US20060231139A1 - Method and disposable device for sampling and distributing a liquid, for example, in sterile conditions - Google Patents

Method and disposable device for sampling and distributing a liquid, for example, in sterile conditions Download PDF

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Publication number
US20060231139A1
US20060231139A1 US10/548,443 US54844304A US2006231139A1 US 20060231139 A1 US20060231139 A1 US 20060231139A1 US 54844304 A US54844304 A US 54844304A US 2006231139 A1 US2006231139 A1 US 2006231139A1
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US
United States
Prior art keywords
liquid
distributed
valve
pipe
inlet pipe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/548,443
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English (en)
Inventor
Christian Neumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Stedim Biotech SA
Original Assignee
Stedim SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stedim SA filed Critical Stedim SA
Publication of US20060231139A1 publication Critical patent/US20060231139A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
    • G01N1/2035—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/2931—Diverse fluid containing pressure systems
    • Y10T137/3115—Gas pressure storage over or displacement of liquid

Definitions

  • the present invention relates to a method and disposable device for sampling and apportionment of liquid, in particular under sterile conditions.
  • connection/disconnection operations Today, this type of operation is carried out by separate, successive actions which multiply the connection/disconnection operations.
  • the multiplication of these connections/disconnections leads to a high risk of contamination, either by exposure to the air, or because of incorrect handling by the operator.
  • a standard application is, for example in parenteral nutrition, the preparation of batches of nutritive mixtures to be administered subsequently to the patient, from a certain number of stock solutions such as: a solution of amino acids, a glucose solution, a lipid emulsion, to which are added small volumes of complementary substrates such as trace elements, mineral salts and vitamins.
  • stock solutions such as: a solution of amino acids, a glucose solution, a lipid emulsion, to which are added small volumes of complementary substrates such as trace elements, mineral salts and vitamins.
  • composition of these mixtures is varied from day to day as a function of the nutritive state of the patient and the need to ensure that he has a suitable calorie intake.
  • a standard application is, for example in biotechnology, the repeated taking of samples from a solution in cell culture, throughout this same culture which extends over several days. This repeated sampling makes it possible to ensure counting of the cells in a given volume and thus to follow their growth curve, and even to carry out sterility tests on the samples taken in order to ensure the absence of any contamination.
  • this operation is generally carried out either on a laboratory table, or under a laminar air flow, or in controlled production zone.
  • This apportionment requires the reproducibility of each of the doses and the transfer of the latter in sterile mode. This operation is generally carried out on a laboratory table, under a laminar air flow.
  • the multiple inlet and outlet valve equipped with a non-return valve is arranged in order to let in the liquid to be distributed, to let it out towards the sampling and injection device, to let it in from the sampling and injection device without the possibility of apportionment by the entry of the liquid to be distributed (effect of the non-return valve), to let it out towards the outlet pipe.
  • Such non-return valves are well known. For example the valves marketed by the company Filtertek Inc (USA) under the name 3-way check valve can be mentioned.
  • the inlet pipe of liquid to be distributed is connected to a container containing said liquid to be distributed.
  • This container can be for example a bottle or a pouch.
  • This liquid inlet pipe is preferably equipped with a valve allowing or not allowing communication between the container and said inlet.
  • the inlet pipe for liquid to be distributed is connected to several containers containing several liquids to be distributed and preferably to a container containing a rinsing liquid.
  • said liquid inlet pipe can be supplied by several supply tubes, each preferably being equipped with a valve.
  • the gas inlet pipe can open directly into the multiple inlet and outlet valve.
  • a filter preferably a sterilizing filter is provided on the gas inlet pipe.
  • the gas for example the nitrogen or air coming from this pipe, is therefore sterile.
  • the collecting container is advantageously pre-connected, i.e. the container comprises connections allowing the direct mounting of said collecting container onto the outlet pipe(s).
  • This outlet pipe is preferably equipped with a branch leading to a waste container, equipped with a valve.
  • a rinsing fluid can thus be eliminated.
  • the multiple inlet and outlet valve is equipped with a pipe for a rinsing liquid.
  • the outlet pipe opens for example into 1, 2, preferably 3 and particularly 4 or more collecting containers of the liquid or liquids distributed.
  • the above liquid sampling and apportionment method is implemented under sterile conditions, particularly using disposable components.
  • a subject of the present Application is also a device which can be used in an above method for distribution of a fluid characterized in that it comprises a multiple inlet and outlet valve equipped with a non-return valve, said inlet and outlet valve being provided
  • the above inlet pipe for liquid to be distributed moreover includes an adaptation system for cooperating with a container containing a liquid to be distributed.
  • This adaptation system can be perforating, self-perforating, be screw or bayonet fitting, have aseptic connections etc.
  • the inlet pipe for liquid to be distributed comprises a shared section on the side of the multiple inlet and outlet valve and moreover a set of tubes for several containers containing a liquid to be distributed.
  • the gas inlet pipe is preferably connected onto the shared section of the inlet pipe for liquid to be distributed.
  • the outlet pipe comprises a shared section on the side of the multiple inlet and outlet valve and moreover a set of tubes for several containers having to contain a liquid to be distributed.
  • the inlet pipe is also the supply tube, advantageously in a single piece.
  • the method for distributing a fluid which is the subject of the present invention has very useful qualities.
  • plastic which is sterile and disposable:
  • FIG. 1 is a diagrammatic representation of an example of an assembly of the invention with multiple inlets and outlets.
  • FIG. 1 it is possible to discern the central element of the method and device according to the invention, a valve 1 with multiple inlets and outlets equipped with a non-return valve.
  • This non-return valve allows the introduction of the liquid drawn off into the rigid body of a syringe 2 and its transfer, without returning downstream, towards the apportionment line.
  • the above device can be used according to the following method:

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hydrology & Water Resources (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
US10/548,443 2003-03-11 2004-03-05 Method and disposable device for sampling and distributing a liquid, for example, in sterile conditions Abandoned US20060231139A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR03/03016 2003-03-11
FR0303016A FR2852259B1 (fr) 2003-03-11 2003-03-11 Procede et dispositif a usage unique d'echantillonnage et de repartition de liquide, notamment en conditions steriles
PCT/FR2004/000533 WO2004082829A2 (fr) 2003-03-11 2004-03-05 Procede et dispositif a usage unique d'echantillonnage et de repartition de liquide, notamment en conditions steriles

Publications (1)

Publication Number Publication Date
US20060231139A1 true US20060231139A1 (en) 2006-10-19

Family

ID=32893218

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/548,443 Abandoned US20060231139A1 (en) 2003-03-11 2004-03-05 Method and disposable device for sampling and distributing a liquid, for example, in sterile conditions

Country Status (13)

Country Link
US (1) US20060231139A1 (no)
EP (1) EP1608465A2 (no)
JP (1) JP2006524126A (no)
KR (1) KR20050107507A (no)
CN (1) CN1756523A (no)
AU (1) AU2004222541A1 (no)
BR (1) BRPI0408122A (no)
CA (1) CA2517898A1 (no)
FR (1) FR2852259B1 (no)
MX (1) MXPA05009672A (no)
NO (1) NO20053652L (no)
NZ (1) NZ542425A (no)
WO (1) WO2004082829A2 (no)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257998A1 (en) * 2005-05-09 2006-11-16 Uwe Klaus Supply system for cell culture module
WO2008055652A2 (en) * 2006-11-07 2008-05-15 Saxonia Biotec Gmbh Supply system for cell culture module
US20120122138A1 (en) * 2009-04-21 2012-05-17 Cymtox Limited Consumable component kit
WO2013087962A1 (es) * 2011-12-12 2013-06-20 Antonio Gonzalez Gonzalez Dispositivo cerrado para el rellenado de cámaras de goteo en equipos de administración de citostáticos, equipo de seguridad y sistema de rellenado que los integra.
US8820138B2 (en) 2009-03-31 2014-09-02 Avl Emission Test Systems Gmbh System for taking exhaust gas samples from internal combustion engines
CN105616160A (zh) * 2016-03-15 2016-06-01 王彦军 一种注射器助力操控设备
CN111247413A (zh) * 2017-10-20 2020-06-05 卢森堡科学技术研究院 自动水采样器设备

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0802216D0 (en) * 2008-02-07 2008-03-12 Hammersmith Imanet Ltd GMP dispenser for non-controlled environments
CN104873389B (zh) * 2009-07-29 2017-12-05 Icu医学有限公司 流体传输装置及使用方法
KR101040085B1 (ko) * 2009-09-29 2011-06-09 아메스산업(주) 프리믹싱이 가능한 실린지 펌프유닛을 구비한 시약 합성장치
KR101655814B1 (ko) 2015-02-10 2016-09-08 엘지전자 주식회사 차량의 리어뷰 미러 일체형 전방 카메라 모듈
ES2902746T3 (es) 2017-03-24 2022-03-29 Carefusion 303 Inc Bomba de válvula giratoria para mezclador automático de fármacos

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4084606A (en) * 1974-04-23 1978-04-18 Baxter Travenol Laboratories, Inc. Fluid transfer device
US4340153A (en) * 1980-11-28 1982-07-20 Spivey David L Method and apparatus for medication dispensing
US4433974A (en) * 1981-06-17 1984-02-28 Baxter Travenol Laboratories, Inc. Mixing system for parenteral liquids
US4915688A (en) * 1987-12-03 1990-04-10 Baxter International Inc. Apparatus for administering solution to a patient
US5037390A (en) * 1989-12-28 1991-08-06 Kenneth Raines System and method for mixing parenteral nutrition solutions
US5762769A (en) * 1995-03-29 1998-06-09 Toa Electronics Ltd. Method of measuring concentration of nonelectrolyte in electrolyte solution, method of preparing mixed solution containing electrolytes and nonelectrolytes and apparatus for preparing the solution
US20020107501A1 (en) * 2001-02-02 2002-08-08 Smith James E. Weight dependent, automatic filling dosage system and method of using same
US6446659B2 (en) * 1999-08-12 2002-09-10 Lancer Partnership Aseptic product dispensing system
US6450215B1 (en) * 2000-09-29 2002-09-17 Charter Medical, Ltd. Apparatus and method for filling bags

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3503320A1 (de) * 1985-01-31 1986-08-07 Baxter Travenol Laboratories, Inc., Deerfield, Ill. Mehrwegeventil
DE8516350U1 (de) * 1985-06-04 1988-10-27 Baxter Travenol Laboratories, Inc., Deerfield, Ill. Mehrwegeventil für eine Anordnung zur Herstellung oder Verabreichung von Infusionslösungen
DE3738162A1 (de) * 1987-11-10 1989-05-24 Baxter Travenol Lab System zur aufbewahrung, zubereitung und applikation von infusionsloesungen fuer die parenterale ernaehrung
IT1308253B1 (it) * 1999-03-16 2001-12-10 Molteni L E C Dei Flii Alitti Dosatore di precisione per liquidi.

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4084606A (en) * 1974-04-23 1978-04-18 Baxter Travenol Laboratories, Inc. Fluid transfer device
US4340153A (en) * 1980-11-28 1982-07-20 Spivey David L Method and apparatus for medication dispensing
US4433974A (en) * 1981-06-17 1984-02-28 Baxter Travenol Laboratories, Inc. Mixing system for parenteral liquids
US4915688A (en) * 1987-12-03 1990-04-10 Baxter International Inc. Apparatus for administering solution to a patient
US5037390A (en) * 1989-12-28 1991-08-06 Kenneth Raines System and method for mixing parenteral nutrition solutions
US5762769A (en) * 1995-03-29 1998-06-09 Toa Electronics Ltd. Method of measuring concentration of nonelectrolyte in electrolyte solution, method of preparing mixed solution containing electrolytes and nonelectrolytes and apparatus for preparing the solution
US5900136A (en) * 1995-03-29 1999-05-04 Toa Electronics Ltd. Method of measuring concentration of nonelectrolyte in electrolyte solution, method of preparing mixed solution containing electrolytes and nonelectrolytes and apparatus for preparing the solution
US6446659B2 (en) * 1999-08-12 2002-09-10 Lancer Partnership Aseptic product dispensing system
US6450215B1 (en) * 2000-09-29 2002-09-17 Charter Medical, Ltd. Apparatus and method for filling bags
US20020107501A1 (en) * 2001-02-02 2002-08-08 Smith James E. Weight dependent, automatic filling dosage system and method of using same

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257998A1 (en) * 2005-05-09 2006-11-16 Uwe Klaus Supply system for cell culture module
US7919307B2 (en) 2005-05-09 2011-04-05 Alpha Plan Gmbh Supply system for cell culture module
WO2008055652A2 (en) * 2006-11-07 2008-05-15 Saxonia Biotec Gmbh Supply system for cell culture module
WO2008055652A3 (en) * 2006-11-07 2008-07-03 Saxonia Biotec Gmbh Supply system for cell culture module
US20090311778A1 (en) * 2006-11-07 2009-12-17 Rudolph Luning Supply system for cell culture module
US8820138B2 (en) 2009-03-31 2014-09-02 Avl Emission Test Systems Gmbh System for taking exhaust gas samples from internal combustion engines
US20120122138A1 (en) * 2009-04-21 2012-05-17 Cymtox Limited Consumable component kit
WO2013087962A1 (es) * 2011-12-12 2013-06-20 Antonio Gonzalez Gonzalez Dispositivo cerrado para el rellenado de cámaras de goteo en equipos de administración de citostáticos, equipo de seguridad y sistema de rellenado que los integra.
CN105616160A (zh) * 2016-03-15 2016-06-01 王彦军 一种注射器助力操控设备
CN111247413A (zh) * 2017-10-20 2020-06-05 卢森堡科学技术研究院 自动水采样器设备

Also Published As

Publication number Publication date
BRPI0408122A (pt) 2006-03-01
EP1608465A2 (fr) 2005-12-28
WO2004082829A3 (fr) 2004-10-28
AU2004222541A1 (en) 2004-09-30
FR2852259B1 (fr) 2005-04-22
NO20053652L (no) 2005-09-27
WO2004082829A2 (fr) 2004-09-30
NO20053652D0 (no) 2005-07-27
MXPA05009672A (es) 2006-01-27
NZ542425A (en) 2007-03-30
FR2852259A1 (fr) 2004-09-17
CN1756523A (zh) 2006-04-05
CA2517898A1 (fr) 2004-09-30
KR20050107507A (ko) 2005-11-11
JP2006524126A (ja) 2006-10-26

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