US20080047866A1 - Blister Strip for an Inhaler - Google Patents

Blister Strip for an Inhaler Download PDF

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Publication number
US20080047866A1
US20080047866A1 US10/585,694 US58569405A US2008047866A1 US 20080047866 A1 US20080047866 A1 US 20080047866A1 US 58569405 A US58569405 A US 58569405A US 2008047866 A1 US2008047866 A1 US 2008047866A1
Authority
US
United States
Prior art keywords
layer
tearable
blister strip
strip according
blister
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/585,694
Other languages
English (en)
Inventor
Michel Quoniam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptar France SAS
Original Assignee
Valois SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valois SAS filed Critical Valois SAS
Assigned to VALOIS S.A.S. reassignment VALOIS S.A.S. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: QUONIAM, MICHEL
Publication of US20080047866A1 publication Critical patent/US20080047866A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips

Definitions

  • the present invention relates to a blister strip, and more particularly to a blister strip for use in a fluid or powder inhaler.
  • Blister strips are generally used for containing a substance, in particular a pharmaceutical substance, in predosed manner in a dispenser device, such as an inhaler. Each blister thus forms a reservoir containing an individual dose that is sealed in leaktight manner before use.
  • the device includes drive means which, each time they are actuated, bring a blister into a position that enables it to be opened, thereby releasing the dose of substance contained therein, with said does then being dispensed to the user.
  • Blister strips of that type generally include a layer of cavities containing the substance, and a tearable or peelable layer that is fastened on the cavity layer, and that enables each blister to be opened successively.
  • the entire surface of the blister must be opened, without presenting burrs or leaving residual portions of the torn layer remaining fastened to the blister, which are likely to retain some of the substance.
  • strips that are opened by peeling present an advantage compared to strips that are torn.
  • another problem can occur, in particular when the blister strip is used in an inhaler. Each time the inhaler is actuated, only one blister must be opened in order to avoid any risk of overdosing. In particular with strips that are opened by peeling, it can be difficult to guarantee that only one blister is opened each time the inhaler is actuated, and rather complex means must generally be implemented in order to ensure that functionality.
  • peelable strips Another problem that occurs with peelable strips relates to the compromise that must be found between the leaktightness of the blisters when they are sealed, and an opening capacity that must enable the device to open one blister at each actuation. That compromise is generally rather difficult to achieve, and, with that type of blister strip, generally prevents opening of the blister being triggered by the user inhaling.
  • An object of the present invention is to provide a blister strip that does not have the above-mentioned drawbacks.
  • an object of the present invention is to provide a blister strip that guarantees that the substance contained in the blister is completely sealed before the blister is opened.
  • an object of the present invention is to provide a blister strip that ensures that each strip is opened completely, guaranteeing that the entire dose contained in each blister is dispensed.
  • Another object of the present invention is to provide a blister strip that avoids any risk of overdosing.
  • Another object of the present invention is to provide a blister strip that can be used in an inhaler, with an opening system that is triggered by the user inhaling.
  • Another object of the present invention is to provide a blister strip that is simple and inexpensive to manufacture and to assemble.
  • the present invention thus provides a blister strip for use in a fluid or powder inhaler, and including a plurality of blisters, each formed by a reservoir including an opening that is sealed in leaktight manner by a tearable layer, the blister strip being characterized in that it comprises at least a base layer that is provided with openings forming the openings of the blisters, and a cavity layer that is provided with cavities forming the blister walls, said tearable layer comprising a first tearable-layer portion that is disposed between said base layer and said cavity layer, and a second tearable-layer portion that is disposed on the opposite side of said base layer, said first and second tearable-layer portions being connected together at each opening of the base portion.
  • the first and second tearable-layer portions are made from the same material, advantageously from polyethylene, preferably in the form of a continuous film of polyethylene having thickness that is less than 100 micrometers ( ⁇ m), advantageously lying in the range 10 ⁇ m to 40 ⁇ m, and preferably equal to 30 ⁇ m.
  • said first and second tearable-layer portions are connected together as a single part in each opening of the base layer, preferably by fusing material.
  • the base layer advantageously comprises polyester, and is preferably made in the form of a film having thickness that is less than 100 ⁇ m, advantageously lying in the range 40 ⁇ m to 60 ⁇ m, and preferably equal to 50 ⁇ m.
  • said cavity layer comprises polyethylene and/or polypropylene.
  • the tearable layer further includes a first aluminum layer that is fastened to said second tearable-layer portion, possibly by interposing a polyester layer and an adhesive layer, the aluminum layer having thickness that is less than 50 ⁇ m, advantageously lying in the range 10 ⁇ m to 30 ⁇ m, and preferably equal to 20 ⁇ m.
  • a first outer layer preferably formed by a printers' varnish, may also be provided on the tearable layer.
  • the cavity layer includes a second aluminum layer, possibly interposed with a polyester layer and an adhesive layer.
  • said cavity layer includes a second outer layer, preferably formed by a protective layer or by a layer of varnish, preferably interposed with an adhesive layer.
  • the adherence of the tearable layer to the base layer between the openings is different from the adherence in the proximity of said openings.
  • the blisters contain a pharmaceutical powder.
  • the present invention also provides a dry-powder inhaler including a blister strip as described above.
  • FIG. 1 is an exploded diagrammatic view of the structure of a blister strip constituting an advantageous embodiment of the present invention.
  • FIG. 2 is a diagrammatic perspective view of a blister strip, with a blister in the process of being opened.
  • FIG. 1 shows a blister-strip structure comprising thirteen different layers. However, it should be understood that some of the layers are optional, as explained in greater detail below.
  • the blister strips 20 of the invention include a plurality of blisters each formed by a reservoir 21 including an opening 25 .
  • the blister strip 20 comprises at least a base layer 6 that is provided with openings 25 forming the openings of the blisters.
  • a cavity layer 8 is provided, said cavity layer being provided with cavities 21 forming the walls of the blisters.
  • a tearable layer is provided for sealing each blister in leaktight manner, said tearable layer being torn open when the user wishes to dispense the dose of substance contained in the blister.
  • the substance is preferably a dry powder, in particular a pharmaceutical powder.
  • the tearable layer includes a first tearable-layer portion 7 that is disposed between said base layer 6 and said cavity layer 8 .
  • the tearable layer includes a second tearable-layer portion 5 that is disposed on the opposite side of said base layer 6 .
  • said first and second tearable-layer portions 7 , 5 are connected together. This connection is preferably made as a single part, advantageously by fusing material, and it is thus preferable to make the first and second tearable-layer portions from the same material.
  • the tearable layer can advantageously comprise polyethylene.
  • Each of the first and second tearable-layer portions 7 , 5 are advantageously constituted by a continuous film, in particular a polyethylene film, e.g.
  • an extruded polyethylene film that is applied to the base layer, and that has a thickness that can be less than 100 ⁇ m, advantageously lying in the range 10 ⁇ m to 40 ⁇ m, and preferably equal to 30 ⁇ m.
  • the base layer 6 advantageously comprises polyester, and can have a thickness that is less than 100 ⁇ m, advantageously lying in the range 40 ⁇ m to 60 ⁇ m, and preferably equal to 50 ⁇ m.
  • the cavity layer 8 can include polyethylene and/or polypropylene, and can be a little more rigid so to make it possible to form the cavities 21 forming the blisters.
  • the tearable layer can further include a first aluminum layer 2 of thickness that is less than 50 ⁇ m, advantageously lying in the range 10 ⁇ m to 30 ⁇ m, and preferably equal to 20 ⁇ m, and that is intended mainly to protect the contents of the blister against moisture.
  • the aluminum sheet 2 is advantageously fastened to the tearable layer, in particular to the second tearable-layer portion 5 , with a polyester film and an adhesive layer interposed therebetween.
  • the polyester layer 4 can be made in the form of a film having a thickness that is less than 50 ⁇ m, advantageously lying in the range 10 ⁇ m to 15 ⁇ m, and preferably 12 ⁇ m, and the adhesive can be any suitable glue.
  • a first outer layer 1 is provided that can advantageously be formed by a printers' varnish, making it easier to print an inscription on the tearable layer.
  • the cavity layer 8 can also include a second aluminum layer 11 , also intended mainly to protect against moisture. In similar manner, said second aluminum layer 11 can be fastened to the cavity layer 8 with a polyester layer 9 and a suitable adhesive layer 10 interposed therebetween.
  • a second outer layer 13 can be provided on the side including the cavity layer 8 , and is preferably formed by a protective layer or by a layer of varnish, and said second outer layer 13 can be fastened by means of an adhesive layer 12 . Interposing the polyester layers 4 and 9 can make it easier to fasten the aluminum layers 2 and 11 on each side of the blister strip 20 .
  • the multilayer structure is in fact formed of only two separable portions, a cavity portion constituted by layers 6 to 13 described in FIG. 1 , and a tear-off-strip portion A constituted by layers 1 to 5 described in FIG. 1 .
  • the multilayer structure can be made in a way that is different to the way described with reference to the FIG. 1 embodiment.
  • the blister strip of the invention is particularly adapted to be used in an inhaler, in particular of the type including a blister opening system that is actuated by inhalation.
  • the present invention makes it possible to provide the tearable layer 7 , 5 with an adherence to the base layer 6 , between the openings 25 , that can be different, in particular that adheres less well than the tearable layer 7 , 5 to the base layer 6 in the proximity of, or at, said openings 7 .
  • the opening force for each dose can therefore be adapted in optimum manner, while guaranteeing complete sealing by means of the material connection between the two tearable-layer portions.
  • the materials described with reference to the structure shown in FIG. 1 could also be modified, in particular using materials that are similar or that have suitable properties.
  • the base layer, the cavity layer, and the tearable layer could be made from any material that is suitable for this purpose, e.g. from the polyolefin family.
  • the thicknesses are given by way of indication, and could be provided in various ways.
  • the various layers could also be assembled relative to one another in any suitable manner.
US10/585,694 2004-01-14 2005-01-11 Blister Strip for an Inhaler Abandoned US20080047866A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0400313A FR2864944B1 (fr) 2004-01-14 2004-01-14 Bande de blisters pour inhalateur.
FR0400313 2004-01-14
PCT/FR2005/050014 WO2005068317A1 (fr) 2004-01-14 2005-01-11 Bande de blisters pour inhalateur

Publications (1)

Publication Number Publication Date
US20080047866A1 true US20080047866A1 (en) 2008-02-28

Family

ID=34684982

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/585,694 Abandoned US20080047866A1 (en) 2004-01-14 2005-01-11 Blister Strip for an Inhaler

Country Status (7)

Country Link
US (1) US20080047866A1 (fr)
EP (1) EP1706330B1 (fr)
JP (1) JP4528784B2 (fr)
CN (1) CN1910089A (fr)
DE (1) DE602005001199T2 (fr)
FR (1) FR2864944B1 (fr)
WO (1) WO2005068317A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011037551A2 (fr) 2009-09-23 2011-03-31 Mahmut Bilgic Bande alvéolée thermoformée contenant une combinaison qui renferme du tiotropium
US20150231332A1 (en) * 2007-05-04 2015-08-20 Powder Pharmaceuticals Incorporated Particle cassettes and processes therefor

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856144A (en) * 1973-01-15 1974-12-24 F Kelly Blister packaging assembly
US4938414A (en) * 1989-05-03 1990-07-03 Ludwig Lippert Postcard type mailing piece with removable message labels
US5533505A (en) * 1992-03-04 1996-07-09 Astra Aktiebolag Disposable inhaler
US5727687A (en) * 1993-07-26 1998-03-17 Klocke Verpackungs Service Gmbh Package for goods in pellets
US6056141A (en) * 1997-12-18 2000-05-02 Safta S.P.A. Reclosable packing system
US6155423A (en) * 1997-04-01 2000-12-05 Cima Labs Inc. Blister package and packaged tablet
US20020008046A1 (en) * 1995-10-31 2002-01-24 Fuller Kenneth E. Blister pill package with safety backing
US20030108714A1 (en) * 2001-12-07 2003-06-12 Bp Europack S.P.A. Multiple film sheet for containers with peel-off lids
US20030172927A1 (en) * 2000-02-01 2003-09-18 Elan Pharmaceutical Technologies Breath actuated dry powder inhaler and tape dose strip
US6637431B2 (en) * 1999-12-21 2003-10-28 Astrazeneca Ab Inhalation device employing blister packs with cavities and alignment slits
US20040118399A1 (en) * 2002-12-18 2004-06-24 Elan Pharmaceutical Technologies Unit dose dry powder inhaler

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09202355A (ja) * 1996-01-23 1997-08-05 Toppan Printing Co Ltd 滅菌用ブリスター包装用台紙およびブリスター包装体
GB0015043D0 (en) * 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
US20030203141A1 (en) * 2002-04-25 2003-10-30 Blum John B. Blister package
GB0209526D0 (en) * 2002-04-26 2002-06-05 Glaxo Group Ltd Medicament dispenser

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856144A (en) * 1973-01-15 1974-12-24 F Kelly Blister packaging assembly
US4938414A (en) * 1989-05-03 1990-07-03 Ludwig Lippert Postcard type mailing piece with removable message labels
US5533505A (en) * 1992-03-04 1996-07-09 Astra Aktiebolag Disposable inhaler
US5727687A (en) * 1993-07-26 1998-03-17 Klocke Verpackungs Service Gmbh Package for goods in pellets
US20020008046A1 (en) * 1995-10-31 2002-01-24 Fuller Kenneth E. Blister pill package with safety backing
US6155423A (en) * 1997-04-01 2000-12-05 Cima Labs Inc. Blister package and packaged tablet
US6056141A (en) * 1997-12-18 2000-05-02 Safta S.P.A. Reclosable packing system
US6637431B2 (en) * 1999-12-21 2003-10-28 Astrazeneca Ab Inhalation device employing blister packs with cavities and alignment slits
US20030172927A1 (en) * 2000-02-01 2003-09-18 Elan Pharmaceutical Technologies Breath actuated dry powder inhaler and tape dose strip
US20030108714A1 (en) * 2001-12-07 2003-06-12 Bp Europack S.P.A. Multiple film sheet for containers with peel-off lids
US20040118399A1 (en) * 2002-12-18 2004-06-24 Elan Pharmaceutical Technologies Unit dose dry powder inhaler

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150231332A1 (en) * 2007-05-04 2015-08-20 Powder Pharmaceuticals Incorporated Particle cassettes and processes therefor
US9358338B2 (en) * 2007-05-04 2016-06-07 Powder Pharmaceuticals Incorporated Particle cassettes and processes therefor
WO2011037551A2 (fr) 2009-09-23 2011-03-31 Mahmut Bilgic Bande alvéolée thermoformée contenant une combinaison qui renferme du tiotropium

Also Published As

Publication number Publication date
FR2864944A1 (fr) 2005-07-15
EP1706330A1 (fr) 2006-10-04
EP1706330B1 (fr) 2007-05-23
JP2007517737A (ja) 2007-07-05
JP4528784B2 (ja) 2010-08-18
WO2005068317A1 (fr) 2005-07-28
CN1910089A (zh) 2007-02-07
DE602005001199D1 (de) 2007-07-05
FR2864944B1 (fr) 2006-03-31
DE602005001199T2 (de) 2008-01-17

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Legal Events

Date Code Title Description
AS Assignment

Owner name: VALOIS S.A.S., FRANCE

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:QUONIAM, MICHEL;REEL/FRAME:018318/0391

Effective date: 20060818

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION