US20110230795A1 - Ultrasonic method and device for wound treatment - Google Patents
Ultrasonic method and device for wound treatment Download PDFInfo
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- US20110230795A1 US20110230795A1 US13/073,863 US201113073863A US2011230795A1 US 20110230795 A1 US20110230795 A1 US 20110230795A1 US 201113073863 A US201113073863 A US 201113073863A US 2011230795 A1 US2011230795 A1 US 2011230795A1
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- wound
- ultrasonic energy
- tissue
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- radiation surface
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M3/00—Medical syringes, e.g. enemata; Irrigators
- A61M3/02—Enemata; Irrigators
- A61M3/0275—Pulsating jets; Vibrating nozzles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
Definitions
- the present invention relates to methods of using ultrasonic waves in wound treatment. More particularly, the present invention relates to a method of applying a medicament to tissue and delivering ultrasound energy to the medicament and the tissue.
- Ultrasonic waves have been widely used in medical applications, including for both diagnostics and therapy as well as for many industrial applications.
- One diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or a human tissue.
- an ultrasonic transducer is placed in contact with the object or tissue via a coupling medium, and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue.
- the waves are reflected back to a receiver adjacent the transducer.
- an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors, and the like.
- Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drugs to the lungs.
- Ultrasonic nebulizers operate by the passage of ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid at a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound energy. This technique can produce a very fine dense fog or mist.
- Aerosol mists produced by ultrasound are preferred over aerosol mists produced by other methods because a smaller particle size of aerosol can be obtained with the ultrasonic waves.
- One of the major shortcoming of inhalers and nebulizers is that the aerosol mist cannot be directed to a target area without an air stream, which decreases the efficiency of the ultrasound energy.
- Ultrasonic sprayers such as those sold by Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc. (see, for example, U.S. Pat. Nos. 4,153,201, 4,655,393, and 5,516,043) operate by passing liquid through a central orifice of an ultrasound instrument-tip.
- Major disadvantages of these sprayers include non-uniform particle size, heating of liquid flow, and less efficiency of ultrasound waves because of a demolished end (radiation) surface configuration of the tip.
- the coupling medium is typically a bath of liquid, a jelly applied to the surface to be treated, or a water-filled balloon.
- Conventional techniques provide ultrasonic waves having an intensity of about 0.1 w/cm 2 to 3 w/cm 2 at a frequency of about 0.8 to 3 Megahertz.
- the treatment is applied to a skin surface for from about 1 to 30 minutes, two or three times a week.
- the coupling medium can provide a cooling effect which dissipates some of the energy produced by the ultrasonic transducer.
- a coupling medium or direct contact between the tissue and ultrasonic transducer is necessary to transmit the ultrasonic waves to the skin surface because ambient air is a relatively poor medium for the propagation of ultrasonic waves.
- tissue conditions may be accessible to contact ultrasound devices but would be impractical for contact ultrasound treatment.
- fresh or open wounds resulting from trauma, burns or surgical interventions are not suitable for direct contact ultrasound treatment because of the structural nature of the open wound and the painful condition associated with those wounds.
- conventional contact ultrasound may have a destructive effect on these types of open wounds due to the close proximity of an oscillating tip of an ultrasonic transducer relative to the already damaged tissue surface.
- the present invention provides an apparatus and a method for treating tissue, the apparatus including a generator and a transducer for generating ultrasonic energy and delivering the ultrasonic energy to the biological tissue, from a non-contact distance from the tissue, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect to the tissue, and of sonicating the medicament for causing the medicament to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue.
- the present invention further provides an apparatus and method for generating ultrasonic energy from a non-contact distance from the surface of the wound; and delivering the generated ultrasonic energy to the wound through a gaseous medium (“dry” approach), wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound.
- the present invention further relates to a method and device for spraying (“wet” approach) a wound surface to deliver drugs, kill bacteria, or cleanse a surface by non-contact application of an ultrasound transducer tip.
- the method applies ultrasonic waves to the wound without requiring direct or indirect (via a traditional coupling medium) contact between the ultrasonic wave transducer and the wound to be sprayed.
- the method of the invention comprises producing a directed spray of liquid or powder particles produced by contact of the liquid or powder with a free end surface of an ultrasonic transducer.
- the ultrasonic waves cause the spray to project outwardly from the distal end surface of the ultrasonic transducer, and the particle spray is directed onto the wound.
- the particles of the spray provide a medium for propagation of the ultrasonic waves emanating from the distal end surface.
- a directed particle spray created by low frequency ultrasound waves onto a wound delivers drug, kills bacteria on the wound, increases blood flow, and removes dirt and other contaminants from the wound's surface (mechanical cleansing).
- This method of drug delivery is particularly advantageous on tissues for which local topical application of a drug is desirable but contact with the tissue is to be avoided. Furthermore, the low frequency ultrasound waves used in the method energize the drug and cause penetration of the drug below the surface of the tissue, due to acoustic pressure, microcavitation, etc. Finally, the bacteria killing method is effective when applied to the surface whether the liquid or powder sprayed is a drug (an antiseptic or antibiotic), oil, saline, distilled water, etc.
- a drug an antiseptic or antibiotic
- FIG. 1 is a perspective view of an ultrasonic wound treatment system according to the present invention.
- FIG. 2 is a lateral schematic view of an ultrasonic sprayer according to the present invention.
- FIG. 3 is a partly cross-sectional view of an ultrasonic sprayer according to the present invention.
- FIG. 4 a is a detailed view of the sprayer illustrated in FIG. 3 for spraying liquid from a radiation surface.
- FIG. 4 b is a detailed view of the sprayer illustrated in FIG. 3 for spraying liquid from a side (radial) surface.
- FIG. 5 is a cross-sectional front view of a distal end of an ultrasonic transducer when liquid is delivered to the side or radiation surface of the transducer tip from 360° along its perimeter.
- FIG. 6 is a variation of FIG. 4 b illustrating the spraying effect by changing the angle between the ultrasound instrument and horizontal line from 0° to 90°.
- FIGS. 7 a - 7 g are each a front cross-sectional view of an ultrasound tip configuration.
- FIGS. 8 a - 8 i are each an enlarged side view of a different modification of a tip end shape of the ultrasonic sprayer according to the present invention.
- FIGS. 9 a , 9 b , and 9 c represent cross-sectional, distal, and lateral views, respectively, of the top of an ultrasonic sprayer having a slot, groove, or thread.
- FIG. 10 is a schematic representation of a method of delivery of ultrasonic energy delivered through a gaseous medium, accordance with another embodiment of the present invention.
- FIG. 11 is a plot of experimental results achieved upon delivering ultrasound energy substantially through a gaseous medium to a wound in accordance with the present invention.
- the device of the invention that produces a spray is characterized by means for first delivering the liquid to a lateral surface of an ultrasonic transducer tip adjacent to a free end surface such that the liquid is pulled to the free end surface by a vacuum (negative pressure) created by the ultrasound waves on the free end surface of the transducer tip.
- This effect can be achieved while the angle between the ultrasound instrument and the horizontal is modified up to 90°.
- This acoustical effect of delivering liquid from radial side of a tip to the free end was discovered by the inventor of this invention and is called the “Babaev effect”.
- This effect occurs when liquid is delivered to the radial surface of a transducer tip about its perimeter, up to 360° about its perimeter, e.g. from the top, side, bottom, etc.
- the device can have a so-called nozzle constructed from steel (non-disposable) or plastic (disposable) with a suitable valve design.
- the nozzle allows delivery of liquid to the lateral surface of the transducer tip or directly to the distal side (radiation surface) of the ultrasound transducer, for enabling the transducer to act as a sprayer or atomizer.
- One of the major advantages of the invention is the uniformity of the spray particles generated. Because liquid or powder is sprayed from a solid radiation surface, there is substantial uniformity of particle size, about 90% or greater, such as from about 90 to 96%. It is provided that the distal radiation surface is driven with constant frequency and amplitude to create the spray. It is also provided that the frequency and/or amplitude can be modulated during treatment and that the distal radiation surface is driven with a sinusoidal, rectangular, trapezoidal or triangular wave form.
- the step of producing the spray can further include operating the transducer to produce ultrasonic waves having a frequency of from about 18 kHz to 10,000 MHz.
- Frequencies below 18 kHz i.e., from about 1 to 18 kHz, can be used as well; however, this lower range is less desirable because this range of sound wave can be uncomfortable to the patient and operator (without ear protection or the like).
- Frequencies in the range of from about 30 to 100 kHz are used in some embodiments, and frequencies of about 40 kHz are used in one embodiment.
- the separation distance between the free end surface of the transducer and the surface or object to be sprayed should be a “non-contact” distance of at least 0.1 in. (2.5 mm). In one embodiment, the separation distance is from about 0.1 in. (2.5 mm) to 20 in. (51 cm), for example from about 0.1 in. (2.5 mm) to 5 in. (12.7 cm).
- the liquid or powder to be sprayed can be any appropriate carrier such as water (regular or distilled), saline solution, or oil to be applied to tissue (i.e., biological tissue or non-biological tissue), such as a vegetable, peanut, or canola oil, optionally with a soluble pharmaceutical, e.g., an antibiotic, antiseptic, conditioner, surfactant, emollient, or other active ingredient.
- tissue i.e., biological tissue or non-biological tissue
- a soluble pharmaceutical e.g., an antibiotic, antiseptic, conditioner, surfactant, emollient, or other active ingredient.
- the pharmaceutical or the like can be present in a concentration sufficiently low to be soluble but high enough to be effective for the intended purpose.
- the liquid to be sprayed could include a mixture of two or more immiscible liquids or a heterogeneous mixture of a solution and small particles. It is also within the scope of the invention that the spray could include particles, such as powder, and that the liquid in the reservoir could include powder.
- the spray produced according to the invention is directed to the object, surface, or tissue to be sprayed for the time and frequency required for accomplishing a particular purpose or treatment. It is believed that a minimum length of spray of at least one second will be required; however, the length or duration of the spray could be from about one second to as much as a minute or more, even 30 minutes. Numerous factors or circumstances, such as, for example, the area to be sprayed (e.g., the size of a wound), the volume rate of spray produced, the concentration of active ingredient, etc., will impact upon the duration and/or frequency of the spraying. Spraying could be required from one or more times daily to as little as two or three times a week or month.
- ultrasonic waves are applied to a wound without establishing contact, directly or indirectly, between the ultrasonic transducer and the wound.
- surfaces of the human body especially suited for treatment in accordance with the method of the present invention include infected and inflammatory situations in open wounds, including trauma or gun shut wounds, fire and chemical burns.
- embodiments of the method can be suited to directing a spray into orifices or other body crevices that are difficult to access.
- Wound treatment according to the method and apparatus of the present invention has several advantages. First, this method topically applies medicines such as liquid antibiotics to the wound surface without the need to contact infected, inflamed or painful tissue with an instrument. And second, a significant bactericidal effect occurs when a wound surface is sprayed using the method of the present invention.
- the method of the present invention decreases healing times for inflammatory and purulent infected wounds from about 1.5 to 3 times faster than traditional methods.
- This effect results from a bactericidal, blood flow increasing and mechanical cleansing effect of the atomized spray particles, which have ultrasound energy due to the ultrasonic waves.
- the spray mechanically scrubs the surface of tissue to remove dirt, dead tissue, and purulent buildup on the tissue surface.
- the mentioned healing effect also results of energized and highly activated antibiotics, and drug penetration into the tissue surface up to 0.5 mm in depth under influence of ultrasound waves.
- a combination of the low frequency ultrasonic waves and the sonicated medicines (highly activated by ultrasonic energy) destroys the surface bacteria, resulting in a higher disinfecting property of sonicated liquids as compared to ordinarily applied liquids.
- the spray of the present method also stimulates healthy cell growth to aid in granulation and epithelization of the healing tissue.
- the method of the present invention offers an approach that may re-establish use of some traditional antibiotics and establish a method for fighting bacteria without antibiotics when necessary.
- the effect of the method of the present invention in highly activating antibiotics may allow some traditional antibiotics to overcome bacteria which have become resistant to that antibiotic.
- the low frequency ultrasonic waves applied in accordance with the method of the present invention physically destroy bacteria.
- the combination of the highly activated antibiotics and of the low frequency ultrasonic waves in accordance with the method of the present invention produce a strong bactericidal effect not found in mere topical application or oral ingestion of antibiotics. This combined effect has been shown to significantly increase the healing of purulent infected wounds.
- the present method also provides a system of non-contact drug delivery without use of a compression sprayer system. This simplifies the design of a non-contact drug delivery sprayer and reduces the weight of the sprayer. More importantly, not using compression to propel the atomized particles preserves the ultrasound energy carried by the spray particles.
- the method of the present invention provides a method of compressionless non-contact drug delivery.
- an ultrasonic treatment system 2 includes an ultrasound generator 4 , connected to an ultrasound transducer 6 by a cable 8 .
- the generator 4 which is conventional, may have a front panel 10 with a power button 12 , a timer 14 , a control button 16 , a display 18 , and one or more jacks 20 , for example, for connecting a footswitch.
- a nozzle 22 having a liquid reservoir 24 with a valve 26 is attached to the distal portion of transducer 6 .
- Arrows 28 represent the direction of the spray produced.
- FIG. 2 is a simplified representation of an ultrasonic device and spray according to the invention.
- Transducer 6 has a distal transducer tip or horn 30 . Liquid from a liquid reservoir 32 flows through a valve 34 to a position adjacent the distal radiation surface 36 of a horn 30 . Transducer 6 is attached to an ultrasound source via cable 8 . A liquid mist is directed in the direction of arrows 38 to target tissue or surface 40 (wet approach).
- FIG. 3 is an enlarged, partly cross-sectional view of a section of FIG. 1 illustrating a spray created by the device according to the method of the present invention.
- This device is a modification and implementation of a device disclosed in U.S. Pat. No. 5,076,266, which is incorporated herein by reference.
- nozzle 22 surrounds ultrasound horn 30 .
- liquid reservoir 32 has a valve 34 positioned between reservoir 32 and the distal surface 36 of ultrasonic horn 30 .
- a conical spray pattern of liquid particles 42 is directed at a surface or tissue 44 of a target. This configuration is effective to spray liquid onto a surface and to deliver ultrasonic waves to that surface, such as, for example, the surface of a wound.
- Valve 34 allows liquid to flow to distal tip 36 as drops or as a continuous flow through gap 46 .
- Valve 34 may be located anywhere, including between reservoir 32 and horn 30 . Mechanical movement of the horn 30 in the direction x-x causes liquid to flow to the distal end of radiation surface 36 .
- FIG. 4( a ) is a view of the ultrasonic sprayer as used in accordance with the method of the present invention for spraying liquid 48 directed to distal end (radiation surface) 36 .
- FIG. 4( b ) is a view of the basic spraying method from side (radial) surface of the tip based on the Babaev effect.
- liquid or drug directed to the radiation surface 36 of ultrasound horn 30 becomes sonicated (ultrasonically energized), after being pulled forward by negative pressure (vacuum) created by ultrasound waves and sprays.
- liquid is delivered to the side of radiation surface 36 of transducer horn 30 about the perimeter of radiation surface 36 , up to 360° about its perimeter, e.g. from the top, side, bottom, etc.
- transducer horn 30 is elevated from the horizontal up to 90°. Due to the Babaev effect, liquid 48 still travels to radiation surface 36 .
- the ultrasound tip or horn may have a regular or irregular lateral cross-section, including circular, oval, elliptical, rectangular, trapezoidal, or a combination thereof.
- FIGS. 7( a ) to 7 ( g ) are each a view of a cross-section of an ultrasound tip or horn.
- the distal end shape of the ultrasound tip or horn longitudinal cross-section may vary, and may be rectangular, elliptical, oval, spherical, conical, curved, stepped, with chamfer, etc., as shown in FIGS.
- FIG. 8( e ) the shape of the distal end
- radiation beams are focused at a focal point.
- other forms or shapes of the distal end radiation beams are spread, thus partially reaching the target.
- Radial side surface of the distal end of the tip may have a slot (groove) or thread for liquid to be directed to the radiation surface ( FIGS. 9 a - 9 c ).
- FIGS. 9 a to 9 c are each a view of a radial side surface of the distal end of the tip which has a slot (groove) 19 or thread 20 for liquid to be directed to the radiation surface.
- the ultrasonic energy delivered has an intensity capable of providing a therapeutic effect to the wound 40 , exerting acoustic pressure and/or causing micro-cavitation.
- Acoustic pressure refers to a force that can be felt which is exerted through air between the transducer and the tissue being targeted.
- Microcavitation refers to the formation and pulsation of gas or vapor filled microscopic bubbles in fluids as a result of ultrasonically induced and regularly repeated pressure changes.
- Advantages to micro cavitation include the creation of acoustic streaming which is a steady circulation of fluid in blood vessels induced by ultrasound radiation force.
- the amplitude achieved by the ultrasonic energy is at least 3 microns, and at least 10 microns in one embodiment.
- the frequency used is in the range of 20 kHz-50 MHz, wherein a range is 20-200 kHz in some embodiments, another range is 20-40 kHz in embodiments and a value is 40 kHz in embodiment, wherein the lower limit of the frequency used is outside of the human hearing range in embodiments.
- a radiation surface 36 having a shape and size selected to achieve delivery of the ultrasonic energy to the wound where the delivered ultrasonic energy has an intensity capable of providing a therapeutic effect to the wound is advantageous in achieving delivery of the ultrasonic energy to the wound wherein the ultrasonic energy has an intensity capable of achieving a therapeutic effect to the wound.
- the radiation surface 36 has a relatively large diameter. Actual selection of the diameter is dependent upon the frequency and amplitude selected.
- the shape of the radiation surface 36 is selected from one of flat, concave, convex, or a combination thereof, and from the configurations shown in FIGS. 8 a - 8 i , or a combination thereof.
- ultrasonic energy is delivered to the wound without the use of the spray, i.e., the ultrasonic energy is delivered through a medium other than a spray, including a gaseous medium, such as pure air, e.g., ambient air, where the ultrasound transducer 6 is positioned at a non-contact distance from the wound for providing a therapeutic and beneficial effect.
- a gaseous medium such as pure air, e.g., ambient air
- the ultrasound waves even without the use of a spray, destroy surface bacteria and stimulate health cell growth. This method of wound treatment is particularly advantageous on wounds for which contact with the wound should be avoided.
- an ultrasonic treatment system 2 ′ including an ultrasound generator 4 ′ connected to an ultrasound transducer 6 ′ by a cable 8 ′ for generating ultrasound energy.
- Transducer 6 ′ has a radiation surface 36 ′ from which the ultrasound energy is emitted and directed to wound 40 ′.
- the generator 4 ′ which is conventional, may have a front panel 10 ′ with a power button 12 ′, a timer 14 ′, a control button 16 ′, a display 18 ′, and one or more jacks 20 ′, for example, for connecting a footswitch.
- Arrows 100 represents the direction of ultrasound energy generated and directed toward wound 40 ′.
- a liquid or powder is not contacted with the ultrasonic transducer for generating a spray and directing it to the wound 40 ′.
- the ultrasonic energy is delivered through a medium other than a spray, including a gaseous medium, such as pure air (“dry” approach).
- a horn of the transducer 6 ′ may be configured in accordance with the embodiments shown in FIGS. 7 a - g , 8 a - i and/or 9 a - c.
- the frequency of the ultrasonic energy generated is selected to be a low frequency.
- a particular or predetermined amplitude for the generated ultrasonic energy is achieved, which is capable of being delivered to the wound with an intensity capable of providing a therapeutic effect to the wound 40 ′, exerting acoustic pressure and/or causing micro-cavitation.
- the amplitude achieved by the ultrasonic energy is at least 3 microns, such as at least 10 microns.
- the frequency used is in the range of 20 kHz-50 MHz, wherein a range is 20-200 kHz in embodiments, 20-40 kHz in other embodiments, and a is 40 kHz in one embodiment, wherein the lower limit of the frequency used is outside of the human hearing range in embodiments.
- a radiation surface 36 ′ having a shape and size selected to achieve delivery of the ultrasonic energy to the wound where the delivered ultrasonic energy has an intensity capable of providing a therapeutic effect to the wound is advantageous in achieving delivery of the ultrasonic energy to the wound wherein the ultrasonic energy has an intensity capable of achieving a therapeutic effect to the wound.
- the perimeter of the radiation surface 36 ′ is round, rectangular, elliptical, oval, spherical, conical, curved, stepped, with chamfer, etc., or a combination thereof, as shown in FIGS.
- the radiation surface 36 ′ is selected from one of flat, concave, convex, and a combination thereof.
- ultrasonic energy was delivered to the wound having an intensity capable of providing a therapeutic effect to the wound; the intensity being within the range of from 0.1 W/cm 2 to 10 W/cm 2 .
- the ultrasound energy is delivered to the wound or tissue being treated through a medium other than a spray, including a gaseous medium, such as pure air, e.g., ambient air, including without the use of the spray.
- a gaseous medium such as pure air, e.g., ambient air
- the ultrasound energy is delivered to the tissue through a substantial expanse of a substantially purely gaseous medium, such as ambient air.
- the transducer can be positioned at a non-contact distance from the tissue, where the space between the transducer and the tissue through which the ultrasound energy is delivered is an expanse of a substantially purely gaseous medium spanning a distance of at least about 0.1 in. (2.5 mm) from the transducer to the tissue.
- the distance spanned is from about 0.1 in. (2.5 mm) to 20 in. (51 cm), and is from about 0.1 in. (2.5 mm) to 5 in. (12.7 cm) in some embodiments.
- the embodiment shown in FIGS. 2-6 may further be used for delivering ultrasound energy to the skin without the use of a spray by not providing a liquid within the reservoir 32 so that liquid does not flow to the radiation surface 36 , or by selectively controlling delivery of liquid from the reservoir to the radiation surface 36 in accordance with one or more requests from an operator and/or a control module.
- the operator may make a request via a selection device which may be mechanical and/or electrical, e.g., a button, trigger, lever and/or user interface.
- the request may be processed mechanically and/or electrically (by analog and/or digital processing) for mechanically controlling flow of the liquid, such as by controlling the valve 34 to remain open or closed or sequentially open and close, in any order.
- non-contact ultrasound treatment without a spray may be provided to tissue using either the embodiment shown in FIGS. 1-6 or the embodiment shown in FIG. 10 .
- the reservoir may be provided in a device separate from the transducer and the spray may be generated and delivered from another device separate from the transducer, where the separate device may be detached from or attached to the transducer.
- the spray from the separate device may be a spray generated and delivered by another transducer or by a device that does not use ultrasound energy. Similar to the embodiment described with respect to FIGS. 1-6 in which the spray is delivered simultaneously with delivery of the ultrasound energy, the spray delivered from a separate device may be delivered simultaneously with delivery of the ultrasound energy. Alternatively, the spray may be delivered prior to delivery of the ultrasound energy, as described further below.
- a treatment may include a series of continual and/or intermittent treatments, wherein individual treatments of the series of treatments are selected from the group consisting of: delivery of ultrasound energy with the use of a spray, i.e., the wet approach as described with respect to FIGS. 1-6 ; and delivery of ultrasound energy through a medium other than a spray (i.e., a gaseous medium), i.e., the dry approach as described with respect to FIG. 10 , with the two or more steps performed in any order.
- a medium other than a spray i.e., a gaseous medium
- non-contact ultrasound treatment with or without a spray may be provided to tissue using either using the embodiment described with respect to FIGS. 1-6 or the embodiment shown in FIG. 10 .
- the liquid or powder to be sprayed may be an analgesic, such as for use as a local anesthetic, such as prior to a dental procedure, suturing, or other invasive or noninvasive procedure or for relief of pain.
- the analgesic is sonicated, providing a more immediate effect, a more potent effect, further penetration into the skin, improved precision of dosage, and a more targeted affect for minimizing effects to untargeted tissue.
- the low frequency ultrasonic waves applied in accordance with a method of the present invention such as through the medium of a spray formed from a saline solution, provide an analgesic effect.
- the combination of the sonicated analgesic and of the low frequency ultrasonic waves in accordance with a method of the present invention produce a strong local anesthetic effect not found in mere topical application of analgesics.
- Another embodiment of a method of the invention includes the step of providing a substance, such as a medicament and herein referred to as medicament, for application of the medicament to tissue, and delivering ultrasound energy to the medicament as it is applied or once it is applied and to the tissue using the embodiment shown in FIGS. 1-6 or the embodiment shown in FIG. 10 , and the amplitude, frequency, non-contact distance and other parameters for the ultrasound energy, generator and transducer described above.
- a substance such as a medicament and herein referred to as medicament
- the ultrasound energy is delivered by a non-contact delivery (i.e., without contacting the transducer 6 or 6 ′ to the tissue) to the tissue, as described above, and may be delivered through a spray or without a spray, e.g., by delivering the ultrasound energy through a medium other than a spray, such as ambient air, gas, etc.
- the medicament is, for example, an antibiotic, an ointment, cream, gel, liquid, salve, oil, saline solution, distilled, non-distilled and/or boiled water, powder, spray, antibacterial agent, antiseptic agent, insulin, analgesic agent, conditioner, surfactant, emollient, or other active ingredient, or a combination thereof.
- the medicament may be applied directly to the tissue before the ultrasound energy is delivered to the tissue, and/or during the delivery of the ultrasound energy to the tissue.
- the medicament may be provided within at least one container from which the medicament is applied to the tissue, where the container is in contact with the tissue, proximate the tissue and/or spaced from the tissue and oriented for directing the medicament at the tissue.
- the container may have a permeable wall(s) through which the medicament may pass directly to or towards the tissue, manually, automatically and/or mechanically, and/or through which the ultrasound energy may penetrate.
- the container may be integrated with or separated from the housing of the transducer 6 or 6 ′.
- the medicament may be applied below the tissue in addition to or instead of to the surface of the tissue.
- the various medicaments and methods for applying the medicament to the tissue may be used sequentially in any combination or sequence in conjunction with application of the ultrasound energy (delivered with and/or without the spray, or sequentially with and without the spray in any sequence).
- the sequence may include wait periods during which the ultrasound energy is not applied.
- a treatment may include a series of treatments, wherein individual treatments of the series of treatments are selected from the group consisting of: the treatment including the steps of delivering ultrasonic energy from a non-contact distance to the tissue simultaneous with delivery of a spray to the tissue, wherein the ultrasonic energy has an intensity capable of penetrating the tissue to a beneficial depth to provide a therapeutic effect to the tissue and sonicating the spray for causing the medicament to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue; the treatment including the steps of delivering ultrasonic energy from a non-contact distance to the tissue through a substantial expanse of a substantially purely gaseous medium to the tissue, wherein the ultrasonic energy has an intensity capable of penetrating the tissue to a beneficial depth to provide a therapeutic effect to the tissue; and the treatment including the steps of the method of the invention, wherein a different medicament is applied.
- the sonicated medicament and the combination of the sonicated medicament and the low frequency ultrasound waves each provide at least advantages similar to the advantages provided by the sonicated spray and the combination of the sonicated spray and low frequency ultrasound waves. Such advantages include increasing potency of the medicament, obtaining more immediate results, decreasing the volume of the medicament used relative to a volume used for a comparable treatment using traditional methods for achieving the same effect, increased precision of dosage of the medicament, re-establishment of traditional antibiotics to which bacteria have become resistant and deeper penetration into the tissue.
- the substance may be applied to surfaces other than tissue for non-medical applications, such as cleansing, sterilizing and coating surfaces of objects and food.
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Abstract
An apparatus and method are provided for applying a medicament to tissue, and delivering ultrasonic energy from a non-contact distance from the tissue to the medicament and to the tissue, wherein the ultrasonic energy has intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect to the tissue, and of sonicating the medicament for causing the medicament to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue.
Description
- This application is a continuation of application Ser. No. 10/815,384 filed Apr. 1, 2004, which in turn is a continuation-in-part of application Ser. No. 10/409,272 filed Apr. 7, 2003, which in turn is a continuation-in-part of application Ser. No. 09/669,312, filed Sep. 25, 2000, now U.S. Pat. No. 6,569,099, issued May 27, 2003, each of which is hereby fully incorporated herein by reference.
- The present invention relates to methods of using ultrasonic waves in wound treatment. More particularly, the present invention relates to a method of applying a medicament to tissue and delivering ultrasound energy to the medicament and the tissue.
- Ultrasonic waves have been widely used in medical applications, including for both diagnostics and therapy as well as for many industrial applications. One diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or a human tissue. In this procedure, an ultrasonic transducer is placed in contact with the object or tissue via a coupling medium, and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue. Upon contact with various underlying structures, the waves are reflected back to a receiver adjacent the transducer. By comparison of the signals of the ultrasonic wave as sent with the reflected ultrasonic wave as received, an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors, and the like.
- Two therapeutic medical uses of ultrasound waves include aerosol mist production and contact physiotherapy. Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drugs to the lungs. Ultrasonic nebulizers operate by the passage of ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid at a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound energy. This technique can produce a very fine dense fog or mist. Aerosol mists produced by ultrasound are preferred over aerosol mists produced by other methods because a smaller particle size of aerosol can be obtained with the ultrasonic waves. One of the major shortcoming of inhalers and nebulizers is that the aerosol mist cannot be directed to a target area without an air stream, which decreases the efficiency of the ultrasound energy. Ultrasonic sprayers such as those sold by Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc. (see, for example, U.S. Pat. Nos. 4,153,201, 4,655,393, and 5,516,043) operate by passing liquid through a central orifice of an ultrasound instrument-tip. Major disadvantages of these sprayers include non-uniform particle size, heating of liquid flow, and less efficiency of ultrasound waves because of a demolished end (radiation) surface configuration of the tip.
- Contact physiotherapy applies ultrasonic waves directly to tissue in an attempt to produce a physical change in the tissue. In conventional ultrasound physiotherapy, an ultrasonic wave contacts the tissue via a coupling medium. Ultrasonic waves produced by the transducer travel through the coupling medium and into the tissue. The coupling medium is typically a bath of liquid, a jelly applied to the surface to be treated, or a water-filled balloon. Conventional techniques provide ultrasonic waves having an intensity of about 0.1 w/cm2 to 3 w/cm2 at a frequency of about 0.8 to 3 Megahertz. The treatment is applied to a skin surface for from about 1 to 30 minutes, two or three times a week. The coupling medium can provide a cooling effect which dissipates some of the energy produced by the ultrasonic transducer.
- More importantly, a coupling medium or direct contact between the tissue and ultrasonic transducer is necessary to transmit the ultrasonic waves to the skin surface because ambient air is a relatively poor medium for the propagation of ultrasonic waves.
- Several beneficial effects have been reported from contact ultrasound physiotherapy, such as, for example, the following: local improvement of the blood circulation, heating of the tissue, accelerated enzyme activity, muscle relaxation, pain reduction, and enhancement of natural healing processes. Despite these beneficial effects, current techniques of medical physiotherapy using ultrasonic waves are limited by the necessity of providing a direct contact interface between the ultrasonic transducer and the tissue to maintain an effective transmission of the ultrasonic waves from the transducer to the tissue.
- The necessity of direct contact with or without a coupling medium makes current methods undesirable. Some tissue conditions may be accessible to contact ultrasound devices but would be impractical for contact ultrasound treatment. For example, fresh or open wounds resulting from trauma, burns or surgical interventions are not suitable for direct contact ultrasound treatment because of the structural nature of the open wound and the painful condition associated with those wounds. Moreover, conventional contact ultrasound may have a destructive effect on these types of open wounds due to the close proximity of an oscillating tip of an ultrasonic transducer relative to the already damaged tissue surface.
- The present invention provides an apparatus and a method for treating tissue, the apparatus including a generator and a transducer for generating ultrasonic energy and delivering the ultrasonic energy to the biological tissue, from a non-contact distance from the tissue, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect to the tissue, and of sonicating the medicament for causing the medicament to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue.
- The present invention further provides an apparatus and method for generating ultrasonic energy from a non-contact distance from the surface of the wound; and delivering the generated ultrasonic energy to the wound through a gaseous medium (“dry” approach), wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound.
- The present invention further relates to a method and device for spraying (“wet” approach) a wound surface to deliver drugs, kill bacteria, or cleanse a surface by non-contact application of an ultrasound transducer tip. The method applies ultrasonic waves to the wound without requiring direct or indirect (via a traditional coupling medium) contact between the ultrasonic wave transducer and the wound to be sprayed.
- The method of the invention comprises producing a directed spray of liquid or powder particles produced by contact of the liquid or powder with a free end surface of an ultrasonic transducer. The ultrasonic waves cause the spray to project outwardly from the distal end surface of the ultrasonic transducer, and the particle spray is directed onto the wound. The particles of the spray provide a medium for propagation of the ultrasonic waves emanating from the distal end surface. According to the method of the present invention a directed particle spray created by low frequency ultrasound waves onto a wound, delivers drug, kills bacteria on the wound, increases blood flow, and removes dirt and other contaminants from the wound's surface (mechanical cleansing).
- This method of drug delivery is particularly advantageous on tissues for which local topical application of a drug is desirable but contact with the tissue is to be avoided. Furthermore, the low frequency ultrasound waves used in the method energize the drug and cause penetration of the drug below the surface of the tissue, due to acoustic pressure, microcavitation, etc. Finally, the bacteria killing method is effective when applied to the surface whether the liquid or powder sprayed is a drug (an antiseptic or antibiotic), oil, saline, distilled water, etc.
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FIG. 1 is a perspective view of an ultrasonic wound treatment system according to the present invention. -
FIG. 2 is a lateral schematic view of an ultrasonic sprayer according to the present invention. -
FIG. 3 is a partly cross-sectional view of an ultrasonic sprayer according to the present invention. -
FIG. 4 a is a detailed view of the sprayer illustrated inFIG. 3 for spraying liquid from a radiation surface. -
FIG. 4 b is a detailed view of the sprayer illustrated inFIG. 3 for spraying liquid from a side (radial) surface. -
FIG. 5 is a cross-sectional front view of a distal end of an ultrasonic transducer when liquid is delivered to the side or radiation surface of the transducer tip from 360° along its perimeter. -
FIG. 6 is a variation ofFIG. 4 b illustrating the spraying effect by changing the angle between the ultrasound instrument and horizontal line from 0° to 90°. -
FIGS. 7 a-7 g are each a front cross-sectional view of an ultrasound tip configuration. -
FIGS. 8 a-8 i are each an enlarged side view of a different modification of a tip end shape of the ultrasonic sprayer according to the present invention. -
FIGS. 9 a, 9 b, and 9 c represent cross-sectional, distal, and lateral views, respectively, of the top of an ultrasonic sprayer having a slot, groove, or thread. -
FIG. 10 is a schematic representation of a method of delivery of ultrasonic energy delivered through a gaseous medium, accordance with another embodiment of the present invention. -
FIG. 11 is a plot of experimental results achieved upon delivering ultrasound energy substantially through a gaseous medium to a wound in accordance with the present invention. - The device of the invention that produces a spray is characterized by means for first delivering the liquid to a lateral surface of an ultrasonic transducer tip adjacent to a free end surface such that the liquid is pulled to the free end surface by a vacuum (negative pressure) created by the ultrasound waves on the free end surface of the transducer tip. This effect can be achieved while the angle between the ultrasound instrument and the horizontal is modified up to 90°. (This acoustical effect of delivering liquid from radial side of a tip to the free end was discovered by the inventor of this invention and is called the “Babaev effect”.) This effect occurs when liquid is delivered to the radial surface of a transducer tip about its perimeter, up to 360° about its perimeter, e.g. from the top, side, bottom, etc.
- For the above purpose the device can have a so-called nozzle constructed from steel (non-disposable) or plastic (disposable) with a suitable valve design. The nozzle allows delivery of liquid to the lateral surface of the transducer tip or directly to the distal side (radiation surface) of the ultrasound transducer, for enabling the transducer to act as a sprayer or atomizer.
- One of the major advantages of the invention is the uniformity of the spray particles generated. Because liquid or powder is sprayed from a solid radiation surface, there is substantial uniformity of particle size, about 90% or greater, such as from about 90 to 96%. It is provided that the distal radiation surface is driven with constant frequency and amplitude to create the spray. It is also provided that the frequency and/or amplitude can be modulated during treatment and that the distal radiation surface is driven with a sinusoidal, rectangular, trapezoidal or triangular wave form.
- The step of producing the spray can further include operating the transducer to produce ultrasonic waves having a frequency of from about 18 kHz to 10,000 MHz. Frequencies below 18 kHz, i.e., from about 1 to 18 kHz, can be used as well; however, this lower range is less desirable because this range of sound wave can be uncomfortable to the patient and operator (without ear protection or the like). Frequencies in the range of from about 30 to 100 kHz are used in some embodiments, and frequencies of about 40 kHz are used in one embodiment.
- The separation distance between the free end surface of the transducer and the surface or object to be sprayed should be a “non-contact” distance of at least 0.1 in. (2.5 mm). In one embodiment, the separation distance is from about 0.1 in. (2.5 mm) to 20 in. (51 cm), for example from about 0.1 in. (2.5 mm) to 5 in. (12.7 cm). The liquid or powder to be sprayed can be any appropriate carrier such as water (regular or distilled), saline solution, or oil to be applied to tissue (i.e., biological tissue or non-biological tissue), such as a vegetable, peanut, or canola oil, optionally with a soluble pharmaceutical, e.g., an antibiotic, antiseptic, conditioner, surfactant, emollient, or other active ingredient. The pharmaceutical or the like can be present in a concentration sufficiently low to be soluble but high enough to be effective for the intended purpose.
- It is within the scope of the invention that the liquid to be sprayed could include a mixture of two or more immiscible liquids or a heterogeneous mixture of a solution and small particles. It is also within the scope of the invention that the spray could include particles, such as powder, and that the liquid in the reservoir could include powder.
- The spray produced according to the invention is directed to the object, surface, or tissue to be sprayed for the time and frequency required for accomplishing a particular purpose or treatment. It is believed that a minimum length of spray of at least one second will be required; however, the length or duration of the spray could be from about one second to as much as a minute or more, even 30 minutes. Numerous factors or circumstances, such as, for example, the area to be sprayed (e.g., the size of a wound), the volume rate of spray produced, the concentration of active ingredient, etc., will impact upon the duration and/or frequency of the spraying. Spraying could be required from one or more times daily to as little as two or three times a week or month.
- According to embodiments, ultrasonic waves are applied to a wound without establishing contact, directly or indirectly, between the ultrasonic transducer and the wound. For example, surfaces of the human body especially suited for treatment in accordance with the method of the present invention include infected and inflammatory situations in open wounds, including trauma or gun shut wounds, fire and chemical burns.
- In addition, embodiments of the method can be suited to directing a spray into orifices or other body crevices that are difficult to access.
- Wound treatment according to the method and apparatus of the present invention has several advantages. First, this method topically applies medicines such as liquid antibiotics to the wound surface without the need to contact infected, inflamed or painful tissue with an instrument. And second, a significant bactericidal effect occurs when a wound surface is sprayed using the method of the present invention.
- Moreover, aside from the bactericidal effect and advantages of non-contact treatment, it has been found that using the method of the present invention gave a significant reduction in volume used of liquid medicine used as compared with traditional methods for wound treatment. Similarly, this allows for precise dosage of the sprayed liquid to permit a user, such as a physician, to administer the desired volume of liquid at a desired rate and duration.
- It has been found that the method of the present invention decreases healing times for inflammatory and purulent infected wounds from about 1.5 to 3 times faster than traditional methods. This effect results from a bactericidal, blood flow increasing and mechanical cleansing effect of the atomized spray particles, which have ultrasound energy due to the ultrasonic waves. The spray mechanically scrubs the surface of tissue to remove dirt, dead tissue, and purulent buildup on the tissue surface. The mentioned healing effect also results of energized and highly activated antibiotics, and drug penetration into the tissue surface up to 0.5 mm in depth under influence of ultrasound waves.
- Additionally, a combination of the low frequency ultrasonic waves and the sonicated medicines (highly activated by ultrasonic energy) destroys the surface bacteria, resulting in a higher disinfecting property of sonicated liquids as compared to ordinarily applied liquids.
- The spray of the present method also stimulates healthy cell growth to aid in granulation and epithelization of the healing tissue.
- Other applications of the invention can be directed to non-medical uses such as cleansing, sterilizing and coating surfaces of objects and food.
- The method of the present invention offers an approach that may re-establish use of some traditional antibiotics and establish a method for fighting bacteria without antibiotics when necessary. The effect of the method of the present invention in highly activating antibiotics may allow some traditional antibiotics to overcome bacteria which have become resistant to that antibiotic. Moreover, independent of the sonication effect of the antibiotics, the low frequency ultrasonic waves applied in accordance with the method of the present invention physically destroy bacteria. The combination of the highly activated antibiotics and of the low frequency ultrasonic waves in accordance with the method of the present invention produce a strong bactericidal effect not found in mere topical application or oral ingestion of antibiotics. This combined effect has been shown to significantly increase the healing of purulent infected wounds.
- The present method also provides a system of non-contact drug delivery without use of a compression sprayer system. This simplifies the design of a non-contact drug delivery sprayer and reduces the weight of the sprayer. More importantly, not using compression to propel the atomized particles preserves the ultrasound energy carried by the spray particles.
- Delivery of ultrasound energy in accordance with the present invention has been proven to destroy bacteria by action of the ultrasonic waves and by highly activated liquid medicines applied to the tissue.
- The method of the present invention provides a method of compressionless non-contact drug delivery.
- The invention is better appreciated by making reference to the drawings. In
FIG. 1 , anultrasonic treatment system 2 includes anultrasound generator 4, connected to anultrasound transducer 6 by acable 8. Thegenerator 4, which is conventional, may have afront panel 10 with apower button 12, atimer 14, acontrol button 16, adisplay 18, and one ormore jacks 20, for example, for connecting a footswitch. Anozzle 22 having aliquid reservoir 24 with avalve 26 is attached to the distal portion oftransducer 6.Arrows 28 represent the direction of the spray produced. -
FIG. 2 is a simplified representation of an ultrasonic device and spray according to the invention.Transducer 6 has a distal transducer tip orhorn 30. Liquid from aliquid reservoir 32 flows through avalve 34 to a position adjacent thedistal radiation surface 36 of ahorn 30.Transducer 6 is attached to an ultrasound source viacable 8. A liquid mist is directed in the direction ofarrows 38 to target tissue or surface 40 (wet approach). -
FIG. 3 is an enlarged, partly cross-sectional view of a section ofFIG. 1 illustrating a spray created by the device according to the method of the present invention. This device is a modification and implementation of a device disclosed in U.S. Pat. No. 5,076,266, which is incorporated herein by reference. As can be seen in more detail inFIG. 3 ,nozzle 22 surroundsultrasound horn 30. Also,liquid reservoir 32 has avalve 34 positioned betweenreservoir 32 and thedistal surface 36 ofultrasonic horn 30. A conical spray pattern ofliquid particles 42 is directed at a surface ortissue 44 of a target. This configuration is effective to spray liquid onto a surface and to deliver ultrasonic waves to that surface, such as, for example, the surface of a wound. -
Valve 34 allows liquid to flow todistal tip 36 as drops or as a continuous flow throughgap 46.Valve 34 may be located anywhere, including betweenreservoir 32 andhorn 30. Mechanical movement of thehorn 30 in the direction x-x causes liquid to flow to the distal end ofradiation surface 36. -
FIG. 4( a) is a view of the ultrasonic sprayer as used in accordance with the method of the present invention for sprayingliquid 48 directed to distal end (radiation surface) 36. -
FIG. 4( b) is a view of the basic spraying method from side (radial) surface of the tip based on the Babaev effect. In this example, liquid or drug directed to theradiation surface 36 ofultrasound horn 30 becomes sonicated (ultrasonically energized), after being pulled forward by negative pressure (vacuum) created by ultrasound waves and sprays. - As shown in
FIG. 5 , liquid is delivered to the side ofradiation surface 36 oftransducer horn 30 about the perimeter ofradiation surface 36, up to 360° about its perimeter, e.g. from the top, side, bottom, etc. - In the embodiment of the invention shown in
FIG. 6 , a partial section oftransducer horn 30 is elevated from the horizontal up to 90°. Due to the Babaev effect, liquid 48 still travels toradiation surface 36. - The ultrasound tip or horn may have a regular or irregular lateral cross-section, including circular, oval, elliptical, rectangular, trapezoidal, or a combination thereof. For example,
FIGS. 7( a) to 7(g) are each a view of a cross-section of an ultrasound tip or horn. Also, the distal end shape of the ultrasound tip or horn longitudinal cross-section may vary, and may be rectangular, elliptical, oval, spherical, conical, curved, stepped, with chamfer, etc., as shown inFIGS. 8( a) to 8(n), which are each an enlarged view in section of a different, exemplary modification of a tip of the sprayer as used in accordance with the method of the present invention. The shape can be rectangular in one embodiment, because radiation beams from ultrasound tip surface are substantially fully directed to the target (wound). With the spherical, elliptic and oval (FIG. 8( e)) form or shape of the distal end, radiation beams are focused at a focal point. However, with other forms or shapes of the distal end, radiation beams are spread, thus partially reaching the target. - Radial side surface of the distal end of the tip may have a slot (groove) or thread for liquid to be directed to the radiation surface (
FIGS. 9 a-9 c). -
FIGS. 9 a to 9 c are each a view of a radial side surface of the distal end of the tip which has a slot (groove) 19 orthread 20 for liquid to be directed to the radiation surface. - The ultrasonic energy delivered has an intensity capable of providing a therapeutic effect to the
wound 40, exerting acoustic pressure and/or causing micro-cavitation. Acoustic pressure refers to a force that can be felt which is exerted through air between the transducer and the tissue being targeted. Microcavitation refers to the formation and pulsation of gas or vapor filled microscopic bubbles in fluids as a result of ultrasonically induced and regularly repeated pressure changes. Advantages to micro cavitation include the creation of acoustic streaming which is a steady circulation of fluid in blood vessels induced by ultrasound radiation force. - In one embodiment, the amplitude achieved by the ultrasonic energy is at least 3 microns, and at least 10 microns in one embodiment. In embodiments, the frequency used is in the range of 20 kHz-50 MHz, wherein a range is 20-200 kHz in some embodiments, another range is 20-40 kHz in embodiments and a value is 40 kHz in embodiment, wherein the lower limit of the frequency used is outside of the human hearing range in embodiments.
- Furthermore, it is advantageous in embodiments to use a
radiation surface 36 having a shape and size selected to achieve delivery of the ultrasonic energy to the wound where the delivered ultrasonic energy has an intensity capable of providing a therapeutic effect to the wound. Selection of the shape and size of theradiation surface 36 in combination with selection of the frequency and amplitude of the ultrasonic energy used is advantageous in achieving delivery of the ultrasonic energy to the wound wherein the ultrasonic energy has an intensity capable of achieving a therapeutic effect to the wound. In embodiments, theradiation surface 36 has a relatively large diameter. Actual selection of the diameter is dependent upon the frequency and amplitude selected. Furthermore, the shape of theradiation surface 36 is selected from one of flat, concave, convex, or a combination thereof, and from the configurations shown inFIGS. 8 a-8 i, or a combination thereof. - In another embodiment, ultrasonic energy is delivered to the wound without the use of the spray, i.e., the ultrasonic energy is delivered through a medium other than a spray, including a gaseous medium, such as pure air, e.g., ambient air, where the
ultrasound transducer 6 is positioned at a non-contact distance from the wound for providing a therapeutic and beneficial effect. The ultrasound waves, even without the use of a spray, destroy surface bacteria and stimulate health cell growth. This method of wound treatment is particularly advantageous on wounds for which contact with the wound should be avoided. - With reference to
FIG. 10 , anultrasonic treatment system 2′ is shown including anultrasound generator 4′ connected to anultrasound transducer 6′ by acable 8′ for generating ultrasound energy.Transducer 6′ has aradiation surface 36′ from which the ultrasound energy is emitted and directed to wound 40′. Thegenerator 4′, which is conventional, may have afront panel 10′ with apower button 12′, atimer 14′, acontrol button 16′, adisplay 18′, and one ormore jacks 20′, for example, for connecting a footswitch.Arrows 100 represents the direction of ultrasound energy generated and directed towardwound 40′. Unlike the above embodiments, a liquid or powder is not contacted with the ultrasonic transducer for generating a spray and directing it to thewound 40′. The ultrasonic energy is delivered through a medium other than a spray, including a gaseous medium, such as pure air (“dry” approach). A horn of thetransducer 6′ may be configured in accordance with the embodiments shown inFIGS. 7 a-g, 8 a-i and/or 9 a-c. - In one embodiment, wherein the ultrasonic energy is delivered to the
wound 40′ through a gaseous medium, such as pure air, for achieving a therapeutic effect at thewound 40′, the frequency of the ultrasonic energy generated is selected to be a low frequency. By using a low frequency, a particular or predetermined amplitude for the generated ultrasonic energy is achieved, which is capable of being delivered to the wound with an intensity capable of providing a therapeutic effect to thewound 40′, exerting acoustic pressure and/or causing micro-cavitation. In embodiments, the amplitude achieved by the ultrasonic energy is at least 3 microns, such as at least 10 microns. In embodiments, the frequency used is in the range of 20 kHz-50 MHz, wherein a range is 20-200 kHz in embodiments, 20-40 kHz in other embodiments, and a is 40 kHz in one embodiment, wherein the lower limit of the frequency used is outside of the human hearing range in embodiments. - Furthermore, it is advantageous to use a
radiation surface 36′ having a shape and size selected to achieve delivery of the ultrasonic energy to the wound where the delivered ultrasonic energy has an intensity capable of providing a therapeutic effect to the wound. Selection of the shape and size of theradiation surface 36′ in combination with selection of the frequency and amplitude of the ultrasonic energy used is advantageous in achieving delivery of the ultrasonic energy to the wound wherein the ultrasonic energy has an intensity capable of achieving a therapeutic effect to the wound. In embodiments, the perimeter of theradiation surface 36′ is round, rectangular, elliptical, oval, spherical, conical, curved, stepped, with chamfer, etc., or a combination thereof, as shown inFIGS. 8( a) to 8(n), and has a relatively large diameter. Actual selection of the diameter is dependent upon the frequency and amplitude selected. Furthermore, the shape of theradiation surface 36′ is selected from one of flat, concave, convex, and a combination thereof. - With respect to
FIG. 11 , results are shown of experimentation at Celleration Acoustic Laboratory, Eden Prairie, Minn. Ultrasonic energy having an intensity capable of providing a therapeutic effect was delivered through air (no spraying of liquid or powder) to a wound using an ultrasound transducer positioned at a non-contact distance from the surface of the wound, as shown byFIG. 10 . The ultrasonic energy was generated at a frequency of 40 kHz and an amplitude of 61 microns. The transducer radiation surface was flat, rounded and had a diameter of 1 cm. Hydrophone model number PVDF-Z44-1000 and hydrophone amplifier model number Al7db, both manufactured by ONDA Corporation, Sunnyvale, Calif., were employed, using an amplifier gain of 7.44. As shown, with the transducer positioned at a distance of between 2.5 mm and 38 mm from a wound, ultrasonic energy was delivered to the wound having an intensity capable of providing a therapeutic effect to the wound; the intensity being within the range of from 0.1 W/cm2 to 10 W/cm2. - With respect to
FIGS. 10-11 , the ultrasound energy is delivered to the wound or tissue being treated through a medium other than a spray, including a gaseous medium, such as pure air, e.g., ambient air, including without the use of the spray. Accordingly, the ultrasound energy is delivered to the tissue through a substantial expanse of a substantially purely gaseous medium, such as ambient air. In embodiments, the transducer can be positioned at a non-contact distance from the tissue, where the space between the transducer and the tissue through which the ultrasound energy is delivered is an expanse of a substantially purely gaseous medium spanning a distance of at least about 0.1 in. (2.5 mm) from the transducer to the tissue. In embodiments, the distance spanned is from about 0.1 in. (2.5 mm) to 20 in. (51 cm), and is from about 0.1 in. (2.5 mm) to 5 in. (12.7 cm) in some embodiments. - The embodiment shown in
FIGS. 2-6 may further be used for delivering ultrasound energy to the skin without the use of a spray by not providing a liquid within thereservoir 32 so that liquid does not flow to theradiation surface 36, or by selectively controlling delivery of liquid from the reservoir to theradiation surface 36 in accordance with one or more requests from an operator and/or a control module. The operator may make a request via a selection device which may be mechanical and/or electrical, e.g., a button, trigger, lever and/or user interface. The request may be processed mechanically and/or electrically (by analog and/or digital processing) for mechanically controlling flow of the liquid, such as by controlling thevalve 34 to remain open or closed or sequentially open and close, in any order. Accordingly, non-contact ultrasound treatment without a spray may be provided to tissue using either the embodiment shown inFIGS. 1-6 or the embodiment shown inFIG. 10 . - As described further below, the reservoir may be provided in a device separate from the transducer and the spray may be generated and delivered from another device separate from the transducer, where the separate device may be detached from or attached to the transducer. The spray from the separate device may be a spray generated and delivered by another transducer or by a device that does not use ultrasound energy. Similar to the embodiment described with respect to
FIGS. 1-6 in which the spray is delivered simultaneously with delivery of the ultrasound energy, the spray delivered from a separate device may be delivered simultaneously with delivery of the ultrasound energy. Alternatively, the spray may be delivered prior to delivery of the ultrasound energy, as described further below. Furthermore, a treatment may include a series of continual and/or intermittent treatments, wherein individual treatments of the series of treatments are selected from the group consisting of: delivery of ultrasound energy with the use of a spray, i.e., the wet approach as described with respect toFIGS. 1-6 ; and delivery of ultrasound energy through a medium other than a spray (i.e., a gaseous medium), i.e., the dry approach as described with respect toFIG. 10 , with the two or more steps performed in any order. Accordingly, non-contact ultrasound treatment with or without a spray may be provided to tissue using either using the embodiment described with respect toFIGS. 1-6 or the embodiment shown inFIG. 10 . - The liquid or powder to be sprayed (via the
reservoir 32,valve 34 and radiation surface 36 shown inFIGS. 1-6 or via a separate device) may be an analgesic, such as for use as a local anesthetic, such as prior to a dental procedure, suturing, or other invasive or noninvasive procedure or for relief of pain. The analgesic is sonicated, providing a more immediate effect, a more potent effect, further penetration into the skin, improved precision of dosage, and a more targeted affect for minimizing effects to untargeted tissue. Moreover, independent of the effect of the sonicated analgesic, the low frequency ultrasonic waves applied in accordance with a method of the present invention, such as through the medium of a spray formed from a saline solution, provide an analgesic effect. The combination of the sonicated analgesic and of the low frequency ultrasonic waves in accordance with a method of the present invention produce a strong local anesthetic effect not found in mere topical application of analgesics. - Another embodiment of a method of the invention includes the step of providing a substance, such as a medicament and herein referred to as medicament, for application of the medicament to tissue, and delivering ultrasound energy to the medicament as it is applied or once it is applied and to the tissue using the embodiment shown in
FIGS. 1-6 or the embodiment shown inFIG. 10 , and the amplitude, frequency, non-contact distance and other parameters for the ultrasound energy, generator and transducer described above. The ultrasound energy is delivered by a non-contact delivery (i.e., without contacting thetransducer - The medicament may be applied directly to the tissue before the ultrasound energy is delivered to the tissue, and/or during the delivery of the ultrasound energy to the tissue. The medicament may be provided within at least one container from which the medicament is applied to the tissue, where the container is in contact with the tissue, proximate the tissue and/or spaced from the tissue and oriented for directing the medicament at the tissue. The container may have a permeable wall(s) through which the medicament may pass directly to or towards the tissue, manually, automatically and/or mechanically, and/or through which the ultrasound energy may penetrate. The container may be integrated with or separated from the housing of the
transducer - The various medicaments and methods for applying the medicament to the tissue may be used sequentially in any combination or sequence in conjunction with application of the ultrasound energy (delivered with and/or without the spray, or sequentially with and without the spray in any sequence). The sequence may include wait periods during which the ultrasound energy is not applied. Specifically, a treatment may include a series of treatments, wherein individual treatments of the series of treatments are selected from the group consisting of: the treatment including the steps of delivering ultrasonic energy from a non-contact distance to the tissue simultaneous with delivery of a spray to the tissue, wherein the ultrasonic energy has an intensity capable of penetrating the tissue to a beneficial depth to provide a therapeutic effect to the tissue and sonicating the spray for causing the medicament to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue; the treatment including the steps of delivering ultrasonic energy from a non-contact distance to the tissue through a substantial expanse of a substantially purely gaseous medium to the tissue, wherein the ultrasonic energy has an intensity capable of penetrating the tissue to a beneficial depth to provide a therapeutic effect to the tissue; and the treatment including the steps of the method of the invention, wherein a different medicament is applied.
- Delivery of the ultrasound energy to the medicament and to the tissue energizes the medicament via sonication and causes penetration of the medicament into the tissue for providing an enhanced therapeutic effect to the tissue. Further, the delivery of the ultrasound energy causes exertion of acoustic pressure. The sonicated medicament and the combination of the sonicated medicament and the low frequency ultrasound waves each provide at least advantages similar to the advantages provided by the sonicated spray and the combination of the sonicated spray and low frequency ultrasound waves. Such advantages include increasing potency of the medicament, obtaining more immediate results, decreasing the volume of the medicament used relative to a volume used for a comparable treatment using traditional methods for achieving the same effect, increased precision of dosage of the medicament, re-establishment of traditional antibiotics to which bacteria have become resistant and deeper penetration into the tissue.
- The substance may be applied to surfaces other than tissue for non-medical applications, such as cleansing, sterilizing and coating surfaces of objects and food.
- The preceding specific embodiments are illustrative of the practice of the invention. It is to be understood, however, that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the spirit of the invention or the scope of the appended claims.
Claims (21)
1-47. (canceled)
48. An apparatus for treating a wound comprising:
means for generating ultrasonic energy; and
means for delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound in the absence of a coupling medium and without direct contact between the means for delivering the generated ultrasonic energy and the wound and other patient tissue, wherein the generated ultrasonic energy has an intensity in the range of about 0.25 watts/cm2-3 watts/cm2, and wherein the non-contact distance is at least 2.5 millimeters (mm) from the surface of the wound.
49. The apparatus according to claim 48 , wherein the means for generating includes means for generating the ultrasonic energy with a particular amplitude indicative of an intensity capable of achieving a therapeutic effect.
50. The apparatus according to claim 49 , wherein the means for generating further includes the means for generating the ultrasonic energy with a frequency capable of achieving the particular amplitude.
51. The apparatus according to claim 49 , wherein the particular amplitude is at least 10 microns.
52. The apparatus according to claim 49 , wherein the frequency is in the range of 20 kHz-5 MHz.
53. The apparatus according to claim 50 , wherein the frequency is in the range of 20-200 kHz.
54. The apparatus according to claim 50 , wherein the frequency is in the range of 20-40 kHz.
55. The apparatus according to claim 48 , wherein the means for delivering includes a radiation surface having a surface area dimensioned for achieving delivery of the ultrasonic energy to the wound with an intensity capable of achieving a therapeutic effect.
56. The apparatus according to claim 48 , wherein the means for delivering includes a radiation surface having a rounded perimeter for achieving delivery of the ultrasonic energy to the wound with an intensity capable of achieving a therapeutic effect.
57. The apparatus according to claim 48 , wherein the means for delivering includes a radiation surface; and a selection is made of at least one of a size of a surface area of the radiation surface, a shape of a peripheral boundary of the radiation surface, a frequency of the generated ultrasonic energy, and an amplitude of the generated ultrasonic energy for achieving delivery of ultrasonic energy to the wound with an intensity capable of achieving a therapeutic effect.
58. The apparatus according to claim 48 , wherein the means for delivering includes a radiation surface; and a selection is made of a combination of a size of a surface area of the radiation surface, a shape of a peripheral boundary of the radiation surface, a shape of the curvature of the radiation surface selected from one of flat, concave, convex and a combination thereof, a frequency of the generated ultrasonic energy, and an amplitude of the generated ultrasonic energy for achieving delivery of ultrasonic energy to the wound with an intensity capable of achieving a therapeutic effect.
59. The apparatus according to claim 55 , wherein a radiation surface of the means for delivering is positioned from 2.5 mm to 51 cm from the surface of the wound.
60. The apparatus according to claim 48 , wherein the means for delivering is driven by a constant or modulated frequency having a wave form selected from the group consisting of sinusoidal, rectangular, trapezoidal and triangular wave forms.
61. The apparatus according to claim 48 , wherein the method provides a therapeutic effect selected from the group consisting of increasing blood flow to the wound and stimulating cell growth.
62. An apparatus for treating a wound comprising:
an ultrasound generator;
an ultrasound transducer including a distal tip, which distal tip has a radiation surface from which ultrasonic energy is emitted for delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance of at least 2.5 millimeters (mm) from the surface of the wound in the absence of a coupling medium and without direct contact between the ultrasound transducer and the wound and other patient tissue; and
a nozzle, wherein the ultrasound transducer is interconnected to the ultrasound generator, and wherein the nozzle is attached to a portion of the ultrasound transducer to shield the distal tip.
63. The apparatus of claim 62 , wherein the ultrasonic energy has an intensity in the range of about 0.25 watts/cm2-3 watts/cm2.
64. An apparatus for treating a wound comprising:
means for generating ultrasonic energy; and
means for delivering the generated ultrasonic energy to the wound through a liquid coupling medium from a non-contact distance from the surface of the wound without direct contact between the means for delivering the generated ultrasonic energy and the wound and other patient tissue,
wherein the generated ultrasonic energy has an intensity in the range of about 0.25 watts/cm2-3 watts/cm2, and
wherein the non-contact distance is at least 2.5 millimeters (mm) from the surface of the wound.
65. The method of claim 64 , wherein the liquid coupling medium does not include a medicament.
66. The method according to claim 64 , wherein the liquid coupling medium is a medicament selected from at least one member of the group consisting of: an antibiotic, an ointment, cream, gel, liquid, salve, oil, powder, antibacterial agent, antiseptic agent, insulin, analgesic agent, conditioner, surfactant, emollient, or other active ingredients.
67. The method according to claim 66 , wherein means for delivering the generated ultrasonic energy to the wound delivers the medicament to the wound such that the medicament penetrates the wound to a beneficial depth to provide a therapeutic effect to the wound.
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US13/073,863 US20110230795A1 (en) | 2001-01-12 | 2011-03-28 | Ultrasonic method and device for wound treatment |
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US10/815,384 US7914470B2 (en) | 2001-01-12 | 2004-04-01 | Ultrasonic method and device for wound treatment |
US13/073,863 US20110230795A1 (en) | 2001-01-12 | 2011-03-28 | Ultrasonic method and device for wound treatment |
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US13/073,863 Abandoned US20110230795A1 (en) | 2001-01-12 | 2011-03-28 | Ultrasonic method and device for wound treatment |
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EP (1) | EP1617910A1 (en) |
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Also Published As
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WO2004091722A8 (en) | 2006-05-18 |
US20040186384A1 (en) | 2004-09-23 |
US7914470B2 (en) | 2011-03-29 |
CA2521117A1 (en) | 2004-10-28 |
JP2007521053A (en) | 2007-08-02 |
CA2521117C (en) | 2012-06-12 |
EP1617910A1 (en) | 2006-01-25 |
WO2004091722A1 (en) | 2004-10-28 |
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