US20140031802A1 - Guided cardiac ablation catheters - Google Patents
Guided cardiac ablation catheters Download PDFInfo
- Publication number
- US20140031802A1 US20140031802A1 US13/952,013 US201313952013A US2014031802A1 US 20140031802 A1 US20140031802 A1 US 20140031802A1 US 201313952013 A US201313952013 A US 201313952013A US 2014031802 A1 US2014031802 A1 US 2014031802A1
- Authority
- US
- United States
- Prior art keywords
- instrument
- ablation
- endoscope
- balloon
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00043—Operational features of endoscopes provided with output arrangements
- A61B1/00045—Display arrangement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00131—Accessories for endoscopes
- A61B1/00135—Oversleeves mounted on the endoscope prior to insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00195—Optical arrangements with eyepieces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/313—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
- A61B1/3137—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes for examination of the interior of blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1482—Probes or electrodes therefor having a long rigid shaft for accessing the inner body transcutaneously in minimal invasive surgery, e.g. laparoscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
- A61N7/022—Localised ultrasound hyperthermia intracavitary
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
- A61B2018/0022—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00375—Ostium, e.g. ostium of pulmonary vein or artery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2255—Optical elements at the distal end of probe tips
- A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/06—Measuring instruments not otherwise provided for
- A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
- A61B2090/065—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension for measuring contact or contact pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3966—Radiopaque markers visible in an X-ray image
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
- A61N2005/1003—Intraluminal radiation therapy having means for centering a radioactive source within the lumen, e.g. balloons
Abstract
Description
- The present application is a continuation of U.S. patent application Ser. No. 10/865,558, filed Jun. 10, 2004, which claims priority of U.S. Provisional Patent Application Ser. No. 60/477,374; filed Jun. 10, 2003, and is a continuation-in part of U.S. patent application Ser. No. 10/317,156, filed Feb. 3, 2003, which is a continuation-in-part of U.S. patent application Ser. No. 09/924,393; filed on Aug. 7, 2001. U.S. patent application Ser. No. 10/865,558 is also a continuation-in-part of U.S. patent application Ser. No. 10/674,114; filed Sep. 29, 2003, which is a continuation of U.S. patent application Ser. No. 09/616,275 filed Jul. 14, 2000, now U.S. Pat. No. 6,626,900. U.S. patent application Ser. No. 09/616,275 is also a continuation-in-part of U.S. patent application Ser. No. 09/602,420 filed Jun. 23, 2000; now U.S. Pat. No. 6,572,609, which is a continuation-in-part of U.S. patent application Ser. No. 09/357,355; filed on Jul. 14, 1999; now U.S. Pat. No. 6,423,055 issued Jul. 22, 2002. The teachings of all of these prior related applications are hereby expressly incorporated by reference.
- The present invention relates to ablation instruments for the treatment of atrial fibrillation and, in particular, to percutaneous instruments employing energy emitters for the ablation of tissue surrounding the pulmonary veins. Methods of ablating tissue to treat atrial fibrillation using radiant energy are also disclosed.
- Atrial fibrillation is the most common cardiac arrhythmia and affects approximately 2.3 million people in the United States. It is characterized by rapid randomized contractions of atrial myocardium, causing an irregular, often rapid ventricular rate. The regular pumping function of the atria is replaced by a disorganized; ineffective quivering as a result of chaotic conduction of electrical signals through the upper chambers of the heart. Weakness, lightheadedness, fainting, heart failure, stroke and even death can result.
- In 1991, Dr. James Cox developed a surgical procedure, called the Maze Procedure, to cure atrial fibrillation, It involved cutting the atrial wall into many pieces in an intricate pattern and sewing them back together. The scar tissue that formed blocked the conduction of electrical impulses and caused them to follow a pre-arranged pattern. Although this procedure was successful in curing atrial fibrillation, the difficulty of the procedure, its invasive nature and the morbidity involved prevented its widespread adoption.
- Prior to the late 1990's it was believed that less invasive procedures and associated devices to cure atrial fibrillation would have to mimic the Maze procedure and create long lines of conduction block in the atrial wall. Several types of ablation devices were proposed which utilized some form of energy, generally radio-frequency (“RF”) heating to create elongated lesions that extend through a sufficient thickness of the myocardium to block electrical conduction. Many of the proposed ablation instruments are percutaneous devices that are designed to create such lesions from within the heart. Such devices are positioned in the heart by catheterization of the patient, e.g., by passing the ablation instrument into the heart via a blood vessel, such as the femoral vein. See, for example, U.S. Pat. No. 5,575,766 issued to Swartz, which discloses the use of ablation electrodes introduced into the heart via a catheter to create Maze-like lesions and U.S. Pat. No. 5,904,651 issued to Swanson, which discloses a similar electrical ablation device with an imaging element to create Maze-like lesions under visual control. However, because of the difficulty in creating long lesions that were correctly located, continuous and transmural (through the heart wall) these devices have not achieved clinical or commercial success.
- In 1997 and 1998 two seminal papers by Drs. Jais and Hassaguerre identified the pulmonary veins as the primary origin of errant electrical signals responsible for triggering atrial fibrillation. By ablating the heart tissue at selected locations in or surrounding the pulmonary veins, electrical impulses from such foci of fibrillation can be blocked. In one known approach, circumferential ablation of tissue within the pulmonary veins, at the ostia (mouth) of such veins or outside of the veins has been practiced to treat atrial fibrillation. Similarly, ablation of the region surrounding the pulmonary veins as a group has also been proposed.
- Several types of catheter ablation devices have recently been proposed for creating circumferential lesions to treat atrial fibrillation, including devices which employ radiofrequency, microwave or ultrasonic energy or cryogenic cooling. Regardless of the type of ablation instrument used, the desired result is a continuous circumferential lesion that isolates the foci that trigger fibrillation from the atrial tissue. Post-ablation electrical mapping is usually necessary to determine whether a circumferential lesion has been formed. If electrical conduction is still present, the encircling lesion is incomplete and the procedure must be repeated or abandoned.
- Generally for the ablation instrument to be effective a clear transmission pathway is desired, e.g., a pathway from which blood has been substantially cleared. If there is too much blood between the ablation element and the target tissue, the ablation energy will be attenuated and the lesion will not be continuous and block electrical conduction.
- One way to limit the amount of blood between the ablation element and the tissue is to force the ablation instrument deeper in the vein. However, if the energy application is too deep in the vein, it can result in damage to the vein and resultant narrowing of the vein, called pulmonary vein stenosis, which has serious consequences and can be life threatening.
- The correct positioning of the ablation device in the heart to obtain complete lesions that will provide conduction block without damaging sensitive tissues is complicated by the fact that the standard imaging technique available to the physician for the procedure is x-ray fluoroscopy which does a poor job of imaging soft tissues such as the heart and pulmonary veins. X-ray contrast injection can be used to aid in imaging smaller arteries such as the coronary arteries but such injection is of very limited use when the entire heart or vessels as large as the pulmonary veins need to be imaged. As a result, the physician using these ablation catheters has limited ability to understand the detailed anatomy of the vein and to understand how the ablation catheter is positioned in that anatomy.
- Existing instruments for cardiac ablation suffer from a variety of design limitations. In one common approach, described, for example, in U.S. Pat. No. 6,012,457 issued to Lesh on Jan. 11, 2000 and in International Application Pub. No. WO 00/67656 assigned to Atrionix, Inc, a guide wire or similar guide device is advanced through the left atrium of the heart and into a pulmonary vein. A catheter instrument with an expandable element is then advanced over the guide and into the pulmonary vein where the expandable element (e.g., a balloon) is inflated.
- The balloon structure also includes a circumferential ablation element, e.g., an RF electrode carried on the outer surface of the balloon, which performs the ablation procedure. In order for the electrode to be effective, it must in contact with the tissue throughout the procedure. In such devices, a major limitation in prior art percutaneous designs is their inability to maintain such contact with the actual and quite varied geometry of the heart. The inner surface of the atrium is not regular. In particular, the mouths of the pulmonary veins do not exhibit regularity; they often bear little resemblance to conical or funnel-shaped openings. When the expandable, contact heating devices of the prior art encounter irregularly-shaped ostia, the result can be an incompletely formed (non-circumferential) lesion. This limitation is also present in the case of cryogenic balloon catheters where contact with the target tissue is required in order to perform the desire lesion.
- Another problem commonly encountered in maneuvering an instrument within the left atrium is the need to detect side branches in the pulmonary veins. If the energy is delivered into a side branch a lesion will not be formed at that location and a circumferential lesion will not be formed. A related problem is that it is often difficult to distinguish between blood at the target site, which can sometimes be remedied by reseating of the instrument, and the presence of a vessel side branch, which will preclude formation of a continuous lesion regardless of attempts to reseat at the location. This problem is underscored by a study by Saliba et al., Journal of Cardiovascular Electrophysiology, Vol. 13, No. 10, pp. 957-961 Oct. 12, 2002, in which the authors report a success rate of only 39% in treating atrial fibrillation in 33 patients using a circumferential ultrasound ablation device. Among the causes for failure of the device suggested by the authors were eccentric balloon placement in the pulmonary vein and inability to detect early branching of the vein which would result in ineffective circumferential energy delivery.
- Another limitation in the prior art percutaneous designs is the lack of site selectability. Practically speaking, each prior art percutaneous instrument is inherently limited by its design to forming an ablative lesion at one and only one location. For example, when an expandable balloon carrying an RF heating surface on it surface is deployed at the mouth of a vein, the lesion can only be formed at a location defined by the geometry of the device. It is not possible to form the lesion at another location because the heating element must contact the target tissue. If the ablation element is not in contact with tissue at some location the entire catheter must be repositioned in an attempt to obtain contact. Often it is not possible to find a single position where contact is obtained completely around the vein.
- U.S. Pat. No. 6,514,249 issued to Maguire et al. on Feb. 4, 2003 discloses one approach to positioning an ablation element within a pulmonary vein ostium. This patent describes the use of ultrasound, pressure or temperature sensors to determine if the instrument is in contact with a target region of tissue. While such sensors can be useful in determining contact at a particular location, the devices disclosed by U.S. Pat. No. 6,514,249 can not provide an image of the anatomy of the vein, the location of side branches or the position of the instrument relative to the target site in a manner that would allow a clinician to devise an optimal ablation plan.
- Accordingly, there is a need for better ablation instruments that can form lesions with less trauma to the healthy tissue of the heart and provide a greater likelihood of successfully producing fully circumferential lesions. A percutaneous system that can aid in visualizing the anatomy of the vein, in determining the location of side branches, in visualizing the position of the catheter relative to the vein and any side branches, in determining whether contact has been achieved (or blood has been cleared from an ablative energy transmission path) before ablation, and in determining the optimum location for energy delivery would improve the likelihood of first-time success based on such determinations and would represent a significant improvement over the existing designs.
- Moreover, a percutaneous ablation device that allowed the clinician to select the location of the ablation site based upon such visualization would be highly desirable. One such device is described in commonly-owned, parent applications, e.g., U.S. patent application Ser. No. 10/357,156, filed Feb. 3, 2003 and Ser. No. 09/924,393, filed on Aug. 7, 2001, which disclose a balloon ablation device having an energy emitting element and an optical sensor. The energy emitting element is independently positionable within the lumen of the instrument and adapted to project ablative energy through a transmissive region of a balloon to a target tissue site.
- Because the position of the radiant energy emitter can be varied, the clinician can select the location of the desired lesion without the necessity of repositioning the instrument. Applicants' basic devices, as described in the prior filings, thus, allow a clinician to choose from a number of different lesion locations and, if desired, also permit the formation of composite lesions that combine to form continuous conduction blocks around pulmonary veins or other cardiac structures.
- However, even Applicants' advanced ablation devices could benefit from enhanced visualization of the cardiac anatomy. Similarly, any sophisticated cardiac ablation device could likewise benefit from visual data in instrument positioning, identifying targets, and/or monitoring the progress of ablative procedures as well as selecting an optimal dose based on the location to be treated.
- Guided ablation instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias and the like. In one aspect of the invention, a percutaneous catheter is disclosed with an endoscope positionable in the instrument's distal end region to obtain an image. The image allows the clinician to visualize the anatomy of the vein, the location of side branches and the position of the instrument relative to the vein. The clinician can determine whether contact has been achieved (or blood has been cleared from an ablative energy transmission path) and the optimum location for ablation or radiation dosing before ablation begins or while ablation is occurring.
- In one embodiment, percutaneous ablation catheters are disclosed having at least one central lumen and one or more balloon structures at the distal end region of the instrument. Also disposed in the distal end region is an illuminating light source and an endoscope capable of collecting sufficient light to relay an image to the user. The instruments can further include an energy emitting element, which is preferably independently positionable within the lumen of the instrument (e.g., along a longitudinal axis of the balloon) and adapted to project ablative energy through a transmissive region of the instrument body (and/or balloon) to a target tissue site. The energy can be delivered without the need for contact between the energy emitter and the target tissue so long as a clear transmission pathway is established. The endoscope element of the instrument allows the clinician to see if such a pathway is clear.
- Moreover, when the position of the radiant energy emitter can be varied, endoscopic guidance permits the clinician to select a desired location and dose for the lesion. Endoscopic inspection thus permits the clinician to define a priori an “ablation plan” before performing ablation. Based on the location and size of the lesion, the present inventions permits the user to select a suitable energy level, e.g., to compensate for the power changes due to the size of the lesion and/or to compensate for the amount of attenuation caused by projecting energy to a target site across a greater distance.
- In another aspect of the invention, generally applicable to a wide range of cardiac ablation instruments, mechanisms are disclosed for determining whether the instrument has been properly seated within the heart, e.g., whether the device is in contact with a pulmonary vein and/or the atrial surface, in order to form a lesion by heating, cooling or projecting energy. The projected energy can be focused by either refractive or reflective elements. This contact-sensing feature can be implemented by an illumination source and an endoscope situated within the instrument. The image captured by the endoscope from the reflected light can be used to determine whether contact has been achieved and whether such contact is continuous over a desired ablation path. The image data can also be enhanced by selective wavelength capture, optical filtering, or other image data processing techniques.
- Monitoring allows the clinician to observe balloon inflation and establish an optimal size (with sufficient contact for ablation). Reflective monitoring and/or imaging, especially with wide field of view optics, can be used to determine if the instrument is too deep within a pulmonary vein by mapping tissue contact on the balloon. For example, tissue contact with proximal (rear) portions of the balloon can indicate over-insertion of the balloon in to a vein. Because the device has a wide angle field of view and a large depth of field the clinician can also see the relationship of the balloon to the pulmonary vein ostia. This capability allows the clinician to determine if the balloon is too deep in the pulmonary vein because the optical sensor has the ability to see a large portion of the interior the balloon. Any tissue contact determined to be proximal to the apex (widest segment) of the balloon would indicate that the instrument is too deep in the vein and has the possibility of causing pulmonary vein stenosis.
- In addition, because inflation of the balloon can be observed under direct visualization, the clinician can determine it the balloon is stretching the vein radially by assessing if full contact is achieved before the balloon is completely inflated. This stretching condition would also indicate that the balloon is too distal in the pulmonary vein and could cause damage.
- In order to determine if there is tissue contact with the proximal portion of the balloon, the endoscope needs to have a wide field of view. In one preferred embodiment, the endoscope can have a field of view greater than about 70 degrees, preferably greater than 90 degrees. In addition, to see the back of the balloon, as well as the front of the balloon, the endoscope can be placed in the back of the balloon as well as possess a long depth of field. The endoscope's depth of field can be greater than 13 mm, preferably greater than 25 mm, and more preferably, in some applications, greater than 35 mm. The f-number of the endoscope can be less than 4, preferably less than 3 and more preferably less than 2.5.
- When used in conjunction with a radiant energy emitter, the endoscope and ablation element can be introduced as an assembly. In such configurations, the energy emitter can also serve as the illumination source by operating at a low power level to provide the light for image acquisition. Alternatively, either the endoscope or the ablative element (or both) can be independently positionable within the instrument.
- Endoscopic guidance has several advantages over conventional guidance or location systems. For example, fluoroscopic location techniques offer at best a two-dimensional view of a percutaneous cardiac instrument vis-a-vis heart structures. Such two-dimensional views can be deceiving and the fluoroscopic images of veins during dye injection are transient, at best. In addition, contrast medium flowing through a vein can not reliably detect side branches or permit imaging of the heart itself Moreover, fluoroscopic images are ill-suited for determining whether a balloon structure has been seated in contact with a tissue structure, e.g., a pulmonary vein ostium. Ultrasound images are likewise limited in their ability to ascertain tissue contact. The endoscopic guidance apparatus and methods of the present invention readily permit instruction location with a high degree of accuracy and also provide a simple, well defined measurement of the degree of circumferential contact between an instrument e.g., a projection balloon surface and target tissue. In one embodiment, the endoscope can be in a fixed position relative to the projection balloon.
- In addition to determining the degree of contact between the instrument and the tissue, the endoscope can be used to determine the extent of tissue ablation by sensing the change in color of the tissue as it is ablated. Moreover, the endoscope can be used to detect the formation of potentially dangerous coagulated blood at the site of ablation and to allow the clinician to terminate the ablation if necessary for safety reasons. The endoscopic image can also be used to extract colorimetric data, e.g., to distinguish between tissue and blood.
- In a further embodiment of the invention, a cardiac ablation instrument is disclosed having an elongate catheter body with a distal portion adapted for disposition within a heart. This catheter body has at least one lumen therein and an expandable, energy-transmitting element which can be deployed at the desired location with or without an anchorage element to contact a cardiac structure and establish a transmission pathway. For example, the expandable element can be a projection balloon that is expandable to fill the space between the energy emitter and the target tissue with an energy-transmissive fluid and, thereby, provide a transmission pathway for projected radiant energy. The balloon can further be used to collapse trabecular tissue and, thereby, define a focal region into which a uniform dose of ablative energy can be projected or reflected. More generally, the balloon can be used to smooth irregular tissue surfaces and/or define focal planes or curved focal surfaces for the delivery of ablative energy to cardiac tissue in contact with such surfaces. The instrument can further include a radiant energy delivery element movable within the lumen of the catheter body such that it can be disposed at the desired location and deliver radiant energy through a transmissive region of the instrument to a target tissue site. The movable energy emitter thus permits multi-step treatments, e.g., encircling an asymmetric vein structure with a series of arc-shaped lesions, without the need for repositioning of the balloon or any other portion of the instrument. The instrument can further include additional elements, such fluid delivery ports, to provide a blood-free transmission pathway from the energy emitter to the tissue target. In accordance with the invention, an endoscope is disposed within the projection balloon to monitor and/or guide instrument placement.
- Mechanisms are disclosed for determining whether the ablation instruments of the present invention have been properly seated within the heart to form a lesion. For example, if a projection balloon is employed to provide a clear transmission pathway from a radiant energy emitter to the target tissue, the mechanisms of the present invention can sense by endoscopic imaging whether contact has been achieved between the balloon and the target tissue (and/or whether the pathway for projection of radiant energy has been otherwise cleared of blood). In one embodiment, this contact-sensing feature can be implemented by an illumination fiber situated within the instrument and an imaging fiber assembly that collects reflected light. Images obtained by capture of reflected light (or particular wavelengths of the reflected light) can this be used to determine whether contact has been achieved between the projection balloon and the target tissue, whether blood has been cleared from any gaps and whether a clear and continuous transmission pathway has been established over a desired ablation path.
- In a further aspect of the invention, percutaneous instruments are disclosed that can achieve rapid and effective coagulation or ablation through the use of tissue-penetrating radiant energy. It has been discovered that radiant energy, e.g., projected electromagnetic radiation or ultrasound, can create lesions in less time and with less risk of the adverse types of surface tissue destruction commonly associated with prior art approaches. Unlike instruments that rely on thermal conduction or resistive heating, controlled penetrating radiant energy can be used to simultaneously deposit energy throughout the full thickness of a target tissue, such as a heart wall. Radiant energy can also produce better defined and more uniform lesions. The extent of lesion formation can also be monitored in real-time by the endoscopic imaging and used in a feedback control mode to control the duration of ablation and/or induce modifications of the ablation protocol to achieve a desired or optimized result.
- The use of radiant energy, in conjunction with catheter structures that are substantially transparent to such radiation at the therapeutic wavelengths, is particularly advantageous in affording greater freedom in selecting the location of the lesion, e.g., the site is no longer limited to the pulmonary vein itself. Because the energy can be projected onto the tissue, a ring-like lesion can be formed in atrial tissue at a distance from the vein, thereby reducing the potential for stenosis and/or other damage to the vein itself. Endoscopic-guidance allows the clinician to select a desired lesion location and implement a desired ablation plan by appropriate placement of the radiant energy emitter.
- In certain embodiments, infrared radiation is particularly useful in forming photoablative lesions. In certain preferred embodiments, the instruments emit radiation at a wavelength in a range from about 800 nm to about 1000 nm, and preferably emit at a wavelength in a range of about 915 nm to about 980 nm. Radiation at a wavelength of 915 nm or 980 nm is commonly preferred, in some applications, because of the optimal absorption of infrared radiation by cardiac tissue at these wavelengths. Such infrared radiation can also be useful as illumination light for the endoscope when provided at a sufficiently low power to capture images without untoward damage to the image capture elements of the invention. Alternatively, ablation can be performed with infrared radiation while one or more white light sources can serve as the illumination component.
- In another embodiment, focused ultrasound energy can be used to ablate cardiac tissue. In certain preferred embodiments, an ultrasound transducer can be employed to transmit frequencies within the range of about 5 to about 20 MHz, and preferably in some applications within the range of about 7 MHz to about 10 MHz. In addition, the ultrasonic emitter can include focusing and/or reflective elements to shape the emitted energy into an annular beam or other desired shape.
- However, in certain applications, other forms of radiant energy can also be useful including, but not limited to, other wavelengths of light, other frequencies of ultrasound, x-rays, gamma-rays, microwave radiation and hypersound.
- In the case of radiant light, the energy delivering element can include a light transmitting optical fiber adapted to receive ablative radiation from a radiation source and a light emitting tip at a distal end of the fiber for emitting radiation. The light delivering element can be slidably disposed within an inner lumen of the catheter body and the instrument can further include a translatory mechanism for disposing the tip of the light delivering element at one or more of a plurality of locations with the catheter. Moreover, by moving the energy-projecting tip assembly within the catheter, the diameter of the projected ring or arc of energy can be readily varied, thereby permitting the clinician control over the location (and size) of the lesion to be formed. Endoscopic guidance not only permits determinations of location but also the extent of tissue contact in such systems and facilitates accurate dosimetry calculations for lesions of variable size.
- The present invention provides mechanisms for visualizing where the energy will be applied prior to treatment. In one embodiment, the energy delivering element can include an aiming light source to project visible light onto the tissue, and reflected light can be observed via the endoscope. This visible light from the aiming beam provides an indication to the clinician of the exact location of energy delivery. Markers on the balloon are also disclosed for such visualization based on known correlations between the variable position of the energy source and particular regions of the balloon. In another embodiment, virtual markers are employed. Based on such visual data, the location of ablation element can be selected to optimize the lesion formed upon activation of the ablation element.
- Optionally, a fluid can be disposable between the radiant energy delivery element and the target region. In one preferred embodiment a “projection balloon” is filled with a radiation-transmissive fluid so that radiant energy from the energy emitter can be efficiently passed through the instrument to the target region. The fluid can also be used to cool the energy emitter through conduction or via a closed or open circulator system. In certain applications, it can be desirable to used deuterium oxide (so-called “heavy water”) as a balloon-filling fluid medium because of its loss absorption characteristics vis-a-vis infrared radiation. In other applications, the inflation fluid can be water or saline or an admixture of such fluids with deuterium oxide (to enhance ablative energy transmission) and/or sodium diatrazoate (to enhance radiographic imaging).
- It can also be desirable to employ an “ablative fluid” outside of the instrument (e.g., between the balloon and the target region) to ensure efficient transmission of the radiant energy when the instrument is deployed. An “ablative fluid” in this context is any fluid that can serve as a conductor of the radiant energy. This fluid can be a physiologically compatible fluid, such as saline, or any other non-toxic aqueous fluid that is substantially transparent to the radiation.
- In one preferred embodiment, the fluid is released via one or more exit ports in the housing and flows between the projection balloon and the surrounding tissue, thereby filling any gaps where the balloon does not contact the tissue. The fluid can also serve an irrigation function by displacing any blood within the path of the radiant energy, which could otherwise interfere because of the highly absorptive nature of blood with respect to radiant light energy.
- Similarly, if the radiant energy is acoustic, aqueous coupling fluids can be used to ensure high transmission of the energy to the tissue (and likewise displace blood that might interfere with the radiant acoustic energy transfer).
- The ablative fluids of the present invention can also include various other adjuvants, including, for example, photosensitizing agents and/or pharmacological agents.
- As noted above, sensing mechanisms are also disclosed to assist the clinician in selecting the location of the lesion and in ensuring a selected location will result in the formation of a continuous (e.g., vein encircling) lesion. In one embodiment, the sensor employs a plurality of light-transmitting fibers, e.g., an endoscope, to determine whether or not a clear transmission pathway has been established (e.g., whether the projection balloon is properly seated and any gaps in contact have been filled by an ablative fluid).
- In another aspect of the invention, methods are disclosed for selecting a site for cardiac tissue ablation by positioning a guide wire in a pulmonary vein; and passing a catheter with an endoscope over the guide wire such that it can be disposed in proximity to the vein; and determining whether the catheter is located in a desired location based on an image captured by the endoscope.
- More generally, the methods of the present invention can be practiced with or without guidewires. In one embodiment, a guidewire can be used and a catheter with an affixed endoscope can be passed over the guide wire to monitor the placement of a fixed or maneuverable ablation element, thereby permitting a clinician to monitor placement of the catheter and/or ablation element. Alternatively, a guide wire can be used and the catheter passed over the guidewire, followed by the introduction of an endoscope via a lumen or other guide element on or within the catheter, such that the endoscope can confirm the catheter position and/or observe the placement of one or more ablation elements (which can be either fixed to the catheter or independently positionable vis-a-vis a target site).
- In yet another method of the invention, the endoscope can be used without a guidewire as a means for monitoring the placement of an ablation device within the heart and/or the positioning of an ablation element, which can be either an integral part of a catheter or independently positionable relative to a catheter.
- Most generally, the methods of the present invention encompass the use of endoscopes to determine whether an ablation device is properly located prior to the commencement of an ablation procedure, regardless of the type of ablative element, the type of catheter instrument or the use or non-use of a guidewire. The methods of the present invention further encompass the use of an endoscope to select a desired site, maneuver the instrument to a desired ablation path and monitor ablation as it is carried out.
- The inspection methods of the present invention can be used, for example, to determine whether a clear transmission path can be established between an energy emitter and a target tissue site based on imagery captured by the endoscope disposed within the lumen of the catheter. The methods can also be used to determine whether a continuous linear or curvilinear lesion can be formed along a desired path at a target tissue site based on the endoscopic images. Moreover, the methods can be used to also determine whether a continuous circumferential lesion can be formed to surround a target region of the heart, such as one or more pulmonary veins, based on imagery captured by the endoscope disposed within the lumen of the catheter.
- The present invention also provides methods for ablating tissue around one or more of the pulmonary veins. One method of ablating tissue comprises positioning a radiant energy emitting element at a distance from a target region of tissue in proximity to the pulmonary vein, providing a blood-free transmission pathway between the emitter and the target region, and then projecting radiant energy to expose the target region and induce a lesion.
- In one method according to the invention, a guide wire is first inserted into the femoral vein and advanced through the inferior vena cava, and into the right atrium, and then guided into the left atrium via an atrial septal puncture. The guide wire is advanced until it enters a pulmonary vein. A catheter body is then slid over the guide wire until it is likewise advanced into, or seated proximal to, the pulmonary vein. A projection balloon is then inflated via an inflation fluid to define a transmission pathway to a target tissue site. In addition, a solution can be injected through the instrument to force blood and/or body fluids away from the treatment site.
- The guide wire is then removed and replaced with a radiant energy emitter, which is positioned to deliver radiant energy through the projection balloon to induce tissue ablation. The methods of the present invention can further include a position sensing step to assist the clinician in selecting the location of the lesion and in ensuring a selected location will result in the formation of a continuous (e.g., vein encircling) lesion. Either in conjunction with the ablation element, or before deployment of the ablation element, an endoscope is disposed with the instrument to determine whether a clear transmission pathway has been established (e.g., whether the expandable element is properly seated and any gaps in contact have been filled by an ablative fluid).
- The invention will be more fully understood from the following detailed description taken in conjunction with the accompanying drawings, in which like reference numerals designate like parts throughout the figures, and wherein:
-
FIG. 1 is a schematic view of an endoscope-guided cardiac ablation instrument according to the invention; -
FIG. 1A is a schematic view of an endoscope/ablation element assembly according to the invention; -
FIG. 2 is a schematic illustration of an initial step in performing ablative surgery according to the invention, in which a guide wire is introduced into a heart and passed into a pulmonary vein; -
FIG. 3A is a schematic illustration of a further step in performing ablative surgery according to the invention, in which a catheter carrying a projection balloon structure is slid over a guide wire; -
FIG. 3B is a schematic illustration of a further step in performing ablative surgery with the embodiment illustrated inFIG. 3A , in which the projection balloon element is inflated to define a projection pathway for radiant energy ablation of cardiac tissue; -
FIG. 4 is a schematic illustration of a further step in performing ablative surgery with the embodiment illustrated inFIGS. 3A-3B , in which the guide wire is removed and replaced by a radiant energy emitter located remote from the lesion site but in a position that permits projection of radiant energy onto a target region of the heart in which an asymmetric vein mouth is encountered and further showing how the position of the radiant energy emitter can be adjusted to select a desired location; -
FIG. 5 illustrates how a continuous, vein-encircling lesion can be formed by two partially-encircling lesions; -
FIG. 6 is a schematic block diagram of the components of an endoscope-guided cardiac ablation system according to the invention; -
FIG. 7 is a schematic illustration of one embodiment of a radiant light energy emitter according to the invention; -
FIG. 8 is a schematic illustration of another embodiment of a radiant light energy emitter according to the invention; -
FIG. 9 is a schematic illustration of an alternative embodiment of a radiant energy emitter according to the invention employing ultrasound energy; -
FIG. 10 is a schematic illustration of an alternative embodiment of a radiant light energy emitter according to the invention employing microwave or ionizing radiation; -
FIG. 11 is a schematic cross-sectional illustration of one embodiment of endoscope and ablator assembly according to the invention; -
FIG. 11A is a more detailed schematic cross-sectional view of an endoscope according to the invention; -
FIG. 12 is an end view, schematic illustration of the endoscope and ablator assembly shown inFIG. 11 ; -
FIG. 13 is a schematic view of a contact heating ablation device employing the endoscope-guiding apparatus of the present invention; -
FIG. 14 is a schematic view of a cryogenic ablation device employing the endoscope-guiding apparatus of the present invention; -
FIG. 15 is a schematic view of a ultrasound heating ablation device employing the contacting sensing apparatus of the present invention; and -
FIG. 16 is a schematic illustration of a translation system for independently positioning the endoscope and ablation components of an endoscope/ablator assembly during a procedure. -
FIG. 1 provides a schematic, cross-sectional view of a coaxialcatheter ablation instrument 20 according to the invention, including anelongate body 14 and aprojection balloon 26 inflatable via one ormore ports 22. The instrument is preferably designed such that upon disposition within the heart (e.g., proximal to a pulmonary vein), the projection balloon can be inflated such that a shoulder portion 50 of theballoon 26 will be urged into close proximity with atarget region 52 of cardiac tissue (e.g. an annular region of the atrial heart wall surrounding the ostium of a pulmonary vein). - It should be understood that the embodiments illustrated in the drawings are only a few of the cardiac ablation instruments that can utilized the present invention. Further descriptions of other embodiments can be found, for example, in commonly owned, co-pending U.S. patent application Ser. No. 10/357,156, filed Feb. 3, 2003 and U.S. patent application Ser. No. 09/924,393, filed Aug. 7, 2001, both of which are expressly incorporated by reference.
- The instrument can also include one or
more ports 36 for delivering ablative fluid to the target region. When the device employs radiant energy ablation, the ablative fluid is preferably an energy transmissive medium, which helps deliver light, radiation or acoustic energy from a radiant energy source to a target tissue region. In the case of electrical resistance or conductive heating (or cryogenic cooling), an ablative fluid is also useful to help conduct electrical current or heat to the target site. The ablative fluid also serves to clear blood from the vicinity of the instrument and compensate for irregularities in the shape of the heart that might otherwise compromise the seating of the instrument. The ablative fluid thus provides a clear transmission pathway external to the balloon. - Within the projection balloon 26 a
radiant energy emitter 40 is shown disposed remotely from the target tissue (e.g., within a central lumen of thecatheter body 14 or otherwise disposed within the balloon). In one embodiment, the radiant energy source includes at least one optical fiber coupled to a distal light projecting, optical element, which cooperate to project ablative light energy through the instrument to the target site. The catheter body, projection balloon and inflation/ablation fluids are all preferably substantially transparent to the radiant energy at the selected wavelength to provide a low-loss transmission pathway from theablation element 40 to the target. - Also disposed within the instrument is a reflectance sensor, preferably an
endoscope 76 capable of capturing an image of the target site and/or the instrument position. The endoscope is typically an optical fiber bundle with a lens or other optical coupler at its distal end to receive light. The reflectance sensor/endoscope can also include an illumination source, such as an optical fiber coupled to a light source. Suitable endoscopes are available commercially from various sources including, for example, Myriad Fiber Imaging Tech, Inc. of Southbridge, Mass. The endoscope can further include an optical head assembly, as detailed in more detail below, to increase the field of view. - The term “endoscope” as used herein is intended to encompass optical imaging devices, generally, including but not limited to endoscopes, fiberscopes, cardioscopes, angioscopes and other optical fiber-based imaging devices. More generally, “endoscope” encompasses any light-guiding (or waveguide) structure capable of transmitting an “image” of a object to a location for viewing. The viewing location can be direct, e.g., an eyepiece, or indirect, e.g., an image capture device, such as a CCD camera, which converts image data into a video display.
-
FIG. 1A is a schematic view of an endoscope/ablation element assembly 32 according to the invention including anablation element 40 and anendoscope 76. Theassembly 32 can be adapted for axial movement within an inner lumen ofcatheter body 14. In one preferable embodiment,ablation element 40 andendoscope 76 are adapted for independent axial movement within theassembly 32. -
FIG. 2 is a schematic illustration of an initial step in performing ablative surgery with radiant energy according to the invention, in which aguide wire 6 is introduced into aheart 2 and passed into a pulmonary vein 4. -
FIG. 3A is a schematic illustration of a method of performing ablative surgery with radiant energy according to the invention. Afterguide wire 6 is be introduced into a heart and passed into a pulmonary vein 4,catheter 20, carryingprojection balloon structure 26, is slid over theguide wire 6. Thiscatheter 20 can further include at least one internal fluid passageway (not shown) for inflation of theballoon 26, which is sealed to the body of thecatheter 20 bydistal seal 21 andproximal seal 22, such that the introduction of an inflation fluid into theballoon 26 can inflate the balloon. -
FIG. 3B illustrates how theprojection balloon 26 can then be inflated to define a projection pathway for radiant energy ablation of cardiac tissue. The expanded projection balloon defines a staging through which radiant energy can be projected in accordance with the invention. In one preferred embodiment, the projection balloon is filled with a radiation-transmissive fluid so that radiant energy from an energy emitter can be efficiently passed through the instrument to a target region of cardiac tissue. - The projection balloons described herein can be preshaped to form parabolic like or various other shapes (e.g., to assist in seating the instrument at the mouth of a pulmonary vein or otherwise engaging the vein ostium or other anatomically defined regions of the heart). This can be accomplished, for example, by shaping and melting a TEFLON° film in a preshaped mold to effect the desired form. The projection balloons of the present invention can be made, for example, of thin wall polyethylene teraphthalate (PET) with a thickness of the membranes of about 5-50 micrometers.
- It should be noted that it is not necessary for the
projection balloon 26 to contact the target tissue in order to ensure radiant energy transmission. One purpose of the projection balloon is simply to clear a volume of blood away from the path of the energy emitter. With reference again toFIG. 1 , anablative fluid 29 can be employed outside of the instrument (e.g., between theballoon 26 and the target region 52) to ensure efficient transmission of the radiant energy when the instrument is deployed. The ablative fluid in this context is any fluid that can serve as a conductor of the radiant energy. This ablative fluid can be a physiologically compatible fluid, such as saline, or any other non-toxic aqueous fluid that is substantially transparent to the radiation. As shown inFIG. 1 , the fluid 29 can be released via one ormore exit ports 36 in thefirst catheter body 14 to flow between theprojection balloon 26 and the surrounding tissue, thereby filling any gaps where theballoon 26 does not contact the tissue. The fluid 29 can also serve an irrigation function by displacing any blood within the path of the radiant energy, which could otherwise interfere with the radiant light energy transmission to thetarget region 52. - For alternative designs for delivery of ablative and/or irrigation fluids, see commonly-owned, U.S. patent application Ser. No. 09/660,601, filed Sep. 13, 2000 entitled “Balloon Catheter with Irrigation Sheath,” the disclosures of which are hereby incorporated by reference. For example, in one embodiment described in patent application Ser. No. 09/660,601, the projection balloon can be partially surrounded by a sheath that contains pores for releasing fluid near or at the target ablation site. One of ordinary skill in the art will readily appreciate that such pores can vary in shape and/or size. A person having ordinary skill in the art will readily appreciate that the size, quantity, and placement of the fluid ports of various designs can be varied to provide a desired amount of fluid to the treatment site.
-
FIG. 4 is a schematic illustration of a further step in performing ablative surgery according to the invention, in which the guide wire is removed and replaced by aenergy emitter 40 located remote from the desiredlesion site 52 but in a position that permits projection of radiant energy onto a target region of the heart. The energy emitter can be introduced into the instrument via the lumen of the inner catheter. In the illustrated embodiment, shown in more detail inFIG. 7 , theenergy emitter 40 is a radiant energy emitter and includes at least oneoptical fiber 42 coupled to a distal light projecting, optical element 43, which cooperate to project ablative light energy through the instrument to the target site. In one embodiment, optical element is a lens element capable of projecting an annular (ring-shaped) beam of radiation, as described in more detail in commonly owned U.S. Pat. No. 6,423,055 issued Jul. 22, 2002, herein incorporated by reference. In another embodiment, the optical element is adapted to project an arc-like pattern of radiation and the energy emitter can be rotated and/or translated to encircle the pulmonary vein. Alternatively, the radiant energy emitter can be an ultrasound or microwave energy source, as described in more detail below (in connection withFIGS. 9-10 ). -
FIGS. 4 and 5 , taken together, also illustrate an advantageous feature of the present invention, namely, the ability to select the location a lesion independent of the instrument design. Because the radiant energy emitter does not require contact with a target tissue region and is, in fact, decoupled from the rest of the instrument, the present invention permits the clinician to select a desired target region by simply moving the emitter (e.g., within the lumen of the catheter). As shown inFIG. 4 , the radiant energy emitter can be positioned to form a wide circumferential lesion (when the shape of the pulmonary vein ostium warrants such a lesion) by positioning the radiant energy emitter at the rear of the projection balloon—at a distance from the target tissue denoted as “C”. Alternatively, a smaller diameter lesion can be formed by positioning the radiant energy emitter closer to the front of the project balloon, as shown in positions “A” or “B”. Smaller lesions can be preferably when the geometer of the vein ostium presents a sharper change in diameter, as shown by schematic wall segment 4B. It should be appreciated that it may be desirable to change the intensity of the emitted radiation depending upon the distance it must be projected; thus a more intense radiant energy beam may be desirable in the scheme illustrated in position “C” in comparison with position “A.”. Theenergy emitter 40 andcatheter body 14 can each include one or more markers (shown schematically aselements 33 and 35 respectively) to aid in determining the location or tracking movements of the elements.Markers 33 and 35, for example, can be radioopaque lines that can visualized fluoroscopically. - In addition the expandable element can include an
orientation marker 57 which can be visualized endoscopically to visualize the position and/or orientations of the instrument. Each of themarkers balloon neck marker 57, with one or more azimuthal cross-marks) to assist in orientation. Various other marker mechanisms, such as magnetic, capacitive or optical markers, can also be used. - Typically with prior art devices, the target site, e.g., the ostium of a pulmonary vein, can only be located by fluoroscopic inspection during injection of a contrast medium into the vein. Such images are transient. Location of the ablation catheter itself, even with radiopaque markers is likewise difficult because of the geometry of the heart. Moreover the heart's structure is largely invisible during fluoroscopic inspection.
- The endoscopic guidance systems of the present invention coupled with the use of orientation markers can help overcome these problems. The use of radioopaque markers on the endoscope and/or the catheter allow the user to orient the ablation instrument relative to the pulmonary vein and permit anatomical features seen via the endoscope to be combined with fluoroscopic information. Orientation markers, such as
elements 33 and 35 can be used to determine the angular position of the instrument relative to structures such the ostia and also provide a measure of how far a movable element, such as theenergy emitter 40, has been advanced within the instrument. (It should be appreciated that numerous other marker schemes can be employed to achieve these objectives, including ring markers on either the energy emitter and/or the catheter body.) - Similarly, the ring marker shown as
element 57 on theprojection balloon 26 can be replaced by a series of rings. Alternatively, if the endoscope is maintained in a fixed position relative to the balloon, physical markers can be replaced with virtual markers generated electronically as part of the display. Such information is particularly useful in selection one or more of alternative sites for ablation. In addition to the movable energy emitters described herein, the invention can be used in conjunction with two or more fixed ablation elements (e.g., resistive heating bands of different circumferences) to select the most appropriate one (or set) of the ablation elements to be activated for lesion formation. - The endoscopic guidance systems of the present invention can further be used to position any movable point source of ablative energy, e.g., a rotating contact or radiant ablation element in lieu of a slidably positionable source or together therewith, such that the desired path for circumferential can be visualized and followed by the ablation element. Most generally, the endoscopic guidance systems of the invention can be used together with various fluoroscopic or other imaging techniques to location and position anyone of the various instruments necessary for cardiac ablation.
- The ability to position the energy emitter, especially when radiant light is employed as the ablation modality, also permits endoscopic aiming of the energy. For example, an aiming light beam can be transmitted via the catheter to the target site such that the physician can visualize where the energy will be delivered. Thus, endoscopic guidance permits the user to see where energy will be projected at various locations of the energy emitter. Thus, if the instrument is designed to project light in an annular ring around the ostium of a pulmonary vein, the aiming beam can be projected down the same optical delivery path as would the radiant energy. If the “aiming ring” is projected onto a region of the atrium where a clear transmission pathway is seen (e.g., there is continuous contact (or the desired lesion path is otherwise cleared of blood), then the physician can begun the procedure. If, on the other hand, a clear transmission pathway is not seen at a particular location of the ablation element, then the ablation element can be moved until a clear lesion pathway is found.
- Although this “aiming” feature of the invention has been described in connection with radiant light energy sources, it should be clear that “aiming” can be used advantageously with any radiant energy source and, in fact, it can also assist in the placement of fixed or contact based ablation elements. Most generally, endoscope-guidance can be combined with an aiming beam in any cardiac ablation system to improve positioning and predetermination of successful lesion formation.
- The terms “visual,” “visualize” and derivatives thereof are used herein to describe both human and machine uses of reflectance data. Such data can take the form of images visible to a clinician's eye or any machine display of reflected light, e.g., in black & white, color or so-called “false color” or color enhanced views. Detection and display of reflected energy measurements outside the visible spectrum are also encompassed. In automated systems such visual data need not be displayed but rather employed direct by a controller to aid in the ablation procedure.
-
FIG. 4-5 further illustrates the unique utility of the multi-positionable, radiant energy ablation devices of the present invention in treating the complex cardiac geometries that are often encountered. As shown in the figure, the mouths of pulmonary veins typically do not present simple, funnel-shaped, or regular conical surfaces. Instead, one side of the ostium 4B can present a gentle sloping surface, while anotherside 4A presents a sharper bend. With prior art, contact-heating, ablation devices, such geometries will result in incomplete lesions if the heating element (typically a resisting heating band on the surface of an expandable element) can not fully engage the tissue of the vein or ostium. Because the position of the heating band of the prior art devices is fixed, when it does not fully contact the target tissue, the result is an arc, or incompletely formed ring-type, lesion that typically will be insufficient to block conduction. -
FIG. 4 illustrates how the slidably positionable energy emitters of the present invention can be used to avoid this problem. Three potential positions of theemitter 40 are shown in the figure (labeled as “A”, “B” and “C”). As shown, positions A and C may not result in optimal lesions because of gaps between the balloon and the target tissue. Position B, on the other hand, is preferably because circumferential contact has been achieved. Thus, the independent positioning of the energy source relative to the balloon allows the clinician to “dial” an appropriately ring size to meet the encountered geometry. (Although three discrete locations are shown inFIG. 4 , it should be clear that emitter can be positioned in many more positions and that the location can be varied in either discrete intervals or continuously, if so desired.) - Moreover, in some instances the geometries of the pulmonary vein (or the orientation of the projection balloon relative to the ostium) may be such that no single annular lesion can form a continuous conduction block. Again, the present invention provides a mechanism for addressing this problem by adjustment of the location of the energy emitter to form two or more partially circumferential lesions. As shown in
FIG. 5 , the devices of the present invention can form afirst lesion 94 and asecond lesion 96, each in the form of an arc or partial ring. Because each lesion has a thickness (dependent largely by the amount of energy deposited into the tissue) the two lesions can axially combine, as shown, to form a continuous encircling or circumscribing lesion that blocks conduction. -
FIG. 6 is a schematic block diagram shown the endoscope/ablator assembly 32 comprisingendoscope 76 andablation element 40 connected to an analyzer system. The analyzer system further includes adetector 34 for detecting reflected light (and preferable for generating a image). The output of thedetector 34 can be transmitted to adisplay 36 for clinician viewing. Thedisplay 36 can be a simple eyepiece, a monitor or a heads-up projection onto glasses worn by members of the surgical team. The system can further include anenergy source 39, acontroller 37 and a user interface 38. In use, theendoscope 76 captures images which can be processed by thedetector 34 and/orcontroller 37 to determine whether a suitable ablation path can be created. An aiminglight source 31 can also be used visualize the location where energy will be delivery to the tissue. If a suitable ablation path is seen by the surgeon, thecontroller 37 can transmit radiant energy from theablation element 39 to a target tissue site to effect ablation. The controller can further provide simulated displays to the user, superimposing, for example, a predicted lesion pattern on the image acquired by the detector or superimposing dosimetry information based on the lesion location. The controller can further include a memory for storing and displaying data, such as pre-procedure images, lesion predictions and/or actual outcomes. The controller can further provide a safety shutoff to the system in the event that a clear transmission pathway between the radiant energy source and the target tissue is lost during energy delivery. -
FIG. 7 is a schematic illustration of one embodiment of aradiant energy emitter 40A according to the invention. In one preferred embodiment, the radiant energy is electromagnetic radiation, e.g., coherent or laser light, and theenergy emitter 40A projects an hollow cone of radiation that forms an annular exposure pattern upon impingement with a target surface. For example,radiant energy emitter 40A can include anoptical fiber 42 in communication with an annulus-forming optical waveguide 44 having a concave interior boundary orsurface 45. The waveguide 44 passes an annular beam of light to a graded intensity (GRIN)lens 46, which serves to collimate the beam, keeping the beam width the same, over the projected distance. The beam that exits from thedistal window 48 ofenergy emitter 40 will expand (in diameter) over distance, but the energy will remain largely confined to a narrow annular band. Generally, the angle of projection from the central axis of theoptical fiber 42 or waveguide 44 will be between about 20 and 60 degrees (for a total subtended angle of about 40 to about 120 degrees). - The diameter of the annular beam of light will be dependent upon the distance from the point of projection to point of capture by a surface, e.g., a tissue site, e.g., an interstitial cavity or lumen. Typically, when the purpose of the radiant energy projection is to form a transmural cardiac lesion, e.g., around a pulmonary vein, the diameter of the annular beam will be between about 10 mm and about 33 mm, preferably greater than 10 mm, greater than 15 mm, greater than 20 mm, and most preferably, greater than or equal to 23 mm. Typically, angle of projected annular light is between about 20 and about 60 degrees, preferably between about 45 and about 55 degrees, most preferably in some applications about 50 degrees (total subtended angle 100 degrees).
- Preferred energy sources for use with the percutaneous ablation instruments of the present invention include laser light in the range between about 200 nanometers and 2.5 micrometers. In particular, wavelengths that correspond to, or are near, water absorption peaks are often preferred. Such wavelengths include those between about 805 nm and about 1060 nm, preferably between about 900 nm and 1000 nm, most preferably, between about 915 nm and 980 nm. In a preferred embodiment, wavelengths around 915 nm or around 980 nm are used during endocardial procedures. Suitable lasers include excimer lasers, gas lasers, solid state lasers and laser diodes. One preferred AlGaAs diode array, manufactured by Spectra Physics, Tucson, Ariz., produces a wavelength of 980 nm.
- The optical waveguides, as described in above, can be made from materials known in the art such as quartz, fused silica or polymers such as acrylics. Suitable examples of acrylics include acrylates, polyacrylic acid (PAA) and methacrylates, polymethacrylic acid (PMA). Representative examples of polyacrylic esters include polymethylacrylate (PMA), polyethylacrylate and polypropylacrylate. Representative examples of polymethacrylic esters include polymethylmethacrylate (PMMA), polymethylmethacrylate and polypropylmethacrylate. In one preferred embodiment, the waveguide 44 is formed of quartz and fused to the end face of
fiber 42. - Internal shaping of the waveguide can be accomplished by removing a portion of material from a unitary body, e.g., a cylinder or rod. Methods known in the art can be utilized to modify waveguide to have tapered inner walls, e.g., by grinding, milling, ablating, etc. In one approach, a hollow polymeric cylinder, e.g., a tube, is heated so that the proximal end collapses and fuses together, forming an integral proximal portion which tapers to the distal end of the waveguide. In another approach, the
conical surface 45 can be formed in a solid quartz cylinder or rod by drilling with a tapered bore. - Waveguide 44 can be optical coupled to
optical fiber 42 by various methods known in the art. These methods include for example, gluing, or fusing with a torch or carbon dioxide laser. In one embodiment, waveguide 44,optical fiber 42 and, optionally, a gradient index lens (GRIN) 46 are in communication and are held in position by heat shrinking apolymeric jacket material 49, such as polyethylene terephthalate (PET) about theoptical apparatus 40. -
FIG. 8 is a schematic illustration of another embodiment of aradiant energy emitter 40B according to the invention in whichoptical fiber 42 is coupled to alight diffuser 41 havinglight scattering particles 47 to produce a sidewise cylindrical exposure pattern of ablative radiation. This embodiment can be useful, for example, in creating a lesion within a pulmonary vein. With reference again toFIG. 4 , it should be clear that the radiant energy emitter of the design shown inFIG. 14 can be advanced to the front of the projection balloon to permit diffuse exposure of a pulmonary vein ostium if a lesion is desired in that location. For further details on the construction of light diffusing elements, see U.S. Pat. No. 5,908,415 issued to Sinofsky on Jun. 1, 1999, herein incorporated by reference. -
FIG. 9 illustrates an alternative embodiment of aradiant energy emitter 40C in which anultrasound transducer 60, comprising individual shaped transducer elements (and/or lenses or reflectors) 62 which direct (project) the ultrasound energy into a cone of energy that can likewise form an annular exposure pattern upon impingement with a target surface. Theemitter 40C is supported by asheath 66 or similar elongate body, enclosing electrical leads, and thereby permitting the clinician to advance the emitter through an inner lumen of the instrument to a desired position for ultrasound emission. - Yet another embodiment of a
radiant energy emitter 40D is illustrated inFIG. 10 where microwave energy is similarly focused into an annular exposure beam. As shown inFIG. 10 , the radiant energy emitter can include a coaxial transmission line 74 (or similar electrical signal leads) and ahelical coil antenna 73.Radiation reflectors 72A and 72B cooperated to shield and direct the radiation into a cone. In other embodiments, a radioisotope or other source of ionizing radiation can be used in lieu of themicrowave antenna 73, again with appropriateradiation shielding elements 72A and 72B to project a beam of ionizing radiation. -
FIGS. 11 and 12 illustrate one embodiment of a contact sensor according to the invention incorporated into a radiant emitter assembly. The assembly can includes anassembly body 32 that encases an endoscope/ablator assembly and facilitates slidable positioning within an inner lumen ofcatheter body 14. The assembly further includes an energy emitter 40 (e.g., like those described above in connection withFIGS. 7-10 ) which can also act as the sensing fiber. In the illustrated embodiment, anablation element 40 is shown which can act as an illumination light source (when operated a low power). If the ablative element of the invention is properly positioned within the heart, light transmitted via such ablation element will strike the target region, be reflected back, and detected by thereflectance sensor 76. It should be clear that the invention can be practiced with various numbers of illuminating and/or sensing elements, and with or without use of the energy emitter as an element in the contact sensing module. The emitter and the endoscope can each move independently, if desired. Moreover, ultrasound emitters and detectors can also be used in the same manner in lieu of the light reflecting mechanisms to determine contact. In any event, the output signals of the sensors can be electronically processed and incorporated into a display. - The devices of the present invention can further include illumination elements that are capable of diffusing light to a large contact area of tissue by employing a scattering medium at the distal end of the illumination fiber. Examples of this diffusing material can be a matrix of titanium dioxide particles suspended in cured silicone. This diffusing medium allows high intensity light to be uniformly diffused over a large area preferably over an area greater than 40 mm in diameter.
-
Endoscope 76, as shown inFIG. 11 , can include anoptical fiber bundle 78 for transmitting the captured image back to a detector and display, as well as alenses - The endoscopes of
FIGS. 11-12 provide the ability to position the percutaneous ablation instruments of the present invention at a treatment site such that proper location of the energy emitter vis-a-vis the target tissue (as well a satisfactory degree of contact between the projection balloon and the tissue) is achieved. -
FIG. 11A provides a detailed schematic illustration of anendoscope 76A with enhanced field of view. The endoscope can include afiber bundle 130 within aprotective polyimide tube 132 coupled to distalstainless steel tube 134 in which the field-enhancing optics are disposed. Withindistal tube 134, animaging lens 136 and anobjective lens 140 are situated, together with a centering and connecting tubes (e.g.,tube 135 and 142) as may be needed to secure the lenses in place. (It should be appreciated that various lens combination or compound lens structures can be substituted for the elements shown inFIG. 11A .) - The
endoscope 76A is designed to have a wide field of view even while it is immersed in liquid. The liquid in which it is immersed typically can be either physiological saline in the inner lumen of the catheter or deuterium oxide which is one preferred medium for filling applicants' projection balloon. Both of these liquids have essentially the same index of refraction. To achieve the wide field of view a lens system shownFIG. 11A can be used. The lens system consists of two plano-convex lenses aperture window 144. High index of refraction materials are preferably used for the lenses. Suitable materials include sapphire, cubic zirconia or high index glass materials. Alternatively, air-filled optical structures can be substituted for the solid lenses shown in the figure. All these materials are readily available as small diameter spheres with optical quality surfaces. The spheres can be made into hemispheres and the diameter of the hemispheres are reduced using common lens grinding technology. The aperture can be constructed by metallizing one surface of flat glass plate. The central aperture hole is created by masking the flat glass before the metallization or removing the metallization with a laser. - Sample specifications for the lens elements are as follows:
-
TABLE 1 Lens Specifications Element Spherical Overall Center Name Material Radius Diameter thickness Object Lens Cubic Zirconia or 0.200 mm 0.400 mm 0.244 mm high index glass Image Lens Saphire or high 0.300 mm 0.400 mm 0.187 mm index glass Aperture Schott B270 Flat on both 0.400 mm 0.125 mm Window Grade A Faces 0.060 mm glass dia. - This lens system has field of view of slightly larger than 110° when immersed in water, an f number of about 2.5 and a depth of field that provides acceptable focus over a range of object distances from 13 mm to 40 mm. Acceptable focus is that degree of focus that results in minimum resolvable spot diameters that are close in size to 5 microns, which is the size of the individual fibers in the image bundle of the endoscope.
- In the design described above the lens elements can be assembled so the spherical surfaces touch and therefore the elements are self-locating when assembled in a small
lens cell tube 138 with an inner diameter just slightly larger than the outer diameter of the lens elements. Once the lens cell is fabricated it is attached to the image bundle using techniques common to those skilled in the art. The general assembly can use precise diameter tubes of polyimide whose dimensions can be controlled very precisely and whose wall thicknesses can be made very thin. - The ability have a field of view greater that 50 degrees (and, preferably, in some applications, greater than 70 degrees, or 90 degrees) can be important because of the geometry of the heart and the ablation elements. Visualization the ostium of a pulmonary vein inherently requires a wide field of view. Moreover, the ablation element (including any expandable element) must be short because of the limited space available within the atrial chamber. These two factors combine to require the placement of the endoscope close to the vein and an even wider field of view is desirable, typically greater than 70 degrees, in order to visualize the target region and the instrument's position relative to the target region. Moreover, the wide field of view allows the clinician to see well proximal to the apex of the balloon; thus providing the ability to determine if the instrument is places too distally in the pulmonary vein.
- The endoscopes of the present invention can also be used in conjunction with other optical reflectance measurements of light scattered or absorbed by blood, body fluids and tissue. For example, white light projected by an illumination source toward tissue has several components including red and green light. Red light has a wavelength range of about 600 to about 700 nanometers (nm) and green light has a wavelength range of about 500 to about 600 nm. When the projected light encounters blood or body fluids, most if not all green light is 30 absorbed and hence very little green or blue light will be reflected back toward the optical assembly which includes a reflected light collector. As the apparatus is positioned such that blood and body fluids are removed from the treatment field cleared by an inflated balloon member, the reflectance of green and blue light increases as biological tissue tends to reflect more green light. As a consequence, the amount of reflected green or blue light determines whether there is blood between the apparatus and the tissue or not.
- Thus, the endoscopic displays of the present invention can incorporate filters (or generate “false-color” images) that emphasize the presence or absence of blood in the field. For example, when the inflated balloon member contacts the heart tissue (or is close enough that the balloon and ablative fluid released by the instrument form a clear transmission pathway), more green light will be reflected hack into the optical assembly and the collector. The ratio of two or more different wavelengths can be used to enhance the image. Accordingly, a color-enhanced endoscope permit visualization of the instrument and/or the target site, as well as a determination of whether blood precludes the formation of a continuous lesion, e.g., circumferential lesion around the ostium of a pulmonary vein.
- Alternatively, spectrographic measurements can be taken in tandem with endoscopic imaging, Thus, reflected light can be transmitted back through a collector, such as an optical fiber to a spectrophotometer. The spectrophotometer (Ocean Optics Spectrometer, Dunedin, Fla., model S-2000) produces a spectrum for each reflected pulse of reflected light. Commercially available software (LabView Software, Austin, Tex.) can isolate values for specific colors and perform ratio analyses.
- Once the operator is satisfied with the positioning of the instrument, radiant energy can then be projected to the target tissue region. If the radiant energy is electromagnetic radiation, e.g., laser radiation, it can be emitted onto the tissue site via a separate optical fiber or, alternatively, through the same optical fiber used to transmitting the white, green or red light. The laser light can be pulsed intermittently in synchronous fashion with the positioning/reflecting light to ensure that the pathway remains clear throughout the procedure.
- It should be clear that the imaging and contact sensing aspects of the present invention are not limited to radiant energy ablation devices but can also be useful in placement of contact heating or cooling ablation instruments as well. For example, in
FIG. 13 , a contact-heating device 54 having anexpandable element 56 and acontact heating element 58 is shown disposed in a pulmonary vein. The contact heating element can be a line or grid of electrically conductive material printed on the surface of the expandable element. In one embodiment, the expandable element can be substantially opaque to certain wavelengths (e.g., visible light) except for atransparent band 59, on which the contact heating element is situated. The heating wires should also be sufficiently transparent (or cover a substantially small area of the band) so as to not interfere with reflection signal collection. Thedevice 54 can further include a sensor, e.g., an endoscope, disposed within a central lumen of the device having an illuminating fiber and a plurality of collecting fibers. - In
FIG. 14 , another embodiment of a reflectance sensing or endoscope-guided catheter is shown in the form of acryogenic ablation catheter 110 having acatheter body 112 andinternal conduits 114 for circulation of a cryogenic fluid from a cryogenicfluid source 115. The catheter body can include an expandable portion, e.g., a balloon structure, and further includesconductive regions 116 where the cold temperature can be applied to tissue. Theendoscope 76 of the present invention can be disposed in proximity to the conductive regions, as shown and used to determine whether tissue contact has been made. - In
FIG. 15 yet another application for the contact sensors is shown in connection with an ultrasound, contact-heating balloon catheter 120, having a balloon 122 (similar to that discussed above in connection withFIG. 13 ) for contacting a pulmonary vein ostium and having anoptional band 123 for applying heat to tissue. Theultrasound ablation instrument 120 further includestransducers 124 driven byactuator 125 to heat a desired region of tissue. Theinstrument 120 can also includedreflectors 126 to project the ultrasound energy through the balloon into an annular focus in the target tissue (or at the surface of the balloon). Again, the reflectance orendoscopic sensors 76 of the present invention can be disposed within the balloon or catheter body, as shown, and used to determine whether tissue contact has been made. - In
FIG. 16 , atranslatory mechanism 80 is shown for controlled movement of a radiant energy emitter within the instruments of the present invention. Theexemplary positioner 80 is incorporated into ahandle 84 in the proximal region of the instrument, where theelongate body 82 of theradiant energy emitter 40 engages athumb wheel 86 to control advancement and retraction of the emitter. It should be clear that various alternative mechanisms of manual or automated nature can be substituted for the illustratedthumb wheel 86 to position the emitter at a desired location relative to the target tissue region. - In addition, as shown in
FIG. 16 , theelongate body 82 that supports the radiant energy emitter 40 (e.g., an optical fiber assembly as shown inFIGS. 11-12 or the sheath for the electrical leads as shown in connection withFIGS. 9-10 ) can further include position indicia 92 on its surface to assist the clinician in placement of the ablation element within the instrument. The handle can further include awindow 90 whereby the user can read the indicia (e.g., gradation markers) to gauge how far the emitter has been advanced into the instrument. - The
assembly 32 can further include anendoscope translatory mechanism 98 as shown inFIG. 16 for controlled movement of the reflectance sensor orendoscope 76 within the instruments of the present invention. Theexemplary positioner 98 can be incorporated into ahandle 99 in the proximal region of the instrument, where the elongate body of thesensor 76 engages athumb wheel 97 to control advancement and retraction of the emitter. - The apparatus of the present invention thus permits the selection of an ablative lesion, e.g., a circumferential lesion, of desired shape and size. This adjustability can be used advantageously to form a lesion at a desired location, or along a desired path, to effectively block conduction and thereby treat atrial fibrillation.
- Although described in connection with cardiac ablation procedures, it should be clear that the instruments of the present invention can be used for a variety of other procedures where treatment with radiant energy is desirable, including laparoscopic, endoluminal, perivisceral, endoscopic, thoracoscopic, intra-articular and hybrid approaches.
- The term “radiant energy” as used herein is intended to encompass energy sources that do not rely primarily on conductive or convective heat transfer. Such sources include, but are not limited to, acoustic and electromagnetic radiation sources and, more specifically, include microwave, x-ray, gamma-ray, ultrasonic and radiant light sources. The term “light” as used herein is intended to encompass electromagnetic radiation including, but not limited to, visible light, infrared and ultraviolet radiation.
- The term “continuous” in the context of a lesion is intended to mean a lesion that substantially blocks electrical conduction between tissue segments on opposite sides of the lesion. The terms “circumferential” and/or “curvilinear,” including derivatives thereof, are herein intended to mean a path or line which forms an outer border or perimeter that either partially or completely surrounds a region of tissue, or separate one region of tissue from another. Further, a “circumferential” path or element may include one or more of several shapes, and may be for example, circular, annular, oblong, ovular, elliptical, semi annular, or toroidal.
- The term “lumen,” including derivatives thereof, in the context of biological structures, is herein intended to mean any cavity or lumen within the body which is defined at least in part by a tissue wall. For example, cardiac chambers, the uterus, the regions of the gastrointestinal tract, the urinary tract, and the arterial or venous vessels are all considered illustrative examples of body spaces within the intended meaning.
- The term “catheter” as used herein is intended to encompass any hollow instrument capable of penetrating body tissue or interstitial cavities and providing a conduit for selectively injecting a solution or gas, including without limitation, venous and arterial conduits of various sizes and shapes, bronchoscopes, endoscopes, cystoscopes, culpascopes, colonscopes, trocars, laparoscopes and the like. Catheters of the present invention can be constructed with biocompatible materials known to those skilled in the art such as those listed supra, e.g., silastic, polyethylene, Teflon, polyurethanes, etc. The term “lumen” including derivatives thereof, in the context of catheters is intended to encompass any passageway within a catheter instrument (and/or track otherwise joined to such instrument that can serve as a passageway) for the passage of other component instruments or fluids or for delivery of therapeutic agents or for sampling or otherwise detecting a condition at a remote region of the instrument. The term “catheter” is also intended to encompass any elongate body capable of serving as a conduit for one or more of the ablation, expandable or sensing elements described herein, e.g., energy emitters, balloons and/or endoscopes. Specifically in the context of coaxial instruments, the term “catheter” can encompass either the outer catheter body or sheath or other instruments that can be introduced through such a sheath. The use of the term “catheter” should not be construed as meaning only a single instrument but rather is used to encompass both singular and plural instruments, including 30 coaxial, nested and other tandem arrangements.
- The term “vessel” or “blood vessel” includes, without limitation, veins, arteries, and various chambers or regions of the heart, such as the atria, ventricles, coronary sinus, vena cava and, in particular, the ostia or antrum of the pulmonary veins.
- It should be understood that the term “balloon” encompasses deformable hollow shapes which can be inflated into various configurations including balloon, circular, tear drop, etc., shapes dependent upon the requirements of the body cavity. Such balloon elements can be elastic or simply capable of unfolding or unwrapping into an expanded state. The balloon can further encompass multiple chamber configurations.
- The term “transparent” is well recognized in the art and is intended to include those materials which allow transmission of energy through, for example, the primary balloon member. Preferred transparent materials do not significantly impede (e.g., result in losses of over 20 percent of energy transmitted) the energy being transferred from an energy emitter to the tissue or cell site. Suitable transparent materials include fluoropolyrners, for example, fluorinated ethylene propylene (FEP), perfluoroalkoxy resin (PFA), polytetrafluoroethylene (PTFE), and ethylene-tetrafluoroethylene (ETFE) or polyester resins including polyethylene teraphathalate (PET).
- One skilled in the art will appreciate further features and advantages of the invention based on the above-described embodiments. Accordingly, the invention is not to be limited by what has been particularly shown and described, except as indicated by the appended claims. All publications and references cited herein are expressly incorporated herein by reference in their entirety.
Claims (21)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/380,637 US9861437B2 (en) | 1999-07-14 | 2016-12-15 | Guided cardiac ablation catheters |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/357,355 US6423055B1 (en) | 1999-07-14 | 1999-07-14 | Phototherapeutic wave guide apparatus |
US09/602,420 US6572609B1 (en) | 1999-07-14 | 2000-06-23 | Phototherapeutic waveguide apparatus |
US09/616,275 US6626900B1 (en) | 1999-07-14 | 2000-07-14 | Intralumenal contact sensor |
US09/924,393 US6676656B2 (en) | 1994-09-09 | 2001-08-07 | Surgical ablation with radiant energy |
US10/357,156 US8025661B2 (en) | 1994-09-09 | 2003-02-03 | Coaxial catheter instruments for ablation with radiant energy |
US47737403P | 2003-06-10 | 2003-06-10 | |
US10/674,114 US6942657B2 (en) | 1999-07-14 | 2003-09-29 | Intralumenal contact sensor |
US10/865,558 US8540704B2 (en) | 1999-07-14 | 2004-06-10 | Guided cardiac ablation catheters |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/865,558 Continuation US8540704B2 (en) | 1999-07-14 | 2004-06-10 | Guided cardiac ablation catheters |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/380,637 Continuation US9861437B2 (en) | 1999-07-14 | 2016-12-15 | Guided cardiac ablation catheters |
Publications (1)
Publication Number | Publication Date |
---|---|
US20140031802A1 true US20140031802A1 (en) | 2014-01-30 |
Family
ID=34317837
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/865,558 Expired - Lifetime US8540704B2 (en) | 1999-07-14 | 2004-06-10 | Guided cardiac ablation catheters |
US13/952,013 Abandoned US20140031802A1 (en) | 1999-07-14 | 2013-07-26 | Guided cardiac ablation catheters |
US15/380,637 Expired - Fee Related US9861437B2 (en) | 1999-07-14 | 2016-12-15 | Guided cardiac ablation catheters |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/865,558 Expired - Lifetime US8540704B2 (en) | 1999-07-14 | 2004-06-10 | Guided cardiac ablation catheters |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/380,637 Expired - Fee Related US9861437B2 (en) | 1999-07-14 | 2016-12-15 | Guided cardiac ablation catheters |
Country Status (1)
Country | Link |
---|---|
US (3) | US8540704B2 (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160143522A1 (en) * | 2014-11-25 | 2016-05-26 | LuxCath, LLC | Visualization Catheters |
US20180075728A1 (en) * | 2015-03-12 | 2018-03-15 | James Liu | Wireless mesh network gas detection real time location system |
US10076238B2 (en) | 2011-09-22 | 2018-09-18 | The George Washington University | Systems and methods for visualizing ablated tissue |
US10143517B2 (en) | 2014-11-03 | 2018-12-04 | LuxCath, LLC | Systems and methods for assessment of contact quality |
US10156552B2 (en) | 2015-05-13 | 2018-12-18 | Honeywell International Inc. | Method to auto-configure gas detectors based on real-time location |
USD851245S1 (en) | 2017-04-14 | 2019-06-11 | Cardiofocus, Inc. | Compliant balloon |
US10722301B2 (en) | 2014-11-03 | 2020-07-28 | The George Washington University | Systems and methods for lesion assessment |
US10736512B2 (en) | 2011-09-22 | 2020-08-11 | The George Washington University | Systems and methods for visualizing ablated tissue |
US10779904B2 (en) | 2015-07-19 | 2020-09-22 | 460Medical, Inc. | Systems and methods for lesion formation and assessment |
US11096584B2 (en) | 2013-11-14 | 2021-08-24 | The George Washington University | Systems and methods for determining lesion depth using fluorescence imaging |
US11146723B2 (en) | 2016-12-16 | 2021-10-12 | Sony Corporation | Optical scope system for capturing an image of a scene |
US11154186B2 (en) | 2015-07-31 | 2021-10-26 | University Of Utah Research Foundation | Devices, systems, and methods for imaging and treating a selected tissue |
US11344365B2 (en) | 2016-01-05 | 2022-05-31 | Cardiofocus, Inc. | Ablation system with automated sweeping ablation energy element |
US11389236B2 (en) | 2018-01-15 | 2022-07-19 | Cardiofocus, Inc. | Ablation system with automated ablation energy element |
US11457817B2 (en) | 2013-11-20 | 2022-10-04 | The George Washington University | Systems and methods for hyperspectral analysis of cardiac tissue |
US11602270B2 (en) | 2017-02-01 | 2023-03-14 | University Of Utah Research Foundation | Devices and methods for mapping cardiac tissue |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8025661B2 (en) * | 1994-09-09 | 2011-09-27 | Cardiofocus, Inc. | Coaxial catheter instruments for ablation with radiant energy |
US8900219B2 (en) * | 1999-07-14 | 2014-12-02 | Cardiofocus, Inc. | System and method for visualizing tissue during ablation procedures |
US7935108B2 (en) | 1999-07-14 | 2011-05-03 | Cardiofocus, Inc. | Deflectable sheath catheters |
US9033961B2 (en) * | 1999-07-14 | 2015-05-19 | Cardiofocus, Inc. | Cardiac ablation catheters for forming overlapping lesions |
US8540704B2 (en) | 1999-07-14 | 2013-09-24 | Cardiofocus, Inc. | Guided cardiac ablation catheters |
US8614768B2 (en) * | 2002-03-18 | 2013-12-24 | Raytheon Company | Miniaturized imaging device including GRIN lens optically coupled to SSID |
US10610406B2 (en) * | 2004-07-21 | 2020-04-07 | Vanderbilt University | Drug delivery device and applications of same |
US9510732B2 (en) | 2005-10-25 | 2016-12-06 | Intuitive Surgical Operations, Inc. | Methods and apparatus for efficient purging |
US10064540B2 (en) | 2005-02-02 | 2018-09-04 | Intuitive Surgical Operations, Inc. | Visualization apparatus for transseptal access |
US7860555B2 (en) | 2005-02-02 | 2010-12-28 | Voyage Medical, Inc. | Tissue visualization and manipulation system |
US20080015569A1 (en) | 2005-02-02 | 2008-01-17 | Voyage Medical, Inc. | Methods and apparatus for treatment of atrial fibrillation |
US8078266B2 (en) | 2005-10-25 | 2011-12-13 | Voyage Medical, Inc. | Flow reduction hood systems |
US7930016B1 (en) | 2005-02-02 | 2011-04-19 | Voyage Medical, Inc. | Tissue closure system |
US7918787B2 (en) | 2005-02-02 | 2011-04-05 | Voyage Medical, Inc. | Tissue visualization and manipulation systems |
US8050746B2 (en) | 2005-02-02 | 2011-11-01 | Voyage Medical, Inc. | Tissue visualization device and method variations |
US11478152B2 (en) | 2005-02-02 | 2022-10-25 | Intuitive Surgical Operations, Inc. | Electrophysiology mapping and visualization system |
US7860556B2 (en) * | 2005-02-02 | 2010-12-28 | Voyage Medical, Inc. | Tissue imaging and extraction systems |
US8137333B2 (en) | 2005-10-25 | 2012-03-20 | Voyage Medical, Inc. | Delivery of biological compounds to ischemic and/or infarcted tissue |
US8221310B2 (en) | 2005-10-25 | 2012-07-17 | Voyage Medical, Inc. | Tissue visualization device and method variations |
US7749249B2 (en) | 2006-02-21 | 2010-07-06 | Kardium Inc. | Method and device for closing holes in tissue |
US8628520B2 (en) * | 2006-05-02 | 2014-01-14 | Biosense Webster, Inc. | Catheter with omni-directional optical lesion evaluation |
WO2007136591A1 (en) * | 2006-05-15 | 2007-11-29 | Baystate Health, Inc. | Balloon endoscope device |
US20070270688A1 (en) * | 2006-05-19 | 2007-11-22 | Daniel Gelbart | Automatic atherectomy system |
US9055906B2 (en) | 2006-06-14 | 2015-06-16 | Intuitive Surgical Operations, Inc. | In-vivo visualization systems |
US10028783B2 (en) | 2006-06-28 | 2018-07-24 | Kardium Inc. | Apparatus and method for intra-cardiac mapping and ablation |
US8449605B2 (en) | 2006-06-28 | 2013-05-28 | Kardium Inc. | Method for anchoring a mitral valve |
US11389232B2 (en) | 2006-06-28 | 2022-07-19 | Kardium Inc. | Apparatus and method for intra-cardiac mapping and ablation |
US9119633B2 (en) | 2006-06-28 | 2015-09-01 | Kardium Inc. | Apparatus and method for intra-cardiac mapping and ablation |
US8920411B2 (en) | 2006-06-28 | 2014-12-30 | Kardium Inc. | Apparatus and method for intra-cardiac mapping and ablation |
US7914434B2 (en) * | 2006-07-03 | 2011-03-29 | Xoft, Inc. | Endoscopic/percutaneous electronic radiation applicator and method of use |
US7837610B2 (en) | 2006-08-02 | 2010-11-23 | Kardium Inc. | System for improving diastolic dysfunction |
US10004388B2 (en) | 2006-09-01 | 2018-06-26 | Intuitive Surgical Operations, Inc. | Coronary sinus cannulation |
US20080097476A1 (en) | 2006-09-01 | 2008-04-24 | Voyage Medical, Inc. | Precision control systems for tissue visualization and manipulation assemblies |
WO2008028149A2 (en) | 2006-09-01 | 2008-03-06 | Voyage Medical, Inc. | Electrophysiology mapping and visualization system |
US8728073B2 (en) * | 2006-10-10 | 2014-05-20 | Biosense Webster, Inc. | Multi-region staged inflation balloon |
US10335131B2 (en) | 2006-10-23 | 2019-07-02 | Intuitive Surgical Operations, Inc. | Methods for preventing tissue migration |
US8986298B2 (en) | 2006-11-17 | 2015-03-24 | Biosense Webster, Inc. | Catheter with omni-directional optical tip having isolated optical paths |
TW200824643A (en) * | 2006-12-13 | 2008-06-16 | Chieh-Hsiao Chen | Guiding stylet apparatus |
US20080183036A1 (en) | 2006-12-18 | 2008-07-31 | Voyage Medical, Inc. | Systems and methods for unobstructed visualization and ablation |
US8131350B2 (en) | 2006-12-21 | 2012-03-06 | Voyage Medical, Inc. | Stabilization of visualization catheters |
US8758229B2 (en) | 2006-12-21 | 2014-06-24 | Intuitive Surgical Operations, Inc. | Axial visualization systems |
US20080234572A1 (en) * | 2007-03-23 | 2008-09-25 | Civco Medical Instruments Co., Inc. | Fiducial marker with absorbable connecting sleeve and absorbable spacer for imaging localization |
WO2008134457A1 (en) | 2007-04-27 | 2008-11-06 | Voyage Medical, Inc. | Complex shape steerable tissue visualization and manipulation catheter |
US8657805B2 (en) | 2007-05-08 | 2014-02-25 | Intuitive Surgical Operations, Inc. | Complex shape steerable tissue visualization and manipulation catheter |
US8709008B2 (en) | 2007-05-11 | 2014-04-29 | Intuitive Surgical Operations, Inc. | Visual electrode ablation systems |
US7835074B2 (en) | 2007-06-05 | 2010-11-16 | Sterling Lc | Mini-scope for multi-directional imaging |
US20090030276A1 (en) * | 2007-07-27 | 2009-01-29 | Voyage Medical, Inc. | Tissue visualization catheter with imaging systems integration |
US20090062790A1 (en) * | 2007-08-31 | 2009-03-05 | Voyage Medical, Inc. | Direct visualization bipolar ablation systems |
US8235985B2 (en) | 2007-08-31 | 2012-08-07 | Voyage Medical, Inc. | Visualization and ablation system variations |
US8500730B2 (en) * | 2007-11-16 | 2013-08-06 | Biosense Webster, Inc. | Catheter with omni-directional optical tip having isolated optical paths |
US8906011B2 (en) | 2007-11-16 | 2014-12-09 | Kardium Inc. | Medical device for use in bodily lumens, for example an atrium |
US9572583B2 (en) | 2007-11-21 | 2017-02-21 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Methods and systems for occluding vessels during cardiac ablation |
WO2009091807A1 (en) * | 2008-01-14 | 2009-07-23 | Veryst Engineering Llc | Apparatus for in vivo energy harvesting |
US8489172B2 (en) * | 2008-01-25 | 2013-07-16 | Kardium Inc. | Liposuction system |
US8858609B2 (en) | 2008-02-07 | 2014-10-14 | Intuitive Surgical Operations, Inc. | Stent delivery under direct visualization |
US20090287304A1 (en) | 2008-05-13 | 2009-11-19 | Kardium Inc. | Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve |
US20090287048A1 (en) * | 2008-05-16 | 2009-11-19 | Sterling Lc | Method and apparatus for imaging within a living body |
CN102137616B (en) | 2008-06-18 | 2014-09-10 | 雷神公司 | Transparent endoscope head defining a focal length |
US20090326321A1 (en) * | 2008-06-18 | 2009-12-31 | Jacobsen Stephen C | Miniaturized Imaging Device Including Multiple GRIN Lenses Optically Coupled to Multiple SSIDs |
US9101735B2 (en) | 2008-07-07 | 2015-08-11 | Intuitive Surgical Operations, Inc. | Catheter control systems |
WO2010014792A2 (en) * | 2008-07-30 | 2010-02-04 | Sterling Lc | Method and device for incremental wavelength variation to analyze tissue |
EP2163218A1 (en) * | 2008-09-16 | 2010-03-17 | Osyris Medical | Device for treating part of a human or animal body comprising an instrument for dispensing and/or an instrument for locally sucking up treatment doses and means for controlling dosimetry |
US8894643B2 (en) | 2008-10-10 | 2014-11-25 | Intuitive Surgical Operations, Inc. | Integral electrode placement and connection systems |
US8333012B2 (en) | 2008-10-10 | 2012-12-18 | Voyage Medical, Inc. | Method of forming electrode placement and connection systems |
US9060704B2 (en) * | 2008-11-04 | 2015-06-23 | Sarcos Lc | Method and device for wavelength shifted imaging |
US9795442B2 (en) | 2008-11-11 | 2017-10-24 | Shifamed Holdings, Llc | Ablation catheters |
US9468364B2 (en) | 2008-11-14 | 2016-10-18 | Intuitive Surgical Operations, Inc. | Intravascular catheter with hood and image processing systems |
US8717428B2 (en) | 2009-10-01 | 2014-05-06 | Raytheon Company | Light diffusion apparatus |
WO2011041728A2 (en) | 2009-10-01 | 2011-04-07 | Jacobsen Stephen C | Needle delivered imaging device |
US9144664B2 (en) | 2009-10-01 | 2015-09-29 | Sarcos Lc | Method and apparatus for manipulating movement of a micro-catheter |
EP2482749B1 (en) | 2009-10-01 | 2017-08-30 | Kardium Inc. | Kit for constricting tissue or a bodily orifice, for example, a mitral valve |
US8696653B2 (en) * | 2009-10-02 | 2014-04-15 | Cardiofocus, Inc. | Cardiac ablation system with pulsed aiming light |
WO2011041635A2 (en) * | 2009-10-02 | 2011-04-07 | Cardiofocus, Inc. | Cardiac ablation system with inflatable member having multiple inflation settings |
WO2011041638A2 (en) * | 2009-10-02 | 2011-04-07 | Cardiofocus, Inc. | Cardiac ablation system with automatic safety shut-off feature |
WO2011044248A2 (en) * | 2009-10-06 | 2011-04-14 | Cardiofocus, Inc. | Cardiac ablation image analysis system and process |
US8828028B2 (en) | 2009-11-03 | 2014-09-09 | Raytheon Company | Suture device and method for closing a planar opening |
US8694071B2 (en) | 2010-02-12 | 2014-04-08 | Intuitive Surgical Operations, Inc. | Image stabilization techniques and methods |
WO2011111645A1 (en) * | 2010-03-09 | 2011-09-15 | 学校法人慶應義塾 | System for preventing burning and sticking of blood on laser catheter output part |
US9814522B2 (en) | 2010-04-06 | 2017-11-14 | Intuitive Surgical Operations, Inc. | Apparatus and methods for ablation efficacy |
US9655677B2 (en) | 2010-05-12 | 2017-05-23 | Shifamed Holdings, Llc | Ablation catheters including a balloon and electrodes |
EP2568905A4 (en) | 2010-05-12 | 2017-07-26 | Shifamed Holdings, LLC | Low profile electrode assembly |
US8940002B2 (en) | 2010-09-30 | 2015-01-27 | Kardium Inc. | Tissue anchor system |
JP2012147937A (en) * | 2011-01-19 | 2012-08-09 | Sony Corp | Laser therapy apparatus, laser therapy system and assessment method |
US11259867B2 (en) | 2011-01-21 | 2022-03-01 | Kardium Inc. | High-density electrode-based medical device system |
US9452016B2 (en) | 2011-01-21 | 2016-09-27 | Kardium Inc. | Catheter system |
US9480525B2 (en) | 2011-01-21 | 2016-11-01 | Kardium, Inc. | High-density electrode-based medical device system |
CA2764494A1 (en) | 2011-01-21 | 2012-07-21 | Kardium Inc. | Enhanced medical device for use in bodily cavities, for example an atrium |
US9943360B2 (en) | 2011-01-30 | 2018-04-17 | University Health Network | Coil electrode for thermal therapy |
US9072511B2 (en) | 2011-03-25 | 2015-07-07 | Kardium Inc. | Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve |
USD777925S1 (en) | 2012-01-20 | 2017-01-31 | Kardium Inc. | Intra-cardiac procedure device |
USD777926S1 (en) | 2012-01-20 | 2017-01-31 | Kardium Inc. | Intra-cardiac procedure device |
US10827977B2 (en) | 2012-05-21 | 2020-11-10 | Kardium Inc. | Systems and methods for activating transducers |
US9198592B2 (en) | 2012-05-21 | 2015-12-01 | Kardium Inc. | Systems and methods for activating transducers |
US9017321B2 (en) | 2012-05-21 | 2015-04-28 | Kardium, Inc. | Systems and methods for activating transducers |
US9770296B2 (en) * | 2012-07-31 | 2017-09-26 | Katalyst Surgical, Llc | Steerable laser probe |
US9877867B2 (en) * | 2012-08-01 | 2018-01-30 | Katalyst Surgical, Llc | Steerable laser probe |
US9226855B2 (en) * | 2012-09-06 | 2016-01-05 | Katalyst Surgical, Llc | Steerable laser probe |
US20140257266A1 (en) * | 2013-03-08 | 2014-09-11 | Symple Surgical Inc. | Balloon catheter apparatus with microwave emitter |
US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
JP2016512090A (en) * | 2013-03-13 | 2016-04-25 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Apparatus for tissue separation and related uses |
WO2014146126A1 (en) | 2013-03-15 | 2014-09-18 | Myoscience, Inc. | Cryogenic blunt dissection methods and devices |
US9295512B2 (en) | 2013-03-15 | 2016-03-29 | Myoscience, Inc. | Methods and devices for pain management |
US9610112B2 (en) | 2013-03-15 | 2017-04-04 | Myoscience, Inc. | Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis |
US10349824B2 (en) | 2013-04-08 | 2019-07-16 | Apama Medical, Inc. | Tissue mapping and visualization systems |
US10098694B2 (en) | 2013-04-08 | 2018-10-16 | Apama Medical, Inc. | Tissue ablation and monitoring thereof |
CA2908517A1 (en) * | 2013-04-08 | 2014-10-16 | Apama Medical, Inc. | Cardiac ablation catheters and methods of use thereof |
EP3137007A4 (en) * | 2014-04-28 | 2017-09-27 | Cardiofocus, Inc. | System and method for visualizing tissue with an icg dye composition during ablation procedures |
US10368936B2 (en) | 2014-11-17 | 2019-08-06 | Kardium Inc. | Systems and methods for selecting, activating, or selecting and activating transducers |
US10722184B2 (en) | 2014-11-17 | 2020-07-28 | Kardium Inc. | Systems and methods for selecting, activating, or selecting and activating transducers |
WO2016089900A2 (en) | 2014-12-03 | 2016-06-09 | Cardiofocus, Inc. | System and method for visual confirmation of pulmonary vein isolation during ablation procedures |
CN107920723B (en) * | 2015-06-26 | 2020-01-10 | 阿帕玛医疗公司 | Tissue mapping and visualization system |
EP4302713A3 (en) | 2015-11-16 | 2024-03-13 | Boston Scientific Scimed, Inc. | Energy delivery devices |
EP3368156B1 (en) * | 2015-12-10 | 2020-02-12 | St. Jude Medical, Cardiology Division, Inc. | Blood vessel isolation ablation device |
US10702163B2 (en) | 2016-05-03 | 2020-07-07 | Precision EP GmbH | Systems and methods for intracavitary temperature measurement and monitoring |
WO2018128644A1 (en) * | 2017-01-09 | 2018-07-12 | Scott Koss | Trans-ventricular introducer sheath with intracardiac/extracardiac stabilization and a suture retention system |
JP2021523814A (en) * | 2018-05-16 | 2021-09-09 | パデュー リサーチ ファウンデイション | Intravascular photoacoustic tomography device and its method |
JP7384814B2 (en) | 2018-10-01 | 2023-11-21 | 株式会社カネカ | Light irradiation medical device |
US11925333B2 (en) | 2019-02-01 | 2024-03-12 | Covidien Lp | System for fluoroscopic tracking of a catheter to update the relative position of a target and the catheter in a 3D model of a luminal network |
WO2020224972A1 (en) | 2019-05-07 | 2020-11-12 | Vascomed Gmbh | Mapping and ablation catheter with multiple loop segments |
US11671691B2 (en) | 2019-06-20 | 2023-06-06 | Cilag Gmbh International | Image rotation in an endoscopic laser mapping imaging system |
US11134832B2 (en) * | 2019-06-20 | 2021-10-05 | Cilag Gmbh International | Image rotation in an endoscopic hyperspectral, fluorescence, and laser mapping imaging system |
US11172811B2 (en) | 2019-06-20 | 2021-11-16 | Cilag Gmbh International | Image rotation in an endoscopic fluorescence imaging system |
US11877065B2 (en) * | 2019-06-20 | 2024-01-16 | Cilag Gmbh International | Image rotation in an endoscopic hyperspectral imaging system |
US11849995B2 (en) * | 2021-02-18 | 2023-12-26 | Biosense Webster (Israel) Ltd. | Detection of balloon catheter tissue contact using optical measurement |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5152759A (en) * | 1989-06-07 | 1992-10-06 | University Of Miami, School Of Medicine, Dept. Of Ophthalmology | Noncontact laser microsurgical apparatus |
US5409483A (en) * | 1993-01-22 | 1995-04-25 | Jeffrey H. Reese | Direct visualization surgical probe |
Family Cites Families (230)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3417745A (en) | 1963-08-23 | 1968-12-24 | Sheldon Edward Emanuel | Fiber endoscope provided with focusing means and electroluminescent means |
US3821510A (en) | 1973-02-22 | 1974-06-28 | H Muncheryan | Hand held laser instrumentation device |
GB1485908A (en) | 1974-05-21 | 1977-09-14 | Nath G | Apparatus for applying light radiation |
US4273109A (en) | 1976-07-06 | 1981-06-16 | Cavitron Corporation | Fiber optic light delivery apparatus and medical instrument utilizing same |
US4224929A (en) | 1977-11-08 | 1980-09-30 | Olympus Optical Co., Ltd. | Endoscope with expansible cuff member and operation section |
US4336809A (en) | 1980-03-17 | 1982-06-29 | Burleigh Instruments, Inc. | Human and animal tissue photoradiation system and method |
US4445892A (en) | 1982-05-06 | 1984-05-01 | Laserscope, Inc. | Dual balloon catheter device |
NZ205144A (en) | 1982-08-26 | 1987-03-06 | Kei Mori | Light guide with diffusing strip |
USRE34544E (en) | 1982-11-23 | 1994-02-15 | The Beth Israel Hospital Association | Method of treatment of artherosclerosis and balloon catheter the same |
US4701166A (en) | 1983-05-03 | 1987-10-20 | Catheter Technology Corp. | Valved two-way catheter |
JPS6131142A (en) | 1984-07-25 | 1986-02-13 | 富士写真光機株式会社 | Blood vessel anastomosis laser probe |
US5188632A (en) | 1984-12-07 | 1993-02-23 | Advanced Interventional Systems, Inc. | Guidance and delivery system for high-energy pulsed laser light |
US4913142A (en) | 1985-03-22 | 1990-04-03 | Massachusetts Institute Of Technology | Catheter for laser angiosurgery |
US5104392A (en) | 1985-03-22 | 1992-04-14 | Massachusetts Institute Of Technology | Laser spectro-optic imaging for diagnosis and treatment of diseased tissue |
US4718417A (en) | 1985-03-22 | 1988-01-12 | Massachusetts Institute Of Technology | Visible fluorescence spectral diagnostic for laser angiosurgery |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
US5693043A (en) | 1985-03-22 | 1997-12-02 | Massachusetts Institute Of Technology | Catheter for laser angiosurgery |
US4660925A (en) | 1985-04-29 | 1987-04-28 | Laser Therapeutics, Inc. | Apparatus for producing a cylindrical pattern of light and method of manufacture |
US4862886A (en) | 1985-05-08 | 1989-09-05 | Summit Technology Inc. | Laser angioplasty |
US4917084A (en) | 1985-07-31 | 1990-04-17 | C. R. Bard, Inc. | Infrared laser catheter system |
EP0214712B1 (en) | 1985-07-31 | 1992-09-02 | C.R. Bard, Inc. | Infrared laser catheter apparatus |
US4819632A (en) | 1986-05-19 | 1989-04-11 | Davies David H | Retrolasing catheter and method |
JPH0718480B2 (en) * | 1986-08-18 | 1995-03-06 | 本田技研工業株式会社 | Differential |
US4860743A (en) | 1986-10-27 | 1989-08-29 | University Of Florida | Laser method and apparatus for the recanalization of vessels and the treatment of other cardiac conditions |
US4961738A (en) | 1987-01-28 | 1990-10-09 | Mackin Robert A | Angioplasty catheter with illumination and visualization within angioplasty balloon |
US5090959A (en) | 1987-04-30 | 1992-02-25 | Advanced Cardiovascular Systems, Inc. | Imaging balloon dilatation catheter |
DE3878485D1 (en) | 1987-05-25 | 1993-03-25 | Deutsche Aerospace | DEVICE FOR CIRCUMFERENTIAL RADIATION OF OBJECTS. |
EP0292621B1 (en) | 1987-05-26 | 1994-12-14 | Surgical Laser Technologies, Inc. | Contact or insertion laser probe having wide angle radiation |
US4770653A (en) | 1987-06-25 | 1988-09-13 | Medilase, Inc. | Laser angioplasty |
IT1220172B (en) | 1987-07-17 | 1990-06-06 | Il Consiglio Nazionale Delle R | FIBER OPTIC DEVICE FOR THE TRANSMISSION AND LATERAL IRRADIATION OF LASER ENERGY, PARTICULARLY FOR ANGIOPLASTIC TREATMENTS |
US4781681A (en) | 1987-09-15 | 1988-11-01 | Gv Medical, Inc. | Inflatable tip for laser catheterization |
US4878492A (en) | 1987-10-08 | 1989-11-07 | C. R. Bard, Inc. | Laser balloon catheter |
US4852567A (en) | 1988-01-21 | 1989-08-01 | C. R. Bard, Inc. | Laser tipped catheter |
US5026367A (en) | 1988-03-18 | 1991-06-25 | Cardiovascular Laser Systems, Inc. | Laser angioplasty catheter and a method for use thereof |
US5242437A (en) | 1988-06-10 | 1993-09-07 | Trimedyne Laser Systems, Inc. | Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium |
US5125925A (en) | 1988-08-03 | 1992-06-30 | Photoradiation Systems | Intracavity laser catheter with sensing fiber |
US6066130A (en) | 1988-10-24 | 2000-05-23 | The General Hospital Corporation | Delivering laser energy |
US5140987A (en) | 1989-03-17 | 1992-08-25 | Wayne State University | Method for transvenous ablation of cardiac electrically conductive tissue by laser photocoagulation |
JP2882814B2 (en) | 1989-08-24 | 1999-04-12 | 株式会社エス・エル・ティ・ジャパン | Laser irradiation equipment |
JP3069108B2 (en) | 1989-09-01 | 2000-07-24 | 株式会社エス・エル・ティ・ジャパン | Laser light emitting device |
US5109859A (en) | 1989-10-04 | 1992-05-05 | Beth Israel Hospital Association | Ultrasound guided laser angioplasty |
US5078681A (en) | 1989-10-23 | 1992-01-07 | Olympus Optical Co., Ltd. | Balloon catheter apparatus with releasable distal seal and method of operation |
US5207699A (en) | 1989-10-30 | 1993-05-04 | Coe Frederick L | Lancet handling and disposal assembly |
US5030201A (en) | 1989-11-24 | 1991-07-09 | Aubrey Palestrant | Expandable atherectomy catheter device |
EP0437183B1 (en) | 1990-01-09 | 1994-07-27 | Ciba-Geigy Ag | Light diffuser for a photodynamic therapy of tumours in the oesophagus of a patient |
ES2067013T3 (en) | 1990-01-09 | 1995-03-16 | Ciba Geigy Ag | DEVICE FOR THE IRRADIATION OF THE BRONCHI OF A PATIENT FOR A PHOTODYNAMIC THERAPY. |
US5261904A (en) | 1990-01-30 | 1993-11-16 | C. R. Bard, Inc. | Laser catheter having diffraction grating for beam shaping |
US5133709A (en) | 1990-02-23 | 1992-07-28 | Prince Martin R | Optical fiber with atraumatic rounded end for use in laser angioplasty |
US5725522A (en) | 1990-06-15 | 1998-03-10 | Rare Earth Medical, Inc. | Laser suturing of biological materials |
US5071417A (en) | 1990-06-15 | 1991-12-10 | Rare Earth Medical Lasers, Inc. | Laser fusion of biological materials |
US5188634A (en) | 1990-07-13 | 1993-02-23 | Trimedyne, Inc. | Rotatable laser probe with beveled tip |
US5053033A (en) | 1990-10-10 | 1991-10-01 | Boston Advanced Technologies, Inc. | Inhibition of restenosis by ultraviolet radiation |
US5269777A (en) | 1990-11-01 | 1993-12-14 | Pdt Systems, Inc. | Diffusion tip for optical fibers |
US5380316A (en) | 1990-12-18 | 1995-01-10 | Advanced Cardiovascular Systems, Inc. | Method for intra-operative myocardial device revascularization |
DE9116216U1 (en) | 1990-12-19 | 1992-05-27 | Fa. Carl Zeiss, 7920 Heidenheim, De | |
US5531664A (en) | 1990-12-26 | 1996-07-02 | Olympus Optical Co., Ltd. | Bending actuator having a coil sheath with a fixed distal end and a free proximal end |
JP3041099B2 (en) | 1991-02-01 | 2000-05-15 | オリンパス光学工業株式会社 | Electronic endoscope device |
US5163935A (en) | 1991-02-20 | 1992-11-17 | Reliant Laser Corporation | Surgical laser endoscopic focusing guide with an optical fiber link |
US5151096A (en) | 1991-03-28 | 1992-09-29 | Angiolaz, Incorporated | Laser catheter diffuser |
AU1870592A (en) | 1991-04-05 | 1992-11-02 | Indigo Medical, Incorporated | Apparatus using a laser lucent needle |
US5242438A (en) | 1991-04-22 | 1993-09-07 | Trimedyne, Inc. | Method and apparatus for treating a body site with laterally directed laser radiation |
US5190538A (en) | 1991-04-22 | 1993-03-02 | Trimedyne, Inc. | Method and apparatus for subjecting a body site to a movable beam of laterally directed laser radiation |
US5169395A (en) | 1991-04-26 | 1992-12-08 | Pdt Cardiovascular, Inc. | Laser delivery system |
US5968039A (en) | 1991-10-03 | 1999-10-19 | Essential Dental Systems, Inc. | Laser device for performing canal surgery in narrow channels |
US5605162A (en) | 1991-10-15 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Method for using a variable stiffness guidewire |
US5196005A (en) | 1991-11-26 | 1993-03-23 | Pdt Systems, Inc. | Continuous gradient cylindrical diffusion tip for optical fibers and method for making |
US5437660A (en) | 1991-12-30 | 1995-08-01 | Trimedyne, Inc. | Tissue ablation and a lateral-lasing fiber optic device therefor |
US5395362A (en) | 1992-01-14 | 1995-03-07 | Summit Technology | Methods and apparatus for distributing laser radiation |
WO1993015676A1 (en) | 1992-02-05 | 1993-08-19 | Angelase, Inc. | Laser catheter with movable integral fixation wire |
US5830209A (en) | 1992-02-05 | 1998-11-03 | Angeion Corporation | Multi-fiber laser catheter |
DE4237286A1 (en) | 1992-04-06 | 1994-05-05 | Laser Medizin Zentrum Ggmbh Be | Method and device for increasing the efficiency of an optical work shaft for photo-thermotherapy |
JPH05307139A (en) * | 1992-04-28 | 1993-11-19 | Olympus Optical Co Ltd | Endoscope objective |
US5324284A (en) | 1992-06-05 | 1994-06-28 | Cardiac Pathways, Inc. | Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method |
EP0644742B1 (en) | 1992-06-12 | 1999-12-08 | Miravant Systems, Inc. | Diffusor tip for an optical fiber |
US5772590A (en) | 1992-06-30 | 1998-06-30 | Cordis Webster, Inc. | Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire |
US5782239A (en) | 1992-06-30 | 1998-07-21 | Cordis Webster, Inc. | Unique electrode configurations for cardiovascular electrode catheter with built-in deflection method and central puller wire |
US5292320A (en) | 1992-07-06 | 1994-03-08 | Ceramoptec, Inc. | Radial medical laser delivery device |
US6086581A (en) | 1992-09-29 | 2000-07-11 | Ep Technologies, Inc. | Large surface cardiac ablation catheter that assumes a low profile during introduction into the heart |
US5700243A (en) * | 1992-10-30 | 1997-12-23 | Pdt Systems, Inc. | Balloon perfusion catheter |
US5368564A (en) | 1992-12-23 | 1994-11-29 | Angeion Corporation | Steerable catheter |
IT1266217B1 (en) | 1993-01-18 | 1996-12-27 | Xtrode Srl | ELECTROCATHETER FOR MAPPING AND INTERVENTION ON HEART CAVITIES. |
US5337381A (en) | 1993-01-21 | 1994-08-09 | Fiberguide Industries | Fiber optic cylindrical diffuser |
US5417653A (en) | 1993-01-21 | 1995-05-23 | Sahota; Harvinder | Method for minimizing restenosis |
US6161543A (en) | 1993-02-22 | 2000-12-19 | Epicor, Inc. | Methods of epicardial ablation for creating a lesion around the pulmonary veins |
US5350375A (en) | 1993-03-15 | 1994-09-27 | Yale University | Methods for laser induced fluorescence intensity feedback control during laser angioplasty |
US5344419A (en) | 1993-04-23 | 1994-09-06 | Wayne State University | Apparatus and method for making a diffusing tip in a balloon catheter system |
DE69412474T2 (en) | 1993-04-28 | 1998-12-17 | Focal Inc | DEVICE, PRODUCT AND USE REGARDING INTRALUMINAL PHOTOTHERMO MOLDING |
DE4403134A1 (en) | 1993-05-14 | 1995-08-03 | Laser Medizin Zentrum Ggmbh Be | Combination device for thermal obliteration of biological tissue |
CA2165829A1 (en) | 1993-07-01 | 1995-01-19 | John E. Abele | Imaging, electrical potential sensing, and ablation catheters |
US5630837A (en) | 1993-07-01 | 1997-05-20 | Boston Scientific Corporation | Acoustic ablation |
US5860974A (en) | 1993-07-01 | 1999-01-19 | Boston Scientific Corporation | Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft |
US5445608A (en) | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
US5807395A (en) | 1993-08-27 | 1998-09-15 | Medtronic, Inc. | Method and apparatus for RF ablation and hyperthermia |
US5464404A (en) | 1993-09-20 | 1995-11-07 | Abela Laser Systems, Inc. | Cardiac ablation catheters and method |
US5545209A (en) | 1993-09-30 | 1996-08-13 | Texas Petrodet, Inc. | Controlled deployment of a medical device |
US6146379A (en) | 1993-10-15 | 2000-11-14 | Ep Technologies, Inc. | Systems and methods for creating curvilinear lesions in body tissue |
US5427119A (en) | 1993-11-03 | 1995-06-27 | Daig Corporation | Guiding introducer for right atrium |
US5497774A (en) | 1993-11-03 | 1996-03-12 | Daig Corporation | Guiding introducer for left atrium |
US5575766A (en) | 1993-11-03 | 1996-11-19 | Daig Corporation | Process for the nonsurgical mapping and treatment of atrial arrhythmia using catheters guided by shaped guiding introducers |
US5363458A (en) | 1994-02-28 | 1994-11-08 | Fiber Guide Industries | Fiber optic light diffuser |
DK0676218T3 (en) | 1994-03-25 | 2002-10-07 | Novartis Ag | Light diffuses and methods of making them |
US6056744A (en) | 1994-06-24 | 2000-05-02 | Conway Stuart Medical, Inc. | Sphincter treatment apparatus |
US5680860A (en) | 1994-07-07 | 1997-10-28 | Cardiac Pathways Corporation | Mapping and/or ablation catheter with coilable distal extremity and method for using same |
US6090084A (en) | 1994-07-08 | 2000-07-18 | Daig Corporation | Shaped guiding introducers for use with a catheter for the treatment of atrial arrhythmia |
US5690611A (en) | 1994-07-08 | 1997-11-25 | Daig Corporation | Process for the treatment of atrial arrhythima using a catheter guided by shaped giding introducers |
US5431647A (en) | 1994-07-13 | 1995-07-11 | Pioneer Optics Company | Fiberoptic cylindrical diffuser |
US5441497A (en) | 1994-07-14 | 1995-08-15 | Pdt Cardiovascular, Inc. | Light diffusing guidewire |
DE9411754U1 (en) | 1994-07-20 | 1994-11-10 | Goebel Dieter Dr | Laser awl for the treatment of osteochondritis deformans |
US5908415A (en) | 1994-09-09 | 1999-06-01 | Rare Earth Medical, Inc. | Phototherapy methods and apparatus |
US6579285B2 (en) | 1994-09-09 | 2003-06-17 | Cardiofocus, Inc. | Photoablation with infrared radiation |
US6572609B1 (en) | 1999-07-14 | 2003-06-03 | Cardiofocus, Inc. | Phototherapeutic waveguide apparatus |
US6102905A (en) | 1994-09-09 | 2000-08-15 | Cardiofocus, Inc. | Phototherapy device including housing for an optical element and method of making |
US8025661B2 (en) | 1994-09-09 | 2011-09-27 | Cardiofocus, Inc. | Coaxial catheter instruments for ablation with radiant energy |
US6270492B1 (en) | 1994-09-09 | 2001-08-07 | Cardiofocus, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
US6676656B2 (en) | 1994-09-09 | 2004-01-13 | Cardiofocus, Inc. | Surgical ablation with radiant energy |
US6423055B1 (en) | 1999-07-14 | 2002-07-23 | Cardiofocus, Inc. | Phototherapeutic wave guide apparatus |
CA2199384C (en) | 1994-09-09 | 2006-06-06 | Edward L. Sinofsky | Phototherapeutic apparatus |
US5947959A (en) | 1994-09-09 | 1999-09-07 | Rare Earth Medical, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
US5643253A (en) | 1995-06-06 | 1997-07-01 | Rare Earth Medical, Inc. | Phototherapy apparatus with integral stopper device |
US6558375B1 (en) | 2000-07-14 | 2003-05-06 | Cardiofocus, Inc. | Cardiac ablation instrument |
US5885278A (en) | 1994-10-07 | 1999-03-23 | E.P. Technologies, Inc. | Structures for deploying movable electrode elements |
US5722401A (en) | 1994-10-19 | 1998-03-03 | Cardiac Pathways Corporation | Endocardial mapping and/or ablation catheter probe |
US5613965A (en) | 1994-12-08 | 1997-03-25 | Summit Technology Inc. | Corneal reprofiling using an annular beam of ablative radiation |
US5715832A (en) | 1995-02-28 | 1998-02-10 | Boston Scientific Corporation | Deflectable biopsy catheter |
AU5558096A (en) | 1995-05-01 | 1996-11-21 | Medtronic Cardiorhythm | Dual curve ablation catheter and method |
EP0836499A1 (en) | 1995-06-07 | 1998-04-22 | Cardima, Inc. | Guiding catheter for coronary sinus |
US5702438A (en) | 1995-06-08 | 1997-12-30 | Avitall; Boaz | Expandable recording and ablation catheter system |
EP0835075A4 (en) * | 1995-06-30 | 1999-06-23 | Boston Scient Corp | Ultrasound imaging catheter with a cutting element |
US5824005A (en) | 1995-08-22 | 1998-10-20 | Board Of Regents, The University Of Texas System | Maneuverable electrophysiology catheter for percutaneous or intraoperative ablation of cardiac arrhythmias |
US5823955A (en) | 1995-11-20 | 1998-10-20 | Medtronic Cardiorhythm | Atrioventricular valve tissue ablation catheter and method |
KR0166937B1 (en) | 1995-12-29 | 1999-02-01 | 구자홍 | Shg device |
US5925038A (en) | 1996-01-19 | 1999-07-20 | Ep Technologies, Inc. | Expandable-collapsible electrode structures for capacitive coupling to tissue |
US5769843A (en) | 1996-02-20 | 1998-06-23 | Cormedica | Percutaneous endomyocardial revascularization |
US5800482A (en) | 1996-03-06 | 1998-09-01 | Cardiac Pathways Corporation | Apparatus and method for linear lesion ablation |
US5891133A (en) | 1996-03-29 | 1999-04-06 | Eclipse Surgical Technologies, Inc. | Apparatus for laser-assisted intra-coronary transmyocardial revascularization and other applications |
US6458096B1 (en) | 1996-04-01 | 2002-10-01 | Medtronic, Inc. | Catheter with autoinflating, autoregulating balloon |
US5773835A (en) | 1996-06-07 | 1998-06-30 | Rare Earth Medical, Inc. | Fiber optic spectroscopy |
US6126682A (en) | 1996-08-13 | 2000-10-03 | Oratec Interventions, Inc. | Method for treating annular fissures in intervertebral discs |
US5833682A (en) | 1996-08-26 | 1998-11-10 | Illumenex Corporation | Light delivery system with blood flushing capability |
US5891134A (en) | 1996-09-24 | 1999-04-06 | Goble; Colin | System and method for applying thermal energy to tissue |
US5931834A (en) | 1996-10-15 | 1999-08-03 | Eclipse Surgical Technologies, Inc. | Method for non-synchronous laser-assisted myocardial revascularization |
US5741249A (en) | 1996-10-16 | 1998-04-21 | Fidus Medical Technology Corporation | Anchoring tip assembly for microwave ablation catheter |
US6311692B1 (en) | 1996-10-22 | 2001-11-06 | Epicor, Inc. | Apparatus and method for diagnosis and therapy of electrophysiological disease |
US6237605B1 (en) | 1996-10-22 | 2001-05-29 | Epicor, Inc. | Methods of epicardial ablation |
US5904651A (en) | 1996-10-28 | 1999-05-18 | Ep Technologies, Inc. | Systems and methods for visualizing tissue during diagnostic or therapeutic procedures |
US5845646A (en) | 1996-11-05 | 1998-12-08 | Lemelson; Jerome | System and method for treating select tissue in a living being |
US6071279A (en) | 1996-12-19 | 2000-06-06 | Ep Technologies, Inc. | Branched structures for supporting multiple electrode elements |
US6024740A (en) | 1997-07-08 | 2000-02-15 | The Regents Of The University Of California | Circumferential ablation device assembly |
US5971983A (en) | 1997-05-09 | 1999-10-26 | The Regents Of The University Of California | Tissue ablation device and method of use |
US6012457A (en) | 1997-07-08 | 2000-01-11 | The Regents Of The University Of California | Device and method for forming a circumferential conduction block in a pulmonary vein |
US6251109B1 (en) | 1997-06-27 | 2001-06-26 | Daig Corporation | Process and device for the treatment of atrial arrhythmia |
US5938660A (en) | 1997-06-27 | 1999-08-17 | Daig Corporation | Process and device for the treatment of atrial arrhythmia |
US6117101A (en) | 1997-07-08 | 2000-09-12 | The Regents Of The University Of California | Circumferential ablation device assembly |
US6245064B1 (en) | 1997-07-08 | 2001-06-12 | Atrionix, Inc. | Circumferential ablation device assembly |
US6514249B1 (en) | 1997-07-08 | 2003-02-04 | Atrionix, Inc. | Positioning system and method for orienting an ablation element within a pulmonary vein ostium |
US6500174B1 (en) | 1997-07-08 | 2002-12-31 | Atrionix, Inc. | Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member |
US6164283A (en) | 1997-07-08 | 2000-12-26 | The Regents Of The University Of California | Device and method for forming a circumferential conduction block in a pulmonary vein |
US6652515B1 (en) | 1997-07-08 | 2003-11-25 | Atrionix, Inc. | Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall |
US6117071A (en) * | 1997-07-29 | 2000-09-12 | Asahi Kogaku Kogyo Kabushiki Kaisha | Endoscope with movable imaging unit for zooming or focusing |
US6554794B1 (en) | 1997-09-24 | 2003-04-29 | Richard L. Mueller | Non-deforming deflectable multi-lumen catheter |
US5995875A (en) | 1997-10-01 | 1999-11-30 | United States Surgical | Apparatus for thermal treatment of tissue |
US6217510B1 (en) | 1997-10-02 | 2001-04-17 | Olympus Optical Co., Ltd. | Endoscopes and endoscope devices which image regular observation images and fluorescent images as well as which provide easier operation of treatment tools |
US6120496A (en) | 1998-05-05 | 2000-09-19 | Scimed Life Systems, Inc. | Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and coupling device for use with same |
US6071281A (en) | 1998-05-05 | 2000-06-06 | Ep Technologies, Inc. | Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and remote power control unit for use with same |
EP1049951A1 (en) | 1997-12-22 | 2000-11-08 | Micrus Corporation | Variable stiffness fiber optic shaft |
US6251092B1 (en) | 1997-12-30 | 2001-06-26 | Medtronic, Inc. | Deflectable guiding catheter |
US6071302A (en) | 1997-12-31 | 2000-06-06 | Cardiofocus, Inc. | Phototherapeutic apparatus for wide-angle diffusion |
US6423058B1 (en) | 1998-02-19 | 2002-07-23 | Curon Medical, Inc. | Assemblies to visualize and treat sphincters and adjoining tissue regions |
US6064902A (en) | 1998-04-16 | 2000-05-16 | C.R. Bard, Inc. | Pulmonary vein ablation catheter |
US6562020B1 (en) | 1998-07-15 | 2003-05-13 | Corazon Technologies, Inc. | Kits for use in the treatment of vascular calcified lesions |
US6106515A (en) | 1998-08-13 | 2000-08-22 | Intraluminal Therapeutics, Inc. | Expandable laser catheter |
AU1442500A (en) | 1998-10-05 | 2000-04-26 | Scimed Life Systems, Inc. | Large area thermal ablation |
US6245062B1 (en) | 1998-10-23 | 2001-06-12 | Afx, Inc. | Directional reflector shield assembly for a microwave ablation instrument |
US6352531B1 (en) | 1999-03-24 | 2002-03-05 | Micrus Corporation | Variable stiffness optical fiber shaft |
US6325797B1 (en) | 1999-04-05 | 2001-12-04 | Medtronic, Inc. | Ablation catheter and method for isolating a pulmonary vein |
ATE353001T1 (en) | 1999-05-11 | 2007-02-15 | Atrionix Inc | BALLOON ANCHORING WIRE |
US9033961B2 (en) | 1999-07-14 | 2015-05-19 | Cardiofocus, Inc. | Cardiac ablation catheters for forming overlapping lesions |
US20050222558A1 (en) | 1999-07-14 | 2005-10-06 | Cardiofocus, Inc. | Methods of cardiac ablation employing a deflectable sheath catheter |
US20050234437A1 (en) | 1999-07-14 | 2005-10-20 | Cardiofocus, Inc. | Deflectable sheath catheters with out-of-plane bent tip |
US7935108B2 (en) | 1999-07-14 | 2011-05-03 | Cardiofocus, Inc. | Deflectable sheath catheters |
US20050234436A1 (en) | 1999-07-14 | 2005-10-20 | Cardiofocus, Inc. | Methods of cardiac ablation in the vicinity of the right inferior pulmonary vein |
US8900219B2 (en) | 1999-07-14 | 2014-12-02 | Cardiofocus, Inc. | System and method for visualizing tissue during ablation procedures |
US8540704B2 (en) | 1999-07-14 | 2013-09-24 | Cardiofocus, Inc. | Guided cardiac ablation catheters |
US6530921B1 (en) | 1999-07-30 | 2003-03-11 | Terumo Kabushiki Kaisha | Laser irradiation apparatus |
WO2001013812A1 (en) | 1999-08-25 | 2001-03-01 | Cardiofocus, Inc. | Maneuverable optical fiber device for cardiac photoablation |
US6702780B1 (en) | 1999-09-08 | 2004-03-09 | Super Dimension Ltd. | Steering configuration for catheter with rigid distal device |
FR2798371B1 (en) | 1999-09-10 | 2001-11-23 | Acemo | DEVICE FOR PROVIDING THE TRANSFER OF MATERIALS FROM A DEPRESSED PART TO AN OVERPRESSED PART OF A PNEUMATIC CONVEYOR |
US6579279B1 (en) | 1999-09-24 | 2003-06-17 | Omnisonics Medical Technologies, Inc. | Steerable catheter device |
US6669655B1 (en) | 1999-10-20 | 2003-12-30 | Transurgical, Inc. | Sonic element and catheter incorporating same |
WO2001035846A1 (en) | 1999-11-16 | 2001-05-25 | Ganz Robert A | System and method of treating abnormal tissue in the human esophagus |
US20010030107A1 (en) | 2000-01-03 | 2001-10-18 | Peter Simpson | Auger lock |
US7137395B2 (en) | 2000-02-29 | 2006-11-21 | The Johns Hopkins University | Circumferential pulmonary vein ablation using a laser and fiberoptic balloon catheter |
WO2001072373A2 (en) | 2000-03-24 | 2001-10-04 | Transurgical, Inc. | Apparatus and method for intrabody thermal treatment |
US7497844B2 (en) | 2000-03-31 | 2009-03-03 | Medtronic, Inc. | System and method for positioning implantable medical devices within coronary veins |
US6582536B2 (en) | 2000-04-24 | 2003-06-24 | Biotran Corporation Inc. | Process for producing steerable sheath catheters |
US20020107514A1 (en) | 2000-04-27 | 2002-08-08 | Hooven Michael D. | Transmural ablation device with parallel jaws |
US6546935B2 (en) | 2000-04-27 | 2003-04-15 | Atricure, Inc. | Method for transmural ablation |
EP1642544B1 (en) | 2000-05-03 | 2009-04-08 | C.R.Bard, Inc. | Apparatus for mapping and ablation in electrophysiology procedures |
US6579278B1 (en) | 2000-05-05 | 2003-06-17 | Scimed Life Systems, Inc. | Bi-directional steerable catheter with asymmetric fulcrum |
US6375654B1 (en) | 2000-05-19 | 2002-04-23 | Cardiofocus, Inc. | Catheter system with working portion radially expandable upon rotation |
ATE290827T1 (en) | 2000-06-13 | 2005-04-15 | Atrionix Inc | SURGICAL ABLATION PROBE FOR FORMING AN ANNUAL LESION |
US6635054B2 (en) | 2000-07-13 | 2003-10-21 | Transurgical, Inc. | Thermal treatment methods and apparatus with focused energy application |
US6796972B1 (en) | 2000-07-14 | 2004-09-28 | Edwards Lifesciences Llc | Catheter anchoring balloon structure with irrigation |
JP2002078809A (en) | 2000-09-07 | 2002-03-19 | Shutaro Satake | Balloon catheter for electrically isolating pulmonary vein |
US6605055B1 (en) | 2000-09-13 | 2003-08-12 | Cardiofocus, Inc. | Balloon catheter with irrigation sheath |
US6916306B1 (en) | 2000-11-10 | 2005-07-12 | Boston Scientific Scimed, Inc. | Steerable loop structures for supporting diagnostic and therapeutic elements in contact with body tissue |
US6522933B2 (en) | 2001-03-30 | 2003-02-18 | Biosense, Webster, Inc. | Steerable catheter with a control handle having a pulley mechanism |
US20020183739A1 (en) | 2001-03-30 | 2002-12-05 | Long Gary L. | Endoscopic ablation system with sealed sheath |
DE10116056B4 (en) | 2001-03-30 | 2005-09-08 | Karl Storz Gmbh & Co. Kg | Endoscopic visualization device with different image systems |
AU2002258990A1 (en) | 2001-04-23 | 2002-11-05 | Transurgical, Inc. | Improvements in ablation therapy |
US6648875B2 (en) | 2001-05-04 | 2003-11-18 | Cardiac Pacemakers, Inc. | Means for maintaining tension on a steering tendon in a steerable catheter |
US6771996B2 (en) | 2001-05-24 | 2004-08-03 | Cardiac Pacemakers, Inc. | Ablation and high-resolution mapping catheter system for pulmonary vein foci elimination |
US6706004B2 (en) | 2001-05-31 | 2004-03-16 | Infraredx, Inc. | Balloon catheter |
US6814730B2 (en) | 2001-10-09 | 2004-11-09 | Hong Li | Balloon catheters for non-continuous lesions |
US6907298B2 (en) | 2002-01-09 | 2005-06-14 | Medtronic, Inc. | Method and apparatus for imparting curves in implantable elongated medical instruments |
JP2003210028A (en) | 2002-01-23 | 2003-07-29 | Iseki & Co Ltd | Conveying screw of zoom auger |
US7717899B2 (en) | 2002-01-28 | 2010-05-18 | Cardiac Pacemakers, Inc. | Inner and outer telescoping catheter delivery system |
US6932809B2 (en) | 2002-05-14 | 2005-08-23 | Cardiofocus, Inc. | Safety shut-off device for laser surgical instruments employing blackbody emitters |
JP2004065076A (en) | 2002-08-05 | 2004-03-04 | Iseki & Co Ltd | Conveying screw of zoom auger |
US6997924B2 (en) | 2002-09-17 | 2006-02-14 | Biosense Inc. | Laser pulmonary vein isolation |
US6908484B2 (en) * | 2003-03-06 | 2005-06-21 | Spinecore, Inc. | Cervical disc replacement |
WO2004110258A2 (en) | 2003-06-10 | 2004-12-23 | Cardiofocus, Inc. | Guided cardiac ablation catheters |
JP2008501444A (en) | 2004-06-07 | 2008-01-24 | エドワーズ ライフサイエンシーズ コーポレイション | Method and device for directional resection of tissue |
US20080039746A1 (en) | 2006-05-25 | 2008-02-14 | Medtronic, Inc. | Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
US20080108870A1 (en) | 2006-11-06 | 2008-05-08 | Wiita Bruce E | Apparatus and method for stabilizing an image from an endoscopic camera |
KR101666859B1 (en) * | 2009-10-01 | 2016-10-17 | 마코 서지컬 코포레이션 | Tool, kit-of-parts for multi-functional tool, and robotic system for same |
WO2011041635A2 (en) | 2009-10-02 | 2011-04-07 | Cardiofocus, Inc. | Cardiac ablation system with inflatable member having multiple inflation settings |
WO2011041638A2 (en) | 2009-10-02 | 2011-04-07 | Cardiofocus, Inc. | Cardiac ablation system with automatic safety shut-off feature |
US8696653B2 (en) | 2009-10-02 | 2014-04-15 | Cardiofocus, Inc. | Cardiac ablation system with pulsed aiming light |
WO2011044248A2 (en) | 2009-10-06 | 2011-04-14 | Cardiofocus, Inc. | Cardiac ablation image analysis system and process |
-
2004
- 2004-06-10 US US10/865,558 patent/US8540704B2/en not_active Expired - Lifetime
-
2013
- 2013-07-26 US US13/952,013 patent/US20140031802A1/en not_active Abandoned
-
2016
- 2016-12-15 US US15/380,637 patent/US9861437B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5152759A (en) * | 1989-06-07 | 1992-10-06 | University Of Miami, School Of Medicine, Dept. Of Ophthalmology | Noncontact laser microsurgical apparatus |
US5409483A (en) * | 1993-01-22 | 1995-04-25 | Jeffrey H. Reese | Direct visualization surgical probe |
Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10716462B2 (en) | 2011-09-22 | 2020-07-21 | The George Washington University | Systems and methods for visualizing ablated tissue |
US11559192B2 (en) | 2011-09-22 | 2023-01-24 | The George Washington University | Systems and methods for visualizing ablated tissue |
US10736512B2 (en) | 2011-09-22 | 2020-08-11 | The George Washington University | Systems and methods for visualizing ablated tissue |
US10076238B2 (en) | 2011-09-22 | 2018-09-18 | The George Washington University | Systems and methods for visualizing ablated tissue |
US11096584B2 (en) | 2013-11-14 | 2021-08-24 | The George Washington University | Systems and methods for determining lesion depth using fluorescence imaging |
US11457817B2 (en) | 2013-11-20 | 2022-10-04 | The George Washington University | Systems and methods for hyperspectral analysis of cardiac tissue |
US11559352B2 (en) | 2014-11-03 | 2023-01-24 | The George Washington University | Systems and methods for lesion assessment |
US10722301B2 (en) | 2014-11-03 | 2020-07-28 | The George Washington University | Systems and methods for lesion assessment |
US10143517B2 (en) | 2014-11-03 | 2018-12-04 | LuxCath, LLC | Systems and methods for assessment of contact quality |
US11596472B2 (en) | 2014-11-03 | 2023-03-07 | 460Medical, Inc. | Systems and methods for assessment of contact quality |
US10682179B2 (en) | 2014-11-03 | 2020-06-16 | 460Medical, Inc. | Systems and methods for determining tissue type |
KR102513664B1 (en) * | 2014-11-25 | 2023-03-23 | 460메디컬, 인크. | Visualization catheters |
AU2015353464B2 (en) * | 2014-11-25 | 2020-07-16 | 460Medical, Inc. | Visualization catheters |
US20160143522A1 (en) * | 2014-11-25 | 2016-05-26 | LuxCath, LLC | Visualization Catheters |
JP2017536891A (en) * | 2014-11-25 | 2017-12-14 | ラックスキャス・リミテッド・ライアビリティ・カンパニーLuxcath, Llc | Visualization catheter |
KR20170134316A (en) * | 2014-11-25 | 2017-12-06 | 럭스캐스, 엘엘씨 | Visualization catheters |
CN107106221A (en) * | 2014-11-25 | 2017-08-29 | 拉克斯凯瑟有限责任公司 | visualization catheter |
US10089849B2 (en) * | 2015-03-12 | 2018-10-02 | Honeywell International Inc. | Wireless mesh network gas detection real time location system |
US20180075728A1 (en) * | 2015-03-12 | 2018-03-15 | James Liu | Wireless mesh network gas detection real time location system |
US10725004B2 (en) | 2015-05-13 | 2020-07-28 | Honeywell International Inc. | Method to auto-configure gas detectors based on real-time location |
US10156552B2 (en) | 2015-05-13 | 2018-12-18 | Honeywell International Inc. | Method to auto-configure gas detectors based on real-time location |
US10779904B2 (en) | 2015-07-19 | 2020-09-22 | 460Medical, Inc. | Systems and methods for lesion formation and assessment |
US11154186B2 (en) | 2015-07-31 | 2021-10-26 | University Of Utah Research Foundation | Devices, systems, and methods for imaging and treating a selected tissue |
US11344365B2 (en) | 2016-01-05 | 2022-05-31 | Cardiofocus, Inc. | Ablation system with automated sweeping ablation energy element |
US11832878B2 (en) | 2016-01-05 | 2023-12-05 | Cardiofocus, Inc. | Ablation system with automated ablation energy element |
US11146723B2 (en) | 2016-12-16 | 2021-10-12 | Sony Corporation | Optical scope system for capturing an image of a scene |
US11729522B2 (en) | 2016-12-16 | 2023-08-15 | Sony Group Corporation | Optical scope system for capturing an image of a scene |
US11602270B2 (en) | 2017-02-01 | 2023-03-14 | University Of Utah Research Foundation | Devices and methods for mapping cardiac tissue |
USD851245S1 (en) | 2017-04-14 | 2019-06-11 | Cardiofocus, Inc. | Compliant balloon |
US11389236B2 (en) | 2018-01-15 | 2022-07-19 | Cardiofocus, Inc. | Ablation system with automated ablation energy element |
Also Published As
Publication number | Publication date |
---|---|
US8540704B2 (en) | 2013-09-24 |
US20050065504A1 (en) | 2005-03-24 |
US9861437B2 (en) | 2018-01-09 |
US20170156793A1 (en) | 2017-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9861437B2 (en) | Guided cardiac ablation catheters | |
US9033961B2 (en) | Cardiac ablation catheters for forming overlapping lesions | |
US8696653B2 (en) | Cardiac ablation system with pulsed aiming light | |
WO2004110258A2 (en) | Guided cardiac ablation catheters | |
US8025661B2 (en) | Coaxial catheter instruments for ablation with radiant energy | |
US20130289358A1 (en) | Cardiac ablation system with automatic safety shut-off feature | |
US20110082450A1 (en) | Cardiac ablation system with inflatable member having multiple inflation settings | |
US7935108B2 (en) | Deflectable sheath catheters | |
US6626900B1 (en) | Intralumenal contact sensor | |
US20050234437A1 (en) | Deflectable sheath catheters with out-of-plane bent tip | |
US20050222558A1 (en) | Methods of cardiac ablation employing a deflectable sheath catheter | |
US20050234436A1 (en) | Methods of cardiac ablation in the vicinity of the right inferior pulmonary vein |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: OXFORD FINANCE LLC, VIRGINIA Free format text: SECURITY INTEREST;ASSIGNOR:CARDIOFOCUS, INC.;REEL/FRAME:033434/0399 Effective date: 20140730 Owner name: SILICON VALLEY BANK, MASSACHUSETTS Free format text: SECURITY INTEREST;ASSIGNOR:CARDIOFOCUS, INC.;REEL/FRAME:033434/0399 Effective date: 20140730 |
|
AS | Assignment |
Owner name: OXFORD FINANCE LLC, VIRGINIA Free format text: SECURITY AGREEMENT;ASSIGNOR:CARDIOFOCUS, INC.;REEL/FRAME:035497/0393 Effective date: 20150424 Owner name: SILICON VALLEY BANK, MASSACHUSETTS Free format text: SECURITY AGREEMENT;ASSIGNOR:CARDIOFOCUS, INC.;REEL/FRAME:035497/0393 Effective date: 20150424 |
|
AS | Assignment |
Owner name: CARDIOFOCUS, INC., MASSACHUSETTS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MELSKY, GERALD;ARNOLD, JEFFREY M.;SINOFSKY, EDWARD L.;AND OTHERS;SIGNING DATES FROM 20090701 TO 20090904;REEL/FRAME:040637/0163 |
|
AS | Assignment |
Owner name: SOLAR CAPITAL LTD., NEW YORK Free format text: SECURITY INTEREST;ASSIGNOR:CARDIOFOCUS, INC.;REEL/FRAME:041805/0976 Effective date: 20170331 Owner name: SILICON VALLEY BANK, MASSACHUSETTS Free format text: SECURITY INTEREST;ASSIGNOR:CARDIOFOCUS, INC.;REEL/FRAME:041805/0976 Effective date: 20170331 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |