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Accommodating Intraocular Lens

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US20100228344A1
US20100228344A1 US12782644 US78264410A US2010228344A1 US 20100228344 A1 US20100228344 A1 US 20100228344A1 US 12782644 US12782644 US 12782644 US 78264410 A US78264410 A US 78264410A US 2010228344 A1 US2010228344 A1 US 2010228344A1
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lens
capsular
fig
shape
portion
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Abandoned
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US12782644
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John H. Shadduck
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PowerVision Inc
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PowerVision Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1635Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1601Lens body having features to facilitate aqueous fluid flow across the intraocular lens, e.g. for pressure equalization or nutrient delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648Multipart lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1694Capsular bag spreaders therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/1681Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/1682Intraocular lenses having supporting structure for lens, e.g. haptics having mechanical force transfer mechanism to the lens, e.g. for accommodating lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/1681Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/16901Supporting structure conforms to shape of capsular bag
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0003Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having an inflatable pocket filled with fluid, e.g. liquid or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00023Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Abstract

A deformable intracapsular implant device for shaping an enucleated lens capsule sac for use in cataract procedures and refractive lensectomy procedures. In one embodiment, the intraocular implant devices rely on thin film shape memory alloys and combine with the post-phaco capsular sac to provide a biomimetic complex that can mimic the energy-absorbing and energy-releasing characteristics of a young accommodative lens capsule. In another embodiment, the capsular shaping body is combined with an adaptive optic. The peripheral capsular shaping body carries at least one fluid-filled interior chamber that communicates with a space in a adaptive optic portion that has a deformable lens surface. The flexing of the peripheral shaping body in response to zonular tensioning and de-tensioning provides an inventive adaptive optics mechanism wherein fluid media flows between the respective chambers “adapts” the optic to increase and decrease the power thereof. In one embodiment, the capsular shaping body carries a posterior negative power adaptive optic that can be altered in power during accommodation to cooperate with an independent drop-in exchangeable intraocular lens.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    This application is a continuation of pending U.S. application Ser. No. 10/358,038, filed Feb. 3, 2003, titled “Intraocular Implant Devices”, which claims benefit under 35 U.S.C. §119(e) of Provisional Patent Application No. 60/353,847 filed Feb. 2, 2002 titled “Intraocular Lens and Method of Making”; and also claims benefit of the following other Provisional Patent Applications: No. 60/362,303 filed Mar. 6, 2002 titled “Intraocular Lens and Method of Making”; No. 60/378,600 filed May 7, 2002 titled “Intraocular Devices and Methods of Making”; No. 60/405,471 filed Aug. 23, 2002 titled “Intraocular Implant Devices and Methods of Making”, No. 60/408,019 filed Sep. 3, 2002 titled “Intraocular Lens”, and No. 60/431,110 filed Dec. 4, 2002 titled “Intraocular Implant Devices and Methods of Making”. All of the above applications are incorporated herein in their entirety by this reference.
  • BACKGROUND OF THE INVENTION
  • [0002]
    1. Field of the Invention
  • [0003]
    The present invention is directed to intraocular implant devices and more specifically to shape memory capsular shaping devices for combining with a post-phacoemulsification capsular sac to provide a biomimetic complex that can mimic the energy-absorbing and energy-releasing characteristics of a natural young accommodative lens capsule. The shape memory capsular shaping devices can further be combined with an independent or integrated optics to provide an accommodating intraocular lens.
  • [0004]
    2. Description of the Related Art
  • [0005]
    The human lens capsule can be afflicted with several disorders that degrade its functioning in the vision system. The most common lens disorder is a cataract which consists of the opacification of the normally clear, natural crystalline lens matrix in a human eye. The opacification usually results from the aging process but can also be caused by heredity or diabetes. FIG. 1A illustrates a lens capsule comprising a capsular sac with an opacified crystalline lens nucleus. In a typical cataract procedure as performed today, the patient's opaque crystalline lens is replaced with a clear lens implant or IOL. (See FIGS. 1A and 1B.) The vast majority of cataract patients must wear prescription eyeglasses following surgery to see properly. The IOLs in use today provide the eye with a fixed focal length, wherein focusing on both close-up objects and distant objects is not possible. Intraocular lens implantation for cataracts is the most commonly performed surgical procedure in elderly patients in the U.S. Nearly three million cataract surgeries are performed each year in the U.S., with an additional 2.5 million surgeries in Europe and Asia.
  • [0006]
    Mechanisms of Accommodation. Referring to FIG. 1A, the human eye defines an anterior chamber 10 between the cornea 12 and iris 14 and a posterior chamber 20 between the iris and the lens capsule 102. The vitreous chamber 30 lies behind the lens capsule. The lens capsule 102 that contains the crystalline lens matrix LM or nucleus has an equator that is attached to cobweb-like zonular ligaments ZL that extend generally radially outward to the ciliary muscle attachments. The lens capsule 102 has transparent flexible anterior and posterior walls or capsular membranes that contain the crystalline lens matrix LM.
  • [0007]
    Accommodation occurs when the ciliary muscle CM contracts to thereby release the resting zonular tension on the equatorial region of the lens capsule 102. The release of zonular tension allows the inherent elasticity of the lens capsule to alter it to a more globular or spherical shape, with increased surface curvatures of both the anterior and posterior lenticular surfaces. The lens capsule together with the crystalline lens matrix and its internal pressure provides the lens with a resilient shape that is more spherical in an untensioned state. Ultrasound biomicroscopic (UBM) images also show that the apex of the ciliary muscle moves anteriorly and inward—at the same time that the equatorial edge the lens capsule moves inwardly from the sclera during accommodation.
  • [0008]
    When the ciliary muscle is relaxed, the muscle in combination with the elasticity of the choroid and posterior zonular fibers moves the ciliary muscle into the unaccommodated configuration, which is posterior and radially outward from the accommodated configuration. The radial outward movement of the ciliary muscles creates zonular tension on the lens capsule to stretch the equatorial region of lens toward the sclera. The disaccommodation mechanism flattens the lens and reduces the lens curvature (both anterior and posterior). Such natural accommodative capability thus involves contraction and relaxation of the ciliary muscles by the brain to alter the shape of the lens to the appropriate refractive parameters for focusing the light rays entering the eye on the retina—to provide both near vision and distant vision.
  • [0009]
    In conventional cataract surgery as depicted in FIGS. 1B and 1C, the crystalline lens matrix is removed leaving intact only the thin walls of the anterior and posterior capsules—together with zonular ligament connections to the ciliary muscles. The crystalline lens core is removed by phacoemulsification through a curvilinear capsularrhexis as illustrated in FIG. 1B, i.e., the removal of an anterior portion of the capsular sac. FIG. 1B then depicts a conventional 3-piece IOL just after implantation in the capsular sac.
  • [0010]
    FIG. 1C next illustrates the capsular sac and the prior art 3-piece IOL after a healing period of a few days to weeks. It can be seen that the capsular sac effectively shrink-wraps around the IOL due to the capsularrhexis, the collapse of the walls of the sac and subsequent fibrosis. As can be easily understood from FIGS. 1B and 1C, cataract surgery as practiced today causes the irretrievable loss of most of the eye's natural structures that provide accommodation. The crystalline lens matrix is completely lost—and the integrity of the capsular sac is reduced by the capsularrhexis. The shrink-wrap of the capsular sac around the IOL damages the zonule complex, and thereafter it is believed that the ciliary muscles will atrophy.
  • [0011]
    Prior Art Pseudo-Accommodative Lens Devices. At least one commercially available IOL, and others in clinical trials, are claimed to “accommodate” even though the capsular sac shrink-wraps around the IOL as shown in FIG. 1C. If any such prior art lens provide variable focusing power, it is better described as pseudo-accommodation since all the eye's natural accommodation mechanisms of changing the shape of the lens capsule are not functioning. Perhaps the most widely known of the pseudo-accommodative IOLs is a design patented by Cumming which is described in patent disclosures as having hinged haptics that are claimed to flex even after the capsular sac is shrink-wrapped around the haptics. Cumming's patents (e.g., U.S. Pat. Nos. 5,496,366; 5,674,282; 6,197,059; 6,322,589; 6,342,073; 6,387,126) describe the hinged haptics as allowing the lens element to be translated forward and backward in response to ciliary muscle contraction and relaxation within the shrink-wrapped capsule. The Cumming IOL design is being commercialized by C&C Vision, 6 Journey, Ste. 270, Aliso Viejo, Calif. 92656 as the CrystaLens AT-45. However, the medical monitor for the CrystaLens AT-45 in Phase I FDA trials explained in an American Society of Cataract and Refractive Surgeons (ASCRS) presentation, when asked about movement of AT-45's hinged haptics, that the AT-45 was not “moving much” at the optic and hinge. It is accepted that the movement of such a lens is entirely pseudoaccommodative and depends on vitreous displacement that pushes the entire IOL slightly anteriorly (see: http://www.candcvision.com/ASCRSCCTa-lks/Slade/Slade.htm). A similar IOL that is implanted in a shrink-wrapped capsule and in sold in Europe by HumanOptics, Spardorfer Strasse 150, 90154 Erlangen, Germany. The HumanOptics lens is the Akkommodative 1CU which is not available in the U.S., due to lack of FDA approval. In sum, any prior art IOLs that are implanted in an enucleated, shrink-wrapped lens capsule probably are not flexed by ciliary muscle relaxation, and exhibit only a pseudo-accommodative response due to vitreous displacement.
  • [0012]
    Since surgeons began using IOLs widely in the 1970's, IOL design and surgical techniques for IOL implantation have undergone a continuous evolution. While less invasive techniques for IOL implantation and new IOL materials technologies have evolved rapidly in the several years, there has been no real development of technologies for combining the capsular sac with biocompatible materials to provide a biomimetic capsular complex. What has stalled all innovations in designing a truly resilient (variable-focus) post-phaco lens capsule has been is the lack of sophisticated materials.
  • [0013]
    What has been needed are materials and intraocular devices that be introduced into an enucleated lens capsule with a 1 mm. to 2.5 mm. injector, wherein the deployed device and material provide the exact strain-absorbing properties and strain-releasing properties needed to cooperate with natural zonular tensioning forces. Such an intraocular device will allow for the design of dynamic IOLs that can replicate natural accommodation. Microdevices of intelligent elastic composite materials can provide the enabling technology to develop new classes of accommodating IOL systems.
  • SUMMARY OF THE INVENTION
  • [0014]
    This invention relates to novel shape memory devices, materials and capsular shaping elements (CSEs) that can be implanted using conventional techniques to create a biomimetic lens capsule complex. The capsular shaping element, or more specifically an intracapsular implant, is designed to provide the implant/lens capsule complex with a shape and resiliency that mimics the elasticity of a young, still-accommodative lens capsule. In one embodiment, the capsular shaping element incorporates at least one thin-film expanse of a shape memory alloy (SMA) material in a three dimensional shape to impart the required elasticity to the CSE. The capsular shaping element will enable, and can be integrated with, several classes of optic elements to provide an accommodative IOL system that cooperates with ciliary muscle tensioning and detensioning to provide variable focusing power. The accommodating IOL corresponding to the invention can be used following typical cataract surgeries, or can be used in refractive lensectomy procedures to treat presbyopia.
  • [0015]
    In a preferred embodiment, the capsular shaping element incorporates a least one formed expanse of thin-film nickel titanium alloy (NiTi or Nitinol). Nitinol materials have the unique capability to absorb energy by a reversible crystalline transformation (superelasticity) which is orders of magnitude higher than can be absorbed in plastic deformations of conventional resilient materials, such as a polymers used in other so-called accommodating IOL designs. In addition, such NiTi materials have the ability to avoid localization of plastic deformations—and thus can spread the absorbed energy over a much larger region of the material. Further, a capsular shaping element that relies on NiTi for its shape memory characteristics need only be microns in thickness for compacted introduction into the lens capsule. The implant, in fact, may be little thicker than the lens capsule itself. Nickel titanium alloys are also known to be biocompatible. In preferred variants of biomimetic CSEs described herein, the implant carries at least one seamless expanse of thin-film NiTi material that three dimensionally formed to engage the anterior and posterior capsules—while leaving an open central optic zone. Various types of optic elements can be coupled to the capsular shaping element of the invention.
  • [0016]
    In such preferred embodiments, the capsular shaping body also comprises in part a shape memory polymer (SMP) component that encases the shape memory alloy form, whether of a thin film SMA or another formed structure of a nickel titanium alloy. The shape memory polymer is capable of a memory shape as well as a compacted temporary shape. In its temporary compacted shape, the polymer together with the embedded superelastic nickel titanium can be ultrathin and three dimensionally stable to be rollable for use in standard diameter injector or even a sub-1 mm. injector.
  • [0017]
    In another preferred embodiment, the non-optic or peripheral body portion of the implant is again of a shape memory polymer, and optional SMA form, that engages the enucleated lens capsule to provide a post-phaco biomimetic complex that mimics the energy-absorbing and energy-releasing characteristics of an accommodative lens capsule. An adaptive lens element is coupled to the annular peripheral body portion. In this embodiment, the peripheral capsular shaping portion of the implant body carries at least one fluid-filled interior chamber that communicates with a central chamber in the adaptive lens element that actuates a deformable surface thereof. The flexing of the peripheral body portion in response to zonular tensioning and de-tensioning provides an adaptive optic mechanism wherein fluid media flows between the respective chambers to deform the lens surface to increase or decrease lens power. For example, in one embodiment, the peripheral body portion carries a posterior negative power lens that can be altered in power during accommodation to cooperate with a second lens element to provide variable focus.
  • [0018]
    Accordingly, a principal advantage of the present invention is the provision of deformable, rollable intraocular devices such as capsular shaping devices that utilize shape memory alloy forms, such shaping devices enabling an artificial lens system to provide accommodative amplitude (diopters of power modification).
  • [0019]
    The invention advantageously provides a capsular shaping element with integrated optics that require only a very small entry incision for implantation—for example a sub-1 mm. minimal incision through the cornea.
  • [0020]
    The invention advantageously provides an independent module comprising a capsular shaping structure of a thin film material that conforms to and maintains an intracapsular volume for receiving an IOL.
  • [0021]
    The invention provides a capsular shaping structure of a superelastic shape memory alloy form within a shape memory polymer envelope that conforms to and maintains an intracapsular volume.
  • [0022]
    The invention advantageously provides an independent module comprising a capsular shaping structure that can cooperate with drop-in fixed focus IOL or a drop-in accommodating IOL.
  • [0023]
    The invention advantageously provides an independent module comprising a capsular shaping element that allows for simplified lens exchange.
  • [0024]
    The invention provides an independent module comprising a capsular shaping structure that is adapted to cooperate with, and amplify, zonular tensioning and de-tensioning caused by ciliary muscle relaxation and contraction to enable various types of an accommodating lens systems.
  • [0025]
    The invention advantageously provides a modular capsular shaping element that is adapted to cooperate with both (i) vitreous displacement caused by ciliary muscle contraction; and (ii) zonular tensioning and de-tensioning caused by ciliary muscle relaxation and contraction, to amplify lens translation in a novel types of accommodating lens systems.
  • [0026]
    The invention provides an IOL with optic or non-optic body portions that carry a photomodifiable SMP that can be irradiated to adjust an operational parameter of an adaptive optic or accommodating lens system.
  • [0027]
    The invention provides an IOL with a polymer non-optic body portion that carries an anti-fibrotic pharmacological agent for release about the capsular sac for preventing or limiting fibrosis and shrinkage of the capsular sac.
  • [0028]
    These and other objects of the present invention will become readily apparent upon further review of the following drawings and specification.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0029]
    In order to better understand the invention and to see how it may be carried out in practice, some preferred embodiments are next described, by way of non-limiting examples only, with reference to the accompanying drawings, in which like reference characters denote corresponding features consistently throughout similar embodiments in the attached drawings.
  • [0030]
    FIG. 1A is a perspective cut-away view of an eye with an opacified lens capsule.
  • [0031]
    FIG. 1B is a perspective cut-away view of the eye of FIG. 1A with a curvilinear capsularrhexis and the crystalline lens matrix removed by phacoemulsification, together with the implantation of a prior art 3-piece IOL.
  • [0032]
    FIG. 1C is a perspective cut-away view of the eye of FIG. 1B showing the lens capsule after wound healing wherein the lens capsule shrink-wraps around the prior art IOL.
  • [0033]
    FIG. 2 is a stress-strain graph of the thin-film superelastic nickel titanium alloy that is utilized in a preferred embodiments of the invention.
  • [0034]
    FIG. 3A is a schematic depiction of the crystalline lattice of the thin-film superelastic nickel titanium alloy of FIG. 2 in a martensite state.
  • [0035]
    FIG. 3B is a depiction of the crystalline lattice of the superelastic nickel titanium alloy of FIG. 3A in its memory austhenite state.
  • [0036]
    FIG. 4 is a perspective cut-away view of a lens capsule and Type “A” intraocular device corresponding to the invention comprising a deformable, rollable ultrathin capsular shaping element (CSE) of a thin-film expanse of shape memory material encased in a polymer.
  • [0037]
    FIG. 5 is a perspective cut-away view of the lens capsule of FIG. 4 that illustrates anterior and posterior engagement planes of the capsule that targeted for engagement by the Type “A” capsular shaping element (CSE) of FIG. 4.
  • [0038]
    FIG. 6 is a cut-away view of an alternative Type “A” capsular shaping element similar to that of FIG. 4 with a posterior annular body portion of a polymer.
  • [0039]
    FIG. 7 is a cut-away partial view of another alternative Type “A” capsular shaping element similar to that of FIGS. 4 and 6; this embodiment configured to provide additional stress-absorbing features and a non-elliptical equatorial region for allowing slight shrinkage of the lens capsule.
  • [0040]
    FIG. 8A is a schematic sectional view of a post-phaco lens capsule with its equatorial envelope after being shaped by the implant of FIG. 4 or FIG. 6.
  • [0041]
    FIG. 8B is a schematic sectional view of a post-phaco lens capsule with its equatorial envelope after being shaped by the implant of FIG. 7 wherein the equatorial region is non-elliptical after capsule shrinkage to reduce laxity in the zonular ligaments.
  • [0042]
    FIG. 9 is a cut-away view of an alternative Type “A” capsular shaping implant that comprises an elastic composite structure for creating enhanced stress-bearing capacity.
  • [0043]
    FIG. 10 is a cut-away view of an alternative Type “A” capsular shaping element that carries a biodegradable SMP or shape memory polymer for automatically altering the stress-bearing capacity of the implant following the wound healing response.
  • [0044]
    FIG. 11 is a cut-away view of another Type “A” capsular shaping element that carries an adjustable shape memory polymer (SMP) that responds to stimulus from a remote source for altering the stress-bearing capacity of the implant in the post-implant period.
  • [0045]
    FIG. 12 is a cut-away view of Type “A” composite capsular shaping body of a thin-film shape memory alloy and an outer polymer envelope.
  • [0046]
    FIGS. 13A-13B are sectional schematics of a Type “B” capsular shaping element with integrated optic element showing disaccommodative and accommodative positions, respectively.
  • [0047]
    FIG. 14 is a cut-away view of the Type “B” IOL of FIGS. 13A-13B.
  • [0048]
    FIGS. 15A-15B are sectional schematics of another Type “B” capsular shaping element with integrated fluid-filled adaptive optic element.
  • [0049]
    FIG. 15C is a view of another Type “B” capsular shaping body with and integrated gel-filled optic element that substantially occupies the volume of the capsular sac.
  • [0050]
    FIG. 16A is a sectional view of another Type “B” capsular shaping element with a posterior negative power adaptive lens element with fluid displacement means for altering the lens power.
  • [0051]
    FIG. 16B is a perspective view of the implant device of FIG. 16A.
  • [0052]
    FIG. 17 is a view of a Type “B” intraocular device of FIG. 16A showing a method of rolling the device for introduction into the eye, the body of a shape memory polymer (SMP) encasing a shape memory alloy form.
  • [0053]
    FIG. 18 is an exploded view of the two components of the device of FIG. 16A, showing flow channels between the interior chambers of the peripheral non-optic portion and the optic portion.
  • [0054]
    FIG. 19 is a sectional view of an alternative intraocular device similar to FIG. 16A showing a drop-in IOL in phantom view engaged with the implant device of FIG. 16A.
  • [0055]
    FIG. 20A is a sectional view of the intracapsular device of FIG. 16A at, or urged toward, its memory shape as when implanted in a capsular sac.
  • [0056]
    FIG. 20B is a sectional view of the intracapsular device of FIG. 20A deformed toward a temporary shape showing a flow of fluid from the peripheral non-optic portion to the optic portion to alter the power of the lens.
  • [0057]
    FIG. 21 is a sectional view of a capsular shaping body and adaptive bi-convex optic with communicating peripheral and central chamber portions showing accommodative and disaccommodative shapes.
  • [0058]
    FIG. 22 is a cut-away view of an alternative intraocular device similar to FIG. 16A illustrating a plurality of regions of a shape memory polymer adjacent to an interior space that are responsive to an external energy source to alter fluid flows and the dynamics of fluid displacement in the optic portion.
  • [0059]
    FIG. 23 is a perspective illustration of a capsular shaping system that utilizes first and second cooperating independent devices (in an accommodative shape), each similar to the device of FIG. 16A, one device for engaging the posterior capsule and a limited equatorial capsular region and the second device adapted for engaging only the anterior capsule and a limited equatorial region.
  • [0060]
    FIG. 24 is a perspective view of capsular shaping system of FIG. 23 with the cooperating independent devices in a disaccommodative shape.
  • [0061]
    FIG. 25 is a sectional view of an alternative intracapsular implant and adaptive optic with a shape memory polymer peripheral body that carries and interior fluid-filled chamber.
  • [0062]
    FIG. 26 is a sectional view of an alternative intracapsular implant and adaptive optic similar to that of FIG. 25 with alternative interior chamber locations.
  • [0063]
    FIG. 27 is a sectional view of an alternative intracapsular implant and adaptive optic similar to that of FIG. 26.
  • [0064]
    FIG. 28 is a sectional view of an alternative intracapsular implant with first and second adaptive optic elements that is similar to that of FIG. 25.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Principles of Superelasticity and Shape Memory in Classes of Ophthalmic Implant Materials
  • [0065]
    The capsular shaping element (CSE) of the invention is adapted for providing a biomimetic lens capsule complex that will enable an accommodative lens system, which can have several variants. The term biomimetic lens capsule is derived from the word biomimesis, which defines the development of structures that mimic life, or that imitate biological systems. In this case, the objective is to develop an implant that mimics the inherent elasticity of a young lens capsule for cooperating with the ciliary muscle to alter the shape or translation of an implanted optic element.
  • [0066]
    The biomimetic lens capsules corresponding to the invention are enabled by the phenomena of shape memory and superelasticity that are unique to certain newly developed so-called intelligent materials. In particular, one embodiment of CSE comprises a thin-film expanse of a nickel titanium alloy that is fabricated in a vacuum chamber deposition process. The nickel titanium form is embedded within a thin biocompatible polymer envelope. In the prior art, the principal uses of nickel titanium alloys have been developed from uniaxial models of superelasticity, such as in wires and other bulk materials. The invention extends the use of nickel titanium fabricated in thin film expanses. Additional embodiments comprise, at least in part, an expanse of a shape memory polymer (SMP), a shape memory polymer foam, or a bioerodible shape memory polymer.
  • [0067]
    In order to understand the invention, it is useful to describe the phenomena of shape memory and superelasticity that are unique to nickel titanium alloys, which are utilized in preferred embodiments of the capsular shaping structures of the invention. In an unstressed state, the nickel titanium alloy component will present itself in an austhenite phase—in which phase it exhibits linear elasticity. When stress is applied to the material, the austhenite phase transforms into a martensite phase that also exhibits linear elasticity, however, each phase has a different constant as can be seen in FIG. 2. The austhenite-martensite transformation produces a substantial level of strain (.sigma.) that is developed over a relatively small range of stress (.epsilon.). Upon unloading the stress, the transformation is reversible; however, the stress levels at which the reversible transformation occurs are smaller than the stresses that were require to produce the original austhenite-martensite transformation, as depicted in FIG. 2. Since, upon unloading, the material completely recovers it original shape, it is described as having elastic properties. In nickel titanium alloys, since the transformation strains are so large (greater that 6%) when compared to other alloys (typically on the order 0.1%), the material is defined as superelastic.
  • [0068]
    The superelastic properties of NiTi, and its strain-induced martensite transformation, can be understood by schematic illustrations of its crystalline lattice structure. The austhentite and martensite phases each define a very distinct crystalline structure or phases, as depicted in FIGS. 3A and 3B. Which phase is present depends on temperature and the amount of stress (consider it as internal pressure) being applied to the material. If a thin-film expanse of nickel titanium alloy is cooled from above its transformation temperature, it will remain 100% austenite until it reaches the martensite start temperature Ms for any particular amount of stress then being applied to the material. As depicted in FIG. 3A the sides of the martensite crystalline lattice marked a, b, and c are all different lengths. When pressure or stress (s) is applied to the lattice, these sides will change in length to compensate for the deformation forces. The angle marked .beta. also can change in response to such deforming forces. When the nickel titanium is elevated in temperature from below its crystallographic phase transition as shown in FIG. 3B, the material will recover its precise “memory” shape above its austenite start (As) temperature which can be designed to be slightly below body temperature (37° C.). In its austenite phase, the nickel titanium has only one possible crystalline orientation, which will be a pre-determined shape of the capsular shaping device. It is because of the wide variability of these lattice parameters that thin-film nickel titanium material can be easily deformed in its martensite phase. This accounts for the “rubbery” superelastic nature of NiTi that allows 6% or more recoverable elastic deformations.
  • [0069]
    The thin-film NiTi expanse of the invention can be fabricated as described in U.S. Pat. No. 5,061,914 to D. Busch and A. D. Johnson and the following published U.S. patent applications to A. D. Johnson et al.: No. 20020046783 A1 published Apr. 25, 2002; and No. 20010039449 A1 published Nov. 8, 2001. All of the patents and applications referred to in this paragraph are incorporated herein in their entirely by this reference.
  • [0070]
    The capsular shaping portion of the intracapsular implant corresponding to the invention also can be made in part, or in its entirety, from a class of shape memory polymer (SMP). The term “shape memory” is used in a different context when referring to SMPs. A shape memory polymer is said to demonstrate shape memory phenomena when it has a fixed temporary shape that can revert to a memory shape upon a selected stimulus, such as temperature. A shape memory polymer generally is characterized as defining phases that result from glass transition temperatures in segregated linear block co-polymers: a hard segment and a soft segment. The hard segment of SMP typically is crystalline with a defined melting point, and the soft segment is typically amorphous, with another defined transition temperature. In some embodiments, these characteristics may be reversed together with glass transition temperatures and melting points.
  • [0071]
    In one embodiment, when the SMP material is elevated in temperature above the melting point or glass transition temperature of the hard segment, the material then can be formed into a memory shape. The selected shape is memorized by cooling the SMP below the melting point or glass transition temperature of the hard segment. When the shaped SMP is cooled below the melting point or glass transition temperature of the soft segment while the shape is deformed, that (temporary) shape is fixed. The original shape is recovered by heating the material above the melting point or glass transition temperature of the soft segment but below the melting point or glass transition temperature of the hard segment. (Other methods for setting temporary and memory shapes are known which are described in the literature below). The recovery of the memory original shape is thus induced by an increase in temperature, and is termed the thermal shape memory effect of the polymer. The temperature can be at or below body temperature (37° C.) or a selected higher temperature.
  • [0072]
    Besides utilizing the thermal shape memory effect of the polymer, the memorized physical properties of the SMP can be controlled by its change in temperature or stress, particularly in ranges of the melting point or glass transition temperature of the soft segment of the polymer, e.g., the elastic modulus, hardness, flexibility, permeability and index of refraction. The scope of the invention of using SMPs in capsular shaping elements extends to the control of such physical properties, particularly in elastic composite structure described further below.
  • [0073]
    Examples of polymers that have been utilized in hard and soft segments of SMPs include polyurethanes, polynorborenes, styrene-butadiene co-polymers, cross-linked polyethylenes, cross-linked polycyclooctenes, polyethers, polyacrylates, polyamides, polysiloxanes, polyether amides, polyether esters, and urethane-butadiene co-polymers and others identified in the following patents and publications: U.S. Pat. No. 5,145,935 to Hayashi; U.S. Pat. No. 5,506,300 to Ward et al.; U.S. Pat. No. 5,665,822 to Bitler et al.; and U.S. Pat. No. 6,388,043 to Langer et al. (all of which are incorporated herein by reference); Mather, Strain Recovery in POSS Hybrid Thermoplastics, Polymer 2000, 41(1), 528; Mather et al., Shape Memory and Nanostructure in Poly(Norbonyl-POSS) Copolymers, Polym. Int. 49, 453-57 (2000); Lui et al., Thermomechanical Characterization of a Tailored Series of Shape Memory Polymers, J. App. Med. Plastics, Fall 2002; Gorden, Applications of Shape Memory Polyurethanes, Proceedings of the First International Conference on Shape Memory and Superelastic Technologies, SMST International Committee, pp. 115-19 (1994); Kim, et al., Polyurethanes having shape memory effect, Polymer 37(26):5781-93 (1996); Li et al., Crystallinity and morphology of segmented polyurethanes with different soft-segment length, J. Applied Polymer 62:631-38 (1996); Takahashi et al., Structure and properties of shape-memory polyurethane block copolymers, J. Applied Polymer Science 60:1061-69 (1996); Tobushi H., et al., Thermomechanical properties of shape memory polymers of polyurethane series and their applications, J. Physique IV (Colloque C1) 6:377-84 (1996)) (all of the cited literature incorporated herein by this reference).
  • [0074]
    The scope of the invention extends to the use of SMP foams for use in elastic composite structures, wherein the capsular shaping element utilizes the polymer foam together with an expanse of nickel titanium alloy. See Watt A. M., et al., Thermomechanical Properties of a Shape Memory Polymer Foam, available from Jet Propulsion Laboratories, 4800 Oak Grove Drive, Pasadena, Calif. 91109 (incorporated herein by reference). SMP foams function in a similar manner as the shape memory polymers described above. The scope of the invention also extends to the use of shape memory polymers that are sometimes called two-way shape memory polymers that can moved between two predetermined memory shapes in response to varied stimuli, as described in U.S. Pat. No. 6,388,043 to Langer et al. (incorporated herein by reference).
  • [0075]
    Other derivatives of SMPs within the scope of the invention fall into the class of bioerodible shape memory polymers that again may be used in certain elastic composite capsular shaping structures. As will be described below, one embodiment of capsular shaping element may be designed with composite portions that define a first modulus of elasticity for a period of time after implantation to resist force that may be applied by fibrosis during wound healing, followed by a second modulus of elasticity following biodegradation of a surface portion of the elastic composite structure.
  • [0076]
    In all variants of capsular shaping element that make use of expanses of thin films or composites of shape memory materials, the principal objectives relate to the design of an implant that will impart to the implant/lens capsule complex an unstressed more spherical shape with a lesser equatorial diameter when zonular tension is relaxed, and a stressed flatter shape with a greater equatorial diameter in response to zonular tensioning forces. The superelastic component will provide the ability to absorb known amounts of stress—and release the energy in a predetermined manner in millions of cycles over the lifetime of the implant in cooperation with an optic that will provide variable focus.
  • Exemplary Biomimetic Intracapsular Devices with Superelastic or Elastic Composite Components
  • [0077]
    A. Type “A” Implantable Intraocular Devices. FIG. 4 illustrates a cut-away view of an ultrathin flexible, deformable intraocular device (IOD) in the form of a capsular shaping element 100 corresponding to the present invention implanted in a capsular sac or bag 102. FIG. 5 illustrates a hypothetical capsular sac 102 that defines an anterior capsule 104A and a posterior capsule 104B after removal of the crystalline lens matrix LM. This disclosure will adopt the terminology commonly used by ophthalmologists that defines the anterior capsule as the portion of the capsular sac anterior to the capsular equator 108, and the posterior capsule as the sac portion posterior to the equatorial region. In FIG. 5, it can be seen that an anterior engagement plane A and a posterior engagement plane B comprise annular (inner) portions of the anterior and posterior capsules 104A and 104B that are substantially engaged by the capsular shaping element 100 of FIG. 4. The anterior plane A and posterior plane B are radially outward of a central optic zone indicated at C that ranges from about 4.5 to 7.0 mm in diameter. The anterior and posterior planes A and B are radially inward of an equatorial region indicated at E. In this disclosure, the term axis and its reference numeral 115 are applied to both the natural lens capsule and the capsular shaping element 100, and the term axis generally describes the optical axis of the vision system. The axial dimension AD refers to the dimension of the capsular implant or implant/lens capsule complex along axis 115.
  • [0078]
    In FIG. 4, the capsular shaping element 100 comprises a thin-film expanse 120 of a shape memory material, in this case a nickel titanium alloy, that is encased in a thin layer or coating of a biocompatible polymer 122. FIG. 4 thus shows the capsular shaping element 100 in a perspective view as it would appear in an unstressed state—similar to its appearance prior to its implantation—and maintaining the lens capsule in an open more spherical shape. The combination of the capsular shaping element 100 and the natural lens capsule, defined herein as the implant/lens capsule complex, is adapted to provide a biomimetic lens capsule that can cooperate with the eye's natural accommodation mechanisms to enable a new class of accommodating lens systems that mimic a naturally accommodative human lens capsule.
  • [0079]
    The IOD 100 of FIG. 4 defines a first anterior surface portion 105A that is adapted to engage the anterior plane A of the anterior capsule 104A of FIG. 5. The capsular shaping element 100 further defines a second posterior surface portion 105B that is adapted to engage the posterior plane B of the posterior capsule 104B of FIG. 5. The capsular shaping element 100 of FIG. 4 illustrates a device that has a discrete number of spaced apart peripheral arcuate extending body portions 112 a-112 n (where n indicates an integer) that are formed to extend from the anterior plane A of anterior capsule 104A to posterior plane B of posterior capsule 104B in a meridonal manner relative to axis 115. In FIG. 4, the peripheral extending portions 112 a-112 n transition to an anterior annular body portion indicated at 124 a. As will be described in another embodiment below, the annular body portion 124 a can be positioned anteriorly or posteriorly in the capsular sac. In the embodiment of FIG. 4, the posterior surface portion 105B comprises a plurality of regions of each arcuate peripheral body portion 112 a-112 n. It should be appreciated that the number of spaced apart arcuate peripheral portions 112 a-112 n can range from about 2 to 20, and moreover the wall portion 127 of the capsular shaping element 100 further can extend about the entire circumference of the IOD so that there would not be a plurality of discrete elements, particularly when an elastic composite is used as will be described below.
  • [0080]
    FIG. 6 shows an alternative embodiment wherein the capsular shaping structure 100 has other optional features and characteristics. First, the thin-film shape memory expanse 120 is insert-molded with a foldable posterior annular polymer portion 124 b to thereby provide a broader posterior surface portion 105B to engage plane B of the capsular sac. Further, the intracapsular implant defines an at least partly annular abrupt edge portion 126 (collectively) or projecting ridge for engaging the capsule interior to limit cell migration within the interface between the lens capsule and the implant. Preferably, such an annular edge 126 is provided both on the anterior and posterior surfaces of the implant 100. Third, the thin film shape-memory expanse 120 is shown with micro-machined fenestrations 128 which can be utilized to control localized stress-bearing capacities of the shape memory material. Both shaping elements 100 of FIGS. 4 and 6 can be rolled for introduction into the patient's eye.
  • [0081]
    Of particular interest, the capsular shaping element 100 of FIGS. 4 and 6 carries a thin film shape-memory alloy form 120 having a thickness of between about 5 microns and 50 microns. More preferably, the single layer of SMA 120 has a thickness between about 10 microns and 40 microns. The nickel titanium alloy form also is fabricated to define an Af (austhenite finish temperature) at less than about 37° C. To provide the thin film with the selected Af, the element is composed of between 45-55% each of titanium and nickel. As described above, the capsular shaping element 100 then will function is it superelastic condition to cooperate with the force of contraction of the human ciliary muscle and zonular tensioning (about 1 to 3 grams of force) about the equator of the capsular sac. In other words, the contracting forces of the ciliary muscle will be sufficient to deform the intraocular device 100 to provide the lens capsule complex with a lesser axial dimension—i.e., a flatter shape. Upon relaxation of the ciliary muscle and zonular tensioning about the equator of the capsular sac, the intraocular device 100 defines recoverable strain properties that returns the element to a less stressed state wherein the intraocular device has a greater axial dimension—i.e., a more spherical or globular shape.
  • [0082]
    The capsular shaping element 100 of FIGS. 4 and 6 corresponding to the invention also can be defined by its selected dimensions and its 3-D shape for engaging and supporting the interior of the capsular sac. The outer envelope dimensions of an accommodative lens capsule are about 3.0 to 5.5 mm. about the optical axis, with a diameter ranging from about 8.0 to 10.0 mm. Thus, the outer envelope of the capsular shaping element 100 as defined by its planform and molded memory shape (its unstressed state) would match the three dimensional shape of a young still-accommodative lens capsule. The thin-film SMA form together with the capsular sac (i.e., the implant/capsule complex) defines an axial dimension AD greater than about 3 mm. when not subject to zonular tensioning forces. Further, the thin-film expanse that comprises the capsular shaping element 100 has a selected thickness and planform that demonstrates stress/strain recovery at 37° C. in response to zonular tensioning forces that flattens the axial dimension AD to less than 3.0 mm. and preferably lessens the dimension AD by about 1.0 mm. to 2.5 mm. Upon release of zonular tensioning forces, the superelastic thin film expanse 120 will rapidly return the implant/capsule complex to its unstressed state and shape.
  • [0083]
    The capsular shaping element 100 (FIG. 4) further has a thickness and planform that demonstrates stress/strain recovery at 37° C. in response to zonular tensioning forces that allows stretching of the equatorial diameter of the implant/capsule complex by greater than about 10%. More preferably, the shape memory implant demonstrates stress/strain recovery at 37° C. in response to zonular tensioning forces that allows equatorial stretching by greater than about 15%.
  • [0084]
    The ciliary muscles CM, choroid and zonular fibers each have a modulus of elasticity, and the capsular shaping element 100 in combination with the capsular sac (i.e., implant/capsule complex) defines a lower modulus of elasticity than any of these tissues to insure they do not unnaturally deform during accommodation. A capsular shaping element 100 that carries a nickel titanium alloy form, in its superelastic state when at body temperature, is the optimal material for deforming in response to zonular tension by absorbing stress and thereafter releasing the absorbed energy to return the complex of the shaping element and lens capsule to its memory shape. In one embodiment corresponding to the invention, the intraocular device carries a seamless thin-film shape memory form that demonstrates a stress/strain recovery greater than 3% at 37° C. More preferably, the thin-film shape memory form demonstrates a stress/strain recovery greater than 5% at 37° C.
  • [0085]
    FIG. 7 illustrates, for convenience, a single peripheral arcuate body portion 112 a of an alternative embodiment of capsular shaping structure 140 and engagement planes A and B. All such peripheral body portions of the shaping element would have a similar shape and function as the single element of FIG. 7. In this variant, the element 140 has an additional “S”curve or bend portion 144 in the shape memory alloy that serves two purposes. First, the additional curve 144 together with the two radially outward curves 145 a and 145 b can develop greater elastic energy-absorbing and energy-releasing forces than the corresponding element 100 of FIG. 4. The embodiment in FIG. 7 places the superelastic structure more directly between planes A and B. This embodiment 140 provides greater strength that the lesser hoop strength of the device of FIGS. 4 and 6 wherein a single bend portion 145 is provided in the device that urges apart planes A and B.
  • [0086]
    The second advantage offered by the device 140 of FIG. 7 is that it will substantially engage the lens capsule 102 except for an equatorial band of the capsular sac. As can be seen in FIG. 7, the diameter 146 of the natural lens capsule is shown as it would be engaged and supported by the CSE as in FIG. 4 to provide a substantially elliptical or single radius equatorial region. As can be seen in FIGS. 7, 8A and 8B, the shaping element 140 of FIG. 7 defines a radially outward equatorial envelope that is substantially non-elliptical and without a radius that directly blends into the curvature of the anterior and posterior capsules. Thus, the shaping element 140 of FIG. 7 has a lesser maximum diameter 148 as indicated in FIGS. 8A-8B that will support the capsular sac in a lesser maximum diameter. It is believed that the shaping element 140 will thus support the capsular sac in an optimal open position—but allow the equatorial region of the capsule to shrink controllably after the evacuation of the crystalline lens matrix as occurs in the wound healing response and fibrotic response. This slight shrinkage of the capsular equator will then take any slack out of the zonular ligaments ZL which are believed to become lax due to lens growth over the lifetime of the patient. This will allow for more effective transfer of forces from the ciliary muscle CM to the shaping element 140 via the tightened equatorial region of the capsular sac 102.
  • [0087]
    FIG. 9 illustrates a portion of an alternative embodiment of capsular shaping device 150 corresponding to the invention that again is adapted to engage planes A and B (see FIG. 5) of a capsular sac 102. This embodiment differs in that the peripheral arcuate portions, or the entire expanse, comprises an elastic composite material (ECM) 152 that carries first and second thin-film NiTi expanses slightly spaced apart and molded into a substantially thick polymer portion indicated at 155. The first SMA form 158 a is similar to previous embodiments and the second layer of thin-film nickel titanium alloy is indicated at 158 b in FIG. 9. By assembling this composite structure, the implant can provide enhanced load-bearing and response capacities that, for example, may not be attained by a single thin-film NiTi form within an implant body.
  • [0088]
    FIG. 10 illustrates an exemplary part of an alternative embodiment of capsular shaping element 160 that is similar to previous variants that engage planes A and B (see FIG. 5) of a capsular sac 102. This embodiment differs in that the equatorial portion 162 of the shaping element that flexes in response to stresses applied by the ciliary muscle carries a biodegradable shape memory polymer 165 (or any biodegradable polymer known in the art). A preferred biodegradable polymer is a PHA (polyhydroxyalkanoate), or a co-polymer of a shape memory polymer and a PHA. The purpose of the biodegradable polymer portion 165 is to selectively alter the stress (load) bearing capacity of the equatorial portion 162 of the shaping element over time. It is believed that the initial wound healing response in the capsular sac following removal of the lens matrix will apply shrinkage or fibrotic forces that will lessen after the wound healing response is over. For this reason, the inventive capsular shaping element 160 can have a first greater load-bearing capacity for selected one week to month period after implantation. The capsular shaping element 160 then can define a lesser stress-bearing capacity after the biodegradable polymer 165 has degraded—with the lesser stress-bearing capacity being optimized for cooperating with tensioning forces applied by the ciliary muscle following wound healing.
  • [0089]
    FIG. 11 illustrates a portion of another alternative embodiment of capsular shaping element 180 that functions generally as the previous variants that engage planes A and B of a capsular sac 102. This embodiment differs in that the equatorial portion 182 of the shaping element that flexes in response to stresses applied by the ciliary muscle during accommodation carries an adjustable shape memory polymer 185. For example, the polymer can be a shape memory polymer that responds to stimuli from an external source to alter its modulus or shape between first and second memory shapes to selectively alter the stress (load) bearing capacity of the equatorial portion 182 of the shaping element at any time following its implantation. As described above, a shape memory polymer can be designed for photothermal modification at a selected level above body temperature to adjust modulus, flexibility, or permeability.
  • [0090]
    This aspect of the invention is shown in FIG. 11 wherein the external stimulus is light energy (e.g., a wavelength between 380 nm and 1800 nm, not limiting) that can alter the temperature or other parameter of the polymer to change its modulus or shape—which will alter the stress-bearing parameters of the composite. In the embodiment of FIG. 11, the adjustable shape memory polymer 185 is depicted as an exterior layer of the element 180 so that it is more easily exposed to a light beam 188. The light beam can be scanned and with an eye tracking system as is known in the art. The scope of the invention thus includes the use of an external energy source to modify the modulus, flexibility, permeability or other operational parameter of a non-optic portion of an intracapsular implant to optimize its resilient characteristics for enhancing the functionality of an accommodating lens system. It is believed that post-implant adjustability of such parameters will be critical for optimization of such accommodating lens systems. The modifiable polymer can be located in an region of the ophthalmic implant. The scope of the invention includes any form of stimulus, such as energy from a light source, electrical source or magnetic source.
  • [0091]
    FIG. 12 illustrates another embodiment of capsular shaping element 200 that is similar to the implant of FIG. 4. This version differs in that the polymer portion is shown as extending substantially in a complete expanse 210 that conforms to the inner surface of the capsular sac. Preferably, the expanse 210 is of a transparent material, and in one embodiment is any biocompatible urethane, silicon-urethane copolymer or another shape memory polymer described above. In this embodiment, the thin-film nickel titanium alloy 220 is insert molded into the polymer body portion to provide the stress-bearing capacity of the shaping element.
  • [0092]
    In all of the above described embodiments, the capsular shaping element and the remaining capsule sac is adapted to mimic a natural lens capsule in balancing its energy-absorbing and energy-releasing characteristics with the forces applied by the ciliary muscle. The capsular shaping element will thus prevent atrophy of the ciliary muscle and allow it to cooperate with, and adjust, the next optional component of the invention which is a cooperating independent IOL or an integrated optic element.
  • [0093]
    Still, it should be appreciated that the capsular shaping devices of FIGS. 4 to 11 comprise an important ophthalmic implant innovation. The capsular shaping devices will maintain the capsule as an open and viable structure, thus allowing the ophthalmologist to insert and replace any IOL as required to adjust the lens power over the lifetime of the patient. Explanting an in-the-sac IOL is not simple with current IOLs since the designs are intended to be shrink-wrapped in the capsule to maintain lens centration. In the future, it is likely that ultra-thin SMA haptics with thin optics will allow the development of replaceable IOLs that can be inserted and removed with a sub-1.0 mm. entry through the cornea making the IOL exchange an atraumatic procedure. It is believed that IOL replaceability will become a needed refractive option in clear lensectomy procedures to treat presbyopia, wherein over the lifetime of the patient a refractive lens change may be required due to refractive drift, or lens exchange for a new lens technology may be desired (e.g., for a wavefront corrected lens).
  • [0094]
    B. Type “B” Implantable Intraocular Devices. The Type “B” intraocular devices generally combine any of the Type “A” capsular shaping structures of the invention with an integrated optic portion to thereby provide an integrated accommodating IOL system. FIGS. 13A-13B and 14 illustrate a various views of a capsular shaping body 400 with shape memory alloy form 120 therein similar to that of FIG. 4 with an integrated optic element 410 coupled to the shaping element 400 by haptic portion 412. The haptic portions 412 (i) can be fixedly coupled to body 400, (ii) can be adapted to resiliently press outwardly to self-locate about the equator of the body 400, or (iii) can be adapted to cooperate with an engagement element in body 400 as shown in FIG. 19. FIGS. 13A-13B illustrate how changes in the shape of the CSE portion 400 are captured to cause the optic element 410 translate anteriorly lens to provide additional focusing power. Thus, the IOL system of FIG. 14 provides a substantially true accommodating lens system based on the mechanism of lens translation. In use, psuedo-accommodative vitreous displacement also would be enhanced by the implant that presents a substantially large convex body surface toward the vitreous, which would be an improvement over the reduced surface area of a shrink-wrapped posterior capsule. In this embodiment, the haptic portion 412 again is a superelastic NiTi form encased in a polymer that is further molded to transition to a central foldable lens as in known in the art.
  • [0095]
    FIGS. 15A-15B illustrate views of an alternative embodiment of integrated IOL 500A with a capsular shaping element portion 505 having NiTi form 120 therein together with an integrated optic portion 510 coupled to the shaping element 505 by an intermediate fixed coupling portion indicated at 502. In this embodiment, the optic portion 510 is a flexible fluid-filled optic with an anterior deformable surface layer 504A and an optional posterior deformable surface layer 504B that contains a displaceable fluid or gel media M therebetween. In such an adaptive optic embodiment, each surface 504A and 504B can comprise a lens element with the displaceable media having any index, or the surfaces 504A and 504B can contain an index-matched displaceable media M therebetween to effectively function as a single optic element. As can be seen in FIGS. 15A-15B, the change in shape of the capsular shaping portion 505 will alter the curvature of a deformable lens surface, or both surfaces, ac and pc to ac' and pc' while translating the optic anteriorly and increasing the thickness of the lens—all of which mimic a naturally accommodating lens to provide lens accommodation. FIG. 15C shows an alternative integrated IOL system 500B wherein the peripheral capsular shaping body 505 is as described previously with a SMA form therein to provide the capsular sac with the desired strain-absorbing properties. In this embodiment, the central optic portion 510 again is a flexible fluid-filled optic but with foldable (but non-adaptive) anterior and posterior lens elements 540 a and 540 b that contain a displaceable fluid or gel media M therebetween, either index matched or non-index matched. In the embodiment of FIG. 15C, the anterior and posterior lens elements 540 a and 540 b move apart during accommodation to increase lens power. In essence, this system emulates a natural lens capsule.
  • [0096]
    FIGS. 16A-16B are views of a Type “B” implant device 500C that has a capsular shaping body portion 505 together with a refined microfluidic system for causing fluid flows into a deformable adaptive optic portion 510 from a peripheral non-optic portion 512 that is adapted to engage the capsular sac. As can be seen in FIG. 16B, the capsular shaping body 505 has a plurality of peripheral arcuate extending elements 516 a-516 d that can number from about 3 to 12. Alternatively, the body portion 505 can extend 360.degree. about the implant, or a plurality of elements with an intermediate thin sheath element can extend 360.degree. about the implant. The implant defines an open anterior central region.
  • [0097]
    In the implant 500C of FIGS. 16A-16B, the peripheral capsular shaping portion 512 carries several features that can assist in causing a lens element or elements provide accommodative effects. The peripheral body portion 512 transitions to an annular body portion 526 that carries a posterior lens 520 with a deformable anterior surface 525 that can be controllably deformed by the flow of an index-matched fluid media M to and from an interior space or chamber indicated at 522B. The lens is deformed by flow from at least one peripheral chamber 522A in the peripheral elements 516 a-516 d. The fluid flows are designed to occur when elements 516 a-516 d are deformed from their memory shape (FIGS. 16A and 20A) to a temporary shape (FIG. 20B) by zonular tensioning. The memory shape of the body 505 again is provided by a superelastic NiTi form embedded therein (not shown). The peripheral body portion 512, as in all earlier embodiments, is adapted to deform under about 1.0 to 3.0 grams of applied force about the equatorial region of the implant.
  • [0098]
    In one embodiment as depicted in FIG. 16A, the lens 520 has a negative power and is adapted to cooperate with an independent positive power lens that is implanted in the open central portion of the capsular shaping body 505 as shown in phantom view in FIG. 19. It should be appreciated that the system of the invention can be designed for fluid flows to or from the central optic to add or subtract power to a positive power lens, a negative power lens or a piano lens.
  • [0099]
    FIG. 17 is a view of the intraocular device of FIGS. 16A-16B showing a method of rolling the device for introduction into the eye, wherein the body 505 is an assembly of a superelastic SMA form insert molded into a shape memory polymer, and the SMP then is compacted to a temporary shape. In such a preferred embodiment, a thin film NiTi form or a NiTi wire form together with the polymer component would be very thin. The peripheral body portion would be in the range of 25 to 100 microns in thickness, which is suitable for rolling or folding as shown in FIG. 17.
  • [0100]
    FIG. 18 is an exploded view of a manner of fabricating the implant 500C of FIGS. 16A-16B showing two components 532 a and 532 b de-mated with molded-in flow channels 540 that would communicate between the interior chambers of the optic portion and peripheral non-optic portion. In this embodiment, the deformable lens layer 525 is substantially thin while base portion 524 of the lens is less deformable or preferably non-deformable. The superelastic SMA form 120 (see FIG. 4) is molded into either or both polymer components 532 a and 532 b. A fluid media M is inserted into the chambers during or after bonding together the polymer components 532 a and 532 b.
  • [0101]
    FIG. 19 is a sectional view of an intraocular device 500C similar to that of FIG. 16A showing that the body 505 carries an engagement structure indicated at 560 for cooperating with and positioning the engagement ends 564 of haptics 565 that carries lens 580 (phantom view). FIG. 19 further shows how the optic 580 would translate to provide an accommodative effect as in the previous embodiment of FIGS. 13A-13B and 14.
  • [0102]
    Now turning to FIGS. 20A-20B, the movement of the peripheral capsular shaping body 512 from its memory shape to a temporary shape will cause compression of wall portion 528 a against wall portion 528 b to displace fluid media M from interior chambers 522A (collectively) to the interior space 522B in the lens 520 to alter it curvature to AC' from AC. The scope of the invention includes any of a variety of mechanisms and cavity shapes in the non-optic portion 512 that are compressed to cause fluid media flow to the optic portion. Also, the scope of the invention includes mechanisms and cavity shapes in the non-optic portion 512 that are expanded to cause fluid media flow from the optic portion. The interior space in the lens can be (i) centrally located or (ii) peripherally located in an annular region to thereby allow the deformation of the surface to add or subtract power in a plano lens, positive power lens or negative power lens. The peripheral extending portions 516 a-516 d carry NiTi forms either of a thin film expanse or wire forms to induce the portions 516 a-516 d toward the memory shape as well as return the chambers 522A to a “memory” volume. The sectional view of FIG. 16A illustrates the capsular sac and implant at, or urged toward, its memory shape as when implanted in a lens capsule LC (reference letter LC indicating the interior of the lens capsule). It can be seen that a substantial volume (first volume) of fluid media M is within the peripheral non-optic portion and chambers 522A therein. In this untensioned or memory state, there is a limited volume of media M in the interior space 522B of the lens.
  • [0103]
    In a disaccommodative state, referring to FIG. 20B, the sectional view shows the body portion 512 in a tensioned collapsed (temporary) shape when zonular tension flattens the lens capsule and collapses the axial dimension of the implant along optical axis 515. It can be seen that the axial collapse of implant causes compression of the peripheral chambers 522A and moves a volume of fluid media M into space 522B of the lens 520. The increased fluid pressure in the space 522B thereby deforms the lens surface 525 and subtracts from the negative power of the lens. It can be easily understood how this added fluid pressure can be used to reshape a lens to make a deformable surface, whether (i) to make the curvature steeper or flatter with a central interior space 522B or an annular interior space 522B; (ii) to add power or subtract power; or (iii) to move a piano element away from non-refractive parameters toward either a positive or negative power. It is important to note that the method of the invention includes providing a large fluid volume in the peripheral chambers 522A when compared to the lens chamber 522B to thereby provide hydraulic amplification means for transducing and amplifying the mechanical flexing of the body portion 512 to maximize lens deformation. FIG. 21 is a sectional view of an alternative adaptive optic device 500D wherein flexure of the peripheral portion 512 to a flatter shape impinges on the volume of the peripheral chamber portions 522A to subtract from the power of a bi-convex lens by adding an index-matched fluid media to the chamber portion 522B within the lens 520. It can be seen that the deformable surface 525 is restrained at the annular optic periphery by webs 580 to control the shape change in response to fluid media flow.
  • [0104]
    In any design of capsular shaping body or for an accommodating lens system, it may be necessary to provide post-fabrication adjustment means for (i) adjusting the flexibility and response to the peripheral body's deformation after implantation, (ii) the exact shape of a dimension of the implant to engage the lens capsule, (iii) the amplitude of accommodation, as well as (iv) providing for adjustment of lens optic parameters. To provide for such adjustments, FIG. 22 shows a cut-away view of a capsular shaping body and lens similar to the embodiment of FIG. 16A. A plurality of regions 588 of the capsular shaping body are of a shape memory polymer that is disposed adjacent to an interior space or chamber in the implant. Each SMP portion is responsive to an external energy source that cause it to swell to thereby impinge on the chamber to reduce its volume (increase internal fluid pressure). While the regions are discrete and spaced apart in FIG. 22, they also may be annular or comprise a thin layer of a polymer expanse. Similarly, the SMP regions (not shown) may extend within broad surface regions of the capsular shaping body to alter its modulus or flex characteristics. In particular, altering the mechanical properties of the polymer body component can offset and cooperate with the properties of the NiTi form 120 therein to alter the resilient characteristics of the composite.
  • [0105]
    FIGS. 23-24 illustrate a capsular shaping system with a first shaping body 500C similar to that of FIG. 16A together with a second independent inverted shaping device 600. The first device is adapted to engage the posterior capsule and a limited equatorial region (cf. FIG. 16A). The second device 600 is adapted for engaging only the anterior capsule and a limited equatorial region. The second shaping device 600 has a number of extending portions 616 a-616 d that cooperate with and are spaced between the corresponding portions of the first device 500B when implanted in a capsular sac. The second device 600 further defines an annular portion 605 that transitions into the extending portions 616 a-616 d. Of particular interest, the use of first and second independent shaping devices for engaging the anterior and posterior capsules with independently responsive elements allows the lens capsule to respond to zonular tensioning and de-tensioning more like a natural lens capsule. This can be understood by reference to equatorial indicator markings on the implants in FIGS. 23 and 24 which show the device in accommodative and non-accommodative shapes, respectively. It can be seen that the axial dimension of the capsular complex moves from AD to AD' as the system moves toward a disaccommodative shape (FIG. 24). It can easily be understood (see arrows) that movement of the capsule complex toward its non-accommodative equatorial dimension will cause the extending portions 516 a-516 d and extending portions 616 a-616 d to adjust or slip relative to the equatorial plane of the complex. In FIGS. 23 and 24, equatorial indicator markings X and Y on the respective extending portions 516 a-516 d and extending portions 616 a-616 d are shown in different alignments with one another when the lens capsule adjusts between accommodative and non-accommodative shapes. Of particular interest, the independent cooperating capsular shaping bodies will prevent the implant from simply forming a hinge at the equatorial apex of the device. By utilizing such a design feature, a greater amplitude of capsular shape change can be achieved for a given amplitude of zonular tensioning. It should be appreciated that the independent devices 500B and 600 can be coupled by thin flexible membranes (not shown) and fall within the scope of the invention, wherein the posterior and anterior shaping bodies still substantially provide the desirable functionality described above to prevent the hinge effect at the equatorial apex of the device.
  • [0106]
    The previous embodiments have illustrated peripheral body portions that are substantially thin and provided with an elastic response due to the superelastic SMA form 120 insert-molded therein. Embodiments of adaptive optic lens systems as described above are possible without, or with less reliance on, a superelastic shape memory alloy form in the implant. In order to provide a polymer peripheral body portion with suitable resilient characteristics for shaping the capsular sac and responding to zonular tensioning forces, a resilient gel-like shape memory polymer 745 can be used to define a memory shape that occupies a substantial peripheral portion of the capsular sac as in implant 700A of FIG. 25. Still, the shape memory polymer can be compacted to a temporary shape and rolled or folded as in FIG. 17. The fluid media M within the peripheral chamber(s) 722A and optic chamber 722B is non-compressible and accounts for the bulk of the implant that is introduced by an injector through the cornea into the capsular sac. FIG. 25 illustrates an implant device 700A that has a posterior lens that is adaptive in power by exchange of fluid media M between peripheral chamber 722A in peripheral portion 724 and central chamber 722B of lens 720 via channels 740. It can easily be seen from FIG. 25 that fluid can be selectively displaced from the periphery to the center when the respective volumes of the peripheral and central chamber portions are altered upon zonular tensioning and de-tensioning. The embodiment of FIG. 25 operates as the device of FIGS. 16A-16B with induced fluid flows adapted to deform the surface 725 of the adaptive lens 720.
  • [0107]
    FIGS. 26, 27 and 28 illustrate similar embodiments 700B, 700C and 700D that have peripheral chamber(s) 722A in various locations within the peripheral body for different strategies in collapsing the interior chamber(s) 722A therein to enable the adaptive optic. It can be understood that the interior chambers can be annular or spaced apart, or any combination thereof and be located in various portions of the implant periphery. The peripheral chambers can be in equatorial, posterior or anterior portions of the body periphery to alter the power of a single lens or two spaced apart lenses. The fluid flow channels to the lens are not shown for convenience.
  • [0108]
    Those skilled in the art will appreciate that the exemplary systems, combinations and descriptions are merely illustrative of the invention as a whole, and that variations in the dimensions and compositions of invention fall within the spirit and scope of the invention. Specific characteristics and features of the invention and its method are described in relation to some figures and not in others, and this is for convenience only. While the principles of the invention have been made clear in the exemplary descriptions and combinations, it will be obvious to those skilled in the art that modifications may be utilized in the practice of the invention, and otherwise, which are particularly adapted to specific environments and operative requirements without departing from the principles of the invention. The appended claims are intended to cover and embrace any and all such modifications, with the limits only of the true purview, spirit and scope of the invention.

Claims (15)

1. A method of providing an accommodative response to ciliary muscle movement in an eye, comprising:
an accommodating intraocular lens comprising an optic portion that refracts light;
rolling or folding the intraocular lens;
introducing the rolled or folded intraocular lens into the eye through a small incision in the eye; and
providing accommodation to the intraocular lens by allowing a refractive element of the optic portion to change curvature in response to ciliary muscle movement.
2. The method of claim 1 wherein allowing a refractive element of the optic portion to change curvature in response to ciliary muscle movement comprises allowing fluid to flow between a peripheral non-optic portion of the intraocular lens and the optic portion in response to ciliary muscle movement to change the curvature of the refractive element.
3. The method of claim 1 wherein allowing a refractive element of the optic portion to change curvature in response to ciliary muscle movement comprises allowing an anterior-most surface of the optic portion to change curvature in response to ciliary muscle contraction.
4. The method of claim 3 wherein allowing an anterior-most surface of the optic portion to change curvature in response to ciliary muscle movement comprises allowing a fluid to flow between a peripheral non-optic portion of the intraocular lens and a fluid chamber in the optic portion in response to ciliary muscle movement.
5. The method of claim 3 wherein allowing an anterior-most surface of the optic portion to change curvature in response to ciliary muscle movement comprises allowing the anterior-most surface of the optic portion to increase in curvature in response to ciliary muscle movement.
6. The method of claim 1 wherein introducing the rolled or folded intraocular lens into the eye comprises introducing the intraocular lens into a lens capsule.
7. The method of claim 6 wherein allowing a refractive element of the optic portion to change curvature in response to ciliary muscle movement comprises allowing the refractive element to change curvature in response to forces applied to a peripheral portion of the intraocular lens by the capsule in response to ciliary muscle movement.
8. An accommodating intraocular lens, comprising:
a deformable optic portion adapted to refract light, wherein the optic portion is adapted to be folded or rolled for insertion into an eye through a small incision,
wherein the optic portion comprises a refractive element adapted to change curvature in response to ciliary muscle movement to provide accommodation after unfolding or unrolling in the eye.
9. The accommodating intraocular lens of claim 8 further comprising a peripheral non-optic portion extending peripherally from the optic portion.
10. The accommodating intraocular lens of claim 9 wherein the peripheral non-optic portion is sized to fit within and engage with a lens capsule, and is further adapted to deform in response to ciliary muscle movement to change the curvature of the refractive element.
11. The accommodating intraocular lens of claim 8 further comprising a non-optic portion comprising a fluid chamber, wherein the optic portion comprises a fluid chamber in communication with the non-optic portion fluid chamber, and wherein the non-optic portion is adapted to respond to forces thereon to transfer fluid between the non-optic portion chamber and the optic portion chamber to change the curvature of the refractive element.
12. The accommodating intraocular lens of claim 11 wherein the non-optic portion comprises a plurality of haptics, wherein each of the haptics comprises a chamber in fluid communication with the fluid chamber in the optic portion.
13. The accommodating intraocular lens of claim 8 further comprises a non-optic peripheral portion extending from the optic portion, wherein the peripheral non-optic portion has a thickness along the optical axis greater than a thickness of the optic portion along the optical axis.
14. The accommodating intraocular lens of claim 13, wherein the non-optic peripheral portion comprises a plurality of discrete haptics, and wherein each of the plurality of discrete haptics has a thickness along the optical axis that is greater than the thickness along the optical axis of the optic portion.
15. The accommodating intraocular lens of claim 13 wherein the non-optic peripheral portion is sized to fit within a lens capsule.
US12782644 2002-02-02 2010-05-18 Accommodating Intraocular Lens Abandoned US20100228344A1 (en)

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US40801902 true 2002-09-03 2002-09-03
US43111002 true 2002-12-04 2002-12-04
US10358038 US8048155B2 (en) 2002-02-02 2003-02-03 Intraocular implant devices
US12782644 US20100228344A1 (en) 2002-02-02 2010-05-18 Accommodating Intraocular Lens

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US12782644 US20100228344A1 (en) 2002-02-02 2010-05-18 Accommodating Intraocular Lens
US13300245 US8425599B2 (en) 2002-02-02 2011-11-18 Accommodating intraocular lenses and methods of use
US14278249 US9456895B2 (en) 2002-02-02 2014-05-15 Accommodating intraocular lens
US15284350 US20170020662A1 (en) 2002-02-02 2016-10-03 Accommodating intraocular lenses

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US13300245 Active US8425599B2 (en) 2002-02-02 2011-11-18 Accommodating intraocular lenses and methods of use
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Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090027661A1 (en) * 2007-07-23 2009-01-29 Steven Choi Systems and Methods for Testing Intraocular Lenses
US8048155B2 (en) * 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
US8158712B2 (en) 2007-02-21 2012-04-17 Powervision, Inc. Polymeric materials suitable for ophthalmic devices and methods of manufacture
US8361145B2 (en) 2002-12-12 2013-01-29 Powervision, Inc. Accommodating intraocular lens system having circumferential haptic support and method
US8447086B2 (en) 2009-08-31 2013-05-21 Powervision, Inc. Lens capsule size estimation
US8454688B2 (en) 2002-12-12 2013-06-04 Powervision, Inc. Accommodating intraocular lens having peripherally actuated deflectable surface and method
WO2012067994A3 (en) * 2010-11-15 2013-11-21 Elenza, Inc. Adaptive intraocular lens
US8668734B2 (en) 2010-07-09 2014-03-11 Powervision, Inc. Intraocular lens delivery devices and methods of use
US20140172089A1 (en) * 2012-12-17 2014-06-19 Novartis Ag Capsule Expander Devices, Systems, and Methods for Inhibiting Capsular Opacification and Stabilizing the Capsule
US8900298B2 (en) 2010-02-23 2014-12-02 Powervision, Inc. Fluid for accommodating intraocular lenses
US8968396B2 (en) 2007-07-23 2015-03-03 Powervision, Inc. Intraocular lens delivery systems and methods of use
US8992609B2 (en) 2001-08-31 2015-03-31 Powervision, Inc. Intraocular lens system and method for power adjustment
US20150142106A1 (en) * 2012-02-22 2015-05-21 Omega Ophthalmics Llc Prosthetic capsular bag and method of inserting the same
US9186244B2 (en) 2012-12-21 2015-11-17 Lensgen, Inc. Accommodating intraocular lens
US9220590B2 (en) 2010-06-10 2015-12-29 Z Lens, Llc Accommodative intraocular lens and method of improving accommodation
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9277987B2 (en) 2002-12-12 2016-03-08 Powervision, Inc. Accommodating intraocular lenses
US9364318B2 (en) 2012-05-10 2016-06-14 Z Lens, Llc Accommodative-disaccommodative intraocular lens
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
US9504558B2 (en) 2015-02-10 2016-11-29 Omega Ophthalmics Llc Attachable optic prosthetic capsular devices
US9610155B2 (en) 2008-07-23 2017-04-04 Powervision, Inc. Intraocular lens loading systems and methods of use
US9642699B2 (en) 2014-06-19 2017-05-09 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
US9872763B2 (en) 2004-10-22 2018-01-23 Powervision, Inc. Accommodating intraocular lenses

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060238702A1 (en) 1999-04-30 2006-10-26 Advanced Medical Optics, Inc. Ophthalmic lens combinations
US20030060881A1 (en) 1999-04-30 2003-03-27 Advanced Medical Optics, Inc. Intraocular lens combinations
EP1363562A2 (en) * 2001-02-20 2003-11-26 Nun Yehoshua Ben Intraocular lens
EP1420722B1 (en) 2001-08-21 2010-12-01 Nulens Ltd Accommodating lens assembly
US7150759B2 (en) * 2002-01-14 2006-12-19 Advanced Medical Optics, Inc. Multi-mechanistic accommodating intraocular lenses
US7763069B2 (en) 2002-01-14 2010-07-27 Abbott Medical Optics Inc. Accommodating intraocular lens with outer support structure
US20070100445A1 (en) * 2003-02-03 2007-05-03 Shadduck John H Intraocular lenses and business methods
US6966649B2 (en) * 2002-08-12 2005-11-22 John H Shadduck Adaptive optic lens system and method of use
US7160324B2 (en) * 2002-05-17 2007-01-09 Amo Groningen, B.V. Method in eye surgery
US7125422B2 (en) * 2002-10-25 2006-10-24 Quest Vision Technology, Inc. Accommodating intraocular lens implant
US20040082993A1 (en) 2002-10-25 2004-04-29 Randall Woods Capsular intraocular lens implant having a refractive liquid therein
US7662180B2 (en) 2002-12-05 2010-02-16 Abbott Medical Optics Inc. Accommodating intraocular lens and method of manufacture thereof
US7247168B2 (en) * 2002-12-12 2007-07-24 Powervision, Inc. Accommodating intraocular lens system and method
US7261737B2 (en) * 2002-12-12 2007-08-28 Powervision, Inc. Accommodating intraocular lens system and method
JP4480585B2 (en) * 2002-12-12 2010-06-16 パワービジョン, インコーポレイテッド Regulation and methods of the intraocular lens
CA2517576A1 (en) 2003-03-06 2004-09-23 John H. Shadduck Adaptive optic lens and method of making
US7044461B2 (en) * 2003-04-30 2006-05-16 The Regents Of The University Of California Method and apparatus for adjustably induced biaxial strain
US20050107873A1 (en) * 2003-11-18 2005-05-19 Medennium, Inc. Accommodative intraocular lens and method of implantation
US20050131535A1 (en) 2003-12-15 2005-06-16 Randall Woods Intraocular lens implant having posterior bendable optic
CN101642392A (en) * 2004-04-29 2010-02-10 纽镜有限公司 Accommodating intraocular lens assemblies and accommodation measurement implant
US20050267321A1 (en) * 2004-06-01 2005-12-01 Shadduck John H Elastomeric magnetic nanocomposite biomedical devices
US7806930B2 (en) * 2004-08-27 2010-10-05 Brown David C Device for attachment to a capsule in an eye
CA2580142A1 (en) * 2004-10-13 2006-04-20 Nulens Ltd Accommodating intraocular lens (aiol), and aiol assemblies including same
CN101203192B (en) * 2005-03-30 2010-09-15 纽镜有限公司 Adjustable intraocular lens assembly and separation element
US20080228186A1 (en) 2005-04-01 2008-09-18 The Regents Of The University Of Colorado Graft Fixation Device
US20060241752A1 (en) * 2005-04-20 2006-10-26 Israel Henry M Accommodating multiple lens assembly
US7591849B2 (en) * 2005-07-01 2009-09-22 Bausch & Lomb Incorpoted Multi-component accommodative intraocular lens with compressible haptic
WO2007019389A1 (en) * 2005-08-05 2007-02-15 Visiogen, Inc. Accommodating diffractive intraocular lens
US20070032868A1 (en) * 2005-08-08 2007-02-08 Randall Woods Capsular shape-restoring device
US8034107B2 (en) * 2005-09-01 2011-10-11 Stenger Donald C Accommodating intraocular lens
EP1770302A1 (en) * 2005-09-30 2007-04-04 Acandis GmbH & Co. KG Damping method and device
US9636213B2 (en) * 2005-09-30 2017-05-02 Abbott Medical Optics Inc. Deformable intraocular lenses and lens systems
US20070118216A1 (en) * 2005-11-21 2007-05-24 Joel Pynson Accommodative intraocular lens
US20070168027A1 (en) * 2006-01-13 2007-07-19 Brady Daniel G Accommodating diffractive intraocular lens
US8377125B2 (en) * 2006-04-05 2013-02-19 Anew Optics, Inc. Intraocular lens with accommodation
WO2008023379A3 (en) * 2006-08-25 2008-04-17 Nulens Ltd Intraocular lens implantation kit
CA2673388C (en) 2006-12-22 2015-11-24 Amo Groningen B.V. Accommodating intraocular lens, lens system and frame therefor
US7713299B2 (en) * 2006-12-29 2010-05-11 Abbott Medical Optics Inc. Haptic for accommodating intraocular lens
CA2674018C (en) 2006-12-29 2015-05-26 Advanced Medical Optics, Inc. Multifocal accommodating intraocular lens
US20080161914A1 (en) 2006-12-29 2008-07-03 Advanced Medical Optics, Inc. Pre-stressed haptic for accommodating intraocular lens
US20080161912A1 (en) * 2007-01-02 2008-07-03 Alcon, Inc. Intraocular Lens
US8273123B2 (en) * 2007-03-05 2012-09-25 Nulens Ltd. Unitary accommodating intraocular lenses (AIOLs) and discrete base members for use therewith
USD702346S1 (en) 2007-03-05 2014-04-08 Nulens Ltd. Haptic end plate for use in an intraocular assembly
KR100807939B1 (en) * 2007-03-08 2008-02-28 박경진 Lens assembly
KR100843454B1 (en) * 2007-03-08 2008-07-03 박경진 Supporter for intraocular lens
US20090228101A1 (en) 2007-07-05 2009-09-10 Visiogen, Inc. Intraocular lens with post-implantation adjustment capabilities
WO2009015240A3 (en) * 2007-07-23 2009-06-25 Powervision Inc Lens delivery system
US8480734B2 (en) * 2007-12-27 2013-07-09 Anew Optics, Inc. Intraocular lens with accommodation
US8034108B2 (en) 2008-03-28 2011-10-11 Abbott Medical Optics Inc. Intraocular lens having a haptic that includes a cap
JP5276165B2 (en) * 2008-07-24 2013-08-28 ニューレンズ・リミテッド Adjustable intraocular lens (AIOL) Capsule
CN102186438A (en) * 2008-10-15 2011-09-14 爱尔康公司 Accommodating intraocular lens
US20110313522A1 (en) * 2008-11-26 2011-12-22 Anew Optics, Inc. Pseudophakic Accommodating Intraocular Lens
EP2361060A4 (en) * 2008-11-26 2014-02-26 Anew Optics Inc Haptic devices for intraocular lens
US20100179653A1 (en) * 2009-01-09 2010-07-15 Claudio Argento Intraocular Lenses and Methods of Accounting for Capsule Size Variability and Post-Implant Changes in the Eye
US20130131794A1 (en) * 2009-01-09 2013-05-23 Terah Whiting Smiley Accommodating Intraocular Lenses and Methods of Use
WO2010091420A1 (en) * 2009-02-09 2010-08-12 Whitsett Jeffrey C Exchangeable intraocular lens device and method of use
WO2010102121A1 (en) * 2009-03-04 2010-09-10 Anew Optics, Inc. Injector for intraocular lens
EP2445446A2 (en) 2009-06-26 2012-05-02 Abbott Medical Optics Inc. Accommodating intraocular lenses
EP2461768A1 (en) 2009-08-03 2012-06-13 Abbott Medical Optics Inc. Intraocular lens for providing accomodative vision
KR101304014B1 (en) 2009-08-13 2013-09-04 아큐포커스, 인크. Corneal inlay with nutrient transport structures
WO2011020078A1 (en) 2009-08-13 2011-02-17 Acufocus, Inc. Masked intraocular implants and lenses
CA2800217C (en) * 2010-05-21 2015-05-26 Anew Optics, Inc. Pseudophakic accommodating intraocular lens
WO2012106673A1 (en) * 2011-02-04 2012-08-09 Forsight Labs, Llc Intraocular accommodating lens
US9427493B2 (en) 2011-03-07 2016-08-30 The Regents Of The University Of Colorado Shape memory polymer intraocular lenses
CN105726166B (en) * 2011-03-07 2017-10-27 科罗拉多州立大学董事会 IOL shape memory polymer
US9186243B2 (en) * 2011-05-31 2015-11-17 Novartis Ag Accommodative intraocular lens and method of implantation
US8608800B2 (en) * 2011-08-02 2013-12-17 Valdemar Portney Switchable diffractive accommodating lens
NL2009596C (en) * 2011-10-11 2014-09-04 Akkolens Int Bv Accommodating intraocular lens with combination of base plates.
WO2013082545A1 (en) 2011-12-02 2013-06-06 Acufocus, Inc. Ocular mask having selective spectral transmission
WO2013086644A1 (en) * 2011-12-12 2013-06-20 Kleger Markus Surgical capsule tensioning ring for ophthalmology
US8574295B2 (en) 2012-01-17 2013-11-05 Vista Ocular, Llc Accommodating intra-ocular lens system
EP2825130B1 (en) 2012-03-12 2017-05-10 Doci Innovations GmbH Intra-ocular lens having helical haptics of shape memory materials
DE102012016893A1 (en) * 2012-08-24 2014-05-15 Be Innovative Gmbh Intraocular lens, particularly Kapselsackintraokularlinse
DE102012016892A1 (en) * 2012-08-24 2014-02-27 Be Innovative Gmbh Intraocular lens, particularly Ziliarintraokularlinse
WO2014047345A1 (en) * 2012-09-19 2014-03-27 Roger Zaldivar Improved intraocular lens and method
US9510939B2 (en) * 2012-10-08 2016-12-06 Valdemar Portney Multi-mode operating optic for presbyopia correction
US9622855B2 (en) * 2012-10-08 2017-04-18 Valdemar Portney Remote multifocal to monofocal optic conversion
US9486311B2 (en) 2013-02-14 2016-11-08 Shifamed Holdings, Llc Hydrophilic AIOL with bonding
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
US20160310263A1 (en) * 2013-12-13 2016-10-27 Frontier Vision Co., Ltd. Accommodating intraocular lens
CN106456830A (en) 2014-04-18 2017-02-22 宾视研发公司 (meth)acrylamide polymers for contact lens and intraocular lens
KR101718074B1 (en) * 2015-03-25 2017-03-20 주식회사 로섹 Intraocular lens supporter
WO2016185017A1 (en) * 2015-05-21 2016-11-24 Marco Feusi Capsule tensioning ring
WO2017030582A1 (en) * 2015-08-19 2017-02-23 Cherne Scott A Intraocular lens holder
US20170049560A1 (en) * 2015-08-21 2017-02-23 Scott A. Cherne Intraocular Lens Holder
US9681945B2 (en) 2015-09-15 2017-06-20 Mohsen Shahinpoor Double accommodating intraocular accordion lens

Citations (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180687B2 (en) *
US3552860A (en) * 1968-06-07 1971-01-05 Aga Ab Refraction measuring apparatus
US4253199A (en) * 1978-09-25 1981-03-03 Surgical Design Corporation Surgical method and apparatus for implants for the eye
US4254509A (en) * 1979-04-09 1981-03-10 Tennant Jerald L Accommodating intraocular implant
US4373218A (en) * 1980-11-17 1983-02-15 Schachar Ronald A Variable power intraocular lens and method of implanting into the posterior chamber
US4423809A (en) * 1982-02-05 1984-01-03 Staar Surgical Company, Inc. Packaging system for intraocular lens structures
US4435856A (en) * 1982-04-14 1984-03-13 Esperance Francis A L Bifocal intraocular lens structure and spectacle actuation frame
US4490860A (en) * 1982-01-18 1985-01-01 Ioptex Inc. Intraocular lens apparatus and method for implantation of same
US4494254A (en) * 1982-05-03 1985-01-22 Osvaldo Lopez Intraocular lens
US4512040A (en) * 1982-06-09 1985-04-23 Mcclure Hubert L Bifocal intraocular lens
US4575373A (en) * 1984-11-02 1986-03-11 Johnson Don R Laser adjustable intraocular lens and method of altering lens power
US4585457A (en) * 1985-05-16 1986-04-29 Kalb Irvin M Inflatable intraocular lens
US4720286A (en) * 1984-07-20 1988-01-19 Bailey Kelvin E Multifocus intraocular lens
US4731080A (en) * 1985-01-18 1988-03-15 Galin Miles A Coated intraocular lens
US4731078A (en) * 1985-08-21 1988-03-15 Kingston Technologies Limited Partnership Intraocular lens
US4731079A (en) * 1986-11-26 1988-03-15 Kingston Technologies, Inc. Intraocular lenses
US4813956A (en) * 1987-04-03 1989-03-21 Ioptex Research, Inc. Method of forming single-piece intraocular lens and core member and lens formed thereby
US4816031A (en) * 1988-01-29 1989-03-28 Pfoff David S Intraocular lens system
US4892543A (en) * 1989-02-02 1990-01-09 Turley Dana F Intraocular lens providing accomodation
US4902293A (en) * 1989-04-13 1990-02-20 Feaster Fred T Intraocular lens with inflatable haptic
US4919151A (en) * 1987-07-06 1990-04-24 California Institute Of Technology Synthetic polymer for endocapsular lens replacement
US4994082A (en) * 1988-09-09 1991-02-19 Ophthalmic Ventures Limited Partnership Accommodating intraocular lens
US4995880A (en) * 1989-09-26 1991-02-26 Galib Samuel H Intraocular lens and method of surgically implanting same in an eye
US4995879A (en) * 1989-10-10 1991-02-26 Dougherty Robert R Intraocular lens with unitary drawn haptics
US5015254A (en) * 1989-08-18 1991-05-14 Adatomed Pharmazeutische Und Medizintechnische Gesellschaft Mbh Intraocular posterior chamber lens
US5078740A (en) * 1990-04-02 1992-01-07 Walman Gerald B Intraocular lens
US5200430A (en) * 1991-03-21 1993-04-06 Escalon Ophthalmics, Inc. Debridement of bodily cavities using debridement fluids
US5201763A (en) * 1992-02-28 1993-04-13 Allergan, Inc. Thin intraocular lens
US5213579A (en) * 1990-12-25 1993-05-25 Menicon Co, Ltd. Intraocular lens having balloon member and tube filled with gel
US5275624A (en) * 1991-04-04 1994-01-04 Menicon Co., Ltd. Device for inhibiting aftercataract
US5275623A (en) * 1991-11-18 1994-01-04 Faezeh Sarfarazi Elliptical accommodative intraocular lens for small incision surgery
US5288293A (en) * 1992-09-24 1994-02-22 Donnell Jr Francis E O In vivo modification of refractive power of an intraocular lens implant
US5290892A (en) * 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5391590A (en) * 1993-01-12 1995-02-21 Allergan, Inc. Injectable intraocular lens compositions and precursors thereof
US5405386A (en) * 1993-07-09 1995-04-11 Kabi Pharmacia Ophthalmics, Inc. Intraocular lens with improved cylindrical haptic
US5489302A (en) * 1994-05-24 1996-02-06 Skottun; Bernt C. Accommodating intraocular lens
US5496366A (en) * 1990-04-27 1996-03-05 Cumming; J. Stuart Accommodating intraocular lens
US5506300A (en) * 1985-01-04 1996-04-09 Thoratec Laboratories Corporation Compositions that soften at predetermined temperatures and the method of making same
US5512609A (en) * 1992-04-14 1996-04-30 Allergan, Inc. Reinforced compositions and lens bodies made from same
US5593436A (en) * 1993-05-12 1997-01-14 Langerman; David W. Capsular bag implants with dual 360 ring structures for inhibiting posterior capsular opacification
US5607472A (en) * 1995-05-09 1997-03-04 Emory University Intraocular lens for restoring accommodation and allows adjustment of optical power
US5628795A (en) * 1995-03-15 1997-05-13 Langerman David W Spare parts for use in ophthalmic surgical procedures
US5633504A (en) * 1995-03-30 1997-05-27 Wesley-Jessen Corporation Inspection of optical components
US5891931A (en) * 1997-08-07 1999-04-06 Alcon Laboratories, Inc. Method of preparing foldable high refractive index acrylic ophthalmic device materials
US6013101A (en) * 1994-11-21 2000-01-11 Acuity (Israel) Limited Accommodating intraocular lens implant
US6015842A (en) * 1997-08-07 2000-01-18 Alcon Laboratories, Inc. Method of preparing foldable hydrophilic ophthalmic device materials
US6176878B1 (en) * 1998-12-17 2001-01-23 Allergan Sales, Inc. Accommodating intraocular lens
US6180687B1 (en) * 1996-04-08 2001-01-30 Alcon Laboratories, Inc. In vivo polymerizable ophthalmic compositions and methods of using
US6188526B1 (en) * 1998-06-26 2001-02-13 Denso Corporation Variable focus lens device having temperature fluctuation compensating feature for lens device liquid
US6190410B1 (en) * 1999-04-29 2001-02-20 Bausch & Lomb Surgical, Inc. Intraocular lenses
US6195807B1 (en) * 1999-08-06 2001-03-06 Terry Chou Curved lens combination for swimming/diving goggles
US6197059B1 (en) * 1990-04-27 2001-03-06 Medevec Licensing, B.V. Accomodating intraocular lens
US6217612B1 (en) * 1999-09-10 2001-04-17 Randall Woods Intraocular lens implant having eye accommodating capabilities
US6342073B1 (en) * 1999-12-30 2002-01-29 J. Stuart Cumming Intraocular lens for posterior vaulting
US6348437B1 (en) * 1996-05-01 2002-02-19 Dow Corning Corporation Silicone oils with improved viscosity stability
US20020046783A1 (en) * 2000-07-10 2002-04-25 Johnson A. David Free standing shape memory alloy thin film and method of fabrication
US20030003295A1 (en) * 2000-11-27 2003-01-02 Dreher Andreas W. Apparatus and method of correcting higher-order aberrations of the human eye
US20030004569A1 (en) * 2000-02-03 2003-01-02 Haefliger Eduard Anton Lens implant
US6503276B2 (en) * 1998-11-10 2003-01-07 Advanced Medical Optics Accommodating multifocal intraocular lens
US20030018384A1 (en) * 2001-07-17 2003-01-23 Medennium, Inc. Accommodative intraocular lens
US6517577B1 (en) * 1998-05-28 2003-02-11 Thinoptx, Inc. Crossed haptics for intraocular lenses
US20030042176A1 (en) * 1997-11-04 2003-03-06 Andrew Alderson Separation method and apparatus incorporating materials having a negative poisson ratio
US20030050696A1 (en) * 1999-08-09 2003-03-13 Cumming J. Stuart Lens for increased depth of focus
US20030050695A1 (en) * 2001-09-07 2003-03-13 Lin Chwen Yih Intraocular lens that may accommodate automatically
US20030060881A1 (en) * 1999-04-30 2003-03-27 Advanced Medical Optics, Inc. Intraocular lens combinations
US20030060878A1 (en) * 2001-08-31 2003-03-27 Shadduck John H. Intraocular lens system and method for power adjustment
US6551354B1 (en) * 2000-03-09 2003-04-22 Advanced Medical Optics, Inc. Accommodating intraocular lens
US20030078658A1 (en) * 2001-01-25 2003-04-24 Gholam-Reza Zadno-Azizi Single-piece accomodating intraocular lens system
US20030078656A1 (en) * 2001-01-25 2003-04-24 Nguyen Tuan Anh Accommodating intraocular lens system with separation member
US6554859B1 (en) * 2000-05-03 2003-04-29 Advanced Medical Optics, Inc. Accommodating, reduced ADD power multifocal intraocular lenses
US20040001180A1 (en) * 2002-07-01 2004-01-01 Saul Epstein Variable focus lens with internal refractive surface
US20040006386A1 (en) * 2002-06-28 2004-01-08 Valint Paul L. Surface modification of functional group-containing intraocular lenses
US20040006387A1 (en) * 2002-07-03 2004-01-08 Kelman Charles David Intraocular lens
US20040008419A1 (en) * 1995-05-12 2004-01-15 Schachar Ronald A. Variable focus lens by small changes of the equatorial lens diameter
US20040015236A1 (en) * 1991-11-18 2004-01-22 Sarfarazi Faezeh M. Sarfarazi elliptical accommodative intraocular lens for small incision surgery
US6692525B2 (en) * 1992-02-28 2004-02-17 Advanced Medical Optics, Inc. Intraocular lens
US6695881B2 (en) * 2002-04-29 2004-02-24 Alcon, Inc. Accommodative intraocular lens
US20040039446A1 (en) * 2002-08-26 2004-02-26 Advanced Medical Optics, Inc. Accommodating intraocular lens assembly with multi-functional capsular bag ring
US20040054408A1 (en) * 2002-09-13 2004-03-18 Advanced Medical Optics, Inc. Accommodating intraocular lens assembly with aspheric optic design
US6709108B2 (en) * 2001-08-31 2004-03-23 Adaptive Optics Associates, Inc. Ophthalmic instrument with adaptive optic subsystem that measures aberrations (including higher order aberrations) of a human eye and that provides a view of compensation of such aberrations to the human eye
US20040059343A1 (en) * 2002-09-25 2004-03-25 Kevin Shearer Novel enhanced system for intraocular lens insertion
US6712848B1 (en) * 1992-09-30 2004-03-30 Staar Surgical Company, Inc. Deformable intraocular lens injecting apparatus with transverse hinged lens cartridge
US20040082993A1 (en) * 2002-10-25 2004-04-29 Randall Woods Capsular intraocular lens implant having a refractive liquid therein
US20040082994A1 (en) * 2002-10-25 2004-04-29 Randall Woods Accommodating intraocular lens implant
US20050021139A1 (en) * 2003-02-03 2005-01-27 Shadduck John H. Ophthalmic devices, methods of use and methods of fabrication
US6860601B2 (en) * 2002-02-06 2005-03-01 John H. Shadduck Adaptive optic lens system and method of use
US6878320B1 (en) * 1999-03-06 2005-04-12 The University Of Bolton, Higher Education Corporation A Uk Corporation Auxetic materials
US6884261B2 (en) * 2001-01-25 2005-04-26 Visiogen, Inc. Method of preparing an intraocular lens for implantation
US7001374B2 (en) * 2000-03-21 2006-02-21 Minu, L.L.C. Adjustable inlay with multizone polymerization
US20060069433A1 (en) * 2001-02-20 2006-03-30 Nulens, Ltd., Intraocular lens
US20070088433A1 (en) * 2005-10-17 2007-04-19 Powervision Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use
US20080015689A1 (en) * 2002-12-12 2008-01-17 Victor Esch Accommodating Intraocular Lens System and Method
US20080046075A1 (en) * 2002-12-12 2008-02-21 Esch Victor C Accommodating Intraocular Lens System and Method
US20080046074A1 (en) * 2002-12-12 2008-02-21 Smith David J Accommodating Intraocular Lens System Having Spherical Aberration Compensation and Method
US20090005865A1 (en) * 2002-02-02 2009-01-01 Smiley Terry W Post-Implant Accommodating Lens Modification
US20090030425A1 (en) * 2007-07-23 2009-01-29 Terah Whiting Smiley Lens Delivery System
US20090027661A1 (en) * 2007-07-23 2009-01-29 Steven Choi Systems and Methods for Testing Intraocular Lenses
US7485144B2 (en) * 2002-12-12 2009-02-03 Powervision, Inc. Methods of adjusting the power of an intraocular lens
US7494505B2 (en) * 2002-07-26 2009-02-24 Advanced Medical Optics, Inc. Method and device for manipulation of an intraocular lens
US8048155B2 (en) * 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
US8162927B2 (en) * 2000-03-21 2012-04-24 Gholam A. Peyman Method and apparatus for accommodating intraocular lens

Family Cites Families (177)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US100982A (en) * 1870-03-22 Orlando clarke
US42176A (en) * 1864-04-05 Retarding blooming of fruit-trees
US4304895A (en) 1973-06-20 1981-12-08 Wesley-Jessen, Inc. Ultraviolet absorbing corneal contact lenses
US4055602A (en) 1976-01-08 1977-10-25 The Upjohn Company 2-Decarboxy-2-hydroxy-methyl-5-oxa-17-phenyl-18,19,20-trinor-PGF-analogs
US4251887A (en) 1979-04-02 1981-02-24 Anis Aziz Y Posterior chamber capsular lens implant and method for implantation of the lens
US4435855A (en) 1980-04-01 1984-03-13 Pannu Jaswant S Universal intraocular lens and a method of measuring an eye chamber size
US4409691A (en) 1981-11-02 1983-10-18 Levy Chauncey F Focussable intraocular lens
US5776191A (en) 1982-02-05 1998-07-07 Staar Surgical Company Fixation system for intraocular lens structures
US4466705A (en) 1982-09-30 1984-08-21 Michelson Paul E Fluid lens
US4528311A (en) 1983-07-11 1985-07-09 Iolab Corporation Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles
US4604295A (en) 1983-12-22 1986-08-05 Loctite Corporation Visible light absorbing peroxy-esters
US4615701A (en) * 1984-01-03 1986-10-07 Woods Randall L Intraocular lens and method of implantation thereof
US4784485A (en) 1984-11-29 1988-11-15 Unisearch Limited Contact lens zonometer
US5235003A (en) 1985-01-04 1993-08-10 Thoratec Laboratories Corporation Polysiloxane-polylactone block copolymers
US4620954A (en) 1985-06-07 1986-11-04 Ciba Vision Care Corp. Hydrogel from ultraviolet-initiated copolymerization
US4787903A (en) 1985-07-24 1988-11-29 Grendahl Dennis T Intraocular lens
JPH0632906B2 (en) 1985-10-18 1994-05-02 富士写真フイルム株式会社 Polishing tape for polishing a magnetic head
US4685921A (en) 1986-02-24 1987-08-11 Peyman Gholam A Variable refractive power, expandable intraocular lenses
US4693717A (en) 1986-03-12 1987-09-15 Michelson Paul E Intraocular lens formed in situ within the eye
US4685922A (en) 1986-06-25 1987-08-11 Peyman Gholam A Alterable refractive power intraocular lenses
GB2196857B (en) 1986-10-31 1990-09-05 Medinvent Sa A device for transluminal implantation
US4950289A (en) 1986-11-03 1990-08-21 Coopervision, Inc. Small incision intraocular lens with adjustable refractive power
US5145884A (en) 1986-11-13 1992-09-08 Menicon Co., Ltd. Ultraviolet-hardenable adhesive
US4842601A (en) 1987-05-18 1989-06-27 Smith S Gregory Accommodating intraocular lens and method of implanting and using same
US4790847A (en) 1987-05-26 1988-12-13 Woods Randall L Intraocular lens implant having eye focusing capabilities
US4913536A (en) 1987-07-14 1990-04-03 Daniel Barnea Variable power lens and method
US4888012A (en) 1988-01-14 1989-12-19 Gerald Horn Intraocular lens assemblies
DE68920167D1 (en) 1988-02-12 1995-02-09 Menicon Co Ltd A method of manufacturing a balloon for an intraocular lens.
US4836201A (en) 1988-03-24 1989-06-06 Patton Medical Technologies, Inc. "Envelope" apparatus for inserting intra-ocular lens into the eye
US4963148A (en) 1988-04-11 1990-10-16 Ceskoslvnska Akademie Ved Intraocular optical system
US4932966A (en) * 1988-08-15 1990-06-12 Storz Instrument Company Accommodating intraocular lens
JP2502132B2 (en) 1988-09-30 1996-05-29 三菱重工業株式会社 Shape memory polyurethane elastomer - shaped body
US4946469A (en) 1989-04-20 1990-08-07 Faezeh Sarfarazi Intraocular lens
RU1810052C (en) 1989-06-15 1993-04-23 Киевский институт усовершенствования врачей Artificial crystalline lens
JPH0744938Y2 (en) 1989-06-22 1995-10-11 三菱電機株式会社 Refrigerator door magnet gasket
US5061914A (en) 1989-06-27 1991-10-29 Tini Alloy Company Shape-memory alloy micro-actuator
DE3927667A1 (en) 1989-08-22 1991-02-28 Espe Stiftung Use of photopolymerizable extent than introkularlinsen filler eye diseases in combating cataract and other
US5047051A (en) 1990-04-27 1991-09-10 Cumming J Stuart Intraocular lens with haptic anchor plate
US5171266A (en) 1990-09-04 1992-12-15 Wiley Robert G Variable power intraocular lens with astigmatism correction
US5066301A (en) 1990-10-09 1991-11-19 Wiley Robert G Variable focus lens
US5203788A (en) 1991-03-14 1993-04-20 Wiley Robert G Micromotor actuated adjustable focus lens
US5152789A (en) 1991-05-14 1992-10-06 Allergan, Inc. Fixation member for an intraocular lens
US5326347A (en) 1991-08-12 1994-07-05 Cumming J Stuart Intraocular implants
US5665822A (en) 1991-10-07 1997-09-09 Landec Corporation Thermoplastic Elastomers
US5578081A (en) 1991-11-12 1996-11-26 Henry H. McDonald Eye muscle responsive artificial lens unit
US6423094B1 (en) 1991-11-18 2002-07-23 Faezeh M. Sarfarazi Accommodative lens formed from sheet material
FR2685498B1 (en) * 1991-12-23 1994-12-30 Corning Inc An optical proximity coupling between two waveguides integrated congestion and reduced optical component integrated by application.
US5444106A (en) 1992-04-21 1995-08-22 Kabi Pharmacia Ophthalmics, Inc. High refractive index silicone compositions
US5251993A (en) 1992-08-25 1993-10-12 Sigourney James W Connecting structure
US5443506A (en) * 1992-11-18 1995-08-22 Garabet; Antoine L. Lens with variable optical properties
US5444135A (en) 1992-12-17 1995-08-22 Exxon Chemical Patents Inc. Direct synthesis by living cationic polymerization of nitrogen-containing polymers
US5676669A (en) 1993-04-30 1997-10-14 Colvard; Michael Intraocular capsular shield
US5423929A (en) 1993-10-27 1995-06-13 Allergan, Inc. Intraocular lenses and methods for producing same
WO1995021594A1 (en) 1994-02-09 1995-08-17 Kabi Pharmacia Ophthalmics, Inc. Rapid implantation of shape transformable optical lenses
WO1995028897A3 (en) 1994-04-19 1995-11-30 Henry H Mcdonald Lens insertable between the iris and the natural lens
US5585049A (en) 1994-09-02 1996-12-17 Allergan Method for forming fixation members after optic attachment
US5697973A (en) 1994-09-19 1997-12-16 Peyman; Gholam A. Intraocular silicone lens
EP1627613B8 (en) 1995-02-15 2008-09-03 The Nice Trust, a Trust of the Isle of Man Accommodating intraocular lens having T-shaped haptics
WO1996040303A1 (en) 1995-06-07 1996-12-19 Alcon Laboratories, Inc. Improved high refractive index ophthalmic lens materials
JP3363003B2 (en) * 1995-10-03 2003-01-07 株式会社日立製作所 An optical transmission system using an optical amplifier and an optical amplifier
US6322589B1 (en) * 1995-10-06 2001-11-27 J. Stuart Cumming Intraocular lenses with fixated haptics
US5984962A (en) 1996-01-22 1999-11-16 Quantum Vision, Inc. Adjustable intraocular lens
US5728155A (en) 1996-01-22 1998-03-17 Quantum Solutions, Inc. Adjustable intraocular lens
US5800533A (en) * 1996-03-18 1998-09-01 Harry C. Eggleston Adjustable intraocular lens implant with magnetic adjustment facilities
CN1196787A (en) 1996-05-08 1998-10-21 桑坦德·塞贝尔·罗伯托 New liquid modulated lens for condensing solar energy
US5774273A (en) 1996-08-23 1998-06-30 Vari-Lite, Inc. Variable-geometry liquid-filled lens apparatus and method for controlling the energy distribution of a light beam
JPH10206609A (en) 1997-01-21 1998-08-07 M L C:Kk Optical device or lens therefor
US5928282A (en) 1997-06-13 1999-07-27 Bausch & Lomb Surgical, Inc. Intraocular lens
JPH1147168A (en) * 1997-07-16 1999-02-23 Henry M Israel The intraocular lens assembly
US5989462A (en) 1997-07-31 1999-11-23 Q2100, Inc. Method and composition for producing ultraviolent blocking lenses
JP3641110B2 (en) 1997-08-20 2005-04-20 株式会社メニコン Material for a soft intraocular lens
US5843188A (en) 1997-10-20 1998-12-01 Henry H. McDonald Accommodative lens implantation
KR100438477B1 (en) 1997-12-02 2004-07-03 호야 헬쓰케어 가부시키가이샤 Intraocular lenses and process for producing molded-in type intraocular lenses
JP3297685B2 (en) 1997-12-12 2002-07-02 ホーヤ・ヘルスケア株式会社 Soft intraocular lens
RU2215542C2 (en) 1998-02-23 2003-11-10 Массачусетс Инститьют Оф Текнолоджи Biodecomposing polymers able recovery of form
CA2316945A1 (en) 1998-02-23 1999-08-26 Mnemoscience Gmbh Shape memory polymers
EP1250162B1 (en) 1998-03-16 2004-09-15 Pharmacia Groningen B.V. Materials suitable for intraocular lens production
JPH11276509A (en) * 1998-03-27 1999-10-12 ▲桜▼井精技株式会社 Structure of intraocular lens and method for adjusting focal distance
US6552860B1 (en) 1998-05-01 2003-04-22 Ray M. Alden Variable Fresnel type structures and process
FR2778093B1 (en) 1998-05-04 2000-06-16 Khalil Hanna IOL
JPH11332903A (en) 1998-05-28 1999-12-07 Menicon Co Ltd Jig for intraocular lens inspection
US5926248A (en) 1998-06-26 1999-07-20 Bausch & Lomb, Incorporated Sunglass lens laminate
CA2343159C (en) 1998-09-15 2010-06-22 Novartis Ag Perfluoropolyalkylpolyether polymers for ophthalmic applications
FR2784575B1 (en) 1998-10-15 2000-12-22 Megaoptic Gmbh Accommodative intraocular implant
EP1128761B1 (en) 1998-11-13 2003-04-09 K. Th. Prof. Dr. Bende A method and an apparatus for the simultaneous determination of surface topometry and biometry of the eye
US6117171A (en) 1998-12-23 2000-09-12 Skottun; Bernt Christian Encapsulated accommodating intraocular lens
US6450642B1 (en) 1999-01-12 2002-09-17 California Institute Of Technology Lenses capable of post-fabrication power modification
DE19904441C1 (en) 1999-02-01 2000-09-07 Preusner Paul Rolf accommodative intraocular lens
US6488708B2 (en) 1999-04-09 2002-12-03 Faezeh Sarfarazi Open chamber, elliptical, accommodative intraocular lens system
US7662179B2 (en) 1999-04-09 2010-02-16 Sarfarazi Faezeh M Haptics for accommodative intraocular lens system
US6309585B1 (en) 1999-04-23 2001-10-30 Rodenstock North America, Inc. Curable casting compositions having a high refractive index and high impact resistance
US6406494B1 (en) 1999-04-30 2002-06-18 Allergan Sales, Inc. Moveable intraocular lens
US6616692B1 (en) 1999-04-30 2003-09-09 Advanced Medical Optics, Inc. Intraocular lens combinations
US6685741B2 (en) 1999-07-29 2004-02-03 Bausch & Lomb Incorporated Intraocular lenses
EP1210380B1 (en) 1999-09-07 2005-03-16 Alcon Inc. Foldable ophthalmic and otorhinolaryngological device materials
US6299641B1 (en) * 1999-09-10 2001-10-09 Randall Woods Intraocular lens implant having eye accommodating capabilities
US6599317B1 (en) 1999-09-17 2003-07-29 Advanced Medical Optics, Inc. Intraocular lens with a translational zone
US6645246B1 (en) * 1999-09-17 2003-11-11 Advanced Medical Optics, Inc. Intraocular lens with surrounded lens zone
FR2799952B1 (en) * 1999-10-21 2001-12-14 Humanoptics Ag IOL
DE50013494D1 (en) 1999-12-14 2006-11-02 Boehm Hans Georg Fokussierfähige intraocular lens
US6586740B1 (en) 1999-12-15 2003-07-01 Bausch & Lomb Incorporated Method and apparatus for detecting lenses in package
WO2001053559A1 (en) * 2000-01-24 2001-07-26 Smart Therapeutics, Inc. Thin-film shape memory alloy device and method
US7455407B2 (en) 2000-02-11 2008-11-25 Amo Wavefront Sciences, Llc System and method of measuring and mapping three dimensional structures
FR2804860B1 (en) 2000-02-16 2002-04-12 Humanoptics Ag Implant cristallinien accomodatif
US6797004B1 (en) * 2000-03-02 2004-09-28 Advanced Medical Optics, Inc. Holders for intraocular lenses
JP2001252300A (en) 2000-03-14 2001-09-18 Mototsugu Nishinobu Method for replacing crystalline lens substance
JP3677240B2 (en) 2000-03-20 2005-07-27 カリフォルニア インスティテュート オブ テクノロジー Application of wavefront sensor to capable magnification adjusted after manufacture lenses
US20120226351A1 (en) 2000-03-21 2012-09-06 Peyman Gholam A Accommodating intraocular lens
US20050113911A1 (en) 2002-10-17 2005-05-26 Peyman Gholam A. Adjustable intraocular lens for insertion into the capsular bag
US6436092B1 (en) 2000-03-21 2002-08-20 Gholam A. Peyman Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith
US6609793B2 (en) 2000-05-23 2003-08-26 Pharmacia Groningen Bv Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations
JP2003534048A (en) 2000-05-24 2003-11-18 フアルマシア・フローニンゲン・ベー・ベー Preselection method polymerizable fluid which forms an intraocular lens
US6730123B1 (en) 2000-06-22 2004-05-04 Proteus Vision, Llc Adjustable intraocular lens
US6660035B1 (en) * 2000-08-02 2003-12-09 Advanced Medical Optics, Inc. Accommodating intraocular lens with suspension structure
US7060094B2 (en) * 2000-08-07 2006-06-13 Ophthalmotronics, Inc. Accommodating zonular mini-bridge implants
US6610350B2 (en) 2000-10-05 2003-08-26 Menicon Co., Ltd. Method of modifying ophthalmic lens surface by plasma generated at atmospheric pressure
US6592621B1 (en) 2000-11-10 2003-07-15 Rudolph S. Domino Flexible intra-ocular lens of variable focus
US6558420B2 (en) 2000-12-12 2003-05-06 Bausch & Lomb Incorporated Durable flexible attachment components for accommodating intraocular lens
JP3735346B2 (en) 2000-12-22 2006-01-18 フアルマシア・フローニンゲン・ベー・ベー Method for obtaining an ophthalmic lens to reduce the eye aberrations
US6464725B2 (en) 2001-01-23 2002-10-15 Bernt Christian Skotton Two-lens adjustable intraocular lens system
US20030078657A1 (en) 2001-01-25 2003-04-24 Gholam-Reza Zadno-Azizi Materials for use in accommodating intraocular lens system
US6786934B2 (en) 2001-01-25 2004-09-07 Visiogen, Inc. Biasing element for intraocular lens system
US6818158B2 (en) 2001-01-25 2004-11-16 Visiogen, Inc. Accommodating intraocular lens system and method of making same
US6827738B2 (en) 2001-01-30 2004-12-07 Timothy R. Willis Refractive intraocular implant lens and method
EP1368868A4 (en) * 2001-03-02 2005-01-19 Corning Inc Barium fluoride high repetition rate uv excimer laser
WO2002071976A3 (en) 2001-03-13 2003-03-13 Sarver & Associates Adjustable intraocular lens
US6596025B2 (en) 2001-03-15 2003-07-22 Valdemar Portney Narrow profile intraocular lens
US6638305B2 (en) * 2001-05-15 2003-10-28 Advanced Medical Optics, Inc. Monofocal intraocular lens convertible to multifocal intraocular lens
US6524340B2 (en) * 2001-05-23 2003-02-25 Henry M. Israel Accommodating intraocular lens assembly
US6638304B2 (en) 2001-07-20 2003-10-28 Massachusetts Eye & Ear Infirmary Vision prosthesis
EP1420722B1 (en) 2001-08-21 2010-12-01 Nulens Ltd Accommodating lens assembly
US6443985B1 (en) * 2001-08-27 2002-09-03 Randall Woods Intraocular lens implant having eye accommodating capabilities
US6656223B2 (en) 2001-08-30 2003-12-02 Advanced Medical Optics, Inc. Foldable intraocular lenses with highly flexible optics and rigid fixation members
ES2636974T3 (en) 2001-10-12 2017-10-10 Becton, Dickinson And Company Basket apparatus type for the transport of biological samples
GB0126234D0 (en) 2001-11-01 2002-01-02 Khoury Elie Intraocular lens implant having accommodative capabilities
JP2003144387A (en) 2001-11-09 2003-05-20 Makoto Araya Method and device for displaying information on selection for intraocular lens
US7097660B2 (en) 2001-12-10 2006-08-29 Valdemar Portney Accommodating intraocular lens
FR2833154B1 (en) 2001-12-12 2004-11-19 Ioltechnologie Production Cassette and soft intraocular lens injector and injection process such lenses
US6743388B2 (en) 2001-12-31 2004-06-01 Advanced Cardiovascular Systems, Inc. Process of making polymer articles
US7326246B2 (en) 2002-01-14 2008-02-05 Advanced Medical Optics, Inc. Accommodating intraocular lens with elongated suspension structure
US7763069B2 (en) 2002-01-14 2010-07-27 Abbott Medical Optics Inc. Accommodating intraocular lens with outer support structure
US7150759B2 (en) 2002-01-14 2006-12-19 Advanced Medical Optics, Inc. Multi-mechanistic accommodating intraocular lenses
WO2003059208A3 (en) 2002-01-14 2004-05-13 Advanced Medical Optics Inc Accommodating intraocular lens with integral capsular bag ring
US20070100445A1 (en) 2003-02-03 2007-05-03 Shadduck John H Intraocular lenses and business methods
US6966649B2 (en) 2002-08-12 2005-11-22 John H Shadduck Adaptive optic lens system and method of use
US20030171808A1 (en) 2002-03-05 2003-09-11 Phillips Andrew F. Accommodating intraocular lens
US6846892B2 (en) 2002-03-11 2005-01-25 Johnson & Johnson Vision Care, Inc. Low polydispersity poly-HEMA compositions
US20030181749A1 (en) 2002-03-21 2003-09-25 Kunzler Jay F. Supercritical fluid extraction of vitreoretinal silicone tamponades
US20030187505A1 (en) 2002-03-29 2003-10-02 Xiugao Liao Accommodating intraocular lens with textured haptics
WO2004010904A1 (en) * 2002-07-29 2004-02-05 Yosef Gross Tensioning intraocular lens assembly
GB0217606D0 (en) 2002-07-30 2002-09-11 Rayner Intraocular Lenses Ltd Intraocular lens
JP4112944B2 (en) 2002-10-29 2008-07-02 株式会社ニデック Intraocular lens
US7370962B2 (en) 2002-10-31 2008-05-13 Johnson & Johnson Vision Care, Inc. Pupil regulated multifocal contact lenses
WO2004046768A3 (en) 2002-11-20 2004-08-12 Powervision Lens system and method for power adjustment
JP2006515189A (en) 2002-12-12 2006-05-25 パワービジョン,インコーポレイテッド Lens system for regulating power using micropump
US7662180B2 (en) 2002-12-05 2010-02-16 Abbott Medical Optics Inc. Accommodating intraocular lens and method of manufacture thereof
US20040111152A1 (en) 2002-12-10 2004-06-10 Kelman Charles David Accommodating multifocal intraocular lens
US7217288B2 (en) 2002-12-12 2007-05-15 Powervision, Inc. Accommodating intraocular lens having peripherally actuated deflectable surface and method
US8361145B2 (en) 2002-12-12 2013-01-29 Powervision, Inc. Accommodating intraocular lens system having circumferential haptic support and method
US9872763B2 (en) 2004-10-22 2018-01-23 Powervision, Inc. Accommodating intraocular lenses
US7074227B2 (en) 2002-12-12 2006-07-11 Valdemar Portney IOL insertion tool with forceps
US8328869B2 (en) 2002-12-12 2012-12-11 Powervision, Inc. Accommodating intraocular lenses and methods of use
US6616691B1 (en) 2003-01-10 2003-09-09 Alcon, Inc. Accommodative intraocular lens
CA2517576A1 (en) 2003-03-06 2004-09-23 John H. Shadduck Adaptive optic lens and method of making
JP4370371B2 (en) 2003-05-15 2009-11-25 学校法人昭和大学 Capsular bag holding device
US20050131535A1 (en) * 2003-12-15 2005-06-16 Randall Woods Intraocular lens implant having posterior bendable optic
US20050264756A1 (en) 2004-05-14 2005-12-01 Powervision, Inc. Custom contact lens molding system and methods
WO2008103798A3 (en) 2007-02-21 2009-09-11 Powervision, Inc. Polymeric materials suitable for ophthalmic devices and methods of manufacture
US20080306587A1 (en) 2007-02-21 2008-12-11 Jingjong Your Lens Material and Methods of Curing with UV Light
US8968396B2 (en) 2007-07-23 2015-03-03 Powervision, Inc. Intraocular lens delivery systems and methods of use
US20130131794A1 (en) 2009-01-09 2013-05-23 Terah Whiting Smiley Accommodating Intraocular Lenses and Methods of Use
US20100179653A1 (en) 2009-01-09 2010-07-15 Claudio Argento Intraocular Lenses and Methods of Accounting for Capsule Size Variability and Post-Implant Changes in the Eye
WO2011026068A3 (en) 2009-08-31 2011-07-14 Powervision, Inc. Lens capsule size estimation
JP2013520291A (en) 2010-02-23 2013-06-06 パワーヴィジョン・インコーポレーテッド Liquid for accommodative intraocular lens
WO2012006616A3 (en) 2010-07-09 2012-04-05 Powervision, Inc. Intraocular lens delivery devices and methods of use
EP2688515A4 (en) 2011-03-24 2015-04-15 Powervision Inc Intraocular lens loading systems and methods of use
EP2967842A4 (en) 2013-03-15 2016-12-07 Powervision Inc Intraocular lens storage and loading devices and methods of use

Patent Citations (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180687B2 (en) *
US3552860A (en) * 1968-06-07 1971-01-05 Aga Ab Refraction measuring apparatus
US4253199A (en) * 1978-09-25 1981-03-03 Surgical Design Corporation Surgical method and apparatus for implants for the eye
US4254509A (en) * 1979-04-09 1981-03-10 Tennant Jerald L Accommodating intraocular implant
US4373218A (en) * 1980-11-17 1983-02-15 Schachar Ronald A Variable power intraocular lens and method of implanting into the posterior chamber
US4490860A (en) * 1982-01-18 1985-01-01 Ioptex Inc. Intraocular lens apparatus and method for implantation of same
US4423809A (en) * 1982-02-05 1984-01-03 Staar Surgical Company, Inc. Packaging system for intraocular lens structures
US4435856A (en) * 1982-04-14 1984-03-13 Esperance Francis A L Bifocal intraocular lens structure and spectacle actuation frame
US4494254A (en) * 1982-05-03 1985-01-22 Osvaldo Lopez Intraocular lens
US4512040A (en) * 1982-06-09 1985-04-23 Mcclure Hubert L Bifocal intraocular lens
US4720286A (en) * 1984-07-20 1988-01-19 Bailey Kelvin E Multifocus intraocular lens
US4575373A (en) * 1984-11-02 1986-03-11 Johnson Don R Laser adjustable intraocular lens and method of altering lens power
US5506300A (en) * 1985-01-04 1996-04-09 Thoratec Laboratories Corporation Compositions that soften at predetermined temperatures and the method of making same
US4731080A (en) * 1985-01-18 1988-03-15 Galin Miles A Coated intraocular lens
US4585457A (en) * 1985-05-16 1986-04-29 Kalb Irvin M Inflatable intraocular lens
US4731078A (en) * 1985-08-21 1988-03-15 Kingston Technologies Limited Partnership Intraocular lens
US4731079A (en) * 1986-11-26 1988-03-15 Kingston Technologies, Inc. Intraocular lenses
US4813956A (en) * 1987-04-03 1989-03-21 Ioptex Research, Inc. Method of forming single-piece intraocular lens and core member and lens formed thereby
US4919151A (en) * 1987-07-06 1990-04-24 California Institute Of Technology Synthetic polymer for endocapsular lens replacement
US4816031A (en) * 1988-01-29 1989-03-28 Pfoff David S Intraocular lens system
US4994082A (en) * 1988-09-09 1991-02-19 Ophthalmic Ventures Limited Partnership Accommodating intraocular lens
US4892543A (en) * 1989-02-02 1990-01-09 Turley Dana F Intraocular lens providing accomodation
US4902293A (en) * 1989-04-13 1990-02-20 Feaster Fred T Intraocular lens with inflatable haptic
US5015254A (en) * 1989-08-18 1991-05-14 Adatomed Pharmazeutische Und Medizintechnische Gesellschaft Mbh Intraocular posterior chamber lens
US4995880A (en) * 1989-09-26 1991-02-26 Galib Samuel H Intraocular lens and method of surgically implanting same in an eye
US4995879A (en) * 1989-10-10 1991-02-26 Dougherty Robert R Intraocular lens with unitary drawn haptics
US5078740A (en) * 1990-04-02 1992-01-07 Walman Gerald B Intraocular lens
US5496366A (en) * 1990-04-27 1996-03-05 Cumming; J. Stuart Accommodating intraocular lens
US6197059B1 (en) * 1990-04-27 2001-03-06 Medevec Licensing, B.V. Accomodating intraocular lens
US5290892A (en) * 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5213579A (en) * 1990-12-25 1993-05-25 Menicon Co, Ltd. Intraocular lens having balloon member and tube filled with gel
US5200430A (en) * 1991-03-21 1993-04-06 Escalon Ophthalmics, Inc. Debridement of bodily cavities using debridement fluids
US5275624A (en) * 1991-04-04 1994-01-04 Menicon Co., Ltd. Device for inhibiting aftercataract
US5275623A (en) * 1991-11-18 1994-01-04 Faezeh Sarfarazi Elliptical accommodative intraocular lens for small incision surgery
US20040015236A1 (en) * 1991-11-18 2004-01-22 Sarfarazi Faezeh M. Sarfarazi elliptical accommodative intraocular lens for small incision surgery
US6692525B2 (en) * 1992-02-28 2004-02-17 Advanced Medical Optics, Inc. Intraocular lens
US5201763A (en) * 1992-02-28 1993-04-13 Allergan, Inc. Thin intraocular lens
US5512609A (en) * 1992-04-14 1996-04-30 Allergan, Inc. Reinforced compositions and lens bodies made from same
US5288293A (en) * 1992-09-24 1994-02-22 Donnell Jr Francis E O In vivo modification of refractive power of an intraocular lens implant
US6712848B1 (en) * 1992-09-30 2004-03-30 Staar Surgical Company, Inc. Deformable intraocular lens injecting apparatus with transverse hinged lens cartridge
US5391590A (en) * 1993-01-12 1995-02-21 Allergan, Inc. Injectable intraocular lens compositions and precursors thereof
US5593436A (en) * 1993-05-12 1997-01-14 Langerman; David W. Capsular bag implants with dual 360 ring structures for inhibiting posterior capsular opacification
US5405386A (en) * 1993-07-09 1995-04-11 Kabi Pharmacia Ophthalmics, Inc. Intraocular lens with improved cylindrical haptic
US5489302A (en) * 1994-05-24 1996-02-06 Skottun; Bernt C. Accommodating intraocular lens
US6013101A (en) * 1994-11-21 2000-01-11 Acuity (Israel) Limited Accommodating intraocular lens implant
US5628795A (en) * 1995-03-15 1997-05-13 Langerman David W Spare parts for use in ophthalmic surgical procedures
US5633504A (en) * 1995-03-30 1997-05-27 Wesley-Jessen Corporation Inspection of optical components
US5607472A (en) * 1995-05-09 1997-03-04 Emory University Intraocular lens for restoring accommodation and allows adjustment of optical power
US20040008419A1 (en) * 1995-05-12 2004-01-15 Schachar Ronald A. Variable focus lens by small changes of the equatorial lens diameter
US6180687B1 (en) * 1996-04-08 2001-01-30 Alcon Laboratories, Inc. In vivo polymerizable ophthalmic compositions and methods of using
US6348437B1 (en) * 1996-05-01 2002-02-19 Dow Corning Corporation Silicone oils with improved viscosity stability
US6015842A (en) * 1997-08-07 2000-01-18 Alcon Laboratories, Inc. Method of preparing foldable hydrophilic ophthalmic device materials
US5891931A (en) * 1997-08-07 1999-04-06 Alcon Laboratories, Inc. Method of preparing foldable high refractive index acrylic ophthalmic device materials
US20030042176A1 (en) * 1997-11-04 2003-03-06 Andrew Alderson Separation method and apparatus incorporating materials having a negative poisson ratio
US6517577B1 (en) * 1998-05-28 2003-02-11 Thinoptx, Inc. Crossed haptics for intraocular lenses
US6188526B1 (en) * 1998-06-26 2001-02-13 Denso Corporation Variable focus lens device having temperature fluctuation compensating feature for lens device liquid
US6503276B2 (en) * 1998-11-10 2003-01-07 Advanced Medical Optics Accommodating multifocal intraocular lens
US6176878B1 (en) * 1998-12-17 2001-01-23 Allergan Sales, Inc. Accommodating intraocular lens
US6878320B1 (en) * 1999-03-06 2005-04-12 The University Of Bolton, Higher Education Corporation A Uk Corporation Auxetic materials
US6190410B1 (en) * 1999-04-29 2001-02-20 Bausch & Lomb Surgical, Inc. Intraocular lenses
US20030060881A1 (en) * 1999-04-30 2003-03-27 Advanced Medical Optics, Inc. Intraocular lens combinations
US6195807B1 (en) * 1999-08-06 2001-03-06 Terry Chou Curved lens combination for swimming/diving goggles
US20030050696A1 (en) * 1999-08-09 2003-03-13 Cumming J. Stuart Lens for increased depth of focus
US6217612B1 (en) * 1999-09-10 2001-04-17 Randall Woods Intraocular lens implant having eye accommodating capabilities
US6342073B1 (en) * 1999-12-30 2002-01-29 J. Stuart Cumming Intraocular lens for posterior vaulting
US20030004569A1 (en) * 2000-02-03 2003-01-02 Haefliger Eduard Anton Lens implant
US6551354B1 (en) * 2000-03-09 2003-04-22 Advanced Medical Optics, Inc. Accommodating intraocular lens
US8162927B2 (en) * 2000-03-21 2012-04-24 Gholam A. Peyman Method and apparatus for accommodating intraocular lens
US7001374B2 (en) * 2000-03-21 2006-02-21 Minu, L.L.C. Adjustable inlay with multizone polymerization
US6554859B1 (en) * 2000-05-03 2003-04-29 Advanced Medical Optics, Inc. Accommodating, reduced ADD power multifocal intraocular lenses
US20020046783A1 (en) * 2000-07-10 2002-04-25 Johnson A. David Free standing shape memory alloy thin film and method of fabrication
US20030003295A1 (en) * 2000-11-27 2003-01-02 Dreher Andreas W. Apparatus and method of correcting higher-order aberrations of the human eye
US6884261B2 (en) * 2001-01-25 2005-04-26 Visiogen, Inc. Method of preparing an intraocular lens for implantation
US20030078658A1 (en) * 2001-01-25 2003-04-24 Gholam-Reza Zadno-Azizi Single-piece accomodating intraocular lens system
US20030078656A1 (en) * 2001-01-25 2003-04-24 Nguyen Tuan Anh Accommodating intraocular lens system with separation member
US20060069433A1 (en) * 2001-02-20 2006-03-30 Nulens, Ltd., Intraocular lens
US20030018384A1 (en) * 2001-07-17 2003-01-23 Medennium, Inc. Accommodative intraocular lens
US6709108B2 (en) * 2001-08-31 2004-03-23 Adaptive Optics Associates, Inc. Ophthalmic instrument with adaptive optic subsystem that measures aberrations (including higher order aberrations) of a human eye and that provides a view of compensation of such aberrations to the human eye
US20030060878A1 (en) * 2001-08-31 2003-03-27 Shadduck John H. Intraocular lens system and method for power adjustment
US20030050695A1 (en) * 2001-09-07 2003-03-13 Lin Chwen Yih Intraocular lens that may accommodate automatically
US8048155B2 (en) * 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
US20090005865A1 (en) * 2002-02-02 2009-01-01 Smiley Terry W Post-Implant Accommodating Lens Modification
US6860601B2 (en) * 2002-02-06 2005-03-01 John H. Shadduck Adaptive optic lens system and method of use
US6695881B2 (en) * 2002-04-29 2004-02-24 Alcon, Inc. Accommodative intraocular lens
US20040006386A1 (en) * 2002-06-28 2004-01-08 Valint Paul L. Surface modification of functional group-containing intraocular lenses
US20040001180A1 (en) * 2002-07-01 2004-01-01 Saul Epstein Variable focus lens with internal refractive surface
US20040006387A1 (en) * 2002-07-03 2004-01-08 Kelman Charles David Intraocular lens
US7494505B2 (en) * 2002-07-26 2009-02-24 Advanced Medical Optics, Inc. Method and device for manipulation of an intraocular lens
US20040039446A1 (en) * 2002-08-26 2004-02-26 Advanced Medical Optics, Inc. Accommodating intraocular lens assembly with multi-functional capsular bag ring
US20040054408A1 (en) * 2002-09-13 2004-03-18 Advanced Medical Optics, Inc. Accommodating intraocular lens assembly with aspheric optic design
US20040059343A1 (en) * 2002-09-25 2004-03-25 Kevin Shearer Novel enhanced system for intraocular lens insertion
US20040082993A1 (en) * 2002-10-25 2004-04-29 Randall Woods Capsular intraocular lens implant having a refractive liquid therein
US20040082994A1 (en) * 2002-10-25 2004-04-29 Randall Woods Accommodating intraocular lens implant
US20080046074A1 (en) * 2002-12-12 2008-02-21 Smith David J Accommodating Intraocular Lens System Having Spherical Aberration Compensation and Method
US20080046075A1 (en) * 2002-12-12 2008-02-21 Esch Victor C Accommodating Intraocular Lens System and Method
US7485144B2 (en) * 2002-12-12 2009-02-03 Powervision, Inc. Methods of adjusting the power of an intraocular lens
US20080015689A1 (en) * 2002-12-12 2008-01-17 Victor Esch Accommodating Intraocular Lens System and Method
US20050021139A1 (en) * 2003-02-03 2005-01-27 Shadduck John H. Ophthalmic devices, methods of use and methods of fabrication
US20070088433A1 (en) * 2005-10-17 2007-04-19 Powervision Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use
US20090030425A1 (en) * 2007-07-23 2009-01-29 Terah Whiting Smiley Lens Delivery System
US20090027661A1 (en) * 2007-07-23 2009-01-29 Steven Choi Systems and Methods for Testing Intraocular Lenses

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992609B2 (en) 2001-08-31 2015-03-31 Powervision, Inc. Intraocular lens system and method for power adjustment
US8048155B2 (en) * 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
US9456895B2 (en) 2002-02-02 2016-10-04 Powervision, Inc. Accommodating intraocular lens
US8425599B2 (en) 2002-02-02 2013-04-23 Powervision, Inc. Accommodating intraocular lenses and methods of use
US9795473B2 (en) 2002-12-12 2017-10-24 Powervision, Inc. Accommodating intraocular lenses
US8361145B2 (en) 2002-12-12 2013-01-29 Powervision, Inc. Accommodating intraocular lens system having circumferential haptic support and method
US9855137B2 (en) 2002-12-12 2018-01-02 Powervision, Inc. Accommodating intraocular lenses and methods of use
US8454688B2 (en) 2002-12-12 2013-06-04 Powervision, Inc. Accommodating intraocular lens having peripherally actuated deflectable surface and method
US9872762B2 (en) 2002-12-12 2018-01-23 Powervision, Inc. Accommodating intraocular lenses
US9277987B2 (en) 2002-12-12 2016-03-08 Powervision, Inc. Accommodating intraocular lenses
US9872763B2 (en) 2004-10-22 2018-01-23 Powervision, Inc. Accommodating intraocular lenses
US8158712B2 (en) 2007-02-21 2012-04-17 Powervision, Inc. Polymeric materials suitable for ophthalmic devices and methods of manufacture
US20090027661A1 (en) * 2007-07-23 2009-01-29 Steven Choi Systems and Methods for Testing Intraocular Lenses
US8314927B2 (en) 2007-07-23 2012-11-20 Powervision, Inc. Systems and methods for testing intraocular lenses
US8968396B2 (en) 2007-07-23 2015-03-03 Powervision, Inc. Intraocular lens delivery systems and methods of use
US9855139B2 (en) 2007-07-23 2018-01-02 Powervision, Inc. Intraocular lens delivery systems and methods of use
US9610155B2 (en) 2008-07-23 2017-04-04 Powervision, Inc. Intraocular lens loading systems and methods of use
US8447086B2 (en) 2009-08-31 2013-05-21 Powervision, Inc. Lens capsule size estimation
US8900298B2 (en) 2010-02-23 2014-12-02 Powervision, Inc. Fluid for accommodating intraocular lenses
US9220590B2 (en) 2010-06-10 2015-12-29 Z Lens, Llc Accommodative intraocular lens and method of improving accommodation
US9044317B2 (en) 2010-07-09 2015-06-02 Powervision, Inc. Intraocular lens delivery devices and methods of use
US8668734B2 (en) 2010-07-09 2014-03-11 Powervision, Inc. Intraocular lens delivery devices and methods of use
US9693858B2 (en) 2010-07-09 2017-07-04 Powervision, Inc. Intraocular lens delivery devices and methods of use
WO2012067994A3 (en) * 2010-11-15 2013-11-21 Elenza, Inc. Adaptive intraocular lens
US20150142106A1 (en) * 2012-02-22 2015-05-21 Omega Ophthalmics Llc Prosthetic capsular bag and method of inserting the same
US9439754B2 (en) * 2012-02-22 2016-09-13 Omega Opthalmics LLC Prosthetic capsular bag and method of inserting the same
US9364318B2 (en) 2012-05-10 2016-06-14 Z Lens, Llc Accommodative-disaccommodative intraocular lens
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
EP2906146A4 (en) * 2012-12-17 2016-06-29 Novartis Ag Capsule expander devices, systems, and methods for inhibiting capsular opacification and stabilizing the capsule
US20140172089A1 (en) * 2012-12-17 2014-06-19 Novartis Ag Capsule Expander Devices, Systems, and Methods for Inhibiting Capsular Opacification and Stabilizing the Capsule
WO2014099604A1 (en) 2012-12-17 2014-06-26 Novartis Ag Capsule expander devices, systems, and methods for inhibiting capsular opacification and stabilizing the capsule
JP2016500291A (en) * 2012-12-17 2016-01-12 ノバルティス アーゲー Capsule expander device for preventing a capsule opacification, to stabilize the capsule, systems, and methods
CN104936553A (en) * 2012-12-17 2015-09-23 诺华股份有限公司 Capsule expander devices, systems, and methods for inhibiting capsular opacification and stabilizing the capsule
US9339375B2 (en) * 2012-12-17 2016-05-17 Novartis Ag Capsule expander devices, systems, and methods for inhibiting capsular opacification and stabilizing the capsule
US9186244B2 (en) 2012-12-21 2015-11-17 Lensgen, Inc. Accommodating intraocular lens
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
US9642699B2 (en) 2014-06-19 2017-05-09 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
US9597176B2 (en) 2015-02-10 2017-03-21 Omega Ophthalmics Llc Overlapping side prosthetic capsular devices
US9554890B2 (en) 2015-02-10 2017-01-31 Omega Ophthalmics Llc Medicament delivery devices
US9522060B2 (en) 2015-02-10 2016-12-20 Omega Ophthalmics Llc Attachment structure prosthetic capsular devices
US9522059B2 (en) 2015-02-10 2016-12-20 Omega Ophthalmics Llc Insulated prosthetic capsular devices
US9517127B2 (en) 2015-02-10 2016-12-13 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
US9504558B2 (en) 2015-02-10 2016-11-29 Omega Ophthalmics Llc Attachable optic prosthetic capsular devices
US9763771B1 (en) 2015-02-10 2017-09-19 Omega Ophthalmics, LLC Prosthetic capsular devices, systems, and methods

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US20120078361A1 (en) 2012-03-29 application
US8048155B2 (en) 2011-11-01 grant
US8425599B2 (en) 2013-04-23 grant
US20140249625A1 (en) 2014-09-04 application
US9456895B2 (en) 2016-10-04 grant
US20170020662A1 (en) 2017-01-26 application
US20030149480A1 (en) 2003-08-07 application

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