US20160220472A1 - Oral compositions - Google Patents

Oral compositions Download PDF

Info

Publication number
US20160220472A1
US20160220472A1 US14/917,442 US201414917442A US2016220472A1 US 20160220472 A1 US20160220472 A1 US 20160220472A1 US 201414917442 A US201414917442 A US 201414917442A US 2016220472 A1 US2016220472 A1 US 2016220472A1
Authority
US
United States
Prior art keywords
oral composition
agents
fluoride
oral
copolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/917,442
Other languages
English (en)
Inventor
Yizhong Wang
Joel D. Oxman
Tiffany Ton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Priority to US14/917,442 priority Critical patent/US20160220472A1/en
Publication of US20160220472A1 publication Critical patent/US20160220472A1/en
Assigned to 3M INNOVATIVE PROPERTIES COMPANY reassignment 3M INNOVATIVE PROPERTIES COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: OXMAN, JOEL D., TON, TIFFANY T., WANG, YIZHONG
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Definitions

  • the present disclosure generally relates to oral compositions, e.g. oral compositions with acid buffering or neutralizing capacity.
  • the erosion of dental enamel can lead to pain, discoloration, mechanical failure, and greater susceptibility to dental carries.
  • Chemical erosion of dental enamel may arise from the presence of acid in the oral cavity.
  • One of the many purposes that oral compositions may serve is to help control pH in the oral cavity.
  • the present disclosure generally relates to oral compositions, e.g. oral compositions with acid buffering or neutralization capacity.
  • the oral composition of the present disclosure has the capability to buffer or neutralizing acid in oral cavity.
  • the oral composition of the present disclosure can form a film in less than about 30 seconds after the oral composition is contacted with water or dried with a stream of compressed air. As a result, the oral composition of the present disclosure can provide a barrier to protect dental tissues.
  • the oral composition can include a solvent comprising water and a cosolvent chosen from lower alkyl alcohols and acetone; a basic copolymer comprising basic acrylate monomeric units, basic methacrylate monomeric units, or a combination thereof; no less than 0.5 wt-% of an acid buffering or neutralizing agent; and optionally an active agent.
  • the oral composition can include from about 6 to about 15 wt-% of water, from about 30 to about 80 wt-% of the cosolvent, and from about 25 to about 55 wt-% of the basic copolymer.
  • the basic copolymer can be dissolved in the oral composition, the oral composition is capable of forming a film on a surface when contacted with an aqueous solution; and the wt-% of each component is based on the total weight of the composition.
  • the present disclosure generally relates to oral compositions.
  • the oral compositions of the present disclosure can be used to neutralize acids in the oral cavity.
  • dental structures include, but are not limited to, dental tissues and dental articles.
  • dental tissues include, but are not limited to hard and soft dental tissues.
  • Hard and soft oral tissues include, but not limited to, teeth, dental arch, and the surrounding tissues and support structures including gingiva and hard palate.
  • dental articles include, but are not limited to an article that can be attached (e.g., bonded) to an oral surface (e.g., a tooth structure).
  • dental articles include, but are not limited to, replacements, inlays, onlays, veneers, full and partial crowns, bridges, implants, implant abutments, copings, dentures, posts, bridge frameworks and other bridge structures, abutments, orthodontic appliances and devices including, but not limited to archwires, buccal tubes, brackets and bands, and prostheses (e.g., partial or full dentures).
  • an aqueous solution includes, but is not limited to water, saliva, artificial saliva or combinations thereof.
  • an oral composition can include a solvent, a basic copolymer, an acid buffering or neutralizing agent and optionally an active agent.
  • the solvent can have water and a cosolvent.
  • the cosolvent can be chosen from lower alkyl alcohols and acetone.
  • the basic copolymer can have basic acrylate monomeric units, basic methacrylate monomeric units, or a combination thereof.
  • the oral composition can comprise no less than 0.5 wt-% of an acid buffering or neutralizing agent.
  • the oral composition can comprise from about 6 to about 15 wt-% of water, from about 30 to about 80 wt-% of the cosolvent, and from about 25 to about 55 wt-% of the basic copolymer;
  • the basic copolymer can be dissolved in the oral composition.
  • the oral composition is capable of forming a film on a surface when contacted with an aqueous solution and the wt-% of each component is based on the total weight of the composition.
  • the oral composition of the present disclosure can be used to provide coatings that seal open dentin tubules and/or enamel cracks to minimize tooth sensitivity.
  • the oral composition can comprise from about 8 to about 12 wt-% of the water.
  • the lower alkyl alcohols can include low carbon number (e.g. C 1 -C 5 ) alcohols.
  • low carbon number e.g. C 1 -C 5
  • examples of lower alkyl alcohols as used herein include, but are not limited to, ethanol, isopropanol, propylene glycol, glycerin and low molecular weight polyethylene glycol and ethylene glycol based ester alcohols.
  • the cosolvent can be ethanol. In other embodiments, the oral composition can comprise from about 35 to 60 wt-% of the cosolvent.
  • the solvent can further include at least one additional component chosen from isopropanol, propylene glycol, glycerin, low molecular weight polyethylene glycol, ethylene glycol based ester alcohols, and combinations thereof.
  • the solvent can include water, ethanol and glycerin.
  • the basic copolymer for example, can be used as film formers.
  • the film can, for example, provide a barrier to protect the dental tissues, provide an anchoring structure to the dental tissues, and promote such tissues to enhance uptake active agents.
  • the basic coating also worked as an acid buffer or acid neutralizing composition, since it can react with acid to prevent tooth acid erosion.
  • the basic copolymer can include a copolymer containing dimethylaminoethyl methacrylate. In some other embodiments, the basic copolymer can include a copolymer based on dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate. In other embodiments, the basic copolymer can be chosen from Eudragit E100 and other copolymer containing dimethylaminoethyl methacrylate for ionic crosslinking.
  • the molecular weight of the basic copolymer can be from about 10,000 to about 100,000.
  • the oral composition of the present disclosure can further include a neutral copolymer having neutral acrylate monomeric units, neutral methacrylate monomeric units, or a combination thereof.
  • the neutral copolymer can include copolymers of ethyl acrylate, methyl methacrylate and methacrylic acid ester with quaternary ammonium groups.
  • the neutral copolymer can include Eudragit RS 100 (marketed by Evonic Industries AG, Damstadt, Germany), Eudragit RL 100 (marketed by Evonic Industries AG, Damstadt, Germany), and combinations thereof.
  • the oral composition can comprise from about 0 to about 40 wt-% of the neutral copolymer.
  • Neutral copolymers can be used as film formers with a flexible property and a low strength that maintain adhesion during scratching or toothbrushing.
  • the flexible neutral copolymers can help to form a tougher film and thus provide a good adhesion to dental tissues.
  • the consistency of the oral composition of the present disclosure can be from about 45 to about 110.
  • the viscosities of the oral composition are characterized with consistency. The higher the consistency of the composition represents the easier spreading of the composition when pressure is applied, which means lower viscosity.
  • the oral composition has certain consistency range to be applied in an oral cavity. When the consistency of the oral composition is too high, the oral composition is too runny and produces a dropping problem. When the consistency of the oral composition is too low, the oral composition is too viscous and is difficult to spread.
  • the water miscible solvents can diffuse into water and water can also diffuse into the oral composition.
  • the molecular interaction among the copolymer chains can increase dramatically and then form a durable, toothbrush abrasion resistant and slippery film.
  • the film can be formed by air drying. For example, air blowing can evaporate water and co-solvents to form the durable, brush abrasion resistant and slippery film.
  • the oral composition of the present disclosure can form the film in less than about 30 seconds after the oral composition is contacted with water or dried with a stream of compressed air.
  • the oral composition of the present disclosure can provide prolonged coating/film.
  • the film remains on at least 90% of the surface after brushing the surface for at least 5 strokes. In some other embodiments, the film remains on at least 90% of the surface after brushing the surface for at least 10 strokes. In other embodiments, the film remains on at least 90% of the surface after brushing the surface for at least 20 strokes. In yet other embodiments, the film remains on at least 90% of the surface after brushing the surface for at least 30 strokes. In some cases, the film remains on at least 90% of the surface after brushing the surface for at least 60 strokes. In other cases, the film remains on at least 90% of the surface after brushing the surface for at least 90 strokes. In yet other cases, the film remains on at least 90% of the surface after brushing the surface for at least 120 strokes.
  • the film remains on at least 90% of the surface after brushing the surface for from 5 to 120 strokes. In some other embodiments, the film remains on at least 90% of the surface after brushing the surface for from 10 to 90 strokes. In other embodiments, the film remains on at least 90% of the surface after brushing the surface for from 20 to 60 strokes. In yet other embodiments, the film remains on at least 90% of the surface after brushing the surface for from 5 to 120 strokes.
  • the oral composition can be suitable for administration to the oral cavity of a patient.
  • the oral composition can be applied from the composition's container or dispenser such as a bottle, syringe, or tube.
  • a dental brush, microfiber, foam or sponge applicator or cotton Q tip is used to rub the surface of the dental structure and leave a thin layer of coating on the surface.
  • a tray applicator, a dental tray, or a dental strip filled with the oral composition can be used.
  • the oral composition can cover the surface of the dental structure and leave a layer of coating on the surface.
  • the oral composition can be sprayed (e.g. air-brushing) with a spray device or aerosol applicator onto the surface of the dental structure.
  • the oral composition can be directly painted onto the surface of the dental structure with a brush tip attached to a syringe. In yet other embodiments, the oral composition can be applied as a rinse. The oral composition can be set into a coating on the dental structure and its attachments within 30 seconds by water, saliva, or dried by air blowing.
  • the oral composition of the present disclosure has the capability to buffer or neutralize acid in oral cavity to reduce acid erosion.
  • the acid buffering or neutralizing agent of the present disclosure can include any anti-acid compounds suitable for use in the present disclosure.
  • the acid buffering agent can include any basic substance which dissociates in water (i.e., an aqueous base) to produce one or more hydroxyl ions, or any substance which has can accept proton, or which has an unshared pair of electrons.
  • the acid buffering or neutralizing agent can include carbonates, bicarbonates, chlorides, hydroxides, dibasic citrates phosphates, sulfates and the like, typically in the form of a salt.
  • exemplary salts include a complex with sodium, potassium, calcium, ammonium, aluminum, magnesium, and the like.
  • the acid buffering agent can include sodium carbonate, potassium carbonate, calcium carbonate, ammonium bicarbonate, ammonium carbonate, ammonium chloride, ammonium hydroxide, dibasic ammonium citrate, ammonium phosphate (rnonobasic or dibasic) , ammonium sulfate, aluminum carbonate, aluminum hydroxide, calcium citrate, calcium hydroxide, magnesium carbonate, magnesium hydroxide, magnesium phosphate (dibasic) , potassium hydroxide, potassium bicarbonate, and the like.
  • the acid buffering or neutralizing agent can include phosphate based buffers which contain PO 4 3 ⁇ anion (e.g., sodium phosphate, potassium phosphate, calcium phosphate and ammonium phosphate), hydrogen phosphate based buffers which contain HPO 4 2 ⁇ anion (e.g., sodium hydrogen phosphate, potassium phosphate and calcium phosphate), dihydrogen phosphaste based buffers which contain H 2 PO 4 ⁇ anoin (e.g., sodium dihydrogen phosphate, potassium dihydrogen phosphate and calcium dihydrogen phosphate), carboxylates based buffers which contain RCOO ⁇ anion (e.g., sodium acetate, sodium citrate, potassium acetate, ammonium acetate and ammonium citrate), carbonate based buffers which contain CO 3 2 anion (e.g., sodium carbonate, calcium carbonate, magnesium carbonate, iron carbonate, potassium carbonate and ammonium carbonate), hydrogen carbonate buffers which contain HCO 3
  • the oral composition of the present disclosure can release active agents to strengthen the dental tissues and reduce sensitivity.
  • the oral composition of the present disclosure can include active agents.
  • the active agents can include, but are not limited to whitening agents, anticaries agents, fluoride-delivery agents, anti-gingivitis agents, tartar control agents, antiplaque agents, periodontal actives, breath freshening agents, malodor control agents, tooth desensitizers, salivary stimulants, flavors, biofilm disruptors, antimicrobials, anesthetic agent, pain killers, stain removal agents, coloring agents, remineralization agents, calculus-softening agents, and combinations thereof.
  • the oral compositions of the present disclosure can include a whitening agent.
  • a “whitening agent” is a material which is effective to effect whitening of a tooth surface to which it is applied.
  • the oral compositions of the present disclosure can include a peroxide whitening agent, comprising a peroxide compound.
  • a “peroxide compound” is an oxidizing compound comprising a bivalent oxygen-oxygen group.
  • Peroxide compounds can include, but are not limited to, peroxides and hydroperoxides, such as hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, pharmaceutically-acceptable salts thereof, and mixtures thereof.
  • Peroxides of alkali and, alkaline earth metals can include, but are not limited to, lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof.
  • Organic peroxy compounds can include, but are not limited to, carbamide peroxide (also known as urea hydrogen peroxide), glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, and monoperoxyphthalate, and mixtures thereof.
  • Peroxy acids and their salts can include, but are not limited to, organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as persulfate, dipersulfate, percarbonate, perphosphate, perborate and persilicate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof.
  • the peroxide compound can include, but are not limited to, hydrogen peroxide, urea peroxide, sodium percarbonate and mixtures thereof.
  • the peroxide compounds can include hydrogen peroxide.
  • the peroxide compound can consist essentially of hydrogen peroxide.
  • the oral compositions of the present disclosure can include a non-peroxide whitening agent.
  • Whitening agents among those useful herein can include non-peroxy compounds, such as chlorine dioxide, chlorites and hypochlorites.
  • Chlorites and hypochlorites can include, but are not limited to, those of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium.
  • Non-peroxide whitening agents can also include, but are not limited to, colorants, such as titanium dioxide and hydroxyapatite.
  • compositions of the present disclosure can include a tartar control (anticalculus) agent.
  • Tartar control agents among those useful herein can include, but are not limited to, phosphates and polyphosphates (for example pyrophosphates), polyaminopropanesulfonic acid (AMPS), polyolefin sulfonates, polyolefin phosphates, diphosphonates such as azacycloalkane-2,2-diphosphonates (e.g., azacycloheptane-2,2-diphosphonic acid), N-methyl azacyclopentane-2,3-diphosphonic acid, ethane-1-hydroxy-1,1-diphosphonic acid (EHDP) and ethane-1-amino-1,1-diphosphonate, phosphonoalkane carboxylic acids and salts of any of these agents, for example their alkali metal and ammonium salts.
  • phosphates and polyphosphates for example pyrophosphate
  • Useful inorganic phosphate and polyphosphate salts can include, but are not limited to, monobasic, dibasic and tribasic sodium phosphates, sodium tripolyphosphate, tetrapolyphosphate, mono-, di-, tri- and tetrasodium pyrophosphates, sodium trimetaphosphate, sodium hexametaphosphate and mixtures thereof, wherein sodium can optionally be replaced by potassium or ammonium.
  • Other useful anticalculus agents can include, but are not limited to, polycarboxylate polymers and polyvinyl methyl ether/maleic anhydride (PVME/MA) copolymers, such as those available under the Gantrez® from ISP, Wayne, N.J.
  • the oral compositions of the present disclosure can include a stannous ion source useful, for example, as a periodontal active, tartar control agent, anticaries agent or tooth desensitizer.
  • a stannous ion source useful, for example, as a periodontal active, tartar control agent, anticaries agent or tooth desensitizer.
  • Any orally acceptable stannous ion source can be used, including, but not limited to, stannous fluoride, other stannous halides such as stannous chloride dehydrate, organic stannous carboxylate salts such as stannous formate, acetate, gluconate, lactate, tartrate, oxalate, malonate and citrate, stannous ethylene glyoxide and the like.
  • the oral compositions of the present disclosure can include an antimicrobial (e.g., antibacterial) agent.
  • an antimicrobial agent e.g., antibacterial
  • Any orally acceptable antimicrobial agent can be used, including, but not limited to, Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol); 8-hydroxyquinoline and salts thereof; zinc and stannous ion sources such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate; copper (II) compounds such as copper (II) chloride, fluoride, sulfate and hydroxide; phthalic acid and salts thereof such as magnesium monopotassium phthalate; sanguinarine; quaternary ammonium compounds, such as alkylpyridinium chlorides (e.g., cetylpyridinium chloride (CPC), combinations of CPC with zinc and/or enzymes, tetradecylpyridinium chloride
  • the oral compositions of the present disclosure can include an antioxidant.
  • Any orally acceptable antioxidant can be used, including, but not limited to, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and mixtures thereof.
  • the oral compositions of the present disclosure can include a saliva stimulating agent, useful for example in amelioration of dry mouth.
  • a saliva stimulating agent useful for example in amelioration of dry mouth.
  • Any orally acceptable saliva stimulating agent can be used, including without limitation food acids such as citric, lactic, malic, succinic, ascorbic, adipic, fumaric, and tartaric acids, and mixtures thereof.
  • compositions of the present disclosure can include a breath freshening agent.
  • breath freshening agent Any orally acceptable breath freshening agent can be used, including without limitation zinc salts such as zinc gluconate, zinc citrate and zinc chlorite, alpha-ionone and mixtures thereof
  • the oral compositions of the present disclosure can include an antiplaque (e.g., plaque disrupting) agent.
  • an antiplaque agent e.g., plaque disrupting
  • Any orally acceptable antiplaque agent can be used, including without limitation stannous, copper, magnesium and strontium salts, dimethicone copolyols such as cetyl dimethicone copolyol, papain, glucoamylase, glucose oxidase, urea, calcium lactate, calcium glycerophosphate, strontium polyacrylates and mixtures thereof in some embodiments, the antiplaque agent can include a compound of general Formula I or a pharmaceutically acceptable salt, thereof:
  • R 1 and R 2 are independently selected from a hydrogen atom, an alkyl group, C(O)R 3 , and SO 2 R 4 ; R 3 and R 4 are independently selected from an alkyl group, an aryl group, and an aralkyl group; and n is an integer from 2 to 5.
  • the pharmaceutically acceptable salt is free of unsubstituted or substituted tropolone.
  • R 1 and R 2 each comprise a hydrogen atom, or are independently selected from a hydrogen atom and an alkyl group.
  • R 1 or R 2 independently comprise an alkyl group of about one to about ten carbon atoms.
  • R 1 comprises a hydrogen atom and R 2 comprises C(O)R 3 or SO 2 R 4 .
  • R 3 comprises an alkyl group having from about one to about twenty-six carbon atoms, more typically from about six to about sixteen carbon atoms.
  • the oral compositions of the present disclosure can include an anti-inflammatory agent.
  • Any orally acceptable anti-inflammatory agent can be used, including without limitation steroidal agents such as flucinolone and hydrocortisone, and nonsteroidal agents (NSAIDs) such as ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, diclofenac, etodolac, indomethacin, sulindac, tolmetin, ketoprofen, fenoprofen, piroxicam, nabumetone, aspirin, diflunisal, meclofenamate, mefenamic acid, oxyphenbutazone, phenylbutazone, and mixtures thereof.
  • NSAIDs nonsteroidal agents
  • the oral compositions of the present disclosure can include an H 2 antagonist.
  • H 2 antagonist useful herein include , but not limited to, cimetidine, etintidine, ranitidine, ICIA-5165, tiotidine, ORF-17578, lupititidine, donetidine, famotidine, roxatidine, pifatidine, lamtidine, BL-6548, BMY-25271, zaltidine, nizatidine, mifentidine, BMY-52368, SKF-94482, BL-6341A, ICI-162846, ramixotidine, Wy-45727, SR-58042, BMY-25405, loxtidine, DA-4634, bisfentidine, sufotidine, ebrotidine, HE-30-256, D-16637, FRG-8813, FRG-8701, impromidine, L-643728, HB-408.4, and mixtures thereof.
  • the oral compositions of the present disclosure can include a desensitizing agent.
  • Desensitizing agents useful herein include, but not limited to, potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate, strontium salts, arginine and mixtures thereof.
  • a local or systemic analgesic such as aspirin, codeine, acetaminophen, sodium salicylate or triethanolamine salicylate can be used.
  • the oral compositions of the present disclosure can include a nutrient.
  • Suitable nutrients can include without limitation, vitamins, minerals, amino acids, and mixtures thereof.
  • Vitamins include, but not limited to, Vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, and mixtures thereof.
  • Nutritional supplements include, but not limited to, amino acids (such as L-tryptophane, L-lysine, methionine, threonine, levocarnitine and L-carnitine), lipotropics (such as choline, inositol, betaine, and linoleic acid), fish oil (including components thereof such as omega-3 (N-3) polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid), coenzyme Q10, and mixtures thereof.
  • amino acids such as L-tryptophane, L-lysine, methionine, threonine, levocarnitine and L-carnitine
  • lipotropics such as choline, inositol, betaine, and linoleic acid
  • fish oil including components thereof such as omega-3 (N-3) polyunsaturated fatty acids, eicosapentaenoic acid and docosahe
  • the oral compositions of the present disclosure can include proteins.
  • Suitable proteins can include, but are not limited to, milk proteins and enzymes such as peroxide-producing enzymes, amylase, and plaque-disrupting agents such as papain, glucoamylase, glucose oxidase.
  • the oral compositions of the present disclosure can include an inorganic or organic fluoride ion source useful, for example, as an anti-caries agent.
  • Any orally acceptable fluoride ion source can be used, including without limitation potassium, sodium and ammonium fluorides and monofluorophosphates, stannous fluoride, indium fluoride and mixtures thereof.
  • Organic fluorides sources can include tetralkylammonium fluoride or tetralkylammonium tetrafluorborate salts and the like.
  • water-soluble fluoride ion sources are used.
  • the active agent can include at least two different fluoride salts.
  • the active agent can include, but is not limited to, sodium fluoride, strontium fluoride, calcium fluoride, zinc fluoride, calcium chloride, calcium nitrate, calcium phosphates, calcium hydrogen phosphate, calcium dihydrogen phosphate, and combinations thereof.
  • the active agent can provide a sustained fluoride release for at least 24 hours.
  • the oral compositions of the present disclosure can, for example, provide a sustained fluoride release in an oral composition.
  • Embodiment 1 is an oral composition, comprising:
  • a solvent comprising water and a cosolvent chosen from lower alkyl alcohols and acetone;
  • a basic copolymer comprising basic acrylate monomeric units, basic methacrylate monomeric units, or a combination thereof;
  • the oral composition comprises from about 6 to about 15 wt-% of water, from about 30 to about 80 wt-% of the cosolvent, and from about 25 to about 55 wt-% of the basic copolymer;
  • the oral composition is capable of forming a film on a surface when contacted with an aqueous solution
  • Embodiment 2 is the oral composition of embodiment 1, wherein the oral composition further comprises a neutral copolymer comprising neutral acrylate monomeric units, neutral methacrylate monomeric units, or a combination thereof.
  • Embodiment 3 is the oral composition of any proceeding embodiment, wherein the oral composition from about 0 to about 40 wt-% of the neutral copolymer.
  • Embodiment 4 is the oral composition of any preceding embodiment, wherein the neutral copolymer is chosen from Eudragit RS100 and Eudragit RL 100.
  • Embodiment 5 is the oral composition of any preceding embodiment, wherein the basic copolymer is chosen from Eudragit E100 and other copolymer containing dimethylaminoethyl methacrylate for ionic crosslinking
  • Embodiment 6 is the oral composition of any preceding embodiment, wherein the molecular weight of the basic copolymer is from about 10,000 to about 100,000.
  • Embodiment7 is the oral composition of any preceding embodiment, wherein the oral composition is capable of forming the film in less than about 30 seconds after the oral composition is contacted with water.
  • Embodiment 8 is the oral composition of any preceding embodiment, wherein the consistency of the oral composition is from about 45 to about 110.
  • Embodiment 9 is the oral composition of any preceding embodiment, wherein the cosolvent is ethanol.
  • Embodiment 10 is the oral composition of any preceding embodiment, wherein the solvent further comprises at least one additional component chosen from isopropanol, propylene glycol, glycerin, low molecular weight polyethylene glycol, ethylene glycol based ester alcohols, and combinations thereof.
  • Embodiment 11 is the oral composition of any preceding embodiment, wherein the oral composition comprises from about 8 to about 12 wt-% of the water.
  • Embodiment 12 is the oral composition of any preceding embodiment, wherein the oral composition comprises from about 35 to 60 wt-% of the cosolvent.
  • Embodiment 13 is the oral composition of any preceding embodiment, wherein the acid buffering or neutralizing agent is selected from carbonates, bicarbonates, chlorides, hydroxides, dibasic citrates phosphates, sulfates , and combinations thereof
  • Embodiment 14 is the oral composition of any preceding embodiment, wherein the acid buffering or neutralizing agent is selected from phosphate based buffers, hydrogen phosphate based buffers, dihydrogen phosphaste based buffers, carboxylates based buffers, carbonate based buffers, hydrogen carbonate buffers, and combinations thereof
  • Embodiment 15 is the oral composition of any preceding embodiment, wherein the active agent is selected from whitening agents, anticaries agents, fluoride-delivery agents, anti-gingivitis agents, tartar control agents, antiplaque agents, periodontal actives, breath freshening agents, malodor control agents, tooth desensitizers, salivary stimulants, flavors, biofilm disruptors, antimicrobials, anes
  • Embodiment 16 is the oral composition of any preceding embodiment, wherein the active agent is a fluoride composition.
  • Embodiment 17 is the oral composition of any preceding embodiment, wherein the active agent provides a sustained fluoride release for at least 24 hours.
  • Embodiment 18 is the oral composition of any preceding embodiment, wherein the active agent comprises at least two different fluoride salts.
  • Embodiment 19 is the oral composition of any preceding embodiment, wherein the active agent is chosen from sodium fluoride, strontium fluoride, calcium fluoride, zinc fluoride, calcium chloride, calcium nitrate, calcium phosphates, calcium hydrogen phosphate, calcium dihydrogen phosphate, and combinations thereof.
  • Embodiment 20 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for at least 5 strokes.
  • Embodiment 21 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for at least 10 strokes.
  • Embodiment 22 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for at least 20 strokes.
  • Embodiment 23 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for at least 30 strokes.
  • Embodiment 24 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for at least 60 strokes.
  • Embodiment 25 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for at least 90 strokes.
  • Embodiment 26 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for at least 120 strokes.
  • Embodiment 27 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for from 5 to 120 strokes.
  • Embodiment 28 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for from 10 to 90 strokes.
  • Embodiment 29 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for from 20 to 60 strokes.
  • Embodiment 30 is the oral composition of any preceding embodiment, wherein the film remains on at least 90% of the surface after brushing the surface for from 5 to 120 strokes.
  • Polymer solutions were prepared by first weighing the designated amount of solvent into a 250 ml jar that has a cap. The designated amount of polymer material was then added to the jar. The jar was sealed and then placed on a Wheaton Culture Roller for 2-3 days ( ⁇ 30rpm) until the polymer was completely dissolved in the solvent. Additional ingredients such as NaF, other salts, viscosity modifiers, flavorings, etc. were added to the polymer solution using two 2 minute cycles in a speed mixer (SpeedMixer DAC150.1 FVZ available from FlacTek, Inc., Landrum, S.C.) set at 3000rpm. The materials used in each coating composition as well as the amount (in grams) are shown in the examples and tables below.
  • compositions of the invention and comparative compositions were coated onto a glass (or plastic if noted) slide (available from VWR, Radnor Pa.) or bovine teeth using a cotton swab or small brush.
  • the coated substrate what then dipped into a container of tap water for 30 seconds at room temperature ( ⁇ 25° C.).
  • the coating was then qualitatively evaluated to determine if a film had formed (“set”). Additionally the set films were evaluated at to their adhesion to the substrate. Adhesion was deemed “good” when the set film could not be pushed away by finger pressure and “no” when the set film could be pushed away by finger pressure.
  • Abrasion resistance was evaluated by brushing the set coating with a tooth brush and counting the number of brush strokes required to remove the coating.
  • Approximately 40-50 mg of coating composition was evenly painted onto a 1 inch ⁇ 1 inch plastic slide (Rinzyl plastic micro slide available from VRW, Radnor, Pa.).
  • the coated slide was immersed in 25 ml of deionized water in a plastic test tube for 1 hour. After 1 hour, the slide was removed, rinsed and immersed in a second 25 ml aliquot of water in another test tube. After 3 more hours (4 hours total), the process was repeated and the slide was immersed in a third 25 ml aliquot of water. After 2 more hours (6 hours total) the process was again repeated and the slide was place in a fourth 25 ml aliquot of water where it remained for an additional 18 hours (24 hours total) before being removed.
  • Bovine teeth were potted in a poly(methyl)methacrylate (PMMA) resin and then polished with 320 grit sandpaper to expose the enamel surface. The exposed enamels were wiped with paper tower to remove excess of water, then coated with about 10 mg materials to form a thin layer on enamel, and then stored in 37° C. artificial saliva for varying amounts of time.
  • a tooth brush machine (available from Foth Production Solution, LLC, Greenbay Wis.) was used to test coating wear durability on enamel. Tooth brush head was cut from tooth brush with brand name Acclean gentle care from Henry Schein and inserted into the fixture on the tooth brush machine. The potted bovine teeth were inserted and fixed in a plastic port filled with brush media. The tooth brush head was rest on the coating surface.
  • the machine can control the tooth brush head moving back and forth against the coating on enamel.
  • the brushing stroke is defined as brushing the surface back and forth one time. 5 ml of 1:1 water and tooth paste (CREST cavity protection tooth paste) mixture was used as brush media. After certain brushing strokes, the coating surfaces were checked and the amount of wear was estimated.
  • the pH of the coating solutions was determined using pH paper.
  • compositions were prepared and coated as described above using the materials and amounts (in grams) as outlined in Table 1 below. Coated films were evaluated for set, adhesion and fluoride release as described above.
  • Coating compositions were prepared and coated as described above using the materials and amounts (in grams) as outlined in Table 2 below. Coated films were evaluated for set, adhesion and fluoride release as described above.
  • Coating compositions were prepared and coated as described above using the materials and amounts (in grams) as outlined in Table 3 below.
  • the pH of the coating composition was determined as described above and the coated films were evaluated for set and adhesion.
  • Coating compositions were prepared and coated as described above using the materials and amounts (in grams) as outlined in Table 4 below. The coated films were evaluated for set, adhesion and fluoride release as described above.
  • the pH of the coating compositions outlined in Table 4 was determined using pH paper as described above. Coatings were then prepared as described above by placing about 25 mg of coating composition on a 2.5 cm ⁇ 2.5 cm square glass slide and then dipping the coated slide into tap water for 30 seconds to form a hard film. The coated slides were removed from the tap water and then dipped into 100 ml of water that was adjusted to pH 4 with a trace amount of 37% phosphoric acid. After 10 seconds the coated slides were removed from the acid adjusted water and the pH of the acid adjusted water on the wet coated surface was determined using pH paper. The results of this buffering test are shown in Table 4 below.
  • the abrasion resistance on bovine teeth of coating composition of Ex 6 and 7 was determined as described above. Three replicate samples of coated teeth were soaked in 37° C. artificial saliva for either 3 hours or 24 hours and then subjected to brushing. The amount of coating removed after a specific number of brush strokes is reported in Table 5 below.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
US14/917,442 2013-09-11 2014-09-04 Oral compositions Abandoned US20160220472A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/917,442 US20160220472A1 (en) 2013-09-11 2014-09-04 Oral compositions

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361876441P 2013-09-11 2013-09-11
US14/917,442 US20160220472A1 (en) 2013-09-11 2014-09-04 Oral compositions
PCT/US2014/054074 WO2015038400A1 (en) 2013-09-11 2014-09-04 Oral compositions

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/054074 A-371-Of-International WO2015038400A1 (en) 2013-09-11 2014-09-04 Oral compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/585,341 Continuation US10772821B2 (en) 2013-09-11 2019-09-27 Oral compositions

Publications (1)

Publication Number Publication Date
US20160220472A1 true US20160220472A1 (en) 2016-08-04

Family

ID=51656051

Family Applications (2)

Application Number Title Priority Date Filing Date
US14/917,442 Abandoned US20160220472A1 (en) 2013-09-11 2014-09-04 Oral compositions
US16/585,341 Active US10772821B2 (en) 2013-09-11 2019-09-27 Oral compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
US16/585,341 Active US10772821B2 (en) 2013-09-11 2019-09-27 Oral compositions

Country Status (6)

Country Link
US (2) US20160220472A1 (enExample)
EP (1) EP3043869B1 (enExample)
JP (1) JP6480458B2 (enExample)
CN (1) CN105530998B (enExample)
RU (1) RU2646501C2 (enExample)
WO (1) WO2015038400A1 (enExample)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019048962A1 (en) * 2017-09-08 2019-03-14 3M Innovative Properties Company AQUEOUS FLUORIDE TREATMENT COMPOSITIONS FOR ORAL CARE, AND METHODS
WO2020081050A1 (en) * 2018-10-16 2020-04-23 Colgate-Palmolive Company Oral care compositions and methods for the same
WO2020081049A1 (en) * 2018-10-16 2020-04-23 Colgate-Palmolive Company Oral care compositions and methods for the same
WO2020081051A1 (en) * 2018-10-16 2020-04-23 Colgate-Palmolive Company Oral care compositions and methods for the same
US10682300B2 (en) 2017-09-29 2020-06-16 3M Innovative Properties Company Aqueous oral care fluoride treatment compositions, and methods
US11154487B2 (en) 2018-10-16 2021-10-26 Colgate-Palmolive Company Oral care compositions and methods for the same
US11173105B2 (en) 2018-10-16 2021-11-16 Colgate-Palmolive Company Oral care compositions and methods for the same
US11260016B2 (en) 2018-10-16 2022-03-01 Colgate-Palmolive Company Oral care compositions and methods for the same
US20230263735A1 (en) * 2020-07-13 2023-08-24 Kirin Holdings Kabushiki Kaisha Film coated tablet
US12031128B2 (en) 2021-04-07 2024-07-09 Battelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
US12109223B2 (en) 2020-12-03 2024-10-08 Battelle Memorial Institute Polymer nanoparticle and DNA nanostructure compositions and methods for non-viral delivery
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems
US12458606B2 (en) 2023-09-29 2025-11-04 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105530999B (zh) 2013-09-11 2019-08-16 3M创新有限公司 口腔组合物、牙齿结构以及递送口腔组合物的方法
JP2019115647A (ja) * 2017-12-26 2019-07-18 株式会社広栄社 アルカリ性メラミンフォーム製品とその製造方法。
EP4340806A4 (en) 2021-05-18 2025-04-09 Solventum Intellectual Properties Company NON-AQUEOUS COMPOSITION DENTAL APPLIANCE
US20220394979A1 (en) * 2021-06-14 2022-12-15 Pinnacle Environmental Solutions, LLC Multipurpose disinfection solutions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000021582A1 (en) * 1998-10-09 2000-04-20 A.C.R. Applied Coating Research S.A. Coumarin-based or melilot-based transdermal plasters

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134935A (en) * 1971-08-12 1979-01-16 Bayer Aktiengesellschaft Dental varnishes
US4883534A (en) 1983-05-11 1989-11-28 University Of Toronto Innovations Foundations Benzoin antimicrobial dental varnishes
JPS61289006A (ja) 1985-06-17 1986-12-19 Sunstar Inc 歯科用接着性コ−テイングベ−ス組成物
JPH0729915B2 (ja) * 1986-02-01 1995-04-05 帝國製薬株式会社 シ−ト状口腔内貼付剤
US5288480A (en) 1987-01-30 1994-02-22 Colgate-Palmolive Co. Antiplaque antibacterial oral composition
JPS6477896A (en) 1987-09-18 1989-03-23 Ito Seitetsushiyo Kk Electrode extension connection device in electric furnace
US5438076A (en) 1988-05-03 1995-08-01 Perio Products, Ltd. Liquid polymer composition, and method of use
US5160737A (en) 1988-05-03 1992-11-03 Perio Products Ltd. Liquid polymer composition, and method of use
US5330746A (en) 1988-05-03 1994-07-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Dental varnish composition, and method of use
DE3827561C1 (enExample) 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
US5249206A (en) 1989-08-11 1993-09-28 International Business Machines Corporation Fault-tolerant clock for multicomputer complex
WO1994004126A2 (en) * 1992-08-18 1994-03-03 Unilever N.V. Polymeric anticalculus agents
US5521293A (en) 1992-11-25 1996-05-28 Lever Brothers Company, Division Of Conopco, Inc. Heteroatom containing alkyl aldonamide compounds as superior foaming, more soluble nonionic surfactants and a process for their manufacture
JP3022039B2 (ja) * 1993-03-05 2000-03-15 サンスター株式会社 歯牙着色防止用口腔用組成物
JP3590438B2 (ja) * 1995-03-31 2004-11-17 サンスター株式会社 口腔用組成物
JPH08325128A (ja) * 1995-03-31 1996-12-10 Sunstar Inc 口腔用長期滞留型基剤およびそれを用いた組成物
DE19629167C2 (de) * 1996-07-19 2000-05-04 Einhorn Apotheke Dr Guenther H Feste orale, antikariogene Zusammensetzung in Form einer Lutschtablette zum Reinigen der Mundhöhle und Zähne
AU2001285875A1 (en) 2000-08-07 2002-02-18 S And C Polymer Silicon- Und Composite-Spezialitaten Gmbh Adhesive fluoride varnish
DK1322276T3 (da) * 2000-09-26 2006-07-31 Thomas R Patacca Tandbelægningssammensætning
US6485709B2 (en) 2001-01-23 2002-11-26 Addent Inc. Dental bleaching gel composition, activator system and method for activating a dental bleaching gel
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US20050113510A1 (en) * 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
EP1262172A1 (en) * 2001-05-25 2002-12-04 Italmed S.N.C. Di Galli G. & Pacini G. Liquid polymer composition for prevention and treatment of the oral cavity diseases
US6854973B2 (en) 2002-03-14 2005-02-15 Orametrix, Inc. Method of wet-field scanning
US6770266B2 (en) 2002-05-24 2004-08-03 Colgate Palmolive Company Liquid tooth whitening composition
RU2351315C2 (ru) * 2003-07-24 2009-04-10 Смитклайн Бичам Корпорейшн Пленки, растворяющиеся в полости рта
US20050063921A1 (en) 2003-09-19 2005-03-24 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Oral composition
US20050196355A1 (en) 2004-03-03 2005-09-08 Constantine Georgiades Film products having controlled disintegration properties
US7335691B2 (en) 2004-07-02 2008-02-26 Scientific Pharmaceuticals, Inc. Caries preventive desensitizing and fluoridizing dental varnishes
US20060024246A1 (en) * 2004-07-29 2006-02-02 Prithwiraj Maitra Oral care compositions with film forming polymers
JP2009522003A (ja) 2005-12-29 2009-06-11 スリーエム イノベイティブ プロパティズ カンパニー 発泡性歯科用組成物及び方法
AU2007289171A1 (en) 2006-09-01 2008-03-06 Smithkline Beecham Corporation Denture care composition
WO2009014907A1 (en) 2007-07-25 2009-01-29 3M Innovative Properties Company Therapeutic dental composition and related methods
US7963769B2 (en) 2007-10-08 2011-06-21 Kerr Corporation Dental adhesive and method of use
US8383163B2 (en) 2008-01-29 2013-02-26 Ultradent Products, Inc. Fluoride varnish compositions including an organo phosphoric acid adhesion promoting agent
EP2296577A1 (en) 2008-06-09 2011-03-23 Densys Ltd. Intra-oral surface non-aqueous hydrophobic coating composition and method
BRPI0914713A2 (pt) 2008-06-27 2017-05-23 Novamin Tech Inc composição para cuidado oral
US8632754B2 (en) * 2009-08-03 2014-01-21 Mcneil-Ppc, Inc. Tooth sensitivity treatment compositions
WO2011042897A1 (en) * 2009-10-05 2011-04-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd Liquid precursor compositions and uses thereof for a ph-dependant sustained release treatment of oral disorders
TWI499430B (zh) * 2009-12-17 2015-09-11 Colgate Palmolive Co 抗侵蝕的牙膏組成物
US20130101967A1 (en) 2010-06-24 2013-04-25 3M Innovative Properties Company Aqueous composition suitable for intra-oral scanning methods
RU2517142C2 (ru) 2012-04-27 2014-05-27 Общество с ограниченной ответственностью "Инновационные полимерные адгезивы" Гидрофильный чувствительный к давлению биоадгезив с целенаправленной адгезией к зубам и композиция для ухода за зубами на его основе
CN102846488A (zh) * 2012-09-17 2013-01-02 江苏隆力奇生物科技股份有限公司 一种牙齿美化液
CN105530999B (zh) 2013-09-11 2019-08-16 3M创新有限公司 口腔组合物、牙齿结构以及递送口腔组合物的方法
WO2015038376A1 (en) 2013-09-11 2015-03-19 3M Innovative Properties Company Coating compositions, dental structures thereof and methods for generating contrast
WO2015071386A1 (en) 2013-11-14 2015-05-21 Koninklijke Philips N.V. System and method for applying oral care agents
WO2015160762A1 (en) 2014-04-14 2015-10-22 3M Innovative Properties Company Oral compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000021582A1 (en) * 1998-10-09 2000-04-20 A.C.R. Applied Coating Research S.A. Coumarin-based or melilot-based transdermal plasters

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019048962A1 (en) * 2017-09-08 2019-03-14 3M Innovative Properties Company AQUEOUS FLUORIDE TREATMENT COMPOSITIONS FOR ORAL CARE, AND METHODS
US11666523B2 (en) * 2017-09-08 2023-06-06 3M Innovative Properties Company Aqueous oral care fluoride treatment compositions, and methods
AU2018330662B2 (en) * 2017-09-08 2021-12-02 Solventum Intellectual Properties Company Aqueous oral care fluoride treatment compositions, and methods
US11337902B2 (en) 2017-09-29 2022-05-24 3M Innovative Properties Company Aqueous oral care fluoride treatment compositions, and methods
US10682300B2 (en) 2017-09-29 2020-06-16 3M Innovative Properties Company Aqueous oral care fluoride treatment compositions, and methods
CN113015516A (zh) * 2018-10-16 2021-06-22 高露洁-棕榄公司 口腔护理组合物及用于其的方法
WO2020081050A1 (en) * 2018-10-16 2020-04-23 Colgate-Palmolive Company Oral care compositions and methods for the same
US11173105B2 (en) 2018-10-16 2021-11-16 Colgate-Palmolive Company Oral care compositions and methods for the same
WO2020081051A1 (en) * 2018-10-16 2020-04-23 Colgate-Palmolive Company Oral care compositions and methods for the same
US11260016B2 (en) 2018-10-16 2022-03-01 Colgate-Palmolive Company Oral care compositions and methods for the same
WO2020081049A1 (en) * 2018-10-16 2020-04-23 Colgate-Palmolive Company Oral care compositions and methods for the same
AU2018445624B2 (en) * 2018-10-16 2022-11-10 Colgate-Palmolive Company Oral care compositions and methods for the same
AU2018445788B2 (en) * 2018-10-16 2022-12-01 Colgate-Palmolive Company Oral care compositions and methods for the same
AU2018446162B2 (en) * 2018-10-16 2023-01-19 Colgate-Palmolive Company Oral care compositions and methods for the same
US11154487B2 (en) 2018-10-16 2021-10-26 Colgate-Palmolive Company Oral care compositions and methods for the same
US12194130B2 (en) 2018-10-16 2025-01-14 Colgate-Palmolive Company Oral care compositions and methods for the same
US12097278B2 (en) 2018-10-16 2024-09-24 Colgate-Palmolive Company Oral care compositions and methods for the same
US20230263735A1 (en) * 2020-07-13 2023-08-24 Kirin Holdings Kabushiki Kaisha Film coated tablet
US12109223B2 (en) 2020-12-03 2024-10-08 Battelle Memorial Institute Polymer nanoparticle and DNA nanostructure compositions and methods for non-viral delivery
US12433910B2 (en) 2020-12-03 2025-10-07 Battelle Memorial Institute Polymer nanoparticle and DNA nanostructure compositions and methods for non-viral delivery
US12031128B2 (en) 2021-04-07 2024-07-09 Battelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
US12458606B2 (en) 2023-09-29 2025-11-04 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems

Also Published As

Publication number Publication date
US20200022896A1 (en) 2020-01-23
JP6480458B2 (ja) 2019-03-13
RU2016110110A (ru) 2017-10-16
WO2015038400A1 (en) 2015-03-19
EP3043869B1 (en) 2018-10-24
CN105530998A (zh) 2016-04-27
CN105530998B (zh) 2018-09-21
JP2016530309A (ja) 2016-09-29
RU2646501C2 (ru) 2018-03-05
EP3043869A1 (en) 2016-07-20
US10772821B2 (en) 2020-09-15

Similar Documents

Publication Publication Date Title
US10772821B2 (en) Oral compositions
US10064802B2 (en) Oral compositions, dental structures and methods of delivering oral compositions
US10959936B2 (en) Oral care composition with cross-linked polymer peroxide
EP1771227B1 (en) Oral care compositions with film forming polymers
RU2433815C2 (ru) Композиции для доставки веществ для ухода за полостью рта, содержащие силиконовые чувствительные к давлению адгезивы
US9308399B2 (en) Tooth whitening composition
MXPA06006945A (es) Sistema de suministro para el cuidado bucal que comprende un agente blanqueador.
JP7115722B2 (ja) 水性口腔ケア溶液、方法、キット、及び該口腔ケア溶液から誘導されたコーティングを有する歯表面
US20240009093A1 (en) Compositions comprising an iodide or thiocyanate, and methods for treating teeth
JP2015155437A (ja) 歯のホワイトニング組成物

Legal Events

Date Code Title Description
AS Assignment

Owner name: 3M INNOVATIVE PROPERTIES COMPANY, MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WANG, YIZHONG;OXMAN, JOEL D.;TON, TIFFANY T.;REEL/FRAME:039349/0890

Effective date: 20160803

STCV Information on status: appeal procedure

Free format text: ON APPEAL -- AWAITING DECISION BY THE BOARD OF APPEALS

STCV Information on status: appeal procedure

Free format text: BOARD OF APPEALS DECISION RENDERED

STCB Information on status: application discontinuation

Free format text: ABANDONED -- AFTER EXAMINER'S ANSWER OR BOARD OF APPEALS DECISION