US20060058710A1 - Ultrasound wound treatment method and device using standing waves - Google Patents

Ultrasound wound treatment method and device using standing waves Download PDF

Info

Publication number
US20060058710A1
US20060058710A1 US11/232,801 US23280105A US2006058710A1 US 20060058710 A1 US20060058710 A1 US 20060058710A1 US 23280105 A US23280105 A US 23280105A US 2006058710 A1 US2006058710 A1 US 2006058710A1
Authority
US
United States
Prior art keywords
ultrasound
waves
wound
ultrasonic
standing waves
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/232,801
Inventor
Eilaz Babaev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celleration Inc
Original Assignee
Celleration Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celleration Inc filed Critical Celleration Inc
Priority to US11/232,801 priority Critical patent/US20060058710A1/en
Publication of US20060058710A1 publication Critical patent/US20060058710A1/en
Assigned to CELLERATION, INC. reassignment CELLERATION, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: ADVANCED MEDICAL APPLICATIONS, INC.
Assigned to CELLERATION, INC. reassignment CELLERATION, INC. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: CELLERATION, INC.
Assigned to ADVANCED MEDICAL APPLICATIONS, INC. reassignment ADVANCED MEDICAL APPLICATIONS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BABAEV, EILAZ
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy

Definitions

  • the present invention relates to the treatment of wounds using ultrasound standing waves.
  • the present invention relates to a method and device of creating ultrasonic standing waves in air and directing them to a wound for delivering aerodynamic forces as ultrasonic radiation pressure and ultrasonic waves as well.
  • Ultrasound radiation pressure increases the blood flow in the wound area, and ultrasound waves kill bacteria, stimulate healthy tissue cells, and treat the wound.
  • Ultrasonic waves have been widely used in medical applications, including diagnostics and therapy as well as many industrial applications, e.g., welding, cutting, fiber optics technology, speed meters, etc.
  • Diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or human tissue.
  • an ultrasonic transducer is placed in contact with the tissue or object via a coupling medium, and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue.
  • the waves are reflected back to a receiver adjacent the transducer.
  • an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors, etc.
  • ultrasound waves Three therapeutic medical uses include aerosol mist production, contact physiotherapy, and soft tissue ablation.
  • the ultrasound contact physiotherapy procedure may cause a patient significant discomfort and/or pain, and skin may appear raw and damaged.
  • Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drugs to the lungs.
  • Ultrasonic nebulizers operate by passing ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid from a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound. This technique can produce a very fine dense fog or mist.
  • Aerosol mists produced by ultrasound are preferred because a smaller particle size of the aerosol can be obtained with the ultrasonic waves.
  • One of the major shortcomings of ultrasonic inhalers and nebulizers is that there is no directed aerosol to the target. An air stream is then required to direct the aerosol to the target, but this decreases the efficiency of ultrasound.
  • Ultrasonic sprayers (Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc., Zevex International, Inc., operate by passing liquid trough central orifice of ultrasound instrument-tip. See, for example, U.S. Pat. Nos. 3,765,606; 4,659,014; 5,104,042; 4,9307,00; 4,153,201; 4,655,393; 5,516,043; 5,835,678; 5,879,364; and 5,843,139.
  • Ultrasonic inhalers and drug delivery systems from Medisonic USA, Inc., 3M, Siemens Gmb, The Procter & Gamble Company, Sheffield Pharmaceuticals, Aradigm, Inc. operate by atomizing liquid using piezoceramic film. See, for example, U.S. Pat. Nos. 4,294,407; 5,347,998; 5,520,166; 5,960,792; 6,095,141; 6,102,298; 6,098,620; 6,026,808; and 6,106,547.
  • the present invention is a method and device for using ultrasonic standing waves to treat wounds.
  • Ultrasound standing waves occur as a result of incident and reflected waves from a reflective surface that are traveling in opposite directions.
  • the resultant superposition of the two waves forms standing waves, which create ultrasonic radiation pressure.
  • the standing waves actually ultrasound radiation pressure, occur when the distance between (a) the distal end of a transducer (as a radiant of ultrasound waves) and (b) the reflected surface (e.g., a wound surface) is: n X ⁇ /2, where ⁇ is the wave length and n is a positive integer.
  • the standing waves are more effective in limited space or area as a tube.
  • ultrasound waves are created, directed, and delivered to a wound surface through the air to increase blood flow, kill bacteria, stimulate healthy tissue cells and treat wounds with ultrasound energy.
  • the method of treating wounds involves the use of ultrasound standing waves of a continuous or pulsed ultrasound.
  • the method of the invention comprises producing ultrasound standing waves using a free end surface of an ultrasonic transducer and wound surface.
  • the radiation pressure of ultrasonic standing waves increase blood flow in wound area and destroy the surface bacteria to result in a higher disinfecting property of ultrasound. Additionally, the ultrasound also stimulates healthy cell growth to aid in granulization and epithelization of the healing tissue.
  • Other applications of the method can be directed to non-medical uses such as cleansing, drying, sterilizing and coating surfaces of objects and food.
  • the method of the present invention offers an approach that may re-establish use of some traditional ultrasound and establish a method of treating wound and fighting bacteria without antibiotics when necessary.
  • the overall concept of the present invention relates in method and apparatus for wound treatment using ultrasonic standing waves through air with no drug.
  • This wound treatment method is possible with combination of different energy sources as an ultrasound, laser, electric current, magnetic field, ultraviolet, microwaves, radio frequency, etc.
  • FIG. 1 is a perspective view of an ultrasound wound treatment system with standing waves, according to the present invention
  • FIG. 2 is a schematic, lateral cross-sectional view of another transducer useful with the system of FIG. 1 .
  • FIG. 3 is a schematic, lateral cross-sectional view of a transducer having a bushing
  • FIG. 4 is a schematic, lateral cross-sectional view of a transducer of FIG. 3 where the distal tip has been modified to provide a focused beam;
  • FIG. 5 is a schematic, lateral cross-sectional view of an embodiment of the invention intended to facilitate dissolution of blood clots.
  • the present invention is a method and system, which uses ultrasound standing wave energy to treat wounds.
  • the system comprises a generator of electrical signals and a handpiece having an ultrasound transducer and tip.
  • FIG. 1 A system for wound treatment according to present invention is illustrated in FIG. 1 .
  • the system 2 comprises a signal generator 4 operatively or electrically connected through cable 6 to a transducer 8 in a housing 10 .
  • Transducer 8 has an ultrasound tip 12 that generates standing ultrasound waves 14 .
  • Standing ultrasound waves 14 are directed to the surface 16 of a wound 18 .
  • Standing ultrasound waves 14 occur when activated ultrasound tip 12 is directed through the air to a wound surface 16 as a result of incident and reflected waves from wound surface 16 , which creates ultrasonic radiation pressure.
  • the distal end 20 of transducer tip 12 (as a radiant of ultrasound waves) is preferably a distance d from wound surface 16 (a source of reflected waves).
  • ultrasound transducer 8 or tip 12 must frequently be moved back and forward toward wound surface 16 by an operator.
  • the waveform of the ultrasound waves generated by transducer 8 preferably corresponds to the waveform of the electrical signals generated by signal generator 4 .
  • electrical signals from signal generator 4 with rectangular, sinusoidal, trapezoidal, or triangular waveforms will cause transducer 8 to produce respective similarly shaped ultrasound waveforms.
  • the standing waves are more effective in limited space or area such as a tube.
  • a bushing 26 increases ultrasound radiation pressure.
  • Bushing 26 may or may not be disposable part on the distal end 28 of housing 10 .
  • the distal end 28 of ultrasonic tip 12 has been modified to a concave shape to focus ultrasound waves 14 .
  • ultrasound tip 12 is directed to a blood vessel 30 with clot or clots 32 .
  • ultrasound standing waves 34 create cavitation inside blood vessel 30 and dissolve clot or clots 32 .
  • a wound can also be treated with a gel or drug. After the gel or drug is applied to the wound surface, ultrasound standing waves would be directed to the wound. The drug would be activated and penetrate into tissue under ultrasound radiation pressure.
  • Additional possible application of method using ultrasound standing waves is for the diffusion of grafts to a wound with radiation pressure gently.
  • the ultrasound transducer operates at a frequency from 10 kHz to 10,000 MHz and the distance d is at least 0.1 inch.

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Surgical Instruments (AREA)
  • Fixed Capacitors And Capacitor Manufacturing Machines (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heating, Cooling, Or Curing Plastics Or The Like In General (AREA)
  • Treatment Of Fiber Materials (AREA)
  • Processing Of Meat And Fish (AREA)

Abstract

The method and device of the present invention for wound treatment with ultrasound standing waves includes a transducer probe to produce ultrasonic waves. The ultrasonic transducer has a tip with a distal radiation surface that radiates ultrasound energy toward the surface of a wound. Ultrasound standing waves occurring as a result of incident and reflected waves from the wound surface create ultrasonic radiation pressure. Ultrasound radiation pressure increases the blood flow in wound area, and ultrasound waves kill bacteria, stimulate healthy tissue cell and treat wounds.

Description

    FIELD OF INVENTION
  • The present invention relates to the treatment of wounds using ultrasound standing waves. In particular, the present invention relates to a method and device of creating ultrasonic standing waves in air and directing them to a wound for delivering aerodynamic forces as ultrasonic radiation pressure and ultrasonic waves as well. Ultrasound radiation pressure increases the blood flow in the wound area, and ultrasound waves kill bacteria, stimulate healthy tissue cells, and treat the wound.
    • BACKGROUND OF THE INVENTION
  • Ultrasonic waves have been widely used in medical applications, including diagnostics and therapy as well as many industrial applications, e.g., welding, cutting, fiber optics technology, speed meters, etc. Diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or human tissue. In this method, an ultrasonic transducer is placed in contact with the tissue or object via a coupling medium, and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue. Upon contact with the various underlying structures, the waves are reflected back to a receiver adjacent the transducer. By comparison of the signals of the ultrasonic waves sent with the reflected ultrasonic wave as received, an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors, etc.
  • Three therapeutic medical uses of ultrasound waves include aerosol mist production, contact physiotherapy, and soft tissue ablation. The ultrasound contact physiotherapy procedure may cause a patient significant discomfort and/or pain, and skin may appear raw and damaged. Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drugs to the lungs.
  • Ultrasonic nebulizers operate by passing ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid from a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound. This technique can produce a very fine dense fog or mist.
  • Aerosol mists produced by ultrasound are preferred because a smaller particle size of the aerosol can be obtained with the ultrasonic waves. One of the major shortcomings of ultrasonic inhalers and nebulizers is that there is no directed aerosol to the target. An air stream is then required to direct the aerosol to the target, but this decreases the efficiency of ultrasound.
  • Ultrasonic sprayers (Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc., Zevex International, Inc., operate by passing liquid trough central orifice of ultrasound instrument-tip. See, for example, U.S. Pat. Nos. 3,765,606; 4,659,014; 5,104,042; 4,9307,00; 4,153,201; 4,655,393; 5,516,043; 5,835,678; 5,879,364; and 5,843,139.
  • Ultrasonic inhalers and drug delivery systems from Medisonic USA, Inc., 3M, Siemens Gmb, The Procter & Gamble Company, Sheffield Pharmaceuticals, Aradigm, Inc., operate by atomizing liquid using piezoceramic film. See, for example, U.S. Pat. Nos. 4,294,407; 5,347,998; 5,520,166; 5,960,792; 6,095,141; 6,102,298; 6,098,620; 6,026,808; and 6,106,547.
    • OBJECT OF THE INVENTION
  • It is an object of the invention to provide an improved method and device for treating wounds.
  • It is also an object of this invention to provide an improved method and device for treating wounds using ultrasound standing waves.
  • It is a further object of the invention to provide a method and device for increasing blood flow, killing bacteria, and stimulating healthy tissue cell growth.
  • These and other objects of the invention will become more apparent from the discussion below.
    • SUMMARY OF INVENTION
  • The present invention is a method and device for using ultrasonic standing waves to treat wounds. Ultrasound standing waves occur as a result of incident and reflected waves from a reflective surface that are traveling in opposite directions. The resultant superposition of the two waves forms standing waves, which create ultrasonic radiation pressure. The standing waves, actually ultrasound radiation pressure, occur when the distance between (a) the distal end of a transducer (as a radiant of ultrasound waves) and (b) the reflected surface (e.g., a wound surface) is: n X λ/2, where λ is the wave length and n is a positive integer. The standing waves are more effective in limited space or area as a tube.
  • According to the invention ultrasound waves are created, directed, and delivered to a wound surface through the air to increase blood flow, kill bacteria, stimulate healthy tissue cells and treat wounds with ultrasound energy. The method of treating wounds involves the use of ultrasound standing waves of a continuous or pulsed ultrasound.
  • More particularly, the method of the invention comprises producing ultrasound standing waves using a free end surface of an ultrasonic transducer and wound surface.
  • According to the method of the present invention, the radiation pressure of ultrasonic standing waves increase blood flow in wound area and destroy the surface bacteria to result in a higher disinfecting property of ultrasound. Additionally, the ultrasound also stimulates healthy cell growth to aid in granulization and epithelization of the healing tissue. Other applications of the method can be directed to non-medical uses such as cleansing, drying, sterilizing and coating surfaces of objects and food.
  • The method of the present invention offers an approach that may re-establish use of some traditional ultrasound and establish a method of treating wound and fighting bacteria without antibiotics when necessary.
  • The overall concept of the present invention relates in method and apparatus for wound treatment using ultrasonic standing waves through air with no drug. This wound treatment method is possible with combination of different energy sources as an ultrasound, laser, electric current, magnetic field, ultraviolet, microwaves, radio frequency, etc.
    • BRIEF DESCRIPTION OF DRAWINGS
  • FIG. 1 is a perspective view of an ultrasound wound treatment system with standing waves, according to the present invention;
  • FIG. 2 is a schematic, lateral cross-sectional view of another transducer useful with the system of FIG. 1.
  • FIG. 3 is a schematic, lateral cross-sectional view of a transducer having a bushing;
  • FIG. 4 is a schematic, lateral cross-sectional view of a transducer of FIG. 3 where the distal tip has been modified to provide a focused beam; and
  • FIG. 5 is a schematic, lateral cross-sectional view of an embodiment of the invention intended to facilitate dissolution of blood clots.
    • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The present invention is a method and system, which uses ultrasound standing wave energy to treat wounds. The system comprises a generator of electrical signals and a handpiece having an ultrasound transducer and tip.
  • The invention can perhaps be better appreciated from the drawings. A system for wound treatment according to present invention is illustrated in FIG. 1. The system 2 comprises a signal generator 4 operatively or electrically connected through cable 6 to a transducer 8 in a housing 10. Transducer 8 has an ultrasound tip 12 that generates standing ultrasound waves 14. Standing ultrasound waves 14 are directed to the surface 16 of a wound 18.
  • Standing ultrasound waves 14 occur when activated ultrasound tip 12 is directed through the air to a wound surface 16 as a result of incident and reflected waves from wound surface 16, which creates ultrasonic radiation pressure. The distal end 20 of transducer tip 12 (as a radiant of ultrasound waves) is preferably a distance d from wound surface 16 (a source of reflected waves). Distance d is related to the wavelength k of the ultrasound wave or signal by the formula
    d=nXλ/2
    where n is a positive integer. To reach this preferred distance and therefore effect wound treatment practice, ultrasound transducer 8 or tip 12 must frequently be moved back and forward toward wound surface 16 by an operator.
  • The waveform of the ultrasound waves generated by transducer 8 preferably corresponds to the waveform of the electrical signals generated by signal generator 4. For example, electrical signals from signal generator 4 with rectangular, sinusoidal, trapezoidal, or triangular waveforms will cause transducer 8 to produce respective similarly shaped ultrasound waveforms.
  • The standing waves are more effective in limited space or area such as a tube. In each of FIGS. 3 to 5 a bushing 26 increases ultrasound radiation pressure. Bushing 26 may or may not be disposable part on the distal end 28 of housing 10.
  • In the embodiment of the invention set forth in FIG. 4 the distal end 28 of ultrasonic tip 12 has been modified to a concave shape to focus ultrasound waves 14.
  • One of the possible applications of the method of present invention is the facilitation of dissolution of blood clots by using ultrasound energy. In FIG. 5 ultrasound tip 12 is directed to a blood vessel 30 with clot or clots 32. In this case ultrasound standing waves 34 create cavitation inside blood vessel 30 and dissolve clot or clots 32.
  • In another embodiment of the present invention a wound can also be treated with a gel or drug. After the gel or drug is applied to the wound surface, ultrasound standing waves would be directed to the wound. The drug would be activated and penetrate into tissue under ultrasound radiation pressure.
  • Additional possible application of method using ultrasound standing waves is for the diffusion of grafts to a wound with radiation pressure gently.
  • It is provided that the ultrasound transducer operates at a frequency from 10 kHz to 10,000 MHz and the distance d is at least 0.1 inch.
  • The preceding specific embodiments are illustrative of the practice of the invention. It is to be understood, however, that other expedients known to those skilled in the art or disclosed herein may be employed without departing from the spirit of the invention or the scope of the appended claims.

Claims (5)

1-8. (canceled)
9. A system for treating a wound with ultrasound standing waves, comprising:
means for generating ultrasound waves including an ultrasound transducer having a distal radiation surface; and
means for creating at least one ultrasound standing wave by adjusting the distance between the distal radiation surface and a surface of the wound, wherein the at least one ultrasound standing wave creates radiation pressure for providing a bactericidal and a therapeutic effect to the wound for decreasing the healing time for the wound.
10. The system of claim 9, wherein the ultrasound transducer operates at a frequency of from about 10 KHz to 103 MHz.
11. The system of claim 9, wherein the distal end of the ultrasound transducer comprises a bushing, wherein the distance between the bushing and the surface of the wound is adjusted for creating the at least one ultrasound standing wave.
12-18. (canceled)
US11/232,801 2001-01-30 2005-09-22 Ultrasound wound treatment method and device using standing waves Abandoned US20060058710A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/232,801 US20060058710A1 (en) 2001-01-30 2005-09-22 Ultrasound wound treatment method and device using standing waves

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/774,145 US6960173B2 (en) 2001-01-30 2001-01-30 Ultrasound wound treatment method and device using standing waves
US11/232,801 US20060058710A1 (en) 2001-01-30 2005-09-22 Ultrasound wound treatment method and device using standing waves

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/774,145 Continuation US6960173B2 (en) 2001-01-30 2001-01-30 Ultrasound wound treatment method and device using standing waves

Publications (1)

Publication Number Publication Date
US20060058710A1 true US20060058710A1 (en) 2006-03-16

Family

ID=25100369

Family Applications (2)

Application Number Title Priority Date Filing Date
US09/774,145 Expired - Lifetime US6960173B2 (en) 2001-01-30 2001-01-30 Ultrasound wound treatment method and device using standing waves
US11/232,801 Abandoned US20060058710A1 (en) 2001-01-30 2005-09-22 Ultrasound wound treatment method and device using standing waves

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US09/774,145 Expired - Lifetime US6960173B2 (en) 2001-01-30 2001-01-30 Ultrasound wound treatment method and device using standing waves

Country Status (8)

Country Link
US (2) US6960173B2 (en)
EP (1) EP1355696B1 (en)
JP (1) JP4164582B2 (en)
AT (1) ATE431175T1 (en)
AU (1) AU2002243732A1 (en)
CA (1) CA2436812A1 (en)
DE (1) DE60232304D1 (en)
WO (1) WO2002060525A2 (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030236560A1 (en) * 2001-01-12 2003-12-25 Eilaz Babaev Ultrasonic method and device for wound treatment
US20040186384A1 (en) * 2001-01-12 2004-09-23 Eilaz Babaev Ultrasonic method and device for wound treatment
US20060025716A1 (en) * 2000-10-06 2006-02-02 Eilaz Babaev Nozzle for ultrasound wound treatment
US20070016110A1 (en) * 2005-06-23 2007-01-18 Eilaz Babaev Removable applicator nozzle for ultrasound wound therapy device
US20070088245A1 (en) * 2005-06-23 2007-04-19 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US20080051693A1 (en) * 2006-08-25 2008-02-28 Bacoustics Llc Portable Ultrasound Device for the Treatment of Wounds
US20080128362A1 (en) * 2006-12-04 2008-06-05 Bacoustics Llc Method of ultrasonically treating a continuous flow of fluid
US20080177221A1 (en) * 2006-12-22 2008-07-24 Celleration, Inc. Apparatus to prevent applicator re-use
US20080214965A1 (en) * 2007-01-04 2008-09-04 Celleration, Inc. Removable multi-channel applicator nozzle
US20080243047A1 (en) * 2007-03-27 2008-10-02 Babaev Eilaz P Ultrasound wound care device
US20090043248A1 (en) * 2007-01-04 2009-02-12 Celleration, Inc. Removable multi-channel applicator nozzle
US20090177122A1 (en) * 2007-12-28 2009-07-09 Celleration, Inc. Methods for treating inflammatory skin disorders
US20090177123A1 (en) * 2007-12-28 2009-07-09 Celleration, Inc. Methods for treating inflammatory disorders
US20090200390A1 (en) * 2008-02-12 2009-08-13 Eilaz Babaev Ultrasound atomization system
US20090200396A1 (en) * 2008-02-11 2009-08-13 Eilaz Babaev Mechanical and ultrasound atomization and mixing system
US20100022919A1 (en) * 2008-07-22 2010-01-28 Celleration, Inc. Methods of Skin Grafting Using Ultrasound
US7842249B2 (en) 2006-03-29 2010-11-30 Bacoustics, Llc Apparatus for vaccine development using ultrasound technology
US8016208B2 (en) 2008-02-08 2011-09-13 Bacoustics, Llc Echoing ultrasound atomization and mixing system
USD733321S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment device
USD733319S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment wand
US11224767B2 (en) 2013-11-26 2022-01-18 Sanuwave Health, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7789841B2 (en) 1997-02-06 2010-09-07 Exogen, Inc. Method and apparatus for connective tissue treatment
US5904659A (en) * 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
JP2005304918A (en) * 2004-04-23 2005-11-04 Teijin Pharma Ltd Wound treatment device
JP2008500136A (en) * 2004-05-18 2008-01-10 ナノヴィブロニクス・インコーポレーテッド Nano-vibration coating process for medical devices using multiple vibration modes of thin piezo elements
AU2005205820B2 (en) * 2004-09-04 2011-04-14 Smith & Nephew Plc Ultrasound device and method of use
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US20070167824A1 (en) * 2005-11-30 2007-07-19 Warren Lee Method of manufacture of catheter tips, including mechanically scanning ultrasound probe catheter tip, and apparatus made by the method
US20070167825A1 (en) * 2005-11-30 2007-07-19 Warren Lee Apparatus for catheter tips, including mechanically scanning ultrasound probe catheter tip
US20070249938A1 (en) * 2006-04-20 2007-10-25 Donald J. Shields Systems, devices, and methods employing therapeutic ultrasound of living tissues
CA2654316C (en) * 2006-06-07 2015-04-07 Trinity Wound Institute, Llc Oxygen therapy with ultrasound
US20080097252A1 (en) * 2006-08-25 2008-04-24 Eilaz Babaev Ultrasound and Pressure Therapy Wound Care Device
US8430897B2 (en) 2006-08-29 2013-04-30 Misonix Incorporated Ultrasonic wound debrider probe and method of use
US7896854B2 (en) 2007-07-13 2011-03-01 Bacoustics, Llc Method of treating wounds by creating a therapeutic solution with ultrasonic waves
JP5869219B2 (en) 2007-08-16 2016-02-24 レメドー バイオメッド リミテッド Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications
US20090099485A1 (en) * 2007-10-16 2009-04-16 Sarvazyan Armen P Ultrasound standing wave method and apparatus for tissue treatment
JP2011509143A (en) * 2008-01-11 2011-03-24 ミソニクス インコーポレイテッド Ultrasonic wound excision probe and method of use thereof
US20090254005A1 (en) * 2008-04-03 2009-10-08 Eilaz Babaev Ultrasound assisted tissue welding device
US8465686B2 (en) 2008-12-19 2013-06-18 Volcano Corporation Method of manufacturing a rotational intravascular ultrasound probe
WO2012018390A2 (en) * 2010-08-02 2012-02-09 Guided Therapy Systems, Llc Systems and methods for treating acute and/or chronic injuries in soft tissue
US20150209564A1 (en) * 2011-09-02 2015-07-30 Drexel University Ultrasound device and therapeutic methods
JP6219835B2 (en) 2011-10-28 2017-10-25 ディスィジョン サイエンシズ インターナショナル コーポレーション Spread spectrum coded waveforms in ultrasound imaging
US9844359B2 (en) 2013-09-13 2017-12-19 Decision Sciences Medical Company, LLC Coherent spread-spectrum coded waveforms in synthetic aperture image formation
CN107635470B (en) 2015-02-25 2021-02-02 决策科学医疗有限责任公司 Acoustic signal transmission coupling and coupling medium
AU2016314611C1 (en) 2015-09-04 2019-12-19 Remedor Biomed Ltd. Topical erythropoietin formulations and methods for improving wound healing with and cosmetic use of the formulations
WO2017062890A1 (en) 2015-10-08 2017-04-13 Decision Sciences Medical Company, LLC Acoustic orthopedic tracking system and methods
AU2017302612A1 (en) * 2016-07-29 2019-03-14 Alliqua Biomedical, Inc. Systems and methods for delivering cellular and biological materials using ultrasound for wound treatment and healing
CN111405927A (en) * 2017-09-29 2020-07-10 学校法人日本医科大学 Ultrasonic treatment device
CN110404187B (en) * 2018-04-28 2022-03-01 重庆海扶医疗科技股份有限公司 Method for generating ultrahigh sound pressure and ultrahigh sound pressure generating device
US12017389B2 (en) 2019-03-06 2024-06-25 Decision Sciences Medical Company, LLC Methods for manufacturing and distributing semi-rigid acoustic coupling articles and packaging for ultrasound imaging
US11154274B2 (en) 2019-04-23 2021-10-26 Decision Sciences Medical Company, LLC Semi-rigid acoustic coupling articles for ultrasound diagnostic and treatment applications
US11980383B2 (en) 2019-12-24 2024-05-14 Farrow Medtech Llc Wound-care apparatus and method for cleansing, desloughing, and debriding wounds
EP4243696A4 (en) 2020-11-13 2024-09-04 Decision Sciences Medical Company Llc Systems and methods for synthetic aperture ultrasound imaging of an object

Citations (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3392916A (en) * 1965-12-08 1968-07-16 Carl Gunnar Daniel Engstrom Ultrasonic atomizer
US3561444A (en) * 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3860173A (en) * 1970-02-03 1975-01-14 Naoyasu Sata Non-polluting combustion engine having ultrasonic fuel atomizer in place of carburetor
US4085893A (en) * 1974-03-20 1978-04-25 Durley Iii Benton A Ultrasonic humidifiers, atomizers and the like
US4153201A (en) * 1976-11-08 1979-05-08 Sono-Tek Corporation Transducer assembly, ultrasonic atomizer and fuel burner
US4215031A (en) * 1979-02-14 1980-07-29 Nalco Chemical Company Thickening additives for unsaturated polyester resins
US4271705A (en) * 1978-06-30 1981-06-09 Karl Deutsch Pruf-und Messgerate Method and device for generating acoustic pulses
US4309989A (en) * 1976-02-09 1982-01-12 The Curators Of The University Of Missouri Topical application of medication by ultrasound with coupling agent
US4319155A (en) * 1979-01-09 1982-03-09 Omron Tateisi Electronics Co. Nebulization control system for a piezoelectric ultrasonic nebulizer
US4334531A (en) * 1979-06-19 1982-06-15 Bosch-Siemens Hausgerate Gmbh Inhalator
US4428531A (en) * 1979-09-11 1984-01-31 Eaton Corporation Method of producing a fuel injector
US4466571A (en) * 1981-06-24 1984-08-21 Muehlbauer Reinhard High-pressure liquid injection system
US4530360A (en) * 1981-11-19 1985-07-23 Duarte Luiz R Method for healing bone fractures with ultrasound
US4582654A (en) * 1984-09-12 1986-04-15 Varian Associates, Inc. Nebulizer particularly adapted for analytical purposes
US4642581A (en) * 1985-06-21 1987-02-10 Sono-Tek Corporation Ultrasonic transducer drive circuit
US4655393A (en) * 1983-01-05 1987-04-07 Sonotek Corporation High volume ultrasonic liquid atomizer
US4659014A (en) * 1985-09-05 1987-04-21 Delavan Corporation Ultrasonic spray nozzle and method
US4679551A (en) * 1984-02-23 1987-07-14 Tomtec, N.V. Device for performing therapeutic treatments
US4726523A (en) * 1984-12-11 1988-02-23 Toa Nenryo Kogyo Kabushiki Kaisha Ultrasonic injection nozzle
US4726525A (en) * 1985-05-13 1988-02-23 Toa Nenryo Kogyo Kabushiki Kaisha Vibrating element for ultrasonic injection
US4733820A (en) * 1984-12-11 1988-03-29 Toa Nenryo Kogyo Kabushiki Kaisha Vibrating element for use on an ultrasonic injection nozzle
US4756478A (en) * 1984-12-11 1988-07-12 Toa Nenryo Kogyo Kabushiki Kaisha Vibrating element for use on an ultrasonic injection nozzle
US4818697A (en) * 1986-10-27 1989-04-04 Life Resonances, Inc. Techniques for enhancing the permeability of ions through membranes
US4850534A (en) * 1987-05-30 1989-07-25 Tdk Corporation Ultrasonic wave nebulizer
US4905671A (en) * 1988-01-11 1990-03-06 Dornier Medizintechnik Gmbh Inducement of bone growth by acoustic shock waves
US4930700A (en) * 1986-08-27 1990-06-05 Atochem North America Ultrasonic dispersion nozzle having internal shut-off mechanism with barrier fluid separation
US4941618A (en) * 1986-07-07 1990-07-17 Leeman Labs Inc. Nebulizer employing a fine mesh screen
US5002059A (en) * 1989-07-26 1991-03-26 Boston Scientific Corporation Tip filled ultrasound catheter
US5040537A (en) * 1987-11-24 1991-08-20 Hitachi, Ltd. Method and apparatus for the measurement and medical treatment using an ultrasonic wave
US5104042A (en) * 1986-08-27 1992-04-14 Atochem North America, Inc. Ultrasonic dispersion nozzle with internal shut-off mechanism having barrier-fluid separation means incorporated therewith
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5134993A (en) * 1988-12-13 1992-08-04 Siemens Aktiengesellschaft Inhalator device, in particular a pocket inhalator
US5186162A (en) * 1988-09-14 1993-02-16 Interpore Orthopaedics, Inc. Ultrasonic transducer device for treatment of living tissue and/or cells
US5197946A (en) * 1990-06-27 1993-03-30 Shunro Tachibana Injection instrument with ultrasonic oscillating element
US5211160A (en) * 1988-09-14 1993-05-18 Interpore Orthopaedics, Inc. Ultrasonic orthopedic treatment head and body-mounting means therefor
US5231975A (en) * 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5309898A (en) * 1992-07-30 1994-05-10 Kaufman Jonathan J Ultrasonic bone-therapy and assessment apparatus and method
US5315998A (en) * 1991-03-22 1994-05-31 Katsuro Tachibana Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same
US5316000A (en) * 1991-03-05 1994-05-31 Technomed International (Societe Anonyme) Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy
US5318014A (en) * 1992-09-14 1994-06-07 Coraje, Inc. Ultrasonic ablation/dissolution transducer
US5324255A (en) * 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5380411A (en) * 1987-12-02 1995-01-10 Schering Aktiengesellschaft Ultrasound or shock wave work process and preparation for carrying out same
US5393296A (en) * 1992-12-09 1995-02-28 Siemens Aktiengesellschaft Method for the medical treatment of pathologic bone
US5431663A (en) * 1990-12-10 1995-07-11 Coraje, Inc. Miniature ultrasonic transducer for removal of intravascular plaque and clots
US5437606A (en) * 1994-03-28 1995-08-01 Tsukamoto; Kenichi Ultrasonic system to alleviate toothaches
US5516043A (en) * 1994-06-30 1996-05-14 Misonix Inc. Ultrasonic atomizing device
US5515841A (en) * 1993-11-25 1996-05-14 Minnesota Mining And Manufacturing Company Inhaler
US5520612A (en) * 1994-12-30 1996-05-28 Exogen, Inc. Acoustic system for bone-fracture therapy
US5520166A (en) * 1991-03-05 1996-05-28 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery system
US5527350A (en) * 1993-02-24 1996-06-18 Star Medical Technologies, Inc. Pulsed infrared laser treatment of psoriasis
US5529572A (en) * 1992-01-24 1996-06-25 Medispec Ltd. Method and apparatus particularly useful for treating osteoporosis
US5545172A (en) * 1994-06-07 1996-08-13 Malvern Technologies, Inc. Rocking foot plate for surgical knife
US5547459A (en) * 1994-10-25 1996-08-20 Orthologic Corporation Ultrasonic bone-therapy apparatus and method
US5616140A (en) * 1994-03-21 1997-04-01 Prescott; Marvin Method and apparatus for therapeutic laser treatment
US5626554A (en) * 1995-02-21 1997-05-06 Exogen, Inc. Gel containment structure
US5643179A (en) * 1993-12-28 1997-07-01 Kabushiki Kaisha Toshiba Method and apparatus for ultrasonic medical treatment with optimum ultrasonic irradiation control
US5656016A (en) * 1996-03-18 1997-08-12 Abbott Laboratories Sonophoretic drug delivery system
US5658323A (en) * 1995-07-12 1997-08-19 Miller; Iain D. Method and apparatus for dermatology treatment
US5707403A (en) * 1993-02-24 1998-01-13 Star Medical Technologies, Inc. Method for the laser treatment of subsurface blood vessels
US5707402A (en) * 1995-05-09 1998-01-13 Team Medical, L.L.C. Directed energy surgical method and assembly
US5730705A (en) * 1995-06-12 1998-03-24 Talish; Roger J. Ultrasonic treatment for bony ingrowth
US5735811A (en) * 1995-11-30 1998-04-07 Pharmasonics, Inc. Apparatus and methods for ultrasonically enhanced fluid delivery
US5743863A (en) * 1993-01-22 1998-04-28 Technomed Medical Systems And Institut National High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes
US5762616A (en) * 1996-03-15 1998-06-09 Exogen, Inc. Apparatus for ultrasonic treatment of sites corresponding to the torso
US5785972A (en) * 1997-01-10 1998-07-28 Tyler; Kathleen A. Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application
US5879314A (en) * 1997-06-30 1999-03-09 Cybersonics, Inc. Transducer assembly and method for coupling ultrasonic energy to a body for thrombolysis of vascular thrombi
US5879364A (en) * 1996-06-03 1999-03-09 Ethicon Endo-Surgery, Inc. Internal ultrasonic tip amplifier
US5882302A (en) * 1992-02-21 1999-03-16 Ths International, Inc. Methods and devices for providing acoustic hemostasis
US5894841A (en) * 1993-06-29 1999-04-20 Ponwell Enterprises Limited Dispenser
US5895362A (en) * 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
US5904659A (en) * 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
US6014970A (en) * 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6024718A (en) * 1996-09-04 2000-02-15 The Regents Of The University Of California Intraluminal directed ultrasound delivery device
US6027495A (en) * 1995-07-12 2000-02-22 Esc Medical Systems Ltd. Method and apparatus for dermatology treatment
US6026808A (en) * 1997-10-17 2000-02-22 Sheffield Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US6036661A (en) * 1997-05-02 2000-03-14 Hmt Holding Ag Apparatus for administering acoustic shock waves
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US6061597A (en) * 1998-12-18 2000-05-09 Robert D. Rieman Method and device for healing bone fractures
US6076519A (en) * 1993-12-14 2000-06-20 Ethex International, Inc. Passive inspiratory nebulizer system
US6098620A (en) * 1993-01-29 2000-08-08 Aradigm Corporation Device for aerosolizing narcotics
US6104952A (en) * 1998-01-07 2000-08-15 Tu; Lily Chen Devices for treating canker sores, tissues and methods thereof
US6102298A (en) * 1998-02-23 2000-08-15 The Procter & Gamble Company Ultrasonic spray coating application system
US6106547A (en) * 1998-09-22 2000-08-22 Huei-Jung; Lien Hot/cold dual-mold skin treatment apparatus
US6176839B1 (en) * 1997-08-04 2001-01-23 Hmt High Medical Technologies Ag Method and system for treatment with acoustic shock waves
US6186963B1 (en) * 1997-05-02 2001-02-13 Hmt Holding Ag Device for generating acoustic shock waves, especially for medical applications
US6190315B1 (en) * 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US6206843B1 (en) * 1999-01-28 2001-03-27 Ultra Cure Ltd. Ultrasound system and methods utilizing same
US6206842B1 (en) * 1998-08-03 2001-03-27 Lily Chen Tu Ultrasonic operation device
US6231528B1 (en) * 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
US6234990B1 (en) * 1996-06-28 2001-05-22 Sontra Medical, Inc. Ultrasound enhancement of transdermal transport
US6251099B1 (en) * 1996-11-27 2001-06-26 The General Hospital Corporation Compound delivery using impulse transients
US6569099B1 (en) * 2001-01-12 2003-05-27 Eilaz Babaev Ultrasonic method and device for wound treatment
US6732744B2 (en) * 2001-12-07 2004-05-11 The Procter & Gamble Company Method for the ultrasonic treatment of hair and other keratinous fibers
US7316664B2 (en) * 2002-10-21 2008-01-08 Advanced Medical Optics, Inc. Modulated pulsed ultrasonic power delivery system and method

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275059A (en) * 1965-05-10 1966-09-27 Little Inc A Nozzle system and fuel oil burner incorporating it
GB1496086A (en) 1975-02-19 1977-12-21 Plessey Co Ltd Vibratory atomizer
US4301968A (en) 1976-11-08 1981-11-24 Sono-Tek Corporation Transducer assembly, ultrasonic atomizer and fuel burner
DE2811248C3 (en) 1978-03-15 1981-11-26 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Liquid atomizer
GB2029270B (en) * 1978-07-11 1982-11-03 Plessey Co Ltd Vibratory atomiser
DE2854841C2 (en) 1978-12-19 1981-03-26 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Liquid atomizer, preferably inhalation device
US4352459A (en) 1979-11-13 1982-10-05 Sono-Tek Corporation Ultrasonic liquid atomizer having an axially-extending liquid feed passage
US4541564A (en) * 1983-01-05 1985-09-17 Sono-Tek Corporation Ultrasonic liquid atomizer, particularly for high volume flow rates
GB8316051D0 (en) 1983-06-13 1983-07-20 Shell Int Research Atomiser
JPS60222552A (en) 1984-04-19 1985-11-07 Toa Nenryo Kogyo Kk Ultrasonic injection method and injection valve
EP0173334B1 (en) 1984-08-29 1989-11-23 Omron Tateisi Electronics Co. Ultrasonic atomizer
DE3582287D1 (en) 1984-09-07 1991-05-02 Omron Tateisi Electronics Co VIBRATION GENERATOR FOR AN INHALATION DEVICE WITH ULTRASONIC SPRAYING.
DE3627222A1 (en) 1986-08-11 1988-02-18 Siemens Ag ULTRASONIC POCKET SPRAYER
FI82808C (en) 1987-12-31 1991-04-25 Etelae Haemeen Keuhkovammayhdi Ultraljudfinfördelningsanordning
WO1990012655A1 (en) 1989-04-14 1990-11-01 Azerbaidzhansky Politekhnichesky Institut Imeni Ch.Ildryma Device for ultrasonic dispersion of a liquid medium
DE3915384C2 (en) * 1989-05-11 1994-05-11 Dornier Medizintechnik Location kinematics for a lithotripter
US5163433A (en) 1989-11-01 1992-11-17 Olympus Optical Co., Ltd. Ultrasound type treatment apparatus
US4961885A (en) 1989-11-24 1990-10-09 Elecsys Ltd. Ultrasonic nebulizer
JPH0417844A (en) * 1990-05-10 1992-01-22 Olympus Optical Co Ltd Dissolving therapy apparatus
GB9015077D0 (en) * 1990-07-09 1990-08-29 Riker Laboratories Inc Inhaler
US5172692A (en) 1990-12-05 1992-12-22 Kulow Howard H Method for inflammatory response management
US5325860A (en) * 1991-11-08 1994-07-05 Mayo Foundation For Medical Education And Research Ultrasonic and interventional catheter and method
GB2265845B (en) * 1991-11-12 1996-05-01 Medix Ltd A nebuliser and nebuliser control system
US5374266A (en) 1991-11-27 1994-12-20 Kabushiki Kaisha Morita Seisakusho Medical laser treatment device
US5362309A (en) 1992-09-14 1994-11-08 Coraje, Inc. Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis
US5523058A (en) * 1992-09-16 1996-06-04 Hitachi, Ltd. Ultrasonic irradiation apparatus and processing apparatus based thereon
DE4315282C2 (en) * 1993-05-07 1999-10-07 Siemens Ag Use of an acoustic pressure pulse source
CH686872A5 (en) * 1993-08-09 1996-07-31 Disetronic Ag Medical Inhalationsgeraet.
US5556372A (en) 1995-02-15 1996-09-17 Exogen, Inc. Apparatus for ultrasonic bone treatment
US5947921A (en) 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
JPH09135908A (en) * 1995-11-17 1997-05-27 Aloka Co Ltd Ultrasonic diagnosis treatment system
US5683432A (en) 1996-01-11 1997-11-04 Medtronic, Inc. Adaptive, performance-optimizing communication system for communicating with an implanted medical device
US5664570A (en) * 1996-02-20 1997-09-09 Svc Apparatus for applying high-intensity ultrasonic waves to a target volume within a human or animal body
US5699805A (en) 1996-06-20 1997-12-23 Mayo Foundation For Medical Education And Research Longitudinal multiplane ultrasound transducer underfluid catheter system
US5835678A (en) 1996-10-03 1998-11-10 Emcore Corporation Liquid vaporizer system and method
US6007499A (en) * 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
US6314318B1 (en) * 2000-01-20 2001-11-06 Norman C. Petty Device and method for treating infection using standing radio frequency waves
US6761729B2 (en) * 2000-12-22 2004-07-13 Advanced Medicalapplications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6533803B2 (en) * 2000-12-22 2003-03-18 Advanced Medical Applications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6478754B1 (en) * 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3392916A (en) * 1965-12-08 1968-07-16 Carl Gunnar Daniel Engstrom Ultrasonic atomizer
US3561444A (en) * 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3860173A (en) * 1970-02-03 1975-01-14 Naoyasu Sata Non-polluting combustion engine having ultrasonic fuel atomizer in place of carburetor
US4085893A (en) * 1974-03-20 1978-04-25 Durley Iii Benton A Ultrasonic humidifiers, atomizers and the like
US4309989A (en) * 1976-02-09 1982-01-12 The Curators Of The University Of Missouri Topical application of medication by ultrasound with coupling agent
US4153201A (en) * 1976-11-08 1979-05-08 Sono-Tek Corporation Transducer assembly, ultrasonic atomizer and fuel burner
US4271705A (en) * 1978-06-30 1981-06-09 Karl Deutsch Pruf-und Messgerate Method and device for generating acoustic pulses
US4319155A (en) * 1979-01-09 1982-03-09 Omron Tateisi Electronics Co. Nebulization control system for a piezoelectric ultrasonic nebulizer
US4215031A (en) * 1979-02-14 1980-07-29 Nalco Chemical Company Thickening additives for unsaturated polyester resins
US4334531A (en) * 1979-06-19 1982-06-15 Bosch-Siemens Hausgerate Gmbh Inhalator
US4428531A (en) * 1979-09-11 1984-01-31 Eaton Corporation Method of producing a fuel injector
US4466571A (en) * 1981-06-24 1984-08-21 Muehlbauer Reinhard High-pressure liquid injection system
US4530360A (en) * 1981-11-19 1985-07-23 Duarte Luiz R Method for healing bone fractures with ultrasound
US4655393A (en) * 1983-01-05 1987-04-07 Sonotek Corporation High volume ultrasonic liquid atomizer
US4679551A (en) * 1984-02-23 1987-07-14 Tomtec, N.V. Device for performing therapeutic treatments
US4582654A (en) * 1984-09-12 1986-04-15 Varian Associates, Inc. Nebulizer particularly adapted for analytical purposes
US4726523A (en) * 1984-12-11 1988-02-23 Toa Nenryo Kogyo Kabushiki Kaisha Ultrasonic injection nozzle
US4733820A (en) * 1984-12-11 1988-03-29 Toa Nenryo Kogyo Kabushiki Kaisha Vibrating element for use on an ultrasonic injection nozzle
US4756478A (en) * 1984-12-11 1988-07-12 Toa Nenryo Kogyo Kabushiki Kaisha Vibrating element for use on an ultrasonic injection nozzle
US4726525A (en) * 1985-05-13 1988-02-23 Toa Nenryo Kogyo Kabushiki Kaisha Vibrating element for ultrasonic injection
US4642581A (en) * 1985-06-21 1987-02-10 Sono-Tek Corporation Ultrasonic transducer drive circuit
US4659014A (en) * 1985-09-05 1987-04-21 Delavan Corporation Ultrasonic spray nozzle and method
US4941618A (en) * 1986-07-07 1990-07-17 Leeman Labs Inc. Nebulizer employing a fine mesh screen
US4930700A (en) * 1986-08-27 1990-06-05 Atochem North America Ultrasonic dispersion nozzle having internal shut-off mechanism with barrier fluid separation
US5104042A (en) * 1986-08-27 1992-04-14 Atochem North America, Inc. Ultrasonic dispersion nozzle with internal shut-off mechanism having barrier-fluid separation means incorporated therewith
US4818697A (en) * 1986-10-27 1989-04-04 Life Resonances, Inc. Techniques for enhancing the permeability of ions through membranes
US4850534A (en) * 1987-05-30 1989-07-25 Tdk Corporation Ultrasonic wave nebulizer
US5040537A (en) * 1987-11-24 1991-08-20 Hitachi, Ltd. Method and apparatus for the measurement and medical treatment using an ultrasonic wave
US5380411A (en) * 1987-12-02 1995-01-10 Schering Aktiengesellschaft Ultrasound or shock wave work process and preparation for carrying out same
US4905671A (en) * 1988-01-11 1990-03-06 Dornier Medizintechnik Gmbh Inducement of bone growth by acoustic shock waves
US5186162A (en) * 1988-09-14 1993-02-16 Interpore Orthopaedics, Inc. Ultrasonic transducer device for treatment of living tissue and/or cells
US5211160A (en) * 1988-09-14 1993-05-18 Interpore Orthopaedics, Inc. Ultrasonic orthopedic treatment head and body-mounting means therefor
US5134993A (en) * 1988-12-13 1992-08-04 Siemens Aktiengesellschaft Inhalator device, in particular a pocket inhalator
US5002059A (en) * 1989-07-26 1991-03-26 Boston Scientific Corporation Tip filled ultrasound catheter
US5231975A (en) * 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5323769A (en) * 1990-02-23 1994-06-28 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5197946A (en) * 1990-06-27 1993-03-30 Shunro Tachibana Injection instrument with ultrasonic oscillating element
US5431663A (en) * 1990-12-10 1995-07-11 Coraje, Inc. Miniature ultrasonic transducer for removal of intravascular plaque and clots
US5324255A (en) * 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5316000A (en) * 1991-03-05 1994-05-31 Technomed International (Societe Anonyme) Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy
US5520166A (en) * 1991-03-05 1996-05-28 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery system
US5315998A (en) * 1991-03-22 1994-05-31 Katsuro Tachibana Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same
US5529572A (en) * 1992-01-24 1996-06-25 Medispec Ltd. Method and apparatus particularly useful for treating osteoporosis
US5882302A (en) * 1992-02-21 1999-03-16 Ths International, Inc. Methods and devices for providing acoustic hemostasis
US5309898A (en) * 1992-07-30 1994-05-10 Kaufman Jonathan J Ultrasonic bone-therapy and assessment apparatus and method
US5318014A (en) * 1992-09-14 1994-06-07 Coraje, Inc. Ultrasonic ablation/dissolution transducer
US5393296A (en) * 1992-12-09 1995-02-28 Siemens Aktiengesellschaft Method for the medical treatment of pathologic bone
US5743863A (en) * 1993-01-22 1998-04-28 Technomed Medical Systems And Institut National High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes
US6098620A (en) * 1993-01-29 2000-08-08 Aradigm Corporation Device for aerosolizing narcotics
US5707403A (en) * 1993-02-24 1998-01-13 Star Medical Technologies, Inc. Method for the laser treatment of subsurface blood vessels
US5527350A (en) * 1993-02-24 1996-06-18 Star Medical Technologies, Inc. Pulsed infrared laser treatment of psoriasis
US5894841A (en) * 1993-06-29 1999-04-20 Ponwell Enterprises Limited Dispenser
US5515841A (en) * 1993-11-25 1996-05-14 Minnesota Mining And Manufacturing Company Inhaler
US6076519A (en) * 1993-12-14 2000-06-20 Ethex International, Inc. Passive inspiratory nebulizer system
US5643179A (en) * 1993-12-28 1997-07-01 Kabushiki Kaisha Toshiba Method and apparatus for ultrasonic medical treatment with optimum ultrasonic irradiation control
US5616140A (en) * 1994-03-21 1997-04-01 Prescott; Marvin Method and apparatus for therapeutic laser treatment
US5437606A (en) * 1994-03-28 1995-08-01 Tsukamoto; Kenichi Ultrasonic system to alleviate toothaches
US5545172A (en) * 1994-06-07 1996-08-13 Malvern Technologies, Inc. Rocking foot plate for surgical knife
US5516043A (en) * 1994-06-30 1996-05-14 Misonix Inc. Ultrasonic atomizing device
US5547459A (en) * 1994-10-25 1996-08-20 Orthologic Corporation Ultrasonic bone-therapy apparatus and method
US5752924A (en) * 1994-10-25 1998-05-19 Orthologic Corporation Ultrasonic bone-therapy apparatus and method
US5520612A (en) * 1994-12-30 1996-05-28 Exogen, Inc. Acoustic system for bone-fracture therapy
US5626554A (en) * 1995-02-21 1997-05-06 Exogen, Inc. Gel containment structure
US5707402A (en) * 1995-05-09 1998-01-13 Team Medical, L.L.C. Directed energy surgical method and assembly
US6083159A (en) * 1995-05-22 2000-07-04 Ths International, Inc. Methods and devices for providing acoustic hemostasis
US5730705A (en) * 1995-06-12 1998-03-24 Talish; Roger J. Ultrasonic treatment for bony ingrowth
US6027495A (en) * 1995-07-12 2000-02-22 Esc Medical Systems Ltd. Method and apparatus for dermatology treatment
US5658323A (en) * 1995-07-12 1997-08-19 Miller; Iain D. Method and apparatus for dermatology treatment
US5735811A (en) * 1995-11-30 1998-04-07 Pharmasonics, Inc. Apparatus and methods for ultrasonically enhanced fluid delivery
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5895362A (en) * 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
US5762616A (en) * 1996-03-15 1998-06-09 Exogen, Inc. Apparatus for ultrasonic treatment of sites corresponding to the torso
US5656016A (en) * 1996-03-18 1997-08-12 Abbott Laboratories Sonophoretic drug delivery system
US5879364A (en) * 1996-06-03 1999-03-09 Ethicon Endo-Surgery, Inc. Internal ultrasonic tip amplifier
US6234990B1 (en) * 1996-06-28 2001-05-22 Sontra Medical, Inc. Ultrasound enhancement of transdermal transport
US6024718A (en) * 1996-09-04 2000-02-15 The Regents Of The University Of California Intraluminal directed ultrasound delivery device
US6251099B1 (en) * 1996-11-27 2001-06-26 The General Hospital Corporation Compound delivery using impulse transients
US5785972A (en) * 1997-01-10 1998-07-28 Tyler; Kathleen A. Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application
US6190336B1 (en) * 1997-02-14 2001-02-20 Exogen, Inc. Ultrasonic treatment for wounds
US5904659A (en) * 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
US6036661A (en) * 1997-05-02 2000-03-14 Hmt Holding Ag Apparatus for administering acoustic shock waves
US6186963B1 (en) * 1997-05-02 2001-02-13 Hmt Holding Ag Device for generating acoustic shock waves, especially for medical applications
US5879314A (en) * 1997-06-30 1999-03-09 Cybersonics, Inc. Transducer assembly and method for coupling ultrasonic energy to a body for thrombolysis of vascular thrombi
US6176839B1 (en) * 1997-08-04 2001-01-23 Hmt High Medical Technologies Ag Method and system for treatment with acoustic shock waves
US6026808A (en) * 1997-10-17 2000-02-22 Sheffield Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US6095141A (en) * 1997-10-17 2000-08-01 Sheffield Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US6104952A (en) * 1998-01-07 2000-08-15 Tu; Lily Chen Devices for treating canker sores, tissues and methods thereof
US6190315B1 (en) * 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US6102298A (en) * 1998-02-23 2000-08-15 The Procter & Gamble Company Ultrasonic spray coating application system
US6014970A (en) * 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6206842B1 (en) * 1998-08-03 2001-03-27 Lily Chen Tu Ultrasonic operation device
US6106547A (en) * 1998-09-22 2000-08-22 Huei-Jung; Lien Hot/cold dual-mold skin treatment apparatus
US6061597A (en) * 1998-12-18 2000-05-09 Robert D. Rieman Method and device for healing bone fractures
US6231528B1 (en) * 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
US6206843B1 (en) * 1999-01-28 2001-03-27 Ultra Cure Ltd. Ultrasound system and methods utilizing same
US6569099B1 (en) * 2001-01-12 2003-05-27 Eilaz Babaev Ultrasonic method and device for wound treatment
US6732744B2 (en) * 2001-12-07 2004-05-11 The Procter & Gamble Company Method for the ultrasonic treatment of hair and other keratinous fibers
US7316664B2 (en) * 2002-10-21 2008-01-08 Advanced Medical Optics, Inc. Modulated pulsed ultrasonic power delivery system and method

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025716A1 (en) * 2000-10-06 2006-02-02 Eilaz Babaev Nozzle for ultrasound wound treatment
US20090024076A1 (en) * 2000-10-06 2009-01-22 Celleration, Inc. Nozzle for ultrasound wound treatment
US20030236560A1 (en) * 2001-01-12 2003-12-25 Eilaz Babaev Ultrasonic method and device for wound treatment
US20040186384A1 (en) * 2001-01-12 2004-09-23 Eilaz Babaev Ultrasonic method and device for wound treatment
US7914470B2 (en) 2001-01-12 2011-03-29 Celleration, Inc. Ultrasonic method and device for wound treatment
US20110230795A1 (en) * 2001-01-12 2011-09-22 Eilaz Babaev Ultrasonic method and device for wound treatment
US8235919B2 (en) 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US20070088245A1 (en) * 2005-06-23 2007-04-19 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7785277B2 (en) 2005-06-23 2010-08-31 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US20070016110A1 (en) * 2005-06-23 2007-01-18 Eilaz Babaev Removable applicator nozzle for ultrasound wound therapy device
US7713218B2 (en) 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7943352B2 (en) 2006-03-29 2011-05-17 Bacoustics, Llc Apparatus and methods for vaccine development using ultrasound technology
US7842249B2 (en) 2006-03-29 2010-11-30 Bacoustics, Llc Apparatus for vaccine development using ultrasound technology
US20080051693A1 (en) * 2006-08-25 2008-02-28 Bacoustics Llc Portable Ultrasound Device for the Treatment of Wounds
US7878991B2 (en) 2006-08-25 2011-02-01 Bacoustics, Llc Portable ultrasound device for the treatment of wounds
US20080128362A1 (en) * 2006-12-04 2008-06-05 Bacoustics Llc Method of ultrasonically treating a continuous flow of fluid
US7846341B2 (en) 2006-12-04 2010-12-07 Bacoustics, Llc Method of ultrasonically treating a continuous flow of fluid
US20080177221A1 (en) * 2006-12-22 2008-07-24 Celleration, Inc. Apparatus to prevent applicator re-use
US20080214965A1 (en) * 2007-01-04 2008-09-04 Celleration, Inc. Removable multi-channel applicator nozzle
US8491521B2 (en) 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
US20090043248A1 (en) * 2007-01-04 2009-02-12 Celleration, Inc. Removable multi-channel applicator nozzle
US20080243047A1 (en) * 2007-03-27 2008-10-02 Babaev Eilaz P Ultrasound wound care device
US20090177123A1 (en) * 2007-12-28 2009-07-09 Celleration, Inc. Methods for treating inflammatory disorders
US20090177122A1 (en) * 2007-12-28 2009-07-09 Celleration, Inc. Methods for treating inflammatory skin disorders
US8016208B2 (en) 2008-02-08 2011-09-13 Bacoustics, Llc Echoing ultrasound atomization and mixing system
US7950594B2 (en) 2008-02-11 2011-05-31 Bacoustics, Llc Mechanical and ultrasound atomization and mixing system
US20090200396A1 (en) * 2008-02-11 2009-08-13 Eilaz Babaev Mechanical and ultrasound atomization and mixing system
US7830070B2 (en) 2008-02-12 2010-11-09 Bacoustics, Llc Ultrasound atomization system
US20090200390A1 (en) * 2008-02-12 2009-08-13 Eilaz Babaev Ultrasound atomization system
US20100022919A1 (en) * 2008-07-22 2010-01-28 Celleration, Inc. Methods of Skin Grafting Using Ultrasound
US11224767B2 (en) 2013-11-26 2022-01-18 Sanuwave Health, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
US11331520B2 (en) 2013-11-26 2022-05-17 Sanuwave Health, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
USD733321S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment device
USD733319S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment wand

Also Published As

Publication number Publication date
AU2002243732A1 (en) 2002-08-12
US6960173B2 (en) 2005-11-01
WO2002060525A2 (en) 2002-08-08
EP1355696B1 (en) 2009-05-13
EP1355696A4 (en) 2006-05-31
ATE431175T1 (en) 2009-05-15
DE60232304D1 (en) 2009-06-25
US20020103448A1 (en) 2002-08-01
JP2004538039A (en) 2004-12-24
JP4164582B2 (en) 2008-10-15
EP1355696A2 (en) 2003-10-29
CA2436812A1 (en) 2002-08-08
WO2002060525A3 (en) 2003-03-20

Similar Documents

Publication Publication Date Title
US6960173B2 (en) Ultrasound wound treatment method and device using standing waves
US6761729B2 (en) Wound treatment method and device with combination of ultrasound and laser energy
US6533803B2 (en) Wound treatment method and device with combination of ultrasound and laser energy
US6569099B1 (en) Ultrasonic method and device for wound treatment
US6478754B1 (en) Ultrasonic method and device for wound treatment
CA2521117C (en) Ultrasnoic method and device for wound treatment
US8235919B2 (en) Ultrasonic method and device for wound treatment
US7572268B2 (en) Apparatus and methods for the selective removal of tissue using combinations of ultrasonic energy and cryogenic energy
US7713218B2 (en) Removable applicator nozzle for ultrasound wound therapy device
KR102335095B1 (en) Rapid pulse electrohydraulic shockwave generator
EP1322275B1 (en) Ultrasonic method and device for wound treatment
RU2393881C1 (en) Device for ultrasound irrigation of biotissues with drugs

Legal Events

Date Code Title Description
AS Assignment

Owner name: CELLERATION, INC., MINNESOTA

Free format text: CHANGE OF NAME;ASSIGNOR:ADVANCED MEDICAL APPLICATIONS, INC.;REEL/FRAME:019102/0655

Effective date: 20020730

Owner name: CELLERATION, INC., MINNESOTA

Free format text: MERGER;ASSIGNOR:CELLERATION, INC.;REEL/FRAME:019094/0591

Effective date: 20030506

AS Assignment

Owner name: ADVANCED MEDICAL APPLICATIONS, INC., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BABAEV, EILAZ;REEL/FRAME:020474/0061

Effective date: 20011031

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION