US20160283696A1 - Methods and device arrangement for physical activity thresholds promoting fat and cholesterol metabolism in high risk subjects - Google Patents

Methods and device arrangement for physical activity thresholds promoting fat and cholesterol metabolism in high risk subjects Download PDF

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Publication number
US20160283696A1
US20160283696A1 US15/034,185 US201415034185A US2016283696A1 US 20160283696 A1 US20160283696 A1 US 20160283696A1 US 201415034185 A US201415034185 A US 201415034185A US 2016283696 A1 US2016283696 A1 US 2016283696A1
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acceleration
physical activity
maxima
person
cholesterol
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Inventor
Juhani Leppäluoto
Karl-Heinz Herzig
Riikka Ahola
Timo Jämsä
Jari Jokelainen
Sirkka Keinänen-Kiukaanniemi
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Gleap Health Technologies Oy
SARTORIO OY
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Assigned to GLEAP HEALTH TECHNOLOGIES OY reassignment GLEAP HEALTH TECHNOLOGIES OY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SARTORIO OY
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • G06F19/3481—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1118—Determining activity level
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4866—Evaluating metabolism
    • A—HUMAN NECESSITIES
    • A63—SPORTS; GAMES; AMUSEMENTS
    • A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
    • A63B69/00—Training appliances or apparatus for special sports
    • A63B69/0028—Training appliances or apparatus for special sports for running, jogging or speed-walking
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
    • G01P15/00—Measuring acceleration; Measuring deceleration; Measuring shock, i.e. sudden change of acceleration

Definitions

  • the invention relates to method and device for determining physical activity thresholds to improving sugar, cholesterol and fat metabolism in subjects who have sedentary life style.
  • the use of motion sensors and transduction units to measure physical activity intensity and volume have been presented in U.S.2008/0312560A1, WO02005117703.
  • a method in which physical activity improving cholesterol metabolism in healthy subjects is presented in U.S. 2010/0137107 A1.
  • the invention described here belongs to the medical discipline and includes the determination of physical activity thresholds that can be used for preventing risks for metabolic diseases such as diabetes and cardiovascular disease by reducing blood cholesterol, triglycerides and visceral fat mass.
  • the earlier invention purposed for healthy subjects related to physical activity reducing blood cholesterol (U.S. 2010/0137107 A1) is not suitable to subjects who have risks of diabetes and/or cardiovascular diseases, as they are not capable to perform prescribed physical activity previously shown to reduce blood cholesterol in healthy subjects (Herzig et al. 2014 Int J Obesity38:1089).
  • Calcification of blood vessels, high blood sugar, cholesterol and triglycerides are risk factors for diabetes and cardiovascular diseases. These risk factors can be reduced by increased physical activity and weight reduction programs. Increased exercise will lead to decreases in blood LDL-cholesterol and increases HDL-cholesterol (tannescu et a. 2002 JAMA, 288,4994, Kraus et al. 2002, NEJM 347, 1483) all reducing risks of cardiovascular diseases. In a similar way increased weekly exercise and weight reduction programs prevented developing of the type 2 diabetes in 60% of patients (Tuomilehto et al. 2002,NEJM 304.1343, Knowler et al. 2002, NEJM 346:393).
  • Fat tissues especially those around the internal organs are body's energy sources and are released to blood circulation during exercises. It has been shown that during exercises fat from the internal organs is first mobilized and starts the reduction of body weight (O'Leary et al. 2009, J Appl Physiol 100,1958).
  • the invention described here manages physical activity thresholds reducing blood cholesterol, triglycerides and visceral fat in overweight subjects with metabolic disorders. These subjects are not able to reach physical activity thresholds presented in the patent (U.S. 20107137107), and therefore they need their own physical activity thresholds.
  • the patents U.S. 2008/0312560 A1 and U.S. 2010/137107 A1 and the one described here belong to the same patents family, in which determining of physical activity thresholds are novel and differ from the previously known techniques
  • Accelerometers (patents U.S. 2010191155 A1, EP 0700661 A2, U.S. 2009171614 A1, EP 2210557 A1 and U.S. 2001049470 A1) and a heart rate monitor (U.S. 20110213) have been previously used for measuring energy expenditure of physical activity or following body weight and nutrient intake in healthy subjects and heart rate monitor for protein consumption and recovery in athletes. It should be noted that all the above mentioned methods measuring energy expenditure are useless for establishing threshold levels improving health. For instance in a previous study we demonstrated that walking 12982 daily steps at the acceleration range 0.3-1.0 g had no effect on blood cholesterol, whereas 1062 daily steps at the acceleration range 1.1-2.4 g reduced blood cholesterol by 15% (Vainionischen et al.
  • Our invention has many advantages. It makes it possible to determine for the first time the volume and intensity of the physical activity threshold reducing disease risks in subjects, who are sedentary, have overweight and suffer from metabolic disorders. These subjects cover approximately 50% of the population and previously there have not been any physical activity recommendations for them.
  • the accelerometer described in the intervention can be easily used continuously making it possible to register all types of physical activity including habitual activities. This will make it easy to meet our novel physical activity recommendations. From the point of preventive medicine walking is also the best form of physical activity. It activates the biggest muscles in the body and its energy expenditure can be accurately measured by accelerometers recording number of steps and step induced accelerations or walking speeds. Maintaining walking ability protects also from falling accidents and hospitalization.
  • the results presented in FIG. 1A and 1B are derived from 68 subjects carrying accelerometer for 3 months.
  • the subjects were overweight men and women aged 30-70 years and had abnormal blood sugar.
  • One half of the subjects participated in supervised exercise weekly and the other half continued their normal life style.
  • the subjects carried accelerometers during wake-full time on their waist.
  • the acceleration values their daily numbers were continuously registered.
  • Blood samples were taken at the beginning and end of the trial to measure blood sugar, insulin, cholesterol, LDL-cholesterol and triglycerides.
  • the amount of the visceral fat was measured by a bio-impedance method.
  • the distribution of the accelerations during 3 months showed that exercises increased significantly number of steps or impacts in the acceleration classes 0.3-0.7 g, corresponding typically to slow walking 2-3 km/h.
  • the steps in the acceleration class 0.3-0.7 were divided by their magnitudes to quartiles. Cholesterol and fat concentrations between each quartile were analyzed. The results showed ( FIG. 1A and 1B ) that total cholesterol, LDL-cholesterol, triglycerides, and visceral fat in the fourth quartile (over 6520 daily steps) were significantly lower than in the other quartiles. 6520 daily steps is the threshold for physical activity, the exceeding of which reduced total cholesterol by 0.6 mmol/l, LDL-cholesterol 0.7 mmol/l, triglycerides 0.4 mmol/l and the area of visceral fat by 12%.
  • the invention described herein does essentially differ from the previously known methods by which exercises have been used for prevention of risk factors of diabetes and cardiovascular diseases. Physicians have generally been aware about the beneficial effects of regular exercise, but the volume, intensity and duration of the exercises have been unknown. It was novel and unexpected in our invention that in sedentary subjects physical activity of very low intensity (accelerations 0.3-0.7 g) reduced concentrations of the major risk factors of diabetes and cardiovascular diseases. Our invention is also different form other patents and recommendations, since those do not take low intensity exercise into account.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Artificial Intelligence (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Signal Processing (AREA)
  • Epidemiology (AREA)
  • Fuzzy Systems (AREA)
  • Mathematical Physics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Primary Health Care (AREA)
  • Evolutionary Computation (AREA)
  • Obesity (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US15/034,185 2013-11-04 2014-10-31 Methods and device arrangement for physical activity thresholds promoting fat and cholesterol metabolism in high risk subjects Abandoned US20160283696A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20130323 2013-11-04
FI20130323A FI20130323A (sv) 2013-11-04 2013-11-04 Förfarande för mätning av ett tröskelvärde för motion som främjar fett- och kolesterolmetabolism och minskar mängden fettvävnad hos personer med övervikt eller förhöjd risk för hjärtsjukdom och diabetes
PCT/FI2014/000031 WO2015063366A1 (en) 2013-11-04 2014-10-31 Methods and device arrangement for physical activity thresholds promoting fat and cholesterol metabolism in high risk subjects

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US16/438,506 Continuation-In-Part US20190290191A1 (en) 2013-11-04 2019-06-12 Low impact physical activities for reducing risk of cholesterol and fat metabolism disorders in overweight people

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EP (1) EP3065639A4 (sv)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019043292A1 (en) * 2017-08-29 2019-03-07 Gleap Health Technologies Oy METHODS AND ARRANGEMENT OF THRESHOLD DEVICE OF PHYSICAL ACTIVITY REDUCING THE RISKS OF DIABETES, CARDIOVASCULAR DISEASES, INFLAMMATIONS, DEMENTIA, CANCERS AND MORTALITY IN SEDENTARY SUBJECTS
WO2020111787A1 (en) * 2018-11-29 2020-06-04 Samsung Electronics Co., Ltd. Method for providing recommendations for maintaining a healthy lifestyle basing on daily activity parameters of user, automatically tracked in real time, and corresponding system

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CN115191961B (zh) * 2021-04-09 2024-08-23 广东小天才科技有限公司 心肺健康检测方法及装置、可穿戴设备、存储介质

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JP4826191B2 (ja) * 2005-09-27 2011-11-30 パナソニック電工株式会社 活動量計
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Publication number Priority date Publication date Assignee Title
WO2019043292A1 (en) * 2017-08-29 2019-03-07 Gleap Health Technologies Oy METHODS AND ARRANGEMENT OF THRESHOLD DEVICE OF PHYSICAL ACTIVITY REDUCING THE RISKS OF DIABETES, CARDIOVASCULAR DISEASES, INFLAMMATIONS, DEMENTIA, CANCERS AND MORTALITY IN SEDENTARY SUBJECTS
JP2020531236A (ja) * 2017-08-29 2020-11-05 グリープ ヘルス テクノロジーズ オーイー 座りがちな対象の糖尿病、心血管疾患、炎症、認知症、がん、及び死亡率のリスクを軽減する身体活動の閾値に関する方法及び装置の手配
JP7336061B2 (ja) 2017-08-29 2023-08-31 グリープ ヘルス テクノロジーズ オーイー 座りがちな対象の糖尿病、心血管疾患、炎症、認知症、がん、及び死亡率のリスクを軽減する身体活動の閾値に関する方法及び装置の手配
US11804290B2 (en) 2017-08-29 2023-10-31 Gleap Health Technologies Oy Methods and device arrangement for physical activity thresholds reducing risks of diabetes, cardiovascular diseases, inflammations, dementia, cancers and mortality in sedentary subjects
WO2020111787A1 (en) * 2018-11-29 2020-06-04 Samsung Electronics Co., Ltd. Method for providing recommendations for maintaining a healthy lifestyle basing on daily activity parameters of user, automatically tracked in real time, and corresponding system

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FI20130323A (sv) 2015-05-05
JP2016535657A (ja) 2016-11-17
EP3065639A1 (en) 2016-09-14
JP6777543B2 (ja) 2020-10-28
WO2015063366A8 (en) 2015-09-24
WO2015063366A1 (en) 2015-05-07
CN106255458A (zh) 2016-12-21
EP3065639A4 (en) 2017-08-02

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