US20140209642A1 - Unit for storing a fluid, and method for producing a unit for storing a fluid - Google Patents

Unit for storing a fluid, and method for producing a unit for storing a fluid Download PDF

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Publication number
US20140209642A1
US20140209642A1 US14/155,486 US201414155486A US2014209642A1 US 20140209642 A1 US20140209642 A1 US 20140209642A1 US 201414155486 A US201414155486 A US 201414155486A US 2014209642 A1 US2014209642 A1 US 2014209642A1
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US
United States
Prior art keywords
fluid
main body
channel
piston
closure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/155,486
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English (en)
Inventor
Ralf Schmied
Thomas Brinz
Gustav Klett
Holger Behrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Assigned to ROBERT BOSCH GMBH reassignment ROBERT BOSCH GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BEHRENS, HOLGER, KLETT, GUSTAV, BRINZ, THOMAS, SCHMIED, RALF
Publication of US20140209642A1 publication Critical patent/US20140209642A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0005—Containers or packages provided with a piston or with a movable bottom or partition having approximately the same section as the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/563—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
    • B01L3/5635—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors connecting two containers face to face, e.g. comprising a filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/02—Machines characterised by the incorporation of means for making the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber

Definitions

  • the present disclosure relates to a unit for storing a fluid, to a receiving device for receiving the unit for storing the fluid, to a system for providing the fluid, to a method for producing the unit, and to a method for providing the fluid.
  • DE 10 2009 045 685 A1 describes a microfluidic chip with a distensible diaphragm which is distensible into a liquid reservoir, with volume displacement, in order to move a liquid out of the liquid reservoir, through a liquid channel inlet and into a liquid channel of the microfluidic chip.
  • the present disclosure proposes a unit for storing a fluid, a receiving device for receiving the unit for storing the fluid, a system for providing the fluid, a method for producing the unit, and a method for providing the fluid, according to the description below.
  • Advantageous embodiments are set forth in the description below.
  • plastics may be permeable to some substances while being impermeable to other substances. If different substances are stored in an analysis unit that is made of plastic and has several directly adjoining chambers, it is possible for readily volatile substances to diffuse through the plastic and evaporate, or to contaminate other substances stored in adjoining chambers.
  • the reagents and auxiliary substances can be stored in prepared portions in anti-diffusion receptacles, and these receptacles can be opened in an automated manner just shortly before use, and the reagents and auxiliary substances are passed into an analysis area.
  • the reagents and auxiliary substances remain in the analysis area only for the duration of the analysis method. Thereafter, the whole analysis unit can be disposed of.
  • readily volatile reagents and auxiliary substances can be stored in anti-diffusion receptacles.
  • the anti-diffusion receptacles can be anti-diffusion units with an anti-diffusion closure, which units are opened in response to a switch-over command, such that the reagents and auxiliary substances can flow into the analysis area.
  • the units can be stored inside a receiving device.
  • a unit for storing a fluid, in particular a reagent or an auxiliary substance for a biochemical analysis method, wherein the unit has the following features:
  • a main body with a through-channel in which the fluid is arranged, wherein the main body is impermeable to the fluid and/or constituents of the fluid and is configured to be connected in a fluid-tight manner to a receiving device of a biochemical analysis unit, wherein the through-channel extends from a first end to a second end;
  • a piston which is mounted so as to be axially movable in the through-channel, wherein the piston is configured to provide a fluid-tight seal in relation to the main body, and/or the piston is impermeable to the fluid and constituents of the fluid and is accessible from the first end of the through-channel;
  • a closure which is arranged on the second end of the through-channel, wherein the closure is impermeable to the fluid and/or constituents of the fluid and is connected to the main body in a fluid-tight manner, wherein the closure is configured to burst when a pressure in the fluid is greater than a bursting pressure.
  • a receiving device for receiving a unit for storing a fluid according to the approach set out here, wherein the receiving device has the following feature:
  • the receiving opening for receiving the main body, wherein the receiving opening is configured as a through-channel from an outside of the receiving device to an inside of the receiving device, wherein the receiving opening is configured to provide a fluid-tight seal on an outer face of the main body when the main body is arranged in the receiving opening.
  • a system for providing a fluid for a biochemical analysis unit, having the following features:
  • a unit for storing a fluid according to the approach set out here wherein the main body is arranged in the receiving opening and the outer face of the main body is sealed off in a fluid-tight manner against the receiving opening, wherein the main body is connected or can be connected non-releasably to the receiving device, and the closure is arranged or can be arranged on the inside.
  • a method for producing a unit for providing a fluid wherein the method has the following steps:
  • a main body with a through-channel and of a piston which is mounted so as to be axially movable in the through-channel, wherein the fluid can be arranged in the through-channel, and the main body is impermeable to the fluid and constituents of the fluid and is configured to be connected in a fluid-tight manner to a receiving device of a biochemical analysis unit, wherein the through-channel extends from a first end to a second end, wherein the piston is configured to provide a fluid-tight seal in relation to the main body, and the piston is impermeable to the fluid and/or constituents of the fluid and is accessible from the first end of the through-channel;
  • a closure on the second end of the through-channel, wherein the closure is impermeable to the fluid and/or constituents of the fluid and is connected to the main body in a fluid-tight manner, wherein the closure is configured to burst when a pressure in the fluid is greater than a bursting pressure, in order to produce the unit for providing the fluid.
  • a method for providing a fluid for a biochemical analysis unit having the following steps:
  • a main body can be a hollow cylinder, for example.
  • a through-channel can be a bore or generally an opening in the main body.
  • the through-channel can extend rectilinearly, and with substantially a constant cross section, through the main body.
  • the through-channel can have an irregular cross section.
  • the main body can have a prismatic shape.
  • the through-channel can be a smaller image of a cross section of the main body.
  • the through-channel can also be shaped independently of the cross section of the main body.
  • the cross section of the main body can correspond externally to a polygon, while the through-channel is cylindrical.
  • the unit can be identified by the cross section of the main body, thus preventing the main body from being inserted into the wrong receiving device.
  • a piston standardized for use in differently shaped main bodies can be arranged in the inside of the unit, so as to be able to use the same parts in several different units.
  • the piston can have a seal for bearing sealingly on the main body.
  • the piston can be movable along the through-channel.
  • a cross-sectional area of the through-channel can vary from unit to unit, depending on what kind of fluid is arranged in the through-channel. The cross-sectional area may depend on the required amount of the fluid in the biochemical analysis method. The amount of the fluid can also be determined by a stroke length of the piston in the through-channel.
  • a closure can be a lid.
  • the closure can also be a cap or a flap.
  • the main body, the piston and the closure can be made from the same material.
  • the main body, the piston and the closure can also be made from different materials.
  • a connection site between the closure and the main body can break open, for example.
  • the closure itself can break open. The pressure can increase when the piston is pressed into the through-channel in the direction of the closure.
  • a receiving device can be an interface for receiving a unit.
  • the fluid can also be filled into several chambers inside the through-channel. Several different species can then be stored in a single through-channel and can be pressed out together by the piston. The species can be mixed while being pressed out.
  • the closure can be configured as an anti-diffusion film, which is welded to the main body.
  • the closure can have a predetermined breaking point.
  • the film can be a laminate of different types of plastics and/or metal film. To close it, at least one layer of the film can be fused to the main body.
  • a predetermined breaking point can be a predetermined area of weakening of the closure which, for example on account of a notch effect, only fails when the pressure is greater than the bursting pressure.
  • the closure can be configured to close when the pressure in the fluid is lower, by a tolerance pressure, than the bursting pressure.
  • the closure can close again in a fluid-tight manner when the piston remains in one position, for example because only a partial amount of the fluid is needed in the biochemical analysis.
  • the closure can apply restoring forces, which once again close the closure.
  • a length of the piston can be greater than or equal to a length of the through-channel.
  • the piston and the through-channel can form a press fit. If the piston is longer than or the same length as the main body, the piston can be pressed along the entire length of the through-channel without aids.
  • a press fit can be an interference fit. If the piston has a slightly larger cross section than the through-channel, the piston can then bear sealingly on the main body, without a further seal being necessary.
  • the piston can have, on a side facing toward the first end, an actuation surface which is oriented transversely with respect to a direction of movement of the piston.
  • the piston can have a depth stop, which is configured to limit a depth of penetration of the piston in the through-channel.
  • An actuation surface can be understood, for example, as a seat for a stamp for actuating the piston.
  • the area of the actuation surface available for actuating the piston can be greater than the cross-sectional area of the piston. In this way, the piston can be pressed down more easily.
  • the piston can have a thickened part at an end protruding from the main body.
  • a depth stop can be a functional surface on the piston, which functional surface abuts against another functional surface when the piston reaches its maximum planned depth of penetration.
  • the other functional surface can be arranged on the main body.
  • the other functional surface can also be arranged on the receiving device.
  • the main body can have at least one locking mechanism for connecting the main body non-releasably to the receiving device.
  • the main body can have at least one stop surface for limiting a depth of insertion of the main body into the receiving device.
  • the main body can have at least one manipulation surface for manipulation of the unit by a manipulating system.
  • a locking mechanism can be a detent lug, for example. In the latched state, the locking mechanism can no longer be reached manually or by means of an instrument, i.e. it can be concealed, such that the main body can no longer be removed from the receiving device.
  • the main body can also have an engagement surface for a locking mechanism of the receiving device. Receiving device and main body can engage one inside the other.
  • a stop surface can bear on another stop surface of the receiving device when the main body is arranged at an intended position.
  • a manipulation surface can be configured, for example, as a mating piece for a gripper. The unit can be held at the manipulation surface in an automated manner, for example in order to be transported for filling or to be inserted into the receiving device.
  • FIG. 1 shows a block diagram of a system for providing a fluid for a biochemical analysis unit according to an illustrative embodiment of the present disclosure
  • FIG. 2 shows a flow diagram of a method for producing a unit for providing a fluid according to an illustrative embodiment of the present disclosure
  • FIG. 3 shows a flow diagram of a method for providing a fluid for a biochemical analysis unit according to an illustrative embodiment of the present disclosure
  • FIG. 4 shows a sectional view of a detail from a system for providing a fluid for a biochemical analysis unit according to an illustrative embodiment of the present disclosure
  • FIG. 5 shows a view of a system for providing a fluid, with two units according to an illustrative embodiment of the present disclosure.
  • FIG. 1 shows a block diagram of a system 100 for providing a fluid 102 for a biochemical analysis unit according to an illustrative embodiment of the present disclosure.
  • the fluid 102 can be used in particular as a reagent or an auxiliary substance for a biochemical analysis method.
  • the fluid 102 can be alcohol or an alcohol mixture containing at least 75% alcohol.
  • the system 100 consists of a unit 104 , for storing the fluid 102 , and of a receiving device 106 .
  • the unit has a main body 108 , a piston 110 and a closure 112 .
  • the receiving device 106 has a receiving opening 114 , a supply chamber 116 , and a channel 118 leading to a biochemical analysis unit (not shown) for carrying out a biochemical analysis method.
  • the unit 104 for storing the fluid 102 has been inserted non-releasably into the receiving device 106 after the unit 104 has been produced.
  • the unit 104 and the receiving device 106 are connected to each other in a fluid-tight manner.
  • the main body 108 of the unit has a central through-channel 120 , in which the fluid 102 is arranged.
  • the main body 108 is made from a material that is impermeable to the fluid 102 and constituents of the fluid 102 .
  • the through-channel 120 extends from a first end to a second end of the main body 108 .
  • the piston 110 is mounted so as to be axially movable in the through-channel.
  • the piston 110 is sealed off in a fluid-tight manner in relation to the main body 108 .
  • the piston 110 is made from a material that is impermeable to the fluid and constituents of the fluid.
  • the piston 110 is accessible from the first end of the through-channel.
  • the closure 112 is arranged on the second end of the through-channel 120 .
  • the closure 112 is made from a material that is impermeable to the fluid and/or constituents of the fluid.
  • the closure 120 is connected to the main body 108 in a fluid-tight manner.
  • the closure 112 is configured to burst when a pressure in the fluid 102 is greater than a bursting pressure.
  • the receiving opening 114 is configured to receive the main body 108 .
  • the receiving opening 114 is configured as a through-channel from an outside of the receiving device 106 to an inside of the receiving device 106 .
  • the receiving opening 114 is configured to provide a fluid-tight seal on an outer face of the main body 108 when the main body 108 is arranged in the receiving opening 108 .
  • the unit 104 can be made from a material that prevents diffusion of solvents, in particular alcohol.
  • the material can be a polymer in particular.
  • solvent-containing, in particular alcohol-containing, fluids or liquids and/or pastes can be stored in the unit 104 permanently and without loss, until they are needed.
  • fluids that tend to denature can be protected in the unit against solvent vapors, in particular alcohol vapors.
  • the receiving device 106 can in turn be produced from an inexpensive and easily formable material, since the fluid and other fluids remain in the receiving device only for the duration of the biochemical analysis method, and there is not enough time for diffusion processes.
  • an advantageous plastic COC, PP, PE
  • steel can be used for the storage of alcohol as fluid.
  • the plastic of the syringe container 104 can be chosen independently of the plastic of the cartridge 106 .
  • the cartridge 106 can be configured using an inexpensive plastic with high alcohol permeation rates (e.g. PC).
  • the liquid 102 is always forced out by 100%, and there is no loss of expensive reagents in the LOC fluid network 116 , which leads to cost optimization of expensive PCR primers.
  • the liquid 102 can be provided in metered amounts, which leads to an improved process. Small amounts (a few ⁇ l) of liquids 102 can be stored in a stable state over a long period of time and can be provided 100% for the assay. This leads to a quality improvement in the course of the assay.
  • low-viscosity liquids 102 can be stored and safely forced out. Forcing them out by a volume displacement constitutes a flexible and robust system.
  • the syringes 104 can be used as additional reservoirs on the cartridge 100 during the process, as a result of which a reduction in the overall size is permitted.
  • liquids 102 can be mixed inside the syringe 104 , thereby permitting a further reduction in the overall size of the cartridge 100 .
  • FIG. 2 shows a flow diagram of a method 200 for producing a unit for providing a fluid according to an illustrative embodiment of the present disclosure.
  • the method 200 has a step 202 of providing, a step 204 of filling, and a step 206 of arranging.
  • a main body with a through-channel, and a piston which is mounted so as to be axially movable in the through-channel are provided.
  • the fluid can be arranged in the through-channel.
  • the main body is impermeable to the fluid and/or constituents of the fluid.
  • the main body is configured to be connected in a fluid-tight manner to a receiving device of a biochemical analysis unit.
  • the through-channel extends from a first end to a second end.
  • the piston is configured to provide a fluid-tight seal in relation to the main body and is impermeable to the fluid and constituents of the fluid.
  • the piston is accessible from the first end of the through-channel.
  • the through-channel is filled with the fluid from the second end.
  • a closure is arranged on the second end of the through-channel. The closure is impermeable to the fluid and constituents of the fluid and is connected to the main body in a fluid-tight manner, in order to produce the unit for providing the fluid.
  • the closure is configured to burst when a pressure in the fluid is greater than a bursting pressure.
  • FIG. 3 shows a flow diagram of a method 300 for providing a fluid for a biochemical analysis unit according to an illustrative embodiment of the present disclosure.
  • the method 300 has a step 302 of providing, and a step 304 of moving.
  • a system for providing according to the approach set out here is provided.
  • the piston is moved from the first end into the through-channel until the pressure in the fluid is greater than the bursting pressure, in order to provide the fluid at the second end of the through-channel on the inside.
  • FIG. 4 shows a sectional view of a detail of a system 100 for providing a fluid for a biochemical analysis unit according to an illustrative embodiment of the present disclosure.
  • FIG. 4 thus shows a cross section of a clipped-in syringe 104 in the cartridge 106 .
  • the system 100 corresponds to the system in FIG. 1 .
  • the piston 110 has a length that is greater than a length of the main body 108 . Therefore, in the filled state of the unit 104 as shown, the piston 110 protrudes with a free end above the main body 108 .
  • the piston 110 has an actuation surface 400 at the free end.
  • the actuation surface 400 is oriented transversely with respect to a direction of movement of the piston 110 .
  • the actuation surface 400 is many times greater than a cross-sectional surface of the piston 110 .
  • a movement of the piston 110 is made easier by the size of the actuation surface 400 .
  • a collar 402 is arranged on an edge of the actuation surface 400 .
  • the collar 402 is oriented transversely with respect to the actuation surface 400 and points in the direction of the receiving device 106 .
  • the collar 402 is configured extending peripherally about the actuation surface 400 .
  • a sectional plane of the piston 110 , of the actuation surface 400 and of the collar 402 has the shape of an upper-case letter T with serifs on the horizontal stroke.
  • the piston 110 represents the stem of the letter
  • the actuation surface 400 represents the horizontal stroke
  • the collar 402 represents the serifs.
  • the collar 402 is configured to act as a depth stop for the piston 110 .
  • the piston 110 can be pressed into the main body 108 until a stop surface 404 of the collar 402 bears on an outside of the receiving device 106 .
  • the main body 108 is configured as a hollow cylinder in this illustrative embodiment.
  • the main body has a locking mechanism 406 for connecting the main body 108 non-releasably to the receiving device 106 .
  • the locking mechanism 406 is configured as a plurality of springs 406 protruding from the main body 108 .
  • the springs 406 are each configured to be bent and to latch onto a projection 408 of the receiving device 106 .
  • the receiving device 106 has, in the area of the through-channel 114 , pockets 410 , which form the projections 408 .
  • a sealing face 412 is arranged, at which the unit 104 seals off the through-channel 114 in a fluid-tight manner when the unit 104 is connected to the receiving device 106 .
  • the springs 406 bear on that face of the pockets 410 directed toward the inside and thus represent the stop surface for limiting the depth of insertion of the main body 108 .
  • the through-channel 114 has widenings in order to make space available for the insertion of the springs 406 .
  • the springs 406 are arranged in the pockets 410 , they extend diagonally through the pockets 410 and prevent removal of the unit 104 from the receiving device 106 . As in FIG.
  • the through-channel in the main body 108 is covered by a film acting as a closure 112 .
  • the film is integrally bonded to the main body 108 .
  • the film can have a predetermined breaking point.
  • a partial area of a connection site between the closure 112 and the main body 108 can be configured to be weaker than the rest of the connection site, such that the closure fails in a controlled manner in the partial area.
  • the receiving device 106 does not have a supply chamber here.
  • the closure 112 is arranged directly in the channel 118 , while the main body 104 protrudes into the channel 118 .
  • FIG. 4 shows a cross-section of a clipped-in syringe 104 in the cartridge 106 .
  • These syringes 104 can be filled outside the cartridge 106 and are then sealed by an adhesive film 112 . All of the syringes 104 are clipped into the cartridge 106 during the production process, with alternative securing options also being possible, for example screwing or clamping.
  • the syringes 104 can be protected by a lid, as in FIG. 5 , against accidental actuation during transport.
  • the DxU presses on the piston 110 with a force F and thus actuates the syringe 104 .
  • a DxU can be understood as an evaluation device into which the cartridge is fitted and by which the cartridge is operated.
  • the evaluation unit also represents the interface to the user for displaying the results.
  • the amount of the reagent that is provided can be determined by the distance traveled and by a defined stop 404 in the cartridge 106 .
  • the volume of the syringe 104 can be varied by the diameter of the piston 110 .
  • no sealing elements are needed between DxU and cartridge 100 . The sealing elements are already integrated in the cartridge 106 and syringe 104 .
  • FIG. 5 shows a view of a system 100 for providing a fluid, with two units 104 according to an illustrative embodiment of the present disclosure.
  • the units 104 correspond to the unit in FIG. 4 .
  • Both units 104 are arranged alongside each other.
  • the units 104 are inserted into a common receiving device 106 and latched non-releasably.
  • the receiving device 106 has two through-holes arranged alongside each other.
  • the through-holes can open into a common mixing chamber in order to mix the fluids of both units 104 .
  • the through-holes can also each open into a respective supply chamber, so as to be able to be used separately for the biochemical analysis method.
  • the actuation surfaces 400 are covered by a protective cap 500 .
  • the protective cap 500 is secured on the receiving device 106 and is intended to be removed before the system 100 is used, such that the actuation surfaces are exposed.
  • the protective cap 500 also protects the units 104 from environmental effects, in particular contamination. In this way, an analysis appliance can be kept clean when the analysis unit, with the providing system 100 secured thereon, is inserted.
  • FIG. 5 shows a lab-on-a-chip (LOC) cartridge 100 with integrated syringes 104 for storing reagents.
  • LOC lab-on-a-chip
  • ⁇ TAS microfluidic platforms
  • the lab-on-a-chip platforms can be constructed as so-called cartridges which, as disposable articles, receive and process the patient sample. Liquids are needed for the process carried out on the cartridge, which liquids can either be stored on the cartridge or can subsequently be added for the process by a user.
  • the subsequent introduction of the reagents, even of alcohol-containing substances, can be avoided by the approach set out here, since this is provided just shortly before the assay is performed. Thus, the high permeation rates of the alcohol in favorable plastics is unimportant.
  • the approach set out here allows all the reagents of a lab-on-a-chip assay to be stored in a stable state over a long period of time on the cartridge 100 .
  • reagents containing alcohol or reagents in small amounts can be safely stored inside the LOC cartridge 100 .
  • the illustrated system 100 makes storage safe during transport, and it permits simple opening and provision of the reagents in the case of use. All the pistons of the syringes 104 of a cartridge 106 can be connected by a beam, which is pressed down by the DxU and thus empties the syringes 104 simultaneously.
  • an illustrative embodiment comprises an “and/or” link between a first feature and a second feature
  • this is to be understood as meaning that the illustrative embodiment, in one form, has both the first feature and also the second feature and, in another form, has either only the first feature or only the second feature.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
US14/155,486 2013-01-28 2014-01-15 Unit for storing a fluid, and method for producing a unit for storing a fluid Abandoned US20140209642A1 (en)

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DE102013201297.7 2013-01-28
DE102013201297.7A DE102013201297A1 (de) 2013-01-28 2013-01-28 Einheit zum Bevorraten eines Fluids und Verfahren zur Herstellung einer Einheit zum Bevorraten eines Fluids

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DE102009045685A1 (de) 2009-10-14 2011-04-21 Robert Bosch Gmbh Mikrofluidischer Chip
US8752732B2 (en) * 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system

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Publication number Priority date Publication date Assignee Title
US2665690A (en) * 1950-09-29 1954-01-12 Compule Corp Plural-compartment admixing container or vial
US3537605A (en) * 1969-01-13 1970-11-03 Ida Solowey Compartmented containers having a rupturable diaphragm between compartments
US3809225A (en) * 1969-05-02 1974-05-07 Goupil J Containers
US3731853A (en) * 1969-08-01 1973-05-08 G Beham Multi-chamber receptacle
US3785481A (en) * 1970-08-12 1974-01-15 Goupil J Multi-chamber container
US3860114A (en) * 1970-11-04 1975-01-14 Volker Merckardt Multi-chamber container
US3894845A (en) * 1973-05-24 1975-07-15 Bernard Mcdonald Urine collection and analysis device
US5392904A (en) * 1993-05-12 1995-02-28 Firma Ivoclar Ag Mixing capsule for dental compositions
US5509530A (en) * 1995-07-20 1996-04-23 Wykle Research, Inc. Compartmentalized dental amalgam mixing capsule
US6360886B1 (en) * 2000-03-13 2002-03-26 Kerr Corporation Capsule for use in preparing a dental amalgam
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DE102013201297A1 (de) 2014-07-31

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