US20150353219A1 - Installation and method for individually tailored filling of blister packs with medication according to predetermined prescription data - Google Patents

Installation and method for individually tailored filling of blister packs with medication according to predetermined prescription data Download PDF

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Publication number
US20150353219A1
US20150353219A1 US14/760,599 US201414760599A US2015353219A1 US 20150353219 A1 US20150353219 A1 US 20150353219A1 US 201414760599 A US201414760599 A US 201414760599A US 2015353219 A1 US2015353219 A1 US 2015353219A1
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Prior art keywords
filling
medication
blister packs
blister
pack
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Abandoned
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US14/760,599
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English (en)
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Edwin Kohl
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Individual
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Individual
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B65B57/02—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages
    • B65B57/04—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages and operating to control, or to stop, the feed of such material, containers, or packages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
    • B65B43/52—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation using roller-ways or endless conveyors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
    • B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
    • B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00—Unpacking of articles or materials, not otherwise provided for
    • B65B69/005—Unpacking of articles or materials, not otherwise provided for by expelling contents, e.g. by squeezing the container
    • B65B69/0058—Solid contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B2220/00—Specific aspects of the packaging operation
    • B65B2220/14—Adding more than one type of material or article to the same package

Definitions

  • the invention relates to an installation and to a method for individually tailored filling of blister packs with medication according to predetermined prescription data, the blister packs having receiving compartments for respective medication administration units, said compartments being arranged in a matrix configuration in rows corresponding to a number of intake times during a day and columns corresponding to a number of days, for example weekdays.
  • DE 10 2004 034 024 A2 discloses an individual blister pack for the weekly medication requirement of a patient (weekly blister) who is to take the medication in a sequence arranged according to date, day of the week and time of day (morning, midday and evening and/or night).
  • the receiving compartments of the blister pack for receiving the respective medication are arranged in matrix form with seven day columns each with at least three time-of-day compartments which are sealed overall by a continuous blister film.
  • a box-shaped lid containing the composition of the individual time-of-day compartments and prescription information relating to the respective medication is attached to the blister pack.
  • weekly blister packs of this type are an aid, on the one hand, for not forgetting to take important medication and, on the other hand, also for retaining a reliable overview of what medications have already been taken in order to avoid potentially harmful overmedication.
  • WO 2005 102 841 A1 discloses an installation for filling blister packs of this type tailored to the patient with the desired combination of medications.
  • an output station is provided, which by means of rams assigned spatially to the receiving compartments of the blister pack conveys the respective medication from a temporary packaging in the form of a blister strip into the corresponding receiving compartments of the packaging unit.
  • All of the blister packs tailored to the patient pass through all of the output stations of the installation in cycles, medication being taken up only at those stations which correspond to the prescription data assigned to the individual blister pack.
  • Packaging units tailored to the patient can in this way be fully automatically filled safely and reliably with a selection from several hundred medications.
  • the object is achieved by an installation for individually tailored filling of blister packs with medication according to predetermined prescription data, the blister packs having receiving compartments for respective medication administration units, said compartments being arranged in a matrix configuration in rows corresponding to a number of intake times during a day and columns corresponding to a number of days, for example weekdays, comprising a number of medication filling stations arranged one after the other for filling the blister packs with in each case a particular medication, characterised by a transport device constructed for transporting the blister packs individually one after the other in a direction of movement alongside the medicament filling stations, each blister pack being guided individually in a manner such that said pack approaches only the medication filling stations required in each case according to the prescription data for a filling operation, bypassing the other medicament filling stations, and is directly conveyed onwards to the next required medication filling station or to a position behind a preceding blister pack present at a medication filling station, or up to the point of removal of the filled blister from the workpiece carrier.
  • the object is furthermore achieved by a method for individually tailored filling of blister packs with medication according to predetermined prescription data, the blister packs having receiving compartments for respective medication administration units, said compartments being arranged in a matrix configuration in rows corresponding to a number of intake times during a day and columns corresponding to a number of days, for example weekdays, which method comprises conveying the blister packs individually one after the other in a direction of movement alongside medication filling stations arranged one after the other for filling the blister packs with in each case a particular medication, each blister pack being guided individually in a manner such that said pack approaches only the medication filling stations required in each case according to the prescription data for a filling operation, bypassing the other medication filling stations, and is directly conveyed onwards to the next required medication filling station or to a position behind a preceding blister pack present at a medication filling station.
  • the blister packs are driven by means of a magnetic track with a linear motor, as a result of which individual control and reliable transport of a large number of blister packs is possible.
  • workpiece carriers guided in a magnetic track are provided for receiving the blister packs, which workpiece carriers are conveyed in a closed circuit, the blister packs being placed on the workpiece carriers before being filled and being removed again after the filling operation.
  • a column of a blister pack corresponding to a number of days can be filled simultaneously in one working step.
  • each filling station has a movable premetering cartridge for filling the blister packs, as a result of which the time-critical operation of filling the blister pack is decoupled from the mechanically difficult operation of ejecting the medication units out of the blister strip.
  • the installation can furthermore have a camera arranged above the transport device for visual checking of the correct filling of the blister pack according to the prescription data.
  • a plurality of filling stations can be combined in this case to form filling modules, such a camera being provided after each filling module.
  • a clean room region is provided to create clean room conditions during filling of the blister packs.
  • the method according to the invention preferably comprises the method step of establishing and attaching a documentation carrier on the blister pack, comprising information relating to the individual and/or information on the use of the medication packaged in the blister pack.
  • the sequence of the blister packs filled in succession can be specified according to the requirements of the recipients of the filled blister packs without a loss in the efficiency of the installation, as a result of which dispatch and marketing of the filled blister packs is simplified considerably.
  • FIG. 1 is a schematic detailed view from above of an embodiment of an installation according to the invention for individually tailored filling of blister packs.
  • FIG. 2 is an embodiment of a blister pack for use with the installation according to the invention.
  • FIG. 3 is a schematic detailed view from above to show the progress of the method for filling a blister pack according to an embodiment of the invention.
  • FIG. 4 is a perspective view of an embodiment of a premetering cartridge of the installation according to the invention.
  • FIG. 5 is a schematic detailed internal view of an embodiment of a medication output station according to the invention.
  • FIG. 6 is a schematic cross-sectional view to show the progress of the method for filling a blister pack according to an embodiment of the invention.
  • FIG. 7 is a flow diagram to explain the method steps of an embodiment of the method according to the invention for individually tailored filling of blister packs.
  • FIG. 8 is a diagram of an embodiment of an installation according to the invention for individually tailored filling of blister packs to explain the transport of the blister packs in the installation.
  • FIG. 1 is a schematic plan view of a filling module 41 of an embodiment of the installation according to the invention for individually tailored filling of blister packs 25 .
  • a filling module 41 comprises five medication filling stations 40 arranged one after the other, each of which is provided for output of dosing units of a particular medication type.
  • the number of medication filling stations 40 combined in a filling module 41 is of course not limited to five, but can be selected according to space conditions or expediency.
  • the total number of medication filling modules 41 in the installation is not limited to a particular number.
  • the total number of filling stations 40 in this context determines the maximum number of medications which can be blister-packed with the installation, it also being possible for more than one filling station to be provided for medications which are used particularly frequently.
  • FIG. 2 a shows an embodiment of a blister pack 25 for use with the installation according to the invention in perspective view
  • FIGS. 2 b and 2 c in cross-sectional view with and without the blister film 27 , respectively.
  • the blister pack 25 has receiving compartments 26 arranged in a matrix configuration, which in the embodiment shown are arranged in four rows corresponding to a number of intake times during a day (morning, midday, evening, night) and seven columns corresponding to the days of a week.
  • the invention is not limited to this specific arrangement of the receiving compartments 26 of the blister pack.
  • a guide rail 11 is shown constructed as a magnetic rail 11 for transporting the blister packs 25 , which in this case lie on a workpiece carrier 20 (shown schematically in FIG. 6 ).
  • the workpiece carrier 20 is provided with troughs (not shown) corresponding to the arrangement of the receiving compartments 26 of the blister pack 25 .
  • the blister packs 25 are placed on the workpiece carrier 20 and pass individually and one after the other through the entire path from the first filling station to the last filling station of the filling installation. Each blister pack is thereby controlled individually and stops only at those filling stations 40 at which a medication filling operation into the respective blister pack 25 is required according to the prescription data of the respective patient.
  • a blister pack 25 thus stops at three to seven filling stations at which the respective medication is fed in rows by means of a premetering cartridge 50 , as will be explained in detail later with reference to FIGS. 3 to 6 .
  • a clean room region is provided, which is given the reference numeral 30 in FIG. 1 .
  • germ-free and low-particle air is blown from the roof downwards, which prevents germs or undesirable dust particles from entering into the opened blister pack 25 .
  • a phototunnel 32 with a camera (not shown) is provided, which establishes a visual image of the blister pack 25 after passing through the preceding filling module 41 .
  • evaluation electronics can check whether the filling with medication has been correctly implemented according to the respective prescription data of the patient.
  • FIG. 4 is a schematic plan view and FIG. 6 is a cross-sectional view of the medication filling operation at a medication filling station 40 .
  • the filling module 25 is first conveyed with the aid of the workpiece carrier 20 to the envisaged medication filling module 40 .
  • the filling module 20 stops its movement and the premetering cartridge 50 performs a movement perpendicular to the direction of movement of the blister pack, as indicated in FIGS. 6 a and 6 b by means of an arrow.
  • a premetering compartment 51 is in each case to be found over a weekday compartment 26 of a row of the blister pack 25 ( FIG. 3 a and FIG. 6 c ).
  • the opening mechanism of the premetering cartridge 50 is then activated, so that the medications present in the premetering compartments 51 drop from a low dropping height into the corresponding compartments 26 of the blister pack 25 .
  • the opening mechanism of the premetering cartridge is constructed as a displaceable base 55 of the premetering cartridge.
  • Other mechanisms, such as folding mechanisms or the like, however, are likewise possible in the context of the invention. If the medication 28 “dispensed” at the output station 40 is still required in another day row of the blister pack 25 (for example for a medicament intake in the morning and evening), the blister pack remains in position (not completely, it is already transported further by a corresponding number of rows), and the premetering cartridge 50 moves back ( FIG.
  • FIG. 4 An embodiment of a premetering cartridge 50 is shown in a schematic perspective view in FIG. 4 .
  • a total of seven premetering compartments 71 is provided, corresponding to the seven weekday columns of the blister pack 25 , a different number of compartments 51 also being possible according to the invention.
  • the premetering compartments 51 are constructed in the form of a transparent internal lining made of plastics material which can be replaced for cleaning purposes and which can be fixed on a stable frame part 54 preferably made of metal.
  • slots 52 are provided on both sides for visual checking of whether or not a medication is present in the respective premetering compartment.
  • the mechanism for feeding the medication 28 into the premetering cartridge 50 of a medication filling station 40 is shown schematically in FIG. 5 .
  • the medication is fed by means of a continuous blister strip 45 which has blister pockets 46 arranged equidistantly for receiving the medication dosages, the distance between the individual blister pockets 46 of the blister strip 45 corresponding to the distance of the premetering compartments 51 of the premetering cartridge 50 .
  • the blister strip 45 present in the respective medication filling stations 40 is preferably unrolled from a roll known per se with the aid of a drive mechanism (not shown).
  • a new, filled blister strip roll can be mounted in the medication filling station 40 and/or the new blister strip can be glued or fastened directly on to the existing blister strip without difficulty, so that an uninterrupted supply of medication is ensured.
  • at least one medication filling station 40 can be provided for manual filling of the premetering cartridge 50 . It is thereby possible to increase the flexibility of the installation and also to accommodate very rarely prescribed medication in the blister-packing under economic conditions.
  • each medication filling station 40 has ejector rams 42 for ejecting the medication 28 out of the blister strip 45 into the premetering cartridge 50 .
  • the ejector rams 42 are provided in a number corresponding to the number of premetering compartments 51 of the premetering cartridge 50 for time-saving parallel ejection of the medication units; however, this is not absolutely necessary and sequential ejection of the medication is likewise possible.
  • a medication filling station 40 has at least two sensor devices 47 , 48 for checking the correct blister strip-premetering cartridge-blister pack transfer of medication.
  • a first transmitted light camera or light barrier 47 ascertains through the slots 52 provided on the premetering compartments 51 whether a medication is present in the corresponding premetering compartment 51 during the outwards movement of the premetering cartridge 50 and whether it is no longer present therein during the later inwards movement, as a result of which the correct release of the medication units into the corresponding compartments of the blister pack can be validated.
  • an incident light camera 48 is preferably provided which likewise visually validates the filling status of the premetering compartments 51 before transfer of medication to the blister pack and thereafter, either by means of reflected light or as a transmitted light detector.
  • the base of the premetering cartridge 50 must be constructed to be transparent to light.
  • the use of the premetering cartridge 50 in the filling installation according to the invention ensures that the ejection operation from the blister strip 45 and the filling operation of the blister pack 25 are decoupled from one another.
  • the filling operation of the blister pack 25 which is time-critical for the efficiency of the entire installation can be optimised with respect to speed, while more time is available for the ejection operation from the blister strip 45 , which is mechanically difficult to perform, without the efficiency of the entire installation being impaired.
  • a magnetic rail system 10 with a linear motor drive is preferably provided, which rail system allows each workpiece carrier 20 and therefore the blister pack 25 present thereon to be guided individually.
  • the magnetic rail system 10 has a self-contained guide rail 11 , shown in cross section in FIG. 6 .
  • Each workpiece carrier 20 has a guide element 12 which surrounds the guide rail 11 and is guided in the guide rail 11 with or without contact (sliding, rolling) in a manner known per se in accordance with the principle of a magnetic levitation train.
  • An electric linear motor which is likewise known per se ensures the individually controllable propulsion of the workpiece carrier 20 and therefore of the blister pack 25 .
  • a blister pack feeding station 60 is provided, shown schematically in FIG. 8 .
  • a blister pack removal station 61 is correspondingly arranged at the end of the filling zone.
  • a first method step S 2 ( FIG. 7 ) an empty blister pack 25 is thus placed on the workpiece carrier 20 in the blister pack feeding station 60 .
  • the filling stations to be approached in the embodiment shown in FIG. 8 these are stations A, B and C, are then (or simultaneously) determined.
  • the transport path to the next filling station to be approached is occupied by a preceding blister pack involved in a filling operation at a filling station lying in between. If this is the case the blister pack 25 in question follows or waits for the preceding blister pack according to method step S 8 .
  • step S 10 the blister pack 25 travels according to step S 10 at the maximum transport speed to this next medication filling station 40 , where the filling operation is carried out in method step S 12 .
  • Method steps 86 to 812 are repeated until it is ascertained in step S 14 that the last envisaged filling station is reached.
  • step S 16 the blister pack is then removed at the blister pack removal station 61 , the blister pack 25 is sealed with the blister film 27 and an information card (not shown) with patient identification information and prescription information for the patient is printed and this information card is attached to the blister. Finally, the filled blister pack 25 provided with the information card is ready for dispatch (step S 20 ).
  • FIG. 8 shows schematically the various states of movement of the blister pack.
  • State of movement ( 1 ) shown by a cross-hatched rectangle with an arrow, designates a forward movement with maximum speed to the next medication filling station to be guided towards or to a “waiting line” of preceding blister packs
  • state of movement ( 2 ) shown by a solid rectangle, designates a filling operation at a medication filling station 40
  • state of movement ( 3 ) shown by a cross-hatched rectangle without an arrow, designates a forwards movement of the blister pack in a “waiting line” behind a preceding blister pack
  • state of movement ( 4 ) shown by a rectangle with a cross, designates the return movement of an empty workpiece carrier 20 to the blister pack feeding station 60 .
  • the invention makes possible considerably faster passage of the individual blister packs through the installation and therefore increased efficiency compared with conventional cyclic operation. If a filling station 40 drops out briefly because of maintenance work or changing of the blister strip, this does not require the entire installation to be stopped. Replacement of a defective filling station by a new filling station is also possible without problems, without shutting down the entire installation.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Public Health (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Basic Packing Technique (AREA)
US14/760,599 2013-01-14 2014-01-07 Installation and method for individually tailored filling of blister packs with medication according to predetermined prescription data Abandoned US20150353219A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13151164.4 2013-01-14
EP13151164.4A EP2754614B1 (de) 2013-01-14 2013-01-14 Anlage und Verfahren zur personenbezogenen Befüllung von Blisterpackungen mit Medikamenten
PCT/EP2014/050148 WO2014108399A1 (de) 2013-01-14 2014-01-07 Anlage und verfahren zur personenindividuellen bestückung von befüllblistern mit medikamenten entsprechend vorgegebenen verschreibungsdaten

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US20150353219A1 true US20150353219A1 (en) 2015-12-10

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US14/760,599 Abandoned US20150353219A1 (en) 2013-01-14 2014-01-07 Installation and method for individually tailored filling of blister packs with medication according to predetermined prescription data

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US (1) US20150353219A1 (zh)
EP (1) EP2754614B1 (zh)
CN (1) CN105050899B (zh)
CA (1) CA2897746A1 (zh)
WO (1) WO2014108399A1 (zh)

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US20140305073A1 (en) * 2013-04-12 2014-10-16 Marchesini Group S.P.A. System for synchronising work stations of a blister-packing machine with advancement of a blister pack
WO2018049123A3 (en) * 2016-09-09 2018-04-19 The Procter & Gamble Company System and method for independently routing container-loaded vehicles to create different finished products
NL2019530B1 (nl) * 2017-09-12 2019-03-27 Canister Dev B V Inrichting voor verpakken van gedoseerde hoeveelheden vaste medicijnen
US10387620B1 (en) * 2015-10-19 2019-08-20 Exact Care Pharmacy, Llc Medication sorting and packaging system and method
US10558201B2 (en) 2016-09-09 2020-02-11 The Procter & Gamble Company System and method for producing products based upon demand
US10613523B2 (en) 2016-09-09 2020-04-07 The Procter & Gamble Company Methods for simultaneously producing different products on a single production line
US10643875B2 (en) 2016-09-09 2020-05-05 The Procter & Gamble Company System and method for simultaneously filling containers with different fluent compositions
US10640354B2 (en) 2016-09-09 2020-05-05 The Procter & Gamble Company System and method for simultaneously filling containers of different shapes and/or sizes
US10640249B2 (en) 2016-09-09 2020-05-05 The Procter & Gamble Company Track system for creating finished products
US11584628B2 (en) 2016-09-09 2023-02-21 The Procter & Gamble Company System and method for independently routing vehicles and delivering containers and closures to unit operation systems

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DE102017215917A1 (de) * 2017-09-08 2019-03-14 7 Ds Engeeniering Bv Individuelle Blisterverpackung, Verpackungsmaschine und Verfahren zur Herstellung einer individuellen Blisterverpackung
CN107738777B (zh) * 2017-09-11 2019-06-11 合肥通用机械研究院有限公司 一种生产线包装自动分配系统
CN108557131B (zh) * 2018-04-28 2020-05-05 中国人民解放军陆军军医大学第一附属医院 药物排列发放装置
KR20220161373A (ko) * 2020-04-01 2022-12-06 알엑스세이프 엘엘씨 약물용 자동 포장기
US11779518B2 (en) 2021-08-09 2023-10-10 Express Scripts Strategic Development, Inc. Blister pack device and method

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EP2754614B1 (de) 2015-06-24
WO2014108399A1 (de) 2014-07-17
EP2754614A1 (de) 2014-07-16
CA2897746A1 (en) 2014-07-17
CN105050899B (zh) 2017-06-30

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