US20130199668A1 - Device for transferring and dosing biomedical fluids between hospital containers - Google Patents

Device for transferring and dosing biomedical fluids between hospital containers Download PDF

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Publication number
US20130199668A1
US20130199668A1 US13/877,265 US201113877265A US2013199668A1 US 20130199668 A1 US20130199668 A1 US 20130199668A1 US 201113877265 A US201113877265 A US 201113877265A US 2013199668 A1 US2013199668 A1 US 2013199668A1
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US
United States
Prior art keywords
extremity
handle
syringe body
motorised
piston
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/877,265
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English (en)
Inventor
Guiseppe MAFFEI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of US20130199668A1 publication Critical patent/US20130199668A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/22—Arrangements for transferring or mixing fluids, e.g. from vial to syringe with means for metering the amount of fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient

Definitions

  • the present invention relates to a device for transferring and dosing biomedical fluids between hospital containers.
  • the patients are connected to a parenteral infusion line placed in communication with a series of bags containing the drugs to be administered.
  • Each bag is connected to the infusion line independently from the others by means of a series of valves and the dispensing of the drugs to the patient is done in succession, placing between the administration of one drug and the next an intermediate stage of cleaning of the infusion line by means of a lavage of a saline solution, so as to avoid any type of contamination between drugs.
  • these types of therapeutic treatments consist in the following sequence of operations: administering of the first drug, cleaning of the infusion line, administering of the second drug, new cleaning of the infusion line, administering of the third drug, and so on.
  • the drugs continue to be administered until the relevant bags containing the necessary doses prescribed by the doctor for the correct therapeutic treatment are completely empty.
  • the hospital technician usually has at disposal a series of bottles containing the drugs, from which he/she takes the required quantities and transfers these into the bags by means of a plurality of syringes (one for each drug, to avoid, in this case as well, any possible contamination between the fluids).
  • each syringe is made up of a syringe body made of transparent material, on which is shown a graduated measuring scale and inside which is fitted, sealed, a sliding piston, which is manually operated by the operator by means of a thrust rod.
  • the main aim of this invention is to provide a device for transferring and dosing biomedical fluids between hospital containers which is portable and versatile, allows dosing biomedical fluids in a practical, easy, functional and precise way, allows reducing the efforts on the part of the operator and the consequent accidents/lesions, and allows reducing the risk of human error without changing the normal use procedure and/or the work schedules.
  • Another object of this invention is to provide a device for transferring and dosing biomedical fluids between hospital containers that allows overcoming the mentioned drawbacks of the state of the art in the ambit of a simple, rational, easy and effective to use as well as low cost solution.
  • the present device for transferring and dosing biomedical fluids between hospital containers, comprising at least a syringe body for the containment of a biomedical fluid and at least a piston sealed fitted in a sliding way in said syringe body, said syringe body comprising a first extremity, having joining means to at least a first container from which taking the biomedical fluid and to at least a second container in which dispensing said biomedical fluid, and a second extremity opposite said first extremity, characterised by the fact that it comprises:
  • FIG. 1 is a front, schematic and partial view that illustrates an infusion line using the devices according to the invention to transfer and dose biomedical fluids;
  • FIG. 2 is an exploded, schematic and partial view of a device according to the invention.
  • FIG. 3 is a side view of the device of FIG. 2 .
  • a device for transferring and dosing biomedical fluids between hospital containers is globally indicated by 1 .
  • biomedical fluid means any liquid used in the medical/hospital field and intended to be administered to a patient by means of bags or other containers and which requires being precisely pre-dosed.
  • the biomedical fluids consist of a series of drugs F 1 , F 2 , F 3 , F 4 , e.g., for oncology therapy use, contained in an equal number of first containers R 1 , R 2 , R 3 , R 4 such as bottles or the like.
  • the use is contemplated of a plurality of devices 1 , one for each drug F 1 , F 2 , F 3 , F 4 .
  • Each device 1 comprises a syringe body 2 for containing the biomedical fluid F 1 , F 2 , F 3 , F 4 and a piston 3 seal fitted sliding in the syringe body 2 .
  • the syringe body 2 is composed of, e.g., a cylinder-shaped tubular element made of transparent, coloured or matt plastic material (polyurethane, polycarbonate, polyethylene, etc.).
  • the dimensions of the syringe body 2 can usefully vary according to the required containing capacity (e.g.: 10 ml, 20 ml, 30 ml, 50 ml, 60 ml).
  • the syringe body 2 has a first extremity 2 a, having joining means 4 for joining to the first containers R 1 , R 2 , R 3 , R 4 and to the second containers P 1 , P 2 , P 3 , P 4 , and a second extremity 2 b opposite the first extremity 2 a.
  • the first extremity 2 a terminates with an extremity cap 5 supporting the joining means 4 , which, preferably, are of the Luer and Luer-Lock type.
  • the second extremity 2 b is shaped to define a cross separation wall 6 , having a central hole 7 .
  • Each device 1 also comprises a handle 9 for the manual grip by a user and has a coupling seat 10 for fastening to the second extremity 2 b of the syringe body 2 .
  • the handle 9 has an ergonomic shape, with at least a portion in anti-slip material 11 to increase the fastness and the grip of the user's hand.
  • motorised means 12 to drive a thrust rod 13 suitable for pushing the piston 3 .
  • the motorised means 12 are made up of a linear actuator connected to the thrust rod 13 and suitable for achieving the straight to-and-from movement of the thrust rod 13 .
  • the motorised means 12 are associated with a power supply battery 14 mounted in the handle 9 ; the power supply battery 14 is preferably of the rechargeable type and is associated with two terminals 15 for connecting to a recharging station, but alternatively, it cannot be ruled out that this is made up of one or more disposable type batteries.
  • the cartridge 8 is intended to be fitted on the handle 9 with the cross separation wall 6 facing the coupling seat 10 , in correspondence to which the thrust rod 13 protrudes from the handle 9 and is intended to cross the transit hole 7 to operate the piston 3 .
  • first temporary fastening means 16 , 17 for the slot-in fitting of the cartridge 8 on the handle 9 .
  • second temporary fastening means 18 , 19 are placed between the piston 3 and the thrust rod 13 to allow the connection and dragging of the piston 3 by the thrust rod 13 .
  • the first temporary fastening means 16 , 17 and the second temporary fastening means 18 , 19 are of the bayonet type, but it cannot be ruled out that alternatively they be slotted in or consist of a connection by friction or the like.
  • control means 20 , 21 associated with the motorised means 12 and suitable for controlling their operation to obtain the volumetric dosage, including the micro-volumetric type dosage, both of the quantity of biomedical fluid F 1 , F 2 , F 3 , F 4 to be taken from the first containers R 1 , R 2 , R 3 , R 4 , and of the quantity of biomedical fluid F 1 , F 2 , F 3 , F 4 to be dispensed into the second containers P 1 , P 2 , P 3 , P 4 .
  • the control means 20 , 21 comprise a processing and control unit 20 and a control interface 21 , of the type of a keypad or the like, for controlling the motorised means 12 and designed to start/stop/set the processing and control unit 20 according to the user's requirements.
  • the processing and control unit 20 can usefully be of the programmable type to set the quantities of biomedical fluid F 1 , F 2 , F 3 , F 4 to be taken and/or dispensed.
  • the processing and control unit 20 is able to operate the thrust rod 13 independently for a section of stroke corresponding to the quantity of biomedical fluid F 1 , F 2 , F 3 , F 4 to be taken and/or to be dispensed.
  • the syringe body 2 can show a graduated scale 22 , the stop of the piston 3 during the taking/dispensing stage of the biomedical fluid F 1 , F 2 , F 3 , F 4 being entrusted to the care and skill of the user.
  • the handle 9 also has display means 23 , of the type of an electronic display or the like, suitable for showing the operating parameters of the processing and control unit 20 and, more in general, all types of information useful for the user.
  • identification means 24 for identifying at least one between the syringe body 2 and the piston 3 .
  • the identification means 24 are electronically associated with the processing and control unit 20 and suitable for preventing the operation of the motorised means 12 in case of the syringe body 2 and/or the piston 3 not being identified.
  • the identification means 24 are of the type of a reader chosen from the list comprising: bar code readers, optical readers, electromagnetic readers.
  • the identification means 24 are made up of a bar code reader designed to recognise a bar code 25 shown on the cross separation wall 6 .
  • the identification means 24 are of different type and, e.g., consist of an RFID magnetic recognition system.
  • the handle 9 comprises means for recognising the correct coupling of the first temporary fastening means 16 , 17 and of the second temporary fastening means 18 , 19 .
  • Such recognition means are associated with the processing and control unit 20 and suitable for preventing the operation of the motorised means 12 in case of incorrect coupling of the first temporary fastening means 16 , 17 and of the second temporary fastening means 18 , 19 .
  • the recognition means made in this way allow the device 1 to operate in conditions of utmost safety only in the case of both the syringe body 2 and the piston 3 being stably coupled, with slot-in coupling, to the coupling seat 10 and to the thrust rod 13 respectively, so as to prevent their accidental disassembly during use.
  • the present invention operates as follows.
  • Each handle 9 is prepared to be conveniently used with an indefinite number of cartridges 8 inasmuch, at the end of their normal life cycle, these can be separated from the handle 9 , rejected and replaced by new ones.
  • the processing and control unit 20 automatically commands the forward movement of the thrust rod 13 until this is coupled with the piston 3 .
  • the processing and control unit 20 proceeds to identify the cartridge 8 by means of the identification means 24 and performs recognition of the correct coupling of the first temporary fastening means 16 , 17 and of the second temporary fastening means 18 , 19 and, in the case of positive outcome, allows the subsequent operation of the motorised means 12 .
  • the joining means 4 to the second corresponding container P 1 , P 2 , P 3 , P 4 , the biomedical fluid F 1 , F 2 , F 3 , F 4 can be dispensed and the device 1 is ready for the subsequent operations.
  • the cartridge 8 becomes worn and contaminated and has to be replaced with a new one in the same way as previously described and shown.
  • the use is contemplated of a plurality of devices 1 , or at least a plurality of handles 9 , one for each drug F 1 , F 2 , F 3 , F 4 , but nothing prevents having just one handle 9 and a plurality of cartridges 8 to be used alternately with the handle 9 to transfer the drugs F 1 , F 2 , F 3 , F 4 , being careful to use each cartridge 8 with one and only one drug F 1 , F 2 , F 3 , F 4 .

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Mechanical Engineering (AREA)
US13/877,265 2010-11-09 2011-11-07 Device for transferring and dosing biomedical fluids between hospital containers Abandoned US20130199668A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMO2010A000319A IT1403334B1 (it) 2010-11-09 2010-11-09 Dispositivo per il trasferimento ed il dosaggio di fluidi biomedicali tra recipienti ospedalieri
ITMO2010A000319 2010-11-09
PCT/IB2011/002622 WO2012063111A1 (en) 2010-11-09 2011-11-07 Device for transferring and dosing biomedical fluids between hospital containers

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/002622 A-371-Of-International WO2012063111A1 (en) 2010-11-09 2011-11-07 Device for transferring and dosing biomedical fluids between hospital containers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/987,927 Continuation US9474858B2 (en) 2010-11-09 2016-01-05 Dosing method with a device for transferring and dosing biomedical fluids between hospital containers

Publications (1)

Publication Number Publication Date
US20130199668A1 true US20130199668A1 (en) 2013-08-08

Family

ID=43742851

Family Applications (2)

Application Number Title Priority Date Filing Date
US13/877,265 Abandoned US20130199668A1 (en) 2010-11-09 2011-11-07 Device for transferring and dosing biomedical fluids between hospital containers
US14/987,927 Active US9474858B2 (en) 2010-11-09 2016-01-05 Dosing method with a device for transferring and dosing biomedical fluids between hospital containers

Family Applications After (1)

Application Number Title Priority Date Filing Date
US14/987,927 Active US9474858B2 (en) 2010-11-09 2016-01-05 Dosing method with a device for transferring and dosing biomedical fluids between hospital containers

Country Status (8)

Country Link
US (2) US20130199668A1 (it)
EP (1) EP2637627B1 (it)
JP (1) JP2013542802A (it)
CN (1) CN103200923B (it)
CA (1) CA2817354A1 (it)
ES (1) ES2540177T3 (it)
IT (1) IT1403334B1 (it)
WO (1) WO2012063111A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMO20120219A1 (it) * 2012-09-17 2014-03-18 Giuseppe Maffei Apparecchiatura per il trasferimento di fluidi biomedicali tra recipienti ospedalieri
FR3001126B1 (fr) * 2013-01-24 2016-02-12 Jce Biotechnology Appareil a main d'aide au remplissage d'une poche ou similaire, telle qu'un infuseur
WO2021150677A1 (en) * 2020-01-22 2021-07-29 Becton, Dickinson And Company System and device for drug preparation

Citations (4)

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US5269762A (en) * 1992-04-21 1993-12-14 Sterling Winthrop, Inc. Portable hand-held power assister device
US6056165A (en) * 1998-10-21 2000-05-02 Speranza; James D. Free standing cordless gun for dispensing liquid glue and similar materials
US6929619B2 (en) * 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
US7887513B2 (en) * 2004-11-11 2011-02-15 Nemoto Kyorindo Co., Ltd Chemical liquid injection system

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DE3522645A1 (de) * 1985-06-25 1987-01-08 Hausmann Ag Labor Verfahren und vorrichtung zum sterilen vermischen von parenteral zu verabreichenden fluessigkeiten
JPS6452481A (en) * 1987-08-25 1989-02-28 Fujiya Tsuji Drug liquid quantitative filling apparatus for syringe
US5336201A (en) * 1992-06-29 1994-08-09 Baxter International Inc. Syringe driving apparatus
US5672155A (en) * 1996-06-14 1997-09-30 Riley; Robert Q. Fluid transfer apparatus
US5911252A (en) * 1997-04-29 1999-06-15 Cassel; Douglas Automated syringe filling system for radiographic contrast agents and other injectable substances
EP1033143B1 (en) * 1999-02-26 2007-01-10 F. Hoffmann-La Roche Ag Device for administering a medication
IT1316902B1 (it) * 2000-06-09 2003-05-13 Sidam Di Azzolini Graziano E C Dispositivo medicale preassemblato monouso per la somministrazione apazienti di almeno due medicamenti in proporzioni prestabilite.
ATE350276T1 (de) * 2001-02-28 2007-01-15 Grifols Sa Vorrichtung zum füllen von behältern für pharmazeutische zwecke und dergleichen
DK2061536T3 (da) * 2006-08-23 2012-02-06 Medtronic Minimed Inc Anlæg og fremgangsmåde til fyldning af beholdere og til udlevering af et infusionsmedium
WO2008113772A1 (en) * 2007-03-21 2008-09-25 Novo Nordisk A/S A medical delivery system having container recognition and container for use with the medical delivery system
NZ556142A (en) * 2007-06-25 2009-11-27 Novartis Ag Animal remedy dispensing means
JP5428465B2 (ja) * 2009-03-31 2014-02-26 パナソニック株式会社 シリンジ駆動装置
EP2238999A1 (fr) * 2009-04-02 2010-10-13 Vincent Pongpairochana Dispositif d'injection automatique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5269762A (en) * 1992-04-21 1993-12-14 Sterling Winthrop, Inc. Portable hand-held power assister device
US6056165A (en) * 1998-10-21 2000-05-02 Speranza; James D. Free standing cordless gun for dispensing liquid glue and similar materials
US6929619B2 (en) * 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
US7887513B2 (en) * 2004-11-11 2011-02-15 Nemoto Kyorindo Co., Ltd Chemical liquid injection system

Also Published As

Publication number Publication date
US9474858B2 (en) 2016-10-25
EP2637627B1 (en) 2015-03-25
ES2540177T3 (es) 2015-07-09
ITMO20100319A1 (it) 2012-05-10
CA2817354A1 (en) 2012-05-18
JP2013542802A (ja) 2013-11-28
WO2012063111A1 (en) 2012-05-18
US20160129184A1 (en) 2016-05-12
CN103200923B (zh) 2016-04-06
IT1403334B1 (it) 2013-10-17
CN103200923A (zh) 2013-07-10
EP2637627A1 (en) 2013-09-18

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