US20120095371A1 - Ultrasound transducer and cooling thereof - Google Patents

Ultrasound transducer and cooling thereof Download PDF

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Publication number
US20120095371A1
US20120095371A1 US13/049,022 US201113049022A US2012095371A1 US 20120095371 A1 US20120095371 A1 US 20120095371A1 US 201113049022 A US201113049022 A US 201113049022A US 2012095371 A1 US2012095371 A1 US 2012095371A1
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United States
Prior art keywords
transducer
ultrasonic
catheter
power beam
unfocused
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Abandoned
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US13/049,022
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English (en)
Inventor
Ariel Sverdlik
Or Shabtay
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Cardiosonic Ltd
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Cardiosonic Ltd
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Publication date
Application filed by Cardiosonic Ltd filed Critical Cardiosonic Ltd
Priority to US13/049,022 priority Critical patent/US20120095371A1/en
Assigned to CardioSonic Ltd. reassignment CardioSonic Ltd. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SHABTAY, OR, SVERDLIK, ARIEL
Priority to EP11782223.9A priority patent/EP2629848B1/fr
Priority to US13/880,083 priority patent/US20130204242A1/en
Priority to EP11785792.0A priority patent/EP2629849A1/fr
Priority to US13/879,400 priority patent/US9566456B2/en
Priority to PCT/IB2011/054639 priority patent/WO2012052925A1/fr
Priority to PCT/IB2011/054641 priority patent/WO2012052927A1/fr
Publication of US20120095371A1 publication Critical patent/US20120095371A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A61N7/022—Localised ultrasound hyperthermia intracavitary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00106—Sensing or detecting at the treatment site ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22081—Treatment of vulnerable plaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers

Definitions

  • the present invention relates to an ultrasound transducer device and cooling thereof and, more particularly, but not exclusively to the cooling of such a transducer device within a small vessel which may be filled with fluid, such as a blood vessel or other body lumen.
  • Sverdlik et al in PCT/IL2008/000234, filed Feb. 21, 2008 disclose a method of using ultrasonic energy for surgical procedures.
  • ultrasonic heating is carried out of at least a portion of the blood vessel wall having the abnormality.
  • a parameter is monitored relating to a property of at least a portion of the heated portion of the blood vessel wall; and heating is stopped when the monitored parameter changes by a predetermined factor or after the monitored parameter changes at a slow enough rate.
  • Magerie and Peacock in EP 1769759 disclose an air backed ultrasonic transducer. Specifically they disclose an ultrasound transducer mounted onto a delivery member, such as the elongate body of a catheter shaft, without a support structure bridging between a separation area between the transducer and the shaft. Mounting flanges extend from either end of the transducer and are mounted at first and second locations along the catheter shaft such that the transducer is not in mechanical contact with the catheter shaft between those mounting locations to provide for air backing between the transducer and the catheter shaft so as to isolate ultrasound transmission radially away from the catheter shaft and toward the tissue surrounding the shaft. In Maguire and Peacock, sealing of the transducer ensures that body fluids such as blood do not displace the air.
  • An ultrasound transducer can in principle be used to provide a high power ultrasound beam that can ablate tissues.
  • the transformation of electrical energy into ultrasound is inefficient and considerable heat is generated at the transducer.
  • the heat needs to be safely dissipated without causing damage to the blood vessel itself, and standard heat sink structures cannot be used in blood flow because heat exchange fins can damage platelets and cause clotting.
  • the transducer may be expected to heat the artery wall as well as the more distant features it is intended to ablate.
  • ultrasound transducers are typically ceramics with piezoelectric properties. Ceramics have low thermal conductivity and thus operation at high power causes relatively large heat differentials across the transducer which often causes cracking.
  • the present embodiments may provide a transducer which carries out tissue ablation using an unfocused beam from an extended surface of the transducer.
  • the beam heats surrounding fluid and sets up a chimney effect which then serves to cool the transducer surface.
  • the use of higher frequencies, in excess of 8 Megahertz, allows for thinner transducers to be used, which reduces the likelihood that large heat differentials will form or cause cracking.
  • the thicknesses used are between 100-200 microns, and higher energies result from the higher frequencies used.
  • the ultrasonic energy may be focused or unfocussed.
  • an ultrasonic transducer device for producing ultrasonic beams, comprising a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused power beam for tissue ablation, the unfocused power beam being produced by vibration over the body of the transducer and emanating from said extensive surface, whereby the extensive surface becomes subject to convective cooling when immersed in a fluid by a chimney effect set up by said unfocused beam.
  • the device may be mounted on a PCB, wherein trenches are constructed in the PCB for fluid flow to enhance said cooling.
  • the device may comprise a pump unit for actively pumping liquid around said transducer.
  • said ultrasonic transducer device comprises a piezoelectric element and wherein said vibratable body is a body of said piezoelectric element.
  • the device may comprise an gas-filled gap between said transducer and said PCB.
  • said gas-filled gap is unsealed and wherein surface tension retains air within said gap when said device is immersed in fluid.
  • the device may comprise conductive connections to the PCB across the gas-filled gap, wherein said conductive connections provide thermal linkage between said transducer and said PCB, thereby enabling the PCB to act as an additional heat dissipation surface for said device.
  • the device may be located at a circumferential wall of a catheter or at the end of said catheter, and thermally connected to a heat sink that is located within the catheter and/or at the circumferential wall of the catheter or in the blood flow.
  • the device may be located at a circumferential wall of a catheter or at the end of said catheter, and wherein saline is pumped down the catheter to provide additional fluid flow around the transducer and/or around the heat sink.
  • the device may comprise a temperature sensor located in association with said transducer.
  • said temperature sensor is located downstream of said transducer in a flow direction of liquid in a vessel within which said device is placed, thereby to measure temperature of liquid that has passed said extensive surface.
  • the device may comprise a controller for providing said power beam in a duty cycle, said controller being configured to modify said duty cycle and/or applied power in response to changes in temperature indicated by said temperature sensor.
  • said controller is configured to modify said duty cycle to control said surface to remain within a range of 40° C. to 50° C., or at 44° C.
  • the device may be controllable to stop said power beam when a temperature sensed by said sensor reaches or exceeds a predetermined safety threshold.
  • the device may be located at the end of a catheter, and may comprise a temperature sensor located in association with said transducer, wherein saline is pumped down the catheter to provide fluid flow around the transducer and wherein a rate of pumping is controlled according to changes in temperature sensed by said temperature sensor.
  • said controller is configured to modify said rate of pumping to control said surface to remain within a range of 40° C. to 50° C., or at 44° C.
  • said power beam is provided at a frequency of at least 8 Megahertz, and said vibratable body has a thickness not exceeding 0.3 millimeters, thereby to increase heat transfer from the element.
  • An embodiment may comprise a distancing mechanism for positioning said transducer at least a minimal distance away from the cavity wall.
  • An embodiment may comprise a controllable valve openable into a body lumen for controlling fluid flow about said device.
  • An embodiment may comprise a thermoelectric, or Tec, cooler device to actively enhance cooling.
  • the device may include metal channels in a PCB, to allow liquid flow to cool the device.
  • a distancing device may distance the transducers from a vessel wall, to allow liquid flow in between the device and wall, both for cooling the device and the wall. In this way the vessel wall is not damaged by the ultrasound beam.
  • an ultrasonic transducer device for producing ultrasonic beams, comprising a body vibratable at ultrasonic frequencies and a surface for beam emanation, the device configured to produce an unfocused power beam over an extent of said surface for tissue ablation, the unfocused power beam being at a frequency of at least 8 Megahertz.
  • the device may have a thickness below 0.3 millimeters or a thickness of 0.15 millimeters, thereby to increase heat transfer from the element.
  • an ultrasonic transducer device for producing ultrasonic beams, comprising a body vibratable at ultrasonic frequencies, the device configured to produce a focused power beam for tissue ablation, the focused power beam being produced by vibration over the body of the transducer whereby a surface of said transducer becomes subject to convective cooling when immersed in a fluid by a chimney effect set up by said focused beam.
  • an ultrasonic transducer device for producing ultrasonic beams, comprising a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused power beam for tissue ablation, the unfocused power beam being produced by vibration over the body of the transducer and emanating from said extensive surface, the device further comprising a heatsink thermally coupled to said body for dissipating heat from said device.
  • said heatsink comprises braiding along a wall of a catheter to which said device is attached.
  • an ultrasonic transducer device for producing ultrasonic beams, comprising a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused power beam for tissue ablation, the unfocused power beam being produced by vibration over the body of the transducer and emanating from said extensive surface, the device further comprising a thermo-electric cooler device thermally coupled to said body for cooling said body.
  • an ultrasonic transducer device for producing ultrasonic beams, comprising a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused power beam for tissue ablation, the unfocused power beam being produced by vibration over the body of the transducer and emanating from said extensive surface, the body being mounted on a printed circuit board, and the printed circuit board having channels therein for allowing fluid flow to cool said body.
  • an ultrasonic transducer device for producing ultrasonic beams, comprising a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused power beam for tissue ablation, the unfocused power beam being produced by vibration over the body of the transducer and emanating from said extensive surface, further comprising a pump for pumping fluid around said device to cool said device.
  • An embodiment may be attached to a catheter and said pump may be located within said catheter.
  • an ultrasonic transducer device for producing ultrasonic beams, comprising a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused power beam for tissue ablation, the unfocused power beam being produced by vibration over the body of the transducer and emanating from said extensive surface, the device being insertable into vessels where flow is present, and further comprising a flow directing structure for directing said flow present in the vessel over the vibratable body and/or the heat sink in order to cool said device.
  • said flow-directing structure comprises a balloon.
  • said flow directing structure comprises a shaft and a bending zone on the shaft, the bending zone directing said flow.
  • Implementation of the method and/or system of embodiments of the invention can involve performing or completing selected tasks manually, automatically, or a combination thereof. This refers in particular to tasks involving control of the ultrasonic system.
  • selected tasks may be implemented by hardware, by software or by firmware or by a combination thereof using an operating system.
  • a data processor such as a computing platform for executing a plurality of instructions.
  • the data processor includes a volatile memory for storing instructions and/or data and/or a non-volatile storage, for example, a magnetic hard-disk and/or removable media, for storing instructions and/or data.
  • a network connection is provided as well.
  • a display and/or a user input device such as a keyboard or mouse are optionally provided as well.
  • FIG. 1 is a simplified schematic diagram of a first embodiment of an ultrasound transducer providing a power beam over a surface extent according to the present invention
  • FIG. 2 is a simplified schematic diagram illustrating the chimney effect set up by the ultrasound beam shown in FIG. 1 ;
  • FIG. 3 is a simplified diagram showing variations of a PCB on which to mount the ultrasound transducer, the PCB having channels in various configurations for improving fluid flow around the transducer, according to embodiments of the present invention
  • FIG. 4 is a simplified diagram illustrating an ultrasonic transducer in a catheter centered in a vessel or cavity using a balloon, according to embodiments of the present invention
  • FIG. 5 is a simplified diagram illustrating an ultrasonic transducer in a catheter centered in a vessel or cavity using a coiled placing wire, according to embodiments of the present invention
  • FIG. 6 is a simplified diagram illustrating an ultrasonic transducer in a catheter centered in a vessel or cavity using a placing net, according to embodiments of the present invention
  • FIG. 7 is a simplified diagram illustrating an ultrasonic transducer located in a window in the circumferential wall of a catheter, according to embodiments of the present invention.
  • FIG. 8 is a simplified block diagram illustrating a catheter and the control and operating elements that together with the catheter form an ablation system for use in embodiments of the present invention
  • FIG. 9 is a simplified flow chart illustrating a duty cycle control loop for controlling the duty cycle based on measured temperature, according to embodiments of the present invention.
  • FIG. 10 is a simplified schematic diagram illustrating a flow control device for controlling blood flow around the transducer, according to embodiments of the present invention.
  • FIG. 11 is a simplified graph showing correlation between increase of voltage and increase in temperature during operation of the power ultrasound beam according to embodiments of the present invention.
  • FIG. 12 is a simplified block diagram illustrating a variation of the device of FIG. 1 in which a thermo-electric cooler and a heat sink are used on a transducer, the transducer being mounted at a window of a catheter, according to embodiments of the present invention
  • FIGS. 13A and 13B are simplified schematic diagrams illustrating variant rectangular and other shapes shown in cross section, of a piezoelectric element for the transducer of FIG. 1 ;
  • FIG. 14 is a simplified diagram showing cylinder-based shapes shown in three dimensions of a piezoelectric element for the transducer of FIG. 1 ;
  • FIG. 15A is a side view of a series of piezoelectric elements mounted on a single mounting according to an embodiment of the present invention.
  • FIG. 15B is a view from above of an arrangement of piezoelectric elements mounted in two rows according to embodiments of the present invention.
  • FIG. 16 is a simplified schematic diagram that illustrates a series of angles and positions in relation to a body vessel and a catheter, in which the transducer can be placed by navigation;
  • FIG. 17 is a histology slide using H&E stain, and showing the thermal effect in a pig carotid artery;
  • FIG. 18 is a histology slide using H&E stain, and showing the thermal effect in a pig renal artery;
  • FIG. 19 is a histology slide wherein analysis and marking of the thermal damage area to a pig Carotid Artery is made by a trained pathologist;
  • FIG. 20 is a histology slide wherein analysis and marking of the thermal damage area to a pig Renal Artery is made by a trained pathologist;
  • FIG. 21 is a histology slide showing analysis and marking of the blocked Vasa-Vasorum, with arrows placed by a trained pathologist in a pig Carotid Artery Vasa-Vasorum in the adventitia;
  • FIG. 22 shows two histology slides with analysis and marking of the thermal damage, or nerve degeneration area, made by trained pathologist, for a pig renal artery, and nerves in adventitia.
  • the present embodiments comprise an ultrasound transducer device and cooling thereof and, more particularly, but not exclusively to the cooling of such a transducer device within a small vessel which may be filled with fluid.
  • the present embodiments may provide a transducer which carries out tissue ablation using an ultrasound beam, for example an unfocussed beam produced over the body of the transducer and emanating from an extensive surface of the transducer, as opposed to prior art focused beams which are produced in tightly defined spots.
  • the beam heats surrounding fluid opposite the extensive surface and sets up a chimney effect which provides convective cooling to the transducer extensive surface.
  • the transducer may be mounted on a PCB and trenches may be constructed in the PCB for fluid flow to enhance the cooling effect.
  • pumping methods may be used to enhance the flow of liquid around the transducer.
  • An embodiment uses an airbacked transducer in which surface tension is used to retain the air in position. Thus the transducer does not need to be sealed. Connections to the PCB across the airgap may use heat conductive materials to ensure that the PCB is in thermal contact with the transducer and thus enabling the PCB to act as an additional heat dissipation surface. A metal channel may be provided in the PCB.
  • the transducer may be located on a catheter, either at a window in the side wall of the catheter or at the distal tip of the catheter.
  • the transducer may be thermally connected to a heat sink that is located wholly or partly within the catheter.
  • the heat sink can, in some embodiments, evacuate the heat to the surroundings or to cooling liquids such as blood.
  • saline may be pumped down the catheter to provide additional fluid flow around the transducer and/or the heat sink, and the heat sink can be part of the shaft of the catheter as will be explained in greater detail below.
  • the transducer may provide a power beam and a measuring beam and a method is provided for measuring increases in temperature and stopping operation or changing the duty cycle or/and applied power if overheating is detected.
  • the power beam may be provided at frequencies at or in excess of 20 Megahertz, and using piezoelectric transducers which are below two millimeters in thickness, to avoid problems with cracking due to thermally induced stress within the transducer.
  • FIG. 1 illustrates an ultrasonic transducer device 10 for producing ultrasonic beams.
  • Device 10 comprises a body 12 which is vibratable at ultrasonic frequencies by an input electrical signal, and a surface 14 which extends over the body, for beam emanation.
  • the device may produce an unfocused power beam, indicated by arrows 16 , for tissue ablation or like purposes that require relatively high power.
  • the unfocused power beam is produced by vibration over the body 12 of the transducer and emanates from over an extent of the surface.
  • the beam heats fluid opposite the surface and because the heating effect occurs over the surface extent it sets up a chimney effect in the fluid. The extent of the surface thus becomes subject to convective cooling when immersed in a fluid and producing the power beam.
  • FIG. 2 is a simplified schematic diagram illustrating the chimney effect.
  • Liquid up against the hot surface 14 above the transducer body 12 is heated by the beam and its density is reduced causing it to be displaced by lower density cooler fluid.
  • the displacement is in the direction of arrows 18 , typically in a direction normal to the surface 12 being heated as long as the heating effect is over a surface extent. If the heating is point heating then the chimney effect is not set up. Cooler liquid is thus sucked in from the sides as indicated by arrows 20 .
  • the ultrasonic transducer device itself may be a piezoelectric element, which vibrates in response to electrical input and which produces an electrical output when itself vibrated.
  • Connection mountings 26 on the PCB are used to mount the transducer.
  • the connection mountings allow a gap 28 to be formed between the transducer and the PCB.
  • the PCB can be connected to a conductive heat pad or other heat dissipating mechanism.
  • the gap 28 may be air-filled, and may be sealed to retain the air when the device is immersed in liquid.
  • the sealing can attenuate the ultrasonic energy and thus, in an alternative embodiment the gap may be unsealed.
  • surface tension may retain air within the gap when the device is immersed in fluid.
  • the conductive connections 26 to the PCB across the airgap 28 may provide thermal conductivity as well as electrical conductivity, thereby enabling the PCB 22 to act as an additional heat dissipation surface.
  • FIG. 3 shows four exemplary structures 22 . 1 , 22 . 2 , 22 . 3 and 22 . 4 , for the PCB.
  • the PCBs 22 . 1 . . . 22 . 4 include trenches 24 .
  • the transducer is mounted between connection mountings 26 , and the trenches 24 thus pass underneath the transducer to allow fluid flow under the transducer to assist with cooling.
  • the transducer is operated in blood vessels such as arteries where there is significant fluid flow.
  • blood vessels such as arteries where there is significant fluid flow.
  • a pumping mechanism or pumping unit may be provided for actively pumping liquid around the transducer.
  • even arteries may require some augmentation to the fluid flow via artificial pumping.
  • the transducer device 10 is typically inserted into a body vessel using a catheter 40 , and in use is located at a window in the catheter, which window is in these cases on the circumferential wall close to the distal end of the catheter.
  • the device could be placed on the distal end itself of the catheter.
  • the transducer device may be thermally connected to a heat sink that is located within the catheter.
  • a heat sink typically cooling fins cannot be used in blood flow due to the danger of breaking platelets and causing thrombus, or blood clots.
  • the heat sink may be retained wholly within the catheter.
  • Saline may be pumped down the catheter to provide fluid flow around the transducer and around the heatsink.
  • Braiding may be provided in the catheter, say using copper stripes or stainless still braiding, to use the entire length of the catheter as a heat sink surface.
  • a spring 44 keeps the catheter centered with respect to the wall.
  • the spring may be made of Nitinol, a shape memory alloy which can be inserted flat and then when attaining a pre-set temperature reassumes its remembered shape.
  • a placing net is used to position the catheter with respect to the wall.
  • Distancing the transducer from the vessel wall ensures that the transducer does not directly heat the vessel wall. Furthermore the distance allows for fluid flow around the transducer and thus allows the chimney effect to occur. Furthermore the distance allows for blood flow at the wall of the vessel thus allowing the epithelium cells at the wall of the blood vessel to be cooled by the flow of blood and thus not be damaged by the heating effect of the ultrasound beam. Damaged epithelium cells are a future risk for the blood vessel. In general the thermal damage effect that the ultrasound beam uses is the denaturation of collagen, which occurs at around 55° C. The blood flow is generally sufficient to ensure that the epithelium layer does not reach this temperature.
  • FIG. 7 shows a transducer 70 mounted in a window 72 of a catheter.
  • the chimney effect around the transducer can have the additional effect of sucking in injected medication or staining substances from the catheter through the window 72 , thus improving injection efficiency.
  • a temperature sensor may be provided with the transducer. Typically, the sensor is placed just downstream of the transducer in the blood flow direction. Thus the temperature that is measured is that of liquid that has just passed the transducer surface, and increasing measured temperature may be taken as an indicator of overheating in the transducer.
  • FIG. 8 is a simplified block diagram of a system according to an embodiment of the present invention.
  • the system 110 may contain an acoustic transducer 112 , a power supply unit 114 , a control unit 116 , a pumping or circulation unit, shown as perfusion unit 118 , a balloon control unit 120 , temperature sensor 121 , and a navigating shaft 122 .
  • the navigating unit allows the acoustic element to navigate to the location or locations at which it is needed.
  • the balloon control unit controls a balloon for supporting the lumen as needed and centering the catheter as discussed.
  • the perfusion unit provides injection substances as necessary.
  • Controller 116 may vary the duty cycle of the power ultrasound beam in accordance with the temperature measured at temperature sensor 121 .
  • Controller 116 may provide the power beam in a duty cycle and/or just by controlling a level of applied power.
  • the duty cycle and/or applied power may be increased if the temperature falls, kept the same if the temperature remains constant and decreased if the temperature rises.
  • the duty cycle and/or applied power may for example be controlled to keep transducer surface 14 within a range of 40° C. to 50° C., or at 44° C., or at other temperatures as deemed appropriate.
  • the controller 116 may stop the power beam when the temperature sensed by sensor 121 reaches or exceeds a predetermined safety threshold.
  • the transducer is located in a window or at the end of a catheter, and the temperature sensor is used to control a rate at which cooling saline is pumped down the catheter to provide fluid flow around the transducer.
  • FIG. 10 in which a transducer 124 is mounted at a window of catheter 126 .
  • a valve flow control device 128 sits around the catheter and can be opened or closed to change the blood flow around the transducer.
  • contrast agents or medicines may be injected via the catheter and these too may provide an auxiliary role of helping to cool the transducer.
  • FIG. 11 shows temperature measurements in the upper graph against voltage in the lower graph for a transducer according to the present embodiments.
  • FIG. 11 shows a graph of real time measurements of voltage and temperature in the renal area. The relation between the applied voltage and the temperature can easily be observed.
  • Heat in the transducer is directly proportional to voltage.
  • heat is directly proportional to the reciprocal of impedance and to the efficiency subtracted from unity.
  • Heat is additionally proportional to the liquid flow over the transducer surface.
  • the blood flow rate may be calibrated with the heating and cooling effects. Thus it may be possible to turn on the transducer, check the temperature, check the flow rate, and then use a calibration table to provide the correct cooling.
  • FIG. 12 is a simplified diagram illustrating an embodiment of the present transducer device in which additional cooling elements are provided.
  • a transducer 134 Located at window 130 of catheter 132 , a transducer 134 is connected to a thermoelectric or peltier cooler 136 which in turn is connected to a heat sink 138 .
  • Typical dimensions for the construction are 0.8 mm overall, wherein 0.5 mm is the thickness of the heat sink.
  • the TEC and ⁇ or the heat sink may be placed in the axial direction of the catheter or as part of the catheter shaft. It is noted that if attempting to use high power ultrasound over the entire body of a piezoelectric element, there is a problem with breakage of the transducer due to thermal differences within the element. Ceramics generally have low thermal conductivity.
  • the present embodiments avoid the above problem by using relatively high frequencies, in the range of 8 or 10 to 40 MHz, which permits the use of thinner ceramics, so that the issue of thermal differences does not arise, or at least does not lead to breakage of the elements.
  • a frequency range of 10-40 MHz provides heating effects over a range of millimeters, and has been used for imaging but not at high power for ablation.
  • the thinner ceramics are less than 0.25 mm in thickness and an example uses 0.15 mm.
  • control may be achieved by managing either the duty cycle or the applied power.
  • Imaging has used unfocused beams but at low power, whereas ablation has used high power beams which have always been at lower frequencies and focused.
  • Imaging uses short pulses followed by gaps to listen to the echo.
  • Ablation uses continuous or long bursts in a duty cycle. Imaging to follow the results may be carried out during the gaps in the duty cycle.
  • the duty cycle can be changed as part of a control loop to maintain the correct temperature at the transducer surface.
  • Imaging can be used to obtain the face of the vessel or lumen wall and thus to provide a further control loop to make sure that the transducer is kept away from the wall.
  • the present embodiments relate generally to devices, parameters and methods for the treatment of tissue using ultrasonic waves in particular for heating, at a target area such as in the wall of a tube or cavity, located in the living body.
  • the treatment may involve excitation using high power acoustic energy.
  • the ultrasonic effect is achieved in such a way that there is control over the heated target tissue volume and location.
  • a controlled volume of tissue between the ultrasonic element and the target tissue is not treated. This distal effect may be achieved without the need of mechanical contact with the cavity walls.
  • Detailed application of the above includes the ability to cause moderate thermal damage within a controlled volume at the outer side of a cavity wall without damaging the inner side of the vessel, the inner side including different types of epithelium.
  • the treatment method may be applied by creating a gradient of different temperatures in the tissue by the combined effects of: heating the tissue with high power ultrasound and cooling of the tissue using conduction and convection.
  • the convection could be of natural fluid, for example blood flow, or by artificial injection of cooling liquid, for example cold saline injection. Additional temperature effects that are widely elaborated in other sources may also simultaneously influence the temperature gradient, for example—blood flow or capillary blood perfusion.
  • the heating control is performed by controlling the parameters of the ultrasonic field and the transmission protocol, including: transmission frequency, power, duty cycle and duration, as will be described in greater detail herein.
  • the treatment is controlled by feedback from the tissue using an echo received from the tissue during the treatment. Specifically, at high temperatures above 55° C. an irreversible change is created in the collagen fibers in the tissue; this change may be monitored using the ultrasonic echo from the tissue, which allows mapping of the damaged tissue area.
  • the ultrasonic transmission is applied at high power, high frequency and for more than one second.
  • Heating of the tissue in the ultrasonic field is performed by absorption of the acoustic energy in a process of dissipation of mechanical energy.
  • the absorption and influence of the energy on the tissue includes inter alia the following effects: a heating effect, a mechanical effect, a pressure effect, a sub-pressure and a cavitation effect.
  • the cooling effect is achieved by liquid flow in the vessel or fluid present (for example blood, urine, lymphatic liquid, bile) or liquid active ejection.
  • liquid flow in the vessel or fluid present for example blood, urine, lymphatic liquid, bile
  • liquid active ejection for example blood, urine, lymphatic liquid, bile
  • the present embodiments may provide the possibility of transmitting the energy to a second side of a wall without touching the wall, for example a cavity or lumen wall. By not touching it is possible to increase protection for both the elements and the non target tissue by allowing fluid to flow on the cavity walls and on the transducer surface.
  • the liquid provides for cooling.
  • the present embodiments may also allow for easier operation by not restricting the transducer location.
  • the present embodiments may transmit a non-focused acoustic field to reach the target tissue.
  • An advantage of not having to focus the field is that there is no need to control the tissue distance from the transducer.
  • renal denervation may be carried out simply by allowing the catheter to transmit a wide, high power acoustic field from a nonspecific location in the artery to a distal nonspecific location of the renal nerve.
  • Alternative embodiments may provide a focused beam at higher power.
  • Embodiments of the invention may allow ejection of materials into the treated area or to an upstream area therefrom in a way that the materials are inserted into the vessel, say through the vasa-vasorum or the adventitia lymph capillary.
  • the embodiments described herein allow sampling of the voltage created on the ultrasonic element due to echoes from the tissue and processing the data in such a way that the treated tissue is monitored.
  • Echo sampling and recording and or processing for measurement and monitoring can be performed simultaneously with the treatment.
  • Such simultaneous treatment and analysis can increase the level of control of the treatment in real time and help ensure achievement of the desired results.
  • the following information may be monitored from the echoes received within a vessel:
  • the data analysis method may include echo intensity, backscatter, spectral signature mapping, elastography, classification according to classification matrix of tissues, and the ultrasonic effect.
  • the control unit may use the above data and analysis for increasing the treatment, or reducing the treatment, or stopping the treatment, or providing indications regarding the treatment stage, or providing indications to stop or to continue the treatment.
  • a therapeutic catheter with an ultrasonic transducer may allow for transmission to the vessel from the inner side.
  • An ultrasonic transducer may be placed in proximity to a wall, with an internal catheter and transmission to the outer side of the wall. In the case of limbs one transducer can be placed externally on the outside of the skin and another in a blood vessel.
  • An endoscope system may include an ultrasonic element in its tip.
  • the endoscope may be inserted through the skin and ultrasonic transmission may be provided to the outer side of the cavity.
  • the fluid control methods may include one or more of the following implementations:
  • a restrictor around the transducer may involve: placing the transducer at a different location in the vessel, and controlling the flow;
  • a restrictor near the transducer may again involve placing the transducer at a different location in the vessel, and controlling the flow;
  • a restrictor in front of (upstream of) the transducer may involve blocking the flow upstream in order to load the vasa-vasorum with liquid and particles.
  • the method may involve blocking the flow downstream of the transducer to allow drug delivery specifically to the treated area;
  • the restrictor may be one or more of the following: a balloon, a wire, nets, or a thin plastic sheet.
  • Injecting vasoconstriction materials into the blood and in this way reducing the perfusion and heat evacuation from the tissue, or injecting or evoking micro-bubbles and increasing the heating by increasing absorption of the ultrasonic energy, or the evoked micro-bubbles may be produced by use of an additional separate transducer.
  • Micro-bubble transportation through the cell membrane may be increased using the acoustic treatment, and may achieve a multiplied effect.
  • the tissue may be cooled before treatment in order to protect and or control the treated area and non-treated area.
  • the ultrasonic field and/or the level of perfusion can be controlled and manipulated by influencing the body system in general.
  • Possible target tissues for the device include one or more of the following and their nearby tissues to douse cavities: arteries, veins, lymph vessels, intestine, esophagus, CNS, urine lumen, gall bladder lumen, Stomach, and Tear Trough.
  • Blood vessel wall pathology For example for an atherosclerotic lesion
  • Treatment of tissue near the urine lumen wall for example prostate treatment
  • Treatment of tissue far from the urine lumen wall for example prostate cancer.
  • phantom pain treatment in which, the target tissue is nerve tissue in the limbs.
  • the catheter cavity may be located in a limb artery.
  • the purpose of the treatment may be reducing phantom pain innervations by denerving the injured nerve.
  • An additional example of treatment is renal denervation.
  • the target is the renal nerves.
  • the catheter cavity is located in the renal artery.
  • the purpose is to reduce pressure on the heart for high blood pressure patients.
  • the frequency, power and acoustic beam as per the data and results hereinbelow treat the nerves without or with minimal damage to the artery.
  • the attenuation is smaller in the fatty tissue around the nerves than in the nerves themselves at the device frequencies, which increases the selectiveness of the treatment.
  • lymphocytes occurring in one or more of: lymphocytes, macrophages, smooth muscle cells, fibroblasts, endothelial cells, and neurons;
  • Reduced change in the tissue activity including: reducing smooth muscle function, reducing or blocking nerve activity, reducing or blocking the generation of the heart beat potential to the heart muscles;
  • Biochemical changing in the tissues may include: reducing or preventing plate connection to collagen, and changes of material diffusion through the cell walls.
  • the device may be operated using typical parameters for acoustic transmission as follows:
  • Transmission duration (total time): 1-120 seconds.
  • the ultrasonic elements transfer the energy to the target tissue, and may also be used as sensors for receiving reflections from the tissue.
  • the ultrasonic element may also be used as a jet evacuator of fluids for cooling or/and for drug delivery.
  • the ultrasonic element can be used as a microbubble evacuator.
  • the ultrasonic element typically includes one or more ultrasonic transducers including a piezoelectric material 24 or a MEMS element—see FIGS. 2 and 3 . Electrodes may provide power to the transducer.
  • the housing 30 protects the assembly, and an electrical connection may be provided between the electrodes and the catheter wires.
  • the transducer element 124 may, as mentioned by a piezo-electric elements or a MEMS element.
  • a PIEZO-electric transducer element may typically be made from PIEZO-electric material, for example: PZT ceramics, PIEZO-electric quartz.
  • FIG. 14A illustrates a series of shapes where the depth cross-section is rectangular as shown in element 133 .
  • Element 135 is rectangular as seen from above.
  • Element 137 is a hexagon.
  • Element 139 is an irregular quadrilateral.
  • Element 140 is a flattened circle.
  • Element 142 is a trapezium.
  • Element 144 is a bullet shape.
  • Element 146 is a trapezium having a shorter dimension between its parallel sides than the trapezium of element 142 .
  • Element 148 is a comb shape having a narrow tooth at a first end followed by three wider teeth.
  • Element 150 is a “W” shape, again with a narrow tooth projection at a first end.
  • FIG. 14B illustrates a closed ring shaped element 152 and an open ring shaped element 154 .
  • FIG. 14C illustrates four variations on a cylindrical element.
  • Element 156 is a filled cylinder.
  • Element 158 is a cylinder with a removable sector.
  • Element 160 is a hollow cylinder having an opening 161 in the lower wall, and element 162 is a hollow cylinder having an open part of the cylinder wall along its length.
  • the element 112 (as shown in FIG. 8 ) may be spherical.
  • the transducer described above does not necessarily include a focal point for the ultrasonic beam.
  • the beam can reach various targets without requiring a precise distance between the element and the target, as will be described in greater detail below.
  • Possible construction of the transducer may comprise regular coating methods for piezo elements, and coating materials including one or more of: silver, Ni, gold, copper, or carbon nano-tubes.
  • Additional coating of the electrodes may improve one or more of the following: the electric conductivity, the acoustic matching, the acoustic reflection or the acoustic amplification.
  • the additional coating may use any of a variety of materials including polymers, glass and metals.
  • the PIEZO-electric material may for example comprise: PIEZO-electric ceramics and/or PIEZO-electric quartz.
  • An embodiment as discussed hereinbelow with cooling methods may allow the design to use high hardness ceramics, which have advantages of being of high efficiency, and being small and cheap.
  • the acoustic element can also be implemented using MEMS.
  • More than one acoustic element can be implemented, for example:
  • FIG. 15A is a side view showing five piezoelectric elements 170 mounted on a curved PCB 172 .
  • FIG. 15B is a view from above showing two rows of piezoelectric elements 174 and 176 .
  • the housing can made from one or more of the following materials: metals, ceramics, PZT, PIEZO-electric ceramics, glass, polymers or carbons.
  • the housing may provide an angiogram directional projection for better placing of the element.
  • the housing may further be shaped to provide focusing or to affect fluid flow within the lumen around the element.
  • the housing may be designed to provide relatively high heat transfer from the element in order to avoid overheating.
  • the heat conductance is a function of shape and of the material used, however standard cooling fins cannot be used in the blood stream as they may cause platelets to break, thus causing blood clots.
  • the housing can include acoustic damping materials, such as tungsten, or alternatively may be designed to provide an acoustic amplifying effect. As per the discussion above, typically some of the piezoelectric surface is damped and some is provided with acoustic amplification.
  • a drug delivery capsule may be provided to inject materials into the bloodstream as required by the procedure.
  • the printed circuit may comprise materials such as hard polymers, flexible polymers, glass-fiber and carbon fiber. Alternatively, the printed circuit may be printed directly on the housing.
  • connection to the acoustic element may use any of wire soldering, paste soldering process, conductive gluing and wire bonding.
  • the connection is preferably both a good heat conductor and a good electrical conductor.
  • the circuit itself may include vias of copper or other metals for higher heat transfer.
  • One or more printed materials may be provided on the board, including: copper, metals, polymers, and intermediate materials.
  • Coatings such as metals, PZT, chemical coatings, isolation coatings, hydrophilic coatings and hydrophobic coatings may be used on different parts of the PCB or housing.
  • the acoustic transducer may be connected to the control unit 116 using different kinds of wires including: coax wire, twisted pair, and fiber optic cable.
  • the acoustic transducer and the catheter may be coated with different coatings including: an isolation coating, a praline, NiSi, hydrophobic coating, hydrophilic coating, or any kind of biocompatible coating,
  • an air pocket may be maintained between the PCB and the piezoelectric element.
  • Air pockets may be formed by the use of trenches in the PCB structure as illustrated with reference to FIG. 3 . or by providing a mounting as shown in FIG. 1 where a gap is defined between the piezoelectric element and the PCB.
  • Hydrophobic coatings including praline, may be used to enhance the surface tension effect in order to prevent the water medium from penetrating into the air volume.
  • the coating may cover the entire air bubble surrounding or part of it and prevent water from penetrating in.
  • the air bubble does not need to be maintained indefinitely. It is sufficient that it is retained for the duration of the ultrasound procedure.
  • the ultrasonic element may use different anti-resonance values for the working frequency when available. For example one anti- resonance may be used for moderate heating of the tissue, another for power heating of the tissue and yet another for monitoring.
  • the device may be able to provide an injection jet to the tissue, may provide for increasing fluid flow under the element, say to improve cooling, may evoke micro-bubbles, and may monitor the heating effect and or any injection.
  • the measurement system may include doppler analysis and the heat treatment may use focused or unfocused ultrasound.
  • the navigation unit 122 may allow the acoustic element to reach the desired location.
  • the navigation unit may further have some auxiliary functions. For example it may deliver the power to the element from the control unit, record measurements from the element and even deliver the measurements to the control unit 116 .
  • the navigation unit may further be involved in heat absorption or transfer from the transducer to the ambient or to the surrounding liquids by providing an additional heat exchange surface extending from the catheter.
  • the navigation unit may also mechanically hold and place the ultrasonic elements in different locations and at different desired angles, as per FIG. 16 .
  • a ring configuration 180 may be used, or an angle configuration 182 , or a cylindrical configuration 184 or a side configuration 186 or a front configuration 188 , each in relation to the catheter.
  • the navigation unit may include an external navigated control unit.
  • a placing unit may include a balloon, a placing wire or a net or the like.
  • a heat sink function may including cooling the ultrasonic unit using outside fluid including: blood, urine or CSF.
  • the function may include increasing the heat evacuation by pumping fluid over or from the acoustic unit surface.
  • the function may involve increasing the heat evacuation using internal or external heat conductive material, including: blood passivation coating, or printed coating, or may include increasing the heat evacuation using an internal or external heat conductive balloon.
  • Heat evacuation may be increased by using an internal or external heat conductive balloon with heat conduction material.
  • the control unit 116 may provide various kinds of closed loop control and indications on the treatments.
  • the control unit may receive signals from echoes from the tissue.
  • the echo may indicate the area and treatment effect, or the echo can indicate the distance from the cavity wall to the transducer device.
  • the sensor may be a temperature sensor, which may indirectly sense the temperature of the transducer by measuring fluid that has just passed the sensor.
  • the temperature may indicate the treatment efficiency, or efficiency of cooling of the cavity, or the cooling or heating of the transducer.
  • a power sensor can indicate the output treatment energy.
  • a blood pressure sensor or other like sensors may be provided to indicate reaction to the treatment.
  • a flow sensor can monitor fluid flow in the region of the treatment.
  • Closed loop effects which do not require the control unit may also be used, as known to the skilled person, for example a coating material on the transducer surface may be provided that attaches to particles or other materials that come from the treated tissue.
  • the attachment may be used to control the ultrasonic process by making changes to the transducer frequency during operation.
  • Materials that can be inserted into the target tissue volume include restenosis prevention materials, for treatment of blood vessels, and materials that are used in drug eluting stents, such as sirolimus, and paclitaxel.
  • Other materials can be used, say in drug exuding and eluding balloons, and may include materials that are used for bio-degradable stents, anti-Inflammatory materials, medications that may be better presented locally to the tissue than systemically, anti-thrombotic materials, such as Heparin, Aspirin, Ticlopidine, and Clopidogrel, and materials that can cause damage or death to target tissues.
  • anti-thrombotic materials such as Heparin, Aspirin, Ticlopidine, and Clopidogrel
  • materials that can cause damage or death to target tissues may be supplied for renal denervation.
  • materials that may help in blocking of the tissue micro-circulation in heating such as polymers that undergo cross linking, or soluble collagen, or material that may increase the ultrasonic heating of the tissue, such as micro-bubbles that cause higher energy absorption, may be used, or in the latter case generated on site.
  • Micro-bubble transportation through the cells membrane can be increased using the acoustic treatment, and achieve a multiplicative effect.
  • any kind of medication can be applied.
  • the transducer may be positioned on a catheter inside blood-vessels or blood cavities. Ultrasonic irradiation of the target tissue from inside the vessel lumen or cavity outwards may then be provided. Cooling of the piezoelectric element may be achieved by making the design sufficiently conductive and then using blood flow or flow of a fluid from an external source, such as saline that is irrigated into the blood vessel.
  • an external source such as saline that is irrigated into the blood vessel.
  • the transducer may be positioned on a catheter inside tissue canals or cavities of body fluids in the body, such as the urethra or urinary bladder, or in the spinal cord or brain ventricles (CNS fluid). Ultrasonic irradiation of the target tissue from inside the canal/cavity outwards may then be provided.
  • the transducer may alternatively be positioned on the tip of an endoscope or like device.
  • the endoscope is inserted through a small hole in the skin, and the ultrasonic transducer is positioned on or near the target tissue.
  • the endoscope tip may for example be positioned inside a balloon like device.
  • the cooling fluid flows inside the balloon.
  • the balloon is positioned next to the treatment tissue location.
  • the ultrasonic transducer irradiates the target tissue through the balloon wall.
  • the balloon may be positioned on the skin and not inserted through it.
  • the treatment target may be near the skin.
  • the ultrasonic transducer may be positioned at a location that allows ultrasonic irradiation of the target tissue. Irrigation of required material in a liquid form may be provided into the blood vessels or lymphatic vessels that supply the perfusion or lymphatic capillaries of the target tissue volume, for example the artery vasa-vasorum.
  • the method may involve waiting a known time constant for the required material to reach the target tissue.
  • micro-bubbles may be detected using ultrasound and sub-harmonic imaging. Micro-bubbles may also improve heating of the target tissue under ultrasonic energy, due to higher absorption of the ultrasonic energy in the tissue volume where they are located.
  • Applying a thermal effect in the tissue may cause the capillaries to be blocked mechanically or by blood coagulation.
  • Ultrasound energy applies mechanical force on particles that are present in a liquid, when there is a difference in the acoustic impedance, which is a function of the density multiplied by the speed of sound, between the particles and the liquid.
  • the applied force then pushes particles along the direction of the traveling ultrasonic waves.
  • the mechanical force phenomenon can be used to ensure that required substances arrive at the treatment site.
  • the ultrasonic transducer may be positioned in a tissue liquid cavity such as a blood vessel, near the target tissue, while ensuring a liquid spacing between the target tissue and the ultrasonic transducer irradiating face.
  • a control loop can be used to ensure that the transducer does not touch the vessel wall and damage epithelium cells.
  • the required material may be released into the tissue liquid cavity in a way that will cause some of the particles to enter the spacing between the target tissue and the ultrasonic transducer irradiating face.
  • One way of doing this is to coat the face of the ultrasonic transducer with the required material, such that the operation of the ultrasonic transducer may cause particles of the required material to be released into the surrounding liquid.
  • micro-bubbles may be added to the required material fluid in order to detect the material presence in the target tissue.
  • Micro-bubbles may be detected using ultrasound and sub-harmonic imaging.
  • Yet another possibility is to activate the ultrasonic transducer so as to apply force on the required material particles to push the particles into the blood vessel wall near the ultrasonic transducer irradiating face, using the pushing effect mentioned above.
  • Another possibility is to apply the ultrasonic energy in short high power pulses with long separations between each pulse. This may apply mechanical force, as per the phenomenon discussed above, to the particles to push them into the tissue wall, without heating the tissue wall extensively.
  • activation of the captured required material can be achieved by applying additional ultrasonic energy or some other kind of external energy such as a magnetic field on Ferro-electric particles, or an ultrasonic shock-wave to the particles
  • the present embodiments may be used for the treatment of renal denervation.
  • the transducer is simply positioned at 1, 2 or more treatment points, and there is no need for tip manipulation or accurate positioning.
  • the total energizing duration may be between 2 seconds and 2 minutes at each point.
  • Real-time feedback of treatment progress may be provided.
  • the advantages of ultrasonic treatment include directional, localized and remote target tissue effects with minimal damage to other closer tissues, possibly reducing pain, preservation of endothelium and elastic lamina structure and function, so that there is no post treatment stenosis, or at least reduced post treatment stenosis, the avoidance of any mechanical contact on the blood vessel wall, and overall a more robust treatment effect due to real-time feedback.
  • Plaque thrombosis All relevant arteries Artery media decrease and adventitia 11. Tetanic limb muscle Limb arteries or Peripheral motor tonus decrease veins nerves 12. Atrial fibrillation Right atria Pulmonary prevention vain insertion 13. Cardiac arrhythmia Coronary arteries Cardiac tissue prevention pathology 14. Liver tumor necrosis Inferior vena cava Tumor 15. None-malignant Urethra Sick prostate prostate treatment tissue 16. Malignant prostate Urethra Sick prostate treatment tissue 17. Artery aneurysms All relevant arteries Aneurysm wall stabilization 18. Aortic aneurysms Aorta Aneurysm wall stabilization 19. Berry aneurysms Brain arteries Aneurysm wall sealing 20. Erectile dysfunction Internal Iliac Artery media treatment and adventitia 11.
  • the ultrasonic transducer 1.1.1. Very small: 1.5 ⁇ 8 [mm] 1.1.2. Very thin: 0.8 [mm] 1.1.3. Very high ultrasonic intensity output: 100 [W/cm ⁇ circumflex over ( ) ⁇ 2] 1.1.4. Relatively high work frequencies: 10-25 [MHz]. 1.1.5. Biocompatible coating: Perylene 1.2. The catheter 1.2.1. Ultrasonic transducer cooling: vessel blood/liquid flow + catheter breading as heat sink 1.2.2. Very flexible treatment tip: 10 mm stiff length. (Pass through 8 Fr “hokey-stick” guide catheter) 1.2.3. Precise and easy torque following 1.2.4. Standard 0.014 OTW 1.2.5. Relatively small diameter: 6 Fr 1.3.
  • Distancing fixture 1.3.1. Distancing transducer face from artery wall to prevent contact damage, with minimal mechanical forces on artery wall 2.
  • Technology functionality 2.1. Non-focused ultrasonic beam-like ultrasonic emission 2.1.1. Simple anatomic 2.1.2. Big treatment volume cross-section, the size of the transducer face (differing from focused ultrasound with small treatment volume) 2.1.3. Relatively even spread of ultrasonic energy in beam cross-section (No need to precise anatomic positioning like in focused ultrasound) 2.2. Treatment maneuverability and directionality 2.2.1. Simple maneuvering with nearly 1:1 torquability.
  • FIGS. 17-22 illustrate experimental results following use of the device.
  • FIG. 17 is a histology slide, using H&E stain, and showing the thermal effect in a pig carotid artery.
  • the border of the thermal effect region in the tissue is marked with a dashed line and noted as “Thermal Damage”.
  • the setup used was an ultrasonic catheter from inside the blood vessel.
  • FIG. 18 is a histology slide, using H&E stain, and showing the thermal effect in a pig renal artery.
  • the border of the thermal effect region in the tissue is marked with a dashed line and noted as “Thermal”.
  • a necrotic nerve inside the thermal effect region is marked with an arrow and “necrotic nerve” text.
  • the setup involved an ultrasonic catheter from inside the blood vessel.
  • the embodiments cause thermal damage in target tissues far from the lumen internal wall, while causing no thermal damage in the lumen wall internal layer.
  • the reason for this effect is that the ultrasonic energy heats the artery wall all along the beam, but the blood flow in the lumen cools the tissue that is close to the blood flow, thus the endothelium wall never heats sufficiently to be damaged. It is possible to find a setting for the treatment parameters so to cause heating above 55C of the tissues far from the blood flow, while the temperature of the intima layer is kept below 55C.
  • FIGS. 19 and 20 are histology slides wherein analysis and marking of the thermal damage area to a pig Carotid Artery and a Pig Renal Artery respectively, is made by a trained pathologist.
  • Heating the adventitia or media can cause blocking of the flow inside the small capillaries (called Vasa-Vasorum) in the blood vessel media and adventitia, for example by mechanical crimping due to the shrinking of the connective tissue due to collagen denaturation, or due to thrombotic blocking by a thrombus that is formed in the Vasa-Vasorum because of the thermal damage (the blood flow in these vessels is very low so it can not cool the blood vessel).
  • Vasa-Vasorum small capillaries
  • Heating the adventitia or media can cause blocking of the flow inside the small capillaries (called Vasa-Vasorum) in the blood vessel media and adventitia, for example by mechanical crimping due to the shrinking of the connective tissue due to collagen denaturation, or due to thrombotic blocking by a thrombus that is formed in the Vasa-Vasorum because of the thermal damage (the blood flow in these vessels is very low so it can not cool the blood vessel).
  • FIG. 21 illustrates exemplary results for the above.
  • a histology slide shows analysis and marking of the blocked Vasa-Vasorum with arrows placed by a trained pathologist in a pig Carotid Artery Vasa-Vasorum in the adventitia.
  • the treatment is intended to provide extensive thermal damage to specific target tissues while keeping nearby tissues undamaged.
  • the ultrasonic energy absorption is different for different kinds of tissue and, and furthermore, the content of collagen fibers may differ.
  • FIG. 22 illustrates two histology slides with analysis and marking of the thermal damage, or nerve degeneration area made by a trained pathologist, for a pig renal artery, and nerves in adventitia.

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Priority Applications (7)

Application Number Priority Date Filing Date Title
US13/049,022 US20120095371A1 (en) 2010-10-18 2011-03-16 Ultrasound transducer and cooling thereof
EP11782223.9A EP2629848B1 (fr) 2010-10-18 2011-10-18 Emetteur-récepteur d'ultrasons et maîtrise d'un processus d'endommagement thermique
US13/880,083 US20130204242A1 (en) 2010-10-18 2011-10-18 Ultrasound transceiver and control of a thermal damage process
EP11785792.0A EP2629849A1 (fr) 2010-10-18 2011-10-18 Emetteur-récepteur d'ultrasons et son refroidissement
US13/879,400 US9566456B2 (en) 2010-10-18 2011-10-18 Ultrasound transceiver and cooling thereof
PCT/IB2011/054639 WO2012052925A1 (fr) 2010-10-18 2011-10-18 Emetteur-récepteur d'ultrasons et maîtrise d'un processus d'endommagement thermique
PCT/IB2011/054641 WO2012052927A1 (fr) 2010-10-18 2011-10-18 Emetteur-récepteur d'ultrasons et son refroidissement

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US20140180197A1 (en) 2014-06-26
US20120095335A1 (en) 2012-04-19
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EP2629681A1 (fr) 2013-08-28
JP2013543422A (ja) 2013-12-05
US8696581B2 (en) 2014-04-15
US20140039477A1 (en) 2014-02-06
US9326786B2 (en) 2016-05-03
WO2012052922A1 (fr) 2012-04-26
WO2012052921A1 (fr) 2012-04-26
EP2629849A1 (fr) 2013-08-28
US10368893B2 (en) 2019-08-06
EP2629681B1 (fr) 2017-07-12
CN103260532B (zh) 2015-09-16
US11730506B2 (en) 2023-08-22
CN103260532A (zh) 2013-08-21
US20190308003A1 (en) 2019-10-10
US8585601B2 (en) 2013-11-19
EP2629683A1 (fr) 2013-08-28
US20120095372A1 (en) 2012-04-19
US20230389954A1 (en) 2023-12-07
US20130211437A1 (en) 2013-08-15

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