Classifications

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  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0216—Solid or semisolid forms
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  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/22—Peroxides; Oxygen; Ozone
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  • A61K8/24—Phosphorous; Compounds thereof
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  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
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  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
• • A—HUMAN NECESSITIES
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  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/362—Polycarboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/42—Amides
• • A—HUMAN NECESSITIES
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  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
  • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
• • A—HUMAN NECESSITIES
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  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
  • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
• • A—HUMAN NECESSITIES
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  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
  • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
  • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• • A—HUMAN NECESSITIES
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  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
  • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
  • A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
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  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/86—Polyethers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/90—Block copolymers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/30—Characterized by the absence of a particular group of ingredients
  • A61K2800/31—Anhydrous
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  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
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  • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
  • A61K2800/87—Application Devices; Containers; Packaging

Definitions

• compositions described in the art for preventing or treating the discoloration of teeth there are a variety of compositions described in the art for preventing or treating the discoloration of teeth.
• products containing bleaching materials are commercially available for professional and consumer use.
• the materials most commonly used in teeth whitening today are peroxides.
• Peroxides are generally deemed safe from a physiological standpoint, and can be effective to whiten teeth.
• Such peroxides include hydrogen peroxide, carbamide peroxide, sodium perborate, and sodium percarbonate. When these peroxides are in appropriate contact with teeth they will usually oxidize stains, rendering teeth whiter.
• Current home treatment methods include abrasive toothpastes, toothpastes that produce oxides, whitening gels for use with a dental tray and whitening strips.
• the effectiveness of such techniques depends on a variety of factors including the type and intensity of the stain, bleaching agent contact time on the teeth, the amount of available bleaching active in the composition, and consumer compliance. Effectiveness is also dependent on the amount of bleaching active in the composition, the ability of the active to be released during use, and the stability of the active in the product. However, the effectiveness of many of these treatments is adversely affected because of deficiencies in one or more factors relating to the composition and consumer compliance.
• Some embodiments of the present invention provide oral care compositions having improved flavor and flavor release characteristics. Some embodiments comprise a whitening agent, an anionic surfactant in an amount from 1.75 to 2% w/w, and an orally acceptable carrier having a low water content.
• the whitening oral care composition is a single phase composition having improved flavor, comprising a peroxide whitening agent, an anionic surfactant, and a substantially anhydrous orally acceptable carrier.
• the anionic surfactant comprises sodium lauryl sulfate.
• the anionic surfactant is present in an amount from 1.75% to 2% w/w.
• the anionic surfactant is present in an amount from 1.8% to 2.0% w/w.
• the anionic surfactant is present in an amount from 1.8% to 2.0% w/w.
• the anionic surfactant is present in an amount from 1.8% to 2.0% w/w.
• the anionic surfactant is present in an amount from 1.9% to 2.0% w/w.
• Still further embodiments provide oral care compositions in which the anionic surfactant is present in the amount of 2.0% w/w.
• the whitening agent is selected from the group consisting of: hydrogen peroxide; a bound peroxide; and a solid.
• the bound peroxide comprises hydrogen peroxide and a polymer.
• the bound peroxide comprises any peroxide compound and a porous cross-linked polymer, such as polymers of polyvinylpyrrolidone, polyacrylates, a polymethacrylates, and a polyitaconates.
• the solid peroxide is sodium perborate or urea peroxide.
• aspects of the invention provide methods of whitening teeth by contacting one or more tooth surface(s) with the whitening dentifrice compositions described herein.
• compositions and methods described herein afford benefits over compositions and methods known in the art. Such benefits include, inter alia, enhanced flavor release characteristics resulting in improved flavor availability and improved taste. Further benefits and embodiments will be readily apparent to persons having ordinary skill in the art from a review of the detailed description set forth herein.
• low water content means the total concentration of water, including any free water and all water contained in any ingredients, is less than 4%.
• whitening agent refers to a material that is effective in whitening a tooth surface to which it is applied.
• peroxide compound refers to an oxidizing compound comprising a bivalent oxygen-oxygen group.
• the present invention provides oral care compositions and methods for administration, or application to, a human or other animal subject.
• an “oral care composition” is any composition that is suitable for administration or application to the oral cavity of a human or animal subject for enhancing the health, hygiene or appearance of the subject.
• an oral care composition is retained in the oral cavity for a time sufficient to affect the intended utility.
• the present invention provides single phase whitening oral care compositions, comprising a whitening agent, sodium lauryl sulfate in an amount from 1.75% to 2% w/w, and an orally acceptable carrier having a low water content.
• the oral care compositions of this invention provide highly efficacious whitening and cleaning while at the same time having an enhanced flavor release profile as determined by organoleptic evaluations.
• the water content of the carrier be kept relatively low, and preferably substantially anhydrous. In some embodiments, the water content is less than 4% w/w. In other embodiments, the water content is less than 2% w/w, while in other embodiments, the water content is 0% w/w.
• the selection of the whitening agent in conjunction with a carrier possessing a low water content allows stabilized delivery of the whitening agent and provides improved flavor release and taste. Significantly, the demonstrated improvement in flavor release and taste has not adversely affected the whitening activity of the compositions described herein.
• the compositions comprise a whitening agent.
• the whitening agent comprises a peroxide compound.
• the whitening agent comprises a solid whitening agent or a bound whitening agent which is a substantially anhydrous oxygen generating compound.
• solid whitening agents include peroxide compounds, metal chlorites, and persulfate.
• Exemplary peroxide compounds include hydroperoxides, hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, pharmaceutically-acceptable salts thereof, and mixtures thereof.
• Peroxides of alkali and alkaline earth metals include lithium peroxide, potassium peroxide, sodium peroxide, sodium percarborate, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof.
• Organic peroxy compounds include urea peroxide, glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, and monoperoxyphthalate, and mixtures thereof.
• Peroxy acids and their salts include organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as and perborate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof.
• Preferred solid peroxides are sodium perborate, sodium percarborate, urea peroxide, and mixtures thereof.
• Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite.
• the whitening agent may be bound.
• peroxide may be bound to a polymer such as PVP (poly-N-vinylpyrrolidone).
• PVP poly-N-vinylpyrrolidone
• Suitable PVP complexes are disclosed, for example, in U.S. Pat. No. 5,122,370, the contents of which are incorporated herein by reference in their entirety.
• Linear PVP peroxide and cross-linked PVP peroxide sold as PeroxydoneTM from ISP Corp. are also peroxide compounds useful as whitening agents in the present invention.
• PVP peroxide can be effectively produced by mixing linear PVP or cross-linked PVP with concentrated liquid hydrogen peroxide in the dentifrice.
• the peroxide compound comprises hydrogen peroxide.
• the peroxide compound comprises from 0.1% to 50% w/w, preferably from 0.1% to 40% w/w, and more preferably from 0.1% to 30% w/w, of the oral care composition.
• the peroxide compound consists essentially of hydrogen peroxide.
• the hydrogen peroxide delivered by the compositions of the present invention is in an amount from 0.1% to 3% w/w, and is preferably delivered in an amount from 1% to 2% w/w.
• compositions of the present comprise an orally acceptable carrier.
• the carrier does not substantially reduce the efficacy of the active material. Selection of specific carrier components is dependant on the desired product form, including dentifrices, rinses, gels, and paints.
• the oral care composition is a dentifrice.
• the term “dentifrice” as used throughout this description denotes a paste, gel, toothpowder, dental tablet or liquid formulation.
• the dentifrice deep striped, surface striped, or multilayered, having a gel surrounding the paste.
• the composition is used with a tape, tray, mouthpiece or similar appliance.
• the carrier is a low water content orally acceptable carrier and may include any known ingredients or additives.
• the water content of a single phase oral care composition is less than 4%, 2%, 1% or 0.1% w/w.
• the orally acceptable carrier is substantially anhydrous.
• the substantially anhydrous carrier further comprises various ingredients to adjust the rheology and feel of the composition such as humectants, surface active agents, thickening or gelling agents, etc.
• Suitable low water content carriers include but are not limited to Pluraflo® L4370 and Pluracare® L1220, polytheylene glycol such PEG400, PEG600, PEG/PPG copolymers such as PEG/PPG 38/8 copolymer, PEG/PPG-116/66 copolymer sold as Pluracare L4370 and Pluracare L1220 from BASF, respectively.
• Propylene glycol or glycerin may be present in an amount from 0% to 15% w/w.
• compositions further comprise adhesion agents; viscosity modifiers; diluents; nonionic, cationic or amphoteric surfactants; foam modulators; peroxide activators; peroxide stabilizing agents; abrasives; pH modifying agents; humectants; mouth feel agents; sweeteners; flavoring agents; and colorants, or combinations of two or more thereof.
• adhesion agents such as adhesion agents; viscosity modifiers; diluents; nonionic, cationic or amphoteric surfactants; foam modulators; peroxide activators; peroxide stabilizing agents; abrasives; pH modifying agents; humectants; mouth feel agents; sweeteners; flavoring agents; and colorants, or combinations of two or more thereof.
• the surfactant may enhance stability of the formulation, help clean the oral cavity surfaces through detergency, and provide foam upon agitation, e.g., during brushing with a dentifrice composition of the invention.
• Suitable anionic surfactants include water-soluble salts of C 8-20 alkyl sulfates, sulfonated monoglycerides of C 8-20 fatty acids, sarcosinates, taurates and mixtures thereof.
• Suitable nonionic surfactants include poloxamers, polyoxyethylene sorbitan esters, fatty alcohol ethoxylates, alkylphenol ethoxylates, tertiary amine oxides, tertiary phosphine oxides, dialkyl sulfoxides and mixtures thereof.
• Suitable amphoteric surfactants include derivatives of C 8-20 aliphatic secondary and tertiary amines having an anionic group such as carboxylate, sulfate, sulfonate, phosphate or phosphonate.
• a suitable example is cocoamidopropyl betaine.
• one or more surfactants may be present in a total amount of from 1.75% to 2% w/w. In some embodiments, one or more surfactants may be present in a total amount of from 1.8% to 2% w/w. In some embodiments, one or more surfactants may be present in a total amount of from 1.9% to 2% w/w. In some embodiments, one or more surfactants may be present in the total amount of 2% w/w.
• the orally acceptable carrier further comprises dispersants such as polymers and/or copolymers of polyethylene glycol, of ethylene oxide, propylene oxide, and of silicone. If such copolymers/polymers are used, they may be selected from the commercially available materials Pluraflo® L4370 and Pluracare® L1220 (available from BASF, Wyandotte, Mich., United States of America).
• the viscosity of the dentrifice is between 10,000 CPS and 700,000 CPS. In some embodiments, the viscosity of the dentrifice is between 30,000 CPS and 300,000 CPS.
• one or more dispersants are present in a total amount of from 2% to 55% w/w and preferably from 2% to 35% w/w.
• Some embodiments of the present invention comprise a dental abrasive or combination of dental abrasive agents.
• abrasive or “abrasive agent” also includes materials commonly referred to as “polishing agents”.
• Suitable abrasives may include those previously considered to be incompatible in a peroxide containing formulation (“a peroxide-incompatible abrasive”).
• a peroxide-incompatible abrasive is one which, in an aqueous solution with hydrogen peroxide, substantially reacts with the hydrogen peroxide so as to reduce whitening efficacy of the solution.
• abrasive any orally acceptable abrasive can be used, but preferably, type, fineness (particle size) and amount of abrasive should be selected so that tooth enamel is not excessively abraded in normal use of the composition.
• Suitable abrasives include without limitation silica (in the form of silica gel, hydrated silica or precipitated silica), alumina, insoluble phosphates, calcium carbonate, resinous abrasives such as urea-formaldehyde condensation products and the like.
• insoluble phosphates useful as abrasives are orthophosphates, polymetaphosphates and pyrophosphates.
• Illustrative examples are dicalcium orthophosphate dihydrate, calcium pyrophosphate, ⁇ -calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate and insoluble sodium polymetaphosphate.
• Average particle size of an abrasive if present, is generally 0.1 to 30 ⁇ m, for example 1 to 20 ⁇ m or 5 to 15 ⁇ m.
• one or more abrasives is present in an amount of 0.1% to 40% w/w.
• the abrasive is calcium pyrophosphate.
• the calcium pyrophosphate is present in an amount from 5% to 50% w/w.
• the oral composition comprises an anticalculus agent.
• tartar control agents are categorized as being incompatible with some whitening agents, but some embodiments of the present invention incorporate tartar control agents and whitening agents in a single phase whitening composition.
• Suitable anticalculus agents include without limitation phosphates and polyphosphates (for example pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates.
• the anticalculus agent is present in an amount of 0.1% to 30% w/w.
• the oral care composition comprises a mixture of anticalculus agents.
• tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP) are used as the anticalculus agents.
• the anticalculus agent comprises 1% to 2% w/w TSPP, and 0% to 7% w/w STPP.
• the oral care composition optionally comprises a source of fluoride ions.
• the source of fluoride ions is selected from: fluoride; monofluorophosphate; and fluorosilicate salts.
• one or more fluoride ion-releasing compounds are optionally present in an amount providing a total of 100 to 20,000 ppm, 200 to 5,000 ppm, or 500 to 2,500 ppm, fluoride ions.
• the composition optionally comprises a thickening agent.
• a thickening agent can be used, including without limitation carbomers, also known as carboxyvinyl polymers, carrageenans, also known as Irish moss and more particularly -carrageenan (iota-carrageenan), high molecular weight polyethylene glycols (such as CARBOWAX®, available from The Dow Chemical Company), cellulosic polymers such as hydroxyethylcellulose, carboxymethylcellulose (CMC) and salts thereof, e.g., CMC sodium, natural gums such as karaya, xanthan, gum arabic and tragacanth, colloidal magnesium aluminum silicate, and colloidal and/or fumed silica and mixtures of the same.
• CMC carboxymethylcellulose
• the one or more optional thickening agents are present in a total amount of 0.1% to 90% w/w. In some embodiments, the one or more optional thickening agents are present in a total amount of 1% to 50% w/w. In some embodiments, the one or more optional thickening agents are present in a total amount of 5% to 35% w/w.
• Useful flavoring agents include any material or mixture of materials operable to enhance the taste of the composition. Any orally acceptable natural or synthetic flavoring agent can be used, such as flavoring oils, flavoring aldehydes, esters, alcohols, similar materials, and combinations thereof. Flavoring agents include vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, oil of wintergreen (methylsalicylate), peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, citrus oils, fruit oils and essences including those derived from lemon, orange, lime, grapefruit, apricot, banana, grape, apple, strawberry, cherry, pineapple, etc., bean- and nut-derived flavors such as coffee, cocoa, cola, peanut, almond, etc., adsorbed and encapsulated flavorants, and mixtures thereof.
• ingredients that provide fragrance and/or other sensory effect in the mouth, including cooling or warming effects.
• Such ingredients include menthol, menthyl acetate, menthyl lactate, camphor, eucalyptus oil, eucalyptol, anethole, eugenol, cassia, oxanone, ⁇ -irisone, propenyl guaiethol, thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-menthan-3-carboxamine, N,2,3-trimethyl-2-isopropylbutanamide, 3-1-menthoxypropane-1,2-diol, cinnamaldehyde glycerol acetal (CGA), methone glycerol acetal (MGA) and mixtures thereof.
• one or more flavoring agents are optionally present in a total amount of 0.01% to 5% w/w. In some embodiments, one or more flavoring agents are optionally present in a total amount of 0.05% to 2% w/w. In some embodiments, one or more flavoring agents are optionally present in a total amount of 0.1% to 2.5% w/w. In some embodiments, one or more flavoring agents are optionally present in a total amount from 0.1% to 0.5% w/w. In some embodiments, one or more flavoring agents are optionally present in the total amount of 2.25% w/w.
• Some embodiments optionally comprise a breath freshening agent.
• Any orally acceptable breath freshening agent can be used, including without limitation zinc salts such as zinc gluconate, zinc citrate and zinc chlorite, —ionone and mixtures thereof.
• One or more breath freshening agents are optionally present in a breath freshening effective total amount.
• Sweeteners among those useful herein include orally acceptable natural or artificial, nutritive or non-nutritive sweeteners.
• Such sweeteners include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and corn syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof, sucralose, dipeptide-based intense sweeteners, cyclamates, dihydrochalcones and mixtures thereof.
• Some embodiments optionally comprise one or more sweeteners.
• the one or more optional sweeteners are present in a total amount from 0.005% to 5% w/w. In some embodiments, the one or more optional sweeteners are present in a total amount from 0.01 to 1% w/w.
• Colorants among those useful herein include pigments, dyes, lakes and agents imparting a particular luster or reflectivity such as pearling agents.
• colorants are operable to provide a white or light-colored coating on a dental surface, to act as an indicator of locations on a dental surface that have been effectively contacted by the composition, and/or to modify appearance, in particular color and/or opacity, of the composition to enhance attractiveness to the consumer.
• any orally acceptable colorant can be used, including talc, mica, magnesium carbonate, calcium carbonate, magnesium silicate, magnesium aluminum silicate, silica, titanium dioxide, zinc oxide, red, yellow, brown and black iron oxides, ferric ammonium ferrocyanide, manganese violet, ultramarine, titaniated mica, bismuth oxychloride, FD&C dyes, and mixtures thereof.
• Some embodiments optionally comprise one or more colorants in a total amount from 0.001% to 20% w/w. In some embodiments, the one or more optional colorants are present in a total amount from 0.01% to 10% w/w. In some embodiments, the one or more optional colorants are present in a total amount from 0.1% to 5% w/w.
• Humectants useful herein include polyhydric alcohols such as glycerin, sorbitol, xylitol or low molecular weight PEGs.
• humectants are operable to prevent hardening of paste or gel compositions upon exposure to air.
• humectants also function as sweeteners.
• Some embodiments comprise one or more humectants in a total amount from 1% to 50% w/w. In some embodiments, the one or more humectants are present in a total among from 2% to 25% w/w. In some embodiments, the one or more humectants are present in a total among from 5% to 15% w/w.
• pH modifying agents among those useful herein include acidifying agents to lower pH, basifying agents to raise pH, and buffering agents to control pH within a desired range.
• acidifying agents to lower pH
• basifying agents to raise pH
• buffering agents to control pH within a desired range.
• one or more compounds selected from acidifying, basifying and buffering agents can be included to provide a pH of 2 to 10, or in various embodiments from 2 to 8, from 3 to 9, from 4 to 8, from 5 to 7, from 6 to 10, and from 7 to 9.
• Any orally acceptable pH modifying agent can be used, including without limitation carboxylic, phosphoric and sulfonic acids, acid salts (e.g., monosodium citrate, disodium citrate, monosodium malate, etc.), alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, phosphates (e.g., monosodium phosphate, trisodium phosphate, pyrophosphate salts, etc.), imidazole and mixtures thereof.
• One or more pH modifying agents are optionally present in a total amount effective to maintain the composition in an orally acceptable pH range.
• compositions optionally comprise one or more further active material(s), operable for the prevention or treatment of a condition or disorder of hard or soft tissue of the oral cavity; the prevention or treatment of a physiological disorder or condition; or to provide a cosmetic benefit.
• the compositions comprise stannous ion or a stannous ion source.
• Suitable stannous ion sources include without limitation stannous fluoride, other stannous halides such as stannous chloride dihydrate, stannous pyrophosphate, organic stannous carboxylate salts such as stannous foimate, acetate, gluconate, lactate, tartrate, oxalate, malonate and citrate, stannous ethylene glyoxide and the like.
• one or more stannous ion sources are optionally present in the total amount of 0.01% to 10% w/w.
• one or more stannous ion sources are optionally present in the total amount of 0.1% to 7% w/w. In other embodiments, one or more stannous ion sources are optionally present in the total amount of 1% to 5% w/w.
• compositions of the present invention further comprise an antimicrobial (e.g., antibacterial) agent.
• an antimicrobial agent e.g., antibacterial
• one or more antimicrobial agents are optionally present.
• one or more antimicrobial agents are optionally present in the amount of 0.05% to 10% w/w.
• one or more antimicrobial agents are optionally present in the amount of 0.1% to 3% w/w.
• Some embodiments of the present invention optionally comprise an antioxidant.
• Any orally acceptable antioxidant can be used, including butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and mixtures thereof.
• Some embodiments of the present invention optionally comprise a sialagogue or saliva-stimulating agent, an antiplaque agent, an anti-inflammatory agent, a desensitizing.
• a saliva stimulating agent can be used, including without limitation food acids such as citric, lactic, malic, succinic, ascorbic, adipic, fumaric, and tartaric acids, and mixtures thereof.
• compositions of the present invention can be prepared by conventional methods known to those skilled in the art.
• compositions of the present invention can be prepared by adding and mixing the ingredients of the composition in a suitable vessel such as a stainless steel tank provided with a mixer.
• the ingredients are added to the mixing vessel in the following order: diluent, thickening agent(s), peroxide composite (or other active) and any flavoring agent(s), colorant or sweetener.
• the flavoring agent is dissolved in Pluraflo® L4370 and Pluracare® L1220.
• the Pluraflo L4370 and Pluracare® L1220 are then added and the solution is mixed for five minutes.
• the peroxide or other whitening agent is added and the solution is mixed for 20 minutes until the mixture is homogenous. Additional ingredients such as coloring or sweeteners are added at any point during the mixing process but in various embodiments, such ingredients are preferably added last or close to last.
• Some embodiments of the present invention provide methods of whitening an oral surface in a human or animal subject.
• animal subject includes higher order non-human mammals such as canines, felines, and horses.
• the present invention provides a method of improving patient compliance with an oral care composition, comprising applying to an oral surface an effective amount of any one of the oral care compositions described herein.
• the oral care composition is applied and contacted with the oral surface.
• the dentifrice is applied regularly to an oral surface, preferably on a daily basis, at least one time daily for multiple days, but alternately every second or third day.
• the oral care composition is applied to an oral surface from 1 to 3 times daily, for at least 2 weeks.
• the oral care composition is applied to an oral surface from 1 to 3 times daily, up to 8 weeks.
• the oral care composition is applied to an oral surface from 1 to 3 times daily, for a period of four months to three years.
• the oral care composition is applied to the oral surfaces from 1 to 3 times daily, for a period in excess of 3 years.
• the oral care composition is applied and contacted with the oral surface.
• the dentifrice is applied regularly to an oral surface, preferably on a daily basis, at least one time daily for multiple days, but alternately every second or third day.
• the oral care composition is applied to an oral surface from 1 to 3 times daily, for at least 2 weeks.
• the oral care composition is applied to an oral surface from 1 to 3 times daily, up to 8 weeks.
• the oral care composition is applied to an oral surface from 1 to 3 times daily, for a period of four months to three years.
• the oral care composition is applied to the oral surfaces from 1 to 3 times daily, for a period in excess of 3 years.
• Table 1 below provides examples of oral dentifrice compositions containing an enhanced amount of sodium lauryl sulfate and a low water content.
• Table 2 reports organoleptic evaluation scores/ratings obtained from an experienced flavorist.
• the sodium lauryl sulfate (“SLS”) content was varied, while the flavoring agent content remained constant (2.25% w/w).
• the experienced flavorist rated these compositions on a scale of 0-6, with a rating of 6 being most preferred.
• SLS sodium lauryl sulfate

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