US20050008579A1 - Deactivants for dust mite allergens - Google Patents
Deactivants for dust mite allergens Download PDFInfo
- Publication number
- US20050008579A1 US20050008579A1 US10/911,895 US91189504A US2005008579A1 US 20050008579 A1 US20050008579 A1 US 20050008579A1 US 91189504 A US91189504 A US 91189504A US 2005008579 A1 US2005008579 A1 US 2005008579A1
- Authority
- US
- United States
- Prior art keywords
- der
- allergen
- deactivant
- amount
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000000034 method Methods 0.000 claims description 15
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- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 229930007110 thujone Natural products 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical group CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
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- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
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- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
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- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
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- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/06—Coniferophyta [gymnosperms], e.g. cypress
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
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Definitions
- Der-f Dermatophagoides farinae
- Der-p Dermatophagoides pteronyssinus
- Der-f and Der-p species are found throughout the world. In some areas, Der-f will be the sole Dermatophagoides species. In other areas Der-p will be the sole species. In still other areas, the two species are both present through, generally, one or the other will predominate.
- a method for deactivating allergens derived from the Der-f and/or Der-p dust mite species which comprises contacting the allergen with a deactivating effective amount of one or more of deactivants (herein after defined as the deactivant).
- a compound of formula I is commercially available as Aerosol OT.
- the compound of formula II is commercially available as parsley camphor.
- Hinoki oil is a mixture of thujan-3-one, 2-pinene, 3,5,7,3′,4′-pentahydroflavanone and 1,3,3-trimethyl-2-norcamphanone.
- Hydrogenated Hop Oil is the potassium salt of tetrahydroiso humulinic acid (also known as reduced isomerised hop extract).
- Chlorohexadine is 1,1′-hexamnethylenebis [5-(4-chlorophenyl)]-biguanide.
- Hinokitol is ⁇ -thujaplicin, a compound of the formula
- Germall II is diazolidinylurea.
- Thymol is 6-isopropyl-m-cresol.
- Cedarwood oil contains ⁇ - and ⁇ -cedrene (ca 80%), cedrol (3-14%) and cedrenol. Other sesquiterpenes and some monoterpenes are also present.
- Polyquaternium-10 is a polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with a trimethyl ammonium substituted epoxide commercially available as Polymer JR-125.
- Silica gel is also known as colloidal silica or silicic acid and is commercially available as Kent.
- Immobilised tannic acid is tannic acid on polyvinyl pyrrolidone beads. Immobilised Tannic Acid was prepared as follows: 100 mg of tannic acid was dissolved in water; 50 mg of Polyclar 10 (ISP, Guildford Surrey) polyvinyl pyrrolidone beads were added and stirred for one hour; the beads were filtered off the solution and washed with a few mls of iced water until no colour was seen in the washings; they were then dried in the oven at 50° C.
- the composite of silver chloride and TiO 2 is made up of 20% wt/wt AgCl on 80% TiO 2 3-5 ⁇ m porous beads.
- the deactivant is present in an amount of from 0.01% to 7%, preferably from 0.01% to 3%.
- the amount of deactivant present is from about 16 gm to about 170 gm per 10 square meters, preferably about 32 gm per 10 square meters.
- the deactivant is selected from:
- the amount of deactivant present in such a composition is from 0.01% to 7%, more preferably 0.01% to 3%,
- the amount of propellant present in such a composition is from 4% to 50%, more preferably from 4% to 30%,
- the amount of solvent present in such a composition is 0% to 99.95%, more preferably 0% to 90%, and most preferably from 20% to 90%.
- the deactivant in such aerosol composition is selected from:
- the propellant is selected from those commercially available, for example C 1-4 alkanes, chlorofluorocarbons and compressed gases such as nitrogen, air and carbon dioxide.
- the solvent is selected from C 1-6 alcohols (e.g. ethanol) or water.
- compositions of this invention may also contain one or more of the following:
- deactivants of the invention have as effective allergen deactivating properties as tannic acid but without the drawback of staining.
- test procedure in Examples 1 to 55 is as follows and is known as the ELISA protocol.
- the ELISA protocol for Der-f and Der-p has been developed as follows as a measure of denaturing property for denaturants.
- Dust is collected from HooverTM vacuum cleaner bags and passed through a series of sieves down to 63 microns.
- Filter paper is used to line each dish and 0.2 g of dust is added to each dish onto the filter paper.
- the lid (or base, as dishes are inverted) is replaced and the dish is shaken to disperse the dust evenly over the filter paper.
- Monoclonal antibody (kept in the freezer) has to be added to the buffer using the following method, (1 ⁇ g per well; 11 ml is needed) applied to the ELISA plate
- the deactivants as set out in the following table, were used against Der-f allergens according to the above procedure and the results are as given below. Tannic acid was used as a comparator. What was measured after treatment with deactivant and tannic acid was the amount of allergen remaining active after treatment. The ratio of amount of remaining active allergen after treatment with deactivant and tannic acid is also given.
- the deactivants as set out in the following table, were used against Der-p allergens according to the above procedure and the results are as given below. What was measured were the amount of allergens remaining after treatment with deactivant and the amount of allergens remaining after vacuuming with no deactivant treatment.
- compositions for use in an aerosol for deactivating Der-f and Der-p allergens.
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Abstract
Der-f and/or Der-p dust mite allergens are deactivated by an amount of L-ascorbic acid. Spray compositions comprise said deactivant in aqueous form or in aerosol form with propellant and optional solvent.
Description
- It has been known for a long time that house dust can trigger allergenic reactions in humans, such as asthma and rhinitis. It was reported, as early as 1928, that it was the dust mites in the dust that were the primary source of the allergenic response but it was only in the 1960's that researchers appreciated its significance.
- It is believed that the faeces of two particular house dust mite species, Dermatophagoides farinae (known as Der-f) and Dermatophagoides pteronyssinus (known as Der-p) trigger the immune responses of the body, thereby giving rise to well known allergenic symptoms.
- A review of this is given in Experimental and Applied Acarology, 10 (1991) p. 167-186 in an article entitled “House dust-mite allergen”: A review by L. G. Arlian.
- Both the Der-f and Der-p species are found throughout the world. In some areas, Der-f will be the sole Dermatophagoides species. In other areas Der-p will be the sole species. In still other areas, the two species are both present through, generally, one or the other will predominate.
- One way to overcome these allergenic response has been to vacuum surfaces, such as carpets, that contain the dust mites and their faeces thoroughly and often, but that is both time consuming (i.e. has to be regularly done if one wants to make an allergenic free environment) and is very dependant on the efficiency of vacuum cleaner and filter bag used e.g. micron filter bag or 2-layer vacuum bags.
- An alternative method of creating an allergen-free environment has been to denature the allergen, for example as described in U.S. Pat. No. 4,806,526. The only effective method however of which we are aware is to apply tannic acid to the allergen. However, tannic acid can cause staining, and this is a particularly acute problem for light coloured carpets (e.g. white and light beige carpets) and other textile surfaces as tannic acid leaves a deep brown stain.
- Therefore, we have been looking for allergenic denaturants which will not stain susceptible surfaces such as carpets and still deactivate the allergen.
- We have discovered a number of allergen deactivants which are effective against both the Der-f and the Der-p species. Quite surprisingly, we have discovered that some of these deactivants are specific to the type of dust mite allergen being treated. For example an effective Der-f allergen deactivants will not automatically work effectively as a Der-p allergen deactivant.
- According to the invention there is provided a method for deactivating allergens derived from the Der-f and/or Der-p dust mite species, which comprises contacting the allergen with a deactivating effective amount of one or more of deactivants (herein after defined as the deactivant).
- The deactivants effective against one or both of Der-f allergens and Der-p allergens are:
-
- i) cedarwood oil,
- ii) hexadecyltrimethylammonium chloride,
- iii) aluminium chlorohydrate,
- iv) 1-propoxy-propanol-2,
- v) polyquaternium-10
- vi) silica gel,
- vii) propylene glycol alginate,
- viii) ammonium sulphate,
- ix) hinokitiol,
- x) L-ascorbic acid,
- xi) “immobilised tannic acid”, (hereinafter defined)
- xii) chlorohexidine,
- xiii) maleic anhydride,
- xiv) hinoki oil,
- xv) a composite of AgCl and TiO2,
- xvi) diazolidinyl urea,
- xvii) 6-isopropyl-m-cresol,
- xviii) a compound of formula I
- xix) the compound of formula II
- xx) a polymeric dialdehyde containing two or more of a recurring unit of the formula III
where n=2 to 200, - xxi) urea,
- xxii) cyclodextrin,
- xxiii) hydrogenated hop oil,
- xxiv) polyvinylpyrrolidone,
- xxv) N-methylpyrrolidone,
- xxvi) the sodium salt of anthraquinone,
- xxvii) potassium thioglycolate, and
- xxviii) glutaraldehyde
Deactivants (i) through (xx) are effective against both Der-f and Der-p allergens. Deactivants (xxi) through (xxvi) are effective against Der-f allergens only. Deactivants (xxvii) and (xxviii) are effective against Der-p allergens only.
- A compound of formula I is commercially available as Aerosol OT.
- The compound of formula II is commercially available as parsley camphor.
- Hinoki oil is a mixture of thujan-3-one, 2-pinene, 3,5,7,3′,4′-pentahydroflavanone and 1,3,3-trimethyl-2-norcamphanone.
- Hydrogenated Hop Oil is the potassium salt of tetrahydroiso humulinic acid (also known as reduced isomerised hop extract).
-
- Chlorohexadine is 1,1′-hexamnethylenebis [5-(4-chlorophenyl)]-biguanide.
-
- Germall II is diazolidinylurea.
- Thymol is 6-isopropyl-m-cresol.
- Cedarwood oil contains α- and β-cedrene (ca 80%), cedrol (3-14%) and cedrenol. Other sesquiterpenes and some monoterpenes are also present.
- Polyquaternium-10 is a polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with a trimethyl ammonium substituted epoxide commercially available as Polymer JR-125.
- Silica gel is also known as colloidal silica or silicic acid and is commercially available as Kent.
- “Immobilised tannic acid” is tannic acid on polyvinyl pyrrolidone beads. Immobilised Tannic Acid was prepared as follows: 100 mg of tannic acid was dissolved in water; 50 mg of Polyclar 10 (ISP, Guildford Surrey) polyvinyl pyrrolidone beads were added and stirred for one hour; the beads were filtered off the solution and washed with a few mls of iced water until no colour was seen in the washings; they were then dried in the oven at 50° C.
- The composite of silver chloride and TiO2 is made up of 20% wt/wt AgCl on 80% TiO2 3-5 μm porous beads.
- In compositions containing the deactivant, the deactivant is present in an amount of from 0.01% to 7%, preferably from 0.01% to 3%.
- In methods for treating rugs and carpets to deactivate allergents, the amount of deactivant present is from about 16 gm to about 170 gm per 10 square meters, preferably about 32 gm per 10 square meters.
- Preferably the deactivant is selected from
-
- xiv) hinoki oil,
- xv) a composite of AgCl and TiO2,
- xvi) diazolidinyl urea
- xvii) 6-isopropyl-m-cresol,
- xii) chlorohexidine,
- xiii) maleic anhydride,
- xxvi) the sodium salt of anthraquinone and
- xviii) a compound of formula I or II, defined above, and
- xix) a compound of formula II, defined above.
- Further according to the invention there is provided an aerosol composition containing
-
- i) cedarwood oil,
- ii) hexadecyltrimethylammonium chloride,
- iii) aluminium chlorohydrate,
- iv) 1-propoxy-propanol-2,
- v) polyquaternium-10
- vi) silica gel,
- vii) propylene glycol alginate,
- viii) ammonium sulphate,
- ix) hinokitiol,
- x) L-ascorbic acid,
- xi) “immobilised tannic acid”, (hereinafter defined)
- xii) chlorohexidine,
- xiii) maleic anhydride,
- xiv) hinoki oil,
- xv) a composite of AgCl and TiO2.
- xvi) diazolidinyl urea,
- xvii) 6-isopropyl-m-cresol,
- xviii) a compound of formula I
- xix) the compound of formula II
- xx) a polymeric dialdehyde containing two or more of a recurring unit of the formula III
where n=2 to 200, - xxi) urea,
- xxii) cyclodextrin,
- xxiii) hydrogenated hop oil,
- xxiv) polyvinylpyrrolidone,
- xxv) N-methylpyrrolidone,
- xxvi) the sodium salt of anthraquinone,
- xxvii) potassium thioglycolate, and
- xxviii) glutaraldehyde
- b) a propellant, and
- c) optionally, a solvent.
- Preferably the amount of deactivant present in such a composition is from 0.01% to 7%, more preferably 0.01% to 3%,
- Preferably the amount of propellant present in such a composition is from 4% to 50%, more preferably from 4% to 30%,
- Preferably the amount of solvent present in such a composition is 0% to 99.95%, more preferably 0% to 90%, and most preferably from 20% to 90%.
- Preferably the deactivant in such aerosol composition is selected from
-
- hinoki oil,
- a composite of AgCl with TiO2,
- diazolidinyl urea,
- 6-isopropyl-m-cresol,
- chlorohexidine,
- maleic anhydride,
- the sodium salt of anthraquinone, and
- a compound of formula I or II: defined above.
- Preferably the propellant is selected from those commercially available, for example C1-4 alkanes, chlorofluorocarbons and compressed gases such as nitrogen, air and carbon dioxide.
- Preferably the solvent is selected from C1-6 alcohols (e.g. ethanol) or water.
- In addition, the compositions of this invention may also contain one or more of the following:
-
- a fragrance, preferably in an amount of 0% to 5%, more preferably 0% to 2%;
- an antimicrobial compound e.g. alkyldimethylbenzyl ammonium saccharinate, preferably in an amount of 0.01% to 1%;
- a surfactant, e.g. Dow Corning 193 Surfactant, preferably in an amount of 0.01% to 1%;
- a corrosion inhibitor, e.g. sodium nitrite, sodium benzoate, triethanolamine and ammonium hydroxide, preferably in an amount of 0.01% to 10%; and
- a miticide, such as benzyl benzoate, pyrethroid pemethrin, d-allethrin and optionally a synergist such as piperonyl butoxide, preferably in an amount of 0.1% to 10%.
- It has been found that deactivants of the invention have as effective allergen deactivating properties as tannic acid but without the drawback of staining.
- The invention will now be illustrated by the following Examples.
- The test procedure in Examples 1 to 55 is as follows and is known as the ELISA protocol.
- The ELISA protocol for Der-f and Der-p has been developed as follows as a measure of denaturing property for denaturants.
- ELISA Protocol 1
- 1. Dust is collected from Hoover™ vacuum cleaner bags and passed through a series of sieves down to 63 microns.
- 2. Clean petri dishes are labelled with the chemical to be tested (on the base). Three replicates are used for each treatment.
- 3. Filter paper is used to line each dish and 0.2 g of dust is added to each dish onto the filter paper. The lid (or base, as dishes are inverted) is replaced and the dish is shaken to disperse the dust evenly over the filter paper.
- 4. 2% aqueous solutions of deactivant were used except for the silver chloride composite where 0.05% was used instead. Immobilised tannic acid was used as a 1% dispersion. The hydrogenerated hop end was used at the 2% level (in the form of a 10% solution). Water-insoluble deactivants were emulsified with a sorbitone oleate surfactant (i.e. Tween). Hinokitol was used at 0.5% not 2%.
- 5. The dust is sprayed with the corresponding treatment, 2 sprays are required for sufficient coverage(1 spray=1.5 ml).
- 6. Leave uncovered at room temperature, in well aerated room, until filter paper is dry. This can take up to 4 hours.
- 7. Empty dust in epindorfs labelled according to treatment.
- 8. Add 1 ml of 5% Bovine Serum Albumen Phosphate Butter Saline—Tween BSA-PBS-T to each epindorf (5 times the weight of dust) (20 ml of BSA-PBS-T=1 g of BSA in 20 ml of PBS-T).
- 9. Leave overnight in a refrigerator.
- 10. Centrifuge for 5 minutes at 13,000 rpm.
- 11. Decant the supernatant into a new epindorf labelled according to treatment.
- 12. Centrifuge again for 5 minutes at 13,000 rpm.
- 13. Make up dilutions of 1:10 and 1:100 by adding 100 μl of neat solution to 900 μl of 1% BSA-PBS-T (1:10). This is repeated using 100 μl of 1:10 dilution and add to 900 μl of 1% BSA-PBS-T for 1:100 dilution.
- ELISA Protocol 2 for Der-f and Der-p: Indoor Biotechnologies
- 1. Prepare samples and dilutions as in protocol
- 2. Prepare 500 ml of 50 mM carbonate/bicarbonate buffer by dissolving 0.795 g Na2CO3 and 1.465 g NaHCO3 in 500 ml of distilled water. Check the pH is at 9.6. (This solution is kept in the refrigerator in a conical flask).
- 3. Monoclonal antibody (kept in the freezer) has to be added to the buffer using the following method, (1 μg per well; 11 ml is needed) applied to the ELISA plate
-
- 11 ml of carbonate/bicarbonate buffer is added to the dispensing tray.
- 11 μl of Der-f1 or Der-p1 monoclonal antibody
- (Stored in freezer, epindorf in use is in the refrigerator) is added to the buffer. To ensure that all the antibody is removed from the tip, wash out the pipette tip by sucking up and down I the buffer solution, gently stirring to mix thoroughly.
- 4. Pipette 100 μl of the antibody solution into each well of the microtiter plate, cover with a plate sealer and leave overnight at 4° C.
- 5. Empty the plate by quickly inverting it over the sink, then dry by banging on a stack of paper towels.
- 6. Add 200 μl of wash buffer to each well: PBS/0/05% tween (PBS-T).
- 7. Repeat stages 5 and 6 once more (making a total of 2 washes).
- 8. Make sure all the wells are dry, then add 100 μl of 1% BSA-PBS-T. Replace the plate sealer and incubate for 1 hour at room temperature*.
- 9. Repeat steps 5 to 7 (2 washes).
- 10. *During the hour incubation period, prepare the allergen standards at dilutions between 125 and 1 μg/ml Der f 1 or Der p1:
-
- Add 25 μl of allergen standard (kept in the refrigerator in polystyrene box) to 475 μl of 1% PBS-BSA-T and mix thoroughly—labelled ‘125’.
- 250 μl of 1% PBS-BSA-T is added to 7 further epindorfs which are labelled 62.5, 31.25, 15.63, 7.61, 3.9, 1.95 and 0.98.
- 250 μl is taken from the 1st epindorf (labelled 125) and transferred to the next (labelled 62.5). This is mixed thoroughly.
- Using a new pipette tip, 250 μl is removed from epindorf labelled 62.5 and transferred to 31.25, this procedure is continued down to the 0.98 concentration (125, 62.5, 31.25, 15.63, 7.61, 3.9, 1.95, 0.98)
- In total 475+(250×7)=2.3ml : 0.023 g of BSA added to 2.3 ml of PBS-T.
- 11. Add 100 μl aliquots of the allergen sample to the plate along with the standard allergen samples for the reference curve in duplicate. The standards usually go in the first two columns on the left hand side, with the least concentrated on top. Incubate for 1 hour.
- 12. Follow stages 5 to 6, completing a total of 5 washes.
- 13. Pour 11 ml of 1% BSA-PBS-T(0.11 g of BSA to 11 ml of PBS-T) to the dispensing tray. Add 11 μl of the biotinylated monoclonal antibody (refrigerator) and mix thoroughly.
- 14. Pipette 100 μl into each well and incubate for 1 hour at room temperature.
- 15. Empty plate and wash as described in stage 12. (5 washes).
- 16. Add 11 μl of Streptavidin (freezer) to 11 ml of 1% BSA-PBS-T. Pipette 100 μl into each well and incubate for 30 minutes. Reserve any remaining solution in a vial.
- 17. Empty plate and wash as described in stage 12 (5 washes).
- 18. Make a solution of OPD, by putting the two tablets (in silver and gold foil) into 20 ml of distilled water (in a glass vial). Shake quite vigorously in the dark until the tablets have dissolved (Wrap the vial up either in tin foil or paper towel).
- 19. Add a small amount to the remaining solution from stage 16. Wait for a colour change (positive reaction). Add 200 μl to each well and incubate for a minimum of 30 minutes in the dark.
- 20. Read the plate at 450 nm/405 nm if filter not available.
- The deactivants, as set out in the following table, were used against Der-f allergens according to the above procedure and the results are as given below. Tannic acid was used as a comparator. What was measured after treatment with deactivant and tannic acid was the amount of allergen remaining active after treatment. The ratio of amount of remaining active allergen after treatment with deactivant and tannic acid is also given.
TABLE Amount of Ratio of remaining Allergen active allergen Amount of Allergen remaining active after remaining active after after tannic acid Deactivant/Tannic Example Deactivant deactivant treatment treatment Acid Treatment Number 1 Urea 3750 1500 2.500 xxi 2 Polymeric dialdehyde 1325 550 2.409 xx 3 Cedarwood oil 1800 750 2.400 i 4 Cyclodextrin 3850 1700 2.265 xxii 5 hexadecyltrimethylammonium chloride 4075 1800 2.264 ii 6 Aluminium chlorohydrate 1675 750 2.233 iii 7 1-propoxy-propanol-2 3950 1800 2.194 iv 8 Silica Gel (Kent) 2037.5 933.5 2.183 vi 9 polyquaternium-10 (Polymer JR-125) 4335 2000 2.168 v 10 Hydrogenated Hop Oil 1100 550 2.000 xxiii 11 Propylene glycol alginate 3175 1700 1.868 vii 12 Poly vinyl pyrrolidone 2450 1425 1.719 xxiv 13 Ammonium sulphate 2750 1700 1.618 viii 14 Hinokitol (0.5%) 3065 2000 1.533 ix 15 N-methyl pyrrolidone 1600 1175 1.362 xxv 16 L-Ascorbic Acid 2000 1500 1.333 x 17 Immobilised Tannic Acid 1550 1175 1.319 xi 18 Aerosol OT 1525 1175 1.298 xviii 19 Chlorohexidine 1412.5 1425 0.991 xii 20 Parsley Camphor 1225 1387.5 0.883 xix 21 Maleic anhydride 1312.5 1500 0.875 xiii 22 Anthraquinone sodium salt 1530 2000 0.765 xxvi 23 Hinoki oil 1025 1387.5 0.739 xiv 24 Composite of AgCl and TiO2 1025 1425 0.719 xv 25 Germall II 950 1387.5 0.685 xvi 26 Thymol 725 1387.5 0.523 xvii - The deactivants, as set out in the following table, were used against Der-p allergens according to the above procedure and the results are as given below. What was measured were the amount of allergens remaining after treatment with deactivant and the amount of allergens remaining after vacuuming with no deactivant treatment.
TABLE Amount of active Allergen remaining after deactivant Example Deactivant treatment Deactivant Amount of active Allergen remaining after no deactivant treatment but only vaccuming 1 Glutaraldehyde 816 3375 xxviii 2 Polymeric dialdehyde 2792 3375 xx 3 Cedarwood oil 3375 6000 i 4 hexadecyltrimethylammonium 2863 4992 ii chloride 5 Aluminium chlorohydrate 978 4992 iii 6 1-propoxy-propanol-2 1233 4992 iv 7 Silica Gel (Kent) 1540 4992 vi 8 polyquaternium-10 5463 6250 v (Polymer JR-125) 9 Propylene glycol alginate 3781 6250 vii 10 Ammonium sulphate 2325 6250 viii 11 Potassium thioglycolate 3092 3375 xxvii Amount of Allergen remaining after no deactivant treatment 12 Hinokitol (0.5%) 2058 3375 ix 13 L-Ascorbic Acid 1438 5642 x 14 Immobilised Tannic Acid 1125 5642 xi 15 Aerosol OT 4494 5642 xviii 16 Chlorohexidine 2281 4450 xii 17 Parsley Camphor 2581 4450 xix 18 Maleic anhydride 783 4450 xiii 19 Hinoki oil 1644 3400 xiv 20 Composite of AgCl and TiO2 1632 3400 xv 21 Thymol 1500 3400 xvii - Further samples were tested as above and compared against tannic acid. The ratio of actives remaining after deactivant treatment and actives remaining after tannic acid treatment are given below:
Ratio of actives remaining after deactivant treatment over those remaining after tannic acid Example Deactivant treatment Number 48 Germall II 1.5 vi 49 N-methyl pyrrolidone 4.0 xv 50 Hinoki Oil 4.0 iv 51 Silver chloride/TiO2 3.5 v 52 Thymol 4.0 vii 53 Chlorohexidine 3.0 ii 54 Maleic 1.0 iii anhydride 55 Glutaraldehyde 1.5 xviii - The following formulations can be made up as carrier compositions for use in an aerosol for deactivating Der-f and Der-p allergens.
-
Raw Ingredient Description By Weight Item Classification % Anhydrous Ethanol (SD Solvent 79.646 Alcohol 40) Alkyl dimethyl benzyl Cationic Surfactant 0.106 ammonium saccharinate Corrosion Inhibitor (I) 0.192 Corrosion Inhibitor (II) 0.192 Corrosion Inhibitor (III) 0.096 Deionized Water Water/Solvent 15.768 Carbon Dioxide Propellant 4.000 TOTAL 100.000 -
Raw Ingredient Item Description by Weight Classification % Anhydrous Ethanol (SD Solvent *57.000 Alcohol 40) Fragrance#17 Fragrance 0.0500 Dow Corning 193 Surfactant 0.025 Surfactant Corrosion Inhibitor (I) 0.100 Corrosion Inhibitor (II) 0.100 Deionized Water Water/solvent *14.725 NP-40/Butane 40 Hydrocarbon 28.000 propellant TOTAL 100.000
*= May replace with 95% Ethanol (SD Alcohol 40) at 61.755% by weight and 9.970% by weight Deionized water
-
Raw Ingredient Item Description by Weight Classification % Anhydrous Ethanol (SD Solvent 79.646 Alcohol 40) Benzyl Benzoate —an Active/ester 4.600 acaricide Alkyl dimethyl benzyl Cationic Surfactant 0.106 ammonium saccharinate Corrosion Inhibitor (I) 0.192 Corrosion Inhibitor (II) 0.192 Corrosion Inhibitor (III) 0.096 Deionized Water Water/solvent 11.168 Carbon Dioxide Propellant 4.000 TOTAL 100.000 -
Raw Ingredient Item Description by Weight Classification % Anhydrous Ethanol (SD Solvent *57.000 Alcohol 40) Benzyl Benzoate Active/ester 4.600 Fragrance#17 Fragrance 0.0500 Dow Corning 193 Surfactant 0.025 Surfactant Corrosion Inhibitor (I) 0.100 Corrosion Inhibitor (II) 0.100 Deionized Water Water/solvent *10.125 NP-40/Butane 40 Hydrocarbon 28.000 propellant TOTAL 100.000
*= May replace 95% Ethanol (SD Alcohol 40) at 61.755% by weight and 5.370% by weight Deionized water.
Claims (14)
1. A method for deactivating a Der-f and/or a Der-p allergen comprising contacting the allergen with a deactivating effective amount of L-ascorbic acid.
2. A method according to claim 1 in which the allergen is a Der-f allergen.
3. A method according to claim 1 in which the allergen is a Der-p allergen.
4. A method for deactivating allergens deriving from Der-f and/or Der-p dust mites, said allergens being associated with faecal particles excreted by said mites on the surfaces of fabric materials selected from rugs, carpet and upholstered furniture, which method comprises applying to said fabric materials L-ascorbic acid.
5. A method according to claim 4 in which the allergens derive from Der-f dust mites.
6. A method according to claim 4 in which the allergens derive from Der-p dust mites.
7. A sprayable composition comprising L-ascorbic acid as a deactivant.
8. A composition according to claim 7 which is an aqueous composition.
9. A composition according to claim 7 which is an aerosol composition comprising said deactivant, a propellant and, optionally, a solvent.
10. A composition according to claim 9 in which the amount of deactivant present is from 0.01% to 7%, the amount of propellant present is from 0.05% to 3%, and the amount of solvent present is from 0% to 99.95%, all percentages being by weight.
11. A composition according to claim 10 in which the propellant is selected from the group consisting of C1-4 alkanes and carbon dioxide.
12. A composition according to claim 10 in which the solvent is selected from the group consisting of C1-6 alcohols, water and mixtures thereof.
13. A composition according to claim 12 in which the solvent is ethanol.
14. A composition according to claim 7 which additionally comprises one or more of a fragrance, a surfactant, an antimicrobial agent, a corrosion inhibitor, and a miticide.
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GB9720275A GB2329586A (en) | 1997-09-25 | 1997-09-25 | House dust mite allergen deactivation |
GB9720275.8 | 1997-09-25 | ||
GB9720298A GB2329587A (en) | 1997-09-25 | 1997-09-25 | House dust mite allergen deactivation |
US09/509,308 US6800247B1 (en) | 1997-09-25 | 1998-09-22 | Deactivants for dust mite allergens |
US10/911,895 US20050008579A1 (en) | 1997-09-25 | 2004-08-05 | Deactivants for dust mite allergens |
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