KR101998288B1 - Composition for smokeless tobacco and orally dissolving film-type smokeless tobacco comprising the same - Google Patents

Abstract

The present invention relates to a smokeless tobacco composition and an orally dissolving film-type smokeless tobacco comprising the same and, more specifically, to an orally dissolving film-type smokeless tobacco composition which can reduce harmfulness to the human body and can improve oral absorption rate of nicotine, moldability and preference, to an orally dissolving film-type smokeless tobacco comprising the same, and to a manufacturing method thereof. The smokeless tobacco composition comprises 0.01-2.5 parts by weight of liquid nicotine with purity over 99%, 40-60 parts by weight of hydroxypropyl methylcellulose or hydroxypropyl cellulose and 2-5 parts by weight of a plasticizer.

Description

TECHNICAL FIELD The present invention relates to a composition for smokeless tobacco and an orally dissolvable film-type smokeless tobacco comprising the same,

The present invention relates to a composition for smokeless tobacco and an oral dissolution film type smokeless cigarette comprising the same. More specifically, the present invention relates to a composition for smokeless tobacco of oral dissolution film type, which can improve absorption rate, formability and preference of nicotine in oral cavity while lowering the harmfulness to human body, oral dry film type smokeless tobacco containing the same, .

The development of smokeless cigarettes has been actively promoted due to the fact that the seriousness of the damage caused by secondhand smoke is widely known and the social environment changes where the smoking area is reduced. However, traditional smokeless tobacco, such as wet snuff, is considered damp and dirty and its use is negative.

In recent years, there have been developed products which can release nicotine in a user's mouth in the form of a network, a film or a sheet, as a kind of smokeless tobacco.

However, the conventional lead-free cigarette contains tobacco particles as a main component and contains many substances harmful to human body such as tar, in addition to nicotine, and there is a problem that the precipitate remains because it is not completely dissolved. Further, at the time of manufacturing the conventional smokeless tobacco, the high temperature treatment step of 100 ° C or more has been required to dissolve the tobacco particles. Furthermore, the conventional smokeless tobacco has a high bitter taste and a low preference degree because it contains a high content of tobacco components. In addition, the conventional lead-free cigarette has a disadvantage in that it is formed into a laminate or a non-aqueous composition is extruded or melted at a high temperature, thereby complicating the manufacturing process, increasing the process cost, and lowering the productivity.

On the other hand, Oral Dissolving Film (ODF) generally refers to a formulation that is dissolved and put into the oral cavity such as on the tongue, under the oral mucosa or under the tongue. It is a product that is not harmful to human body like starch, (Edible Film) mixed with a substance which is beneficial to the human body. These oral dissolution films have the advantage of being water-free and portable.

The edible film is prepared by adding plasticizers, emulsifiers, sweeteners, acidifiers, flavors and other additives based on water-soluble polymers such as pullulan, sodium alginate, pectin, gelatin, carrageenan, xanthan gum and locust starch gum.

Conventional oral dissolving film is prepared by coating the base film with a liquid base material and drying it, then winding it in a roll form or storing it in a roll form, or slitting it by transferring it to a packing machine, cutting it to a size considering the surface area of the film, Packaging and sealing. Therefore, the conventional oral dissolution film has a large number of manufacturing steps, and there is a disadvantage that semi-finished product inventory is generated by storing in the form of a roll, resulting in cost increase due to deterioration of productivity and inventory burden, and hygiene management is additionally required.

Korean Patent Laid-Open No. 10-2012-0087937 discloses a wet smoking lead-free tobacco product having a reticulated gel coating and a method for producing the same.

A number of patent documents are referenced and cited throughout the present invention. The disclosures of the cited patent documents are hereby incorporated by reference into the present invention in its entirety to better illustrate the state of the art to which the present invention pertains and the content of the present invention.

It is an object of the present invention to provide a composition for a smokeless tobacco which can reduce harmfulness to human body and improve moldability and preference of film-type smokeless tobacco.

Another object of the present invention is to provide an orally dissolvable film-type smokeless cigarette having short oral disintegration time and improved oral cavity absorption rate of nicotine.

It is still another object of the present invention to provide a method of manufacturing an orally dissolvable film type smokeless tobacco which is simple in process and excellent in productivity.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

According to one aspect, 0.01-2.5 parts by weight of liquid nicotine having a purity of 99% or more;
40 to 60 parts by weight of hydroxypropylmethylcellulose or hydroxypropylcellulose; And
2 to 5 parts by weight of a plasticizer; and a first region formed by coating a composition for a smokeless tobacco in the form of a film,
There is provided a smokeless tobacco which is an oral dissolution film type further comprising a second region formed by coating a flavoring composition, a functional food composition, a cosmetic composition, a pharmaceutical composition or a mixture thereof in a film form adjacent to the first region.

delete

delete

delete

According to one embodiment, the composition for smokeless tobacco may comprise water as a solvent.

According to one embodiment, the composition for a smokeless tobacco may have a viscosity of 15,000 5,000 cps.

According to one embodiment, the composition for smokeless tobacco comprises a flavoring agent; And at least one of a surfactant, a sweetener, and a colorant.

delete

delete

According to one embodiment, at least one of the flavoring composition, functional food composition, cosmetic composition, pharmaceutical composition, or mixture thereof may further comprise a colorant.

According to one embodiment, the smokeless cigarette can be disintegrated within 5 minutes after being placed in the mouth.

According to another aspect of the present invention, there is provided a method of manufacturing a cigarette comprising the steps of: discharging a composition for smokeless tobacco through a first nozzle in a single dose and coating the same on a packaging material to form a first region; Dispensing a flavoring composition, a functional food composition, a cosmetic composition, a pharmaceutical composition, or a mixture thereof in a single dose through a second nozzle and coating the same on the packaging material adjacent the first area to form a second area; And drying the first region and the second region. A method for manufacturing an orally dissolvable film-type smokeless cigarette is provided.

According to one embodiment, the drying step may be performed at 50 to 90 < 0 > C.

According to one embodiment, the composition for a smokeless tobacco can lower the harmfulness to a human body and improve the moldability and preference of the film-type smokeless tobacco.

According to one embodiment, the disintegration time in the oral cavity of the oral-soluble film-type smokeless tobacco can be shortened and the absorption rate of nicotine in the oral cavity can be improved.

According to one embodiment, the method of manufacturing the oral dissolution film type smokeless cigarette is simple in process and excellent in productivity.

FIG. 1 is a view showing a packing state of an orally dissolvable film type smokeless cigarette including a first region according to an embodiment.
2 is a schematic perspective view of an oral dissolution film type smokeless cigarette including a first region and a second region according to an embodiment.
FIG. 3 is a view showing a packing state of the oral soluble film type smokeless cigarette including the first region and the second region according to an embodiment.
Fig. 4 is a graph showing dissolution test results of oral-soluble film type smokeless tobacco according to the examples and the comparative examples by nicotine time scale. Fig.

The objectives, specific advantages, and novel features of the present disclosure will become more apparent from the following detailed description and examples taken in conjunction with the accompanying drawings.

Prior to that, terms and words used in the present specification and claims should not be construed in a conventional and dictionary sense, and the inventor may properly define the concept of the term in order to best explain its invention And should be construed in accordance with the meaning and concept consistent with the technical idea of the present disclosure.

In this specification, when an element such as a layer, a part, or a substrate is described as being "on", "connected", or "coupled to" another element, Connected ", or "coupled ", and may also be interposed between one or more other components. In contrast, when an element is described as being "directly on", "directly connected", or "directly coupled" to another element, no other element can be interposed between the two elements .

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the disclosure. The singular expressions include plural expressions unless the context clearly dictates otherwise.

In this specification, terms such as "comprises" or "having" are intended to specify that there are stated features, numbers, steps, operations, elements, parts or combinations thereof, and that one or more other features But do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, or combinations thereof.

In this specification, when a part is referred to as "including " an element, it is to be understood that it may include other elements as well, without departing from the other elements unless specifically stated otherwise. Also, throughout the specification, the term "on" means to be located above or below the object portion, and does not necessarily mean that the object is located on the upper side with respect to the gravitational direction.

The present disclosure is capable of various modifications and various embodiments, and specific embodiments are illustrated in the drawings and described in detail in the description. It should be understood, however, that this disclosure is not intended to be limited to any particular embodiment, but is intended to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the disclosure. In the following description of the present invention, a detailed description of known related arts will be omitted when it is determined that the gist of the present disclosure may be obscured.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description with reference to the accompanying drawings, the same or corresponding components are denoted by the same reference numerals, do.

Composition for smokeless tobacco

According to one embodiment, the composition for smokeless tobacco comprises 0.01 to 4 parts by weight of a nicotine active; 40 to 80 parts by weight of a binder; And 2 to 10 parts by weight of a plasticizer.

The composition for smokeless tobacco can reduce the harmfulness to the human body by including the nicotine active substance at a low dose and improve the preference degree of the film-type smokeless tobacco and the degree of in-buccal collapse.

The nicotine activator may be a nicotine or nicotine derivative as a main component of a composition for a smokeless tobacco, and the nicotine derivative may be a nicotine salt (tartaric acid, citric acid, etc.) or a nicotine complex. Although not limited thereto, the nicotine active may be nicotine oil which is liquid nicotine, and it may be suitable to have a purity of 99% or more. Since the composition for smokeless tobacco does not include the form of the tobacco particles, harmful components to the human body such as tar can be excluded and the harmfulness of the smokeless tobacco to the human body can be lowered.

The nicotine active may be contained in an amount of 0.01 to 4 parts by weight based on the solid content of the composition for smokeless tobacco. When the nicotine active ingredient is contained in an amount of less than 0.01 part by weight based on the solid content of the composition for smokeless tobacco, it is difficult to satisfy the requirement of a user who needs nicotine. If the nicotine active ingredient is contained in an amount exceeding 4 parts by weight, The degree of preference may be lowered, and the disintegration time in the oral cavity may be prolonged. It is possible to reduce the harmfulness to the human body by including the nicotine active substance at a low dose. In addition, the nicotine uptake rate can be relatively high compared to the high dose because of the body reaction to keep the nicotine content in the blood at a certain level or higher even if the nicotine active substance is contained at a low dose.

0.01 to 3.5 parts by weight, 0.01 to 2.5 parts by weight, 0.01 to 1.0 part by weight, 0.01 to 0.5 part by weight, 0.05 to 4 parts by weight, based on the solid content of the composition for smokeless tobacco, 0.05 to 0.5 parts by weight, 0.05 to 0.5 parts by weight, 0.1 to 4 parts by weight, 0.1 to 3.5 parts by weight, 0.1 to 2.5 parts by weight, 0.1 to 1.0 part by weight, 0.1 to 1.0 part by weight, 0.5 part by weight. The content of the nicotine active may be 0.01 to 2.5 parts by weight, more preferably 0.01 to 1.0 parts by weight, and most preferably 0.01 to 0.5 parts by weight.

The binder dissolves in the saliva in the oral cavity to release nicotine into the oral cavity and to form the nicotine active in the form of a film. The binder may be hydroxypropylmethylcellulose or hydroxypropylcellulose. Although not limited thereto, hydroxypropylmethylcellulose can be suitably used in terms of moldability, acceptability and shortening of disintegration time in oral cavity in the production of a film. Therefore, since the composition for smokeless tobacco does not include a methacrylic acid ethyl acrylate copolymer, problems of lowering of the preference degree by ethyl methacrylate and disintegration time in the oral cavity can be solved. Unlike the prior art, the smokeless cigarette can be quickly disintegrated in the oral cavity without containing an alkaline buffer.

The binder may be included in an amount of 40 to 80 parts by weight based on the solid content of the composition for a smokeless tobacco. If the binder is contained in an amount less than 40 parts by weight of the composition for smokeless tobacco, the moldability may be drastically deteriorated during production of the film. If the binder is contained in an amount exceeding 80 parts by weight, the moldability, And intraoral buckiness may be lowered. 40 to 70 parts by weight, 40 to 60 parts by weight, 40 to 50 parts by weight, 50 to 80 parts by weight, 50 to 70 parts by weight, 50 to 70 parts by weight, and 50 to 70 parts by weight, based on the solid content of the composition for smokeless tobacco, 60 to 80 parts by weight, and 60 to 70 parts by weight. The content of the binder may be in the range of 40 to 70 parts by weight, and more preferably in the range of 40 to 60 parts by weight.

The plasticizer may include at least one of the compositions for smokeless tobacco. The plasticizers include, but are not limited to, glycerin, propylene glycol. But are not limited to, ethylene glycol, polyethylene glycol, sorbitol, xylitol, maltitol, erythritol, tributhyl citrate, triethyl citrate ), Triacetin, glycerol triacetate, and the like.

The plasticizer may be contained in an amount of 2 to 10 parts by weight based on the solid content of the composition for a smokeless tobacco. If the plasticizer is contained in an amount of less than 2 parts by weight based on the solid content of the composition for a smokeless tobacco, the moldability may be deteriorated when the composition is formed into a film. If the plasticizer is contained in an amount exceeding 10 parts by weight, , Preference degree, and intraoral buckiness may be lowered. The plasticizer may be contained in an amount of 2 to 10 parts by weight, 2 to 7 parts by weight, 2 to 5 parts by weight, or 2 to 3 parts by weight based on the solid content of the composition for a smokeless tobacco. The plasticizer may be used in an amount of 2 to 7 parts by weight, preferably 2 to 5 parts by weight, although not limited thereto.

The composition for smokeless tobacco may include water as a solvent. Use of water as a solvent in place of an organic solvent such as ethanol may be suitable in terms of moldability, preference, and disintegration time in the production of a film. The water may be used in purified water, but is not limited thereto, and may be contained in an amount of 180 to 250 parts by weight based on 100 parts by weight of the solid content.

The composition for the smokeless tobacco may have a viscosity of 15,000 5,000 cps. When the viscosity of the composition for smokeless tobacco is out of the above-mentioned range, the moldability in production of the film may be deteriorated.

Wherein the composition for smokeless tobacco comprises a flavoring agent; And at least one of a surfactant, a sweetener, and a colorant. These components can improve the preference and formability of the smokeless cigarette.

The flavoring agent can improve the taste of the smokeless cigarette as a flavoring agent. But are not limited to, natural and artificial flavoring agents and include, by way of example, peppermint, spearmint, wintergreen, menthol, cinnamon, chocolate, vanillin, licorice, clove, anise, , Rose oil, vanilla, lemon oil, cacia, phenol, long, ethyl acetate, isoamyl acetate, propyl isobutylate, isobutyl butyrate, ethyl butylate, ethyl valerate, benzyl formate, , Pinene, linalool, geraniol, citronellol, citral, orange oil, coriander oil, borneol, fruit extract and the like. The flavoring agent may be included in an amount of 0.50 to 5 parts by weight based on the solid content of the composition for smokeless tobacco. In one embodiment, L-menthol, peppermint, and peppermint oil were used as flavoring agents.

The surfactant is not particularly limited as long as it can be used as an edible emulsifier. The surfactant may be selected from the group consisting of glycerin fatty acid esters, sucrose fatty acid esters, sorbit fatty acid esters, propylene glycol fatty acid esters, soybean phospholipids, calcium stearyl lactate, sorbitan oleate, sodium lauryl sulfate, Castor oil, polyoxyethylene octyl phenyl ether, and the like. The surfactant may be included in an amount of 1 to 10 parts by weight based on the solid content of the composition for a smokeless tobacco. Polysorbate 80 was used as a plasticizer in one embodiment.

The sweetener may include both natural and artificial sweetening agents. But are not limited to, sweeteners include monosaccharides, disaccharides and polysaccharides (i.e., xylose, ribose, sucrose, maltose, fructose, glucose, maltose, mannose), sucralose, Soluble sweetening agents such as aspartame, sodium saccharin, stevioside, ribaudioside, and thaumatin. The sweetener may be contained in an amount of 0.001 to 1.0 part by weight based on the solid content of the composition for a smokeless tobacco. In one embodiment, sucralose, xylitol, stevioside, and the like were used as sweeteners.

The coloring agent is not particularly limited as long as it can be used as an edible pigment. The coloring agent may include both a natural colorant and an artificial colorant. The colorant is limited to tars, and may include green 3, red 2, red 3, blue 1, blue 2, yellow 4, and yellow 5. The non-tar pigment may include ? -Carotene, water-soluble anthraquinone, copper sulfate, ferric oxide, caramel, copper and iron chlorophyllin sodium, titanium oxide and the like. The coloring agent may be included in an amount of 0.0001 to 1.0 part by weight based on the solid content of the composition for a smokeless tobacco. In one embodiment, Blue No. 1 was used as a colorant.

The composition for smokeless tobacco may further include one or more known excipients.

Oral dissolution film type smokeless tobacco

FIG. 1 is a view showing a packing state of an orally dissolvable film type smokeless cigarette including a first region according to an embodiment. 2 is a schematic perspective view of an oral dissolution film type smokeless cigarette including a first region and a second region according to an embodiment. FIG. 3 is a view showing a packing state of the oral soluble film type smokeless cigarette including the first region and the second region according to an embodiment.

As shown in FIG. 1, the cigarette 1 may be composed of an orally dissolvable film type smokeless cigarette 1 having only a first region. 0.01 to 4 parts by weight of a nicotine active substance in the first region; 40 to 80 parts by weight of a binder; 2 to 10 parts by weight of a plasticizer; A composition for smokeless tobacco, which comprises a flavoring agent, a surfactant, a coloring agent, a sweetening agent, and an excipient. Reference numeral 22 in Fig. 1 denotes a lower packaging material of the smokeless cigarette 1, 24 denotes an upper packaging material of the smokeless cigarette 1, and 26 denotes an adhesive.

As shown in Fig. 2, the cigarette may be composed of an orally dissolvable film-type smokeless cigarette 10 including both the first region 12 and the second region 14. The oral dissolution film type smokeless cigarette (10) comprises a first region (12) formed by coating the composition for smokeless tobacco in a film form; And a second region (14) formed by coating a flavoring composition, a functional food composition, a cosmetic composition, a pharmaceutical composition, or a mixture thereof in the form of a film adjacent to the first region.

That is, the orally dissolvable film-type smokeless cigarette 10 including the first region 12 and the second region 14 is a smokeless tobacco composition containing a nicotine active ingredient as a main component in the first region 12 Functional food composition, cosmetic composition, pharmaceutical composition, or mixture thereof, except for the nicotine active substance.

The preference of the smokeless cigarette can be improved by further including the second region 14 formed of the flavoring composition. The flavoring composition may include, but is not limited to, a plasticizer, a surfactant, a flavor, a coloring agent, a sweeting agent, and a diluent. The plasticizers, surfactants, flavors, colorants, sweeteners and excipients can be improved in preference and are not particularly limited as long as they are suitable for the coating process. A person skilled in the art will be able to use a known composition for the flavor composition as appropriate.

In addition, if the second region 14 formed of a functional food composition, a cosmetic composition, or a pharmaceutical composition is further included, the harmfulness of the human body due to nicotine absorption can be alleviated or eliminated. The functional food composition, cosmetic composition or pharmaceutical composition is not particularly limited as long as it is beneficial to the human body and suitable for the coating process. Conventional technologists can appropriately select and use known functional food compositions such as red ginseng for enhancing immunity, vitamins, nutritional supplements, bronchial and / or pulmonary foods having beneficial functions. Foods that are good for bronchial and / or lungs include, but are not limited to, omija, quince, wool, radish, ginseng, bellflower, old zucchini, pear, persimmon, citron and the like. Foods that are good for the bronchial and / or lung can help prevent or alleviate cough, bronchial inflammation, pneumonia, etc. due to nicotine absorption. In addition, the cosmetic or pharmaceutical composition can be used for dental whitening materials, mouthwash, mouthwash, antidote, antioxidant, anti-inflammatory, analgesic, antihistamine, topical anesthetic, antimicrobial compound, bactericide, antibiotic, .

Further, the smokeless cigarette 10 may further include one or more additional regions adjacent to the first region 12 or the second region 14. [ Thus, for example, a smokeless cigarette can be formed which is divided into a second region and a third region having different functions. According to the above configuration, only the first region of the smokeless cigarette can be ingested, or the second region and / or the third region can be ingested according to the preference.

At least one of the composition for smokeless tobacco, the flavoring composition, the functional food composition, the cosmetic composition, the pharmaceutical composition, and the mixture thereof may further comprise a coloring agent. When the colorant is included as described above, the first region 12 and the second region 14 can be distinguished, and the first region 12 and the second region 14 of the lead-free cigarette can be selectively taken. That is, only the first region 12 of the smokeless cigarette may be consumed, or the first region 12 may be consumed and the second region 14 may be partially consumed according to preference. In addition, when the colorant is included as described above, the aesthetics of the smokeless cigarette can be improved.

The smokeless cigarette may be in the form of a rectangular or elliptical film in order to place the cigarette in the mouth of the user to properly control the rate of disintegration.

The smokeless cigarette may have a surface area of 400 to 800 mm < 2 > and a thickness of 50 to 100 [mu] m, though it is not limited thereto. If the surface area and thickness of the smokeless cigarette exceed the above range, the rate of disintegration in the mouth and the rate of absorption in the oral cavity may be lowered.

The smokeless cigarette may include, but is not limited to, a moisture content of 3 to 5 parts by weight, and a pH of 7 to 9.

The smokeless cigarette can be substantially completely disintegrated within 5 minutes after it is put into the mouth. The smokeless cigarette may suitably be substantially completely disintegrated within 3 minutes after being placed in the mouth, and it may be more suitable to be substantially completely disintegrated within 2 minutes. Thus, the smokeless cigarette can be quick-acting to quickly meet the needs of a user who needs nicotine.

The smokeless cigarette is disintegrated within 5 minutes after it is put into the oral cavity, and slowly released nicotine to about 50 minutes to induce sustained release. Thus, the smokeless cigarette can satisfy both the rapid nicotine requirement reduction and the continuous nicotine requirement reduction.

As described above, the oral-soluble film-type smokeless cigarette can increase the nicotine absorption reaction and shorten the disintegration time in the oral cavity by using the composition for smokeless tobacco containing the low-dose nicotine active substance. Further, since the smokeless cigarette is of the oral dissolution film type, the oral cavity absorption rate of nicotine can be improved. The orally dissolvable film-type smokeless tobacco can be rapidly dissolved in the oral cavity to absorb substantially the same level of nicotine as the high-volume smokeless tobacco product through the capillary blood vessels of the oral mucosa. This is because, as described above, the nicotine absorption reaction can be relatively increased because of the body reaction to keep the nicotine content in the blood at a certain level or higher even if the nicotine active substance is contained in the low-dose level in the smokeless tobacco. Further, as described above, the smokeless cigarette can satisfy both of the rapid nicotine requirement reduction and the continuous nicotine requirement reduction.

Manufacture of Oral Dissolved Film Type Smokeless Tobacco

According to one embodiment, a method of manufacturing an oral dissolution film type smokeless cigarette comprises: discharging the composition for smokeless tobacco through a first nozzle in a single dose and coating the same on a packaging material to form a first region; Dispensing a flavoring composition, a functional food composition, a cosmetic composition, a pharmaceutical composition, or a mixture thereof in a single dose through a second nozzle and coating the same on the packaging material adjacent the first area to form a second area; And drying the first region and the second region.

The composition for smokeless tobacco for forming the first region can be produced, for example, by the following process.

First, the plasticizer and the surfactant are dissolved in the purified water in the first auxiliary tank.

The plasticizer and the surfactant in the first preparation tank are optionally homogenized by adding a flavoring agent, a sweetener or the like to the solution.

Next, the additional flavoring agent (L-menthol) which has been optionally dissolved in the purified water of the separate container is put into the first preparation tank and homogenized.

The main ingredient, nicotine oil, binder, and optionally further flavoring agent, is then introduced into the first formulation tank to homogenize.

The first preparation tank is depressurized to cool and degas the composition for the smokeless tobacco in the first preparation tank to remove bubbles.

Further, the flavoring composition for forming the second region can be prepared by the following process.

First, the plasticizer and the surfactant are dissolved in the purified water in the second auxiliary tank.

A flavor, a coloring agent, a sweetener and the like are optionally added to the solution in which the plasticizer and the surfactant are dissolved in the second preparation tank to homogenize the solution.

Next, the flavoring agent (L-menthol) which has been dissolved in the purified water of the separate container is put into the second preparation tank and homogenized.

The binder, and optionally further flavoring agent, is then poured into a second make-up tank to homogenize.

The second make-up tank is depressurized to cool and degas the flavoring composition in the second make-up tank to remove bubbles.

The composition for smokeless tobacco prepared above is discharged through a first nozzle in a single volume and coated on a packaging material to form a first area.

Then, the above-described flavoring composition is discharged through a second nozzle in a single dose and coated on the packaging material so as to be adjacent to the first area to form a second area.

3 is a view showing a packaging state of the oral soluble film type smokeless cigarette 10 including the first region 12 and the second region 14 according to an embodiment.

Referring to FIG. 3, the coating of the first region 12 and the second region 14 is discharged as a single volume of the product as described above, thereby eliminating the need for a separate slitting and cutting process. The coating of the first area 12 and the second area 14 is made on the upper surface of the lower package 22 and then dried and covered with the upper package 24 after the foreign object is inspected, 26), so that no separate storage step is required and productivity is improved.

The drying may be performed at 50 to 90 < 0 > C. As described above, the entire process including the drying process is performed at a temperature of less than 100 ° C, thereby reducing the process cost compared to the conventional process requiring the high-temperature melting process.

The coating of the first region 12 and the second region 14 may be performed by a device for manufacturing a multi-layer oral dissolution film disclosed in Korean Patent No. 10-1547219 of the present applicant.

Since the method of manufacturing the oral dissolution film type smokeless cigarette is coated with a predetermined size and thickness to produce the oral dissolving film type smokeless cigarette, the slitting and cutting process are unnecessary, so that the process is simple and the productivity is excellent. In addition, since the oral-soluble film-type smokeless cigarette is directly coated on the packaging material, it is not necessary to store the semifinished product separately, so that it is possible to solve the problem of storing the semifinished product. In addition, the method of manufacturing the oral dissolution film-type smokeless cigarette is formed as a single layer and formed into a single process, and does not require extrusion or high-temperature melting process, so that the number of processes is small and productivity is excellent.

Hereinafter, the present invention will be described in more detail with reference to Examples.

Practice  Yes

[ Example  1. Production of film-type smokeless tobacco according to nicotine content]

L-menthol as a flavor, blue No. 1 as a coloring agent, sucralose as a sweetening agent, sucrose as a surfactant, Zitolite, and stevia, and a diluent were added and dissolved or dispersed by stirring and homogenized using a homogenizer (PL-HMZ30DN Poong Lim Tech).

After adding hydroxypropylmethylcellulose with various amounts of nicotine oil and a binder and homogenizing it again using the same homogenizer, the gas in the film-forming liquid was removed under a vacuum condition, and a film having a width of 22 mm , A length of 28 mm and a thickness of about 91 탆. Thereafter, the film was dried at a temperature of 50 to 90 DEG C for 10 to 20 minutes to prepare a film-type smokeless tobacco containing nicotine.

The preference and the haze of the film-type smokeless cigarette thus prepared were examined. Table 1 shows preference and disintegration time according to the nicotine content of each of Example 1 and Comparative Example 1. < tb >< TABLE > Comparative Example 1-1 was used as a nicotine content of 25mg of GlaxoSmithKline smoking aids product you kwitin ^®.

[ Example  2. Production of film-type smokeless cigarette according to binder type]

A plasticizer, a surfactant, a flavor, a coloring agent, a sweeting agent, and a diluent were added to purified water in the same manner as in Example 1, And homogenized using a homogenizer (PL-HMZ30DN Poong Lim Tech).

Nicotine oil and various kinds of binders were added thereto and then homogenized using the same homogenizer. Then, the gas in the film production liquid was removed under a vacuum condition, and a size of 22 mm in width and 28 mm in width on the pouch Lt; RTI ID = 0.0 > 91 < / RTI > Thereafter, the film was dried at a temperature of 50 to 90 DEG C for 10 to 20 minutes to prepare a film-type smokeless tobacco containing nicotine.

The formability, preference and haze of the film-type smokeless tobacco prepared as described above were examined. Table 2 shows the moldability, preference and disintegration time according to the kind of binder in each of Example 2 and Comparative Example 2.

[ Example  3. Production of film-type smokeless tobacco according to binder content]

A plasticizer, a surfactant, a flavor, a coloring agent, a sweeting agent, and a diluent were added to purified water in the same manner as in Example 1, And homogenized using a homogenizer (PL-HMZ30DN Poong Lim Tech).

Then, hydroxypropylmethylcellulose was added thereto at various weight ratios (w / w) using a nicotine oil and a binder, homogenized again using the same homogenizer, the gas in the film-forming solution was removed under vacuum conditions, Coated on the pouch to have a size of 22 mm in width and 28 mm in length and a thickness of about 91 탆. Thereafter, the film was dried at a temperature of 50 to 90 DEG C for 10 to 20 minutes to prepare a film-type smokeless tobacco containing nicotine.

The formability, preference and haze of the film-type smokeless tobacco prepared as described above were examined. Table 3 shows the moldability, preference and disintegration time according to the components and contents of each of Example 3 and Comparative Example 3.

[ Example  4. Nicotine-containing films and Flavoring agent  Production of parallel coated film-type smokeless cigarette containing film

Article 1 Preparation of Tank-Lead-Free Smokeless Tobacco Composition

A plasticizer, a surfactant, a sweeting agent and a diluent were added to purified water in the same manner as in Example 1, followed by stirring or dissolving or dispersing the mixture. The mixture was homogenized (PL-HMZ30DN Poong Lim Tech).

To this was added hydroxypropyl methylcellulose in a weight ratio (w / w) as a nicotine oil and binder, and homogenized again using the same homogenizer.

Article 2 Tanks - Flavoring agent  And colorant-containing composition

A plasticizer, a surfactant, a flavor, a coloring agent, a sweeting agent, and a diluent were added to purified water in the same manner as in Example 1, And homogenized using a homogenizer (PL-HMZ30DN Poong Lim Tech). Hydroxypropylmethylcellulose was added thereto as a binder in a weight ratio (w / w) and homogenized again using the same homogenizer.

Each composition was vacuum degassed to remove the gas in the film preparation liquid and if the single dose of nicotine oil was 0.5 mg, the first and second regions were 22 mm wide by 14 mm wide and about 91 mm thick, respectively And coated in parallel on the pouch with a casting machine. Thereafter, the film was dried at a temperature of 50 to 90 DEG C for 10 to 20 minutes to prepare a film-type smokeless tobacco containing nicotine.

The formability, preference and haze of the film-type smokeless tobacco prepared as described above were examined. Table 4 shows moldability, preference and disintegration time according to the components and contents of each of Examples 4-1 to 4-3 and Comparative Example 4-1.

[ Example  5. Nicotine-containing film, and The flavoring agent  Production of parallel coated film-type smokeless tobacco containing a functional food composition-containing film]

Article 1 Preparation of Tank-Lead-Free Smokeless Tobacco Composition

A plasticizer, a surfactant, a sweeting agent and a diluent were added to purified water in the same manner as in Example 1, followed by stirring or dissolving or dispersing the mixture. The mixture was homogenized (PL-HMZ30DN Poong Lim Tech).

To this was added hydroxypropyl methylcellulose in a weight ratio (w / w) as a nicotine oil and binder, and homogenized again using the same homogenizer.

Article 2 Tanks - Flavoring agent , Colorant and functional food composition

A plasticizer, a surfactant, a flavor, a coloring agent, a sweeting agent, and a diluent were added to purified water in the same manner as in Example 1, And homogenized using a homogenizer (PL-HMZ30DN Poong Lim Tech). To this was added hydroxypropylmethylcellulose at a weight ratio (w / w) as a functional food composition and binder and homogenized again using the same homogenizer. The functional food composition may be a bellflower extract (60 brix in terms of solid content) or a vitamin B-rich red ginseng extract (60 brix in terms of solid content) having immunity, anticancer and anti- Respectively.

Each composition was vacuum degassed to remove the gas in the film preparation liquid and if the single dose of nicotine oil was 0.5 mg, the first and second regions were 22 mm wide by 14 mm wide and about 91 mm thick, respectively And coated in parallel on the pouch with a casting machine. Thereafter, the film was dried at a temperature of 50 to 90 DEG C for 10 to 20 minutes to prepare a film-type smokeless tobacco containing nicotine.

The formability, preference and haze of the film-type smokeless tobacco prepared as described above were examined. Table 5 shows moldability, preference degree and disintegration time according to the components and contents of each Example 5.

[ Example  6. Effect of nicotine content on film-type smokeless tobacco Disintegration  And nicotine dissolution rate]

(Film-type smokeless tobacco containing 0.5 mg of nicotine), Example 3-8 (film-type smokeless tobacco containing 0.3 mg of nicotine) and Comparative Example 1-1 (2.5 mg of nicholine as a product of GSK) Table 6, Table 7 and FIG. 4 show the comparative results of the disintegration and nicotine dissolution of Example 4-3 (nicotine 0.5 mg + parallel coating film-type smokeless tobacco of the flavoring film). The disintegration test was performed using a disintegration tester manufactured by INTERNATIONAL ENGINEERING CO., LTD. And the results are shown in Table 6. Table 7 and Fig. 4 show the results of the elution test of nicotine by time in the condition of pH 6.8.

From the above description, it will be understood by those skilled in the art that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. In this regard, it should be understood that the above-described embodiments are to be considered in all respects as illustrative and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention without departing from the scope of the present invention as defined by the appended claims.

Explanation of symbols

1, 10: Smokeless cigarette 12: First area

14: second region 22: bottom packaging material

24: upper packing material 26: adhesive

Claims (13)

0.01-2.5 parts by weight of liquid nicotine having a purity of 99% or more;
40 to 60 parts by weight of hydroxypropylmethylcellulose or hydroxypropylcellulose; And
2 to 5 parts by weight of a plasticizer; and a first region formed by coating a composition for a smokeless tobacco in the form of a film,
A smokeless cigarette, further comprising a second region formed by coating a flavoring composition, a functional food composition, a cosmetic composition, a pharmaceutical composition or a mixture thereof in film form adjacent to the first region.
delete delete delete The method according to claim 1,
Wherein the composition for smokeless tobacco comprises water as a solvent.
The method according to claim 1,
The composition for smokeless tobacco has a viscosity of 15,000 ± 5,000 cps.
The method according to claim 1,
The composition for smokeless tobacco includes
Flavoring agents; And
At least one of a surfactant, a sweetener, and a colorant.
delete delete The method according to claim 1,
Wherein the at least one of the composition for smokeless tobacco, the flavoring composition, the functional food composition, the cosmetic composition, the pharmaceutical composition, and the mixture thereof further comprises a coloring agent.
The smokeless tobacco according to claim 1, which disintegrates within 5 minutes after being put into the mouth.
Forming a first region by discharging a composition for smokeless tobacco according to claim 1 through a first nozzle in a single dose and coating the same on a packaging material;
Dispensing a flavoring composition, a functional food composition, a cosmetic composition, a pharmaceutical composition, or a mixture thereof in a single dose through a second nozzle and coating the same on the packaging material horizontally adjacent to the first area to form a second area; And
And drying the first region and the second region.
[14] The method of claim 12, wherein the drying step is performed at 50 to 90 [deg.] C.

Images