US20050004559A1 - Universal medical device control console - Google Patents

Universal medical device control console Download PDF

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Publication number
US20050004559A1
US20050004559A1 US10/847,699 US84769904A US2005004559A1 US 20050004559 A1 US20050004559 A1 US 20050004559A1 US 84769904 A US84769904 A US 84769904A US 2005004559 A1 US2005004559 A1 US 2005004559A1
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US
United States
Prior art keywords
medical device
module
control
consol
control consol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/847,699
Other languages
English (en)
Inventor
Richard Quick
Martin Shabaz
James Dabney
Daniel Kussman
Frank Louw
Paul Lubock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SenoRx Inc
Original Assignee
SenoRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/847,699 priority Critical patent/US20050004559A1/en
Application filed by SenoRx Inc filed Critical SenoRx Inc
Priority to EP04753041.5A priority patent/EP1628580B1/en
Priority to AU2004244989A priority patent/AU2004244989B2/en
Priority to JP2006514932A priority patent/JP2007525246A/ja
Priority to ES04753041T priority patent/ES2428357T3/es
Priority to CA2527233A priority patent/CA2527233C/en
Assigned to SENORX, INC. reassignment SENORX, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SHABAZ, MARTIN V., QUICK, RICHARD L., DABNEY, JAMES H., KUSSMAN, DAN, LOUW, FRANK R., LUBOCK, PAUL
Publication of US20050004559A1 publication Critical patent/US20050004559A1/en
Priority to US11/980,956 priority patent/US8652121B2/en
Priority to US12/220,389 priority patent/US8696650B2/en
Priority to US12/229,793 priority patent/US8882760B2/en
Priority to US12/229,794 priority patent/US9517104B2/en
Priority to US14/161,218 priority patent/US10912541B2/en
Priority to US14/533,684 priority patent/US10278763B2/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0233Pointed or sharp biopsy instruments
    • A61B10/0266Pointed or sharp biopsy instruments means for severing sample
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0233Pointed or sharp biopsy instruments
    • A61B10/0283Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/01Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024Detecting, measuring or recording pulse rate or heart rate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00199Electrical control of surgical instruments with a console, e.g. a control panel with a display
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00225Systems for controlling multiple different instruments, e.g. microsurgical systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00477Coupling
    • A61B2017/00482Coupling with a code
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00796Breast surgery
    • A61B2017/008Removal of tumors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00973Surgical instruments, devices or methods, e.g. tourniquets pedal-operated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06Measuring instruments not otherwise provided for

Definitions

  • the present invention relates generally to medical devices, and more particularly to a universal control consol for operating with a variety of medical devices. Still more particularly, the present disclosure relates to the design of a universal medical equipment control consol that interfaces with a variety of handheld medical instruments, and the method to control the same.
  • Conventional medical equipment design typically requires separate, dedicated hardware and software control modules for each handheld medical device. Each of these devices requires a graphical display, microprocessor, interface circuitry and software to operate the medical device, and to provide the operator with pertinent status/action information.
  • An “operator” is defined as any medical personnel capable of operating the medical device. The operator may be a nurse, a medical doctor, or a medical assistant.
  • GUI graphical user interface
  • a universal medical equipment control consol that interfaces with a variety of medical devices.
  • This disclosure will provide a detailed description of how a medical device interacts with the universal medical equipment control consol. Additional medical devices may be implemented. This concept allows for a universal control consol with all the necessary hardware interface modules and software modules that can control a variety of medical devices, thereby eliminating the need for separate, dedicated control hardware for each medical device.
  • This universal control consol will provide a graphical user interface (GUI) for all devices that would decrease the need for operator training and certification requirements while increasing the simplicity of operation. Additional benefits include reduced surgical space, storage space, and inventory logistics costs. Some advanced models of the universal control consol may have the ability to handle multiple devices simultaneously.
  • GUI graphical user interface
  • a control consol for controlling one or more medical devices.
  • the control consol communicates to at least one medical device and, if needed, at least one peripheral device module associated with the medical device.
  • the control consol is microprocessor based for directing an operation of the connected medical device.
  • FIG. 1A is a schematic diagram illustrating a universal control consol which embodies features of the invention operating with a plurality of medical devices.
  • FIG. 1B is a schematic diagram illustrating a universal control consol which embodies features of the invention operating with a plurality of medical devices and peripheral modules through a housing module.
  • FIG. 2 illustrates the major components of the universal control consol shown in FIG. 1A or 1 B.
  • FIG. 3 illustrates a frontal view of the universal control consol shown in FIG. 1A embodying features of the invention.
  • FIG. 4 illustrates a rear view of the universal control consol shown in FIG. 1A embodying features of the invention.
  • FIG. 5 presents a flowchart illustrating the relationship between various Graphical User Interface (GUI) display screens embodying features of the invention.
  • GUI Graphical User Interface
  • FIG. 6 represents various display screens for the universal control consol embodying features of the invention.
  • FIG. 7 illustrates a flowchart illustrating an interactivity between various software components of the universal control consol embodying features of the invention.
  • FIG. 8 illustrates a design embodying the interaction between a biopsy device and the universal control consol.
  • FIG. 9 illustrates the biopsy device.
  • FIG. 10A presents a flowchart illustrating the operating states of the universal control consol with the biopsy device in accordance with one example of the present invention.
  • FIGS. 10B to 10 D present various display screens in relation to the states in FIG. 10A in accordance with one example of the present invention.
  • FIGS. 11A and 11B represent a probe failure processing flowchart and its corresponding display screen in accordance with one example of the present invention.
  • FIG. 12 present the display screens in the tool error state in accordance with one example of the present invention.
  • FIGS. 13A and 13B present a ESG failure processing flowchart and its corresponding display screens in accordance with one example of the present invention.
  • FIGS. 14A and 14B present a vacuum failure processing flowchart and its corresponding display screens in accordance with one example of the present invention.
  • FIGS. 15A and 15B present a tool exit processing flowchart and its corresponding display screens in accordance with one example of the present disclosure.
  • FIG. 1A presents a diagram 100 illustrating the relationship between the universal control consol 102 and a plurality of medical devices 104 , 106 or 108 in accordance with one example of the present disclosure.
  • Devices 104 , 106 and 108 represent some of the many individual medical devices that may connect or communicate to the universal control consol 102 via a connector 110 or via wireless communication links.
  • Many of the medical devices are controllable by a computer based operating tool so that the universal control consol can communicate and control the medical device in many ways without human interaction.
  • the term “connected” may also mean that they can be connected wirelessly without physically connected through wires.
  • the universal control consol 102 may also have a bypass mode in which a medical device may not be connected.
  • the universal control consol 102 may interface with and control the functions of any one of the devices 104 , 106 and 108 via the connector 110 .
  • each of the devices 104 , 106 , and 108 may represent a biopsy probe, temperature probe, heart rate monitor device, drug infusion tools, anesthesia tools, or other surgical or medical device that may operate with the universal control consol 102 .
  • These devices may serve various surgical or non-surgical functions such as separating specimen from tissue bed, encapsulating the separated specimen, insulating a cutter from body, fixing one end of a cutter while S 5 moving another end thereof.
  • These devices may be made by or operated with products of SenoRx of Aliso Viejo, Calif. such as the SenoCor Biopsy Device and the EnCor Biopsy Device.
  • the surgical devices may be energized mechanically or through radio frequency (RF) energy for performing the surgery.
  • RF radio frequency
  • a RF surgical tool uses RF energy to remove unwanted body parts while the same function may be achieved by a mechanical tool such as a blade.
  • Each of these medical devices may require a unique set 112 of peripheral modules 114 , 116 and 118 , which are connectable to and controlled by the universal control consol 102 via connectors 120 , 122 and 124 , respectively.
  • the device 104 may be a biopsy probe, which in turn may require a plurality of peripheral modules 114 , 116 and 118 , which further in turn may be an electro surgical generation (ESG) module, an illumination device, a footswitch module, and a vacuum/fluid pump module.
  • ESG electro surgical generation
  • peripheral modules provides additional features or functions for the operation of the medical device, and can be of different forms and functions, and they may not be required to be physically connected to the universal control consol as long as they can communicate therewith.
  • the peripheral devices are controlled by the medical device through the universal control consol.
  • the universal control consol 102 is a microprocessor-based electrical device with built-in software functions necessary to operate various medical devices.
  • Each medical device contains a software script, stored in a memory device within the medical device for operating that particular device when connected to the universal control consol 102 .
  • the said software script may be stored in non-volatile memories such as erasable programmable read only memories (EPROMs), electrically erasable programmable read only memories (EEPROMs) or flash memories.
  • EPROMs erasable programmable read only memories
  • EEPROMs electrically erasable programmable read only memories
  • flash memories such as erasable programmable read only memories (EPROMs), electrically erasable programmable read only memories (EEPROMs) or flash memories.
  • GUI Graphical User Interface
  • the control of the medical devices by the universal control consol 102 can be easily implemented through wireless communications. Needless to say, certain peripheral devices may have to be physically connected to the medical device to deliver fluid or assert vacuum.
  • the conventional wired connections have certain advantages such as low signal interferences, but the wireless technology can turn the operation of the medical device to mobile operation, which benefits the operator as well. For example, other than the power output provided by the universal control consol 102 , almost all the control signals can be sent through a predetermined wireless communication channel using technologies such as Bluetooth or 802.11 compliant wireless technologies. When the medical device is battery powered, then the operation may be all mobile.
  • wired communication channels may be used together with the wireless communication channels so that the universal control consol can take advantage of the available wireless technologies for providing convenience to the operator, while still benefiting from using some conventional wired technologies.
  • analog signals used in the communications can be replaced by digital signals if appropriate since the digital signal processing technology has also advanced.
  • communications between devices can take various forms and the universal control consol 102 is designed to use the most practical technologies for fulfilling the need of the operators.
  • a housing module may also be provided to house, and to supply electrical power to, some of the aforesaid modules and equipments.
  • FIG. 1B is a schematic diagram 126 illustrating the relationship among a housing module 128 , the universal control module 102 and the unique set 112 of peripheral modules 114 , 116 and 118 .
  • the housing module 128 includes a power strip 130 , which connects, via a power cord 132 , to an electrical power source, such as a 220-240V AC power source.
  • the power strip 130 is utilized to distribute electrical power to a plurality of modules and equipments.
  • a line cord 134 may be utilized to deliver electrical power from the power strip 130 to the universal control module 102 .
  • a plurality of line cords 136 , 138 and 140 may also be utilized to deliver electrical power from the power strip 130 to the peripheral modules 114 , 116 and 118 , respectively.
  • the housing module 128 may provide docking stations (not shown) for the handheld medical devices 104 , 106 and 108 .
  • the housing module 128 can be a cart or a portable cabinet; that the power strip 130 and the aforesaid modules are fixed-mounted or screw-mounted onto the housing module 128 ; that the housing module 128 includes a plurality of moving wheels and accessible handles; and that the housing module 128 includes a wire latch that organizes and secures a plurality of line cords and data cables.
  • the housing module 128 functions as an organizer, a power distributor and an ergonomic solution for the operator to access the plurality of modules and equipments.
  • FIG. 2 illustrates several components of the universal control consol 102 .
  • the universal control consol 102 includes a graphics module 202 , a microprocessor module 204 , a software module 206 , a hardware interface module 208 , an operator module 210 and a power module 212 .
  • the graphics module 202 may include a cathode ray tube (CRT) display, a liquid crystal display (LCD) or any other type of display that may be used to display information relevant to the operation of the universal control consol 102 and medical devices.
  • the graphics module 202 may also require a piece of Graphical User Interface (GUI) software that is used to display all pertinent information to the operator.
  • GUI Graphical User Interface
  • the microprocessor module 204 may include microprocessors, motherboard circuitries, memories and other functional electronic devices that enable the universal control consol 102 , the operator controls thereof, the functions of medical device, and the functions of peripheral modules. It may also interface with an external computer via an external computer interface connector for system troubleshooting, software upgrade, and other shop functions.
  • the software module 206 controls the logical and interface functions of the universal control consol 102 , the logical and interface functions of the medical devices attached thereto, the logical and interface functions of the peripheral modules attached thereto, and the operator control switches therein.
  • the software module 206 may also generate various control signals such as audible tones (for example, sounds of Bong, Click, and Alarm) that are applied to a speaker located within the universal control consol 102 .
  • the Bong and Click tones may be adjustable by a predetermined setting. Depending on software specification, the alarm tone may or may not be adjustable.
  • the software may be written in “C” code, although it is understood by those skilled in the art that various other software languages may be used to write the software for the universal control consol 102 .
  • the software module 206 may include any combination of the following: core software operating the universal control consol 102 , GUI software for presenting graphics in the graphics module 202 , built-in self-test (BIST) software, and software for controlling and interfacing with medical devices and peripheral modules.
  • core software operating the universal control consol 102 GUI software for presenting graphics in the graphics module 202
  • BIST built-in self-test
  • Each medical device when connected to the universal control consol 102 , may download a software script. This software script will allow for the control of the particular medical device functions and display its pertinent information.
  • the hardware interface module 208 may include circuitries and connecting modules necessary to allow medical devices or peripheral modules to be connected to the universal control consol 102 .
  • These connecting modules may be general connectors compliant with various well-known standards, including but not limited to Institute of Electrical and Electronics Engineers (IEEE) standards and International Organization of Standardization (ISO) standards. These connectors may also be proprietary connectors specific to a particular medical device or peripheral modules, or a particular line of medical devices or peripheral modules.
  • the connecting modules may be a circuitry for communicating wirelessly with a device controlled by the universal control consol.
  • the hardware interface module 208 may have a computer interface connector.
  • the computer interface connector is used for system troubleshooting, software upgrades, and other shop functions. This connector contains connectors for RS-232 communication, connectors for background debug mode (BDM), and connectors for other shop activities.
  • the hardware interface module 208 may have an AC power input connector, which may be a three-wire connector connectable to 100-120 VAC and/or 220 - 240 VAC, at 50-60 Hz.
  • the hardware interface module 208 may have an AC power output connector, which is connectable to other peripheral equipments and which provides the other equipments with AC power.
  • the hardware interface module 208 may have a DC power output connector, which is connectable to other peripheral equipments and which provides the other equipments with DC power. It is understood that either DC or AC power can be delivered to an illumination device such as a light bulb or any surgical lighting device attached to or integrated with a medical device such as a biopsy probe used with the control consol.
  • the control consol may provide further remote operation control for the illumination device.
  • the universal control consol 102 may depend upon the medical devices and its associated peripheral equipment that have been certified to operate with the universal control consol 102 . As additional medical devices are selected, upgrades to the hardware and software may be required. Since analog and digital signals may co-exist in various operations, the universal control consol may have analog-to-digital (A/D) converters or even digital-to-analog (D/A) converters contained therein for processing various signals coming in or going out from the universal control consol.
  • A/D analog-to-digital
  • D/A digital-to-analog
  • the biopsy probe may require an ESG module, a footswitch module, and a vacuum pump module.
  • the biopsy probe and its associated peripheral modules in turn may require the following interface connectors: a medical device connector, an ESG connector, a footswitch connector, and a vacuum pump connector.
  • the medical device connector may contain a plurality of copper wires for bi-directional digital communications, EEPROM communication, encoder functions, light emitting diode (LED) & relay control, motor control, power, and ground.
  • the ESG connector may provide bi-directional communication for the control and status of the ESG module and the universal control consol 102 , and may include a RS- 485 data bus for status communication.
  • the footswitch connector may pass information from the footswitch module to the universal control consol 102 , thereby allowing the operator to control the ESG module and the universal control consol 102 by the tapping of the foot.
  • the vacuum pump connector may provide data and control information between the vacuum system and universal control consol 102 . It may contain system data and clock lines, vacuum level and control lines, and status lines.
  • the operator module 210 may include various pushbutton switches and indicators that assist the operator to operate the universal control consol 102 .
  • various pushbutton switches and indicators that assist the operator to operate the universal control consol 102 .
  • the function of the switches may be dependent upon the display screen at a particular instance.
  • the display screen displays the required actions and what action may be activated with a particular switch at a given instance.
  • the operator module 210 may have two indicator lights, one of which is an orange standby indicator light on the front panel that may be activated when the rear mounted power switch is depressed and the system enters a standby state, while the other of which is a green indicator light on the front panel that may be activated when a front mounted power switch is depressed for a minimum of 2 seconds, thereby signaling the universal control consol 102 to kick-start its boot up sequence.
  • the display may indicate that the universal control consol 102 is in the process of shutting down.
  • the universal control consol 102 may complete any actions required by the medical device, save any required settings, and then return to the standby mode.
  • the power module 212 may include a transformer, AC power input and output connectors, a power system, fuse, and a power switch.
  • the power module 212 may supply power to the rest of the universal control consol 102 , and may supply power to other peripheral modules and medical devices attached thereto.
  • FIG. 3 illustrates a frontal and top view 300 of the universal control consol 102 embodying features of the present invention.
  • the front of the case enclosure 302 includes a graphical display screen 304 , various operator control switches 306 , a medical device connector 308 , a front power switch 310 , an orange “standby” indicator light 312 , and the green “on” light 314 .
  • the connector 308 is an example for a connecting module which either physically connects to a device or wirelessly communicates to a device without any physical connection existing therebetween.
  • FIG. 4 illustrates a rear and bottom view 400 of the universal control consol 102 shown in FIG. 3 .
  • the rear of the case enclosure 402 includes a power module 404 , a footswitch connector 406 , a vacuum connector 408 , an ESG connector 410 , spare connectors 412 for future medical device/peripheral equipment additions, and the external computer interface connector 414 behind the removable panel 416 .
  • the power module 404 includes the input power connector 418 , output power connector 420 , AC power fuse 422 , and the rear power switch 424 .
  • the bottom of the enclosure 402 includes the alarm speaker 426 for the Bong, Click, and Alarm tones.
  • FIG. 5 presents a flowchart 500 illustrating the relationship between various display screens, which are referred to and shown in FIG. 6 , in accordance with one example of the present disclosure.
  • the flowchart 500 illustrates the software flowchart covering the initial boot-up, medical device connection, utility mode setup, boot-up alarm sequence and the downloading of the medical device script.
  • a general high-level software flow 502 illustrates how the software module generally handles any medical device that is connected to the universal control consol 102 . This software flow may be unique for each medical device operation.
  • the flowchart 500 begins at a boot-up process 504 that occurs when the power-on sequence is started.
  • the universal control consol 102 checks the shop mode jumper to determine if the system should go into the shop mode for troubleshooting/upgrade, as illustrated by box 508 , or continue the normal boot-up process.
  • a decision box 510 determines whether a language selection screen should be displayed to the operator to select the desired operator language. If the language selection screen should be displayed, a language screen, which may look like the screen 602 , may be displayed. This selection is accomplished through the use of the pushbutton switches located adjacent to the graphical display screen. The universal control consol software script controls the functions of these switches. Once the desired language is selected, a boot-up splash screen that may look like the screen 604 is displayed.
  • the script will go directly to download the medical device script, and a screen that may look like the screen 606 is displayed to the operator. If an alarm is generated during the boot-up process, the script will transfer to the boot-up alarm screen 608 to ask the operator to reset the system. If no medical device has been connected, a bypass mode screen that may look like the screen 610 may be displayed, wherein the operator is asked to connect the medical device or to access the utility menu. If the operator connects the medical device, then the script goes directly to the device script download mode and the screen 606 may be displayed. If the operator wishes to enter the utility mode, then the operator depresses the “SELECT” pushbutton switch, thereby switching to the utility screen, which may look like the screen 612 .
  • the utility menu allows the operator to adjust the volume level, which may be accomplished in a volume level screen that may look like the screen 614 , to adjust the display screen intensity level, which may be accomplished in a display screen intensity level screen that may look like the screen 616 , or to go back to the screen 610 such that the operator may connect the medical device.
  • the operator is transferred back to the bypass mode screen.
  • the script goes directly to the device script download mode and screen 606 may be displayed.
  • the downloaded script controls the universal control consol 102 and its display as determined by the type of medical device connected.
  • the connected medical device determines the system operation and display screens.
  • the appropriate control configuration of a medical device is managed by the universal control consol 102 .
  • it detects and configures itself to match the operating configuration of the medical device.
  • it detects and provides an appropriate voltage supply for operating the medical device. It may also provide control signals to control the motor in the medical device.
  • It may provide appropriate GUI windows to the operator with regard to the medical device so that the operator only needs to deal with relevant GUI windows for operating the medical device. If a vacuum pump is needed to be used in conjunction with the medical device, it not only will indicate to the operator whether a vacuum pump is properly connected, it will also provide the appropriate operating voltage to the vacuum pump.
  • the universal control consol 102 is to assist the operator to operate multiple medical devices with ease. To the extent possible, all configurable items for operating the medical device are either automatically provided to the device or prompted to the operator to be chosen so that they can be then provided to the connected device.
  • the three pushbutton switches are utilized in the displays that require an operator action, such as language selection, volume adjust, reset, etc. It is understood by those skilled in the art that all display screens in FIG. 6 are presented to illustrate the spirit of the invention, are subject to change, and are not considered to be the only version.
  • FIG. 7 presents a flowchart 700 illustrating the high level interactivity between various software components of the universal control consol 102 in accordance with one example of the present disclosure.
  • the components include a main module 702 , a tool-code module 704 , an application program interface (API) module 706 , a core software module 708 that in turn includes a self-test module 710 and a GUI module 712 , a control software module 714 that in turn includes a communication control module 716 , a vacuum pump control module 718 and a motor control module 720 , a RF control module 721 , and a binary I/O module 722 .
  • API application program interface
  • the main module 702 contains software functions for the operation. For example, it includes a reset function in assembly code that is required to start the controller and run a portion of the self-test.
  • the main module 702 also includes a high-level code that runs the main loop and performs some additional self-tests, including memory and processor tests.
  • the tool-code module 704 loads the tool code from nonvolatile memories into the code buffer of the volatile memories and then runs tests thereon.
  • the tool code may be tested by a variety of methods. For example, one tool code testing method is by using cyclic redundancy check (CRC).
  • CRC cyclic redundancy check
  • the tool-code module 704 may also allow the universal control consol 102 to write to nonvolatile memories.
  • tool-code module 704 may include the testing of nonvolatile memories. In other words, the tool-code module 704 may run periodic tests to ensure that nonvolatile memories are not corrupted.
  • the API module 706 may include an API called by the tool code, and an API manager that is used to manage the said API.
  • the API is used by the tool-code module 704 to request the universal control consol 102 to act in a certain manner.
  • one implementation strategy may call for the use of software interrupts to request certain API routines, via the API module 706 .
  • the self-test module 710 may include built-in, self-test (BIST) software that is used to perform various self-testing operations. Most of these self-testing operations should be non-invasive, i.e., they should test for mis-configuration, but should not actively induce one.
  • BIST self-test
  • the GUI module 712 may include software that is used to draw outputs to the screen. This GUI module 712 may also include functions such as the initialization of the color palette upon boot-up, the drawing of the first splash display screen, and the refreshing of subsequent display screens.
  • the communication control module 716 may include software that controls the inputs and outputs through the RS- 485 connector.
  • the communication control module 716 keeps all information about a port in a table, which is typically indexed to ensure fast referencing.
  • the interrupt callback routines of the communication control module 716 may be passed to a hardware access layer, thereby enabling the universal control consol 102 to receive incoming data.
  • the vacuum pump control module 718 may include software that controls the vacuum pump system interface.
  • the vacuum pump control module 718 may be able to detect vacuum and pump power. It may also be able to translate commands sent by the universal control consol 102 to actual pressure, and vice versa.
  • the motor control module 720 may include software that controls the motors located in the medical device.
  • the motor control module 720 may provide the universal control consol 102 with various operating modes.
  • the motor control module 720 may provide a feedback-controlled operating mode, which may employ a variety of discrete proportional-integral-derivative (PID) feedback algorithms to provide feedback functionality.
  • PID discrete proportional-integral-derivative
  • the motor control module 720 may also provide various constant operating modes, including constant current and constant voltage operating modes, which may be necessary for medical devices that require a steady motor.
  • the RF control module 721 is dedicated to control devices using RF energy.
  • the binary I/O module 722 may include software that performs the binary input and output. For example, the binary I/O module 722 maps an array of binary outputs to its corresponding array of hardware address registers, and writes data flags to the latter. For example, when the “power-off” button is pressed, the binary I/O module 722 first searches for and locates the corresponding hardware address register, and then begins a power-off sequence. In another example, when a motor is stopped, the binary I/O module 722 may read the corresponding hardware address and return a flag indicating that the particular motor has been stopped.
  • the universal control consol embodying features of the present invention may be operated in regular ambient temperature and usually requires no special sterilization.
  • the operating voltage may be from 100 to 240 VAC with corresponding standard current limits. It also meets other industry required environmental conditions such as the CISPR 11 or IEC 60601-1-2:2001 for electromagnetic generation and IEC601-2-2 Section 44.3 for drip, splash and immersion requirement. It also meets various international standards including various safety requirements for medical equipments in different countries such as Japan, Canada, EU, and US.
  • FIG. 8 illustrates a design 1000 embodying the interaction between a biopsy device 1002 , as further illustrated in FIG. 9 , and the universal control consol 102 in accordance with one example of the present disclosure.
  • the medical device such as a biopsy device 1002 consists of the SenoCor DR3000 biopsy driver 1004 and a surgical element such as the SenoCor 360 biopsy probe 1006 .
  • the biopsy probe 1006 and biopsy driver 1004 when used in conjunction with the universal control consol 102 , a VS3000 vacuum system 1008 and a SenoRx ES300 ESG module 1010 , are designed to obtain breast tissue biopsy samples.
  • the specifications of SenoCor DR3000, SenoCor 360 , VS3000 and SenoRx ES300 may be found at SenoRx's website, at:
  • the universal control consol 102 is connected from the medical device connector 308 , via a control cable 1012 , to the biopsy driver 1004 .
  • the universal control consol 102 may provide user interface, motor speed control, and operator feedback for the biopsy driver 1004 .
  • the embodying design 1000 provides many features, four of which are highlighted below:
  • the biopsy probe 1006 that attaches to the biopsy driver 1004 incorporates a disposable RF cutting tip.
  • the RF cutting tip enables the device to slide easily through difficult heterogeneous breast tissue, and to penetrate through dense lesions, thereby improving the targeting capability of the device.
  • RF energy is developed by the ESG module 1010 , which is controlled by a dual footswitch 1014 and the universal control consol 102 .
  • the generator-enable signal is routed from the footswitch 1014 via a cable 1016 to the connector 406 , and then through the ESG connector 410 via a cable 1018 to a footswitch input connector on the ESG module 1010 .
  • the cable 1018 which may be designed for RS485 communication, provides a communication path to allow the universal control consol 102 to configure the ESG module 1010 for the biopsy device 1002 .
  • the RF output from the ESG module 1010 is fed, via a RF cable 1024 , to a RF cable connector 1026 of the biopsy driver 1004 .
  • the patient return pad 1028 is connected to the ESG module 1010 via a cable 1030 .
  • the disposable biopsy probe 1006 consists of an inner cutting trocar and sample chamber with an outer probe.
  • a trocar is a sharply pointed surgical instrument fitted with a probe and used to insert the probe into a body cavity, typically, as a drainage outlet.
  • An outer probe is typically a small tube for insertion into a body cavity. After a lesion has been targeted, the outer probe remains in place while the inner sample chamber is removed following the removal of a biopsy specimen.
  • the above functions are generated by DC motors in the biopsy driver 1004 that provide linear or rotary motions for the disposable biopsy probe 1006 .
  • Medical devices may contain up to four DC motors and each motor is driven by a DAC output located in the universal control consol 102 . These signals and the other required signals are routed through the medical device connector 308 and the control cable 1012 to the biopsy driver 1004 .
  • the device 1002 harvests tissue from a full 360-degree radius, thereby enabling harvesting of tissue directly from the center of the suspicious mass. This process is assisted by the use of the vacuum switch located on the driver 1004 to remove any excess fluid from the biopsy area. Vacuum is applied by the vacuum system 1008 to a vacuum tube connector 1034 of the biopsy driver 1004 via a vacuum tube 1036 . The vacuum system 1008 is under the control of the universal control consol 102 via a cable 1038 , which connects to the vacuum connector 408 .
  • the biopsy device 1002 includes the biopsy driver 1004 and the biopsy probe 1006 , and incorporates three easy to'use push buttons: “sample”, “vacuum”, and “eject”.
  • sample the operator pushes the “sample” button 1102 .
  • vacuum the operator pushes the “vacuum” button 1104 .
  • certain functional key or unlocking mechanism such as the “eject” button 1106 , after which the disposable probe is easily removed.
  • probe size e.g., diameter
  • the actions associated with the said buttons may differ in different probe designs, dependent upon functional and software control requirements.
  • the connector 308 is a 56-pin connector, with shielded cable and with non-isolated I/O.
  • the inputs from the medical device is preferred to have six digital wires (switches or position sensors) as well as eight encoder wires (two signals lines per encoder).
  • the outputs to the medical device in this example contain four wires for power (+12VDC, ⁇ 12VDC, +5VDC, ground), six digital wires for LED indicators and relay controls, and eight wires for motor drive control (two wires per motor).
  • the medical device is preferred to have up to 4 DC motors.
  • the universal control consol 102 may provide 12-bit DAC outputs for each motor. There is a maximum of 2 Amps for all four motors.
  • Each motor can draw up to 1 Amp, and maintain a 2 Amp-limit on all four motors.
  • eight wires are used for EEPROM communication, two wires may be used for grounds (one for shield, the other for connector case), and five spare wires are included for future expansion. It is understood that various types of motors can be used by different medical devices, and the universal control consol 102 can implement appropriate connectors for controlling the medical device with special requirement for the connector.
  • the connector 406 is a 12-pin connector, with shielded cable and with isolated I/O.
  • the footswitch may use two wires for the active signals, one wire for the common return signal, one wire for a shielded signal and eight spare wires for future expansion.
  • the ESG connector 410 is a 15-pin connector, with shielded cable and with isolated I/O.
  • the connector 410 may contain inputs and output to and from the ESG module 1010 for communicating its status or configuring the ESG module 1010 using a RS-485 communication bus;
  • the connector 410 may also contain several spare wires for future expansion.
  • the connector 408 is an 18-pin connector, with shielded cable and with isolated I/O.
  • the connector uses two wires for vacuum system data and clock.
  • the inputs contain four bits for vacuum level plus two bits for control. Also included are wires that carry power-on and vacuum-ready status signals.
  • the external computer interface connector 414 is a 14-pin connector, with non-shielded cable and with non-isolated I/O. It contains 10 wires for BDM communication, three wires for RS-232 communication, and one wire for the shop mode switch that is in turn used for system troubleshooting and/or upgrade.
  • the connector 418 is a 3-pin connector, with a non-shielded, removable cord.
  • the input power may be 100/220 VAC, at 50 or 60 Hz, with a 2 Amps maximum input limit.
  • the connector 420 is a 3-pin connector, with a non-shielded, removable cord.
  • the output power may be 100/220 VAC, at 50 or 60 Hz.
  • the device 1002 has the following components that are controlled by the software script downloaded into the universal control consol 102 :
  • the stroke motor controls the axial motion of the cutting sleeve of the device 1002 .
  • the motor is in turn controlled by the motor control module 720 .
  • the cutting motor controls the rotational motion of the cutting sleeve of the device 1002 .
  • the motor is in turn controlled by the motor control module 720 .
  • the vacuum and sample switches of the device 1002 are contact inputs to digital inputs of the control module 102 .
  • the script uses the API as specified in the API module 706 to retrieve the values of these inputs from the control module 102 .
  • the Vacuum LED of the device 1002 is an output of the control module 102 .
  • the script uses the API as specified in the API module 706 to control its state.
  • the driver unit receives its power, control and status information via the control cable 1012 that connects to the medical device connector 308 of the universal control consol 102 .
  • the device 1002 requires a vacuum to remove any excess fluid in the biopsy area and to pull tissue into the biopsy area for subsequent cutting. This vacuum is applied via the vacuum connector 1034 and controlled by the “vacuum” button 1104 or the script software depending on the state of the tool. Controlled RF power or a mechanical cutter may also be necessary for the device 1002 to cut through breast tissue.
  • the RF power is applied through the RF cable connector 1026 and controlled by the footswitch 1014 .
  • the script software can inhibit the footswitch use or turn on the RF power without the footswitch. Whenever a sample of the tissue is desired, the “sample” button 1102 may be pressed to obtain the tissue sample.
  • sterile water or saline line is needed for various surgical operations, and it can be provided through and controlled by the control consol as well.
  • FIG. 10A presents a flowchart 1200 covering the initial script initialization, normal surgical operation states, failure states, and tool exit states of the biopsy driver 1004 in operation with the universal control consol 102 in accordance with one example of the present disclosure.
  • Display screens are generated on the graphical display screen 304 of the universal control consol 102 based on the state of the system.
  • the system may display the status and user action information of the universal control consol 102 and those of the medical device to the operator via various display screens during a surgical operation.
  • the display screens 602 through 616 cover from initial boot-up, medical device connection, utility mode setup, boot-up alarm sequence to the downloading of the medical device script.
  • the specific states in FIG. 10A are unique to the biopsy driver 1004 operating with the universal control consol 102 and are depicted in FIG. 5 as the flow 502 . Any other medical device attached to the universal control consol 102 may have unique states and display screens for their operation.
  • FIGS. 10B to 10 D present various display screens in relation to states in FIG. 10A in accordance with one example of the present disclosure.
  • a script initialization state 1202 may have a display screen that looks like the screen 1204 .
  • initial system parameters, vacuum system parameters, and RF generator parameters are set.
  • This state is initiated after the medical device script is downloaded to the universal control consol. If this initialization is successful, the flow goes to a tool initialization state 1206 , whose display screen may look like the screen 1208 or the screen 1210 , if this is a subsequent initialization due to a reset. If the vacuum initialization fails in the script initialization state, the flow goes to a tool exit state 1212 . If an error occurs, the script will exit to the appropriate error state.
  • tools are initialized without a probe inserted.
  • the tool cycles the stroke motor, by ensuring that it operates at the full stroke and is left in the closed position. On the closing stroke the tool operates the cutting motor, thereby checking for its function.
  • the tool polls the probe's phototransistors to ensure that a tool is not inserted.
  • the tool polls the switches available to the user (“vacuum”, “sample” and “foot switches”) to ensure that none of them is pressed at the end of the cycle of the stroke motor, a situation that may indicate a stuck contact. If a probe is inserted during this state, the software exits to the tool failure state and may display a display screen 1214 . If an error further occurs, the script will exit to the appropriate error state.
  • the calibration state 1216 if the tool initialization state 1206 is successful, the screen 1218 is displayed while waiting for the surgical component such as a probe or a blade to be inserted. Once the probe is inserted, the calibration state 1216 first waits for the “sample” button to be pressed by the operator and then performs two short strokes to calibrate the tool, when the screen 1220 may be displayed. If an error occurs during calibration, such as when the stroke motor is not responding properly or the probe becomes unlatched, the script will exit to a tool failure state 1222 and displays the screen 1224 . If an error further occurs, the script will exit to the appropriate error state.
  • the biopsy area closed state 1226 first waits for the “sample” button to be pressed and then opens the cutter. In state 1226 , the script performs the following functions:
  • screen 1228 wherein the biopsy area is closed and RF is inactive
  • screen 1230 wherein the biopsy area is closed but RF is active
  • screen 1232 wherein the biopsy area is closed and RF is disabled
  • screen 1234 wherein distal trim is enabled
  • screen 1236 wherein the biopsy area is closed, RF is inactive and the footswitch is still pressed from previous RF activation.
  • the state 1226 typically goes to the state 1238 when the “sample” button is pressed.
  • the script performs an open stroke if the distal trim is not enabled and displays the screen 1240 . It is understood that the operator may select a full or half stroke opening of a biopsy cutter, and some necessary GUI may be provided.
  • the open stroke is successfully completed, the flow goes to the biopsy area open state 1242 . If an error occurs during the state 1238 , such as when the stroke motor is not responding properly or probe becomes unlatched, the script will exit to the tool failure state 1222 . If other errors further occur, the script will exit to the appropriate error state.
  • the operator is allowed to activate the vacuum module or ESG module (e.g., if distal trim is not enabled).
  • the flow typically goes to the closing biopsy area state 1244 .
  • the ESG module is disabled if this state is entered from the probe unlatched state PUS, where the probe became unlatched during the close & cut processing of the state 1244 .
  • Some of the possible screens in the state 1242 are: the screen 1246 , which is displayed upon successful completion of the state 1238 , or other states defaulting to the state 1242 even as the state 1242 is not explicitly listed; the screen 1248 , which is displayed after fast-closing processing failed but biopsy area is subsequently opened; the screen 1250 , which is displayed after entering from the state 1238 after the state 1244 and close and cut processing state have failed but biopsy area is subsequently opened; the screen 1252 , which is displayed after entering from the completion of the state 1238 after the timer expired or the stroke motor has stopped during the state 1238 ; the screen 1254 , which is displayed after entering from the state PUS, which is in turn entered from the state 1244 during the close and cut processing state; the screen 1256 , which is displayed when ESG module is active; the screen 1258 , which is displayed when the vacuum module is active; the screen 1260 , which is displayed when entering from the successful completion of the state 1238 , or other entry points not explicitly listed; the screen 1262 ,
  • the vacuum module is activated for two seconds, and then the state 1244 starts the stroke motor to close the cutter and starts the cutting motor. If the “vacuum” button is pressed during the two-second vacuum period, the script will immediately start the stroke motor, at a rate faster than used when cutting, and will not start the cutting motor. When the close stroke is successfully completed, the flow goes to the state 1226 . If an error further occurs, the script will exit to the appropriate error state.
  • Some of the possible screens in the state 1244 are: the screen 1268 , which is displayed during pre-sample vacuum processing; the screen 1270 , which is displayed during fast-closing processing; the screen 1272 , which is displayed during close and cut processing; the screen 1274 , which is displayed during the pause sample processing; and the screen 1276 , which is displayed during distal trim processing. It is further understood that if in any one of the states 1216 , 1222 , 1226 , 1238 , 1242 , 1244 , all these states are routed to state 1212 .
  • FIG. 11A presents a flowchart 1300 covering the unlatched probe processing state of the biopsy driver 1004 in operation with the universal control consol 102 in accordance with one example of the present disclosure.
  • the state PUS is entered from any operational (non-error) state that has a probe inserted in the device.
  • the script prompts the user to reseat the probe as is displayed to the operator as screen 1278 . In most cases, this state exits back to the state the script was in when the error occurred. The exception is if the script was in the state 1244 , in either the pre-sample vacuum or close and cut processing. In those cases, the state PUS exits to the state 1242 , with the ESG module disabled if the error occurred during the close and cut processing.
  • FIG. 11B presents a display screen in relation to the state PUS in FIG. 10A in accordance with one example of the present disclosure.
  • the screen 1304 is displayed when the probe is unlatched, thereby requiring the operator to reseat the probe and reset the device.
  • FIG. 12 presents various display screens in the tool failure state 1222 of the biopsy driver 1004 in operation with the universal control consol 102 in accordance with one example of the present disclosure.
  • the tool failure state is an error state that is entered when an error occurs that requires that the probe to be removed from the device. This state displays a message indicating the error that has occurred and then waits for probe to be removed.
  • Various screens are displayed in the tool failure state: the screen 1402 , when a probe was inserted in the device during the state 1206 ; the screen 1404 , after a biopsy has failed and the subsequent states 1238 also failed; and the screen 1406 , after calibration has failed and open stroke has failed to complete.
  • FIG. 13A presents a flowchart 1500 covering the ESG module failure states (EMFS), whose display screens are further illustrated in FIG. 13B , of the biopsy driver 1004 in operation with the universal control consol 102 in accordance with one example of the present disclosure.
  • EMFS ESG module failure states
  • the state EMFS is entered from any state, except the states 1202 and 1212 , when the system detects a failure in the system.
  • the script supports two types of ESG modules and the detection of a failure depends upon the ESG module type. The absence of any ESG module connected causes an ESG module failure.
  • a Type-C generator is detected, a failure is caused when it does not respond or if the patient pad is not connected when required. (It is required during calibration state and whenever ESG RF is activated.)
  • the following screens are displayed in the ESG module failure state: the screen 1504 , which is displayed when there is a patient pad failure; and the screen 1506 , which is displayed when there is an ESG module failure.
  • FIG. 14A presents a flowchart 1600 covering the vacuum failure states (VFS), whose display screens are further illustrated in FIG. 14B , of the biopsy driver 1004 in operation with the universal control consol 102 in accordance with one example of the present disclosure.
  • VFS vacuum failure states
  • the state VFS is entered from most states when the system detects a failure in the vacuum module.
  • the failure may be a result of the unavailability of the vacuum module (it becomes disconnected) or of a vacuum level that does not meet the minimum requirements.
  • the script will wait for eight seconds to allow the vacuum module to recover, and may turn off the vacuum module and require the operator to press the “reset” button to continue.
  • the following screens are displayed in the vacuum failure state: the screen 1604 , which is displayed while the vacuum is recovering; the screen 1606 , which is displayed after the vacuum is not recovered; and the screen 1608 , which is displayed after vacuum has failed to recover.
  • FIG. 15A presents a flowchart 1700 covering the exit processing states, whose display screens are further illustrated in FIG. 15B , of the biopsy driver 1004 in operation with the universal control consol 102 in accordance with one example of the present disclosure.
  • the tool exit state TES is triggered.
  • the flow goes back to a prior menu screen. If the driver is reconnected, the flow goes to the state 1206 .
  • the following screens are displayed in the tool exit state: the screen 1702 , which is displayed after an integrity check for the ESG module has failed; the screen 1704 , which is displayed after an integrity for the tool has failed; the screen 1706 , which is displayed after the pump fails to initialize; and the screen 1708 , which is displayed after the tool script exits normally.

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US10/847,699 US20050004559A1 (en) 2003-06-03 2004-05-17 Universal medical device control console
EP04753041.5A EP1628580B1 (en) 2003-06-03 2004-05-24 Universal medical device control console
AU2004244989A AU2004244989B2 (en) 2003-06-03 2004-05-24 Universal medical device control console
JP2006514932A JP2007525246A (ja) 2003-06-03 2004-05-24 医療機器のユニバーサルコントロールコンソール
ES04753041T ES2428357T3 (es) 2003-06-03 2004-05-24 Consola de control de dispositivo médico universal
CA2527233A CA2527233C (en) 2003-06-03 2004-05-24 Universal medical device control console
US11/980,956 US8652121B2 (en) 2003-06-03 2007-10-31 Universal medical device control console
US12/220,389 US8696650B2 (en) 2003-06-03 2008-07-24 Universal medical device control console
US12/229,794 US9517104B2 (en) 2000-12-28 2008-08-27 Electrosurgical medical system and method
US12/229,793 US8882760B2 (en) 2000-12-28 2008-08-27 Electrosurgical medical system and method
US14/161,218 US10912541B2 (en) 2003-06-03 2014-01-22 Universal medical device control console
US14/533,684 US10278763B2 (en) 2000-12-28 2014-11-05 Electrosurgical medical system and method

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US11/980,856 Division US8396806B2 (en) 2007-10-30 2007-10-30 End user license agreements associated with messages
US11/980,956 Division US8652121B2 (en) 2003-06-03 2007-10-31 Universal medical device control console
US12/229,794 Continuation-In-Part US9517104B2 (en) 2000-12-28 2008-08-27 Electrosurgical medical system and method
US12/229,793 Continuation-In-Part US8882760B2 (en) 2000-12-28 2008-08-27 Electrosurgical medical system and method

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US12/220,389 Active 2028-05-25 US8696650B2 (en) 2003-06-03 2008-07-24 Universal medical device control console
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US14/161,218 Active 2027-11-17 US10912541B2 (en) 2003-06-03 2014-01-22 Universal medical device control console

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US20140155771A1 (en) 2014-06-05
WO2004107989A1 (en) 2004-12-16
AU2004244989B2 (en) 2011-05-26
EP1628580B1 (en) 2013-07-24
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US10912541B2 (en) 2021-02-09
EP1628580A1 (en) 2006-03-01
US20090030405A1 (en) 2009-01-29
US20100114335A1 (en) 2010-05-06
US8696650B2 (en) 2014-04-15
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CA2527233A1 (en) 2004-12-16
ES2428357T3 (es) 2013-11-07

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