GB2329587A - House dust mite allergen deactivation - Google Patents

House dust mite allergen deactivation Download PDF

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Publication number
GB2329587A
GB2329587A GB9720298A GB9720298A GB2329587A GB 2329587 A GB2329587 A GB 2329587A GB 9720298 A GB9720298 A GB 9720298A GB 9720298 A GB9720298 A GB 9720298A GB 2329587 A GB2329587 A GB 2329587A
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United Kingdom
Prior art keywords
deactivant
formula
composition
allergen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9720298A
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GB9720298D0 (en
Inventor
Malcolm Tom Mckechnie
Gay Joyce Cornelius
Ian Andrew Thompson
Janette Kumyoung Suh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Priority to GB9720298A priority Critical patent/GB2329587A/en
Publication of GB9720298D0 publication Critical patent/GB9720298D0/en
Priority to GB9820220A priority patent/GB2329588B/en
Priority to ES98944081T priority patent/ES2197503T3/en
Priority to EP04020020A priority patent/EP1484089B1/en
Priority to DE69830256T priority patent/DE69830256T2/en
Priority to ES04020020T priority patent/ES2323460T3/en
Priority to AU91752/98A priority patent/AU9175298A/en
Priority to DE69840760T priority patent/DE69840760D1/en
Priority to US09/509,308 priority patent/US6800247B1/en
Priority to EP98944081A priority patent/EP1017428B1/en
Priority to ES02003296T priority patent/ES2239181T3/en
Priority to PCT/GB1998/002863 priority patent/WO1999015208A2/en
Priority to CA2695678A priority patent/CA2695678C/en
Priority to EP04018315A priority patent/EP1498156A3/en
Priority to ES02003297T priority patent/ES2239694T3/en
Priority to EP02003296A priority patent/EP1219323B1/en
Priority to DE69814427T priority patent/DE69814427T2/en
Priority to EP02003297A priority patent/EP1224955B1/en
Priority to CA2304639A priority patent/CA2304639C/en
Priority to DE69829698T priority patent/DE69829698T2/en
Priority to ARP980104774A priority patent/AR017145A1/en
Publication of GB2329587A publication Critical patent/GB2329587A/en
Priority to AU2003200400A priority patent/AU2003200400B2/en
Priority to US10/911,895 priority patent/US20050008579A1/en
Priority to US10/912,000 priority patent/US7537729B2/en
Priority to AU2006252279A priority patent/AU2006252279B2/en
Priority to AU2010200851A priority patent/AU2010200851B2/en
Withdrawn legal-status Critical Current

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Abstract

A Der-p allergen is deactivated by contacting it with a deactivating effective amount of one or more of i) cedarwood oil, ii) hexadecyltrimethylammonium chloride iii) aluminium chlorohydrate, iv) 1-propoxy-propanol-2, v) polyquaternium-10 vi) silica gel, vii) potassium thioglycolate viii) propylene glycol alginate, ix) ammonium sulphate, x) hinokitiol, xi) glutaraldehyde xii) L-ascorbic acid, xiii) "immobilised tannic acid", xiv) chlorohexidine, xv) maleic anhydride, xvi) hinoki oil, xvii) a composite of silver chloride and TiO2 xviii) diazolidinyl urea, xix) 6-isopropyl-m-cresol xx) a compound of formula I xxi) a compound of formula II

Description

Improvements in or relating to organic compositions It has been known for a long time that house dust can trigger allergenic reactions in humans, such as asthma and rhinitis. It was reported, as early as 1928, that it was the dust mites in the dust that were the primary source of the allergenic response but it was only in the 60's that researchers appreciated its significance.
It is believed that the faeces of the house dust mite, Dermatophagoides farinae (known as Der-f) and Dermatophagoides pteronyssinus (known as Der-p) trigger the immune responses of the body, thereby giving rise to well known allergenic symptoms.
A review of this is given in Experimental and Applied Acarology, 10 (1991) p. 167-186 in an article entitled "House dust-mite allergen" : A review by L. G.
Arlian.
One way to overcome these allergenic response has been to vacuum surfaces, such as carpets, that contain the dust mites and their faeces thoroughly and often, but that is both time consuming (i.e. has to be regularly done if one wants to make an allergenic free environment) and is very dependant on the efficiency of vacuum cleaner and filter bag used e.g. micron filter bag or 2 layer vacuum bags.
An alternative method of creating an allergen-free environment has been to denature the allergen, for example as described in US Patent No. 4,806,526. The only effective method however of which we are aware is to apply tannic acid to the allergen. However, tannic acid can cause staining, and this is a particularly acute problem for light coloured carpets (e.g. white and light beige carpets) and other textile surfaces as tannic acid leaves a deep brown stain.
Therefore, we have been looking for allergenic denaturants which will not stain susceptible surfaces such as carpets and still deactivate the allergen.
We have surprisingly found that deactivants are specific to the type of dust mite allergen being treated. For example an effective Der-f allergen deactivant will not automatically work effectively as a Der-p allergen deactivant.
We have looked into Der-p allergen deactivants and have found only a select number of deactivants destroy the Der-p allergen, whilst at the same time not leaving a stain.
According to the invention there is provided a method for deactivating a Der-p allergen comprising contacting the allergen with a deactivating effective amount of one or more of deactivants (herein after defined as the deactivant) selected from i) cedarwood oil, ii) hexadecyltrimethylammonium chloride iii) aluminium chlorohydrate, iv) 1-propoxy-propanol-2, v) polyquaternium-l0 vi) silica gel vii) potassium thioglycolate viii) propylene glycol alginate, ix) ammonium sulphate, x) hinokitiol, xi) glutaraldehyde, xii) L-ascorbic acid, xiii) "immobilised tannic acid", (hereinafter defined) xiv) chlorohexidine, xv) maleic anhydride, xvi) hinoki oil, xvii) a composite of AgCl and TiO2 xviii) diazolidinyl urea, xix) 6-isopropyl-m-cresol, xx) a compound of formula I,
o IIoctyl o+e 0 (I) Na 30S xxi) a compound of formula II
xxii) a polymeric compound containing two or more of a recurring unit of the formula III
where n = 2 to 200.
In this Specification, the definition of the following compounds or compositions is given below: A compound of formula I is commercially available as Aerosol OT.
A compound of formula II is commercially available as parsley camphor.
Hinoki oil is a mixture of Thujan-3-one, 2-pinene, 3,5,7,3',4' pentahydroflavanone and 1,3,3,trimethyl-2-norcamphanone.
Cedarwood oil, contains a- and p- cedrene (ca 80%), cedrol (3-14%) and cedrenol. Other sesquiterpenes and some monoterpenes are also present.
Polyquaternium-10 is a polymeric quaternary ammonium salt of hydroxy ethyl cellulose reacted with a trimethyl ammonium substituted epoxide commercially available as Polymer JR-125.
Silica gel is also known as colloidal silica or silicic acid and is commercially available as Kent.
Hinokitiol is also known as ss-thujaplicin.
"Immobilised tannic acid" is tannic acid on polyvinyl pyrrolidone beads. "Immobilised Tannic Acid" is prepared as follows: 100 mg of tannic acid dissolved in water, 50 mg of Polyclar 10 (ISP, Guildford Sumg) polyvinyl pyrrolidone beads were added and stirred for one hour. The beads were filtered off the solution and washed with a few mls of iced water until no colour was seen in the washings. They were then dried in the oven at 50 c.
The composite of silver chloride and TiO2 is made up of 20% wt/wt AgCl on 80% TiO2 3-5 um porous beads.
The amount of deactivant present is from 0.01 - 7%, preferably 0.01 to 3%.
Preferably the amount of deactivant present in such a method is from 0.5 oz to 5 oz per 10 yds2 , more preferably 1 oz per 11 yds2 of area treated.
Preferably the deactivant is selected from hinoki oil, a composite of AgCl and TiO2, diazolidinyl urea 6-isopropyl-m-cresol, N-methyl pyrrolidine potassium thioglycolate chlorohexidine maleic anhydride and glutaraldehyde hinokitiol silica gel cedarwood oil l-propoxy-propanol-2 aluminium chlorohydrate immobilised tannic acid, and L-ascorbic acid Most preferably the deactivant is selected from maleic anhydride, glutaraldehyde and diazolidinyl urea.
Further according to the invention there is provided an aerosol composition containing a) a deactivant (hereinafter the Deactivant) selected from i) cedarwood oil, ii) hexadecyltrimethylammonium chloride iii) aluminium chlorohydrate, iv) 1-propoxy-propanol-2, v) polyquaternium-lO, vi) silica gel, vii) potassium thioglycolate, viii) propylene glycol alginate, ix) ammonium sulphate, x) hinokitiol, xi) glutaraldehyde xii) L-ascorbic acid, xiii) "immobilised tannic acid", (hereinafter defined) xiv) chlorohexidine, xv) maleic anhydride, xvi) hinoki oil, xvii) a composite of silver chloride and TiO2 xviii) diazolidinyl urea, xix) 6-isopropyl-m-cresol, xx) a compound of formula I, II or III defined above; b) a propellant and c) optionally a solvent.
Preferably the amount of deactivant present in such a composition is from 0.01 - 7%, preferably 0.01 to 3%, Preferably the amount of propellant present in such a composition is 4-50%, more preferably 4 to 30%, Preferably the amount of solvent present in such a composition is 0 to 99.95, more preferably 0 to 90%, most preferably 20 to 90%.
Preferably the deactivant is selected from hinoki oil, a composite of AgCl with TiO2, diazolidinyl urea, 6-isopropyl-m-cresol, N-methyl pyrrolidone maleic anhydride, potassium thloglycolate chlorohexidine, glutaraldehyde. hinokitiol silica gel cedarwood oil 1-propoxy-propanol-2 aluminium chlorohydrate immobilised tannic acid, and L-ascorbic acid Preferably the propellant is selected from those commercially available, for example C14alkanes and hydrochlorofluorocabrons and compressed gases such as nitrogen air and carbon dioxide.
Preferably the solvent is selected from C16 alcohols (e.g. ethanol) or water.
In addition the composition may also contain one or more of the following a fragrance, (preferably in an amount of 0 to 5%), more preferably 0 to 2%. an antimicrobial compound e.g. alkyl dimethyl benzyl ammonium saccharinate (preferably in an amount of 0.01 to 1%) a surfactant (e.g. Dow Corning 193 Surfactant (preferably in an amount of 0.01 to 1%) a corrosion inhibitor (e.g. sodium nitrite, sodium benzoate, triethanolamine or ammonium hydroxide (preferably in an amount of 0.01 to 10%), and/or a miticide (such as benzyl benzoate, pyrethroid pemethrin, d-allethrin and optionally a synergist such as pipernoyl butoxide (preferably in an amount of 0.1 to 10%).
It has been found that deactivants of the invention have as effective allergen deactivating properties as tannic acid but without the drawback of staining.
The invention will now be illustrated by the following Examples.
The test procedure in Examples 1 to 17 is as follows and is known as the ELISA protocol.
The ELISA protocol for Der-P has been developed as follows as a measure of denaturing property for denaturants.
ELISA Protocol 1 1. Dust is collected from Hoover (a trademark) bags and passed through a series of sieves down to 63 microns.
2. Clean petri dishes are labelled with the chemical to be tested (on the base), three replicates are used for each treatment.
3. Filter paper is used to line each dish and 0.2g of dust is added to each dish onto the filter paper. The lid (or base, as dishes are inverted) is replaced and the dish is shaken to disperse of dust evenly over the filter paper.
4. 2% aqueous solutions of deactivant was used except for i) the silver chloride composite is used at 0.05%; ii) immobilised tannic acid is used as a 1% dispersion; iii) hinokitol is used at 0.5%.
Water insoluble deactivants are emulsified with surfactant (a sorbitol oleate surfactant (i.e. Tween)).
5. The dust is sprayed with the corresponding treatment, 2 sprays are required for sufficient coverage(1 spray = 1.5ml).
6. Leave uncovered at room temperature, in well aerated room, until filter paper is dry. This can take up to 4 hours.
7. Empty dust in epindorfs labelled according to treatment.
8. Add 1 ml of 5% Bovine Serum Albumen Phosphate Butter Saline - Tween BSA-PBS-T to each epindorf (5 times the weight of dust) (20ml of BSA-PBS-T =lg of BSA in 20ml of PBS-T).
9. Leave overnight in the fridge.
10. Centrifuge for 5 minutes at 13,000 rpm.
11. Decant the supernatant into a new epindorf labelled according to treatment.
12. Centrifuge again for 5 minutes at 13,000 rpm.
13. Make up dilution's of 1:10 and 1:100 by adding 100ul of neat solution to 900ul of 1% BSA-PBS-T (1:10).
This is repeated using 100ul of 1:10 dilution and add to 900ul of 1% BSA-PBS-T for 1:100 dilution.
ELISA Protocol 2 for Der p 1: Indoor Biotechnologies 1. Prepare samples and dilutions as in protocol 1.
2. Prepare 500 ml of 50 mM carbonate/bicarbonate buffer by dissolving 0.795g Na2CO3 and 1.465g NaHCO3 in 500ml of distilled water. Check the pH is at 9.6.
(This solution is kept in the fridge in a conical flask).
3. Monoclonal antibody, this is kept in the freezer.
(lug per well ; llml is needed) has to be added to the buffer using the following method this is applied to the ELISA plate: - ilmi of carbonate/bicarbonate buffer is added to the dispensing tray.
- lip1 of Der P 1 monoclonal antibody (Stored in freezer, epindorf in use is in the fridge) is added to the buffer. To ensure that all the antibody is removed from the tip, wash out the pipette tip by sucking up and down I the buffer solution, gently stirring to mix thoroughly.
4. Pipette 100p1 of the antibody solution into each well of the microtiter plate, cover with a plate sealer and leave overnight at 4 0C.
5. Empty the plate by quickly inverting it over the sink, then dry by banging on a stack of paper towels.
6. Add 200pl of wash buffer to each well: PBS/0/05% tween (PBS-T).
7. Repeat stages 5 and 6 once more (making a total of 2 washes).
8. Make sure all the wells are dry, then add lOOp1 of 1% BSA-PBS-T. Replace the plate sealer and incubate for 1 hour at room temperature*.
9. Repeat steps 5 to 7 (2 washes). lO.*During the hour incubation period, prepare the allergen standards at dilutions between 125 and 1 ng/ml Der f 1: - Add 25p1 of allergen standard (kept in the fridge in polystyrene box) to 475p1 of 1% PBS-BSA-T and mix thoroughly - labelled '125'.
- 250p1 of 1% PBS-BSA-T is added 7 further epindorfs which are labelled 62.5, 31.25, 15.63, 7.61, 3.9, 1.95 and 0.98.
- 250p1 is taken from the 1st epindorf (labelled 125) and transferred to the next (labelled 62.5).
This is mixed thoroughly.
- Using a new pipette tip, 250pl is removed from epindorf labelled 62.5 and transferred to 31.25, this procedure is continued down to the 0.98 concentration (125, 62.5, 31.25, 15.63, 7.61, 3.9, 1.95, 0.98) - In total 475+(250x7)=2.3ml : 0.023g of BSA added to 2.3ml of PBS-T.
11. Add 100p1 aliquots of the allergen sample to the plate along with the standard allergen samples for the reference curve in duplicate. The standards usually go in the first two columns on the left hand side, with the least concentrated on top.
Incubate for 1 hour.
12. Follow stages 5 to 6, completing a total of 5 washes.
13. Pore limi of 1% BSA-PBS-T(O.llg of BSA to llml of PBS-T) to the dispensing tray. Add ilpi of the biotinylated monoclonal antibody (fridge) and mix thoroughly.
14. Pipette 100pl into each well and incubate for 1 hour at room temperature.
15. Empty plate and wash as described in stage 12. (5 washes).
16. Add ilul of Streptavidin (freezer) to limi of 1%BSA-PBS-T. Pipette 100pl into each well and incubate for 30 minutes. Reserve any remaining solution in a vial.
17. Empty plate and wash as described in stage 12 (5 washes).
18. Make a solution of OPD, by putting the two tablets (in silver and gold foil) into 20 ml of distilled water (in a glass vial). Shake quite vigorously in the dark until the tablets have dissolved (Wrap the vial up either in tin foil or paper towel).
19. Add a small amount to the remaining solution from stage 16. Wait for a colour change (positive reaction). Add 200p1 to each well and incubate for a minimum of 30 minutes in the dark.
20. Read the plate at 450nm/405nm if filter not available.
Examples 1 to 26 The deactivants, as set out in the following table, were treated according to the above procedure and the results are as given below. Tannic acid was used as a comparator. What was measured after treatment with deactivant ant tannic acid was the amount of allergen active remaining after treatment. Also, the ratio of amount of active allergen remaining after treatment with deactivant is also given for some of the deactivants and active allergen remains after treatment with tannic acid.
Table
Example Deactivant Amount of active allergen Amount of active] remaining after deactivant Allergen remaining after no treatment deactivant treatment but only vaccuming 1 Glutaraldehyde 816 3375 2 Polymeric dialdehyde 2792 3375 3 Cedarwood oil 3375 6000 4 hexadecyltrimethylammonium chloride 2863 4992 5 Aluminium chlorohydrate 978 4992 6 1-propoxy-propanol-2 1233 4992 7 Silica Gel (Kent) 1540 4992 8 polyquaternium-10 (Polymer JR-125) 5463 6250 9 Propylene glycol alginate 3781 6250 10 Ammonium sulphate 2325 6250 11 Potassium thioglycolate 3092 3375
Example Deactivant Amount of active allergen remaining Amount of after deactivant treatment Allergen remaining after no deactivant treatment 12 Hinokitol (0.5%) 2058 3375 13 L-Ascorbic Acid 1438 5642 14 Immobilised Tannic Acid 1125 5642 15 Aerosol OT 4494 5642 16 Chlorohexidine 2281 4450 17 Parsley Camphor 2581 4450 18 Maleic anhydride 783 4450 19 Hinoki oil 1644 3400 20 Composite of AgCl and TiO2 1632 3400 21 Thymol 1500 3400 Further samples were tested as above and compared against tannic acid. The ratio of actives remaining after deactivant treatment and actives remaining after tannic acid treatment are given below: Deactivant Ratio of actives remaining after deactivant treatment over those remaining after tannic acid treatment Germall II 1.5 N-methyl 4.0 pyrrolidine Hinoki Oil 4.0 Silver 3.5 chloride/TO2 Thymol 4.0 Chlorohexidine 3.0 Maleic 1.0 anhydride Glutaraldehyde 1. 5 In the table certain compounds are used that are defined as follows: Polymeric dialdehyde is a compound containing 2-200 recurring units of the formula III.
Propylene glycol alginate is
Chlorohexadene is 1,1'-hexamethylene bis [5-(4-chlorophenyl)-biguanide Hinokitiol is -thujaplin, a compound of the formula
Aerosol OT is a compound of the formula
0 oZoc );Ooo;Oo) o Parsley extract is a compound of the formula
Hinoki oil is a mixture of Thujan-3-one, 2-pinene, 3,5,7,3',4' pentahydroflavanone and 1,3,3,trimethyl-2-norcamphanone.
Germall II is diazolidinyl urea and Thymol is 6-isospropyl -m- cresol Examples 27 to 30 The following formulations can be made up as a compositions for use as an aerosol for deactivating der-p allergens). EXAMPLE 27
Raw Ingredient Description Item Classification % By Weight Anhydrous Ethanol (SD Solvent Alcohol 40) 79.646 Alkyl dimethyl benzyl Cationic Surfactant ammonium saccharinate 0.106 Corrosion Inhibitor 0.192 Corrosion Inhibitor 0.192 Corrosion Inhibitor 0.096 Deionized Water Water/Solvent 15.768 Carbon Dioxide Propellant 4.000 TOTAL 100.000 EXAMPLE 28
Raw Ingredient Item Classification % Description by Weight Anhydrous Ethanol (SD Solvent * 57.000 Alcohol 40) Fragrance&num;17 Fragrance 0.0500 Dow Corning 193 Surfactant 0.025 Surfactant Corrosion Inhibitor 0.100 Corrosion Inhibitor 0.100 Deionized Water Water/solvent * 14.725 NP-40/Butane 40 Hydrocarbon 28.000 propellant TOTAL 100.000 * = May replace with 95% Ethanol (SD Alcohol 40) at 61.755% by weight and 9.970% by weight Deionized water EXAMPLE 29
Raw Ingredient Item Classification Description by Weight Anhydrous Ethanol (SD Solvent 79.646 Alcohol 40) Benzyl Benzoate Active/ester 4.600 - an acaricide Alkyl dimethyl benzyl Cationic Surfactant 0.106 ammonium saccharinate Corrosion Inhibitor 0.192 Corrosion Inhibitor 0.192 Corrosion Inhibitor 0.096 Deionized Water Water/solvent 11.168 Carbon Dioxide Propellant 4.000 TOTAL 100.000 EXAMPLE 30
Raw Ingredient Item Classification 8 Description by weight Anhydrous Ethanol (SD Solvent *57.000 Alcohol 40) Benzyl Benzoate Active/ester 4.600 Fragrance&num;17 Fragrance 0.0500 Dow Corning 193 Surfactant 0.025 Surfactant Corrosion Inhibitor 0.100 Corrosion Inhibitor 0.100 Deionized Water Water/solvent *10.125 NP-40/Butane 40 Hydrocarbon 28.000 propellant TOTAL 100.000 * = May replace 95% Ethanol (SD Alcohol 40) at 61.755% by weight and 5.370% by weight Deionized water.

Claims (1)

  1. CLAIMS 1. A method for deactivating a Der-p allergen comprising contacting the allergen with a deactivating effective amount of one or more of deactivants (herein after defined as the Deactivant) selected from
    i) cedarwood oil,
    ii) hexadecyltrimethylammonium chloride
    iii) aluminium chlorohydrate,
    iv) 1-propoxy-propanol-2,
    v) polyquaternium-l0
    vi) silica gel
    vii) potassium thioglycolate
    viii) propylene glycol alginate, ix) ammonium sulphate,
    x) hinokitiol,
    xi) glutaraldehyde,
    xii) L-ascorbic acid,
    xiii) "immobilised tannic acid", (hereinafter defined)
    xiv) chlorohexidine,
    xv) maleic anhydride,
    xvi) hinoki oil,
    xvii) a composite of AgCl and TiO2
    xviii)diazolidinyl urea, xix) 6-isopropyl-m-cresol,
    xx) a compound of formula I,
    0 0 0 I SocU (I) Nazis octyl o xxi) a compound of formula II
    xxii) a polymeric compound containing two or more of a recurring unit of the formula III
    where n = 2 to 200 2. A method according to Claim 1 in which the amount of Deactivant present is from 0.5 oz to 5 oz per 10 yds.
    3. A method according to Claim 1 or Claim 2 in which the Deactivant is selected from hinoki foil, a composite of AgC1 with TiO2, diazolidinyl urea and 6-isopropyl-m-cresol, chlorohexidine, N-methylpyrrolidone potassium thioglycolate and maleic anhydride glutaraldehyde hinokitiol silica gel cedarwood oil 1-propoxy-propanol-2 aluminium chlorohydrate immobilised tannic acid, and L-ascorbic acid 4. An aerosol composition containing a) a deactivant selected from
    i) cedarwood oil,
    ii) hexadecyltrimethylammonium chloride
    iii) aluminium chlorohydrate,
    iv) 1-propoxy-propanol-2,
    v) polyquaternium-l0
    vi) silica gel
    vii) potassium thioglycolate
    viii) propylene glycol alginate,
    ix) ammonium sulphate,
    x) hinokitiol,
    xi) glutaraldehyde
    xii) L-ascorbic acid,
    xiii) "immobilised tannic acid, (hereinafter defined)
    xiv) chlorohexidine,
    xv) maleic anhydride,
    xvi) hinoki oil, xvii) a composite of silver chloride and TiO2 xviii) diazolidinyl urea, xix) 6-isopropyl-m-cresol, xx) a compound of formula I,
    0 000octyI (I) Na3OS 0octyI and
    xxi) a compound of formula II
    and xxii) a polymeric compound containing two or more of a recurring unit of the formula III
    where n = 2 to 200 (hereinafter defined as the Deactivant). b) a propellant and c) optionally a solvent.
    6. A composition according to Claim 5 in which the amount of Deactivant present in such a composition is from 0.01 to 7%, the amount of propellant present in such a composition is 0.05 to 3%, and the amount of solvent present in such a composition is O to 99.95%.
    7. A composition according to Claim 5 or Claim 6 in which the Deactivant is selected from hinoki oil, a composite of AgCl with TiO2, diazolidinyl urea, 6-isopropyl-m-cresol chlorohexidine, maleic anhydride, N-methyl pyrrolidine potassium thioglycolate hinokitiol silica gel cedarwood oil 1-propoxy-propanol-2-01 aluminium chlorohydrate immobilised tannic acid, and L-ascorbic acid 8. A composition according to any one of Claims 4 to 7 in which the propellant is selected from Cl4alkane and carbon dioxide.
    9. A composition according to any one of Claims 4 to 8 in which the solvent is selected from C16 alcohols (e.g. ethanol) or water.
    10. A composition according to any one of Claims 4 to 9 in which the composition may also contain one or more of the following a fragrance, a surfactant (e.g. Dow Corning 193 Surfactant an antimicrobial agent (e.g.alkyl dimethyl benzyl ammonium saccharinate), a corrosion inhibitor (e.g. sodium nitrite, sodium benzoate, triethanolamine and ammonium hydroxide), and/or a miticide (such as benzyl benzoate).
    11. A method for denaturing a Der-p allergen substantially as herein described with reference to any one of the Examples.
    12. A composition substantially as herein described with reference to any one of the Examples.
GB9720298A 1997-09-25 1997-09-25 House dust mite allergen deactivation Withdrawn GB2329587A (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
GB9720298A GB2329587A (en) 1997-09-25 1997-09-25 House dust mite allergen deactivation
GB9820220A GB2329588B (en) 1997-09-25 1998-09-18 Deactivants for dust mite allergens
DE69829698T DE69829698T2 (en) 1997-09-25 1998-09-22 Deactivator for house dust mite allergens
CA2695678A CA2695678C (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
EP02003296A EP1219323B1 (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
DE69830256T DE69830256T2 (en) 1997-09-25 1998-09-22 Deactivator for house dust mite allergens
ES04020020T ES2323460T3 (en) 1997-09-25 1998-09-22 ACAROS DUST ALLERGEN DEACTIVANTS.
AU91752/98A AU9175298A (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
DE69840760T DE69840760D1 (en) 1997-09-25 1998-09-22 Deactivator for house dust mite allergens
US09/509,308 US6800247B1 (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
EP98944081A EP1017428B1 (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
ES02003296T ES2239181T3 (en) 1997-09-25 1998-09-22 ACAROS DUST ALLERGEN DEACTIVATORS.
PCT/GB1998/002863 WO1999015208A2 (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
ES98944081T ES2197503T3 (en) 1997-09-25 1998-09-22 DEACTIVATING AGENCIES OF DOMESTIC POWDER ALLERGENS.
EP04018315A EP1498156A3 (en) 1997-09-25 1998-09-22 Use of compounds in deactivating dust mite allergens
ES02003297T ES2239694T3 (en) 1997-09-25 1998-09-22 DEACTIVATING AGENTS OF DUST ACAROS ALLERGENS.
EP04020020A EP1484089B1 (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
DE69814427T DE69814427T2 (en) 1997-09-25 1998-09-22 DEACTIVATING AGENT FOR HOUSE DUST MALLENGE ALLERGENS
EP02003297A EP1224955B1 (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
CA2304639A CA2304639C (en) 1997-09-25 1998-09-22 Deactivants for dust mite allergens
ARP980104774A AR017145A1 (en) 1997-09-25 1998-09-24 A METHOD FOR DEACTIVATING A DER-F AND / OR DER-P ALLERGEN FROM A TEXTILE SURFACE
AU2003200400A AU2003200400B2 (en) 1997-09-25 2003-02-06 Deactivants for dust mite allergens
US10/911,895 US20050008579A1 (en) 1997-09-25 2004-08-05 Deactivants for dust mite allergens
US10/912,000 US7537729B2 (en) 1997-09-25 2004-08-05 Deactivants for dust mite allergens
AU2006252279A AU2006252279B2 (en) 1997-09-25 2006-12-28 Deactivants for dust mite allergens
AU2010200851A AU2010200851B2 (en) 1997-09-25 2010-03-05 Deactivants for dust mite allergens

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062354A1 (en) * 2001-02-08 2002-08-15 The Procter & Gamble Company Allergen neutralization compositions containing aluminum ions
US7192610B2 (en) 2000-04-07 2007-03-20 Reckitt Benckiser (Uk) Limited Method of deactivating dust mite allergens
US7704532B1 (en) 2001-07-11 2010-04-27 Smith C Steven Method for altering allergenic protein in the environment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009762A1 (en) * 1994-09-28 1996-04-04 Laboratoires Phytodif Method for controlling the allergenicity of house dust mites and their dejecta
GB2300122A (en) * 1995-04-25 1996-10-30 Sinclair Animal & Household Ca House dust mite allergen control

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009762A1 (en) * 1994-09-28 1996-04-04 Laboratoires Phytodif Method for controlling the allergenicity of house dust mites and their dejecta
GB2300122A (en) * 1995-04-25 1996-10-30 Sinclair Animal & Household Ca House dust mite allergen control

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192610B2 (en) 2000-04-07 2007-03-20 Reckitt Benckiser (Uk) Limited Method of deactivating dust mite allergens
WO2002062354A1 (en) * 2001-02-08 2002-08-15 The Procter & Gamble Company Allergen neutralization compositions containing aluminum ions
US7704532B1 (en) 2001-07-11 2010-04-27 Smith C Steven Method for altering allergenic protein in the environment

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