US20050070990A1 - Medical devices and methods of making same - Google Patents

Medical devices and methods of making same Download PDF

Info

Publication number
US20050070990A1
US20050070990A1 US10/672,891 US67289103A US2005070990A1 US 20050070990 A1 US20050070990 A1 US 20050070990A1 US 67289103 A US67289103 A US 67289103A US 2005070990 A1 US2005070990 A1 US 2005070990A1
Authority
US
United States
Prior art keywords
weight
stent
alloy
mass
weight percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/672,891
Other languages
English (en)
Inventor
Jonathan Stinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US10/672,891 priority Critical patent/US20050070990A1/en
Assigned to SCIMED LIFE SYSTEMS, INC. reassignment SCIMED LIFE SYSTEMS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: STINSON, JONATHAN S.
Priority to CA002539491A priority patent/CA2539491A1/en
Priority to PCT/US2004/030645 priority patent/WO2005030095A2/en
Priority to JP2006528084A priority patent/JP4921170B2/ja
Priority to EP04784496A priority patent/EP1663071B1/en
Priority to AT04784496T priority patent/ATE531340T1/de
Priority to ES04784496T priority patent/ES2375961T3/es
Publication of US20050070990A1 publication Critical patent/US20050070990A1/en
Assigned to BOSTON SCIENTIFIC SCIMED, INC. reassignment BOSTON SCIENTIFIC SCIMED, INC. CHANGE OF NAME Assignors: SCIMED LIFE SYSTEMS, INC.
Priority to US12/643,629 priority patent/US8137614B2/en
Priority to US13/396,085 priority patent/US20120150276A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C14/00—Alloys based on titanium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00089—Zirconium or Zr-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00095—Niobium or Nb-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00101—Molybdenum or Mo-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00131—Tantalum or Ta-based alloys

Definitions

  • the invention relates to medical devices, such as, for example, stents and stent-grafts, and methods of making the devices.
  • the body includes various passageways such as arteries, other blood vessels, and other body lumens. These passageways sometimes become occluded or weakened. For example, the passageways can be occluded by a tumor, restricted by plaque, or weakened by an aneurysm. When this occurs, the passageway can be reopened or reinforced, or even replaced, with a medical endoprosthesis.
  • An endoprosthesis is typically a tubular member that is placed in a lumen in the body. Examples of endoprostheses include stents and covered stents, sometimes called “stent-grafts”.
  • An endoprosthesis can be delivered inside the body by a catheter that supports the endoprosthesis in a compacted or reduced-size form as the endoprosthesis is transported to a desired site. Upon reaching the site, the endoprosthesis is expanded, for example, so that it can contact the walls of the lumen.
  • MRI magnetic resonance imaging
  • MRI uses a magnetic field and radio waves to image the body.
  • the patient is exposed to a magnetic field, which interacts with certain atoms, e.g., hydrogen atoms, in the patient's body.
  • Incident radio waves are then directed at the patient.
  • the incident radio waves interact with atoms in the patient's body, and produce characteristic return radio waves.
  • the return radio waves are detected by a scanner and processed by a computer to generate an image of the body.
  • the invention features a system including a catheter for delivery into a body lumen.
  • the catheter includes an expandable member and a stent as described herein disposable over the expandable member.
  • the expandable member is expandable to a maximum diameter of about 1.55 mm to about 14 mm.
  • the invention features an implantable medical device including an alloy having Ti at about 20 weight percent or more and at least one of Zr, Ta, or Mo, a yield strength of about 45 ksi or more, a magnetic susceptibility of about +1 or less, and a mass absorption coefficient of about 1.9 cm 2 /g or more.
  • the medical device can be a filter, a guidewire, a catheter, a needle, a biopsy needle, a staple, or a cannula.
  • the invention features a method of forming a medical device.
  • the method includes providing a metal alloy of multiple components of elements or alloys, including a first component and a second component having a melting point difference of about 150° C. or more. Solid aliquots of the first component and the second component are contacted, heated and/or mechanically worked, then the worked components are melted. The alloy is incorporated into a medical device.
  • the invention features a medical device including a titanium alloy having at least one of zirconium, tantalum, molybdenum, or niobium.
  • the alloy exhibits radiopacity, MRI capability, mechanical properties, and/or biocompatibility properties, and combinations of the properties as described herein.
  • the invention features particular alloys and techniques for making the alloys.
  • Embodiments may include one or more of the following advantages.
  • a stent or other medical device is provided that includes desirable magnetic imaging radiopacity, biocompatibility and/or mechanical characteristics.
  • the stent is less susceptible to magnetic resonance image degradation (e.g., less than stainless steel) Implant movement or heating can be reduced.
  • the stent alloy has sufficient radiopacity that the stent is visible by fluoroscopy.
  • the mechanical characteristics of the alloy enable a stent of conventional design that can be delivered into the body in a reduced diameter configuration and then expanded at a treatment site, e.g., by a balloon catheter.
  • the titanium alloys generally can exhibit enhanced strength, stiffness and radiopacity, while maintaining low magnetic susceptibility.
  • FIGS. 1A and 1B are perspective views of a stent in a compressed and expanded condition, respectively.
  • FIGS. 2A-2C illustrate delivery of a balloon expandable stent.
  • FIG. 3 is a flow diagram of a stent manufacturing process.
  • FIGS. 4A-4F illustrate a process for making a medical device.
  • FIGS. 5-8 are photo micrographs.
  • a stent 10 includes a metal body 12 in the shape of a tube.
  • the metal body includes aperture regions 14 provided in a pattern to facilitate stent functions, such as radial expansion, and lateral flexibility. Between aperture regions are strut regions 16 .
  • the stent 10 is provided or maintained in a relatively small diameter condition corresponding to a diameter D c .
  • the stent 10 is expanded to a larger diameter, D exp , so that the stent is in contact with the lumen wall.
  • the stent may be expanded by a mechanical expander, such as an inflatable balloon, or it may be self-expanding.
  • the metal body of the stent may be formed by a generally continuous sheet or by filaments that are wrapped, braided, knitted or otherwise configured to generally define a stent.
  • the stent 300 is carried on a catheter 302 over a balloon 304 .
  • the balloon is expanded to expand the stent into contact with the lumen wall.
  • the stent may be used in the vascular system (e.g., in the coronary or peripheral arteries), or in other body lumens.
  • the stent body is formed of a metal alloy that has desirable magnetic resonance, radiopacity, biocompatibility, and/or mechanical characteristics.
  • the alloy is a titanium-containing alloy that includes one or more of Zr, Ta or Mo.
  • the alloy is formed from commercially pure (CP) titanium or Ti-6A1-4V ELI, which has been alloyed with one or more of Zr, Ta, or Mo by processes that include mechanical or diffusion alloying followed by melting, as will be described below.
  • the alloy is formulated to provide desired characteristics.
  • the alloy is formulated to reduce signal distortion, electrical current (e.g., eddy current) generation, heating, movement within the body or nerve simulation, by controlling the magnetic susceptibility and solubility of the alloy constituents.
  • the magnetic susceptibilities of Ti, Zr, Ta, and Mo and other materials are provided in Table I. TABLE I Magnetic Susceptibilities Material: Magnetic Susceptibility: Water at 37° C.
  • the magnetic susceptibility of the alloy is less than the magnetic susceptibility of austenitic stainless steel, e.g. about +1 or less or about 3.5 ⁇ 10 ⁇ 3 or less.
  • Solubility of the constituents can be determined by binary phase diagrams. Suitable solubility is indicated by a single phase (alpha or beta) or by a two phase solution (alpha and beta) at room temperature. Examples of suitable phase diagrams are available in the ASM Handbook, volume 3, ASM International, 1992, the entire contents of which is hereby incorporated by reference.
  • the alloy is formulated to a desired mass absorption coefficient.
  • the stent is readily visible by fluoroscopy, but does not appear so bright that detail in the fluoroscopic image is distorted.
  • the alloy or the device has a radiopacity of from about 1.10 to about 3.50 times (e.g., greater than or equal to about 1.1, 1.5, 2.0, 2.5, or 3.0 times; and/or less than or equal to about 3.5, 3.0, 2.5, 2.0, or 1.5 times) that of 316L grade stainless steel, as measured by ASTM F640 (Standard Test Methods for Radiopacity of Plastics for Medical Use).
  • Mass absorption coefficients and densities or Ti, Ta, Zr and Mo are compared to 316L stainless steel in Table II. TABLE II Mass Absorption Coefficients Alloy 316L SS Ti Ta Zr Mo Mass absorption 1.96 (Fe) 1.21 5.72 6.17 7.04 coefficient, cm 2 /g Density, g/cc 8.0 4.5 16.7 6.5 10.2
  • the mass absorption coefficient of the alloy is about 1.96 cm 2 /g (corresponding substantially to the mass absorption coefficient of Fe) to about 2.61 cm 2 /g (corresponding to about 0.5 the mass absorption coefficient of Ta).
  • Mass absorption coefficient can be calculated from the results of radiopacity tests, as described in The Physics of Radiology, H. E. Johns, J. R. Cunningham, Charles C. Thomas Publisher, 1983, Springfield, Ill., pp. 133-143. A calculation of alloy mass absorption coefficient is provided in the examples, infra.
  • the alloy is formulated based on solubility and phase structure.
  • the alloy exhibits certain mechanical properties within about ⁇ 20% (e.g., within about ⁇ 10%, about ⁇ 5%, or about ⁇ 1%) of the corresponding value for stainless steel.
  • Mechanical properties for select materials are provided in Table III. TABLE III Mean Tensile Test Data (Annealed Condition) 0.2% offset % strain UTS, % strain to E, Tubing Ys, ksi to peak load ksi fracture msi 316L SS 50 36 94 45 29 Tantalum 24 No data 35-70 40 27 CP Titanium 25-70 No data 35-80 15-25 15 Ti—6Al—4V 120 No data 130 15 17 ELI
  • Yield strength relates to the applied pressure needed to flow the alloy to expand the stent.
  • the percent strain to peak load indicates how far the material can strain before necking occurs.
  • the ultimate tensile strength (UTS) is the stress value that corresponds with strain to peak load.
  • the percent strain to fracture is a measure of how far the material can be stretched prior to break, and includes uniform deformation plus location deformation in the necked down region. This property relates to stent strut fracture from over-expansion of the stent. Suitable test methods for determining these parameters are described in ASTM E8 (Standard Test Methods for Tension Testing of Metallic Materials). In Table III, the 316L SS properties were measured from annealed stent tubing. The other material properties were taken from handbooks, such as American Society for Metals Handbook Desk Edition, H. E. Boyer, T. L. Gall, 1985.
  • phase diagrams The solubility of the constituents and phase structure of the alloy is indicated by phase diagrams. Suitable solubilities are indicated by alpha and/or beta microstructures without substantial amounts of more brittle phases such as alpha prime, alpha double prime or omega phases. Active rapid cooling after melting can be utilized to reduce precipitation of these phases.
  • the presence of brittle phases is less than about 10% (e.g., less than about 7%, 5%, or 3%) as measured by X-ray diffraction analysis.
  • the presence of two phases is preferably equal to or less than the amount in commercially available Ti-6A1-4V (available from Allegheny Technologies Allvac (Monroe, N.C.) or Metalmen Sales (Long Island City, N.Y.).
  • Alloying Ti with Ta and Mo increases modulus of elasticity. Alloying Ti with Ta, Mo, and/or Zr increases tensile strength. In embodiments, tensile properties are balanced by annealing the alloy. For example, annealing time and temperature can be selected to produce a maximum level of ductility while meeting minimum design requirements for yield strength and grain size. Alternatively or in addition, the stent design can be modified to accommodate less favorable mechanical properties.
  • the stent is designed to lower the strain on the struts during expansion, such as by increasing the number of deformation “hinge” points in the stent so that the total stent deformation is distributed in smaller amounts to the areas where deformation occurs.
  • Biocompatibility of the stent is provided by alloying biocompatible constituents or coating the sent with a biocompatible material. Biocompatibility can be tested by using industry standard ISO 10992 in-vitro and in vivo test methods, which can provide a qualitative pass or fail indication.
  • the stent has a biocompatibility similar to or equivalent to pure titanium or pure tantalum, as measured by ISO 10992 test methods.
  • the alloy constituents are provided in combinations and amounts recited in the Summary and Examples.
  • the alloy is Ti-Ta, Ti-Mo, Ti-Zr, Ti-Ta-Mo, Ti-Ta-Zr, Ti-Ta-Zr-Mo, Ti-Zr-Mo or Ti 6A1-4V-Ta, Ti 6A1-4V-Mo, Ti 6A1-4V-Zr, Ti 6A1-4V-Ta-Mo, Ti 6A1-4V-Ta-Zr, Ti 6A1-4V-Ta-Zr-Mo, or Ti 6A1-4V-Zr-Mo alloy.
  • Ti-13Nb-13Zr, Ti-8A1-1Mo-1V, Ti-6A1-2Nb-1 Ta-0.8Mo and Ti-7A1-4Mo one alloyed with Ta, Mo, and/or Zr.
  • the alloy is annealed.
  • the alloy is formed by alloying CP titanium or Ti-6A1-4V ELI with Ta, Zr and/or Mo.
  • the alloy includes 40 to 70 weight percent tantalum or 25 to 50 weight percent zirconium with CP titanium or Ti-6A1-4V ELI.
  • 5 to 20 weight percent molybdenum is added in place of some of the titanium for added tensile strength without sacrificing MRI compatibility.
  • Suitable alloys include the following: CP Titanium alloyed with: Ti—6Al—4V ELI alloyed with: 43 weight % Ta 43 weight % Ta 69 weight % Ta 69 weight % Ta 25 weight % Ta 25 weight % Ta 49 weight % Zr 49 weight % Zr 43 weight % Ta + 5% Mo 43 weight % Ta + 5% Mo 69 weight % Ta + 5% Mo 69 weight % Ta + 5% Mo 25 weight % Zr + 5% Mo 25 weight % Zr + 5% Mo 49 weight % Zr + 5% Mo 49 weight % Zr + 5% Mo 49 weight % Zr + 5% Mo 43 weight % Ta + 10% Mo 43 weight % Ta + 10% Mo 69 weight % Ta + 10% Mo 69 weight % Ta + 10% Mo 25 weight % Zr + 10% Mo 25 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight
  • a stent is constructed by forming an alloy, forming a tube from the alloy, and then forming the tube into a stent.
  • an alloying process is illustrated for forming an ingot or billet of a size and form suitable for stent construction.
  • a base rod 60 and one or more additive rods 62 are provided.
  • the base rod is Ti or a Ti-containing alloy and the additive rod(s) are Ti, Ta, Zr, and/or Mo.
  • the weight of the rods are in proportion to the desired alloy formulation.
  • the base rod is drilled to provide voids 64 .
  • additive rods 62 are inserted into the voids 64 of the base rod 60 .
  • this assembly is prealloyed by heating and/or mechanically working to cause diffusion alloying between constituents.
  • the alloy e.g., the alloyed billet is suitable for further processing.
  • the billet can be drawn into tubing or rolled into a sheet for stock stent tubing production.
  • an ingot or billet 2.5 inches in diameter by 4 inches long can typically yield at least 1000 feet of coronary stent tubing.
  • the alloying process is particularly advantageous for alloying constituents with large melting temperature differences.
  • Table IV the melting temperatures of Ti, Ta, Zr, and Mo are provided. TABLE IV Melting Temperatures Element Melting Temperature, ° C. Ti 1668 Ta 2996 Zr 1852 Mo 2610
  • the prelloying step heating is performed in an inert gas or vacuum, or the outer surfaces of the billet could be coated or canned with a protective metal, such as iron, that could later be chemically dissolved.
  • the billet can also be extruded, drawn, or rolled to further consolidate the assembly.
  • the heat treatment or working serves to hold additive material in place within the billet during melting.
  • constituents with high melting points can be essentially encapsulated within, e.g. titanium, minimizing the exposure to any residual air in the casting furnace.
  • the assembly can be heated near the melting temperature of the lowest melting temperature constituent and/or the melting temperature of the material of the base rod. For example, for a Ti base rod, the temperature is about 1600° C. or less.
  • additives to the base are made in incremental steps in each of multiple melting and ingot casting operations.
  • the Ti-6A1 -4V bar holes may be filled with 22 weight percent tantalum.
  • holes are drilled again and filled with another 22 weight percent tantalum and the melting is repeated.
  • Other sequences and magnitudes of Ta adds are made to reach the final alloy with 43 weight percent Ta.
  • This approach is Ta elemental segregation in the ingot if it is added in smaller amounts in multiple melting and ingot casting steps.
  • homogenization heat treatments between melts can reduce the amount of elemental diffusion needed.
  • the additive can be provided in the form of powder or chips rather than a solid wire or rod.
  • the alloying that occurs in the melting and ingot casting process can be further improved by performing a homogenization (elemental diffusion) heat treatment to the ingots between melting operations.
  • Mechanical alloying melting, casting, and heat treating operations can be performed at commercial sources such as Pittsburgh Materials Technology Inc. (Pittsburgh, Pa.), Applegate Group (Woodcliff Lake, N.J.) or Albany Research Center (Albany, Ore.).
  • the alloy tubing is formed into stent.
  • selected portions can be removed to define bands and struts.
  • the portions can be removed by laser cutting, as described, for example, in U.S. Pat. No. 5,780,807.
  • a liquid carrier such as a solvent, gas, or an oil
  • the carrier can prevent drops formed on one portion from re-depositing on another portion, and/or reduce formation of recast material on the tubular member.
  • Other methods of removing portions of tubular member include mechanical machining (e.g., micro-machining), electrical discharge machining (EDM), photoetching (e.g., acid photoetching), and/or chemical etching.
  • the stent can further be finished, e.g., electropolished to a smooth finish, according to conventional methods.
  • about 0.0001 inch of material can be removed from the interior and/or exterior surfaces by chemical milling and/or electropolishing.
  • the stent can be annealed to refine the mechanical and physical properties of the stent.
  • the stent can be used, e.g., delivered and expanded, using a catheter.
  • Suitable catheter systems are described in, for example, Wang U.S. Pat. No. 5,195,969, and Hamlin U.S. Pat. No. 5,270,086.
  • Suitable stents and stent delivery are also exemplified by the Express, Radius® or Symbio® systems, available from Boston Scientific Scimed, Maple Grove, Minn.
  • the stent can be of any desired shape and size (e.g., coronary stents, aortic stents, peripheral vascular stents, gastrointestinal stents, urology stents, and neurology stents).
  • the stent can have a diameter of between, for example, 1 mm to 46 mm.
  • a coronary stent can have an expanded diameter of from about 2 mm to about 6 mm.
  • a peripheral stent can have an expanded diameter of from about 5 mm to about 24 mm.
  • a gastrointestinal and/or urology stent can have an expanded diameter of from about 6 mm to about 30 mm.
  • a neurology stent can have an expanded diameter of from about 1 mm to about 12 mm.
  • An abdominal aortic aneurysm (AAA) stent and a thoracic aortic aneurysm (TAA) stent can have a diameter from about 20 mm to about 46 mm.
  • Stent 100 can be balloon-expandable, self-expandable, or a combination of both (e.g., U.S. Pat. No. 5,366,504).
  • the stent can also be a part of a stent-graft.
  • the stent includes and/or be attached to a biocompatible, non-porous or semi-porous polymer matrix made of polytetrafluoroethylene (PTFE), expanded PTFE, polyethylene, urethane, or polypropylene.
  • PTFE polytetrafluoroethylene
  • the endoprosthesis can include a releasable therapeutic agent, drug, or a pharmaceutically active compound, such as described in U.S. Pat. No. 5,674,242, U.S. Ser. No. 09/895,415, filed Jul. 2, 2001 and U.S. Ser. No. 10/232,265, filed Aug. 30, 2002.
  • the therapeutic agents, drugs, or pharmaceutically active compounds can include, for example, anti-thrombogenic agents, antioxidants, anti-inflammatory agents, anesthetic agents, anti-coagulants, and antibiotics.
  • the methods and the embodiments described above can be used to form medical devices other than stents and stent-grafts.
  • the methods and/or materials can be used to form filters, such as removable thrombus filters described in Kim et al., U.S. Pat. No. 6,146,404; in intravascular filters such as those described in Daniel et al., U.S. Pat. No. 6,171,327; and in vena cava filters such as those described in Soon et al., U.S. Pat. No. 6,342,062.
  • the methods and/or materials can be used to form guidewires, such as a Meier steerable guidewire.
  • the methods and/or materials can be used to form vaso-occlusive devices, e.g., coils, used to treat intravascular aneurysms, as described, e.g., in Bashiri et al., U.S. Pat. No. 6,468,266, and Wallace et al., U.S. Pat, No. 6,280,457.
  • the methods and/or materials can be used to form wire to make catheter reinforcement braid.
  • the methods and/or materials can also be used in surgical instruments, such as forceps, needles, clamps, and scalpels.
  • a titanium-tantalum alloy with a mass absorption coefficient of at least 1.96 cm 2 /g (iron) and as high as 2.86 cm 2 /g (half of tantalum) is formulated as follows.
  • the atomic mass coefficient for titanium is 1.21 and for tantalum is 5.72.
  • An alloy of 83 atomic percent Ti and 17 atomic percent Ta has a calculated mass absorption coefficient equivalent to iron and a radiopacity similar to 316L stainless steel.
  • An alloy of 63 atomic percent Ti and 37 atomic percent Ta has a calculated mass absorption coefficient equivalent to one-half of tantalum.
  • the alloy constituents have magnetic susceptibility less than 3.5 ⁇ 10 ⁇ 3 and are soluble in each other.
  • the tantalum-titanium binary phase diagram (ASM Handbook, Volume 3 Alloy Phase Diagrams, ASM International, 1992, p.
  • tantalum-titanium binary phase diagram indicates that the alloys with 43 to 69 percent tantalum concentration have alpha and beta phase microstructures. No brittle phases are evident in the phase diagram.
  • a titanium-molybdenum alloy with a mass absorption coefficient of at least 1.96 cm 2 /g (iron) and as high as 2.86 cm 2 /g (halfoftantalum) is formulated as follows.
  • An alloy of 87 atomic percent Ti and 13 atomic percent mo (77 weight percent Ti and 23 weight percent Mo) has a calculated mass absorption coefficient equivalent to iron and a radiopacity similar to 316L stainless steel.
  • An alloy of 72 atomic percent Ti and 28 atomic percent Mo (56 weight percent Ti and 44 weight percent Mo) has a calculated mass absorption coefficient equivalent to one-half of tantalum and therefore has half the radiopacity of tantalum.
  • the alloy constituents have magnetic susceptibility less than 3.5 ⁇ 10 ⁇ 3 and that are soluble in each other.
  • the molybdenum titanium binary phase diagram indicates (ASM Handbook, Volume 3 Alloy Phase Diagrams, ASM International, 1992, p.2.296) 23 to 44 weight percent molybdenum to be soluble in titanium as a solid solution single (beta) or two-phase (alpha and beta) material at room temperature.
  • the molybdenum-titanium binary phase diagram also indicates that alloys with 23 to 44 percent molybdenum concentration will have beta or beta plus alpha phase microstructures which are common in commercialized titanium engineering alloys such as Ti-6A1-4V. Cooling through the temperature range of about 850 to 695° C. can be performed rapidly (e.g., by argon gas, air cool, or liquid quenchant) to avoid precipitation of significant amounts of alpha-prime, alpha-double prime, or omega phases.
  • a method for making an alloy of Ti-6A1-4V ELI with 43 weight percent Ta follows.
  • Procure a 3′′ diameter round bar of Ti-6A1-4V ELI (such as form Titanium Industries, Inc. in Morristown, N.J.) and cut to 5.5 inches long.
  • Procure 0.5′′ diameter tantalum rod (such as from Rembar, Dobbs Ferry, N.Y.) and cut into lengths of 3.25′′.
  • Drill eight holes into the titanium bar that are 0.55/0.6′′ diameter and 4.5′′ deep. Put the eight 3.25′′ long pieces of 0.5′′ diameter tantalum rod into the holes. Heat the assembly in a vacuum furnace at 1400° C. for 8 hours and vacuum cool. Gas tungsten arc weld (GTAW or TIG) the assembly with the hole-end up to the vacuum arc remelt (VAR) electrode holder.
  • GTAW or TIG Gas tungsten arc weld
  • Arc melted Ti-Ta alloy button ingots were prepared. Two ingots were melted from a 50-50 mixture (by weight) of Ti-6A1-4V and tantalum rods. One ingot was melted from a 50-50 mixture (by weight) of pure titanium and tantalum rods. Cold rolling and annealing of the ingots were used to form strips for mechanical and physical property testing.
  • the ingots were prepared from the following rods and charge materials procured from Goodfellow Corporation, Berwyn, Pa. TABLE V Rods Material Traceability Ti—6Al—4V Goodfellow LS251817JV; TI017910/1, 5 mm dia ⁇ rods 200 mm long rods, 10 pcs, 174 g, annealed Ta rods Goodfellow LS251817JV, TA007920/8, 99.9% pure, 2 mm dia ⁇ 200 mm long rods, 5 pcs, 53.2 g, annealed Ti rods Goodfellow LS251817JV, TI007910/12, 2 mm dia ⁇ 100 mm long rods, 20 pcs, 28.5 g, 99.6% pure, annealed
  • Strip #1 had fine edge cracks.
  • Strip #2 had no cracks.
  • Strip #3 had edge cracks.
  • the cold rolled strips were annealed in the vacuum heat treat furnace at 1000° C. for 30 minutes in vacuum followed by a vacuum cool. The purpose of this heat treatment was to recrystallize the cold worked microstructure and soften the material to allow further cold rolling.
  • the strips were cold rolled to 0.025′′ thickness. The dimensions are given in Table X. TABLE X Dimension of Strips After Third Cold Rolling Campaign Bar # Length, inches Width, inches Thickness, inches 1 (Ti—Ta) 9 and 8 079 0.025 2 (Ti64—Ta) 10 0.88 0.025 3 (Ti64—Ta) 6 0.65 0.025
  • Strips #1 and #3 had many small edge cracks. Strip #2 did not have edge cracks.
  • the strips were beta solution treated in a vacuum heat treat furnace at 850° C. for 30 minutes and cooled in vacuum.
  • the strips were submitted for metallography.
  • the strips were subjected to tensile specimen machining and testing (Metcut Research Associates, Inc. (Cincinnati, Ohio)).
  • the tensile results were 85-115 ksi UTS, 65-105 YS, and 5-25% elongation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
US10/672,891 2003-09-26 2003-09-26 Medical devices and methods of making same Abandoned US20050070990A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US10/672,891 US20050070990A1 (en) 2003-09-26 2003-09-26 Medical devices and methods of making same
ES04784496T ES2375961T3 (es) 2003-09-26 2004-09-20 C�?nula endoluminal con balón expandible y métodos para hacer la misma.
EP04784496A EP1663071B1 (en) 2003-09-26 2004-09-20 Balloon-expendable stent and methods of making same
PCT/US2004/030645 WO2005030095A2 (en) 2003-09-26 2004-09-20 Balloon-expandable stent and methods of making same
JP2006528084A JP4921170B2 (ja) 2003-09-26 2004-09-20 バルーン拡張型ステント及びその製造方法並びにそのステントを有する物品
CA002539491A CA2539491A1 (en) 2003-09-26 2004-09-20 Balloon-expandable stent and methods of making same
AT04784496T ATE531340T1 (de) 2003-09-26 2004-09-20 Ballon-expandierbarer stent und herstellungsverfahren dafür
US12/643,629 US8137614B2 (en) 2003-09-26 2009-12-21 Medical devices and method for making the same
US13/396,085 US20120150276A1 (en) 2003-09-26 2012-02-14 Medical devices and method for making the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/672,891 US20050070990A1 (en) 2003-09-26 2003-09-26 Medical devices and methods of making same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/643,629 Continuation US8137614B2 (en) 2003-09-26 2009-12-21 Medical devices and method for making the same

Publications (1)

Publication Number Publication Date
US20050070990A1 true US20050070990A1 (en) 2005-03-31

Family

ID=34376494

Family Applications (3)

Application Number Title Priority Date Filing Date
US10/672,891 Abandoned US20050070990A1 (en) 2003-09-26 2003-09-26 Medical devices and methods of making same
US12/643,629 Expired - Fee Related US8137614B2 (en) 2003-09-26 2009-12-21 Medical devices and method for making the same
US13/396,085 Abandoned US20120150276A1 (en) 2003-09-26 2012-02-14 Medical devices and method for making the same

Family Applications After (2)

Application Number Title Priority Date Filing Date
US12/643,629 Expired - Fee Related US8137614B2 (en) 2003-09-26 2009-12-21 Medical devices and method for making the same
US13/396,085 Abandoned US20120150276A1 (en) 2003-09-26 2012-02-14 Medical devices and method for making the same

Country Status (7)

Country Link
US (3) US20050070990A1 (https=)
EP (1) EP1663071B1 (https=)
JP (1) JP4921170B2 (https=)
AT (1) ATE531340T1 (https=)
CA (1) CA2539491A1 (https=)
ES (1) ES2375961T3 (https=)
WO (1) WO2005030095A2 (https=)

Cited By (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050278929A1 (en) * 2004-06-16 2005-12-22 National Taipei University Technology Process of manufacturing stent with therapeutic function in the human body
US20060097242A1 (en) * 2004-11-10 2006-05-11 Mitsubishi Denki Kabushiki Kaisha Semiconductor light-emitting device
US20060122694A1 (en) * 2004-12-03 2006-06-08 Stinson Jonathan S Medical devices and methods of making the same
US20060222844A1 (en) * 2005-04-04 2006-10-05 Stinson Jonathan S Medical devices including composites
US20060251794A1 (en) * 2005-05-05 2006-11-09 Torsten Scheuermann Medical devices and methods of making the same
US20060259126A1 (en) * 2005-05-05 2006-11-16 Jason Lenz Medical devices and methods of making the same
US20060276875A1 (en) * 2005-05-27 2006-12-07 Stinson Jonathan S Medical devices
US20070009564A1 (en) * 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
US20070032861A1 (en) * 2005-08-08 2007-02-08 Boston Scientific Scimed, Inc. MRI resonator system with stent implant
US20070131318A1 (en) * 2005-12-12 2007-06-14 Accellent, Inc. Medical alloys with a non-alloyed dispersion and methods of making same
US20070239256A1 (en) * 2006-03-22 2007-10-11 Jan Weber Medical devices having electrical circuits with multilayer regions
US20080071344A1 (en) * 2006-09-18 2008-03-20 Boston Scientific Scimed, Inc. Medical device with porous surface
US20080069858A1 (en) * 2006-09-20 2008-03-20 Boston Scientific Scimed, Inc. Medical devices having biodegradable polymeric regions with overlying hard, thin layers
US20080071355A1 (en) * 2006-09-14 2008-03-20 Boston Scientific Scimed, Inc. Medical Devices with Drug-Eluting Coating
US20080071352A1 (en) * 2006-09-15 2008-03-20 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
US20080071351A1 (en) * 2006-09-15 2008-03-20 Boston Scientific Scimed, Inc. Endoprosthesis with adjustable surface features
US20080097577A1 (en) * 2006-10-20 2008-04-24 Boston Scientific Scimed, Inc. Medical device hydrogen surface treatment by electrochemical reduction
US20080095919A1 (en) * 2006-10-23 2008-04-24 Mcclain James B Holder For Electrically Charging A Substrate During Coating
US20080132998A1 (en) * 2004-09-29 2008-06-05 Alveolus, Inc. Active stent
US20080131479A1 (en) * 2006-08-02 2008-06-05 Jan Weber Endoprosthesis with three-dimensional disintegration control
US20080147177A1 (en) * 2006-11-09 2008-06-19 Torsten Scheuermann Endoprosthesis with coatings
US20080161900A1 (en) * 2006-06-20 2008-07-03 Boston Scientific Scimed, Inc. Medical devices including composites
US20080160259A1 (en) * 2006-12-28 2008-07-03 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US20080195194A1 (en) * 2007-02-13 2008-08-14 Abbott Cardiovascular Systems Inc. Mri compatible, radiopaque alloys for use in medical devices
US20090024199A1 (en) * 2007-07-16 2009-01-22 Medtronic Vascular, Inc. Controlled Porosity Stent
US20090118814A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118821A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
US20090149942A1 (en) * 2007-07-19 2009-06-11 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US20090186069A1 (en) * 2006-04-26 2009-07-23 Micell Technologies, Inc. Coatings Containing Multiple Drugs
US20090285714A1 (en) * 2008-05-19 2009-11-19 Pulse Technologies, Inc. Implantable medical Devices Composed of a Radiopaque Alloy and Method of Making the Alloy
US20090292351A1 (en) * 2008-04-17 2009-11-26 Micell Technologies, Inc. Stents having bioabsorbable layers
US20090299468A1 (en) * 2008-05-29 2009-12-03 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090319032A1 (en) * 2008-06-18 2009-12-24 Boston Scientific Scimed, Inc Endoprosthesis coating
US20100010620A1 (en) * 2008-07-09 2010-01-14 Boston Scientific Scimed, Inc. Stent
US20100015200A1 (en) * 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug Delivery Medical Device
US20100057188A1 (en) * 2008-08-28 2010-03-04 Boston Scientific Scimed, Inc. Endoprostheses with porous regions and non-polymeric coating
US20100063584A1 (en) * 2008-09-05 2010-03-11 Boston Scientific Scimed, Inc. Endoprostheses
US20100063580A1 (en) * 2007-01-08 2010-03-11 Mcclain James B Stents having biodegradable layers
US20100211164A1 (en) * 2007-04-17 2010-08-19 Mcclain James B Stents having biodegradable layers
US7780798B2 (en) 2006-10-13 2010-08-24 Boston Scientific Scimed, Inc. Medical devices including hardened alloys
US20100239635A1 (en) * 2009-03-23 2010-09-23 Micell Technologies, Inc. Drug delivery medical device
US20100241220A1 (en) * 2009-03-23 2010-09-23 Mcclain James B Peripheral Stents Having Layers
US20100256748A1 (en) * 2009-04-01 2010-10-07 Micell Technologies, Inc. Coated stents
US20100256718A1 (en) * 2009-04-06 2010-10-07 Medtronic, Inc. Wire Configuration and Method of Making for an Implantable Medical Apparatus
US20100272778A1 (en) * 2007-04-17 2010-10-28 Micell Technologies, Inc. Stents having controlled elution
US20100298928A1 (en) * 2007-10-19 2010-11-25 Micell Technologies, Inc. Drug Coated Stents
US20110022162A1 (en) * 2009-07-23 2011-01-27 Boston Scientific Scimed, Inc. Endoprostheses
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20110159069A1 (en) * 2008-12-26 2011-06-30 Shaw Wendy J Medical Implants and Methods of Making Medical Implants
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US20110190864A1 (en) * 2010-02-02 2011-08-04 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20110238161A1 (en) * 2010-03-26 2011-09-29 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US20110238153A1 (en) * 2010-03-26 2011-09-29 Boston Scientific Scimed, Inc. Endoprostheses
US20110238149A1 (en) * 2010-03-26 2011-09-29 Boston Scientific Scimed, Inc. Endoprosthesis
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8052744B2 (en) 2006-09-15 2011-11-08 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US8057534B2 (en) 2006-09-15 2011-11-15 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US8066763B2 (en) 1998-04-11 2011-11-29 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8080055B2 (en) 2006-12-28 2011-12-20 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
WO2012142319A1 (en) 2011-04-13 2012-10-18 Micell Technologies, Inc. Stents having controlled elution
US8303643B2 (en) 2001-06-27 2012-11-06 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US8340759B2 (en) 2011-04-22 2012-12-25 Medtronic, Inc. Large-pitch coil configurations for a medical device
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8574615B2 (en) 2006-03-24 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8660662B2 (en) 2011-04-22 2014-02-25 Medtronic, Inc. Low impedance, low modulus wire configurations for a medical device
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US8758429B2 (en) 2005-07-15 2014-06-24 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
US8808726B2 (en) 2006-09-15 2014-08-19 Boston Scientific Scimed. Inc. Bioerodible endoprostheses and methods of making the same
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8834560B2 (en) 2010-04-06 2014-09-16 Boston Scientific Scimed, Inc. Endoprosthesis
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8900651B2 (en) 2007-05-25 2014-12-02 Micell Technologies, Inc. Polymer films for medical device coating
US8920490B2 (en) 2010-05-13 2014-12-30 Boston Scientific Scimed, Inc. Endoprostheses
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US20150182324A1 (en) * 2005-06-10 2015-07-02 Keystone Heart Ltd. Implant device particularly useful for implantation in the intravascular system for diverting emboli
US9409008B2 (en) 2011-04-22 2016-08-09 Medtronic, Inc. Cable configurations for a medical device
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
US9668849B2 (en) 2001-12-05 2017-06-06 Keystone Heart Ltd. Endovascular device for entrapment of participate matter and method for use
US9987130B2 (en) 2011-12-13 2018-06-05 Boston Scientific Scimed, Inc. Decalcifying heart valve
US20180258512A1 (en) * 2015-09-17 2018-09-13 Nanyang Technological University Titanium-tantalum alloy and method of forming thereof
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US10272606B2 (en) 2013-05-15 2019-04-30 Micell Technologies, Inc. Bioabsorbable biomedical implants
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US10835396B2 (en) 2005-07-15 2020-11-17 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
US11039943B2 (en) 2013-03-12 2021-06-22 Micell Technologies, Inc. Bioabsorbable biomedical implants
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
US20230277733A1 (en) * 2019-09-11 2023-09-07 Stryker Corporation Intravascular devices
US11904118B2 (en) 2010-07-16 2024-02-20 Micell Medtech Inc. Drug delivery medical device

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008036076A (ja) * 2006-08-04 2008-02-21 Japan Health Science Foundation バルーン拡張型ステントおよびその製造方法
DE102007031796A1 (de) * 2007-07-07 2009-01-08 WRW Consulting GbR (Vertretungsberechtigter Gesellschafter: Dr. Walter Reith, 66424 Homburg) Radial expandierbares System für den Einsatz in Körperröhren
US20110303553A1 (en) * 2010-06-11 2011-12-15 Inman Maria E Electrochemical system and method for machining strongly passivating metals
WO2012094604A2 (en) * 2011-01-06 2012-07-12 Purdue Research Foundation Large strain extrusion machining processes and bulk forms produced therefrom
JP2013181190A (ja) 2012-02-29 2013-09-12 Seiko Instruments Inc 生体用Ｃｏ基合金およびステント
US9006147B2 (en) * 2012-07-11 2015-04-14 Faraday Technology, Inc. Electrochemical system and method for electropolishing superconductive radio frequency cavities

Citations (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161503A (en) * 1961-09-27 1964-12-15 Titanium Metals Corp Corrosion resistant alloy
US4040129A (en) * 1970-07-15 1977-08-09 Institut Dr. Ing. Reinhard Straumann Ag Surgical implant and alloy for use in making an implant
US5047030A (en) * 1987-02-20 1991-09-10 Klaus Draenert Suction drainage-bone screw
US5169597A (en) * 1989-12-21 1992-12-08 Davidson James A Biocompatible low modulus titanium alloy for medical implants
US5195969A (en) * 1991-04-26 1993-03-23 Boston Scientific Corporation Co-extruded medical balloons and catheter using such balloons
US5270086A (en) * 1989-09-25 1993-12-14 Schneider (Usa) Inc. Multilayer extrusion of angioplasty balloons
US5366504A (en) * 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
US5545227A (en) * 1989-12-21 1996-08-13 Smith & Nephew Richards, Inc. Biocompatible low modulus medical implants
US5643312A (en) * 1994-02-25 1997-07-01 Fischell Robert Stent having a multiplicity of closed circular structures
US5653727A (en) * 1987-10-19 1997-08-05 Medtronic, Inc. Intravascular stent
US5685306A (en) * 1989-12-21 1997-11-11 Smith & Nephew, Inc. Flexible, biocompatible, metal alloy catheter
US5728158A (en) * 1991-10-28 1998-03-17 Advanced Cardiovascular Systems, Inc. Expandable stents
US5780807A (en) * 1994-11-28 1998-07-14 Advanced Cardiovascular Systems, Inc. Method and apparatus for direct laser cutting of metal stents
US5888201A (en) * 1996-02-08 1999-03-30 Schneider (Usa) Inc Titanium alloy self-expanding stent
US5954724A (en) * 1997-03-27 1999-09-21 Davidson; James A. Titanium molybdenum hafnium alloys for medical implants and devices
US5972027A (en) * 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6027528A (en) * 1996-05-28 2000-02-22 Cordis Corporation Composite material endoprosthesis
US6146404A (en) * 1999-09-03 2000-11-14 Scimed Life Systems, Inc. Removable thrombus filter
US6171327B1 (en) * 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6258182B1 (en) * 1998-03-05 2001-07-10 Memry Corporation Pseudoelastic β titanium alloy and uses therefor
US6280457B1 (en) * 1999-06-04 2001-08-28 Scimed Life Systems, Inc. Polymer covered vaso-occlusive devices and methods of producing such devices
US6342062B1 (en) * 1998-09-24 2002-01-29 Scimed Life Systems, Inc. Retrieval devices for vena cava filter
US6375458B1 (en) * 1999-05-17 2002-04-23 Memry Corporation Medical instruments and devices and parts thereof using shape memory alloys
US6409852B1 (en) * 1999-01-07 2002-06-25 Jiin-Huey Chern Biocompatible low modulus titanium alloy for medical implant
US6468266B1 (en) * 1997-08-29 2002-10-22 Scimed Life Systems, Inc. Fast detaching electrically isolated implant
US20030003220A1 (en) * 2001-07-02 2003-01-02 Sheng-Ping Zhong Coating a medical appliance with a bubble jet printing head
US20030185895A1 (en) * 2002-03-29 2003-10-02 Janel Lanphere Drug delivery particle
US20040143317A1 (en) * 2003-01-17 2004-07-22 Stinson Jonathan S. Medical devices

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549429A (en) * 1968-08-27 1970-12-22 Surface Technology Corp Wear and abrasion resistant materials
US4857269A (en) * 1988-09-09 1989-08-15 Pfizer Hospital Products Group Inc. High strength, low modulus, ductile, biopcompatible titanium alloy
US4994071A (en) * 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
US5232361A (en) * 1992-04-06 1993-08-03 Sachdeva Rohit C L Orthodontic bracket
US5843168A (en) * 1997-03-31 1998-12-01 Medtronic, Inc. Double wave stent with strut
GB9806085D0 (en) * 1998-03-23 1998-05-20 Xerox Corp Text summarisation using light syntactic parsing
NL1011779C2 (nl) * 1999-04-13 2000-10-16 Elephant Dental Bv Biomedisch hulpmiddel of implantaat.
US6767418B1 (en) * 1999-04-23 2004-07-27 Terumo Kabushiki Kaisha Ti-Zr type alloy and medical appliance formed thereof
US6402859B1 (en) * 1999-09-10 2002-06-11 Terumo Corporation β-titanium alloy wire, method for its production and medical instruments made by said β-titanium alloy wire
US20030018380A1 (en) * 2000-07-07 2003-01-23 Craig Charles H. Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom

Patent Citations (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161503A (en) * 1961-09-27 1964-12-15 Titanium Metals Corp Corrosion resistant alloy
US4040129A (en) * 1970-07-15 1977-08-09 Institut Dr. Ing. Reinhard Straumann Ag Surgical implant and alloy for use in making an implant
US5047030A (en) * 1987-02-20 1991-09-10 Klaus Draenert Suction drainage-bone screw
US5653727A (en) * 1987-10-19 1997-08-05 Medtronic, Inc. Intravascular stent
US5270086A (en) * 1989-09-25 1993-12-14 Schneider (Usa) Inc. Multilayer extrusion of angioplasty balloons
US5685306A (en) * 1989-12-21 1997-11-11 Smith & Nephew, Inc. Flexible, biocompatible, metal alloy catheter
US5169597A (en) * 1989-12-21 1992-12-08 Davidson James A Biocompatible low modulus titanium alloy for medical implants
US5545227A (en) * 1989-12-21 1996-08-13 Smith & Nephew Richards, Inc. Biocompatible low modulus medical implants
US5690670A (en) * 1989-12-21 1997-11-25 Davidson; James A. Stents of enhanced biocompatibility and hemocompatibility
US5195969A (en) * 1991-04-26 1993-03-23 Boston Scientific Corporation Co-extruded medical balloons and catheter using such balloons
US5728158A (en) * 1991-10-28 1998-03-17 Advanced Cardiovascular Systems, Inc. Expandable stents
US5366504A (en) * 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
US5643312A (en) * 1994-02-25 1997-07-01 Fischell Robert Stent having a multiplicity of closed circular structures
US5780807A (en) * 1994-11-28 1998-07-14 Advanced Cardiovascular Systems, Inc. Method and apparatus for direct laser cutting of metal stents
US5888201A (en) * 1996-02-08 1999-03-30 Schneider (Usa) Inc Titanium alloy self-expanding stent
US6027528A (en) * 1996-05-28 2000-02-22 Cordis Corporation Composite material endoprosthesis
US5954724A (en) * 1997-03-27 1999-09-21 Davidson; James A. Titanium molybdenum hafnium alloys for medical implants and devices
US6200685B1 (en) * 1997-03-27 2001-03-13 James A. Davidson Titanium molybdenum hafnium alloy
US6468266B1 (en) * 1997-08-29 2002-10-22 Scimed Life Systems, Inc. Fast detaching electrically isolated implant
US5972027A (en) * 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6258182B1 (en) * 1998-03-05 2001-07-10 Memry Corporation Pseudoelastic β titanium alloy and uses therefor
US6342062B1 (en) * 1998-09-24 2002-01-29 Scimed Life Systems, Inc. Retrieval devices for vena cava filter
US6409852B1 (en) * 1999-01-07 2002-06-25 Jiin-Huey Chern Biocompatible low modulus titanium alloy for medical implant
US6171327B1 (en) * 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6375458B1 (en) * 1999-05-17 2002-04-23 Memry Corporation Medical instruments and devices and parts thereof using shape memory alloys
US6280457B1 (en) * 1999-06-04 2001-08-28 Scimed Life Systems, Inc. Polymer covered vaso-occlusive devices and methods of producing such devices
US6146404A (en) * 1999-09-03 2000-11-14 Scimed Life Systems, Inc. Removable thrombus filter
US20030003220A1 (en) * 2001-07-02 2003-01-02 Sheng-Ping Zhong Coating a medical appliance with a bubble jet printing head
US20030185895A1 (en) * 2002-03-29 2003-10-02 Janel Lanphere Drug delivery particle
US20040143317A1 (en) * 2003-01-17 2004-07-22 Stinson Jonathan S. Medical devices

Cited By (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8066763B2 (en) 1998-04-11 2011-11-29 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US8303643B2 (en) 2001-06-27 2012-11-06 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US10624732B2 (en) 2001-12-05 2020-04-21 Keystone Heart Ltd. Endovascular device for entrapment of participate matter and method for use
US9668849B2 (en) 2001-12-05 2017-06-06 Keystone Heart Ltd. Endovascular device for entrapment of participate matter and method for use
US20050278929A1 (en) * 2004-06-16 2005-12-22 National Taipei University Technology Process of manufacturing stent with therapeutic function in the human body
US20080132998A1 (en) * 2004-09-29 2008-06-05 Alveolus, Inc. Active stent
US7887579B2 (en) * 2004-09-29 2011-02-15 Merit Medical Systems, Inc. Active stent
US20060097242A1 (en) * 2004-11-10 2006-05-11 Mitsubishi Denki Kabushiki Kaisha Semiconductor light-emitting device
US20060122694A1 (en) * 2004-12-03 2006-06-08 Stinson Jonathan S Medical devices and methods of making the same
US20060222844A1 (en) * 2005-04-04 2006-10-05 Stinson Jonathan S Medical devices including composites
US7641983B2 (en) 2005-04-04 2010-01-05 Boston Scientific Scimed, Inc. Medical devices including composites
US20060251794A1 (en) * 2005-05-05 2006-11-09 Torsten Scheuermann Medical devices and methods of making the same
US8071155B2 (en) 2005-05-05 2011-12-06 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US20060259126A1 (en) * 2005-05-05 2006-11-16 Jason Lenz Medical devices and methods of making the same
US20090214373A1 (en) * 2005-05-27 2009-08-27 Boston Scientific Scimed, Inc. Medical Devices
US20060276875A1 (en) * 2005-05-27 2006-12-07 Stinson Jonathan S Medical devices
US20150182324A1 (en) * 2005-06-10 2015-07-02 Keystone Heart Ltd. Implant device particularly useful for implantation in the intravascular system for diverting emboli
US20070009564A1 (en) * 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
US8758429B2 (en) 2005-07-15 2014-06-24 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US10898353B2 (en) 2005-07-15 2021-01-26 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US9827117B2 (en) 2005-07-15 2017-11-28 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US11911301B2 (en) 2005-07-15 2024-02-27 Micell Medtech Inc. Polymer coatings containing drug powder of controlled morphology
US10835396B2 (en) 2005-07-15 2020-11-17 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
US7778684B2 (en) 2005-08-08 2010-08-17 Boston Scientific Scimed, Inc. MRI resonator system with stent implant
US20070032861A1 (en) * 2005-08-08 2007-02-08 Boston Scientific Scimed, Inc. MRI resonator system with stent implant
US20070032862A1 (en) * 2005-08-08 2007-02-08 Jan Weber Medical devices
US20070131318A1 (en) * 2005-12-12 2007-06-14 Accellent, Inc. Medical alloys with a non-alloyed dispersion and methods of making same
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070239256A1 (en) * 2006-03-22 2007-10-11 Jan Weber Medical devices having electrical circuits with multilayer regions
US8574615B2 (en) 2006-03-24 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US9737645B2 (en) 2006-04-26 2017-08-22 Micell Technologies, Inc. Coatings containing multiple drugs
US11007307B2 (en) 2006-04-26 2021-05-18 Micell Technologies, Inc. Coatings containing multiple drugs
US9415142B2 (en) 2006-04-26 2016-08-16 Micell Technologies, Inc. Coatings containing multiple drugs
US20090186069A1 (en) * 2006-04-26 2009-07-23 Micell Technologies, Inc. Coatings Containing Multiple Drugs
US11850333B2 (en) 2006-04-26 2023-12-26 Micell Medtech Inc. Coatings containing multiple drugs
US8852625B2 (en) 2006-04-26 2014-10-07 Micell Technologies, Inc. Coatings containing multiple drugs
US20080161900A1 (en) * 2006-06-20 2008-07-03 Boston Scientific Scimed, Inc. Medical devices including composites
US9011516B2 (en) 2006-06-20 2015-04-21 Boston Scientific Scimed, Inc. Medical devices including composites
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
US20080131479A1 (en) * 2006-08-02 2008-06-05 Jan Weber Endoprosthesis with three-dimensional disintegration control
US8052743B2 (en) 2006-08-02 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
US20080071355A1 (en) * 2006-09-14 2008-03-20 Boston Scientific Scimed, Inc. Medical Devices with Drug-Eluting Coating
US8353949B2 (en) 2006-09-14 2013-01-15 Boston Scientific Scimed, Inc. Medical devices with drug-eluting coating
US20080071352A1 (en) * 2006-09-15 2008-03-20 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
US7955382B2 (en) 2006-09-15 2011-06-07 Boston Scientific Scimed, Inc. Endoprosthesis with adjustable surface features
US8808726B2 (en) 2006-09-15 2014-08-19 Boston Scientific Scimed. Inc. Bioerodible endoprostheses and methods of making the same
US8052744B2 (en) 2006-09-15 2011-11-08 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US8057534B2 (en) 2006-09-15 2011-11-15 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8128689B2 (en) 2006-09-15 2012-03-06 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
US20080071351A1 (en) * 2006-09-15 2008-03-20 Boston Scientific Scimed, Inc. Endoprosthesis with adjustable surface features
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
US20080071344A1 (en) * 2006-09-18 2008-03-20 Boston Scientific Scimed, Inc. Medical device with porous surface
US20080069858A1 (en) * 2006-09-20 2008-03-20 Boston Scientific Scimed, Inc. Medical devices having biodegradable polymeric regions with overlying hard, thin layers
US7780798B2 (en) 2006-10-13 2010-08-24 Boston Scientific Scimed, Inc. Medical devices including hardened alloys
US20080097577A1 (en) * 2006-10-20 2008-04-24 Boston Scientific Scimed, Inc. Medical device hydrogen surface treatment by electrochemical reduction
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US20080095919A1 (en) * 2006-10-23 2008-04-24 Mcclain James B Holder For Electrically Charging A Substrate During Coating
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US20080147177A1 (en) * 2006-11-09 2008-06-19 Torsten Scheuermann Endoprosthesis with coatings
US8080055B2 (en) 2006-12-28 2011-12-20 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US9034456B2 (en) 2006-12-28 2015-05-19 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US20080160259A1 (en) * 2006-12-28 2008-07-03 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US8715339B2 (en) 2006-12-28 2014-05-06 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20100063580A1 (en) * 2007-01-08 2010-03-11 Mcclain James B Stents having biodegradable layers
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
US9737642B2 (en) 2007-01-08 2017-08-22 Micell Technologies, Inc. Stents having biodegradable layers
US10617795B2 (en) 2007-01-08 2020-04-14 Micell Technologies, Inc. Stents having biodegradable layers
US20080195194A1 (en) * 2007-02-13 2008-08-14 Abbott Cardiovascular Systems Inc. Mri compatible, radiopaque alloys for use in medical devices
WO2008100852A3 (en) * 2007-02-13 2009-12-03 Abbott Cardiovascular Systems Inc. Mri compatible, radiopaque alloys for use in medical devices
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US20100272778A1 (en) * 2007-04-17 2010-10-28 Micell Technologies, Inc. Stents having controlled elution
US9775729B2 (en) 2007-04-17 2017-10-03 Micell Technologies, Inc. Stents having controlled elution
US20100211164A1 (en) * 2007-04-17 2010-08-19 Mcclain James B Stents having biodegradable layers
US9486338B2 (en) 2007-04-17 2016-11-08 Micell Technologies, Inc. Stents having controlled elution
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8900651B2 (en) 2007-05-25 2014-12-02 Micell Technologies, Inc. Polymer films for medical device coating
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20110224783A1 (en) * 2007-07-11 2011-09-15 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8790392B2 (en) 2007-07-11 2014-07-29 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8205317B2 (en) * 2007-07-16 2012-06-26 Medtronic Vascular, Inc. Method of manufacturing a controlled porosity stent
US20090024199A1 (en) * 2007-07-16 2009-01-22 Medtronic Vascular, Inc. Controlled Porosity Stent
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US20090149942A1 (en) * 2007-07-19 2009-06-11 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20100298928A1 (en) * 2007-10-19 2010-11-25 Micell Technologies, Inc. Drug Coated Stents
US20090118814A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118821A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US20090292351A1 (en) * 2008-04-17 2009-11-26 Micell Technologies, Inc. Stents having bioabsorbable layers
US9789233B2 (en) 2008-04-17 2017-10-17 Micell Technologies, Inc. Stents having bioabsorbable layers
US10350333B2 (en) 2008-04-17 2019-07-16 Micell Technologies, Inc. Stents having bioabsorable layers
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
WO2009142780A1 (en) * 2008-05-19 2009-11-26 Pulse Technolgies, Inc. Implantable medical devices composed of a radiopaque alloy and method making the alloy
US20090285714A1 (en) * 2008-05-19 2009-11-19 Pulse Technologies, Inc. Implantable medical Devices Composed of a Radiopaque Alloy and Method of Making the Alloy
US20090299468A1 (en) * 2008-05-29 2009-12-03 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090319032A1 (en) * 2008-06-18 2009-12-24 Boston Scientific Scimed, Inc Endoprosthesis coating
US9078777B2 (en) 2008-07-09 2015-07-14 Boston Scientific Scimed, Inc. Stent with non-round cross-section in an unexpanded state
US20100010620A1 (en) * 2008-07-09 2010-01-14 Boston Scientific Scimed, Inc. Stent
US10350391B2 (en) 2008-07-17 2019-07-16 Micell Technologies, Inc. Drug delivery medical device
US20100015200A1 (en) * 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug Delivery Medical Device
US9486431B2 (en) 2008-07-17 2016-11-08 Micell Technologies, Inc. Drug delivery medical device
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
US9981071B2 (en) 2008-07-17 2018-05-29 Micell Technologies, Inc. Drug delivery medical device
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US20100057188A1 (en) * 2008-08-28 2010-03-04 Boston Scientific Scimed, Inc. Endoprostheses with porous regions and non-polymeric coating
US8114153B2 (en) 2008-09-05 2012-02-14 Boston Scientific Scimed, Inc. Endoprostheses
US20100063584A1 (en) * 2008-09-05 2010-03-11 Boston Scientific Scimed, Inc. Endoprostheses
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US20110159069A1 (en) * 2008-12-26 2011-06-30 Shaw Wendy J Medical Implants and Methods of Making Medical Implants
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US20100239635A1 (en) * 2009-03-23 2010-09-23 Micell Technologies, Inc. Drug delivery medical device
US20100241220A1 (en) * 2009-03-23 2010-09-23 Mcclain James B Peripheral Stents Having Layers
US9981072B2 (en) 2009-04-01 2018-05-29 Micell Technologies, Inc. Coated stents
US10653820B2 (en) 2009-04-01 2020-05-19 Micell Technologies, Inc. Coated stents
US20100256748A1 (en) * 2009-04-01 2010-10-07 Micell Technologies, Inc. Coated stents
US8639352B2 (en) 2009-04-06 2014-01-28 Medtronic, Inc. Wire configuration and method of making for an implantable medical apparatus
US20100256718A1 (en) * 2009-04-06 2010-10-07 Medtronic, Inc. Wire Configuration and Method of Making for an Implantable Medical Apparatus
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20110022162A1 (en) * 2009-07-23 2011-01-27 Boston Scientific Scimed, Inc. Endoprostheses
US11369498B2 (en) 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
US20110190864A1 (en) * 2010-02-02 2011-08-04 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US20110238153A1 (en) * 2010-03-26 2011-09-29 Boston Scientific Scimed, Inc. Endoprostheses
US8895099B2 (en) 2010-03-26 2014-11-25 Boston Scientific Scimed, Inc. Endoprosthesis
US20110238149A1 (en) * 2010-03-26 2011-09-29 Boston Scientific Scimed, Inc. Endoprosthesis
US9687864B2 (en) 2010-03-26 2017-06-27 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US20110238161A1 (en) * 2010-03-26 2011-09-29 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US8834560B2 (en) 2010-04-06 2014-09-16 Boston Scientific Scimed, Inc. Endoprosthesis
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US8920490B2 (en) 2010-05-13 2014-12-30 Boston Scientific Scimed, Inc. Endoprostheses
US11904118B2 (en) 2010-07-16 2024-02-20 Micell Medtech Inc. Drug delivery medical device
WO2012142319A1 (en) 2011-04-13 2012-10-18 Micell Technologies, Inc. Stents having controlled elution
US8660662B2 (en) 2011-04-22 2014-02-25 Medtronic, Inc. Low impedance, low modulus wire configurations for a medical device
US8340759B2 (en) 2011-04-22 2012-12-25 Medtronic, Inc. Large-pitch coil configurations for a medical device
US9409008B2 (en) 2011-04-22 2016-08-09 Medtronic, Inc. Cable configurations for a medical device
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US10729819B2 (en) 2011-07-15 2020-08-04 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
US11357623B2 (en) 2011-12-13 2022-06-14 Boston Scientific Scimed, Inc. Decalcifying heart valve
US9987130B2 (en) 2011-12-13 2018-06-05 Boston Scientific Scimed, Inc. Decalcifying heart valve
US11039943B2 (en) 2013-03-12 2021-06-22 Micell Technologies, Inc. Bioabsorbable biomedical implants
US10272606B2 (en) 2013-05-15 2019-04-30 Micell Technologies, Inc. Bioabsorbable biomedical implants
US20180258512A1 (en) * 2015-09-17 2018-09-13 Nanyang Technological University Titanium-tantalum alloy and method of forming thereof
US20230277733A1 (en) * 2019-09-11 2023-09-07 Stryker Corporation Intravascular devices
US12133934B2 (en) * 2019-09-11 2024-11-05 Stryker Corporation Intravascular devices
US12194199B2 (en) 2019-09-11 2025-01-14 Stryker Corporation Intravascular devices
US12280181B2 (en) 2019-09-11 2025-04-22 Stryker Corporation Intravascular devices

Also Published As

Publication number Publication date
CA2539491A1 (en) 2005-04-07
JP4921170B2 (ja) 2012-04-25
ES2375961T3 (es) 2012-03-07
US8137614B2 (en) 2012-03-20
WO2005030095A3 (en) 2005-07-14
US20120150276A1 (en) 2012-06-14
WO2005030095A2 (en) 2005-04-07
JP2007517536A (ja) 2007-07-05
US20100228334A1 (en) 2010-09-09
EP1663071B1 (en) 2011-11-02
EP1663071A2 (en) 2006-06-07
ATE531340T1 (de) 2011-11-15

Similar Documents

Publication Publication Date Title
US8137614B2 (en) Medical devices and method for making the same
US7938854B2 (en) Medical devices and methods of making the same
US9402936B2 (en) Medical devices having alloy compositions
US7780798B2 (en) Medical devices including hardened alloys
US20090222079A1 (en) Medical devices having alloy compositions
EP1866006B1 (en) Medical devices including composites
EP1604691B1 (en) Biocompatible alloy for implantable medical devices
EP1604692B1 (en) Cobalt-nickel-chromium biocompatible alloy for implantable medical devices
US7794493B2 (en) Magnetic resonance imaging compatibility alloy for implantable medical devices
WO2023239573A1 (en) Processing of cobalt-tungsten alloys

Legal Events

Date Code Title Description
AS Assignment

Owner name: SCIMED LIFE SYSTEMS, INC., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:STINSON, JONATHAN S.;REEL/FRAME:014555/0763

Effective date: 20030922

AS Assignment

Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA

Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:018505/0868

Effective date: 20050101

Owner name: BOSTON SCIENTIFIC SCIMED, INC.,MINNESOTA

Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:018505/0868

Effective date: 20050101

STCB Information on status: application discontinuation

Free format text: ABANDONED -- AFTER EXAMINER'S ANSWER OR BOARD OF APPEALS DECISION