US20070221213A1 - Dosage aerosols for the application of pharmaceutical formulations - Google Patents
Dosage aerosols for the application of pharmaceutical formulations Download PDFInfo
- Publication number
- US20070221213A1 US20070221213A1 US11/691,890 US69189007A US2007221213A1 US 20070221213 A1 US20070221213 A1 US 20070221213A1 US 69189007 A US69189007 A US 69189007A US 2007221213 A1 US2007221213 A1 US 2007221213A1
- Authority
- US
- United States
- Prior art keywords
- amino
- phenyl
- quinazoline
- methoxy
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- QLHUUTWBSHECIH-UHFFFAOYSA-N C.O=C(OC1C[N+]2(CCCOC3=CC=CC=C3)CCC1CC2)C(O)(C1=CC=CS1)C1=CC=CS1 Chemical compound C.O=C(OC1C[N+]2(CCCOC3=CC=CC=C3)CCC1CC2)C(O)(C1=CC=CS1)C1=CC=CS1 QLHUUTWBSHECIH-UHFFFAOYSA-N 0.000 description 2
- OOGJQPCLVADCPB-UHFFFAOYSA-N CC1=CC(C(CCN(C(C)C)C(C)C)C2=CC=CC=C2)=C(O)C=C1 Chemical compound CC1=CC(C(CCN(C(C)C)C(C)C)C2=CC=CC=C2)=C(O)C=C1 OOGJQPCLVADCPB-UHFFFAOYSA-N 0.000 description 2
- 0 *[N+](CCC(C1=CC=CC=C1)C1=C(O)C=CC(C)=C1)(C(C)C)C(C)C.C Chemical compound *[N+](CCC(C1=CC=CC=C1)C1=C(O)C=CC(C)=C1)(C(C)C)C(C)C.C 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
- B65D83/753—Aerosol containers not provided for in groups B65D83/16 - B65D83/74 characterised by details or accessories associated with outlets
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
- C09K3/30—Materials not provided for elsewhere for aerosols
Definitions
- the invention relates to pharmaceutical active substances, active substance mixtures and formulations for use as an aerosol in propellant-containing [1.1.1.2-tetrafluoroethane (HFC-134a) or 1.1.1.2.3.3.3-heptafluoropropane(HFC-227)] metered-dose aerosols and the metered-dose aerosols for administering these active substances, active substance mixtures and formulations.
- propellant-containing 1.1.1.2-tetrafluoroethane (HFC-134a) or 1.1.1.2.3.3.3-heptafluoropropane(HFC-227)
- aerosol formulations of medicaments by pressurised, dosage-measuring inhalers (MDIs, standing for “metered-dose inhalers”) is widespread in therapy, as in the treatment of asthma and diseases that cause obstruction of the airways. Compared with oral administration, inhalation results a faster onset of activity and at the same time reduces systemic side-effects to a minimum. Aerosol formulations can be administered by inhalation through the mouth or topically by application to the nasal mucosa.
- Formulations for administering aerosol using MDIs may consist of solutions or suspensions.
- Solution formulations have the advantage over suspension formulations that the pharmaceutical compositions are fully dissolved in the propellant and thus have a homogeneous nature. Solution formulations also avoid the problems associated with suspension formulations of physical instability and thus ensure the administration of equal doses for a longer period.
- solution-type metered-dose aerosols generally do not require the addition of surfactants.
- the propellant contains a mixture of chlorofluorocarbons (CFCs) to guarantee the desired properties of solubility, vapour pressure and stability of the formulation.
- CFCs chlorofluorocarbons
- the environmentally harmful CFC propellant present in aerosol inhalation formulations is being replaced by environmentally acceptable partly fluorinated hydrocarbon propellants (HFC propellants) or other non-chlorinated propellants.
- the aim of the present invention is to provide a device with increased metering accuracy for the active substance, active substance mixture or formulation to prepare.
- the mouthpiece tube of the device has a channel ( 8 ) which has no or almost no dead volume on its side remote from the metered-dose aerosol.
- discharge volume is defined as the space which projects beyond the nozzle bore ( 9 ) and thus does not lie in the direct flow path.
- FIG. 1 shows a mouthpiece tube with dead volume
- FIG. 2 shows a mouthpiece tube with reduced dead volume
- FIGS. 3 and 4 show a mouthpiece tube (the mouthpiece tube according to the invention in each case) with optimised reduction of the dead volume;
- FIG. 5 shows a mouthpiece tube as in FIG. 1 a with reference numerals
- the mouthpiece tube is a component with a number of functions:
- the mouthpiece tube functionally consists of a shaft ( 2 ), a valve stem receptacle ( 5 ), a nozzle bore ( 9 ) and the mouthpiece ( 6 ).
- the mouthpiece tube shaft ( 2 ) has the function of safely preventing canting of the valve stem ( 4 ) relative to the other valve components ( 3 ), which would be harmful to the valve ( 3 ), by restricting the room for movement of the metered-dose aerosol.
- the valve stem receptacle ( 5 ) forms an abutment that limits the depth of immersion of the valve stem ( 4 ) in the stem receptacle of the mouthpiece tube.
- the valve stem receptacle has a channel ( 8 ) which the actual nozzle bore ( 9 ) impacts upon at an obtuse angle to its perpendicular axis.
- the nozzle bore has a diameter of 0.2-0.6 mm, preferably between 0.5-0.6 mm for suspension formulations and suslutions, as well as between 0.2-0.27 mm for solution formulations.
- the active substance formulation which is liquefied under pressure can be deflected through >90° from the perpendicularly downwardly arranged opening of the valve stem ( 7 ) and pass outwards through the nozzle bore ( 9 ).
- the spray cloud is finally generated at the transition from the nozzle bore ( 9 ) to the nozzle opening ( 10 ).
- the alteration to the mouthpiece tube described in the invention is achieved by a substantially more exact positioning of the tool part comprising the nozzle pin and the core of the valve stem receptacle to one another by a conventional injection moulding process.
- valve stems external diameter of the internal diameter of the valve Valve/manufacturer valve stem stem at the opening Bespak, BK357 3.17 ⁇ 0.01 mm 2.12 ⁇ 0.03 mm Valois, DF31/50RCU 3.19 ⁇ 0.01 mm 1.48 ⁇ 0.02 mm 3M, Neotechnic 2.76 ⁇ 0.01 mm 1.68 ⁇ 0.04 mm
- the channel ( 8 ) is connected, via a nozzle bore ( 9 ), to a nozzle opening of funnel-shaped construction.
- the device according to the invention is suitable for administering suitable active substance, or any suitable active substance mixture or formulation as single doses.
- Examples of pharmaceutically effective active substances, active substance mixtures, or formulations include all the inhalable compounds, such as, e.g., inhalable macromolecules, as disclosed in EP 1 003 478.
- inhalable compounds such as, e.g., inhalable macromolecules, as disclosed in EP 1 003 478.
- active substances, active substance mixtures or formulations for the treatment of respiratory complaints which are taken by inhalation are used.
- W is a pharmacologically active substance and is selected (for example) from among the betamimetics, anticholinergics, corticosteroids, PDE4-inhibitors, LTD4-antagonists, EGFR-inhibitors, dopamine agonists, H1-antihistamines, PAF-antagonists, and PI3-kinase inhibitors.
- W might be, for example:
- the compounds used as betamimetics are preferably compounds selected from among albuterol, arformoterol, bambuterol, bitolterol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, ibuterol, isoetharine, isoprenaline, levosalbutamol, mabuterol, meluadrine, metaproterenol, orciprenaline, pirbuterol, procaterol, reproterol, rimiterol, ritodrine, salmefamol, salmeterol, soterenol, sulphonterol, terbutaline, tiaramide, tolubuterol, zinterol, CHF-1035, HOKU-81, KUL-1248, and
- the anticholinergics used are preferably compounds selected from among the tiotropium salts, preferably the bromide salt, oxitropium salts, preferably the bromide salt, flutropium salts, preferably the bromide salt, ipratropium salts, preferably the bromide salt, glycopyrronium salts, preferably the bromide salt, trospium salts, preferably the chloride salt, tolterodine.
- the cations are the pharmacologically active constituents.
- the above-mentioned salts may preferably contain the chloride, bromide, iodide, sulphate, phosphate, methanesulphonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate or p-toluenesulphonate, while chloride, bromide, iodide, sulphate, methanesulphonate or p-toluenesulphonate are preferred as counter-ions.
- the chlorides, bromides, iodides, and methanesulphonates are particularly preferred.
- X ⁇ denotes an anion with a single negative charge, preferably an anion selected from among the fluoride, chloride, bromide, iodide, sulphate, phosphate, methanesulphonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate and p-toluenesulphonate, preferably an anion with a single negative charge, particularly preferably an anion selected from among the fluoride, chloride, bromide, methanesulphonate and p-toluenesulphonate, particularly preferably bromide, optionally in the form of the racemates, enantiomers or hydrates thereof.
- corticosteroids it is preferable to use compounds selected from among beclomethasone, betamethasone, budesonide, butixocort, ciclesonide, deflazacort, dexamethasone, etiprednol, flunisolide, fluticasone, loteprednol, mometasone, prednisolone, prednisone, rofleponide, triamcinolone, RPR-106541, NS-126, ST-26, and
- PDE4-inhibitors which may be used are preferably compounds selected from among enprofyllin, theophyllin, roflumilast, ariflo (cilomilast), tofimilast, pumafentrin, lirimilast, arofyllin, atizoram, D-4418, Bay-198004, BY343, CP-325.366, D-4396 (Sch-351591), AWD-12-281 (GW-842470), NCS-613, CDP-840, D-4418, PD-168787, T-440, T-2585, V-11294A, Cl-1018, CDC-801, CDC-3052, D-22888, YM-58997, Z-15370, and
- the LTD4-antagonists used are preferably compounds selected from among montelukast, pranlukast, zafirlukast, MCC-847 (ZD-3523), MN-001, MEN-91507 (LM-1507), VUF-5078, VUF-K-8707, L-733321 and
- EGFR-inhibitors which may be used are preferably compounds selected from among cetuximab, trastuzumab, ABX-EGF, Mab ICR-62, and
- the dopamine agonists used are preferably compounds selected from among bromocriptin, cabergoline, alpha-dihydroergocryptine, lisuride, pergolide, pramipexol, roxindol, ropinirol, talipexol, tergurid and viozan, optionally in the form of the racemates, enantiomers, diastereomers thereof and optionally in the form of the pharmacologically acceptable acid addition salts, solvates or hydrates thereof.
- these acid addition salts are preferably selected from among the hydrochloride, hydrobromide, hydriodide, hydrosulphate, hydrophosphate, hydromethanesulphonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydrooxalate, hydrosuccinate, hydrobenzoate, and hydro-p-toluenesulphonate.
- H1-Antihistamines which may be used are preferably compounds selected from among epinastine, cetirizine, azelastine, fexofenadine, levocabastine, loratadine, mizolastine, ketotifen, emedastine, dimetindene, clemastine, bamipine, cexchlorpheniramine, pheniramine, doxylamine, chlorophenoxamine, dimenhydrinate, diphenhydramine, promethazine, ebastine, desloratidine, and meclozine, optionally in the form of the racemates, enantiomers, diastereomers thereof and optionally in the form of the pharmacologically acceptable acid addition salts, solvates, or hydrates thereof.
- these acid addition salts are preferably selected from among the hydrochloride, hydrobromide, hydriodide, hydrosulphate, hydrophosphate, hydromethanesulphonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate, and hydro-p-toluenesulphonate.
- the compounds may come from the groups of ergot alkaloid derivatives, the triptans, the CGRP-inhibitors, the phosphodiesterase-V inhibitors, optionally in the form of the racemates, enantiomers, or diastereomers thereof, optionally in the form of the pharmacologically acceptable acid addition salts, the solvates, and/or hydrates thereof.
- Examples of ergot alkaloid derivatives are dihydroergotamine and ergotamine.
- suitable substances include pharmaceutical compositions, pharmaceutical formulations and mixtures with the above-mentioned active substances, as well as the salts and esters thereof and combinations of these active substances, salts, and esters.
- the pharmaceutical preparation may additionally contain standard commercial suspension adjuvants, surfactants and/or stabilisers.
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/020,200 US9937306B2 (en) | 2006-03-27 | 2011-02-03 | Dosage aerosols for the application of pharmaceutical formulations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006014433 | 2006-03-27 | ||
DE102006014433A DE102006014433A1 (de) | 2006-03-27 | 2006-03-27 | Dosieraerosole für die Verabreichung von pharmazeutischen Zubereitungen |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/020,200 Continuation US9937306B2 (en) | 2006-03-27 | 2011-02-03 | Dosage aerosols for the application of pharmaceutical formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070221213A1 true US20070221213A1 (en) | 2007-09-27 |
Family
ID=38176097
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/691,890 Abandoned US20070221213A1 (en) | 2006-03-27 | 2007-03-27 | Dosage aerosols for the application of pharmaceutical formulations |
US13/020,200 Active 2030-03-13 US9937306B2 (en) | 2006-03-27 | 2011-02-03 | Dosage aerosols for the application of pharmaceutical formulations |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/020,200 Active 2030-03-13 US9937306B2 (en) | 2006-03-27 | 2011-02-03 | Dosage aerosols for the application of pharmaceutical formulations |
Country Status (19)
Country | Link |
---|---|
US (2) | US20070221213A1 (ja) |
EP (1) | EP2001601B1 (ja) |
JP (1) | JP4903857B2 (ja) |
KR (1) | KR20080108141A (ja) |
CN (1) | CN101410189A (ja) |
AR (1) | AR060072A1 (ja) |
AU (1) | AU2007229531A1 (ja) |
BR (1) | BRPI0709198A2 (ja) |
CA (1) | CA2646612A1 (ja) |
DE (1) | DE102006014433A1 (ja) |
EA (1) | EA200801889A1 (ja) |
EC (1) | ECSP088732A (ja) |
MX (1) | MX2008011702A (ja) |
NO (1) | NO20083759L (ja) |
PE (1) | PE20071300A1 (ja) |
TW (1) | TW200815059A (ja) |
UY (1) | UY30241A1 (ja) |
WO (1) | WO2007110403A1 (ja) |
ZA (1) | ZA200807348B (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080041387A1 (en) * | 2004-03-05 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Impaction nozzle for propellant driven metered dose aerosols |
US20090020114A1 (en) * | 2007-07-03 | 2009-01-22 | Chiesi Farmaceutici S.P.A. | Metered dose inhaler actuator |
US20110186044A1 (en) * | 2006-03-27 | 2011-08-04 | Boehringer Ingelheim Pharma Gmbh &Co. Kg | Dosage aerosols for the application of pharmaceutical formulations |
JP2015071049A (ja) * | 2008-07-11 | 2015-04-16 | マップ・ファーマシューティカルズ・インコーポレイテッド | エアロゾル薬物送達のためのコンテナ |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2781012A1 (en) * | 2009-11-17 | 2011-05-26 | Cipla Limited | Inhalation solutions |
US9227030B2 (en) * | 2009-12-23 | 2016-01-05 | Map Pharmaceuticals, Inc. | Enhanced eductor design |
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DE102006014433A1 (de) | 2006-03-27 | 2007-10-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dosieraerosole für die Verabreichung von pharmazeutischen Zubereitungen |
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2006
- 2006-03-27 DE DE102006014433A patent/DE102006014433A1/de not_active Withdrawn
-
2007
- 2007-03-23 PE PE2007000319A patent/PE20071300A1/es not_active Application Discontinuation
- 2007-03-23 AR ARP070101191A patent/AR060072A1/es unknown
- 2007-03-26 WO PCT/EP2007/052857 patent/WO2007110403A1/de active Application Filing
- 2007-03-26 CA CA002646612A patent/CA2646612A1/en not_active Abandoned
- 2007-03-26 KR KR1020087026138A patent/KR20080108141A/ko not_active Application Discontinuation
- 2007-03-26 EA EA200801889A patent/EA200801889A1/ru unknown
- 2007-03-26 EP EP07727330.8A patent/EP2001601B1/de active Active
- 2007-03-26 JP JP2009502056A patent/JP4903857B2/ja active Active
- 2007-03-26 MX MX2008011702A patent/MX2008011702A/es not_active Application Discontinuation
- 2007-03-26 BR BRPI0709198-2A patent/BRPI0709198A2/pt not_active Application Discontinuation
- 2007-03-26 CN CNA200780011089XA patent/CN101410189A/zh active Pending
- 2007-03-26 AU AU2007229531A patent/AU2007229531A1/en not_active Abandoned
- 2007-03-26 UY UY30241A patent/UY30241A1/es not_active Application Discontinuation
- 2007-03-26 TW TW096110390A patent/TW200815059A/zh unknown
- 2007-03-27 US US11/691,890 patent/US20070221213A1/en not_active Abandoned
-
2008
- 2008-08-26 ZA ZA200807348A patent/ZA200807348B/xx unknown
- 2008-09-01 NO NO20083759A patent/NO20083759L/no not_active Application Discontinuation
- 2008-09-10 EC EC2008008732A patent/ECSP088732A/es unknown
-
2011
- 2011-02-03 US US13/020,200 patent/US9937306B2/en active Active
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Publication number | Priority date | Publication date | Assignee | Title |
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US20080041387A1 (en) * | 2004-03-05 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Impaction nozzle for propellant driven metered dose aerosols |
US7942146B2 (en) | 2004-03-05 | 2011-05-17 | Boehringer Ingelheim International Gmbh | Impaction nozzle for propellant driven metered dose aerosols |
US20110186044A1 (en) * | 2006-03-27 | 2011-08-04 | Boehringer Ingelheim Pharma Gmbh &Co. Kg | Dosage aerosols for the application of pharmaceutical formulations |
US9937306B2 (en) | 2006-03-27 | 2018-04-10 | Boehringer Ingelheim International Gmbh | Dosage aerosols for the application of pharmaceutical formulations |
US20090020114A1 (en) * | 2007-07-03 | 2009-01-22 | Chiesi Farmaceutici S.P.A. | Metered dose inhaler actuator |
JP2015071049A (ja) * | 2008-07-11 | 2015-04-16 | マップ・ファーマシューティカルズ・インコーポレイテッド | エアロゾル薬物送達のためのコンテナ |
Also Published As
Publication number | Publication date |
---|---|
AR060072A1 (es) | 2008-05-21 |
BRPI0709198A2 (pt) | 2011-06-28 |
JP4903857B2 (ja) | 2012-03-28 |
UY30241A1 (es) | 2007-10-31 |
EP2001601B1 (de) | 2014-05-14 |
WO2007110403A1 (de) | 2007-10-04 |
EP2001601A1 (de) | 2008-12-17 |
TW200815059A (en) | 2008-04-01 |
CN101410189A (zh) | 2009-04-15 |
EA200801889A1 (ru) | 2009-04-28 |
PE20071300A1 (es) | 2008-02-04 |
CA2646612A1 (en) | 2007-10-04 |
MX2008011702A (es) | 2008-09-24 |
NO20083759L (no) | 2008-10-21 |
DE102006014433A1 (de) | 2007-10-04 |
AU2007229531A1 (en) | 2007-10-04 |
ZA200807348B (en) | 2009-08-26 |
US9937306B2 (en) | 2018-04-10 |
ECSP088732A (es) | 2008-10-31 |
US20110186044A1 (en) | 2011-08-04 |
JP2009531102A (ja) | 2009-09-03 |
KR20080108141A (ko) | 2008-12-11 |
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Legal Events
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STCB | Information on status: application discontinuation |
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Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG, GERMANY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WACHTEL, HERBERT;HOELZ, HUBERT;ROHRSCHNEIDER, MARC;SIGNING DATES FROM 20070423 TO 20070430;REEL/FRAME:043726/0991 |