US20120093914A1 - Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration - Google Patents
Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration Download PDFInfo
- Publication number
- US20120093914A1 US20120093914A1 US13/130,969 US200913130969A US2012093914A1 US 20120093914 A1 US20120093914 A1 US 20120093914A1 US 200913130969 A US200913130969 A US 200913130969A US 2012093914 A1 US2012093914 A1 US 2012093914A1
- Authority
- US
- United States
- Prior art keywords
- matrix
- liposomes
- cells
- cell
- canceled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- XYFQFTADQKBNGU-UHFFFAOYSA-N C.C.COCCCCCC(C)=O.O=C(CCCCCO)OCCCCCC(=O)O=C=OC(=O)CCCCCOC(=O)CCCCCO Chemical compound C.C.COCCCCCC(C)=O.O=C(CCCCCO)OCCCCCC(=O)O=C=OC(=O)CCCCCOC(=O)CCCCCO XYFQFTADQKBNGU-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/626—Liposomes, micelles, vesicles
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Definitions
- the PCL particles are embedded within a hydrogel matrix such as collagen or hyaluronic acid that help hold the particles in place following their delivery in the body.
- a hydrogel matrix such as collagen or hyaluronic acid that help hold the particles in place following their delivery in the body.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/130,969 US20120093914A1 (en) | 2008-11-24 | 2009-11-24 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20021308P | 2008-11-24 | 2008-11-24 | |
US20020808P | 2008-11-24 | 2008-11-24 | |
US20021408P | 2008-11-24 | 2008-11-24 | |
US20020708P | 2008-11-24 | 2008-11-24 | |
US13/130,969 US20120093914A1 (en) | 2008-11-24 | 2009-11-24 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration |
PCT/US2009/065797 WO2010060104A2 (en) | 2008-11-24 | 2009-11-24 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone praticles as scaffolds for tissue regeneration |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/065797 A-371-Of-International WO2010060104A2 (en) | 2008-11-24 | 2009-11-24 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone praticles as scaffolds for tissue regeneration |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/531,340 Division US9889232B2 (en) | 2008-11-24 | 2014-11-03 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
US20120093914A1 true US20120093914A1 (en) | 2012-04-19 |
Family
ID=42198860
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/130,969 Abandoned US20120093914A1 (en) | 2008-11-24 | 2009-11-24 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration |
US14/531,340 Active US9889232B2 (en) | 2008-11-24 | 2014-11-03 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/531,340 Active US9889232B2 (en) | 2008-11-24 | 2014-11-03 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration |
Country Status (5)
Country | Link |
---|---|
US (2) | US20120093914A1 (de) |
EP (1) | EP2370112B1 (de) |
CA (1) | CA2781591A1 (de) |
DK (1) | DK2370112T3 (de) |
WO (1) | WO2010060104A2 (de) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013151725A1 (en) | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Regenerative sera cells and mesenchymal stem cells |
WO2015136479A1 (en) * | 2014-03-12 | 2015-09-17 | Glaxosmithkline Biologicals S.A. | Liposomal compositions for mucosal delivery |
US20170157048A1 (en) * | 2014-06-04 | 2017-06-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
US10837018B2 (en) | 2013-07-25 | 2020-11-17 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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US6876636B2 (en) | 2002-07-09 | 2005-04-05 | Qualcomm Inc. | Method and system for a multicast service initiation in a communication system |
WO2011078990A1 (en) * | 2009-12-14 | 2011-06-30 | Benaroya Research Institute At Virginia Mason | Hydrogels comprising hyaluronan and at least one t cell induction agent |
ITMI20111009A1 (it) | 2011-06-01 | 2012-12-02 | Milano Politecnico | Idrogeli di gelatina reticolata |
TWI449546B (zh) * | 2011-09-07 | 2014-08-21 | Ind Tech Res Inst | 應用於軟硬組織修復與再生之生醫材料 |
JP6408469B2 (ja) * | 2012-09-06 | 2018-10-17 | ナンヤン テクノロジカル ユニヴァーシティー | ヒアルロン酸をベースとする薬物送達システム |
GB201301571D0 (en) * | 2012-11-27 | 2013-03-13 | Fundanci N Pedro Barri De La Maza | Product and use |
EP2918262B1 (de) * | 2014-03-10 | 2023-08-09 | PLS-Design GmbH | Induktion einer antigenspezifischen Toleranz durch periphere Phagozytose |
EP3095440B1 (de) * | 2015-05-19 | 2020-01-15 | PLS-Design GmbH | Antigen-spezifische immuntherapie mit toleranzinduzierenden liposomen |
EP3454839A4 (de) * | 2016-05-12 | 2020-02-12 | Insitu Biologics, Inc. | Hydrogelbasiertes vehikel zur freisetzung eines biologikums |
WO2019032585A1 (en) * | 2017-08-09 | 2019-02-14 | The Regents Of The University Of Michigan | STRUCTURES IMITATING APOPTOSIS |
CN107496348A (zh) * | 2017-08-28 | 2017-12-22 | 天津昂赛细胞基因工程有限公司 | 一种用于组织损伤修复的水凝胶及制备方法 |
CN109337877B (zh) * | 2018-10-31 | 2021-11-12 | 安徽农业大学 | 二氯苯酚降解酶TcpA及其编码基因与生产菌的应用 |
CN110327498B (zh) * | 2019-04-15 | 2021-02-02 | 北京大学口腔医学院 | 一种基于脂质体的活性小分子控释方法及其应用 |
CN116603076B (zh) * | 2023-07-13 | 2023-10-10 | 四川大学华西医院 | 一种具有超疏水性能的药物结构涂层及其制备方法 |
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US20050069518A1 (en) * | 2003-02-12 | 2005-03-31 | Shaker Mousa | Method for treating occlusive vascular diseases & wound healing |
US20060228417A1 (en) * | 2003-07-31 | 2006-10-12 | Pascale Hubert | Mucoadhesive composition comprising polyacrylate and chemoattractant |
US20070148220A1 (en) * | 2003-12-23 | 2007-06-28 | Mueller Rolf | Liposomes and liposomal compositions for vaccination and drug delivery |
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ATE198979T1 (de) * | 1994-10-12 | 2001-02-15 | Focal Inc | Zielgerichte verabreichung mittels biologisch abbaubarer polymere |
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US6267955B1 (en) | 1995-09-15 | 2001-07-31 | Yeda Research And Development Co. Ltd. | Mononuclear phagocytes and their use to promote axonal regeneration |
US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
WO2001054735A2 (en) * | 2000-01-28 | 2001-08-02 | Orthogene, Inc. | Gel-infused sponges for tissue repair and augmentation |
US20020034501A1 (en) * | 2000-05-18 | 2002-03-21 | Robert Pawliuk | Methods and compositions for promoting angiogenesis using monocytes |
EP1438413A4 (de) * | 2001-10-03 | 2006-06-07 | Selective Genetics Inc | Einen flüssigkeitsraum durchquerende nukleinsäuremoleküle und expression in reparaturzellen |
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WO2013151725A1 (en) | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Regenerative sera cells and mesenchymal stem cells |
US10837018B2 (en) | 2013-07-25 | 2020-11-17 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
US10894963B2 (en) | 2013-07-25 | 2021-01-19 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
WO2015136479A1 (en) * | 2014-03-12 | 2015-09-17 | Glaxosmithkline Biologicals S.A. | Liposomal compositions for mucosal delivery |
BE1022346B1 (fr) * | 2014-03-12 | 2016-03-25 | Glaxosmithkline Biologicals S.A. | Compositions liposomales pour une administration mucosale |
US20170157048A1 (en) * | 2014-06-04 | 2017-06-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
US10434064B2 (en) * | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
US11123294B2 (en) * | 2014-06-04 | 2021-09-21 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
US11957788B2 (en) | 2014-06-04 | 2024-04-16 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
Also Published As
Publication number | Publication date |
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WO2010060104A2 (en) | 2010-05-27 |
DK2370112T3 (en) | 2017-07-24 |
CA2781591A1 (en) | 2010-05-27 |
EP2370112A4 (de) | 2013-04-10 |
WO2010060104A3 (en) | 2010-10-28 |
EP2370112A2 (de) | 2011-10-05 |
US9889232B2 (en) | 2018-02-13 |
US20150050332A1 (en) | 2015-02-19 |
EP2370112B1 (de) | 2017-04-05 |
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