US20060128783A1 - Tyrosine kinase inhibitors - Google Patents
Tyrosine kinase inhibitors Download PDFInfo
- Publication number
- US20060128783A1 US20060128783A1 US10/523,286 US52328605A US2006128783A1 US 20060128783 A1 US20060128783 A1 US 20060128783A1 US 52328605 A US52328605 A US 52328605A US 2006128783 A1 US2006128783 A1 US 2006128783A1
- Authority
- US
- United States
- Prior art keywords
- sulfonyl
- indole
- amino
- carboxamide
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
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- Diabetes (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
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- Endocrinology (AREA)
- Hematology (AREA)
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- Oncology (AREA)
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/523,286 US20060128783A1 (en) | 2002-08-09 | 2003-08-05 | Tyrosine kinase inhibitors |
| US11/890,755 US20080008708A1 (en) | 2002-08-09 | 2007-08-07 | Tyrosine kinase inhibitors |
| US12/605,690 US8008295B2 (en) | 2002-08-09 | 2009-10-26 | Tyrosine kinase inhibitors |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40248202P | 2002-08-09 | 2002-08-09 | |
| US10/523,286 US20060128783A1 (en) | 2002-08-09 | 2003-08-05 | Tyrosine kinase inhibitors |
| PCT/US2003/024393 WO2004014300A2 (en) | 2002-08-09 | 2003-08-05 | Tyrosine kinase inhibitors |
Related Child Applications (1)
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| US11/890,755 Abandoned US20080008708A1 (en) | 2002-08-09 | 2007-08-07 | Tyrosine kinase inhibitors |
| US12/605,690 Expired - Fee Related US8008295B2 (en) | 2002-08-09 | 2009-10-26 | Tyrosine kinase inhibitors |
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| US12/605,690 Expired - Fee Related US8008295B2 (en) | 2002-08-09 | 2009-10-26 | Tyrosine kinase inhibitors |
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| US (3) | US20060128783A1 (de) |
| EP (1) | EP1534268A4 (de) |
| JP (2) | JP4335136B2 (de) |
| AU (1) | AU2003257170B2 (de) |
| CA (1) | CA2493575A1 (de) |
| WO (1) | WO2004014300A2 (de) |
Cited By (2)
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|---|---|---|---|---|
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| CN112375027A (zh) * | 2020-12-07 | 2021-02-19 | 中国药科大学 | 吲哚磺酰胺类衍生物及其医药用途 |
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| AU2003261415C1 (en) | 2002-08-09 | 2010-01-14 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| US7915443B2 (en) | 2006-11-16 | 2011-03-29 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
| CN1993333B (zh) * | 2004-08-04 | 2012-08-01 | 大正制药株式会社 | 三唑衍生物 |
| PL1791537T3 (pl) | 2004-08-19 | 2010-04-30 | Aventis Pharma Inc | Pochodne 3-arylotioindolo-2-karboksamidów i ich analogi jako inhibitory kinazy kazeinowej I |
| GB0423554D0 (en) | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
| EP1899340A4 (de) * | 2005-06-28 | 2009-09-16 | Merck & Co Inc | Nicht-nukleosidische reverse-transkriptase-hemmer |
| AU2006267338B2 (en) | 2005-07-13 | 2012-08-16 | Msd K.K. | Heterocycle-substituted benzimidazole derivative |
| CA2649994A1 (en) | 2006-04-26 | 2007-11-08 | Cancer Research Technology Limited | Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds |
| WO2008060998A1 (en) * | 2006-11-10 | 2008-05-22 | Wyeth | Indole sulfonamides as sfrp-1 modulators |
| US8558002B2 (en) | 2006-11-16 | 2013-10-15 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
| US8143410B2 (en) | 2006-11-16 | 2012-03-27 | Allergan, Inc. | Kinase inhibitors |
| JP5463285B2 (ja) * | 2007-07-13 | 2014-04-09 | アイカジェン， インコーポレイテッド | ナトリウムチャネル阻害物質 |
| DK2229391T3 (da) | 2007-12-19 | 2014-10-13 | Cancer Res Inst Royal | Pyrido[2,3-B]pyrazin-8-substituerede forbindelser og deres anvendelse |
| CA2716332A1 (en) * | 2008-02-22 | 2009-08-27 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| GB0807609D0 (en) | 2008-04-25 | 2008-06-04 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| CN102906090B (zh) | 2010-02-01 | 2015-06-24 | 癌症研究技术有限公司 | 1-(5-叔丁基-2-苯基-2h-吡唑-3-基)-3-[2-氟-4-(1-甲基-2-氧代-2,3-二氢-1h-咪唑并[4,5-b]吡啶-7-基氧基)-苯基]-脲和相关化合物及它们在治疗中的应用 |
| US9708276B2 (en) | 2011-10-12 | 2017-07-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer |
| JP6564380B2 (ja) | 2013-09-20 | 2019-08-21 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 前立腺癌を治療するための化合物 |
| US20160257657A1 (en) | 2013-09-20 | 2016-09-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US10980806B2 (en) | 2016-03-24 | 2021-04-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
| CN109563057B (zh) * | 2016-05-31 | 2022-06-24 | 大鹏药品工业株式会社 | 磺酰胺化合物或其盐 |
| US10889555B2 (en) | 2016-05-31 | 2021-01-12 | Taiho Pharmaceutical Co., Ltd. | Sulfonamide compound or salt thereof |
| KR102404865B1 (ko) * | 2017-11-29 | 2022-06-02 | 다이호야쿠힌고교 가부시키가이샤 | 항종양제 |
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| US5527819A (en) * | 1991-09-06 | 1996-06-18 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
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| JPS5818358A (ja) * | 1981-07-16 | 1983-02-02 | イ−・アイ・デユポン・デ・ニモアス・アンド・カンパニ− | 除草性インド−ルスルホネ−ト類 |
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| BR9405737A (pt) * | 1993-02-24 | 1995-12-05 | Merck & Co Inc | Composto processo de inibição de transcriptase reserva de HIV, processo de prevenção contra a infecção pelo HIV ou de tratamento da infecção pelo HIV, composição farmacêutica útil para a inibição da transcriptase reserva de HIV, e, útil para a prevenção ou tratamento de infecção pelo HIV ou para o tratamento da AIDS ou ARC |
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| JP4623962B2 (ja) * | 2001-10-22 | 2011-02-02 | ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
| AU2003261415C1 (en) * | 2002-08-09 | 2010-01-14 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
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2003
- 2003-08-05 JP JP2004527739A patent/JP4335136B2/ja not_active Expired - Fee Related
- 2003-08-05 EP EP03784904A patent/EP1534268A4/de not_active Withdrawn
- 2003-08-05 CA CA002493575A patent/CA2493575A1/en not_active Abandoned
- 2003-08-05 AU AU2003257170A patent/AU2003257170B2/en not_active Ceased
- 2003-08-05 WO PCT/US2003/024393 patent/WO2004014300A2/en active Application Filing
- 2003-08-05 US US10/523,286 patent/US20060128783A1/en not_active Abandoned
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2007
- 2007-08-07 US US11/890,755 patent/US20080008708A1/en not_active Abandoned
-
2009
- 2009-05-01 JP JP2009111780A patent/JP2009235072A/ja active Pending
- 2009-10-26 US US12/605,690 patent/US8008295B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3180875A (en) * | 1963-10-07 | 1965-04-27 | Upjohn Co | Derivatives of 3, 3'-dithiobis[indole-2-carboxylic acid] dihydrazides |
| US5527819A (en) * | 1991-09-06 | 1996-06-18 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| CN112375027A (zh) * | 2020-12-07 | 2021-02-19 | 中国药科大学 | 吲哚磺酰胺类衍生物及其医药用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003257170B2 (en) | 2008-12-11 |
| EP1534268A4 (de) | 2006-11-02 |
| US20080008708A1 (en) | 2008-01-10 |
| AU2003257170A1 (en) | 2004-02-25 |
| JP2006504668A (ja) | 2006-02-09 |
| EP1534268A2 (de) | 2005-06-01 |
| US20100041652A1 (en) | 2010-02-18 |
| JP4335136B2 (ja) | 2009-09-30 |
| CA2493575A1 (en) | 2004-02-19 |
| WO2004014300A2 (en) | 2004-02-19 |
| US8008295B2 (en) | 2011-08-30 |
| WO2004014300A3 (en) | 2004-04-22 |
| JP2009235072A (ja) | 2009-10-15 |
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