WO2005014770A1

WO2005014770A1 - Allergen reducing agent, composition containing same and method for reducing allergen

Info

Publication number: WO2005014770A1
Application number: PCT/JP2004/011288
Authority: WO
Inventors: Hiroki Onoe; Seiichi Tobe; Hazime Shigematsu; Hiroshi Akimoto; Toshiyuki Watanabe
Original assignee: Lion Corporation
Priority date: 2003-08-07
Filing date: 2004-07-30
Publication date: 2005-02-17
Also published as: JPWO2005014770A1

Abstract

Disclosed is an allergen reducing agent which is composed of water-insoluble particles mainly containing a synthetic inorganic substance and having an average particle diameter of 1-300 nm and has a hemoglobin aggregation rate of not less than 40%. Also disclosed are a composition containing such an allergen reducing agent and methods for reducing allergen using those.

Description

Description Allergen reducing agent, composition containing the same, and allergen reducing method

TECHNICAL FIELD The present invention relates to an agent having an allergen-reducing effect having excellent dispersion stability when compounding a liquid product, a composition containing the same, and a method for reducing allergens.

This application claims the priority of Japanese Patent Application No. 2003-289251 filed on Aug. 7, 2003, the contents of which are incorporated herein by reference. Background technology

In recent years, hay fever caused by cedar pollen and allergic symptoms caused by house dust caused by mites have become serious problems.

Various agents and compositions capable of adsorbing and detoxifying allergens have been proposed to address such problems (for example, Patent Documents 1 and 2 below).

Patent Document 1; JP-A-2000-16941

Patent Document 2; Japanese Patent Application Laid-Open No. 2002-167332

Patent Document 1 described above discloses a water-swellable clay mineral having an average particle diameter of 1 to 5000 nm, an absolute value of the zero-emission potential of 30 mV or more, and a purity of 90% or more as measured by a powder X-ray diffraction method. It is described that pollen can be rendered harmless with the combined hay fever preventive agent.

Patent Document 2 discloses that at least one selected from the group consisting of kaolin, talc, sericite, mica, silica, caic acid and / or a salt thereof, caic anhydride, titanium oxide, and activated carbon is used in an aqueous medium having a pH of 3 to 7. And an allergen-adsorbing sheet in which a nonwoven fabric is impregnated with the allergen-adsorbing composition. In order to commercialize agents and compositions having an allergen-reducing action, the effect of reducing the allergen must be stably exhibited, the discoloration of the material to be treated must not occur, and the liquid It is necessary to satisfy the conditions such as being free from aggregation or the like and having excellent dispersion stability even when blended in products.Therefore, it is necessary to develop a highly practical allergen reducing agent that satisfies these conditions. Had been.

The present invention has been made in view of such circumstances, and can stably obtain an effect of reducing allergens, rarely discolors an object to be processed such as a textile product, and has a stable dispersion when compounding a liquid product. An object of the present invention is to provide an allergen-reducing agent which has excellent properties and is suitable for being used by being mixed in a liquid, a composition containing the allergen-reducing agent, and a method for reducing allergen using the same. Disclosure of the invention

The present inventors have found that water-insoluble particles mainly composed of a synthetic inorganic substance having an average particle diameter of 1 to 300 nm and a hemoglobin aggregation rate of 40% or more have an allergen-reducing effect and are blended with a liquid product. It has been found that the dispersion stability at the time is excellent, and thus the utility is high, and the present invention has been completed. The allergen reducing agent of the present invention is characterized by comprising water-insoluble particles having a mean particle diameter of 1 to 300 nm mainly containing a synthetic inorganic substance, and having a hemoglobin aggregation rate of 40% or more.

The allergen reducing agent of the present invention may be used for articles in a living environment or for textile products.

The present invention also provides a method for reducing an allergen, which comprises contacting the allergen reducing agent of the present invention with an allergen.

The allergen-reducing agent of the present invention can reduce the allergen by bringing it into contact with the allergen, and exhibits its effects stably. The allergen reduction in the present invention includes removal of allergen, inactivation of Z or allergen, and adsorption of Z or allergen, and / or allergen. Means that

The allergen-reducing agent of the present invention hardly causes discoloration of the processed object even if it adheres to the processed object such as a textile product. Also, since it is insoluble in water, its effect is impaired even when dispersed in It is suitable for use in a liquid because it can be used stably. The present invention relates to a liquid containing an allergen-reducing agent (A) comprising water-insoluble particles having a mean particle size of 1 to 300 nm and containing a synthetic inorganic substance as a main component and having a hemoglobin aggregation rate of 40% or more. Provided is a liquid composition for reducing allergens.

The allergen-reducing liquid composition may further contain at least one component (B) selected from the group consisting of polyethylene glycol and alcohol ethoxylate.

The present invention comprises water-insoluble particles having an average particle diameter of 1 to 300 nm mainly composed of a synthetic inorganic substance, has a hemoglobin aggregation rate of 40% or more, and has a positively charged particle surface. Provided is a liquid composition for allergen reduction, comprising an allergen reducing agent (Α ′) and a cationic surfactant (C).

The allergen-reducing liquid composition of the present invention may be for articles in a living environment or for textiles.

The present invention also provides a method for reducing an allergen, which comprises bringing the liquid composition for reducing an allergen of the present invention into contact with an allergen.

According to the liquid composition for reducing allergens of the present invention, by contacting the liquid composition with an object to be treated, allergens adhering to the surface of the article to be treated can be effectively reduced. The present invention relates to an allergen reducing agent (A) comprising water-insoluble particles having a mean particle size of 1 to 300 nm and containing a synthetic inorganic substance as a main component and having a hemoglobin aggregation rate of 40% or more; And at least one component (B) selected from the group consisting of alcohol ethoxylates and alcohol ethoxylates.

The present invention also provides an allergen reduction method for bringing the liquid cleaning composition for textiles of the present invention into contact with an allergen.

ADVANTAGE OF THE INVENTION According to the liquid cleaning composition for textile products of this invention, it wash | cleans a to-be-processed object (fibrous product) using this, and at the same time as the to-be-processed object is wash | cleaned, Allergens can be effectively reduced. The present invention comprises water-insoluble particles having an average particle diameter of 1 to 300 nm mainly composed of a synthetic inorganic substance, has a hemoglobin aggregation rate of 40% or more, and has a positively charged particle surface. Provided is a liquid composition for treating fibers, which comprises an allergen reducing agent (Α ′) and a cationic surfactant (C).

The present invention also provides a method for reducing allergens, which comprises bringing the liquid composition for fiber treatment of the present invention into contact with an allergen.

According to the liquid composition for fiber treatment of the present invention, the object to be treated (fiber product) is treated with the liquid composition to modify the fiber surface of the object to be treated, thereby imparting a property improving effect. Allergens adhering to the object can be effectively reduced. BEST MODE FOR CARRYING OUT THE INVENTION

In the present invention, the target allergen is not particularly limited, and typical examples include pollen, mites, mold, house dust, pet waste, and the like.

'' Robin aggregation rate>

The value of the hemoglobin aggregation rate in the present invention is determined by the value obtained by the following test method.

That is, hemoglobin made from bovine blood is dissolved in purified water to a concentration of 0.4% by mass to prepare a “hemoglobin solution”.

Separately, prepare 1 M phosphate buffer with ρΗ6.0 (hereinafter referred to as “buffer Ρ”) and 1M Tris buffer with ΗΡ9.0 (hereinafter referred to as “buffer Τ”). .

The sample (liquid composition) to be evaluated is suspended in purified water so that the concentration of water-insoluble particles containing a synthetic inorganic substance as the main component is 1.0% by mass. Is prepared.

Keep each of these solutions at 25 ° C.

Next, using each solution prepared above and keeping the temperature in step 25, place the following sample solution in a test tube. Prepare AC and blanks 1 and 2.

Sample solution A: A solution obtained by mixing 1 mL of hemoglobin solution, 1 mL of buffer solution P, and 1 mL of purified water, and adding 1 mL of sample stock solution.

Sample solution B: A solution obtained by mixing 1 mL of hemoglobin solution, 1 mL of buffer T, and 1 mL of purified water, and adding 1 mL of sample stock solution.

Sample solution C: A solution obtained by mixing 1 mL of hemoglobin solution and 2 mL of purified water, then adding 1 mL of the sample stock solution and mixing.

Blank 1: Three types of blanks corresponding to the sample solutions A to C, respectively, in which 1 mL of purified water was used in the above sample solutions A to C instead of the sample stock solution.

Blank 2: Three types of blanks corresponding to the sample solutions A to C, in which 1 mL of purified water was used instead of the hemoglobin solution in the sample solutions A to C described above. After leaving the above sample solutions A to C and blanks 1 and 2 at room temperature (20 to 25 ° C) for 30 minutes, centrifuge at room temperature (about 1800 G, 5 minutes) to separate the supernatant. Then, measure the absorbance (hereinafter referred to as “OD value”) of the supernatant at a wavelength of 578 nm using a spectrophotometer.

Hemoglobin aggregation rate (%) is calculated by the following formula.

Hemoglobin aggregation rate (%) = (OD value of corresponding blank 1-OD value of sample solution A (or B or C)) Z (OD value of corresponding blank 1-OD value of corresponding blank 2) X 100

In this way, the hemoglobin agglutination rate (%) is determined for each of the sample solutions A to C which commonly use a certain sample (the liquid composition to be evaluated), and the highest value among the three values is determined for the sample. Hemoglobin aggregation rate.

The degree of allergen reduction by the allergen reducing agent or the composition containing the same can be evaluated, for example, using the allergen reduction rate determined by the ELISA (ELISA) method. The ELISA (ELISA) method is known, and is described, for example, in JP-A-2002-167332.

For example, to evaluate the rate of reduction of cedar pollen antigen (allergen), After adding cedar pollen to a solution of the enzyme-reducing agent or a composition containing the same and allowing the mixture to stand for a certain period of time, the amount of allergen reduction can be determined by measuring the amount of cedar pollen antigen using an ELISA method. A specific example will be described later. Reducer>

The allergen reducing agent of the present invention is composed of water-insoluble particles having an average particle diameter of 1 to 300 nm and composed mainly of a synthetic inorganic substance, and has a hemoglobin aggregation rate of 40% or more.

As used herein, the term “water-insoluble particles” refers to particles having a solubility of less than 0.1 g in 100 g of deionized water at 25 ° C. Further, non-swellable water which does not swell with water is preferable. When the hemoglobin aggregation rate is 40% or more, an effective allergen reduction effect can be obtained. The more preferable hemoglobin aggregation rate is 50% or more.

The allergen-reducing agent of the present invention preferably has an average particle size in the range of 1 nm to 300 nm, more preferably 1 nm to 70 nm, and still more preferably 1 nm to 70 nm. 30 nm.

Here, as the average particle diameter in this specification, a value measured by a dynamic light scattering method is adopted.

By setting the average particle size of the allergen-reducing agent within the above range, the surface area of the allergen-reducing agent is increased, and the amount of adsorption to the allergen is increased. The dispersion stability of the allergen-reducing agent in the inside becomes better, the transparency of the liquid product is obtained, and it is suitable for use in a liquid product.

Specific examples of the allergen reducing agent include colloidal silica, aluminum oxide sol, aluminum hydroxide sol, magnesium oxide sol, magnesium hydroxide sol, zinc oxide sol, zinc hydroxide sol, and colloidal gold particles.

Examples of particularly preferred allergen reducing agents include a colloidal sily force having an SiO content of 90% or more and an average particle diameter of 1 nm to 100 nm, and an oxidizing agent having an average particle diameter of 5 nm to 200 nm. Aluminum sol is mentioned.

Specific examples of aluminum oxide sol include aluminum sol-10 (Kawaken Fineke) Mical Co., Ltd.), Alumina Sol 100, Alumina Sol 200, (all manufactured by Nissan Chemical Co., Ltd.).

When colloidal silicic acid is used as an allergen reducing agent, cations such as sodium ion, lithium ion, lithium ion, ammonium ion, magnesium ion, and aluminum ion are blended in a dispersion of colloidal silicide to improve dispersion stability. Particularly preferred are those having improved properties and those having metal atoms such as aluminum on the surface or inside of the colloidal silica.

These forms of colloidal silica include, for example, Snowtex C, Snowtex Tex0, Snowtex OS, Snowtex S, Snowtex AK :, Snowtex CM, Snowtex XS, Snowtex QAS-40 (or more, Nissan Chemical Co., Ltd.), Silica Doll 20P, Silica Doll 20G-100 (all manufactured by Nippon Kagaku Kogyo Co., Ltd.), Ryuka Lloyd SI_550, Cataloid SN, Cataloid SA (all manufactured by Catalysis Chemical Industry Co., Ltd.), KLEBOSOL 50 R 50, KLEBOSOL 30 L 12, KLEBOSOL 30CAL 25, KLEBOSOL PL 40 R 25 (all manufactured by Clariant) and the like.

Among them, Snowtex C, Snowtex 0, Snowtex OS, Snowtex S, Snowtex AK, Snowtex CM, Snowtex XS, Snowtex Tx with average particle diameter of 1 nm to 70 nm — 40, Silica Doll 20 P, Cataloid SI— 550, Cataloid SN, Ryuka Lloyd SA, KL EB OSOL 50 R 50, KLEBOSOL 30 L 12, KLEBOSOL 30 CAL 25, KLEBOSOL PL40i 25, etc. It is particularly suitable as an allergen-reducing agent to be used in a liquid composition because it has high fluidity and good fluidity of the dispersion.

In particular, Snowtex with an average particle size of 1 nm to 30 nm (: Snowtex 0, Snowtex OS, Snowtex S, Snowtex AK, Snowtex XS, Silica Doll 20P, Cataloid SI-550, Cataloid SN, Cataloid SA, KLEBOSOL 30 L 12, KLEBOSOL 30 CAL 25, KLEBOSOL PL 40 R 25, etc. are extremely transparent and are most preferred. The allergen reducing agent of the present invention can effectively reduce the allergen by bringing it into contact with the allergen. When the allergen reducing agent of the product of the present invention is used, the pH is not particularly limited, but is preferably in the range of 2 to 11, more preferably in the range of 3 to 10 pH. Outside the above range, the dispersion stability may decrease.

Since the allergen-reducing agent of the present invention contains a synthetic inorganic substance as a main component, there is no variation in the allergen-reducing effect depending on the region or place where the product is produced as compared to the case where a natural product is used, and the uniform effect is stable. Can be obtained. Further, since it is an inorganic substance, problems of coloring of a solution and coloring of an object to be treated are less likely to occur as compared with an organic substance having a similar hemoglobin aggregation rate. Since a stable dispersion state can be obtained in the liquid, and since it is insoluble in water, it can be stably exhibited without impairing the allergen-reducing effect even when dispersed in the liquid. Therefore, it is suitable for use in a liquid.

The allergen reducing agent of the present invention can obtain an allergen reducing effect when used in various applications such as cosmetics, quasi-drugs, and pharmaceuticals in addition to miscellaneous goods such as detergents and fiber treatment agents.

The object to be treated to obtain an allergen-reducing effect by contacting the allergen-reducing agent of the present invention includes, in addition to textiles, body, and pets, housing, cars, textiles, space, furniture, toys, plush toys, etc. Articles can be applied.

The use form of the allergen reducing agent of the present invention is not particularly limited, but it is preferable to use the allergen reducing agent (particles) as a liquid composition in a state of being dispersed in a liquid. The liquid composition may be applied to the object by contacting the allergen to be reduced by the allergen-reducing agent. Spraying, application, volatilization, addition to the rinsing liquid, and addition of the allergen-reducing agent Various forms can be used, such as washing with an added detergent or wiping an object with a cleaning tool such as cloth, nonwoven fabric, sponge, or the like.

Specifically, the allergen-reducing agent is sprayed in an aerosol or dispenser container, and the allergen-reducing agent is attached to cleaning tools such as nonwoven fabric, paper, woven fabric, cloth products, sheets, cotton swabs, and mop. , Gel, detergent, rinse agent, textile treatment agent, softener, deodorant, antibacterial and antifungal agent, cleaning liquid, insecticide, mite repellent, miticide Agents, dehumidifiers, aerial sprays, fragrances and the like.

It can also be used by adhering to, or impregnating, a filter, mask, etc. of an air conditioner, air purifier, dehumidifier, dryer, ventilator, etc. As described above, the allergen-reducing agent is preferably brought into contact with the allergen in a state of being dispersed in the liquid. Since the allergen-reducing agent may dry on the surface of the filter or mask, etc., use liquids such as moisture and moisture in the air by using a substance that has water absorption and Z or moisture absorption together. Is preferably supplied to a filter, a mask or the like.

The allergen reducing composition of the present invention comprises a liquid containing the allergen reducing agent of the present invention.

The content of the allergen reducing agent in the liquid composition for allergen reduction varies depending on the use of the liquid composition.

(Concentration) is preferably 0.01 to 50% by mass, more preferably 0.01 to 40% by mass, particularly preferably 0.01 to 20% by mass.

If the content of the allergen-reducing agent is less than the above range, the desired allergen-reducing effect cannot be obtained sufficiently. If the content exceeds the above range, the dispersion stability of the allergen-reducing agent (particles) decreases. It is not preferable because it may cause

By having the allergen-reducing liquid composition contain at least one component (B) selected from the group consisting of polyethylene glycol and alcohol ethoxylate in addition to the allergen-reducing agent, an effect of improving dispersion stability can be obtained. In addition, deterioration of the allergen reduction effect at low temperatures (freezing and reconstitution) can be suppressed.

The polyethylene glycol preferably has a weight average molecular weight of 200 to 400, calculated from the hydroxyl group measured by the pyridine phthalic anhydride method according to JIS K155.6.4. A more preferred range of the mass average molecular weight is from 200 to 150.

The content of polyethylene glycol in the liquid composition for reducing allergens varies depending on the use of the composition. Degree) is preferably 0.01 to 50% by mass, more preferably 0.01 to 40% by mass, and particularly preferably 0.01 to 20% by mass. If the content is less than the above range, the effect of improving the dispersion stability cannot be exhibited, and if it exceeds the above range, the effect of reducing allergen may decrease, which is not preferable.

One kind of polyethylene glycol may be used, or two or more kinds may be used in combination. The alcohol ethoxylate is preferably an alcohol having an average carbon number of 10 to 20 and ethylene oxide (EO) added on average to 3 to 20 mol.

The content of the alcohol ethoxylate in the liquid composition for reducing allergens varies depending on the use of the composition. It is preferably 50% by mass, more preferably 0.01% to 40% by mass, and particularly preferably 0.01% to 20% by mass. If the content is less than the above range, the effect of improving the dispersion stability cannot be exhibited, and if it exceeds the above range, the allergen reduction effect may decrease, which is not preferable.

One type of alcohol ethoxylate may be used, or two or more types may be used in combination. Further, the above-mentioned polyethylene glycol and alcohol ethoxylate can be used in combination.

具体 Specific examples of the liquid composition for reducing allergens include aerosols, dispersers and sprays or sprays used in containers; cleaning tools such as nonwoven fabrics, sponges, paper, woven fabrics, fabric products, sheets, cotton swabs, or mop Impregnating liquid used by impregnating the liquid; a liquid detergent composition used in addition to a washing liquid and a rinsing liquid at the time of washing; a liquid composition for textile treatment; and the like.

The allergen-reducing liquid composition of the present invention may contain other components as appropriate according to the application as long as the effect of the allergen-reducing agent is not impaired. For example, liquid compositions such as detergents for textile products, textile treatment agents, softeners, cleaning solutions for homes, deodorants, antibacterial and antifungal agents, insecticides, mites repellents, miticides, dehumidifiers, and fragrances To the composition of the present invention with the allergen reducing agent of the present invention. The allergen-reducing liquid composition having such a composition can obtain an allergen-reducing effect together with the effects of the other components contained therein. <Liquid cleaning composition for textile products>

The liquid cleaning composition for textile products of the present invention contains the allergen reducing agent (A) of the present invention and at least one component (B) selected from the group consisting of polyethylene dalicol and alcohol ethoxylate.

The liquid cleaning composition for textile products in the present specification is a liquid cleaning composition used for cleaning various textiles such as clothes, sheets, curtains and cloths. The content of the allergen reducing agent (A) in the liquid cleaning composition for textile products varies depending on the use of the cleaning composition, but is expressed as a solid component (concentration) based on the total amount of the cleaning composition. It is preferably from 0.01 to 50% by mass, more preferably from 0.01 to 40% by mass, particularly preferably from 0.01 to 20% by mass.

If the content of the allergen-reducing agent (A) is less than the above range, the intended allergen-reducing effect cannot be sufficiently obtained. If the content exceeds the above range, the dispersion of the allergen-reducing agent (particles) will be stable. This is not preferred because the properties may be reduced.

By incorporating the component (B) in addition to the allergen-reducing agent (A) into the liquid cleaning composition for textiles, the effect of improving the dispersion stability can be obtained, and the effect of reducing the allergen at low temperatures (freezing and reconstitution) can be obtained. Deterioration can be suppressed.

The polyethylene glycol preferably has a mass average molecular weight of 200 to 400, calculated from the hydroxyl group measured by the pyridine anhydride method according to JIS K155.6.4. A more preferred range of the mass average molecular weight is from 200 to 150.

Although the content of polyethylene dalicol in the liquid cleaning composition for textiles varies depending on the use of the detergent, the solid content (concentration) is 0.01 to the total amount of the detergent composition. It is preferably from 50 to 50% by mass, more preferably from 0.01 to 40% by mass, particularly preferably from 0.01 to 20% by mass. If the content is less than the above range, the effect of improving the dispersion stability cannot be exhibited, and if the content exceeds the above range, the allergen reduction effect may decrease, which is not preferable.

One kind of polyethylene dalicol may be used, or two or more kinds may be used in combination. The alcohol ethoxylate is preferably an alcohol having an average carbon number of 10 to 20 to which an average of 3 to 20 mol of ethylene oxide (EO) is added. like this Alcohol ethoxylate is known as an E〇-added nonionic activator and also has a cleaning effect on textiles.

The content of alcohol ethoxylate in the liquid cleaning composition for textiles varies depending on the use of the cleaning agent, but is 0.001 to 100% in terms of solid content (concentration) based on the total amount of the cleaning composition. It is preferably 50% by mass, more preferably 0.01 to 40% by mass, and particularly preferably 0.01 to 20% by mass. If the content is less than the above range, the effect of improving the dispersion stability cannot be exhibited, and if it exceeds the above range, the effect of reducing allergens may decrease, which is not preferable.

One kind of alcohol ethoxylate may be used, or two or more kinds may be used in combination. The above-mentioned polyethylene daricol and alcohol ethoxylate can be used in combination.

In the liquid cleaning composition for textile products, in addition to the component (A) and the component (B), various components known as components of the liquid cleaning composition for textile products may be used without impairing the effects of the present invention. It can be blended in the range. Examples of such other components include the following components.

(1) Nonionic surfactants other than the alcohol ethoxylate contained in the component (B); linear alkylbenzene sulfonic acid (LAS), α-olefin sulfonic acid salt (AOS), polyoxyethylene alkyl ether sulfate ( LES), etc .; cationic surfactants, such as alkylamine hydrochloride and quaternary ammonium salt; amphoteric surfactants, such as amidopropyl laurate laurate; alkylamine oxide surfactants, etc. Various surfactants such as semi-polar surfactants;

(2) Film-forming inhibitors such as glycol solvents

(3) Low-temperature stabilizers such as sodium paratoluenesulfonate, sodium cumenesulfonate, and ethanol

(4) Recontamination inhibitor such as carboxymethylcellulose and polyethyleneimine derivatives

(5) Enzyme preparations such as protease, lipase, amylase, and cellulase

(6) Fluorescent agents such as distilbiphenyl-type fluorescent agents

(7) Antioxidants such as dibutylhydroxytoluene (8) Antibacterial agents such as Caisson CGZ I CP

(9) A fragrance such as a fragrance composition containing a fragrance component, a solvent, and a stabilizer described in JP-A-2001-146399

(10) pH adjusters such as sulfuric acid and sodium hydroxide

The pH of the liquid cleaning composition for textile products is not particularly limited, but is preferably in the range of 2 to 11. Outside the above range, the dispersion stability may decrease. When alcohol ethoxylate is not used as the component (B), it is necessary to add the surfactant (1) in order to obtain a cleaning effect.

The liquid composition for fiber treatment of the present invention contains an allergen-reducing agent (Α ′) whose particle surface is positively charged and a cationic surfactant (C).

The term "liquid composition for fiber treatment" as used in the present specification refers to a method of modifying the fiber surface of various textiles, such as clothes, sheets, cotton, cloth, etc., to impart flexibility, suppress shrinkage, wash, etc. It is a liquid composition capable of imparting a preferable property improving effect other than the above. As the allergen-reducing agent () ′), any of the above-described allergen-reducing agents of the present invention can be used without any particular limitation as long as the agent is confirmed to be positively charged by electrophoresis. . Specific examples include colloidal silica cationized with a polyvalent cation such as aluminum, and alumina sol.

Examples of the colloidal silica having a positively charged particle surface include Sunotex テック (manufactured by Nissan Chemical Co., Ltd.), Silica Doll 20 Ρ (manufactured by Nippon Chemical Industry Co., Ltd.), and KLEBOSOL 30CAL 25 (manufactured by Clarianto) .

Examples of the alumina sol having a positively charged particle surface include aluminum sol 10 (manufactured by Kawaken Fine Chemical Co., Ltd.), alumina sol 100, and alumina sol 200 (all manufactured by Nissan Chemical Industries, Ltd.).

The content of the allergen reducing agent (Α ') in the liquid composition for fiber treatment varies depending on the use of the liquid composition for fiber treatment, but the solid content (concentration) ) Is preferably 0.001 to 50% by mass, more preferably 0.01 to 40%, particularly preferably 0.01 to 20%. If the content of the allergen-reducing agent () ') is less than the above range, the desired allergen-reducing effect cannot be obtained sufficiently. If the content exceeds the above range, the allergen-reducing agent (particles) is dispersed. It is not preferable because stability may decrease.

By incorporating the cationic surfactant (C) in addition to the component (II ') into the liquid composition for fiber treatment, an effect of improving dispersion stability can be obtained. Cationic surfactants also have a fiber surface-modifying effect, such as a softening effect on fiber products.

Examples of the cationic surfactant include, but are not limited to, alkylamine hydrochloride and quaternary ammonium salt.

Particularly preferred cationic surfactants include di-long-chain alkyl (12 to 18 carbon atoms) di-short-chain alkyl (1 to 2 carbon atoms) type quaternary ammonium salt, and mono-long-chain alkyl (12 to 18 carbon atoms) Short-chain alkyl (1 to 2 carbon atoms) quaternary ammonium salt, tri-long-chain alkyl (12 to 18 carbon atoms) mono short-chain alkyl (1 to 2 carbon atoms) quaternary ammonium salt, and the like.

The content of the cationic surfactant (C) in the liquid composition for fiber treatment varies depending on the use of the liquid composition for fiber treatment, but is expressed as a solid content (concentration) based on the total amount of the composition. It is preferably from 0.001 to 50% by mass, more preferably from 0.01 to 40%, particularly preferably from 0.01 to 30%. If the content is outside the above range, the dispersion stability may decrease, which is not preferable.

One kind of the cationic surfactant (C) may be used alone, or two or more kinds may be used in combination. In addition to the component (Α ′) and the component (C), various components commonly used in fiber treatment agents can be added to the liquid composition for fiber treatment as long as the effects of the present invention are not impaired. Examples of the other components include the following components.

Dispersants such as nonionic activators

(2) Solvents such as ethyl alcohol, isopropyl alcohol, ethylene glycol and propylene glycol

(3) Texture improver

(4) Water repellents such as fluoropolymers

(5) ρΗ regulator

(6) Antibacterial agents such as sodium benzoate and thorium methyl balane (7) Antioxidant

(8) UV inhibitor

(9) Antistatic agent

(10) Fragrance

The pH of the liquid composition for treating fibers is not particularly limited, but is preferably in the range of 2 to 1: L1, and more preferably in the range of 3 to 8. Outside the above range, the dispersion stability may decrease.

The liquid composition for fiber treatment of the present invention can be applied to various fiber products such as clothes, curtains, cloths, stuffed animals and the like.

The form in which the liquid composition for fiber treatment is applied to the fiber product to be treated is not particularly limited as long as the liquid composition for fiber treatment is brought into contact with the allergen. For example, it may be added to a washing liquid or a rinsing liquid, or may be filled in various types of spray containers such as a trigger type and an aerosol type and sprayed. In particular, it is suitable as a general liquid composition for household fiber treatment. .

The liquid composition for fiber treatment of the present invention has a property improving effect on fiber products by using a cationic surfactant (C) and an allergen reducing agent (Α ′) having a positively charged particle surface. As well as good dispersion stability of the allergen-reducing agent (particles) in the liquid composition, the allergen adhering to textiles can be effectively reduced.

Further, the liquid composition for allergen reduction having the same composition as the liquid composition for fiber treatment of the present invention can be used for the above-mentioned applications other than fiber treatment.

<< Example >>

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

The reduction rate of Sgia allergen (unit:%) and the reduction rate of mite allergen in house dust (unit:%) in the following test examples and examples are the values obtained by the ELISA (ELISA) method. It is a value measured by the method. The hemoglobin aggregation rate (unit:%) is a value measured by the above-described method. Again The following methods were used to evaluate the effects of reducing the symptoms of lugi symptoms and the dispersion stability. <Measurement method of Sgia allergen reduction>

An antibody (anti-Cry j 1 monoclonal antibody 013 (manufacturer) prepared by dissolving 1.59 g of sodium carbonate and 2.93 g of sodium bicarbonate in distilled water and diluting 50-fold with a solution (carbonate buffer) adjusted to 100 OmL. Code HB L— Ab— 1— 013) Add 500 gZmL of tobacco and tok at a concentration of 500 gZmL (manufactured by Seikagaku Corporation) so that 10 OL (microliters) per 1 l of an imnoplate (manufactured by Nargenunc) is added. (Asahi Kasei Co., Ltd.) and left overnight at 4 ° C.

Discard the solution in the well and dissolve 0.267 g of monopotassium dihydrogen phosphate, 2.88 g of disodium monohydrogen phosphate and 8.0 g of sodium chloride in distilled water to make 100 OmL (PBS buffer) was added at 150 L / well, and the plate was shaken to wash. The solution was then discarded by inverting the plate, and the same washing and discarding was performed twice more.

A PBS acid buffer (BSA-PBS buffer) in which 1% by mass of bovine serum albumin (Sigma) was dissolved was added at 150 ^ L / well, and left at room temperature for about 1 hour. The solution in the well was discarded, and washing was performed by adding 150 L of PBS acid buffer per well. The solution was then discarded by inverting the plate, and the same washing and discarding was performed twice more.

Then, a separately prepared sample solution to be measured was added so as to have a concentration of 10 O / L per 1 μl, and left at room temperature for about 1 hour.

The solution in the well was discarded, and washing was performed by adding 15 O L of PBS acid buffer per well. The solution was then discarded by inverting the plate, and the same washing and discarding was performed twice more.

BSA—labeled antibody diluted 1000-fold with PBS buffer (horseradish peroxidase-labeled anti-Cry j 1 monoclonal antibody 053 (manufacturer code HBL-Ab-1-1053 P) stock concentration 250 gZmL, (Manufactured by Seikagaku Corporation) was added at a concentration of 100 iL / well, and reacted at room temperature for about 1 hour. After washing with Tween 20 (Tween 20, Merck) at a concentration of 0.05% by mass, a PBS buffer solution was added in an amount of 150 ^ L / well. Thereafter, the solution was discarded, the same washing and discarding were repeated, and the same solution was further washed with 300, and the solution was discarded.

Kuen acid (C ₆ H _S 〇 ₇ · H ₂ 〇) 7. 3 g and phosphate disodium _{_{(Na 2 H Ρ0 4 · 12Η}} 2 0) was dissolved 23. 9 g distilled water was prepared in 100 OML The solution (quenate / phosphate buffer A) was added at 300 L / well and left for about 1 minute, after which the solution was discarded.

Kuen acid (C ₆ H ₈ 〇 ₇ · H ₂ 〇) 10. 3 g, and phosphate disodium _{_{_{(Na 2 HP0 4 · 12H 2}}} 0) 35. were prepared and dissolved to 1000 mL with 8 g of distilled water soluble One tablet of OPD (o-phenylenediamine, manufactured by Cosmo Bio) is dissolved in 12 mL of the solution (quenate / phosphate buffer B), and then 12 L of 30% hydrogen peroxide solution is added, followed by coloring. Was prepared.

This coloring solution was added at 100 / zL per 1 μl, and left at room temperature for 15 minutes while shielding the light with aluminum foil (trade name, manufactured by Nippon Foil).

1 M sulfuric acid was added at 150 L / well, and the absorbance at 492 nm was measured using a microplate reader (Power Scan HT, manufactured by Dainippon Pharma Co., Ltd.).

(Preparation of sample solution 1)

A composition for evaluating cedar pollen collected from cedars grown and planted in Minamiashigara, Kanagawa Prefecture (Required so that the concentration of water-insoluble particles composed mainly of synthetic inorganic substances is 1.0% by mass. Cedar pollen concentration of 5 mgZmL, and left at room temperature for 1 hour, dilute 10-fold with distilled water, and further add 10 ml of PBS buffer. It was diluted twice.

The absorbance A was measured by the above procedure using the obtained solution as the sample solution to be measured. (Preparation of sample solution 2)

A first blank solution was prepared in the same manner as in Preparation 1 of the sample solution except that cedar pollen was not used. Using the first blank solution as the sample solution to be measured, the absorbance B1 was measured by the above procedure.

(Preparation of sample solution 3)

In preparation 1 of the sample solution, distilled water was used in place of the liquid composition to be evaluated. A second blank solution was prepared in the same manner except that was used. Using the second blank solution as the sample solution to be measured, the absorbance B2 was measured by the above procedure. (Calculation of allergen reduction rate)

Using the values of the absorbances A, B1, and B2 thus measured, the allergen reduction rate is calculated from the following equation.

Allergen reduction rate = {1-(A-B 1) / (B 2 -B 1)} X 100

The method for measuring the reduction rate of mite allergen in house dust in the present invention is different from the above-mentioned <method of measuring reduction rate of spear allergen> in the following points.

In the above-mentioned “Method of measuring the reduction rate of spiag allergen”, “anti-Cry j 1 monoclonal antibody 013, manufactured by Seikagaku Corporation” was used as the antibody, but “anti-Der f II monoclonal antibody (manufacturer code 15 E11), stock concentration: 400 g / mL, manufactured by Asahi Food and Healthcare Co., Ltd.

In the method for measuring the reduction rate of sphagial allergen in the above, "Rice-derived rust-derived peroxidase-labeled anti-Cry j 1 monoclonal antibody 053, manufactured by Seikagaku Corporation" was used as the labeled antibody, but instead "Rice-derived rust-derived peroxidase" was used. A labeled anti-Der f II monoclonal antibody (car code 13A4PO), stock concentration 200 Mg / mL, manufactured by Asahi Food and Health Care Co., Ltd. "was used.

In the above-mentioned “Method for measuring the rate of reduction of cedar allergens”, in “Preparation of sample solution 1”, “cedar pollen collected from a cedar planted and grown in Minamiashigara, Kanagawa” becomes “cedar pollen concentration of 5 mgZmL”. However, instead of this, "house dust collected using a home vacuum cleaner from a power unit used for 15 years at home" was changed to "house dust concentration of 2 OmgZmL". Was added.

Except for the above, the mite allergen reduction rate in house dust was measured in the same manner as in> Measurement method of mast allergen reduction rate.

After preparing the liquid composition to be evaluated, observe the appearance change after storage at 20 ° C for 10 days. The results were visually evaluated, and the results were evaluated as 〇 for no change, △ for turbidity but no sedimentation 生じ, and △ for aggregated sediment.

^: Evaluation of one symptom reduction effect>

100 Omg of cedar pollen collected from cedar inhabiting Minamiashigara City, Kanagawa Prefecture, was uniformly sprinkled on one side of a 30 cm x 30 cm cloth.

After applying the allergen-reducing liquid composition to be evaluated to this cloth, the hay fever is reduced in a clean room (clean room started by Tokyo Hitachi Refrigerant Co., Ltd .: positive pressure and air conditioning controlled by HEPA File Yuichi). 10 adult males who had the garments spent 6 hours beside the cloth that had undergone the above treatment. Then, it was determined whether allergic symptoms such as itchy eyes, sneezing, and 目の were reduced as compared to the case where pollen was merely adhered (no application of the liquid composition for reducing allergens). Was. 8 or more people reduced, 4 to 7 reduced, and 3 or less reduced X.

(Test example:! ~ 6)

With respect to water-insoluble particles mainly composed of various synthetic inorganic substances, the hemoglobin aggregation rate, sgia allergen reduction rate, mite allergen reduction rate, and dispersion stability were evaluated by the above method. The results are shown in Table 1 below.

The liquid compositions to be evaluated include the following particle-containing liquids a to f containing water-insoluble particles containing a synthetic inorganic substance as a main component at a predetermined concentration (pure content). The components were diluted with purified water so that the concentration of water-insoluble particles as components was 1.0% by mass.

Particle-containing liquid a: Snowtex XS, average particle diameter 4-6 nm, manufactured by Nissan Chemical Industries, Ltd. (pure content: 20% by mass)

Particle-containing liquid b: Snowtex OS, average particle size 8 to 1 nm, manufactured by Nissan Chemical Industries, Ltd. (pure content: 20% by mass)

Particle-containing liquid c: Snowtex AK, average particle diameter 10 to 2 O nm, manufactured by Nissan Chemical Industries, Ltd. (pure content 19% by mass) Particle-containing liquid d: Quartrone PL—20, average particle diameter of 21 nm, manufactured by Fuso Chemical Co., Ltd. (pure content: 20% by mass)

Particle-containing liquid e: Snowtex C, average particle diameter 10 to 20 nm, manufactured by Nissan Chemical Industries, Ltd. (purity: 20% by mass)

Particle-containing liquid f: silica doll 20 G—100, average particle diameter 11 1 nm, manufactured by Nissan Chemical Industries, Ltd. (pure content 20% by mass)

Particle-containing liquid g: Fine Seal A, average particle size 250 nm, manufactured by Tokuyama Corporation (purity 95% by mass)

As shown in the results of Table 1, when the hemoglobin aggregation rate was 40% or more, the allergen reduction rate was high, and the effect of effectively reducing allergen was obtained. In addition, good dispersion stability was obtained when the average particle diameter was in the range of 1 to 300 nm or less.

(Examples 1 to 3)

In addition to using the particle-containing liquids a and c and mixing the materials with the composition shown in Table 2 below, the liquid cleaning composition for textile products is used in Examples 1 and 2, and the liquid composition for reducing allergens is used in Example 3. Was prepared respectively. The compounding amounts of the particle-containing liquids a and c were such that the concentration of the water-insoluble particles containing the synthetic inorganic substance as a main component contained in each of the compounds had the composition shown in the table.

The compositions obtained in Examples 1 to 3 were all colorless and transparent.

For each of the obtained compositions, the allergic symptoms reducing effect and The dispersion stability was evaluated. In Examples 1 and 2, 20 mL of the obtained liquid cleaning composition for textiles was added to 30 L of the washing liquid to wash the cloth to which pollen had adhered, and the allergic solution was washed using the washed cloth. The symptom-reducing effect was evaluated. The laundry did not cause any discoloration of the fabric. In Example 3, 0.5 ml of the obtained liquid composition for reducing allergen was sprayed uniformly on the cloth surface to which pollen had adhered, and the effect of allergic symptom reduction was evaluated using the cloth after the spray treatment. This spraying did not cause discoloration of the fabric. The evaluation results are shown in Table 2 below.

In addition, when the component B was removed from the compositions of Examples 1 to 3, the allergen reduction effect deteriorated after freezing and reconstitution (frozen at −20 ° C. and then thawed at 20 ° C.) However, no deterioration occurred in the compositions of Examples 1 to 3. Table 2

(Blending unit: mass%, total amount 100 mass%)

(Example 4)

Using the above-mentioned particle-containing liquid c and the fiber treatment liquid, A body composition was prepared. The amount of the particle-containing liquid c was adjusted such that the concentration of the water-insoluble particles containing the synthetic inorganic substance as a main component contained therein was the composition shown in the table.

In addition, it was confirmed by electrophoresis that the water-insoluble particles mainly composed of synthetic inorganic substances in the particle-containing liquid C were positively charged.

The fiber treatment liquid composition obtained in Example 4 was colorless and transparent.

With respect to the obtained liquid composition for treating fibers, the allergen symptom reducing effect and dispersion stability were evaluated by the methods described above. The results are shown in Table 3 below.

In the evaluation of the allergic symptom-reducing effect, the cloth to which cedar pollen was attached was finished by adding 20 mL of the fiber treatment liquid composition to 30 L of the washing liquid, and then treating the cloth. It evaluated by the said evaluation method. After washing, the fabric did not discolor. Table 3

(Blending unit: mass%, total amount 100 mass%)

Industrial potential

ADVANTAGE OF THE INVENTION According to this invention, the effect which reduces an allergen can be obtained stably, the discoloration of the to-be-processed object, such as a textile product, is small, and the dispersion stability at the time of liquid product combination is excellent, An allergen-reducing agent suitable for blending and using, a composition containing the allergen-reducing agent, and an allergen-reducing method using these are obtained.

Claims

The scope of the claims

1. An allergen reducing agent consisting of water-insoluble particles having an average particle diameter of 1 to 300 nm and containing a synthetic inorganic substance as a main component and having a hemoglobin aggregation rate of 40% or more.

2. The allergen reducing agent according to claim 1, which is used for articles in a living environment.

3. The allergen reducing agent according to claim 1, which is used for textile products.

4. A method for reducing an allergen, which comprises contacting the allergen reducing agent according to claim 1 with an allergen.

5. An allergen consisting of a liquid containing an allergen-reducing agent (A), which is composed of water-insoluble particles having an average particle diameter of 1 to 300 nm and containing a synthetic inorganic substance as a main component and having a hemoglobin aggregation rate of 40% or more. Liquid composition for reduction.

6. The allergen-reducing liquid composition according to claim 5, further comprising at least one component (B) selected from the group consisting of polyethylene glycol and alcohol ethoxylate.

7. Allergens composed of water-insoluble particles with an average particle diameter of 1 to 300 nm mainly composed of synthetic inorganic substances, with a hemoglobin aggregation rate of 40% or more, and a positively charged particle surface A liquid composition for reducing allergens, comprising an agent (Α ') and a cationic surfactant (C).

8. The allergen-reducing liquid composition according to claims 5 to 7, which is used for articles in a living environment.

9. The allergen-reducing liquid composition according to any one of claims 5 to 7, which is used for textile products.

10. A method for reducing an allergen, which comprises bringing the liquid composition for reducing an allergen according to any one of claims 5 to 7 into contact with an allergen.

11. Allergen-reducing agent (A) consisting of water-insoluble particles having an average particle diameter of 1 to 300 nm mainly composed of synthetic inorganic substance and having a hemoglobin aggregation rate of 40% or more, polyethylene glycol and Selected from the group consisting of alcohol ethoxylates Liquid cleaning composition for textiles, comprising at least one component (B).

12. A method for reducing an allergen, which comprises bringing the liquid cleaning composition for textiles according to claim 11 into contact with an allergen.

13. Allergen reducing agent consisting of water-insoluble particles with an average particle diameter of 1 to 300 nm mainly composed of synthetic inorganic substances, having a hemoglobin aggregation rate of 40% or more, and having a positively charged particle surface ( A liquid composition for treating fibers, comprising Α ') and a cationic surfactant (C).

14. A method for reducing an allergen, which comprises bringing the liquid composition for fiber treatment according to claim 13 into contact with an allergen.