0.5″ water.
  • Once the tabs reached temperature, the pan speed was increased to approximately 15 RPMs and the Opadry coating suspension was applied at a rate of 15-20 grams/minute. The suspension was continually mixed during application to prevent the solids from settling. The spray was atomized with approximately 100 liters of air per minute at approximately 70 psi. The atomized spray was formed into a pattern using directional air ports on the nozzle set at approximately 50 liters of air per minute at approximately 70 psi.
  • Inlet air temperature was periodically increased or decreased to maintain an exhaust temperature between 43 and 46° C.
  • Spraying was continued until desired amount of solids was applied to satisfy formulary requirements which was typically around 3%, or until tabs were visually satisfactory.
    • Example AG Tobacco Solid Disintegratable
  • The following ingredients were weighed out into individual containers:
  •
    Klucel EF (Hercules)   60 g
    Tobacco Powder   75 g
    Tobacco Flavor Modifier   6 g
    Corn Syrup (65%)   45 g
    Sucrose   45 g
    B700 (Grain Processing Corp.)   51 g
    Sucralose Solution 25% (Tate & Lyle)   3 g
    Propylene Glycol   3 g
    Sodium Carbonate  1.5 g
    Water   6 g
    Oil of Peppermint  4.5 g
    Water portion 1 (hot)  120 g
    Water portion 2 (cold)  120 g
  • The 6 g of water was added to the sodium carbonate, and the mixture was stirred. This mixture was allowed to stir until it was added to the other ingredients later in the process.
  • Water portion 2 (cold) was placed in an ice bath to chill while water portion 1 (hot) was heated to 60° C. and transferred to a stainless steel container. The 60° C. water was stirred with an Arrow Model 1750 high shear mixer and the Klucel EF gradually added to the water. This solution was stirred for several minutes. Water portion 2 (cold) was then added to the mixture. An ice bath was placed under the stainless steel container, and the mixture was stirred for 15 minutes.
  • After 15 minutes of stirring, the remaining ingredients were added to the mixture one at a time. The mixture was thoroughly blended prior to the addition of the next ingredient. The ingredients were added in the following order: tobacco flavor modifier, propylene glycol, sucralose solution, corn syrup, sodium carbonate solution, sucrose, tobacco powder, B700, and oil of peppermint. Ice was added to the ice bath throughout the mixing process to keep the mixture cold. After all ingredients were added, the mixture was stirred for an additional 10 minutes.
  • The container was removed from the ice bath and the mixture was dispensed in solid disintegratable portions onto wax paper and allowed to dry at room temperature for 24 hours. The solid disintegratables were removed from the wax paper and transferred to another sheet of wax paper to continue drying at room temperature. The desired hardness for the solid disintegratables was achieved after 12 to 24 hours of continued drying.
    • EXAMPLE AH Tobacco Solid Disintegratable
  • The following ingredients were weighed out into individual containers:
  •
    HPMC 2910 HM E5/6 Bv (Celanese)   60 g
    Tobacco Powder   75 g
    Tobacco Flavor Modifier   6 g
    Corn Syrup (65%)   45 g
    Sucrose   45 g
    B700 (Grain Processing Corp.)   39 g
    Sucralose Solution 25% (Tate & Lyle)   3 g
    Propylene Glycol   15 g
    Sodium Carbonate  1.5 g
    Water   6 g
    Oil of Peppermint   4.5 g
    Water portion 1 (hot)  120 g
    Water portion 2 (room temp.)  120 g
  • The 6 g of water was added to the sodium carbonate, and the mixture was stirred. This mixture was allowed to stir until it was added to the other ingredients later in the process.
  • Water portion 1 (hot) was heated to 80° C. and transferred to a stainless steel container. The 80° C. water was stirred with an Arrow Model 1750 high shear mixer, and the HPMC gradually added to the water. This solution was stirred for several minutes. Water portion 2 (room temp.) was then added to the mixture, and the mixture was stirred for 15 minutes.
  • After 15 minutes of stirring, the remaining ingredients were added to the mixture one at a time. The mixture was thoroughly blended prior to the addition of the next ingredient. The ingredients were added in the following order: tobacco flavor modifier, propylene glycol, sucralose solution, corn syrup, sodium carbonate solution, sucrose, tobacco powder, B700, and oil of peppermint. After all ingredients were added, the mixture was stirred for an additional 10 minutes.
  • The mixture was dispensed in portions onto wax paper and allowed to dry at room temperature for 24 hours. The solid disintegratables were removed from the wax paper and transferred to another sheet of wax paper to continue drying at room temperature. The desired hardness for the solid disintegratables was achieved after 12 to 24 hours of continued drying.
  • A similar product was made using the same formulation, mixing process, and dispensing process, but the solid disintegratables were dried in a forced air oven (VWR Model 1330FM) set at 32° C. for one hour. The solid disintegratables were then removed from the oven and dried at room temperature for 24 hours. Additionally, solid disintegratables were dried in the forced air oven at 32° C. for 18 hours. A slightly harder solid disintegratable with a dull finish was achieved with this drying technique.
    • EXAMPLE AI Multilayer Tab
  • Commercially available press equipment can be used to prepare tabs with two or more distinct layers. The composition of these layers can be the same or different in composition. Individual layers can be differentiated by color, flavor, tobacco type, tobacco content, dissolution rate, and other similar characteristics. For example, one layer could disintegrate very rapidly to release flavor or flavor masking ingredients. A second layer containing tobacco powder could disintegrate more slowly thereby gradually exposing the tobacco.
  • Shaped Parts. Tobacco compositions may also be formed into products that are sufficiently rigid to be easily handled. These shaped products may vary in physical properties and range from highly flexible to highly stiff parts. Such products may be formed into any shape and be dense or foamed. These compositions typically have a moisture content of 2-50%, preferably 5-10%, of the finished part weight. Exemplary shapes include a tube, a toothpick, a stick, a twist, or a solid rod. Typically, a shaped part will be sucked or chewed on for an extended period of time to release tobacco organoleptic components into the mouth. A shaped part may or may not disintegrate orally. Parts that disintegrate may do so over a period of 1-60 minutes, preferably from 1-10 minutes.
  • Shaped parts may or may not be sized to fit entirely in the mouth. Compositions larger than the mouth may be partially inserted. Typically the largest dimension of a shaped part is 6 inches, more preferably 2.5 inches.
  • Shaped parts may contain discrete regions, e.g., with each region having the same or different flavor or color or size or form of tobacco, e.g., tobacco perceived as soluble. For example, a twist may contain individual strands, each having a different flavor or color or size or form of tobacco. As further examples, shaped parts may be prepared in multistep processes in which molded or extruded parts are composed of layers, two or more of which contain different flavors, colors, or sizes or forms of tobacco.
  • Shaped part compositions may be fabricated by any method known in the art, e.g., extrusion, compression molding, injection molding, impact forming, foam molding, blow molding, and overmolding. In addition, shaped parts may be based on water soluble or thermoplastic formats. In one embodiment, an aqueous-based shaped part is fabricated by forming a viscous paste (e.g., via Hobart process) of the format, water, tobacco, and other ingredients and pressing the paste into a form, extruding through a die, or forming a sheet from which shapes are cut. The cut or formed part may then be dried to the desired moisture level of from 2-50%, preferably from 5-10% of the finished part weight for very rigid parts and from 10-50% for highly flexible parts. In another embodiment, the aqueous paste can be formed in a two stage extrusion process (e.g., via a Wenger twin screw extruder) in which the format, water, tobacco, and other ingredients are blended in a mixing or pre-extrusion stage of the machine, and the resulting paste is fed directly to the twin screw extrusion element of the machine and is extruded through a die to form a shape, which is then dried to the desired moisture level. A thermoplastic-based shaped part is fabricated, for example, by mixing components via a PK blender, high intensity mixer, pre-pelletizer, or granulation (fluid bed or Hobart) process. The mixed components may then be extruded through conventional single or twin screw extruders to form shaped parts or the mixture can be fed into injection molding machines or other thermoplastic processing machinery to form shaped parts.
    • Shaped Part Examples EXAMPLE AJ Injection Molded Shaped Parts
  • The following table provides exemplary shaped parts to be formed by injection molding.
  • TABLE AJ1
    1 2 3 4 5 6 7 8
    Ingredient % % % % % % % %
    Tobacco 47.98 45.59 67.18 63.83 78.22 74.32 29.33 27.87
    Low viscosity 48.02 45.62 28.84 27.40 19.59 18.61 68.48 65.06
    HPC
    Water 4 3.80 3.98 3.78 2.19 2.08 2.19 2.08
    Propylene 4.99 4.99 4.99 4.99
    glycol
  • Heating zones were Zone 1—300-340° F.; Zone 2—350-370° F.; Zone 3—300-340° F.; mold temperature was ambient. Sufficient composition was fed to the screw to equal one injection cycle; the material was immediately injected into the mold; the mold was opened after 10 seconds; and the part was removed. The shaped part was a stepped color chip, 2 inches by 3 inches by steps at ⅛th, ¼th, and ⅜th inch thickness.
    • EXAMPLE AK Compression Molded Shaped Parts
  • The following table provides exemplary shaped parts formed by compression molding.
  • TABLE AK1
    A B C D E F G
    Ingredient % % % % % % %
    Tobacco 26.47 25.00 25.00 30.00 25.00 25.00 25.00
    Corn starch 49.41 30.30 9.50 60.60 30.30 56.60
    Starch B-820 30.30
    Maltodextrin 30.30
    Low viscosity HPC 45.00
    Soluble fiber 30.30 30.30
    Cinnamon 4.41 5.00 5.00 5.00 5.00 5.00 5.00
    Flavor oil 4.41 5.00 5.00 5.00 5.00 5.00 5.00
    Sucralose 0.88 0.90 0.90 0.90 0.90 0.90 0.90
    Sodium carbonate 2.65 2.50 2.50 2.50 2.50 2.50 2.50
    Glycerin 1.00 1.00 2.00 1.00 1.00 5.00
    Propylene glycol 11.77
  • 10-50 grams of water is added per 100 grams of dry compound—sufficient to soften the mix and enable it to pass through a pasta die mounted on a mixer. The mold parameters are as follows:
  • TABLE AK2
    Mold Temperature 220-280° F.
    Residence Time 5 seconds to 60 seconds
    Toothpick mold cavity 5/32nds inch diameter by 2⅜th length
    Stick mold cavity ⅜th inch diameter by 2⅜th length
    Disc mold cavity ¾ inch diameter by ¼ inch depth
  • Longer residence times produced more rigid parts, as long as the steam was allowed to freely vent during the expansion of the part. Additives may also be employed so that the shaped part remains flexible after removal from the tool. The parts containing a majority of low viscosity HPC formed excellent pieces if left in the tool for an extended time (40 to 60 seconds). The inclusion of plasticizer increased the rate of moisture absorption from the atmosphere, which caused some parts to soften over time.
  • When the mold cavities were completely filled with molding compound, dense and rigid parts were prepared. When the mold cavities were filled to about 75% of the mold capacity, the compound expanded under the pressure of expanding steam to form foamed parts which had good rigidity, good flavor, and which disintegrated readily in the mouth.
  • Foaming can be accomplished in aqueous systems by incorporating a surface active agent (e.g., sodium lauryl sulfate) into the mix and beating to incorporate air; foaming or aeration can also be achieved by introducing a gas (e.g. nitrogen) to the aqueous system while the composition is under high shear. The aqueous system is then dried to the desired moisture level to create a stable foamed composition. In one embodiment, an aqueous composition is introduced to partially fill a compression mold; the mold is closed; the mold temperature is raised above the boiling point of water to form steam, which expands the aqueous composition to fill the void area and to create a foamed, shaped part. For thermoplastic systems, foaming can be accomplished by incorporating water into the tobacco/format composition; the temperature is raised to above the boiling point of water to form steam; and, as the tobacco composition exits a die, the steam expands to create a foamed structure. In another embodiment, gas (e.g., nitrogen or carbon dioxide) is introduced into the molten, thermoplastic, tobacco composition prior to its discharge from an extruder resulting in a highly uniform foam structure in the shaped tobacco composition. Other thermoplastic foaming processes well known in the art (e.g., injection foam molding) can be used to create foamed, tobacco compositions and shaped parts.
    • EXAMPLE AL Exemplary Aqueous Shaped Parts
  • Tables AL1 and AL2 show exemplary ingredients for fabricating aqueous shaped parts of the invention. Sufficient water is added to form a viscous paste.
  • TABLE AL1
    Exemplary
    (parts) Preferred Example
    Tobacco  1-80 30-50 54
    Flavor 0.5-4   2.5-3    3
    Insoluble Fiber 4.5-36  22.5-27   27
    Water Soluble  1-50  5-20 10 CMC 7MF
    Polymer (medium viscosity)
    Filler/Disintegrant  1-50 10-30 30 microcrystalline
    cellulose
    Artificial Sweetener 0.05-5   0.1-2   0.2 Sucralose
    Dispersant 0.1-20  0.1-2   0.2 Sodium Lauryl
    Sulfate
  • TABLE AL2
    Exemplary
    (parts) Preferred Example
    Tobacco  1-80 20-50 27
    Flavor 0.5-4   1-3  1
    Insoluble Fiber 4.5-36   9-27  9
    Water Soluble Polymer  1-50  5-25 18 low viscosity
    HPC
    Filler/Disintegrant  1-50 10-30 10 microcrystalline
    cellulose
    Artificial Sweetener 0.05-3   0.1-1   0.5 Sucralose
    Dispersant 0.1-20  0.1-2   0.2 sodium lauryl
    sulfate
    • EXAMPLE AM Exemplary Thermoplastic Shaped Parts
  • Table AM1 shows exemplary ingredients for fabricating thermoplastic shaped parts of the invention.
  • TABLE AM1
    Exemplary
    (parts) Preferred 1 2 3
    Tobacco 10-80 25-80 76.6 50 25
    Plasticizer  1-20  1-20 3 pro- 4.6 pro- 5.6 pro-
    pylene pylene pylene
    glycol glycol glycol
    Water Soluble 10-80 20-50 20 30 40
    Polymer
    Filler  0-60  0-30 — 15 29
    Stabilizer 0.1-0.5 0.2-0.4 0.4 0.4 0.4
    • EXAMPLE AN Tobacco Rods
  • A tobacco rod is made from tobacco (54 parts); flavor (2); insoluble fiber (28); CMC (10); artificial sweetener (0.2); and microcrystalline cellulose (30). Water sufficient to form a viscous paste (e.g., 140 parts) is added, and the paste is suitable for processing through an extruder. A suitable extruder would be a Kitchen Aid mixer fitted with a pasta extruder and die. The rod prepared from extrusion through a pasta die can then be used as the forming mandrel for a spiral winding machine and a tobacco containing film can be used to form a wrapping around the tobacco core.
    • EXAMPLE AO Compression Molded Cinnamon Flavored Tobacco Stick
  • TABLE AO1
    Tobacco 23.84%
    Starch 24.09%
    HPMC  4.97%
    Flavor 15.90%
    Filler 19.27%
    Na2CO3  2.98%
    Sweetener  0.99%
    Plasticizer  4.97%
    Water  3.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM100PA2208 (Wolff Cellulosics) 11.16 g
    B700 (Grain Processing Corporation) 55.77 g
    Cinnamon Powder 24.54 g
    Fibersol-2 (Matsutani) 44.61 g
    Na2CO3  6.69 g
    Sucralose (Tate & Lyle)  2.22 g
    Tobacco Powder (average particle size < 80 μm) 55.77 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Glycerin 11.16 g
    Cinnamon Flavor 11.16 g
  • MIX1 was added to the stainless steel mixing bowl of a Kitchen Aid stand mixer. MIX2 was incorporated slowly to the mixture over a time period of 3 minutes with the aid of a paddle attachment at a medium-low speed. Following this addition, 76.92 g of water was added to the mix in the same manner. The resulting paste was allowed to rest at room temperature for a period of 5 minutes.
  • Following the rest period, the paste was fed through a ⅛ inch aperture strand forming unit which had previously been attached to the Kitchen Aid mixer. The strands produced were cut to between 1½ and 2 inches in length, and stored in suitable containers.
  • A set of platens with 2 inch by ¼ inch opposing mold cavities was heated to between 300-330° F. A formed strand was placed in the lower cavity, and the mold was closed by means of a hydraulic press. The mold was allowed to remain closed for a period of 30-60 seconds, providing a means for cooking the starch component of the unit and the release of a portion of the volatile components.
  • The newly formed stick, measuring approximately 2 inches by ⅛ inch, comprised a smooth rigid outer layer, and a rigid foam-like inner mass. The unit disintegrated in the mouth over a period of 1-2 minutes.
    • EXAMPLE AP Compression Molded Apple Flavored Tobacco Stick
  • TABLE AP1
    Tobacco 23.84%
    Starch 24.09%
    HPMC  4.97%
    Flavor  6.45%
    Filler 19.27%
    Na2CO3  2.98%
    Sweetener 10.42%
    Plasticizer  4.97%
    Water  3.00%
  • The following ingredients were weighed and combined in a container of suitable volume:
  • MIX1
    HM100PA2208 (Wolff Cellulosics) 11.16 g
    B700 (Grain Processing Corporation) 55.77 g
    Sucrose 22.29 g
    Fibersol-2 (Matsutani) 44.61 g
    Na2CO3  6.69 g
    Sucralose (Tate & Lyle)  1.11 g
    Malic Acid  2.22 g
    Tobacco Powder (average particle size <80 μm) 55.77 g
  • The resultant mixture was mixed until homogeneous. In a separate container were weighed the following ingredients:
  • MIX2
    Glycerin 11.16 g
    Apple Flavor 12.27 g
  • MIX1 was added to the stainless steel mixing bowl of a Kitchen Aid stand mixer. MIX2 was incorporated slowly to the mixture over a time period of 3 minutes with the aid of a paddle attachment at a medium-low speed. Following this addition, 76.95 g of water was added to the mix in the same manner. The resulting paste was allowed to rest at room temperature for a period of 5 minutes.
  • Following the rest period, the paste was fed through a ⅛ inch aperture strand forming unit which had previously been attached to the Kitchen Aid mixer. The strands produced were cut to between 1½ and 2 inches in length, and stored in suitable containers.
  • A set of platens with 2 inch by ¼ inch opposing mold cavities was heated to between 300-330° F. A formed strand was placed in the lower cavity, and the mold was closed by means of a hydraulic press. The mold was allowed to remain closed for a period of 30-60 seconds, providing a means for cooking the starch and sugar components of the unit and the release of a portion of the volatile components.
  • The newly formed stick, measuring approximately 2 inches by ⅛ inch, comprised a rigid outer layer, and a rigid foam-like inner mass. The unit disintegrated in the mouth over a period of 1-2 minutes.
    • EXAMPLE AQ Extruded Tobacco Sticks
  • TABLE AQ1
    Tobacco 24.34%
    Starch 58.48%
    Na2CO3  3.17%
    Plasticizer  6.34%
    Sweetener  0.79%
    Flavor  4.88%
    Water  2.00%
  • The following ingredients were granulated in a manner similar to granulations utilized for tab production, yielding a tobacco granulation with an approximate moisture of 4.50%:
  •
    B700 (Grain Processing Corporation) 3327.1 g
    B825 (Grain Processing Corporation)  120.0 g
    Na2CO3  181.4 g
    Sucralose (Tate & Lyle)   45.4 g
    Glycerin  362.9 g
    Tobacco Powder (average particle size <80 μm) 1451.5 g
    Water 3473.0 g
  • The tobacco granulation was introduced to the feed section of a Leistritz Micro-18 Twin Screw Extruder 40:1 L/D, which had been configured for co-rotating extrusion with a medium-shear screw design. Feed rates for the extrusion varied between 1-3 pounds per hour. Barrel zone temperatures varied between 75-100° F. Flavor application rates were established at 5 percent of the process flow; hence cinnamon flavor was incorporated to the process downstream of the granulation feed. Venting of volatiles from the extrusion melt was accomplished by incorporating a venting orifice prior to the discharge die of the extruder.
  • Solid tobacco sticks, with an approximate diameter of ⅛ inch, were produced by incorporating a strand die at the discharge end of the extruder. Upon discharge, the flexible tobacco strand was cooled to room temperature on an air-cooling conveyor and became rigid, and was cut to approximately 2½ inches in length. The formed tobacco sticks were placed in a suitable container for storage. The stick disintegrated slowly in the mouth over a period of 5-10 minutes.
  • Gels and Gel Beads. Compositions of the invention may also be made as gels or gel beads. The composition may contain a soluble or insoluble gel containing tobacco. A gel may be used to encapsulate another material, or another material may encapsulate a gel. Gels may be consumed in hydrated forms containing as much as 70% water. The gels may also be dried resulting in parts containing from 1 to 70% water. The amount of water retained in the gel depends on the properties desired in the finished product. It is possible to prepare tobacco containing gels that provide a wide range of organoleptic characteristics.
  • Exemplary gel formats for soluble and insoluble gels include kappa carrageenan, sodium alginate, carboxymethyl cellulose, gelatin, pectin, agar, and starches.
  • Soluble gels containing tobacco can be formed by dissolving the format and at an elevated temperature, e.g., kappa carrageenan at 180° F., and adding the tobacco powder to this solution while continuing vigorous mixing. The hot mixture is then deposited into a mold. Gelatin provides a weak gel at room temperature but firmness and stability can be increased by the addition of agar or starches. Other gelling formats may be used in a similar manner.
  • Insoluble gels are formed by the addition of a cross-linking agent to a predissolved solution or slurry. The solution is deposited into a mold to form the desired shape and sets up through cooling and/or drying. In most cases, it is necessary to maintain the solution at a high temperature, e.g., greater than 180° F., to prevent premature gelation prior to deposition into the mold. After the gel has set into its final shape, the gel can be packaged as is or be further dried to a desired water content. Cross-linking agents include potassium ions for carrageenan; calcium ions for alginates and low methoxy pectins; and trivalent ions such as aluminum for carboxymethyl cellulose. In insoluble gels (i.e., those that do not orally disintegrate), tobacco organoleptic compounds may leach out of the gel as it is held or chewed in the mouth.
  • In one embodiment, gel compositions, e.g., beads, have a solid or liquid center. An exemplary solid center includes smokeless tobacco. An interior liquid may be aqueous, non-aqueous, or heterogeneous, depending on the solubility characteristics of the encapsulating bead wall. Aqueous based liquids are typically encapsulated in a water-insoluble gel that can be disrupted, either mechanically or chemically, in the mouth. The encapsulating gel format may include a polymer and a cross linking agent. Exemplary systems include carrageenan and a monovalent cation (e.g. potassium), alginate or pectin and a divalent ion (e.g. calcium), carboxymethyl cellulose and a trivalent ion (e.g. aluminum), and gelatin and gum arabic. The center may or may not include tobacco.
  • In another embodiment, a water soluble gel encapsulates a non-aqueous filling, e.g., employing ethanol, glycol, vegetable oil, or mineral oil. The water soluble gel and/or the non-aqueous filling may contain tobacco and other ingredients as described herein. Aqueous liquids may also be encapsulated in water soluble gels by the inclusion of additives, e.g., sugars or salts, that sufficiently bind the available water in the filling, thus, preventing the water in the liquid from dissolving the encapsulant. Gel encapsulants also include both hard and soft standard gelatin capsules, which can be filled with liquids or solids.
  • The center of these gel compositions may or may not include tobacco, e.g., as a tobacco slurry. The gel encapsulant also may or may not include tobacco. An exemplary solid center includes smokeless tobacco. The center may also include a color, sweetener, flavor, or flavor masking agent, which may be the same or different from that of the gel encapsulant. The rate of disintegration for the gel encapsulant and center may also be the same or different. Gels with centers typically have a largest dimension of at most 10 mm, e.g., at most 5 mm. Gel beads with liquid centers may be made by introducing droplets of a tobacco/format mixture into a solution causing gelation of the outer surface of the gel bead and retaining the liquid center. Beads can be formed using commercial processes developed by the Morishita Jintan Company and others and referred to generically as “seamless liquid encapsulation” or “seamless capsule technology.” In addition, widely used methods for forming gels of all types including beads have been developed by the suppliers of alginate, carrageenan, and pectin polymers and are well known in the art. The amount of gelation may be controlled, thereby controlling the thickness of the gel encapsulant wall, by varying the concentration of the format, the concentration of the cross-linking agent (e.g., salt), the temperature of the solidifying solution, and the residence time of the gel bead in the solidifying solution. The solution may contain a cross-linking agent or may induce gelation by other means, e.g., a temperature change.
  • Solid gels may be soluble or insoluble. For solid gels, the tobacco and format, with or without additives, are typically mixed, and the format is allowed to gel. Soluble gels can be obtained by using a self gelling gum, such as gellan gum or kappa carrageenan, or by using a polymer, e.g., gelatin, that sets by a change of temperature. Insoluble solid gels are prepared using a cross linking agent. Such soluble and insoluble gels may be made by introducing droplets into an oil bath, e.g., canola oil, or into an aqueous, cross-linking bath to form a spherical shape. They may also be made to pass through the oil into a water based cross-linking solution. Gels may also be made in molds or may be die cut from sheets.
  • In another embodiment, a gel composition is supplied as a dry mixture of format, cross-linking agent (e.g., salt), and tobacco, e.g., in powder form, that is solvated by the consumer prior to use. Solvation causes the gel composition to form a solid, which may be placed in the mouth. Typically, the user places the dry mixture of gel ingredients in a mold and adds solvent, which may be aqueous or non-aqueous. The mixture then quickly hydrates, thereby forming a gel which solidifies in the shape of the mold. The solvating liquid may be used to impart flavor or other taste or mouth feel characteristics to the composition. Alternatively, the consumer may place the dry mixture in the mouth for salvation. The solvent may impart flavor or color to the composition.
    • Gel Examples EXAMPLE AR Gel Beads
  • 100 g of 4% solution of CMC-7MF and 20 g tobacco are combined. Drops are deposited into a 5% solution of water soluble, edible trivalent salt (e.g., AlCl3 or Al2(SO4)3). The surface of droplets is then dried with air drying or gentle oven drying. 100 g of 2% kappa carrageenan and tobacco are combined and heated to 180-190° F. Drops are deposited into a cool solution of 5% KCl. 100 g of 4% medium viscosity sodium alginate and tobacco are combined at 150-170° F. Drops are deposited into a cool solution of 5% edible divalent salt (e.g., CaCl2 or Ca citrate).
  • Beads containing gelatin walls and tobacco slurry centers can be prepared by depositing drops of a cold tobacco slurry (e.g. 60° F.) into a slow moving stream of a dilute, warm gelatin solution (e.g. 130° F.). The warm gelatin coats the outside of the cold droplet and as the gelatin cools and solidifies, it forms a wall of gelatin around the liquid center.
  • Beads are retrieved from the solution by standard means.
    • EXAMPLE AS Orally Disintegrable Solid Gels
  • Combine 10 g gelatin and 90 g water and heat to 140° F. to dissolve gelatin. Add 20 g tobacco and pour into a mold. Strength of the gel can be increased by substituting 6 g of gelatin and 4 g of agar and heating to 190° F. to dissolve.
  • Table AS1 shows exemplary ingredients for fabricating orally disintegrable gels of the invention.
  • TABLE AS1
    Example 1 (parts) Example 2 (parts)
    Gelatin 8 6
    Tobacco 40 40
    Flavor 2 2
    Insoluble Fiber 18 18
    Sweetener 0.2 0.2
    Agar 4 6
    Soluble Fiber 15 15
    Preservative 0.1 0.1
    Water 200 200
    • EXAMPLE AT Exemplary Insoluble Solid Gels
  • The following tables and descriptions show exemplary ingredients for fabricating insoluble gels of the invention, i.e., gels that do not orally disintegrate.
  • TABLE AT1
    Carrageenan Gels
    Parts
    Kappa Carrageenan 8
    Water 240
    Tobacco 54
    Sweetener 0.5
    Soluble Fiber 27
    KCl 1.5
  • The composition is cast at 180° F. after adding KCl and mixing thoroughly.
  • TABLE AT2
    Alginate Gels
    Parts
    Sodium Alginate 10
    Water 240
    Tobacco 54
    Sweetener 0.5
    Soluble Fiber 27
    CaCl2 1
  • The composition is cast after adding CaCl2 at 180° F.
  • TABLE AT3
    Carboxy Methyl Cellulose Gels.
    Parts
    CMC-7MF 10
    Water 240
    Tobacco 54
    Sweetener 0.5
    Soluble Fiber 27
    Al2(SO4)3 1
  • The composition is cast after adding Al2(SO4)3 at 180° F.
    • EXAMPLE AU Soluble Gels
  • 416 grams of aqueous 3.9% kappa carrageenan and 51.0 grams of tobacco were combined. The solution was heated to 180° F-190° F. with stirring, and then the solution was deposited into a mold of the desired shape. Upon cooling, the resultant solid form was removed from the mold and dried to the desired tobacco concentration and gel consistency.
  • In an alternative process, to a 1000 ml stainless steel container equipped with an overhead mixer, mixing bar and hotplate was added 400 ml of water at greater than 200° F. The water was continuously stirred and heated, and 16.0 g of kappa carrageenan (Gelcarin GP 812, FMC Biopolymer) was added over 2 minutes. The resulting mixture was stirred for an additional 20 minutes, or until all kappa carrageenan was dissolved, then tobacco was added to the homogeneous solution, and the resulting mixture was stirred for an additional 2 minutes while maintaining an optimal temperature of 180° F. To this solution was added 0.8 g powdered Sucralose and 7.0 g cinnamon oil (Wixon Industries) with vigorous stirring. Following an additional 1 minute of stirring, the resulting mixture was quickly transferred via pipette (inner diameter 0.5 cm) to Teflon-coated metal molds to obtain the desired shape. After cooling to room temperature, the resulting gels were removed from the molds and air dried at room temperature for 1 h to several days until the desired consistency of the gels was obtained.
  • TABLE AU1
    Carrageenan Gels
    Amount parts
    Kappa Carrageenan 16
    Water 400
    Tobacco 51
    Sweetener 0.8
    Cinnamon Oil 7.0
    • EXAMPLE AV Soluble Gels
  • 100 grams of aqueous 20% gelatin and 33 grams of tobacco were combined. The solution was heated to 140° F-150° F. with stirring, and then the solution was deposited into a mold of the desired shape. Following refrigeration for a few minutes to a few days depending on desired firmness, the resultant solid form was removed from the mold and dried to the desired tobacco concentration and gel consistency.
  • In an alternative process, to a 400 ml stainless steel container equipped with an overhead mixer, mixing bar and hotplate was added 80 ml of water at 140° F. The water was continuously stirred and heated, and 20.0 g of Gelatin (Type A 250 Bloom 40 Mesh, Gum Technology) was added over 2 minutes. The resulting solution was stirred for 5 minutes or until the gelatin was dissolved, then 33 g of tobacco was added in portions over 2 minutes. The resulting mixture was stirred for an additional 1 minute, then 0.3 g powdered Sucralose and 1.0 g of oil of peppermint (rectified, Blend SX 0910001, Essex Labs) were added, and the mixture was vigorously stirred for an additional 1 minute while maintaining a temperature of 140° F. The resulting mixture was transferred via pipette (inner diameter 0.5 cm) to Teflon-coated metal molds to obtain the desired shape. After cooling to room temperature, the resulting gels were removed from the molds, and the gelatin was set by refrigeration at 40° F. for 1 hour to several days depending on desired firmness of the finished piece.
  • TABLE AV1
    Gelatin Gels
    Amount parts
    Gelatin 20
    Water 80
    Tobacco 33
    Sweetener 0.3
    Peppermint Oil 1.0
    • EXAMPLE AW Gel Beads
  • A solution of 4% sodium alginate (Keltone LV, International Specialty Products) was prepared by adding 12 g sodium alginate to 288 g of water heated to boiling, followed by stirring and continuous heating of water on a hot plate for 30 minutes or until the solution was homogeneous (stock solution A). A second solution of 0.50 M disodium hydrogen phosphate was prepared by dissolving 33.5 g disodium hydrogen phosphate heptahydrate in 200 ml of water with warming and stirring of the resulting mixture until the salt was dissolved, followed by adjusting the solution to 250 ml with water. To 100 g of aqueous 0.50 M disodium phosphate was added 20 grams of tobacco and the resulting solution was stirred for 5 minutes (stock solution B). To 50 g of the resulting tobacco slurry (stock solution B) was added 50 ml of aqueous 4% sodium alginate (stock solution A), and the resulting mixture was stirred for 5 minutes. To flavor, 0.20 g of powdered Sucralose and 0.80 g of oil of peppermint (rectified, Blend SX 0910001, Essex Labs) were added to the resulting tobacco/sodium alginate slurry (solution C), and the mixture was stirred for 2 minutes.
  • To prepare gel beads from solution C, a solution of aqueous 5% CaCl2 was prepared by adding 5 g of CaCl2 to 95 g of water with stirring until the calcium chloride was dissolved (solution D). Solution C was then added drop by drop to solution D by pipette from a height of 10 inches. The outer coat of each droplet solidified upon exposure to solution D, forming a solid gel-like outer coat with a liquid center that sank to the bottom of the calcium chloride solution. The gel beads were allowed to remain in the calcium chloride solution for 2-4 minutes, removed, and allowed to air dry for several minutes.
  • Solution A
    Amount parts
    Sodium alginate 12
    Water 288
  • Solution B
    Amount parts
    Disodium hydrogen phosphate heptahydrate 13.4
    Water 86
    Tobacco 20
  • Solution C
    Amount parts
    Solution A 50
    Solution B 50
    Sucralose 0.2
    Oil of peppermint 0.8
  • Solution D
    Amounts parts
    Calcium chloride 5
    Water 95
  • Consumable Units. Compositions of the invention may also be fabricated as consumable units. These units may be packaged as edible or inedible materials. In one embodiment, the consumable unit includes tobacco (e.g., smokeless tobacco) or a tobacco composition, e.g., flakes, tabs, beads, granules, or other tobacco composition as described herein, and a wrapping, e.g., a pouch. The wrapping, in one embodiment, may act as an adhesive to hold the composition together, e.g., to hold a plurality of tabs, beads, flakes, etc. together. Alternatively, the wrapping may enclose the composition, e.g., loose tabs, beads, flakes, etc. The composition may also include a liquid, e.g., a tobacco slurry. The wrapping may or may not be orally disintegrable. Orally disintegrable wrappings may be used to enclose aqueous or non-aqueous liquids. When an aqueous liquid is employed with a water soluble wrapping, the liquid includes an agent to prevent dissolution of the wrapping. Exemplary agents include sugars, salts, and other hydrophilic agents capable of binding water sufficiently to reduce water activity to a level at which the water is no longer available to interact with and dissolve the water soluble wrapping. The wrapping may also enclose a moldable tobacco composition that conforms to the mouth or holds its shape in the mouth. In one embodiment, an orally disintegrable wrapping encloses smokeless tobacco, e.g., dry snuff or tobacco, that is perceived as soluble (e.g., less than 80 .mu.m particle size). Orally disintegrable smokeless tobacco compositions may be introduced to consumable portion packs which have been formed on continuous thermoforming or horizontal form/fill/seal equipment or other suitable packaging equipment using edible films (which may or may not contain tobacco) made in accordance with the subject technology. Consumable units may also contain two or more, individually wrapped portions of tobacco, e.g., all contained within a larger package, one containing the other portions, or none of the portions contained with another. When multiple portions are used, any two may have the same or different flavor, color, form of tobacco, or rate of disintegration.
  • Exemplary wrapping materials include films formed from film compositions based on formats such as HPMC, CMC, pectin, alginates, pullulan, and other commercially viable, edible film forming polymers, such as those described herein. Other wrapping materials may include pre-formed capsules made from gelatin, HPMC, starch/carrageenan, or other commercially available materials. Such wrapping materials may include tobacco as an ingredient. Wrappings which are not orally disintegrable may include woven or nonwoven fabrics; coated or uncoated paper; or of perforated or otherwise porous plastic films. Wrappings may also be colored. Exemplary consumable units include those formed by any method used in commercial packaging, e.g., blister pack and stik-pak (e.g. a small package formed on a vertical form/fill/seal packaging machine).
    • Consumable Unit Examples
  • The following description provides exemplary ingredients for fabricating consumable units of the invention.
    • EXAMPLE AX Films or Capsules Encapsulating Beads, Powders, Tabs, etc
  • Any of the compositions described herein can be encapsulated with a film or capsule. The encapsulant may provide color, stability (e.g., during storage, handling or consumption), or organoleptic properties (e.g., flavor, sweetness, smell, or mouth feel). The encapsulant may also contain tobacco.
  • A vacuum forming tool is constructed which has a series of cavities which are shaped as circles with diameter of ¾th inch and depth of 3⅜th inch. Films as described herein are prepared with and without tobacco as an ingredient. These films are introduced to a vacuum forming machine with a vacuum forming tool. The films are placed over heating elements and warmed to a temperature of 200° F. The films are then quickly placed on the vacuum forming tool, and a vacuum is pulled to draw the film into the cavities. The films are then cooled to set the shapes. Tobacco powder is then introduced into each cavity. A second sheet of film prepared with or without tobacco is selected and coated (by wiping the surface of the film with a wet felt) with a thin layer of water to create a sticky, adhesive surface. The sticky surface is placed on top of the formed sheet wherein each cavity is filled with a tobacco product. The sheets are pressed together to form closed consumable units. Each cavity is then cut out of the vacuum formed sheet to create individual units. A unit is placed in the mouth wherein the film disintegrates and disperses the tobacco in the oral cavity.
    • EXAMPLE AY Tobacco Particles in a Water-Soluble Bag
  • Smokeless tobacco particles or powder, e.g., snuff, may be placed in a water-disintegrable bag. When placed in the mouth, the bag disintegrates after a specified period of time. The bag may contain a single serving of tobacco. It may also contain additional additives as described herein. The tobacco may also adhere to itself as a moldable plug once the wrapping disintegrates.
  • The disintegrable bag may be formed using films such as those described herein. The film can be formed into a bag using commercially available packaging equipment such as vertical form/fill/seal machines (e.g. stick pack machines), horizontal form/fill/seal machines, flow wrappers, thermoformers (blister pack machines), and other equipment common to the art.
    • EXAMPLE AZ Tobacco Particles in Film/Fabric Laminations
  • Smokeless tobacco particles or powder may be placed in a bag that is formed from an open or highly porous wrapping material, e.g., fabrics, paper or plastic films, which has been laminated to a water-soluble wrapping film. The water-soluble film layer provides protection for the tobacco contents and prevents the tobacco from sifting through the openings of the insoluble material during storage and handling. Once the bag is placed in the mouth, the water-soluble film layer dissolves or disintegrates.
    • EXAMPLE BA Film Pouches Containing Tobacco
  • Films as described herein in Film Examples N, O, P, and Q were used to manufacture tobacco containing pouches. Individual units approximately 1 inch by 1¼ inches were cut from each sheet of manufactured film. The unit was folded over lengthwise and heat-sealed using a Clamco Model 210-8E impulse sealer. One end of the formed unit was also sealed in the same manner. A flavored tobacco granulation was fed to the interior of the formed pouch, and the final seal was made as described to seal the pouch. The tobacco containing pouch disintegrated in the mouth between 20 seconds and 1 minute, releasing the contents of the pouch.
  • Insoluble Matrices. Tobacco may also be coated onto or entrapped within an insoluble matrix. Tobacco can be dispersed to form a slurry in an aqueous solution of a format, as when forming a film; this slurry can be coated on to an insoluble matrix or can be used to saturate a porous insoluble matrix. The slurry may then be converted into a soluble or insoluble gel or it may simply be dried to form a coating. When a portion of this coated/saturated insoluble matrix is placed in the mouth, leaching of organoleptic components occurs through dissolution, chewing, or other means. In one embodiment, tobacco in a format is introduced into a porous matrix, e.g., an open. cell polyurethane foam or a high loft polyester nonwoven fabric. The insoluble matrix may be placed wholly in the mouth, or it may be disposed on a stick or other handle, which remains partially outside the mouth during consumption. In another embodiment, tobacco in a format is blended with an incompatible liquid, e.g., a dispersion of carnauba wax in water, deposited in a mold, and quickly cooled to cause a phase separation such that the tobacco slurry is disposed within a waxy structure. These matrices may also be chewable.
  • Formats for use in retaining the tobacco in the insoluble matrix include any of the film forming polymers described herein; any of the gelling systems described herein and any of the coating materials described herein.
    • Insoluble Matrix Examples EXAMPLE BB Polyurethane Foam A
  • A film forming composition which contains finely ground tobacco as described herein is used to saturate a piece (e.g., 12 inches by 12 inches by 1 inch) of open cell polyurethane foam (Stephenson & Lawyer, Inc. Grand Rapids, Mich.). The saturated foam is placed on a metal tray and is put into an air circulating laboratory oven preset at 175° F. for one hour. When the foam is removed from the oven, the tobacco containing composition has dried to form a coating that uniformly covers all the interstices of the polyurethane foam. The coated foam is cut into pieces of a size (e.g., 1 inch by 1 inch by 1 inch) suitable to place in the mouth. After use, the polyurethane foam is removed from the mouth and discarded.
    • EXAMPLE BC Polyurethane Foam B
  • A sodium alginate and calcium salt gel composition containing finely ground tobacco as described herein is used to saturate an open cell polyurethane foam (e.g., 12 inches by 12 inches by 1 inch). The alginate gel is maintained at a temperature of 180° F. to prevent premature setting of the gel. The hot alginate gel is poured on to the polyurethane foam, which is placed on a metal tray and then quickly cooled in a refrigerator at 40° F. to set the gel. The foam is then placed in a laboratory oven preset at 175° F. for 10 minutes to surface dry the gel and to reduce moisture content to 50% based on dry weight of the gel. The partially dried gel fills voids in the polyurethane foam. The foam is cut into pieces and is placed in the mouth. A further example of gels in an insoluble matrix is obtained by drying the gel to a lower moisture content (e.g., 10% based on dry weight of the gel). The tobacco containing gel exhibits a firm, rubbery texture within the foam matrix and rehydrates slowly when placed in the mouth and chewed. After use, the polyurethane foam is removed from the mouth and discarded.
  • Hollow Shapes. As discussed above, films or thin sheets of material may be wrapped, extruded, blow molded, or otherwise shaped to form tubes, straws, or other hollow shapes. Exemplary film or sheet materials are disclosed in the film section herein. Such hollow shapes may be single or multilayer. When multiple layers are used, some may contain tobacco while others may contain colors, flavors, sweeteners, or other compounds as described herein. Different layers may also be employed for stability during handling or to control disintegration during consumption. A spiral wrapped hollow shape, e.g., tube or straw, may require an adhesive (e.g., CMC or guar) to keep from unraveling. The layers in a multilayer hollow shape may contain the same or different color or flavor, and such layers may disintegrate at the same or different rates. As with films, tobacco may also be disposed within one or more layers or may be disposed between layers in a sandwich arrangement. The hollow shape may also include a disintegrant to hasten disintegration.
  • The compositions described above may be hollow or filled. The filling may include tobacco, a flavor, sweetener, flavor masking agent, or a color. The flavor or color of the filling may be the same or different than the hollow shape. The filling is typically a gel (solid or flowable) but may also be mechanically rigid or may be composed of a powder or other product form. Exemplary filling materials include gels as described herein. A hollow shape may also be filled with a composition that disintegrates more rapidly than the shape, e.g., to provide tobacco at different times based on the rate of disintegration.
  • In one embodiment, a tobacco core (e.g., formulated with tobacco and a format) can be extruded from a single or twin screw extruder into a coextrusion die. In a separate single or twin screw extruder, a water soluble, thermoplastic outer layer (e.g., formulated with a format and a flavor) can be introduced to the coextrusion die to create a coated rod. A typical thermoplastic outer layer can be provided with a formulation based on hydroxypropyl cellulose (HPC) which is extruded at a temperature between 220-370° F. In addition, a rigid extruded tobacco rod may become a core which is encased in a wrapped film.
  • In one example, a thermoplastic formulation containing hydroxypropyl cellulose, tobacco, flavor, and sweetener can be blow molded to form a hollow shape.
  • In another example, films as described herein were additionally used to manufacture spiral-wound straws and/or sticks. Strips of film approximately 10 inches by ¾ inch were cut from each sheet of manufactured film. A strip of paper of equal size was cut and wound spirally around a 3/16 inch diameter stainless steel mandrel. The paper was secured about the mandrel with tape on each end. A strip of film was wound spirally about the paper in the same fashion, overlapping each spiral by 1/16 inch. At each overlap the film strip was glued to itself with a 30% solution of gum arabic. The process was repeated with two additional plies of film. The mandrel and newly formed spiral-wound film straw/stick was placed in a side-swept forced air oven at 75° C. (VWR model 1330FM) for 15 minutes to dry. Upon removal from the oven, the spiral-wound straw/stick was removed from the mandrel, and the paper “core” removed from the interior of the straw/stick. The resultant straw/stick was cut into various sizes.
  • For example, spiral-wound straw/stick products were prepared using tobacco containing films as described in Example N. Flavored Tobacco Film for Sticks/Wraps/Pouches/Vacuum Forming. Straw/stick products containing one layer, two layers and three layers of Example N films were prepared as described. When placed in the mouth, the straw/stick disintegrated gradually over a period of 1 to 5 minutes.
  • In another example, straw/stick products were prepared using two layers of film as described in Example N. A third layer of film, prepared as described in Example O. Flavored/Colored Film for Sticks/Wraps/Pouches, was provided on the top or outside of the straw/stick. The film from Example O was red in color, cinnamon flavored and did not contain tobacco. This straw/stick, when placed in the mouth, disintegrated gradually over a period of 1 to 5 minutes
  • In another example, straw/stick products were prepared using three layers of film as described in Example P. Peach Flavored Film for Sticks/Wraps/Pouches. The film from Example P contained tobacco powder and peach puree. The straw/stick was prepared as above. The straw/stick disintegrated gradually over a period of 1 to 5 minutes.
  • In yet another example, straw/stick products were prepared using three layers of film as described in Example N and Example Q. One layer of tobacco containing film prepared in Example N was used. A second layer of opaque, white film prepared as in Example Q was wound over the first layer of film and offset by ⅛th inch. A third layer of tobacco containing film as prepared in Example N was wound over the second layer and again was offset by ⅛th inch. The affect was to provide a spiral-wound straw/stick with a striped appearance. The straw/stick, when placed in the mouth, disintegrated gradually over a period of 1 to 5 minutes.
  • In another example, hollow tobacco straws, with diameters ranging from ⅛ to ¼ inch, were produced by methods similar to those employed in Example AQ of Shaped Parts; however, a tube die was employed in the manufacture of the straw. The straw(s) disintegrated slowly in the mouth over a period of 5-10 minutes. Similar articles may be manufactured with a filling, with methods known in the art (i.e. co-extrusion).
    • D. Modifications
  • Any tobacco composition described herein may be modified in various ways. For example, a composition may be coated in single or multiple layers. Such coatings are employed, e.g., for handling, disintegration rate, taste, and color. Exemplary coatings include HPMC. Coatings or decorative patterns may be applied to the surface of the film using processes known in the art, e.g., spraying, brushing, roll coating, doctor bar casting, slot coating, extrusion coating, hot melt deposition, depositing particles or flakes, and other typical methods. Coatings may be matte or glossy. A coating may contain a color, flavor, sweetener, or flavor masking agent, as described herein. The color, flavor, sweetener, or flavor masking agent in the coating may be same or different as the underlying composition. In addition, multiple coatings may also contain the same or different color, flavor, sweetener, or flavor masking agent. The coating may also disintegrate at a different rate than the underlying composition. For example, a coating may disintegrate faster than the underlying composition to provide a burst of flavor or other organoleptic components. An orally disintegrable coating may also be placed on a composition that does not disintegrate orally. A coating that does not disintegrate orally may be placed on a composition that disintegrates orally, and such a coating may be removed, e.g., by chewing. Coatings may also be employed to prevent evaporation of volatile components in a composition and to prevent mechanical maceration of a composition prior to use. A coating may also contain tobacco.
  • Patterns may also be printed on the surfaces of compositions. Printing patterns also encompasses dusting or sprinkling compounds on the surface of a composition. The pattern may be random or in a design, e.g., a logo. All printing processes known in the art, e.g., offset, flexographic, gravure, ink jet, laser, screen printing, and other typical methods may be used. The printed pattern may or may not contain a color, flavor, sweetener, or flavor masking agent, as described herein. The color, flavor, sweetener, or flavor masking agent in the pattern may be same as or different from the underlying composition. In addition, multiple patterns may also contain the same or different color, flavor, sweetener, or flavor masking agent. The printed pattern may also contain tobacco, e.g., up to 1-99%, preferably 10-50%. Such a pattern may contain more tobacco, percentage-wise or in an absolute sense, than the underlying composition.
  • Flakes may also be added to compositions described herein. Flakes may be mixed into the composition, may be placed within a void in the composition, or may be placed on the surface, e.g., and adhered by a coating. Flakes may or may not contain a color, flavor, sweetener, or flavor masking agent, as described herein. The color, flavor, sweetener, or flavor masking agent in the flakes may be same or different as the underlying composition. In addition, multiple flakes may also contain the same or different color, flavor, sweetener, or flavor masking agent. Flakes may also contain tobacco, e.g., up to 99%, preferably up to 50%. Flakes may be made by standard film forming technology as described herein. Flakes may contain more tobacco, percentage-wise or in an absolute sense, than the underlying composition.
  • Once the printed, coated, or decorated film has been prepared, an additional layer of film may be applied to cover, protect and seal the printed, coated or decorated surface.
  • Compositions of the invention may be shaped in various forms, e.g., plants and geometric shapes (e.g., round, square, rectangular, triangular, oval, octagonal, and the like). In addition, compositions may contain a pattern in relief (positive or negative) on the surface. Such a pattern may be a design, such as a logo.
  • Composite compositions, i.e., compositions including two or more of the different types of products described herein, are also contemplated by the invention. For example, a shaped part may contain regions of gel compositions, e.g., having a variety of flavors. In another example, a tab may be surrounded by a gel. Composite compositions may also have different rates of disintegration.
    • E. Packaging
  • Individual compositions will be packaged as appropriate for the contents of the composition. Preferably, the compositions are stored in a waterproof case and are stable between 40 and 120° F. Compositions are typically dry, flexible, and non-adhesive while in storage. Alternatively, compositions may be packaged using non-stick barriers, e.g., plastic film or paper, between servings. Compositions may also be provided in a bulk form, from which individual servings are separated.
  • In another embodiment, the package is water impermeable and water insoluble, and tobacco, e.g., in liquid, slurry, or flowable gel form, is disposed within the package, e.g., a squeezable plastic package, a bellows, or a spray bottle, and is capable of being dispensed into the mouth from the package. The bellows may be compressed for oral use. Solutions or slurries are prepared for use in a plastic bellows container or other similar consumer packaging containers wherein the liquid is injected into the mouth by squeezing the package. Thixotropic polymers are combined with tobacco and other ingredients to prepare higher viscosity solutions suitable for use in other containers. Tobacco particles can be of greater size, but must still be small enough to pass through the orifice of the container. For spray bottles, a stable tobacco slurry is contained in the bottle; tobacco particles are sized to be able to pass through a spray nozzle without blocking the orifice; and the tobacco slurry is sprayed directly in the oral cavity. Liquid sprays are prepared by dissolving a thixotropic polymer such as xanthan, gellan or dextran in water and suspending tobacco particles in a low viscosity (e.g., <50 centipoise) solution. Other compounds, such as flavor, sweetener and dispersant, can be added to the solution. The tobacco particles are ground to a particle size (e.g., <80 microns) to permit the homogeneous solution to pass through the orifice of a spray bottle. Other packages may be otherwise squeezed or used to expel the tobacco into the oral cavity.
    • F. Solutions
  • The following tobacco solutions may be included in any composition described herein.
    • EXAMPLE BD Sprayable Solution
  • A solution is prepared by mixing 0.2 grams of xanthan (Kelzan from C. P. Kelco) in 78.6 grams of cool water with vigorous mixing for 30 minutes. To this solution is added 20 grams of finely ground tobacco, 0.2 grams of sucralose, and 2 grams of cinnamon flavor while continuing to mix vigorously. The solution viscosity is adjusted with water to a viscosity of 50 centipoise.
    • EXAMPLE BE Thick Solution
  • A solution is prepared by mixing 1 gram of xanthan (Kelzan from C. P. Kelco) with 76.8 grams of cool water while mixing vigorously for 30 minutes. To this is added 20 grams of fine tobacco, 0.2 grams of sucralose and 2 grams of cinnamon flavor while continuing to mix vigorously. Solution viscosity is 1,500 centipoise.
    • EXAMPLE BF Paste
  • A paste is prepared by adding 2 grams of a medium viscosity carboxymethyl cellulose (CMC 7MF from Hercules, Inc.) to a mixture of 35.8 grams of cool water and 40 grams of glycerine with vigorous mixing for 30 minutes. To this mixture is added 20 grams of fine tobacco powder, 0.2 grams of sucralose, and 2 grams of cinnamon flavor. A thick paste is prepared which is highly shear sensitive. This paste can be introduced to a tube or other squeezable package where the shear force from squeezing reduces the viscosity to permit flow of the paste.
    • OTHER EMBODIMENTS
  • The description of the specific embodiments of the invention is presented for the purposes of illustration. It is not intended to be exhaustive nor to limit the scope of the invention to the specific forms described herein. Although the invention has been described with reference to several embodiments, it will be understood by one of ordinary skill in the art that various modifications can be made without departing from the spirit and the scope of the invention, as set forth in the claims. All patents, patent applications, and publications referenced herein are hereby incorporated by reference.
  • Other embodiments are within the claims.

Claims (27)

1. (canceled)
2. A smokeless tobacco composition comprising:
a gel format; and
a plurality of tobacco particles, the plurality of tobacco particles having an average particle size of less than or equal to about 250 μm.
3. The smokeless tobacco composition of claim 2, wherein the gel format comprises kappa carrageenan, sodium alginate, carboxymethyl cellulose, gelatin, pectin, agar, a starch, a sub-combination thereof, or a combination thereof.
4. The smokeless tobacco composition of claim 2, wherein the gel format comprises a polymer.
5. The smokeless tobacco composition of claim 4, wherein the polymer includes carrageenan.
6. The smokeless tobacco composition of claim 4, wherein the polymer includes alginate.
7. The smokeless tobacco composition of claim 4, wherein the polymer includes carboxymethyl cellulose.
8. The smokeless tobacco composition of claim 4, wherein the polymer includes pectin.
9. The smokeless tobacco composition of claim 2, wherein the gel format comprises a cross-linking agent.
10. The smokeless tobacco composition of claim 9, wherein the cross-linking agent comprises a monovalent cation.
11. The smokeless tobacco composition of claim 9, wherein the cross-linking agent comprises a divalent cation.
12. The smokeless tobacco composition of claim 9, wherein the cross-linking agent comprises a trivalent cation.
13. The smokeless tobacco composition of claim 9, wherein the cross-linking agent comprises a divalent cation.
14. The smokeless tobacco composition of claim 2, further comprising:
a core, the gel format encapsulating the core.
15. The smokeless tobacco composition of claim 14, wherein the core comprises a solid.
16. The smokeless tobacco composition of claim 14, wherein the core comprises a liquid.
17. The smokeless tobacco composition of claim 16, wherein the liquid is an aqueous liquid.
18. The smokeless tobacco composition of claim 16, wherein the liquid is a non-aqueous liquid.
19. The smokeless tobacco composition of claim 16, wherein the liquid comprises ethanol, glycol, vegetable oil, mineral oil, a sub-combination thereof, or a combination thereof.
20. The smokeless tobacco composition of claim 14, wherein the core comprises the plurality of tobacco particles.
21. The smokeless tobacco composition of claim 14, wherein the gel format includes a first flavor and the core includes a second flavor, the second flavor being different from the first flavor.
22. The smokeless tobacco composition of claim 2, wherein the gel format comprises a plurality of discrete regions, each region of the plurality of discrete regions including a flavorant, a colorant, or both a flavorant and a colorant.
23. The smokeless tobacco composition of claim 22, wherein the plurality of discrete regions includes a first region and a second region, the first region is concentric to the second region.
24. The smokeless tobacco composition of claim 2, wherein the smokeless tobacco composition is configured to be wholly received in a mouth.
25. The smokeless tobacco composition of claim 2, wherein the smokeless tobacco composition is secured to a holding device, the holding device comprising at least one of wood, paper, plastic, metal, a composite, a sub-combination thereof, or a combination thereof.
26. A smokeless tobacco composition comprising:
a non-solvated mixture including,
a polymer,
a cross-linking agent, and
a plurality of tobacco particles having an average particle size of less than or equal to about 250 μm, the polymer and the cross-linking agent being configured to be solvated to form an insoluble gel.
27. A smokeless tobacco kit comprising:
a non-solvated mixture including,
a polymer,
a cross-linking agent, and
a plurality of tobacco particles having an average particle size of less than or equal to about 250 μm, and
a mold, wherein the non-solvated mixture is configured to be solvated in the mold to form an insoluble gel in a shape of the mold.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020207736A1 (en) * 2019-04-08 2020-10-15 Philip Morris Products S.A. Method of manufacturing an aerosol-generating film

Families Citing this family (451)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700851B2 (en) * 2001-11-13 2010-04-20 U.S. Smokeless Tobacco Company Tobacco nicotine demethylase genomic clone and uses thereof
US7812227B2 (en) 2001-11-13 2010-10-12 U.S. Smokeless Tobacco Company Cloning of cytochrome p450 genes from nicotiana
US7700834B2 (en) * 2001-11-13 2010-04-20 U.S. Smokless Tobacco Company Nicotiana nucleic acid molecules and uses thereof
US8592663B2 (en) * 2001-11-13 2013-11-26 U.S. Smokeless Tobacco Company Llc Tobacco nicotine demethylase genomic clone and uses thereof
US10266836B2 (en) 2001-11-13 2019-04-23 U.S. Smokeless Tobacco Company Llc Tobacco nicotine demethylase genomic clone and uses thereof
US7638154B2 (en) * 2003-01-21 2009-12-29 Hap International, Inc. Pan spray formulation and delivery system
US8637731B2 (en) * 2003-10-16 2014-01-28 U.S. Smokeless Tobacco Company Nicotiana nucleic acid molecules and uses thereof
ZA200602938B (en) 2003-10-16 2008-06-25 Us Smokeless Tobacco Company Cloning of cytochrome p450 genes from Nicotiana
AU2004289248B2 (en) 2003-11-07 2012-05-03 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8586837B2 (en) 2004-04-29 2013-11-19 U.S. Smokeless Tobacco Company Llc Nicotiana nucleic acid molecules and uses thereof
US20060185686A1 (en) * 2004-08-23 2006-08-24 Lawrence Robert H Jr Nicotiana diversity
JP2008510486A (en) * 2004-08-23 2008-04-10 ユーエス スモークレス タバコ カンパニー Tobacco with diversity
US20070199097A1 (en) * 2004-09-03 2007-08-23 U.S. Smokeless Tobacco Company Tobacco plants having a mutation in a nicotine demethylase gene
ATE530656T1 (en) 2005-02-23 2011-11-15 Univ North Carolina State MODIFICATION OF ALKALOID CONTENT IN TOBACCO THROUGH MODIFICATION OF SPECIFIC CYTOCHROME P450 GENES.
US20070000505A1 (en) * 2005-02-24 2007-01-04 Philip Morris Usa Inc. Smoking article with tobacco beads
US7992575B2 (en) * 2005-02-28 2011-08-09 U.S. Smokeless Tobacco Company Use of chlorate, sulfur or ozone to reduce tobacco specific nitrosamines
US9044049B2 (en) 2005-04-29 2015-06-02 Philip Morris Usa Inc. Tobacco pouch product
CN101222861B (en) 2005-04-29 2010-09-08 菲利普莫里斯生产公司 Tobacco pouch product
US20160345631A1 (en) 2005-07-19 2016-12-01 James Monsees Portable devices for generating an inhalable vapor
US11647783B2 (en) 2005-07-19 2023-05-16 Juul Labs, Inc. Devices for vaporization of a substance
US9675109B2 (en) * 2005-07-19 2017-06-13 J. T. International Sa Method and system for vaporization of a substance
US20070062549A1 (en) * 2005-09-22 2007-03-22 Holton Darrell E Jr Smokeless tobacco composition
WO2007037962A1 (en) * 2005-09-22 2007-04-05 R.J. Reynolds Tobacco Company Smokeless tobacco composition
US7861728B2 (en) * 2006-02-10 2011-01-04 R.J. Reynolds Tobacco Company Smokeless tobacco composition having an outer and inner pouch
US8685478B2 (en) 2005-11-21 2014-04-01 Philip Morris Usa Inc. Flavor pouch
US8053008B2 (en) 2005-11-21 2011-11-08 Philip Morris Usa Inc. Method of manufacturing flavor pouches
US7918231B2 (en) * 2006-01-31 2011-04-05 U.S. Smokeless Tobacco Company Llc Tobacco articles and methods
US7913699B2 (en) 2006-01-31 2011-03-29 U.S. Smokeless Tobacco Company Llc Tobacco articles and methods
US7819124B2 (en) * 2006-01-31 2010-10-26 U.S. Smokeless Tobacco Company Tobacco articles and methods
US7810507B2 (en) * 2006-02-10 2010-10-12 R. J. Reynolds Tobacco Company Smokeless tobacco composition
US7946296B2 (en) * 2006-05-26 2011-05-24 Philip Morris Usa Inc. Dissolvable tobacco film strips and method of making the same
US20080017208A1 (en) * 2006-07-20 2008-01-24 Elberto Berdut Teruel Novel tobacco substitute
US20080029117A1 (en) * 2006-08-01 2008-02-07 John-Paul Mua Smokeless Tobacco
US20080029116A1 (en) * 2006-08-01 2008-02-07 John Howard Robinson Smokeless tobacco
JP5941609B2 (en) * 2006-08-01 2016-06-29 アール・ジェイ・レノルズ・タバコ・カンパニーＲ．Ｊ．Ｒｅｙｎｏｌｄｓ Ｔｏｂａｃｃｏ Ｃｏｍｐａｎｙ Smokeless tobacco
WO2008049088A2 (en) 2006-10-21 2008-04-24 Rollins Aaron M D Guidewire manipulation device
US9032971B2 (en) 2006-11-15 2015-05-19 Philip Morris Usa Inc. Moist tobacco product and method of making
US8319011B2 (en) * 2006-12-15 2012-11-27 U.S. Smokeless Tobacco Company Llc Tobacco plants having reduced nicotine demethylase activity
US9370160B2 (en) 2006-12-15 2016-06-21 Altria Client Services Llc Tobacco inbred plants ALBEX1F and ALBEX1MS
US11332753B2 (en) 2006-12-15 2022-05-17 U.S. Smokeless Tobacco Company Llc Tobacco plants having reduced nicotine demethylase activity
US20080156338A1 (en) * 2006-12-28 2008-07-03 Philip Morris Usa Inc. Sterilized moist snuff and method
GB0700889D0 (en) * 2007-01-17 2007-02-21 British American Tobacco Co Tobacco, tobacco derivative and/or tobacco substitute products, preparation and uses thereof
EP3689274A1 (en) 2007-02-05 2020-08-05 Boston Scientific Limited Thrombectomy system
BRPI0807783A2 (en) 2007-02-23 2014-06-24 Us Smokeless Tobacco Co SMOKE-FREE TOBACCO COMPOSITION, METHODS FOR PRODUCING PLANT VARIETY AND FOR PREPARING TOBACCO WITH REDUCED AMARGOR, TOBACCO PLANT, AND CURED TOBACCO.
US8616221B2 (en) * 2007-02-28 2013-12-31 Philip Morris Usa Inc. Oral pouch product with flavored wrapper
US20080276948A1 (en) * 2007-05-09 2008-11-13 Philip Morris Usa Inc. Chewing article for oral tobacco delivery
US8356606B2 (en) 2007-06-01 2013-01-22 Philip Morris Usa Inc. Production of micronized encapsulated tobacco particles for tobacco flavor delivery from an oral pouch
US8029837B2 (en) * 2007-06-08 2011-10-04 Philip Morris Usa Inc. Chewable pouch for flavored product delivery
US20080308115A1 (en) * 2007-06-08 2008-12-18 Philip Morris Usa Inc. Oral pouched products including tobacco beads
US20080302376A1 (en) * 2007-06-08 2008-12-11 Philip Morris Usa Inc. Smoking article with controlled flavor release
WO2009007854A2 (en) * 2007-06-08 2009-01-15 Philip Morris Products S.A. Oral pouch product including soluble dietary fibers
US9888712B2 (en) 2007-06-08 2018-02-13 Philip Morris Usa Inc. Oral pouch products including a liner and tobacco beads
WO2009004488A2 (en) 2007-06-08 2009-01-08 Philip Morris Products S.A. Capsule clusters for oral consumption
WO2009010875A2 (en) * 2007-07-16 2009-01-22 Philip Morris Products S.A. Oral delivery pouch product with coated seam
WO2009010884A2 (en) 2007-07-16 2009-01-22 Philip Morris Products S.A. Tobacco-free oral flavor delivery pouch product
WO2009010881A2 (en) * 2007-07-16 2009-01-22 Philip Morris Products S.A. Oral pouch products with immobilized flavorant particles
US8950408B2 (en) * 2007-07-16 2015-02-10 Philip Morris Usa Inc. Oral pouch product having soft edge
US8119173B2 (en) 2007-07-16 2012-02-21 Philip Morris Usa Inc. Method of flavor encapsulation through the use of a drum coater
US7946295B2 (en) 2007-07-23 2011-05-24 R. J. Reynolds Tobacco Company Smokeless tobacco composition
EP2179666B1 (en) 2007-07-23 2012-08-29 R.J.Reynolds Tobacco Company Smokeless Tobacco Compositions And Methods For Treating Tobacco For Use Therein
US8061362B2 (en) 2007-07-23 2011-11-22 R. J. Reynolds Tobacco Company Smokeless tobacco composition
US8312886B2 (en) * 2007-08-09 2012-11-20 Philip Morris Usa Inc. Oral tobacco product having a hydrated membrane coating and a high surface area
US9271524B1 (en) 2007-09-07 2016-03-01 U.S. Smokeless Tobacco Company Tobacco having reduced tobacco specific nitrosamine content
US9125434B2 (en) 2007-10-11 2015-09-08 Philip Morris Products S.A. Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet
AU2014202355B2 (en) * 2007-10-11 2016-06-02 Philip Morris Products S.A. Method for making a tobacco product
CN107048483A (en) * 2007-10-11 2017-08-18 菲利普莫里斯生产公司 Smokeless tobacco product
US20090098192A1 (en) * 2007-10-11 2009-04-16 Fuisz Richard C Extrudable and Extruded Compositions for Delivery of Bioactive Agents, Method of Making Same and Method of Using Same
EP2220231B1 (en) 2007-11-12 2017-10-11 North Carolina State University Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes
US8336557B2 (en) 2007-11-28 2012-12-25 Philip Morris Usa Inc. Smokeless compressed tobacco product for oral consumption
US8991402B2 (en) 2007-12-18 2015-03-31 Pax Labs, Inc. Aerosol devices and methods for inhaling a substance and uses thereof
SE0800058L (en) * 2008-01-10 2009-07-11 British American Tobacco Co Tobacco product for oral use
EP2234711B1 (en) 2008-01-25 2017-11-01 RJ Reynolds Tobacco Company Process for manufacturing breakable capsules useful in tobacco products
US8469037B2 (en) 2008-02-08 2013-06-25 Philip Morris Usa Inc. Pre-portioned moist product and method of making
US20100018539A1 (en) * 2008-07-28 2010-01-28 Paul Andrew Brinkley Smokeless tobacco products and processes
WO2010044736A1 (en) * 2008-10-14 2010-04-22 Mcneil Ab Multi portion intra-oral dosage form and use thereof
US20100116281A1 (en) * 2008-11-07 2010-05-13 Jerry Wayne Marshall Tobacco products and processes
KR101342839B1 (en) 2008-11-12 2013-12-17 니뽄 다바코 산교 가부시키가이샤 Wrapping paper for low ignition propensity cigarette
US9155772B2 (en) 2008-12-08 2015-10-13 Philip Morris Usa Inc. Soft, chewable and orally dissolvable and/or disintegrable products
US8377215B2 (en) 2008-12-18 2013-02-19 Philip Morris Usa Inc. Moist botanical pouch processing
CN102325472B (en) 2008-12-19 2015-07-29 美国无烟烟草有限责任公司 The method of tobacco particle and production tobacco particle
US9167835B2 (en) 2008-12-30 2015-10-27 Philip Morris Usa Inc. Dissolvable films impregnated with encapsulated tobacco, tea, coffee, botanicals, and flavors for oral products
US9027567B2 (en) * 2008-12-30 2015-05-12 Philip Morris Usa Inc. Oral pouch product with multi-layered pouch wrapper
WO2010078413A1 (en) 2008-12-31 2010-07-08 Apinee, Inc. Preservation of wood, compositions and methods thereof
BRPI0923851A2 (en) * 2008-12-31 2015-07-28 Us Smokeless Tobacco Co Tobacco article and method for producing a tobacco article.
EP2213181A1 (en) * 2009-01-28 2010-08-04 Philip Morris Products S.A. Smokeless dissolvable compressed tobacco product
US8926529B2 (en) * 2009-02-10 2015-01-06 Vesatek, Llc Method and apparatus for manipulating a surgical guidewire
CN102405074B (en) * 2009-02-23 2014-08-13 日本烟草产业株式会社 Non-heating type flavor inhaler
US8863755B2 (en) 2009-02-27 2014-10-21 Philip Morris Usa Inc. Controlled flavor release tobacco pouch products and methods of making
US9167847B2 (en) 2009-03-16 2015-10-27 Philip Morris Usa Inc. Production of coated tobacco particles suitable for usage in a smokeless tobacoo product
CN106619479A (en) * 2009-04-03 2017-05-10 X国际公司 Plant fiber product and preparation method thereof
US8434496B2 (en) 2009-06-02 2013-05-07 R. J. Reynolds Tobacco Company Thermal treatment process for tobacco materials
US8991403B2 (en) 2009-06-02 2015-03-31 R.J. Reynolds Tobacco Company Thermal treatment process for tobacco materials
US8944072B2 (en) 2009-06-02 2015-02-03 R.J. Reynolds Tobacco Company Thermal treatment process for tobacco materials
WO2010147024A1 (en) * 2009-06-16 2010-12-23 日本たばこ産業株式会社 Oral tobacco product
WO2010147026A1 (en) * 2009-06-17 2010-12-23 日本たばこ産業株式会社 Oral tobacco product
US9848634B2 (en) 2009-06-30 2017-12-26 Philip Morris Products S.A. Smokeless tobacco product
US8448647B2 (en) * 2009-08-28 2013-05-28 R. J. Reynolds Tobacco Company Feeder system for rod components of tobacco products
US9511914B2 (en) * 2009-09-01 2016-12-06 Philip Morris Usa Inc. Thermoformable multilayer films and blister packs produced therefrom
US9687023B2 (en) * 2009-10-09 2017-06-27 Philip Morris Usa Inc. Moist smokeless tobacco product for oral usage having on a portion of the outer surface at least one friction reducing strip that provides texture during use
US8747562B2 (en) 2009-10-09 2014-06-10 Philip Morris Usa Inc. Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release
US8539958B2 (en) * 2009-10-13 2013-09-24 Philip Morris Usa Inc. Oral moist smokeless tobacco products with net-structured gel coating and methods of making
US8640714B2 (en) * 2009-11-12 2014-02-04 Philip Morris Usa Inc. Oral chewable tobacco product and method of manufacture thereof
US11766068B1 (en) 2009-12-14 2023-09-26 Altria Client Services Llc Method of treating smokeless tobacco
US20110139164A1 (en) * 2009-12-15 2011-06-16 R. J. Reynolds Tobacco Company Tobacco Product And Method For Manufacture
US20110220130A1 (en) * 2009-12-15 2011-09-15 John-Paul Mua Tobacco Product And Method For Manufacture
WO2011087629A2 (en) * 2009-12-22 2011-07-21 Fmc Corporation Microcrystalline cellulose and calcium carbonate compositions useful as recompactible pharmaceutical excipients
US8096411B2 (en) 2010-01-12 2012-01-17 R. J. Reynolds Tabacco Company Dispensing container
EA033565B1 (en) 2010-01-15 2019-11-05 Univ North Carolina State Compositions and methods for minimizing nornicotine synthesis in tobacco plants
US8955523B2 (en) 2010-01-15 2015-02-17 R.J. Reynolds Tobacco Company Tobacco-derived components and materials
US20130014771A1 (en) 2011-01-13 2013-01-17 R. J. Reynolds Tobacco Company Tobacco-derived components and materials
US8397945B2 (en) 2010-02-23 2013-03-19 R.J. Reynolds Tobacco Company Dispensing container
US9743688B2 (en) 2010-03-26 2017-08-29 Philip Morris Usa Inc. Emulsion/colloid mediated flavor encapsulation and delivery with tobacco-derived lipids
US8268370B2 (en) * 2010-03-26 2012-09-18 Philip Morris Usa Inc. Solid oral sensorial products including stain inhibitor
US9862923B2 (en) 2010-03-26 2018-01-09 Philip Morris Usa Inc. Cultured tobacco cells as a matrix for consumable products
US10051884B2 (en) 2010-03-26 2018-08-21 Philip Morris Usa Inc. Controlled release mentholated tobacco beads
EP2553013B1 (en) 2010-04-01 2019-02-27 Ball Horticultural Company Cast pellets for planting seeds
US9039839B2 (en) * 2010-04-08 2015-05-26 R.J. Reynolds Tobacco Company Smokeless tobacco composition comprising tobacco-derived material and non-tobacco plant material
EP2558370B1 (en) 2010-04-12 2017-04-05 Altria Client Services LLC Pouch product with improved seal and method
RU2587570C2 (en) 2010-04-14 2016-06-20 Алтрия Клаинт Сервисиз Инк. Moulded smokeless tobacco product
US9402415B2 (en) 2010-04-21 2016-08-02 R. J. Reynolds Tobacco Company Tobacco seed-derived components and materials
GB201012090D0 (en) 2010-07-19 2010-09-01 British American Tobacco Co Cellulosic material
JP5946451B2 (en) 2010-08-05 2016-07-06 アルトリア クライアント サービシーズ リミテッド ライアビリティ カンパニー Composite smokeless tobacco products, systems, and methods
RU2580483C2 (en) 2010-08-05 2016-04-10 Олтриа Клайент Сервисиз Инк. Material with tobacco intertangled with structural fibres
CN101933653B (en) * 2010-08-09 2012-10-10 深圳市如烟生物科技有限公司 Officinal health-care solid electronic aerosolization liquid and preparation method thereof
US9155321B2 (en) 2010-08-11 2015-10-13 R.J. Reynolds Tobacco Company Meltable smokeless tobacco composition
US11116237B2 (en) 2010-08-11 2021-09-14 R.J. Reynolds Tobacco Company Meltable smokeless tobacco composition
US8905243B2 (en) 2010-08-11 2014-12-09 R.J. Reynolds Tobacco Company Apparatus for sorting objects, and associated method
CN103179869B (en) 2010-08-20 2016-05-18 日本烟草产业株式会社 Non-hot type cigarette essence aspirator
US10028520B2 (en) 2010-09-02 2018-07-24 R.J. Reynolds Tobacco Company Apparatus for manufacturing a smokeless tobacco product incorporating an object, and associated method
US9675102B2 (en) 2010-09-07 2017-06-13 R. J. Reynolds Tobacco Company Smokeless tobacco product comprising effervescent composition
RU2443155C1 (en) * 2010-10-11 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443157C1 (en) * 2010-10-11 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443156C1 (en) * 2010-10-11 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443160C1 (en) * 2010-10-11 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443144C1 (en) * 2010-10-11 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443163C1 (en) * 2010-10-20 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443165C1 (en) * 2010-10-20 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443166C1 (en) * 2010-10-20 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443169C1 (en) * 2010-10-20 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443171C1 (en) * 2010-10-20 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443164C1 (en) * 2010-10-20 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443162C1 (en) * 2010-10-20 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443175C1 (en) * 2010-10-27 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443172C1 (en) * 2010-10-27 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443177C1 (en) * 2010-10-27 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
RU2443173C1 (en) * 2010-10-27 2012-02-27 Олег Иванович Квасенков Method for production of non-smoking products of rustic tobacco
US8931493B2 (en) 2010-11-01 2015-01-13 R.J. Reynolds Tobacco Co. Smokeless tobacco products
US20120125354A1 (en) 2010-11-18 2012-05-24 R.J. Reynolds Tobacco Company Fire-Cured Tobacco Extract and Tobacco Products Made Therefrom
US9220295B2 (en) 2010-12-01 2015-12-29 R.J. Reynolds Tobacco Company Tobacco separation process for extracting tobacco-derived materials, and associated extraction systems
US20130263870A1 (en) * 2010-12-01 2013-10-10 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and moulding process for forming smokeless tobacco products
US9204667B2 (en) 2010-12-01 2015-12-08 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and injection molding process for forming smokeless tobacco products
US9775376B2 (en) 2010-12-01 2017-10-03 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and moulding process for forming smokeless tobacco products
AU2011338226B2 (en) 2010-12-10 2015-12-24 Altria Client Services Inc. Smokeless tobacco packaging system and method
US20120152265A1 (en) 2010-12-17 2012-06-21 R.J. Reynolds Tobacco Company Tobacco-Derived Syrup Composition
ES2842407T3 (en) * 2010-12-22 2021-07-14 Syqe Medical Ltd Drug delivery system
US9107453B2 (en) 2011-01-28 2015-08-18 R.J. Reynolds Tobacco Company Tobacco-derived casing composition
US8893725B2 (en) 2011-01-28 2014-11-25 R. J. Reynolds Tobacco Company Polymeric materials derived from tobacco
US9908670B2 (en) 2011-01-31 2018-03-06 American Snuff Company, Llc Container for smokeless tobacco products
JP2014515596A (en) 2011-02-28 2014-07-03 ノース カロライナ ステイト ユニヴァーシティ Tobacco inbred plants NCBEX1F, NCBEX1MS, and NCEX90
EP2682006A4 (en) * 2011-03-02 2014-11-05 Feellife Bioscience Internat Co Ltd Method for preparing gel-state water soluble flavoring essence used for cigarette
EP2682009B1 (en) 2011-03-02 2018-10-24 Japan Tobacco, Inc. Method for producing flavoring-containing sheet for smoking article
US9066538B2 (en) 2011-03-15 2015-06-30 R.J. Reynolds Tobacco Company Cured tobacco and method therefor
US9254001B2 (en) 2011-04-27 2016-02-09 R.J. Reynolds Tobacco Company Tobacco-derived components and materials
US9878464B1 (en) 2011-06-30 2018-01-30 Apinee, Inc. Preservation of cellulosic materials, compositions and methods thereof
TWI741707B (en) 2011-08-16 2021-10-01 美商尤爾實驗室有限公司 Device and methods for generating an inhalable aerosol
US20130118512A1 (en) 2011-11-16 2013-05-16 R.J. Reynolds Tobacco Company Smokeless tobacco products with starch component
US20130125907A1 (en) 2011-11-17 2013-05-23 Michael Francis Dube Method for Producing Triethyl Citrate from Tobacco
US20130125904A1 (en) 2011-11-18 2013-05-23 R.J. Reynolds Tobacco Company Smokeless tobacco product comprising pectin component
US10881132B2 (en) 2011-12-14 2021-01-05 R.J. Reynolds Tobacco Company Smokeless tobacco product comprising effervescent composition
CN103039688B (en) 2012-01-20 2016-01-06 奥驰亚客户服务公司 Oral product
CN103040090B (en) 2012-01-20 2016-03-30 奥驰亚客户服务公司 Remove the oral product of tobacco
CN102754908B (en) 2012-01-20 2015-06-10 奥驰亚客户服务公司 Oral tobacco product
US9854831B2 (en) 2012-01-20 2018-01-02 Altria Client Services Llc Oral product
AU2013204701B2 (en) * 2012-01-20 2016-12-01 Altria Client Services Llc Oral product
CN102754907B (en) * 2012-01-20 2015-06-24 奥驰亚客户服务公司 Oral product
US9282772B2 (en) 2012-01-31 2016-03-15 Altria Client Services Llc Electronic vaping device
US9420825B2 (en) 2012-02-13 2016-08-23 R.J. Reynolds Tobacco Company Whitened tobacco composition
US9289014B2 (en) 2012-02-22 2016-03-22 Altria Client Services Llc Electronic smoking article and improved heater element
WO2013142483A1 (en) 2012-03-19 2013-09-26 R. J. Reynolds Tobacco Company Method for treating an extracted tobacco pulp and tobacco products made therefrom
DK2649888T3 (en) 2012-04-10 2020-04-27 Swedish Match North Europe Ab Smokeless tobacco composition comprising non-tobacco fibers and a process for making them
USD784603S1 (en) 2012-04-11 2017-04-18 British American Tobacco (Investments) Limited Oral tobacco
USD784604S1 (en) 2012-04-11 2017-04-18 British American Tobacco (Investments) Limited Oral tobacco
USD729974S1 (en) 2012-04-11 2015-05-19 British American Tobacco (Investments) Limited Oral tobacco
GB2501092A (en) * 2012-04-11 2013-10-16 British American Tobacco Co Oral tobacco product
USD784602S1 (en) 2012-04-11 2017-04-18 British American Tobacco (Investments) Limited Oral tobacco
US9339058B2 (en) 2012-04-19 2016-05-17 R. J. Reynolds Tobacco Company Method for producing microcrystalline cellulose from tobacco and related tobacco product
US20130292279A1 (en) 2012-05-04 2013-11-07 R.J. Reynolds Tobacco Company Transparent moisture barrier coatings for containers
US11944114B2 (en) 2012-06-20 2024-04-02 Altria Client Services Llc Smokeless tobacco lipid granules
US20130340773A1 (en) 2012-06-22 2013-12-26 R.J. Reynolds Tobacco Company Composite tobacco-containing materials
US10517530B2 (en) 2012-08-28 2019-12-31 Juul Labs, Inc. Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances
US9521863B2 (en) 2012-09-19 2016-12-20 Altria Client Services Llc Methods of reducing tobacco-specific nitrosamines (TSNAs) and/or improving leaf quality in tobacco
US9386800B2 (en) 2012-09-21 2016-07-12 R.J. Reynolds Tobacco Company Fibrous composite tobacco-containing materials
US9591875B2 (en) 2012-09-21 2017-03-14 R. J. Reynolds Tobacco Company Fibrous composite tobacco-containing materials
US11412775B2 (en) 2012-10-09 2022-08-16 R.J. Reynolds Tobacco Company Tobacco-derived composition
WO2014078862A1 (en) 2012-11-19 2014-05-22 Altria Client Services Inc. Blending of agricultural products via hyperspectral imaging and analysis
GB201222986D0 (en) 2012-12-20 2013-01-30 British American Tobacco Co Smokeless oral tobacco product and preparation thereof
US9603335B2 (en) 2013-01-11 2017-03-28 North Carolina State University Tobacco inbred plants K326 SRC, CMS K326 SRC, K346 SRC, CMS K346 SRC, NC1562-1 SRC, NCTG-61 SRC, CMS NCTG-61 SRC and hybrid NC196 SRC
CN103005679B (en) * 2013-01-15 2015-04-08 李群星 Snuff with chrysanthemum aroma
CN103040096B (en) * 2013-01-15 2015-04-22 周午贤 Jasmine flower scent type snuff
CN103054166B (en) * 2013-01-15 2015-11-25 吕国栋 A kind of Chinese cinnamon type snuff
CN103005691B (en) * 2013-01-15 2015-04-29 王春霞 Amber odor type snuff
CN103005680B (en) * 2013-01-15 2015-03-25 陈孝忠 Geranium scent type snuff
CN103005682B (en) * 2013-01-15 2015-07-01 王文娟 Celery aroma type snuff
CN103005674B (en) * 2013-01-15 2015-04-08 李群星 Albizia flower odor type snuff
CN103005670B (en) * 2013-01-15 2015-04-29 陈汝德 Holy basil flavored snuff
CN103040095B (en) * 2013-01-15 2015-07-01 田凌燕 Osmanthus scent snuff
CN103005688B (en) * 2013-01-15 2015-04-08 李群星 Snuff with camellia fragrance
CN103005683B (en) * 2013-01-15 2015-04-22 陈雪芬 Rosin snuff
CN103054163B (en) * 2013-01-15 2015-04-08 李群星 Lily-flavored snuff
CN103005689B (en) * 2013-01-15 2015-04-08 李群星 Snuff with mint fragrance
CN103054164B (en) * 2013-01-15 2015-07-22 丁荣林 Jujube-flower-flavored snuff
CN103005684B (en) * 2013-01-15 2015-04-22 管延花 Rose flavored snuff
CN103054165B (en) * 2013-01-15 2015-07-22 晋清泉 Sandalwood type snuff
CN103040099B (en) * 2013-01-15 2015-04-22 李桂梅 Clove type snuff
CN103005681B (en) * 2013-01-15 2015-06-17 张晓慧 Snuff with calendula aroma
CN103005669B (en) * 2013-01-15 2015-04-08 李群星 Storax snuff
CN103027371B (en) * 2013-01-15 2015-04-22 王国琴 Myristica fragrans type snuff
CN103040098B (en) * 2013-01-15 2015-04-22 周午贤 Lavender odor type snuff
CN103040103B (en) * 2013-01-15 2015-04-08 李群星 Fennel type snuff
CN103054167B (en) * 2013-01-15 2015-07-22 李彩香 Rosemary scented snuff
CN103054168B (en) * 2013-01-15 2015-03-11 黑龙江中医药大学 Lotus incense type snuff
EP2964016A1 (en) 2013-03-05 2016-01-13 North Carolina State University Tobacco inbred and hybrid plants and uses thereof
US9289011B2 (en) 2013-03-07 2016-03-22 R.J. Reynolds Tobacco Company Method for producing lutein from tobacco
US9402414B2 (en) 2013-03-14 2016-08-02 Altria Client Services Llc Smokeless tobacco article
US9301544B2 (en) 2013-03-14 2016-04-05 R.J. Reynolds Tobacco Company Protein-enriched tobacco-derived composition
US9661876B2 (en) 2013-03-14 2017-05-30 R.J. Reynolds Tobacco Company Sugar-enriched extract derived from tobacco
CA2905059C (en) 2013-03-14 2021-11-02 Altria Client Services Llc Product portion enrobing machines and methods
US10799548B2 (en) 2013-03-15 2020-10-13 Altria Client Services Llc Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
EP4154736A1 (en) 2013-03-15 2023-03-29 Altria Client Services LLC Methods and machines for pouching smokeless tobacco and tobacco substitute products
US10226064B2 (en) 2013-03-15 2019-03-12 Altria Client Services Llc Nitrite-degrading and TSNA-degrading bacteria and methods of making and using
CN103214991B (en) * 2013-04-02 2015-01-28 大亚科技股份有限公司 Polypropylene tip filter stick adhesive for modifying cigarettes and application thereof
IL297399B2 (en) 2013-05-06 2024-02-01 Juul Labs Inc Nicotine salt formulations for aerosol devices and methods thereof
EP2957183A4 (en) * 2013-05-13 2016-11-16 Japan Tobacco Inc Tobacco material, tobacco product to which tobacco material is added, and method for producing tobacco material
US9814864B2 (en) * 2013-05-17 2017-11-14 Covidien Lp Torque apparatus for use with a guidewire
CN105473012B (en) 2013-06-14 2020-06-19 尤尔实验室有限公司 Multiple heating elements with individual vaporizable materials in electronic vaporization devices
US20150034109A1 (en) 2013-08-02 2015-02-05 R.J. Reynolds Tobacco Company Process for Producing Lignin from Tobacco
US9629391B2 (en) 2013-08-08 2017-04-25 R.J. Reynolds Tobacco Company Tobacco-derived pyrolysis oil
US11503853B2 (en) 2013-09-09 2022-11-22 R.J. Reynolds Tobacco Company Smokeless tobacco composition incorporating a botanical material
US11779045B2 (en) * 2013-10-03 2023-10-10 Altria Client Services Llc Dissolvable-chewable exhausted-tobacco tablet
US10244786B2 (en) 2013-10-03 2019-04-02 Altria Client Services Llc Tobacco lozenge
US20150096574A1 (en) * 2013-10-03 2015-04-09 Altria Client Services Inc. Dissolvable-chewable tobacco tablet
WO2015051306A1 (en) * 2013-10-03 2015-04-09 Altria Client Services Inc. Dissolvable chewable tablet
US11771127B2 (en) * 2013-10-03 2023-10-03 Altria Client Services Llc Chewable dissolvable nicotine tablet
US10105320B2 (en) 2013-10-03 2018-10-23 Altria Client Services Soluble fiber lozenge
US9999243B2 (en) 2013-10-03 2018-06-19 Altria Client Services Llc Exhausted tobacco lozenge
DK3054794T3 (en) 2013-10-09 2017-08-28 Swedish Match North Europe Ab AN ORAL SMOKE-TOBACCO COMPOSITION INCLUDING RELEASED, DELIGNIFIED TOBACCO FIBER AND A PROCEDURE FOR ITS PREPARATION
US10357054B2 (en) 2013-10-16 2019-07-23 R.J. Reynolds Tobacco Company Smokeless tobacco pastille
CN103549648B (en) * 2013-11-11 2016-08-17 云南烟草科学研究院 A kind of Novel pressure flap-type smokeless tobacco articles and preparation method thereof
CN103549646B (en) * 2013-11-11 2016-03-02 云南烟草科学研究院 Containing the oral disintegrating tablet type smokeless tobacco articles and preparation method thereof of tobacco ultra-micro powder
US9717272B2 (en) 2013-11-20 2017-08-01 R. J. Reynolds Tobacco Company Container for smokeless tobacco product
CN113142679A (en) 2013-12-05 2021-07-23 尤尔实验室有限公司 Nicotine liquid formulations for aerosol devices and methods thereof
WO2015085299A1 (en) 2013-12-06 2015-06-11 Altria Client Services Inc. Tobacco plants having altered amounts of one or more alkaloids in leaf and methods of using such plants
US20160366947A1 (en) 2013-12-23 2016-12-22 James Monsees Vaporizer apparatus
US9549573B2 (en) 2013-12-23 2017-01-24 Pax Labs, Inc. Vaporization device systems and methods
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
GB2560651B8 (en) 2013-12-23 2018-12-19 Juul Labs Uk Holdco Ltd Vaporization device systems and methods
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US9265284B2 (en) 2014-01-17 2016-02-23 R.J. Reynolds Tobacco Company Process for producing flavorants and related materials
US9375033B2 (en) * 2014-02-14 2016-06-28 R.J. Reynolds Tobacco Company Tobacco-containing gel composition
WO2015134423A1 (en) 2014-03-03 2015-09-11 North Carolina State University Tobacco inbred and hybrid plants and tobacco products made thereof
EP3113603A1 (en) 2014-03-03 2017-01-11 North Carolina State University Tobacco inbred and hybrid plants and tobacco products made thereof
JP2017508462A (en) 2014-03-03 2017-03-30 ノース カロライナ ステイト ユニヴァーシティ Tobacco inbred and hybrid plants and tobacco products made therefrom
EP3116330B1 (en) 2014-03-14 2021-08-11 Altria Client Services LLC Polymer encased smokeless tobacco products
EP3597052B1 (en) 2014-03-14 2023-12-27 Altria Client Services LLC Product portion enrobing process and apparatus
US10906726B2 (en) 2014-04-01 2021-02-02 R. J. Reynolds Tobacco Company Dispensing system for a tobacco-related product, and associated method
US20150322451A1 (en) 2014-04-08 2015-11-12 Altria Client Services Inc. Tobacco having altered leaf properties and methods of making and using
WO2015175979A1 (en) 2014-05-16 2015-11-19 Pax Labs, Inc. Systems and methods for aerosolizing a smokeable material
US20170189333A1 (en) 2014-05-22 2017-07-06 University Of Copenhagen Aqueous gel composition and its use
WO2016001924A2 (en) 2014-06-30 2016-01-07 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
AU2015283593B2 (en) 2014-06-30 2019-08-22 Syqe Medical Ltd. Drug dose cartridge for an inhaler device
AU2015283590B2 (en) 2014-06-30 2020-04-16 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
DK3160558T3 (en) 2014-06-30 2020-04-27 Syqe Medical Ltd FLOW CONTROL INHALING DEVICE
US11298477B2 (en) 2014-06-30 2022-04-12 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
ES2904293T3 (en) 2014-06-30 2022-04-04 Syqe Medical Ltd Device for vaporization and inhalation of isolated substances
US10113174B2 (en) 2014-07-02 2018-10-30 Altria Client Services Llc Tobacco having altered leaf properties and methods of making and using
US10626409B2 (en) 2014-07-08 2020-04-21 Altria Client Services Llc Genetic locus imparting a low anatabine trait in tobacco and methods of using
CN104059560A (en) * 2014-07-08 2014-09-24 山东津美生物科技有限公司 Cigarette holder adhesive and preparation method thereof
US10258717B2 (en) * 2014-08-05 2019-04-16 The University Of Memphis Compositions and methods for enhancing healing and regeneration of bone and soft tissue
US20160044955A1 (en) 2014-08-13 2016-02-18 R.J. Reynolds Tobacco Company Smokeless tobacco products
EP3204501B1 (en) 2014-10-06 2019-01-09 Altria Client Services LLC Genetic control of axillary bud growth in tobacco plants
US9968130B2 (en) 2014-10-16 2018-05-15 R.J. Reynolds Tobacco Company Package for a tobacco-containing material with a valve assembly and related packaging method
RU2709926C2 (en) 2014-12-05 2019-12-23 Джуул Лэбз, Инк. Calibrated dose control
US20160157515A1 (en) 2014-12-05 2016-06-09 R.J. Reynolds Tobacco Company Smokeless tobacco pouch
WO2016110689A1 (en) 2015-01-07 2016-07-14 British American Tobacco (Investments) Limited Material for inclusion in a smoking article
US11317649B2 (en) 2015-01-07 2022-05-03 British American Tobacco (Investments) Limited Material for inclusion in a smoking article
WO2016123425A1 (en) 2015-01-29 2016-08-04 Altria Client Services Llc Endolysin from bacteriophage against geobacillus and methods of using
US9781929B2 (en) 2015-01-29 2017-10-10 Altria Client Services Llc Bacteriophage and methods of using
JP6001108B2 (en) * 2015-02-02 2016-10-05 エクス−インターナショナル・エピエス Plant fiber product and method for producing the same
BR112017018316A2 (en) 2015-02-27 2018-04-17 Ebbu Llc compositions comprising combinations of purified cannabinoids with at least one flavonoid, terpene or mineral
WO2017100369A1 (en) * 2015-12-07 2017-06-15 Ebbu, LLC Printable cannabinoid and terpene compositions
DE102015205768A1 (en) * 2015-03-31 2016-10-06 Hauni Maschinenbau Gmbh A method of making a first subunit of a HNB smoking article having a rod body and a cavity disposed thereon
US10881133B2 (en) 2015-04-16 2021-01-05 R.J. Reynolds Tobacco Company Tobacco-derived cellulosic sugar
CN104805726A (en) * 2015-05-06 2015-07-29 嘉兴景程生物科技有限公司 Cigarette paper for cigarettes and preparation method of cigarette paper
US11147309B2 (en) 2015-06-10 2021-10-19 R.J. Reynolds Tobacco Company Container for smokeless tobacco products comprising a pulp material and related packaged product assembly and method
WO2017027837A1 (en) 2015-08-12 2017-02-16 Vesatek, Llc System and method for manipulating an elongate medical device
US20170059554A1 (en) 2015-09-02 2017-03-02 R. J. Reynolds Tobacco Company Method for monitoring use of a tobacco product
US20170055565A1 (en) 2015-09-02 2017-03-02 R. J. Reynolds Tobacco Company Systems and Apparatus for Reducing Tobacco-Specific Nitrosamines in Dark-Fire Cured Tobacco Through Electronic Control of Curing Conditions
US10561440B2 (en) 2015-09-03 2020-02-18 Vesatek, Llc Systems and methods for manipulating medical devices
US10869497B2 (en) 2015-09-08 2020-12-22 R.J. Reynolds Tobacco Company High-pressure cold pasteurization of tobacco material
US11641874B2 (en) 2015-09-09 2023-05-09 R.J. Reynolds Tobacco Company Flavor delivery article
US11258366B2 (en) 2015-11-20 2022-02-22 Galvion Soldier Power, Llc Power manager with reconfigurable power converting circuits
AU2016355125A1 (en) 2015-11-20 2018-07-05 David Long Power manager with reconfigurable power converting circuits
US11612183B2 (en) 2015-12-10 2023-03-28 R.J. Reynolds Tobacco Company Protein-enriched tobacco composition
US20170172200A1 (en) 2015-12-16 2017-06-22 R.J. Reynolds Tobacco Company Flavor additive accessory
US10226263B2 (en) 2015-12-23 2019-03-12 Incuvate, Llc Aspiration monitoring system and method
WO2017115234A1 (en) 2015-12-28 2017-07-06 R. J. Reynolds Tobacco Company Package for a tobacco-containing material and related packaging method
US11806331B2 (en) 2016-01-06 2023-11-07 Syqe Medical Ltd. Low dose therapeutic treatment
US10499684B2 (en) 2016-01-28 2019-12-10 R.J. Reynolds Tobacco Company Tobacco-derived flavorants
MX2018009703A (en) 2016-02-11 2019-07-08 Juul Labs Inc Securely attaching cartridges for vaporizer devices.
UA125687C2 (en) 2016-02-11 2022-05-18 Джуул Лебз, Інк. Fillable vaporizer cartridge and method of filling
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
EP3442326A1 (en) 2016-04-13 2019-02-20 Altria Client Services LLC Tobacco plants exhibiting altered photosynthesis and methods of making and using the same
US10329068B2 (en) 2016-05-23 2019-06-25 R.J. Reynolds Tobacco Company Flavoring mechanism for a tobacco related material
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
US10375984B2 (en) 2016-07-18 2019-08-13 R.J. Reynolds Tobacco Company Nonwoven composite smokeless tobacco product
US11425929B2 (en) 2016-07-25 2022-08-30 Aubrey Ray Thoede, Jr. Smoking apparatus and method of use
EP3503875A4 (en) 2016-08-29 2020-06-24 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
US11660403B2 (en) 2016-09-22 2023-05-30 Juul Labs, Inc. Leak-resistant vaporizer device
EP3523428B1 (en) 2016-10-07 2024-01-10 Altria Client Services LLC Tobacco plants having increased nitrogen efficiency and methods of using such plants
US20180199617A1 (en) * 2017-01-18 2018-07-19 Bianca Iodice Tobacco Free Hookah Smoking Gel
US10342259B2 (en) 2017-03-21 2019-07-09 Altria Client Services Llc Flavor delivery system
US11091446B2 (en) 2017-03-24 2021-08-17 R.J. Reynolds Tobacco Company Methods of selectively forming substituted pyrazines
US10470487B2 (en) 2017-04-06 2019-11-12 R.J. Reynolds Tobacco Company Smoke treatment
WO2019026997A1 (en) * 2017-08-03 2019-02-07 森永乳業株式会社 Edible film
US11457659B2 (en) 2017-08-04 2022-10-04 Altria Client Services Llc Stabilization methods for tobacco and tobacco products
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
GB201801257D0 (en) 2018-01-25 2018-03-14 British American Tobacco Investments Ltd Apparatus for heating aerosol-generating material
US10548347B2 (en) 2018-02-23 2020-02-04 American Snuff Company, Llc Container for smokeless tobacco products
KR101998288B1 (en) * 2018-03-09 2019-07-09 (주)씨엘팜 Composition for smokeless tobacco and orally dissolving film-type smokeless tobacco comprising the same
US20190307082A1 (en) 2018-04-05 2019-10-10 R.J. Reynolds Tobacco Company Oriental tobacco production methods
DK3774570T3 (en) 2018-04-13 2022-05-23 Reynolds Tobacco Co R LID FOR A CONTAINER FOR SMOKE-FREE TOBACCO PRODUCTS AND METHOD FOR MANUFACTURE OF SUCH A LID
US11678905B2 (en) 2018-07-19 2023-06-20 Walk Vascular, Llc Systems and methods for removal of blood and thrombotic material
PL3826478T3 (en) * 2018-07-26 2024-01-15 Philip Morris Products S.A. Article for forming an aerosol
GB201812509D0 (en) * 2018-07-31 2018-09-12 Nicoventures Holdings Ltd Aerosol generation
CN109315820A (en) * 2018-08-10 2019-02-12 杨福荣 Cigarette ingredient, preparation method and the cigarette using it
CN109259298B (en) * 2018-11-06 2021-12-14 彭荣淮 Method for producing substitute tobacco sheet from corn bract powder
WO2020097341A1 (en) 2018-11-08 2020-05-14 Juul Labs, Inc. Cartridges for vaporizer devices
US20200196658A1 (en) 2018-12-20 2020-06-25 R.J. Reynolds Tobacco Company Method for whitening tobacco
US11877590B2 (en) 2019-03-27 2024-01-23 Fiedler & Lundgren Ab Smokeless tobacco composition
CN117837794A (en) * 2019-04-08 2024-04-09 菲利普莫里斯生产公司 Aerosol-generating film
US11213062B2 (en) 2019-05-09 2022-01-04 American Snuff Company Stabilizer for moist snuff
CA3150662A1 (en) 2019-09-11 2021-03-18 Michael Andrew Zawadzki Alternative methods for whitening tobacco
US12063953B2 (en) 2019-09-11 2024-08-20 Nicoventures Trading Limited Method for whitening tobacco
US20210068447A1 (en) 2019-09-11 2021-03-11 R. J. Reynolds Tobacco Company Pouched products with enhanced flavor stability
US20220071984A1 (en) * 2019-09-11 2022-03-10 Nicoventures Trading Limited Oral product with nicotine and ion pairing agent
US20210068446A1 (en) * 2019-09-11 2021-03-11 R. J. Reynolds Tobacco Company Oral product with cellulosic flavor stabilizer
US11369131B2 (en) 2019-09-13 2022-06-28 Nicoventures Trading Limited Method for whitening tobacco
US11903406B2 (en) 2019-09-18 2024-02-20 American Snuff Company, Llc Method for fermenting tobacco
MX2022005285A (en) 2019-10-31 2022-05-24 Nicoventures Trading Ltd Oral product and method of manufacture.
GB201917475D0 (en) * 2019-11-29 2020-01-15 Nicoventures Trading Ltd Aerosol generation
MX2022006980A (en) 2019-12-09 2022-08-25 Nicoventures Trading Ltd Pouched products with heat sealable binder.
WO2021116916A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral product with multiple flavors having different release profiles
CA3159459A1 (en) 2019-12-09 2021-06-17 Savannah JOHNSON Layered fleece for pouched product
CA3160750A1 (en) 2019-12-09 2021-06-17 Anthony Richard Gerardi Oral product comprising a cannabinoid
US20210169783A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral products with controlled release
US20210169785A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral compositions with reduced water activity
WO2021116895A2 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Stimulus-responsive pouch
WO2021116856A2 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral products
WO2021116854A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral products with active ingredient combinations
US11872231B2 (en) 2019-12-09 2024-01-16 Nicoventures Trading Limited Moist oral product comprising an active ingredient
US20210169132A1 (en) * 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral composition including gels
US11889856B2 (en) 2019-12-09 2024-02-06 Nicoventures Trading Limited Oral foam composition
US11672862B2 (en) 2019-12-09 2023-06-13 Nicoventures Trading Limited Oral products with reduced irritation
CA3159813A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral product with dissolvable component
US20210169138A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Fibrous fleece material
US20210169126A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral composition with salt inclusion
US20210169788A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral product and method of manufacture
WO2021116865A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Agents for oral composition
US20210169121A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Liquid oral composition
US20210169137A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Pouched products
US11617744B2 (en) 2019-12-09 2023-04-04 Nico Ventures Trading Limited Moist oral compositions
WO2021116881A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral product in a pourous pouch comprising a fleece material
WO2021116842A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral products with controlled release
WO2021116919A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Fleece for oral product with releasable component
US20210169786A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral composition with beet material
EP4072338A1 (en) * 2019-12-09 2022-10-19 Nicoventures Trading Limited Agents for oral composition
US11793230B2 (en) 2019-12-09 2023-10-24 Nicoventures Trading Limited Oral products with improved binding of active ingredients
AU2020399278A1 (en) 2019-12-09 2022-06-30 Nicoventures Trading Limited Nanoemulsion for oral use
US11969502B2 (en) 2019-12-09 2024-04-30 Nicoventures Trading Limited Oral products
US11826462B2 (en) 2019-12-09 2023-11-28 Nicoventures Trading Limited Oral product with sustained flavor release
US20210170031A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral composition with nanocrystalline cellulose
US20210169129A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Lipid-containing oral composition
US20210169123A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Pouched products with enhanced flavor stability
US11883527B2 (en) 2019-12-09 2024-01-30 Nicoventures Trading Limited Oral composition and method of manufacture
US20210169890A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral composition with polymeric component
WO2021116855A1 (en) 2019-12-09 2021-06-17 Nicoventures Trading Limited Oral compositions and methods of manufacture
US20210169784A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Buffered oral compositions
US20210169868A1 (en) 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral compositions with reduced water content
EP3837995A1 (en) * 2019-12-18 2021-06-23 Nerudia Limited A smokeless article
US11712059B2 (en) 2020-02-24 2023-08-01 Nicoventures Trading Limited Beaded tobacco material and related method of manufacture
US12016369B2 (en) 2020-04-14 2024-06-25 Nicoventures Trading Limited Regenerated cellulose substrate for aerosol delivery device
WO2021250516A1 (en) 2020-06-08 2021-12-16 Nicoventures Trading Limited Effervescent oral composition comprising an active ingredient
US20220104543A1 (en) 2020-09-04 2022-04-07 Nicoventures Trading Limited Child-resistant container for tobacco-containing products
US11937626B2 (en) 2020-09-04 2024-03-26 Nicoventures Trading Limited Method for whitening tobacco
CA3195031A1 (en) * 2020-10-07 2022-04-14 Celine Gambs An aerosol-forming substrate
US20240008522A1 (en) 2020-11-18 2024-01-11 Nicoventures Trading Limited Oral products
US11839602B2 (en) 2020-11-25 2023-12-12 Nicoventures Trading Limited Oral cannabinoid product with lipid component
WO2022115309A1 (en) * 2020-11-30 2022-06-02 Juul Labs, Inc. Polysaccharide-based tobacco gel compositions
US20220183389A1 (en) 2020-12-11 2022-06-16 Rai Strategic Holdings, Inc. Sleeve for smoking article
EP4284972A1 (en) 2021-01-28 2023-12-06 Nicoventures Trading Limited Method for sealing pouches
EP4304568A1 (en) 2021-03-09 2024-01-17 Nicoventures Trading Limited Oral products and methods of manufacture
US20220313614A1 (en) 2021-04-06 2022-10-06 Altria Client Services Llc Encapsulated nicotine granules and methods of preparation thereof
US20220313678A1 (en) 2021-04-06 2022-10-06 Altria Client Services Llc Spray dried nicotine for inclusion in oral products
US20220313679A1 (en) 2021-04-06 2022-10-06 Altria Client Services Llc Controlled-release nicotine chewing gum
US20220312825A1 (en) 2021-04-06 2022-10-06 Altria Client Services Llc Oral pouch product
US20220312822A1 (en) 2021-04-06 2022-10-06 Altria Client Services Llc Encapsulated sweetener granules and methods of preparation thereof
US20220312826A1 (en) 2021-04-06 2022-10-06 Altria Client Services Llc Liquid mixtures of triglyceride and liquid nicotine
US20220354785A1 (en) 2021-04-22 2022-11-10 Nicoventures Trading Limited Oral lozenge products
CA3216265A1 (en) 2021-04-22 2022-10-27 Michael Andrew Zawadzki Orally dissolving films
MX2023012535A (en) 2021-04-22 2024-01-24 Nicoventures Trading Ltd Effervescent oral composition.
EP4326097A1 (en) 2021-04-22 2024-02-28 Nicoventures Trading Limited Oral compositions and methods of manufacture
US20220354155A1 (en) 2021-04-30 2022-11-10 Nicoventures Trading Limited Multi-compartment oral pouched product
WO2022248378A1 (en) * 2021-05-27 2022-12-01 Philip Morris Products S.A. Method for producing an aerosol-forming substrate and aerosol-forming substrate
EP4355121A1 (en) 2021-06-16 2024-04-24 Nicoventures Trading Limited Pouched product comprising dissolvable composition
KR20240004756A (en) 2021-06-17 2024-01-11 니뽄 다바코 산교 가부시키가이샤 Flavor molded body and method for producing the same, method for producing tobacco materials, and method for producing tobacco products
MX2023015531A (en) 2021-06-21 2024-03-05 Nicoventures Trading Ltd Oral product tablet and method of manufacture.
MX2023015529A (en) 2021-06-25 2024-03-05 Nicoventures Trading Ltd Oral products and method of manufacture.
WO2023002198A1 (en) 2021-07-22 2023-01-26 Nicoventures Trading Limited Compositions comprising a constituent, derivative or extract of cannabis
IL310125A (en) 2021-07-22 2024-03-01 Nicoventures Trading Ltd Compositions comprising a constituent, derivative or extract of cannabis
EP4373299A1 (en) 2021-07-22 2024-05-29 Nicoventures Trading Limited Constituent, derivative or extract of cannabis in amorphous form
EP4373296A1 (en) 2021-07-22 2024-05-29 Nicoventures Trading Limited Compositions comprising constituents, derivatives or extracts of cannabis
JP2024526749A (en) 2021-07-22 2024-07-19 ニコベンチャーズ トレーディング リミテッド Methods for preparing compositions containing cannabis components, derivatives or extracts
EP4373300A1 (en) 2021-07-22 2024-05-29 Nicoventures Trading Limited Composition comprising a constituent, derivative or extract of cannabis
JP2024526747A (en) 2021-07-22 2024-07-19 ニコベンチャーズ トレーディング リミテッド Cannabis components, derivatives or extracts in an aqueous matrix
AU2022315022A1 (en) 2021-07-22 2024-01-18 Nicoventures Trading Limited Compositions comprising constituents, derivatives or extracts of cannabis
KR20230048194A (en) * 2021-10-01 2023-04-11 주식회사 케이티앤지 Flavoring sheet with improved surface roughness, smoking article including the same and method for manufacturing the same
CA3238147A1 (en) 2021-11-15 2023-05-19 Christopher Keller Products with enhanced sensory characteristics
US20230148652A1 (en) 2021-11-15 2023-05-18 Nicoventures Trading Limited Oral products with nicotine-polymer complex
WO2023174523A1 (en) * 2022-03-15 2023-09-21 Habit Factory In Sweden Ab Nicotine composition
US20230309603A1 (en) 2022-03-31 2023-10-05 R.J. Reynolds Tobacco Company Agglomerated botanical material for oral products
WO2023194959A1 (en) 2022-04-06 2023-10-12 Nicoventures Trading Limited Pouched products with heat sealable binder
WO2024069373A1 (en) 2022-09-26 2024-04-04 Nicoventures Trading Limited Child-resistant container for tobacco-containing products
WO2024069542A1 (en) 2022-09-30 2024-04-04 R. J. Reynolds Tobacco Company Method for forming reconstituted tobacco
WO2024069544A1 (en) 2022-09-30 2024-04-04 Nicoventures Trading Limited Reconstituted tobacco substrate for aerosol delivery device
US20240109697A1 (en) 2022-10-03 2024-04-04 Nicoventures Trading Limited Sealing member for packaging
WO2024074988A1 (en) 2022-10-04 2024-04-11 R. J. Reynolds Tobacco Company Stackable arrangement of product containers and related method of stacking
WO2024079722A1 (en) 2022-10-14 2024-04-18 Nicoventures Trading Limited Capsule-containing pouched products
WO2024089588A1 (en) 2022-10-24 2024-05-02 Nicoventures Trading Limited Shaped pouched products
WO2024095164A1 (en) 2022-11-01 2024-05-10 Nicoventures Trading Limited Products with spherical filler
WO2024171117A1 (en) 2023-02-15 2024-08-22 Nicoventures Trading Limited Oral products with high-density load
WO2024201343A1 (en) 2023-03-30 2024-10-03 Nicoventures Trading Limited Oral compositions and methods of manufacture
WO2024201346A1 (en) 2023-03-31 2024-10-03 Nicoventures Trading Limited Functionalized fleece material production
WO2024201301A1 (en) 2023-03-31 2024-10-03 Nicoventures Trading Limited Starchless molding process for oral products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935604A (en) * 1993-05-20 1999-08-10 Danbiosyst Uk Limited Nasal drug delivery composition containing nicotine

Family Cites Families (388)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734510A (en) * 1956-02-14 Preparing
US904521A (en) * 1908-04-20 1908-11-24 Carleton Ellis Masticable tobacco substitute.
US1376586A (en) 1918-04-06 1921-05-03 Schwartz Francis Tobacco-tablet
US2770241A (en) * 1954-05-10 1956-11-13 American Collo Corp Tobacco smoke filter and method
US2897103A (en) * 1957-08-05 1959-07-28 Gen Cigar Co Tobacco products and process therefor
US3067068A (en) 1959-03-09 1962-12-04 E R B Tobacco Products Co Inc Tobacco-like composition
US3098492A (en) 1960-11-25 1963-07-23 Nat Starch Chem Corp Method of making tobacco product
US3151996A (en) 1961-01-26 1964-10-06 Hercules Powder Co Ltd Adhesive comoposition and process of making corrugated paperboard therewith
US3166078A (en) * 1961-04-05 1965-01-19 Lorillard Co P Chewing tobacco product
US3046993A (en) 1961-05-15 1962-07-31 Lenardo Cigar Corp Cigar using homogenized leaf
US3120233A (en) 1961-09-25 1964-02-04 Fmc Corp Method for manufacturing recon-stituted tobacco products
US3240214A (en) * 1963-12-27 1966-03-15 Philip Morris Inc Method of making a composite tobacco sheet
US3455714A (en) 1964-09-01 1969-07-15 Hercules Inc Cellulose derivatives of improved dispersibility and process
US3292635A (en) * 1964-10-22 1966-12-20 Maxwell H Kolodny Integral cigarette-cigarette holder
US3313305A (en) 1965-08-11 1967-04-11 Beatrice Foods Co Cigarette filter
US3435027A (en) * 1965-12-13 1969-03-25 Hercules Inc Cellulose ether-esters and process
US3483148A (en) 1967-09-28 1969-12-09 Hercules Inc Protective coating composition of binder latex in water-glycol vehicle
US3470883A (en) 1968-08-29 1969-10-07 Nat Patent Dev Corp Tobacco smoke filters
US3625225A (en) 1969-07-24 1971-12-07 Amf Inc Reconstituted tobacco
US3951155A (en) * 1970-07-11 1976-04-20 Carreras Rothmans Limited Smoking materials
US3942537A (en) * 1971-03-10 1976-03-09 International Flavors & Fragrances Inc. Novel flavoring compositions and processes
US3857972A (en) 1971-03-10 1974-12-31 Int Flavors & Fragrances Inc Flavoring with an oxocyclic pyrimidine
US4014349A (en) * 1972-08-31 1977-03-29 Imperial Chemical Industries Limited Smoking material
US3891582A (en) 1973-04-26 1975-06-24 Hercules Inc Joint cement compositions utilizing water-insoluble carboxymethylated cellulose derivatives as asbestos substitutes
US3835074A (en) 1973-04-26 1974-09-10 Hercules Inc Joint cement compositions
GB1435304A (en) * 1973-11-13 1976-05-12 Carreras Rothmans Ltd Alginate fibres
US4014541A (en) * 1974-04-26 1977-03-29 Hercules Incorporated Golf tee
US3968804A (en) 1974-05-20 1976-07-13 Amf Incorporated Extruded tobacco sheet
JPS554625Y2 (en) 1974-05-28 1980-02-02
US4136162A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US4136145A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US4065319A (en) 1975-11-18 1977-12-27 Hercules Incorporated Tile cements
US4142535A (en) * 1976-05-04 1979-03-06 Imperial Group Limited Smoking product
GB1548022A (en) * 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
CA1097233A (en) 1977-07-20 1981-03-10 George K. E. Gregory Packages
US4325391A (en) * 1979-01-05 1982-04-20 Amf Incorporated Instantaneous slurry preparation on a continuous basis
JPS5758615A (en) 1980-09-26 1982-04-08 Nippon Soda Co Ltd Film agnent and its preparation
US4683256A (en) 1980-11-06 1987-07-28 Colorcon, Inc. Dry edible film coating composition, method and coating form
US4317837A (en) 1980-11-25 1982-03-02 Life Savers, Inc. Tobacco-flavored chewing gum
US4515769A (en) 1981-12-01 1985-05-07 Borden, Inc. Encapsulated flavorant material, method for its preparation, and food and other compositions incorporating same
CH658594A5 (en) 1982-02-22 1986-11-28 Bruss Ni Sanitarno Gigieniches MEDICINAL PRODUCT WITH ANTINICOTINE EFFECT AND METHOD FOR THE PRODUCTION THEREOF.
US4874000A (en) 1982-12-30 1989-10-17 Philip Morris Incorporated Method and apparatus for drying and cooling extruded tobacco-containing material
US4632131A (en) 1984-07-03 1986-12-30 Philip Morris Incorporated Foamed, extruded, coherent multistrand smoking articles
US4510950A (en) * 1982-12-30 1985-04-16 Philip Morris Incorporated Foamed, extruded, tobacco-containing smoking article and method of making same
EP0115955B1 (en) 1983-01-31 1988-10-19 Hercules Incorporated Tile mortars
US4501617A (en) * 1983-01-31 1985-02-26 Hercules Incorporated Tile mortars
EP0118637A2 (en) 1983-02-14 1984-09-19 Hercules Incorporated Tape joint cement composition
DE3475795D1 (en) 1983-02-14 1989-02-02 Hercules Inc Tape joint cement composition
US4513756A (en) * 1983-04-28 1985-04-30 The Pinkerton Tobacco Company Process of making tobacco pellets
GB8317576D0 (en) * 1983-06-29 1983-08-03 Shaw A S W Consumer tobacco products
US4545392A (en) 1983-07-25 1985-10-08 R. J. Reynolds Tobacco Co. Tobacco product
CA1263790A (en) 1983-08-01 1989-12-05 Armand Joseph Desmarais Denture adhesive composition
US5024701A (en) 1983-08-01 1991-06-18 Hercules Incorporated Denture adhesive composition
US4596259A (en) 1983-08-22 1986-06-24 R. J. Reynolds Tobacco Company Smoking material and method for its preparation
US5092352A (en) * 1983-12-14 1992-03-03 American Brands, Inc. Chewing tobacco product
US4611608A (en) 1984-01-13 1986-09-16 Naarden International N.V. Process for utilizing tobacco dust
US4558079A (en) 1984-01-24 1985-12-10 Hercules Incorporated Tape joint cement composition
US5288498A (en) * 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
EP0166315B1 (en) 1984-06-19 1989-08-23 BASF Aktiengesellschaft Gastro-resistant cylindrical pancreatine-microtablets
US4596257A (en) 1984-06-29 1986-06-24 Philip Morris Incorporated Method and apparatus for tipping smoking articles
US4643894A (en) * 1984-07-24 1987-02-17 Colorcon, Inc. Maltodextrin coating
US4828841A (en) 1984-07-24 1989-05-09 Colorcon, Inc. Maltodextrin coating
US4624269A (en) * 1984-09-17 1986-11-25 The Pinkerton Tobacco Company Chewable tobacco based product
SE8405479D0 (en) * 1984-11-01 1984-11-01 Nilsson Sven Erik WANT TO ADMINISTER VOCABULARY, PHYSIOLOGY, ACTIVE SUBJECTS AND DEVICE FOR THIS
US4606357A (en) * 1984-11-19 1986-08-19 Dusek Russell L Tobacco composition
JPS61111677U (en) 1984-12-25 1986-07-15
GB8500281D0 (en) 1985-01-05 1985-02-13 Glamorgan Electronics Ltd Vehicle tyre monitoring system
JPS61163005U (en) 1985-03-29 1986-10-09
US5288497A (en) 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US5783207A (en) 1985-05-01 1998-07-21 University Of Utah Research Foundation Selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine
US5785989A (en) 1985-05-01 1998-07-28 University Utah Research Foundation Compositions and methods of manufacturing of oral dissolvable medicaments
US4800903A (en) * 1985-05-24 1989-01-31 Ray Jon P Nicotine dispenser with polymeric reservoir of nicotine
US4661359A (en) * 1985-06-03 1987-04-28 General Mills, Inc. Compositions and methods for preparing an edible film of lower water vapor permeability
US4989619A (en) 1985-08-26 1991-02-05 R. J. Reynolds Tobacco Company Smoking article with improved fuel element
AU6541786A (en) 1985-10-09 1987-05-05 Desitin Arzneimittel Gmbh Process for producing an administration or dosage form of drugs, reagents or other active ingredients
US4821745A (en) * 1985-11-14 1989-04-18 Rosen David I Apparatus and method for overcoming the habit of tobacco smoking
US4706692A (en) 1985-12-30 1987-11-17 Philip Morris Incorporated Method and apparatus for coating reconstituted tobacco
US4880018A (en) 1986-02-05 1989-11-14 R. J. Reynolds Tobacco Company Extruded tobacco materials
US4724850A (en) * 1986-02-05 1988-02-16 R. J. Reynolds Tobacco Company Process for providing tobacco extender material
US4764378A (en) 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
GB8704196D0 (en) 1987-02-23 1987-04-01 British American Tobacco Co Tobacco reconstitution
US4708151A (en) 1986-03-14 1987-11-24 R. J. Reynolds Tobacco Company Pipe with replaceable cartridge
US4771795A (en) 1986-05-15 1988-09-20 R. J. Reynolds Tobacco Company Smoking article with dual burn rate fuel element
US4713243A (en) 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
GB8615676D0 (en) 1986-06-26 1986-07-30 Stoppers Co Ltd Nicotine containing lozenge
JPS6368798A (en) * 1986-09-09 1988-03-28 Ebara Corp Submersible pump
JPH0356240Y2 (en) * 1986-10-24 1991-12-17
US4754767A (en) 1986-11-21 1988-07-05 R. J. Reynolds Tobacco Company Tobacco material processing
US4824681A (en) * 1986-12-19 1989-04-25 Warner-Lambert Company Encapsulated sweetener composition for use with chewing gum and edible products
US4911934A (en) * 1986-12-19 1990-03-27 Warner-Lambert Company Chewing gum composition with encapsulated sweetener having extended flavor release
EP0341261A1 (en) 1987-01-15 1989-11-15 Vladimir Dr. Badmajew Anti-smoking agent
US4819665A (en) 1987-01-23 1989-04-11 R. J. Reynolds Tobacco Company Aerosol delivery article
US4907805A (en) * 1987-01-29 1990-03-13 Watkins Derrall W Ring puzzle game
GB8704197D0 (en) * 1987-02-23 1987-04-01 British American Tobacco Co Tobacco reconstitution
GB8713645D0 (en) 1987-06-11 1987-07-15 Imp Tobacco Ltd Smoking device
CN1009801B (en) 1987-08-04 1990-10-03 于劲前 Transportation and accident lifesaving apparatus for high building
US4795641A (en) * 1987-08-20 1989-01-03 Eastman Kodak Company Polymer blends having reverse phase morphology for controlled delivery of bioactive agents
US4917161A (en) * 1987-10-06 1990-04-17 Helme Tobacco Company Chewing tobacco composition and process for producing the same
US4807648A (en) 1987-12-21 1989-02-28 Tripar Incorporated Non-burning tobacco substitute
US4936920A (en) * 1988-03-09 1990-06-26 Philip Morris Incorporated High void volume/enhanced firmness tobacco rod and method of processing tobacco
JPH069497B2 (en) 1988-04-28 1994-02-09 大日精化工業株式会社 Cigarette molding, manufacturing method thereof, and cigarette
US5081158A (en) * 1988-05-02 1992-01-14 Zila Pharmaceuticals, Inc. Compositions and in situ methods for forming films on body tissue
US4985260A (en) * 1988-05-06 1991-01-15 Vitas Niaura Food body with surface color indicia
US4917924A (en) * 1988-12-16 1990-04-17 Viskase Corporation Food body with surface color indicia
US4981522A (en) * 1988-07-22 1991-01-01 Philip Morris Incorporated Thermally releasable flavor source for smoking articles
DE3827561C1 (en) 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
US5244668A (en) 1988-10-14 1993-09-14 Zetachron, Inc. Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith
US4955399A (en) 1988-11-30 1990-09-11 R. J. Reynolds Tobacco Company Smoking article
JPH0645536B2 (en) 1989-01-31 1994-06-15 日東電工株式会社 Oral mucosa patch and oral mucosa patch preparation
CA1328394C (en) 1989-04-03 1994-04-12 Bruce E. Banyai Stable biodegradable foam
EP0399252A3 (en) 1989-05-22 1992-04-15 R.J. Reynolds Tobacco Company Smoking article with improved insulating material
US5089307A (en) * 1989-05-23 1992-02-18 Mitsubishi Rayon Co., Ltd. Edible film and method of making same
US5129409A (en) 1989-06-29 1992-07-14 R. J. Reynolds Tobacco Company Extruded cigarette
DK365389D0 (en) * 1989-07-24 1989-07-24 Fertin Lab As ANTIFUNGAL CHEMICAL GUM PREPARATION
NO168921C (en) * 1989-07-31 1992-04-22 Svein Knudsen SMOKE-FREE Cigarette replacement for use in smoking cessation OR FOR USE IN SMOKE-FREE ENVIRONMENTS
US5824334A (en) 1989-09-05 1998-10-20 University Of Utah Research Foundation Tobacco substitute
US4987906A (en) * 1989-09-13 1991-01-29 R. J. Reynolds Tobacco Company Tobacco reconstitution process
US5101839A (en) * 1990-08-15 1992-04-07 R. J. Reynolds Tobacco Company Cigarette and smokable filler material therefor
US5525351A (en) 1989-11-07 1996-06-11 Dam; Anders Nicotine containing stimulant unit
US5019403A (en) 1989-12-13 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Coatings for substrates including high moisture edible substrates
SE8904295D0 (en) 1989-12-21 1989-12-21 Pharmacia Ab SMOKING SUBSTITUTE
US5099864A (en) * 1990-01-05 1992-03-31 R. J. Reynolds Tobacco Company Tobacco reconstitution process
JPH0740907B2 (en) * 1990-01-30 1995-05-10 日本たばこ産業株式会社 Sheet tobacco manufacturing method and apparatus
DE4005656C2 (en) * 1990-02-22 1994-05-26 Bat Cigarettenfab Gmbh Method and device for producing a tobacco film
US5183062A (en) 1990-02-27 1993-02-02 R. J. Reynolds Tobacco Company Cigarette
DE59004144D1 (en) 1990-04-03 1994-02-17 Paul Braendli Means to stop smoking.
JP3165438B2 (en) 1990-04-04 2001-05-14 バーウィンド・ファーマス―ティカル・サーヴィスィーズ・インコーポレーテッド Aqueous maltodextrin and cellulose polymer film coating
GB9009390D0 (en) 1990-04-26 1990-06-20 Smith Kline French Lab Pharmaceutical compositions
US5307821A (en) 1990-04-27 1994-05-03 Asahi Glass Company Ltd. Tobacco raw material and method for its production
DE4018247A1 (en) 1990-06-07 1991-12-12 Lohmann Therapie Syst Lts MANUFACTURING METHOD FOR QUICK-DISINFITTING FILM-SHAPED PHARMACEUTICAL FORMS
US5186185A (en) * 1990-07-06 1993-02-16 Japan Tobacco Inc. Flavoring granule for tobacco products and a preparation method thereof
US5240014A (en) 1990-07-20 1993-08-31 Philip Morris Incorporated Catalytic conversion of carbon monoxide from carbonaceous heat sources
US5484604A (en) * 1990-07-21 1996-01-16 Chatfield Pharmaceuticals Limited Cross-linked alginate transdermal medicine delivery devices
US5147654A (en) 1990-07-23 1992-09-15 Alza Corporation Oral osmotic device for delivering nicotine
US5048544A (en) 1990-08-10 1991-09-17 Robert Mascarelli Cigarette substitute
US5327917A (en) 1990-08-15 1994-07-12 R. J. Reynolds Tobacco Company Method for providing a reconstituted tobacco material
US5105837A (en) 1990-08-28 1992-04-21 R. J. Reynolds Tobacco Company Smoking article with improved wrapper
US5488962A (en) * 1990-10-10 1996-02-06 Perfetti, S.P.A. Chewing gum which is a substitute for tobacco smoke
US5144967A (en) 1990-10-22 1992-09-08 Kimberly-Clark Corporation Flavor release material
US5144966A (en) 1990-12-11 1992-09-08 Philip Morris Incorporated Filamentary flavorant-release additive for smoking compositions
US5247949A (en) 1991-01-09 1993-09-28 Philip Morris Incorporated Method for producing metal carbide heat sources
US5205106A (en) 1991-03-04 1993-04-27 General Mills, Inc. Rolled food item fabricating apparatus and methods
US5135753A (en) 1991-03-12 1992-08-04 Pharmetrix Corporation Method and therapeutic system for smoking cessation
US5240016A (en) 1991-04-19 1993-08-31 Philip Morris Incorporated Thermally releasable gel-based flavor source for smoking articles
GB9108604D0 (en) * 1991-04-22 1991-06-05 Nadreph Ltd Gel products and a process for making them
US5146934A (en) 1991-05-13 1992-09-15 Philip Morris Incorporated Composite heat source comprising metal carbide, metal nitride and metal
USD335934S (en) 1991-05-16 1993-05-25 Howard Ralph E Tobacco-impregnated toothpick
GB9111148D0 (en) 1991-05-23 1991-07-17 British American Tobacco Co Improvements relating to polymer viscosity and application of such polymers
DE4117307C1 (en) 1991-05-27 1992-06-04 B.A.T. Cigarettenfabriken Gmbh, 2000 Hamburg, De
US5197494A (en) * 1991-06-04 1993-03-30 R.J. Reynolds Tobacco Company Tobacco extraction process
US5178167A (en) 1991-06-28 1993-01-12 R. J. Reynolds Tobacco Company Carbonaceous composition for fuel elements of smoking articles and method of modifying the burning characteristics thereof
JPH0524353A (en) 1991-07-25 1993-02-02 Ricoh Co Ltd Heat-sensitive recording paper
AU3070892A (en) * 1991-11-12 1993-06-15 Nepera, Inc. Adhesive hydrogels having extended use lives and process for the preparation of same
SE9103366L (en) 1991-11-14 1993-03-15 Gudmar Olovson DEVICE FOR SMOKING WASTE
JP3232488B2 (en) 1992-08-20 2001-11-26 株式会社林原生物化学研究所 High content of pullulan, its production method and use
US5358765A (en) 1992-03-04 1994-10-25 Viskase Corporation Cellulosic article containing an olefinic oxide polymer and method of manufacture
US5286502A (en) 1992-04-21 1994-02-15 Wm. Wrigley Jr. Company Use of edible film to prolong chewing gum shelf life
US5393528A (en) * 1992-05-07 1995-02-28 Staab; Robert J. Dissolvable device for contraception or delivery of medication
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5800647A (en) 1992-08-11 1998-09-01 E. Khashoggi Industries, Llc Methods for manufacturing articles from sheets having a highly inorganically filled organic polymer matrix
US5783126A (en) * 1992-08-11 1998-07-21 E. Khashoggi Industries Method for manufacturing articles having inorganically filled, starch-bound cellular matrix
US5508072A (en) 1992-08-11 1996-04-16 E. Khashoggi Industries Sheets having a highly inorganically filled organic polymer matrix
US5810961A (en) 1993-11-19 1998-09-22 E. Khashoggi Industries, Llc Methods for manufacturing molded sheets having a high starch content
US5411945A (en) 1992-08-29 1995-05-02 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pullulan binder and its uses
CN1072579A (en) * 1992-09-28 1993-06-02 李瀚旻 Disposable micro-multistage liquid containing filter tip for cigarette
FR2699406B1 (en) 1992-12-21 1995-03-10 Commissariat Energie Atomique Films based on copolymers, their applications in transdermal systems and their preparation processes.
US5441060A (en) 1993-02-08 1995-08-15 Duke University Dry powder delivery system
US5411746A (en) * 1993-02-24 1995-05-02 Warner-Jenkinson Company, Inc. Dye compositions and methods for film coating tablets and the like
US6001346A (en) 1993-02-25 1999-12-14 The Regents Of The University Of California Aqueous emulsion comprising biodegradable carrier for insect pheromones and methods for controlled release thereof
JPH0744622U (en) * 1993-03-30 1995-11-28 忠司 徳山 Candy with pipe
JPH0744622A (en) 1993-06-29 1995-02-14 Sharp Corp Table calculating device
US6616958B1 (en) 1993-07-07 2003-09-09 Jack Guttman, Inc. Method of making and using an edible film for decorating foodstuffs
US5520924A (en) 1993-07-09 1996-05-28 Mizu Systems Corporation Methods and articles for administering drug to the oral cavity
IT1266565B1 (en) * 1993-07-22 1997-01-09 Ct Lab Farm Srl PHARMACEUTICAL COMPOSITIONS WITH CONTROLLED RELEASE ON THE BASIS OF ONE OR MORE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE RANGE-HYDROXY-BUTYRIC ACID.
US5387416A (en) * 1993-07-23 1995-02-07 R. J. Reynolds Tobacco Company Tobacco composition
US5549906A (en) 1993-07-26 1996-08-27 Pharmacia Ab Nicotine lozenge and therapeutic method for smoking cessation
DE59409600D1 (en) 1993-07-31 2001-01-11 Hauni Maschinenbau Ag Conveyor device for producing a tobacco monolayer
US5362496A (en) * 1993-08-04 1994-11-08 Pharmetrix Corporation Method and therapeutic system for smoking cessation
AU675573B2 (en) 1993-09-30 1997-02-06 British-American Tobacco Company Limited Improvements relating to tobacco smoke filter elements
SE9303574D0 (en) 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method of manufacturing thereof
FR2712094B1 (en) 1993-11-02 1995-12-01 Thomson Csf Method for determining the range of ambiguity in distance from radar echoes.
US6083586A (en) 1993-11-19 2000-07-04 E. Khashoggi Industries, Llc Sheets having a starch-based binding matrix
DE4341442C2 (en) 1993-12-04 1998-11-05 Lohmann Therapie Syst Lts Device for the controlled release of active substances and their use
CN1037317C (en) 1994-01-13 1998-02-11 孙来顺 Health-type chewing tobacco
US5547693A (en) 1994-03-02 1996-08-20 The Regents Of The University Of California Method of preserving natural color on fresh and minimally processed fruits and vegetables
US5599583A (en) * 1994-05-27 1997-02-04 Micro Flo Company Encapsulation with water soluble polymer
US5543164A (en) 1994-06-17 1996-08-06 The Regents Of The University Of California Water-insoluble protein-based edible barrier coatings and films
NL9401037A (en) 1994-06-23 1996-02-01 Soonn Stichting Onderzoek En O Process for preparing a biodegradable polyhydroxyalkanoate coating using an aqueous dispersion of polyhydroxyalkanoate.
MA23587A1 (en) 1994-06-23 1995-12-31 Procter & Gamble TREATMENT OF NEED FOR NICOTINE AND / OR SMOKING-RELATED SYNDROME
WO1996000072A1 (en) * 1994-06-23 1996-01-04 The Procter & Gamble Company Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine
GB9414889D0 (en) 1994-07-23 1994-09-14 Imp Tobacco Co Ltd Tobacco reconstitution
US5533530A (en) 1994-09-01 1996-07-09 R. J. Reynolds Tobacco Company Tobacco reconstitution process
CN1507818A (en) 1994-09-07 2004-06-30 Ӣ���̲�(Ͷ��)���޹�˾ Cigarette fuel, aerosol generating agent for the cigurette and aerosol generating fuel and said cigarett product
US5666979A (en) * 1994-09-29 1997-09-16 Chase; Gene Cigar substitute
US5584306A (en) 1994-11-09 1996-12-17 Beauman; Emory Reconstituted tobacco material and method of its production
US5810018A (en) 1994-12-29 1998-09-22 Monte; Woodrow C. Method, composition and apparatus for reducing the incidence of cigarette smoking
DE19500977C2 (en) 1995-01-14 1999-01-07 Lohmann Therapie Syst Lts Solid drug form with active ingredient distributed in polymeric material
DE19503336C2 (en) 1995-02-02 1998-07-30 Lohmann Therapie Syst Lts Pharmaceutical form for delivering active substances to wounds, process for their preparation and their use
US6082368A (en) 1995-05-08 2000-07-04 Brown; Graham H. Nicotine candy cigarette
CH689198A5 (en) 1995-08-30 1998-12-15 Hanspeter Baldauf Toothpick.
US5811126A (en) 1995-10-02 1998-09-22 Euro-Celtique, S.A. Controlled release matrix for pharmaceuticals
JP2791317B2 (en) 1995-12-26 1998-08-27 株式会社三和化学研究所 Multilayer film preparation
US5747648A (en) 1996-03-12 1998-05-05 Midwest Grain Products Modified wheat glutens and use thereof in fabrication of films
TR199802068T2 (en) 1996-04-16 2000-01-21 Novartis Consumer Health S.A. Quick release oral dosage form.
JP3707798B2 (en) 1996-05-13 2005-10-19 ノバルティス・コンシューマー・ヘルス・ソシエテ・アノニム Intraoral drug delivery system
JPH1043211A (en) 1996-08-07 1998-02-17 Kenichi Suzuki Manufacturing method and device for toothpick
SE506146C2 (en) 1996-08-26 1997-11-17 Swedish Match Sverige Ab Device for packaging of finely divided, moistened tobacco material
WO1998009537A1 (en) 1996-09-09 1998-03-12 Kiwitech Limited Acid casein or a non-toxic soluble salt thereof and high-methoxyl pectin polymer
CN2256216Y (en) * 1996-09-29 1997-06-18 赵康修 Smoking article
US5800832A (en) 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
DE19646392A1 (en) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Preparation for use in the oral cavity with a layer containing pressure-sensitive adhesive, pharmaceuticals or cosmetics for dosed delivery
US5817381A (en) 1996-11-13 1998-10-06 Agricultural Utilization Research Institute Cellulose fiber based compositions and film and the process for their manufacture
US6083582A (en) 1996-11-13 2000-07-04 Regents Of The University Of Minnesota Cellulose fiber based compositions and film and the process for their manufacture
DE19704737A1 (en) 1997-02-07 1998-08-13 Kalle Nalo Gmbh Edible moldings, especially flat and tubular films
US5845648A (en) * 1997-06-03 1998-12-08 Martin; John E. Multi-compartment expandable filter for a smoking product
CA2296654A1 (en) 1997-07-23 1999-02-04 Perio Products Ltd. Tannic acid-polymer compositions for controlled release of pharmaceutical agents, particularly in the oral cavity
SE9703458D0 (en) 1997-09-25 1997-09-25 Pharmacia & Upjohn Ab Nicotine compositions and methods of formulation thereof
US20030176467A1 (en) 1997-09-25 2003-09-18 Sven Andersson Nicotine compositions
JP3460538B2 (en) 1997-10-08 2003-10-27 救急薬品工業株式会社 Fast dissolving film preparation
JP2001522796A (en) 1997-11-12 2001-11-20 ザ ダウ ケミカル カンパニー Free-flowing, dust-free, cold-water dispersible edible thin coating composition
US5908034A (en) 1997-12-08 1999-06-01 Brown & Williamson Tobacco Corporation Method for making a band cast reconstituted tobacco sheet using steam exploded tobacco
US5947128A (en) 1997-12-08 1999-09-07 Brown & Williamson Tobacco Corporation Method for making a reconstituted tobacco sheet using steam exploded tobacco
US6082370A (en) 1998-02-09 2000-07-04 Rousseau Research, Inc. Cigarette with dry powered Vitamin E
JP2002501768A (en) 1998-02-09 2002-01-22 ルソー リサーチ， インコーポレイテッド Tobacco products with vitamin E
US5962053A (en) 1998-02-17 1999-10-05 Viskase Corporation Edible film and method
US20020008751A1 (en) 1998-03-25 2002-01-24 Stephen L. Spurgeon Decorating system for edible items
US6211194B1 (en) 1998-04-30 2001-04-03 Duke University Solution containing nicotine
US6273095B1 (en) * 1998-07-20 2001-08-14 Jong-Pyng Hsu Cigarette filter which removes carcinogens and toxic chemicals
US6344222B1 (en) * 1998-09-03 2002-02-05 Jsr Llc Medicated chewing gum delivery system for nicotine
US20030211136A1 (en) 1998-09-25 2003-11-13 Neema Kulkarni Fast dissolving orally consumable films containing a sweetener
US6596298B2 (en) * 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US20030206942A1 (en) 1998-09-25 2003-11-06 Neema Kulkarni Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent
US6224897B1 (en) 1998-09-29 2001-05-01 Novartis Consumer Health S.A. Methods to abate the use of tobacco by humans
SE9803986D0 (en) * 1998-11-23 1998-11-23 Pharmacia & Upjohn Ab New compositions
IL127396A0 (en) 1998-12-03 1999-10-28 Univ Ben Gurion A sustained-release polysaccharide-protein water insoluble bead and a process for preparing the same
US6627234B1 (en) 1998-12-15 2003-09-30 Wm. Wrigley Jr. Company Method of producing active agent coated chewing gum products
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6041789A (en) * 1999-01-28 2000-03-28 K&B Technologies, L.L.C. Cigarette substitute device and composition for use therein
US6723342B1 (en) 1999-02-08 2004-04-20 Fmc Corporation Edible coating composition
US6432448B1 (en) * 1999-02-08 2002-08-13 Fmc Corporation Edible coating composition
US6210699B1 (en) * 1999-04-01 2001-04-03 Watson Pharmaceuticals, Inc. Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity
US6248760B1 (en) 1999-04-14 2001-06-19 Paul C Wilhelmsen Tablet giving rapid release of nicotine for transmucosal administration
US6583160B2 (en) 1999-04-14 2003-06-24 Steve Smith Nicotine therapy method and oral carrier for assuaging tobacco-addiction
GB9910505D0 (en) 1999-05-06 1999-07-07 Electrosols Ltd A method and apparatus for manufacturing consumable tablets
US6231957B1 (en) 1999-05-06 2001-05-15 Horst G. Zerbe Rapidly disintegrating flavor wafer for flavor enrichment
DE19925613A1 (en) 1999-06-04 2000-12-07 Lohmann Therapie Syst Lts Composite laminate and process for its manufacture
EP1204699B1 (en) 1999-07-22 2005-06-08 Warner-Lambert Company LLC Pullulan film compositions
US6117096A (en) * 1999-08-19 2000-09-12 Hassard; Peter K. Lower spine protector
US6280769B1 (en) 1999-09-13 2001-08-28 Nabisco, Inc. Breath freshening comestible product
US6379726B1 (en) * 1999-10-20 2002-04-30 The United States Of America As Represented By The Department Of Agriculture Edible, water-solubility resistant casein masses
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US6500462B1 (en) 1999-10-29 2002-12-31 Fmc Corporation Edible MCC/PGA coating composition
US6326022B1 (en) 1999-11-04 2001-12-04 Harry S. Katz Slow-release disposable elastomeric buccal devices
DE19954245A1 (en) * 1999-11-11 2001-07-19 Lohmann Therapie Syst Lts Multi-layer film-like preparation made of hydrophilic polymers for the rapid release of active ingredients
WO2001037814A1 (en) 1999-11-23 2001-05-31 Robert Gordon University Bilayered buccal tablets comprising nicotine
US6742525B2 (en) 1999-12-07 2004-06-01 Blunt Wrap U.S.A., Inc. Tobacco product
EP1120109A3 (en) 2000-01-24 2002-07-10 Pfizer Products Inc. Rapidly disintegrating and fast dissolving solid dosage form
US7067116B1 (en) 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
US6936291B1 (en) 2000-03-28 2005-08-30 Michael K. Weibel Method of producing edible cellulosic films
US6749882B2 (en) 2000-05-17 2004-06-15 Stephen Fortune, Jr. Coffee having a nicotine composition dissolved therein
AU2001261744A1 (en) * 2000-05-19 2001-12-03 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
US6528088B1 (en) 2000-06-01 2003-03-04 A. E. Staley Manufacturing Co. Highly flexible starch-based films
CN1536989A (en) 2000-06-30 2004-10-13 Oral compositions comprising host-respones modulating agent for promoting whole body health
US20020022057A1 (en) * 2000-08-17 2002-02-21 Battey Alyce S. Oral delivery of pharmaceuticals via encapsulation
US6660302B1 (en) 2000-09-06 2003-12-09 Chr. Hansen, Inc. Dry-powder film coating composition and method of preparation
US6576298B2 (en) 2000-09-07 2003-06-10 Ecolab Inc. Lubricant qualified for contact with a composition suitable for human consumption including a food, a conveyor lubrication method and an apparatus using droplets or a spray of liquid lubricant
US20020119192A1 (en) 2000-09-22 2002-08-29 Vishwanathan Narayanan Badri Controlled release formulations for oral administration
JP2004512907A (en) 2000-11-03 2004-04-30 リカバリー　ファーマシューティカルズ　インコーポレーティッド Device and method for smoking cessation
WO2002043694A2 (en) 2000-11-28 2002-06-06 Fmc Corporation Edible pga(propylene glycol alginate) coating composition
US6932861B2 (en) 2000-11-28 2005-08-23 Fmc Corporation Edible PGA coating composition
US20020131990A1 (en) 2000-11-30 2002-09-19 Barkalow David G. Pullulan free edible film compositions and methods of making the same
US6479076B2 (en) 2001-01-12 2002-11-12 Izhak Blank Nicotine delivery compositions
WO2002063982A1 (en) 2001-02-09 2002-08-22 New Chapter, Inc. Composition and method for smoke detoxification
US7125564B2 (en) 2001-02-16 2006-10-24 Lavipharm Laboratories, Inc. Water soluble and palatable complexes
JP4354700B2 (en) 2001-03-23 2009-10-28 ガムリンク エー／エス Coated degradable chewing gum with improved shelf life and process for its preparation
FR2822471B1 (en) * 2001-03-26 2003-06-13 Roquette Freres METHOD OF COOKING / DRYING AMYLOSE-RICH STARCHES
JP2004525928A (en) 2001-03-26 2004-08-26 スミスクライン・ビーチャム・コーポレイション Nicotine-containing oral dosage form
US20020170567A1 (en) 2001-04-06 2002-11-21 John Rizzotto Chewable flavor delivery system
CA2449415A1 (en) * 2001-04-20 2002-10-31 Lavipharm Laboratories Inc. Intraoral delivery of nicotine for smoking cessation
AU2002255267B2 (en) 2001-04-24 2007-12-20 Lintec Corporation An orally administered agent and an orally administered agent/supporting substrate complex
OA12601A (en) 2001-05-01 2006-06-09 Jonnie R Williams Smokeless tobacco product.
US6668839B2 (en) * 2001-05-01 2003-12-30 Jonnie R. Williams Smokeless tobacco product
US20040020503A1 (en) * 2001-05-01 2004-02-05 Williams Jonnie R. Smokeless tobacco product
US6899897B2 (en) * 2001-06-18 2005-05-31 Jaleva, Inc. Gum resin as a carrier for topical application of pharmacologically active agents
US6660292B2 (en) * 2001-06-19 2003-12-09 Hf Flavoring Technology Llp Rapidly disintegrating flavored film for precooked foods
US6656493B2 (en) * 2001-07-30 2003-12-02 Wm. Wrigley Jr. Company Edible film formulations containing maltodextrin
US6419903B1 (en) 2001-08-20 2002-07-16 Colgate Palmolive Company Breath freshening film
JP5089840B2 (en) 2001-09-25 2012-12-05 救急薬品工業株式会社 Nicotine-containing film preparation
SE0103211D0 (en) 2001-09-27 2001-09-27 Pharmacia Ab New formulations and use thereof
SE0103210D0 (en) 2001-09-27 2001-09-27 Pharmacia Ab New formulations and use thereof
US20040062804A1 (en) 2001-09-28 2004-04-01 Der-Yang Lee Modified release dosage forms
US7032601B2 (en) 2001-09-28 2006-04-25 U.S. Smokeless Tobacco Company Encapsulated materials
US6953040B2 (en) 2001-09-28 2005-10-11 U.S. Smokeless Tobacco Company Tobacco mint plant material product
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7666337B2 (en) * 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
DE60105820D1 (en) * 2001-10-22 2004-10-28 Pera Ivo E Composition for reducing or weaning nicotine addiction
US20030111088A1 (en) 2001-10-29 2003-06-19 Addiction Therapies, Inc. Device and method for treating combination dependencies
US20040037879A1 (en) 2001-11-02 2004-02-26 Adusumilli Prasad S. Oral controlled release forms useful for reducing or preventing nicotine cravings
ATE398465T1 (en) 2001-11-16 2008-07-15 Givaudan Sa EDIBLE FILM
US20030099691A1 (en) 2001-11-16 2003-05-29 Susan Lydzinski Films containing starch
GB0130627D0 (en) 2001-12-21 2002-02-06 British American Tobacco Co Improvements relating to smokable filler materials
US7887838B2 (en) * 2002-01-18 2011-02-15 Banner Pharmacaps, Inc. Non-gelatin film and method and apparatus for producing same
US20030224090A1 (en) 2002-02-11 2003-12-04 Edizone, Lc Snacks of orally soluble edible films
US20050008735A1 (en) * 2002-02-11 2005-01-13 Pearce Tony M. Chocolate polymer snacks
US20040247744A1 (en) 2002-02-11 2004-12-09 Edizone, Lc Vitamin-containing orally soluble films
US20040247649A1 (en) 2002-02-11 2004-12-09 Edizone, Lc Medicine-containing orally soluble films
US7105173B1 (en) 2002-03-21 2006-09-12 Rolling Kenneth J Nicotine replacement applique
JP2003310179A (en) 2002-04-19 2003-11-05 Ajinomoto Co Inc Nutraceutical chips and method for producing the same
KR20030089047A (en) 2002-05-16 2003-11-21 주식회사 엘지생활건강 Composition for enhancing oral health
US20030235630A1 (en) 2002-06-21 2003-12-25 Nussen Kenneth H. Dental hygiene products and methods of making dental hygiene products
US7347985B2 (en) 2002-06-25 2008-03-25 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product with magnolia bark extract
US7632525B2 (en) * 2002-06-25 2009-12-15 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents
US20040086546A1 (en) 2002-06-25 2004-05-06 Maxwell James Roy Breath freshening and oral cleansing product with cinnamaldehyde
AU2003261187B2 (en) 2002-07-18 2009-10-22 Phasex Corporation Reduction of constituents in tobacco
CA2505796C (en) 2002-07-22 2012-01-03 Monosolrx Llc Packaging and dispensing of rapid dissolve dosage form
US20040018156A1 (en) 2002-07-23 2004-01-29 Szeles Lori H Enzyme enhanced breath freshening film
WO2004019802A2 (en) 2002-08-27 2004-03-11 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product using carvacrol
US20040043134A1 (en) * 2002-08-27 2004-03-04 Corriveau Christine Leclair Rolled edible thin film products and methods of making same
CA2495793A1 (en) 2002-08-27 2004-03-11 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product using cardamom oil
AU2003262879A1 (en) 2002-08-27 2004-03-19 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product using salicylaldehyde
WO2004019922A1 (en) 2002-08-27 2004-03-11 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product using citral
AU2003262882A1 (en) 2002-08-27 2004-03-19 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product using geraniol
CA2495057A1 (en) 2002-08-27 2004-03-11 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product
AU2003268262A1 (en) 2002-08-29 2004-03-19 Linguagen Corp. Fast dissolving film delivery of nucleotides that inhibit the unpleasant taste of bitter tasting medications
US20040120991A1 (en) 2002-09-07 2004-06-24 Mars Incorporated Edible films having distinct regions
US20040052853A1 (en) * 2002-09-16 2004-03-18 Cp Kelco, U.S., Inc. Pectin films
US20040107971A1 (en) 2002-09-17 2004-06-10 Abhijit De Gum based chewing product and process for preparing the same
AU2003275875A1 (en) 2002-10-30 2004-05-25 Reg Macquarrie Edible dissolving gelatin strips
AU2002350090A1 (en) 2002-10-31 2004-06-07 Recovery Pharmaceuticals, Inc. Device and method for treating combination dependencies
ITMI20022343A1 (en) 2002-11-05 2004-05-06 Biofarm Srl FAST DISSOLUTION FILM IN WATER, CONTAINING COSMETIC, AROMATIC, PHARMACEUTICAL OR FOOD SYSTEMS.
AU2003277788A1 (en) 2002-11-14 2004-06-03 Givaudan Sa Edible film containing food acid
CA2505833A1 (en) 2002-11-14 2004-06-03 Innozen, Inc. Edible film for relief of cough or symptoms associated with pharyngitis
US20040131662A1 (en) 2003-11-12 2004-07-08 Davidson Robert S. Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
US20040141927A1 (en) 2002-11-14 2004-07-22 Johnson Sonya S. Oral products containing novel flavor composition
US20040096569A1 (en) 2002-11-15 2004-05-20 Barkalow David G. Edible film products and methods of making same
US20050039767A1 (en) * 2002-11-19 2005-02-24 John-Paul Mua Reconstituted tobacco sheet and smoking article therefrom
US20050056294A1 (en) * 2002-11-19 2005-03-17 Wanna Joseph T. Modified reconstituted tobacco sheet
US20040115137A1 (en) 2002-12-17 2004-06-17 Verrall Andrew P. Water-soluble film for oral administration
US20040118421A1 (en) 2002-12-19 2004-06-24 Swedish Match North Europe Ab New product and a method for its manufacture
US20040118422A1 (en) 2002-12-19 2004-06-24 Swedish Match North Europe Ab Tobacco dough and a method for its manufacture
DK1575383T3 (en) 2002-12-19 2009-08-03 Swedish Match North Europe Ab Moist snuff tobacco composition comprising at least one thickener and a process for making it
JP4708795B2 (en) 2002-12-20 2011-06-22 ニコノヴァム エービー Physically and chemically stable nicotine-containing particulate matter
WO2004058231A2 (en) 2002-12-26 2004-07-15 University Of Manitoba Dissolving film comprising a therapeutically active agent within the film or in a pouch formed by the film
US20040208931A1 (en) 2002-12-30 2004-10-21 Friend David R Fast dissolving films for oral administration of drugs
US20040156794A1 (en) 2003-02-11 2004-08-12 Barkalow David G. Bioerodible and bioadhesive confectionery products and methods of making same
JP2006518388A (en) 2003-02-20 2006-08-10 ビーピーエスアイ ホールディングス，インコーポレーテッド Nacreous film coating system and substrate coated thereby
US20040166214A1 (en) 2003-02-20 2004-08-26 Gesford Pamela K. Film coatings containing pearlescent pigments and edible articles coated therewith
US20040180110A1 (en) 2003-03-14 2004-09-16 Atul Mistry Chewing gum and confectionery compositions containing an endothermic agent
CN1764434A (en) 2003-03-26 2006-04-26 宝洁公司 Rapidly dissolving edible film compositions with cellulose film forming polymers
EP1605908A2 (en) 2003-03-26 2005-12-21 The Procter & Gamble Company Rapidly dissolving edible film compositions with improved film strength and stability
US20040202698A1 (en) 2003-04-02 2004-10-14 The Procter & Gamble Company Drug delivery systems comprising an encapsulated active ingredient
AU2004233744A1 (en) 2003-05-02 2004-11-11 Warner-Lambert Company Llc Fast dissolving orally consumable films containing a modified starch for improved heat and moisture resistance
US20040241294A1 (en) 2003-05-31 2004-12-02 Barabolak Roman M. Edible films including aspartame and methods of making same
US20040258630A1 (en) 2003-06-23 2004-12-23 Boyd Thomas J. Antiplaque breath freshening consumable film
US20050088632A1 (en) 2003-07-21 2005-04-28 Sadi Sonja J. Vitasolve dissolving film strips with supplements pharmaceutical drug(RX), +vitamins
US20050058609A1 (en) * 2003-07-22 2005-03-17 Alireza Nazeri Medicated toothpick
AU2004259006B2 (en) 2003-07-24 2010-10-07 Glaxosmithkline Llc Orally dissolving films
US20050031775A1 (en) * 2003-08-07 2005-02-10 Charles Signorino High gloss film coating and stable solution therefor
ATE422355T1 (en) 2003-09-08 2009-02-15 Mcneil Ab NICOTINE FORMULATIONS AND THEIR USE
US20050123502A1 (en) 2003-10-07 2005-06-09 Chan Shing Y. Nicotine containing oral compositions
US20050079253A1 (en) 2003-10-10 2005-04-14 Hiroshi Nakamura Bilayer edible sheet
JP3870241B2 (en) 2003-10-10 2007-01-17 株式会社スズパック Flaky packaging
US7901512B2 (en) 2003-11-03 2011-03-08 U.S. Smokeless Tobacco Company Flavored smokeless tobacco and methods of making
AU2004289248B2 (en) 2003-11-07 2012-05-03 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US7182964B2 (en) 2003-11-13 2007-02-27 Dbc, Llc Dissolving thin film xanthone supplement
US20050207993A1 (en) 2003-11-13 2005-09-22 Russel Bazemore Method and composition for breath freshening
KR20050048056A (en) 2003-11-18 2005-05-24 (주)케이비피 Composition for oral consumable film
KR20070007299A (en) 2004-01-30 2007-01-15 코리움 인터네셔널, 인크. Rapidly dissolving film for delivery of an active agent
US20050186257A1 (en) 2004-02-20 2005-08-25 Todd Manegold Dissolvable film and method of manufacture
US20050186256A1 (en) 2004-02-20 2005-08-25 Dihel Deborah L. Dissolvable film comprising an active ingredient and method of manufacture
DE102004021114A1 (en) 2004-04-29 2005-12-29 Reemtsma Cigarettenfabriken Gmbh Fine-cut partial quantity packing and method for producing fine-cut partial quantity packages
AU2005265249A1 (en) * 2004-06-22 2006-01-26 E-L Management Corp. Dissolvable film composition
WO2006012213A2 (en) * 2004-06-25 2006-02-02 Tea Guard Llc Composition and method for delivery of phytochemicals
ATE438390T1 (en) 2004-07-02 2009-08-15 Radi Medical Biodegradable Ab SMOKELESS TOBACCO PRODUCT
US20060024425A1 (en) * 2004-07-30 2006-02-02 Wm. Wrigley Jr. Company Edible film compositions
JP2008510486A (en) * 2004-08-23 2008-04-10 ユーエス スモークレス タバコ カンパニー Tobacco with diversity
RU2007106564A (en) * 2004-09-02 2008-10-10 Дзе Проктер Энд Гэмбл Компани (US) ORGANIC CARE COMPOSITION, INCLUDING ESSENTIAL OILS
WO2006065192A1 (en) 2004-11-12 2006-06-22 Swedish Match North Europe Ab A new oral tobacco product
US7097669B2 (en) 2004-11-18 2006-08-29 Milliken & Company Colorant compositions
CN101222861B (en) 2005-04-29 2010-09-08 菲利普莫里斯生产公司 Tobacco pouch product
WO2007037962A1 (en) 2005-09-22 2007-04-05 R.J. Reynolds Tobacco Company Smokeless tobacco composition
EP1928259A2 (en) 2005-09-30 2008-06-11 Wm. Wrigley Jr. Company Oral composition and method for stress reduction associated with smoking cessation
US7946296B2 (en) 2006-05-26 2011-05-24 Philip Morris Usa Inc. Dissolvable tobacco film strips and method of making the same
WO2007144687A1 (en) 2006-06-12 2007-12-21 Philip Morris Products S.A. Non-tobacco pouch product
JP5941609B2 (en) 2006-08-01 2016-06-29 アール・ジェイ・レノルズ・タバコ・カンパニーＲ．Ｊ．Ｒｅｙｎｏｌｄｓ Ｔｏｂａｃｃｏ Ｃｏｍｐａｎｙ Smokeless tobacco
GB0622252D0 (en) 2006-11-08 2006-12-20 British American Tobacco Co Materials and method for agglomeration of tobacco particles
JP3210945U (en) 2017-03-31 2017-06-15 ヒサ 中田 Buddhist robe

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935604A (en) * 1993-05-20 1999-08-10 Danbiosyst Uk Limited Nasal drug delivery composition containing nicotine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020207736A1 (en) * 2019-04-08 2020-10-15 Philip Morris Products S.A. Method of manufacturing an aerosol-generating film
US12053013B2 (en) 2019-04-08 2024-08-06 Philip Morris Products S.A. Method of manufacturing an aerosol-generating film

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