US20040228766A1 - Point of care diagnostic platform - Google Patents

Point of care diagnostic platform Download PDF

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Publication number
US20040228766A1
US20040228766A1 US10/746,127 US74612703A US2004228766A1 US 20040228766 A1 US20040228766 A1 US 20040228766A1 US 74612703 A US74612703 A US 74612703A US 2004228766 A1 US2004228766 A1 US 2004228766A1
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United States
Prior art keywords
cartridge
modules
cartridges
module
sample
Prior art date
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Abandoned
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US10/746,127
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English (en)
Inventor
Thomas Witty
Robert Case
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FasTraQ Inc
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FasTraQ Inc
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Filing date
Publication date
Application filed by FasTraQ Inc filed Critical FasTraQ Inc
Priority to US10/746,127 priority Critical patent/US20040228766A1/en
Assigned to HARTRAQ, INC. reassignment HARTRAQ, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CASE, ROBERT, WITTY, THOMAS R.
Publication of US20040228766A1 publication Critical patent/US20040228766A1/en
Priority to EP04813903A priority patent/EP1702211A2/en
Priority to CN 200480038879 priority patent/CN1898560A/zh
Priority to JP2006547098A priority patent/JP2007516446A/ja
Priority to PCT/US2004/041651 priority patent/WO2005065157A2/en
Priority to CA002549367A priority patent/CA2549367A1/en
Assigned to FASTRAQ, INC. reassignment FASTRAQ, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: HARTRAQ, INC.
Assigned to THE HOWARD C. BIRNDORF LIVING TRUST, FISHER SCIENTIFIC INTERNATIONAL, BRADDOCK FINANCIAL PARTNERS reassignment THE HOWARD C. BIRNDORF LIVING TRUST SECURITY AGREEMENT Assignors: FASTRAQ, INC.
Priority to US11/517,007 priority patent/US20070059204A1/en
Assigned to IN-Q-TEL EMPLOYEE FUND, LLC, IN-Q-TEL, INC. reassignment IN-Q-TEL EMPLOYEE FUND, LLC SECURITY AGREEMENT Assignors: FASTRAQ, INC.
Assigned to BRADDOCK FINANCIAL PARTNERS, LLC, THE HOWARD C. BIRNDORF LIVING TRUST DATED SEPTEMBER 1, 2000 reassignment BRADDOCK FINANCIAL PARTNERS, LLC SECURITY AGREEMENT Assignors: FASTRAQ, INC.
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream

Definitions

  • the present invention relates generally to a point of care diagnostic system that has a plurality of modules and associated cartridges, and more particularly, to a point of care diagnostic system that includes a plurality of modules that share common QC protocols.
  • Blood and other body fluid tests are important diagnostic methods in patient care and treatment. The reliability and the accuracy of the tests are critical in correctly diagnosing the patient and administrating proper treatment.
  • the Food and Drug Administration (FDA) has established numerous quality standards for the various blood or body fluid tests. Monitoring the test process is beneficial in producing reliable and accurate test results.
  • One way of monitoring the test process is periodically performing the monitoring test on standard test samples.
  • the monitoring test results are compared with expected results to verify the accuracy of the test processes or correct the test instrument or process when appropriate.
  • the test processes are assumed to generate consistent result between the monitoring tests.
  • test samples are included in the test process. This approach is suitable for a test process that performs tests on multiple samples. The test results on the standard test samples are compared with expected results to verify the accuracy of the test processes. In this approach, the test processes on real samples are assumed to generate result consistent with those on standard test samples.
  • a point of care diagnostic platform that has a plurality of modules coupled to common host computer.
  • a point of care diagnostic platform with a plurality of modules that share common QC protocols.
  • a point of care diagnostic platform with a plurality of modules coupled to a host computer and an external communication system.
  • a point of care diagnostic platform with a plurality of modules, and a plurality of analytic cartridges where each cartridge is associated with a module and is configured to directly accept a blood sample from a standard blood draw tube.
  • a point of care diagnostic platform that has a plurality of modules, a host computer coupled to the modules, a common external communication interface, with each module sharing the common external communication interface.
  • an object of the present invention is to provide a point of care diagnostic platform that includes a plurality of modules that share common QC protocols. (is the common operator interface another patent?)
  • Another object of the present invention is to provide a point of care diagnostic platform with a plurality of module coupled to a common host computer.
  • Yet another object of the present invention is to provide a point of care diagnostic platform with a plurality of modules, a host computer coupled to the plurality of modules and an external communication system.
  • Still another object of the present invention is to provide a point of care diagnostic platform with a plurality of modules, and a plurality of analytic cartridges, where each cartridge is associated with a module of the plurality of modules and is configured to directly accept a blood sample from a standard blood draw tube.
  • Another object of the present invention is to provide a point of care diagnostic platform with a plurality of modules; a host computer coupled to the plurality of modules and a common external communication interface, with each module sharing the common external communication interface.
  • a further object of the present invention is to provide a point of care diagnostic platform with a plurality of modules coupled to a common external communication interface such as a least one of WAN or a LAN.
  • Another object of the present invention is to provide a point of care diagnostic platform with a plurality of modules coupled to a common external communication interface that is coupled to a wireless network.
  • a further object of the present invention is to provide a point of care diagnostic platform with a plurality of modules coupled to a hospital information network or a laboratory information network.
  • Yet another object of the present invention is to provide a point of care diagnostic platform with a plurality of modules and a plurality of analytic cartridges that are each bar-coded with information for test protocols, and lot expiration dates.
  • Still a further object of the present invention is to provide a point of care diagnostic platform with a plurality of modules and a plurality of analytic cartridges that retain and seal fluids.
  • Yet another object of the present invention is to provide a point of care diagnostic platform that has a plurality of modules and a plurality of analytic cartridges, where all fluids in a cartridge, including a patient sample, remain within the cartridge.
  • a point of care diagnostic platform includes a plurality of modules.
  • a plurality of analytic cartridges are provided. Each cartridge is associated with a module and is configured to directly accept a blood sample from a standard blood draw tube.
  • a point of care diagnostic platform includes a plurality of modules.
  • a host computer is coupled to the plurality of modules and a common external communication interface. Each module shares the common external communication interface.
  • a point of care diagnostic platform includes a plurality of modules each sharing the same QC protocols.
  • a plurality of analytic cartridges are included.
  • a host computer is coupled to the plurality of modules.
  • the host computer is coupled to an interface.
  • Each module has a corresponding interface component.
  • a point of care diagnostic platform includes a plurality of modules.
  • a plurality of analytic cartridges are provided that each are bar-coded with information for test protocols, and lot expiration dates.
  • a point of care diagnostic platform includes a plurality of modules.
  • a plurality of analytic cartridges are provided that retain and seal fluids.
  • a point of care diagnostic platform includes a plurality of modules.
  • a plurality of analytic cartridges are provided. All fluids in the cartridges, including patient samples, remain within the cartridges.
  • a point of care diagnostic platform includes a plurality of modules.
  • a plurality of analytic cartridges are provided. Each cartridge has wet and dry chemistries and at least one substrate that carriers a chemistry.
  • FIG. 1( a ) is a block diagram illustrating one embodiment of a point of care diagnostic platform of the present invention, with a user interface, host computer, multiple single-cartridge test processing modules and an external communication system.
  • FIG. 1( b ) is a block diagram illustrating another embodiment of a point of care diagnostic platform of the present invention, with multiple multi-cartridge test processing modules.
  • FIG. 1( c ) is a block diagram illustrating another embodiment of a point of care diagnostic platform of the present invention, with the host computer being integrated with multiple, multi-cartridge modules.
  • FIG. 1( d ) is a block diagram illustrating another embodiment of a point of care diagnostic platform of the present invention, with the host computer and user interface both integrated with multiple, multi-cartridge modules.
  • FIG. 1( e ) is a block diagram illustrating another embodiment of a point of care diagnostic platform of the present invention, with the host computer and user interface integrated with multiple, single-cartridge modules.
  • FIG. 2 is a cross-sectional view of one embodiment of a cartridge that can be utilized with the point of care diagnostic platform of the present invention.
  • FIG. 3 is a cross-sectional view of a sample tube that can be utilized with cartridges of the present invention.
  • FIG. 4 is a schematic diagram illustrating one embodiment of the docking, and the relationship between a cartridge and a module of the present invention.
  • FIG. 5 is a schematic diagram illustrating another embodiment of the docking, and the relationship between a cartridge and a module of the present invention.
  • FIG. 6 is a schematic diagram illustrating another embodiment of the docking, and the relationship between a cartridge and a module of the present invention.
  • FIG. 7 is a cross-sectional view of one embodiment of a cartridge utilized with the present invention, illustrating air, sample and reagent flow channels.
  • FIG. 8 is a flow chart illustrating an overall methodology of the point of care diagnostic platform of the present invention.
  • FIG. 9 is a flow chart illustrating one embodiment of a cartridge processing procedure implemented with the point of care diagnostic platform of the present invention.
  • FIG. 10 is a flow chart illustrating one embodiment of an immunoassay operating procedure implemented with the point of care diagnostic platform of the present invention.
  • FIG. 11 is a flow chart illustrating one embodiment of a hematology operating procedure implemented with the point of care diagnostic platform of the present invention.
  • Point of care diagnostic platform 10 includes a plurality of modules 12 .
  • modules 12 can be included but not limited to, immunoassay, hematology, electrolyte, molecular diagnostic, coagulation, blood gas, chemistry and the like.
  • the modules 12 can share at least a portion of a common functionality of operation such as fluid movement, sample introduction, and the like.
  • each module 12 contains common functionalities, and unique technologies that correspond to one or more selected chemistries.
  • modules 12 are multiple single-cartridge test processing modules.
  • Platform 10 can deliver a multitude of discreet testing capabilities in a standardized manner.
  • Modules 12 can have common operation platforms. Examples of common operation systems are user interface, quality control, calibration, training, connection to various laboratory information systems, hospital information systems, emergency room information systems, wireless communication and the like.
  • a host computer 14 is coupled to the plurality of modules 12 and also to a user interface 16 .
  • Each module 12 is coupled to the user interface 16 .
  • Host computer 14 has a variety of different capabilities, including but not limited to user interface, quality control, calibration, training, connection to various laboratory information systems, hospital information systems, emergency room information systems, wireless communication and the like.
  • User interface 16 is coupled to each module 12
  • User interface 16 provides uniform (automated and standardized) connectivity to the plurality of modules 12 as well as communication to other hospital and laboratory information systems. It will be appreciated that standardized includes industry standards as documented by the Connectivity Industry Consortium. User interface 16 establishes a database of analyzed samples and provides the operator with quality control options for the plurality of modules 12 .
  • user interface 16 includes capability for at least one of a cardiac, fertility, kidney, coagulation, electrolyte and hematology panel, molecular diagnostics and chemistry panels, and the like.
  • Each module 12 has a corresponding interface component for module control and sample results acquisition.
  • host computer 14 is also coupled to an external communication system 18 .
  • external communication systems are suitable including but not limited to a, WAN, LAN, wireless network, hospital information network, laboratory information network, and the like.
  • Platform 10 can be connected directly or in-directly to a emergency room/department patient management network
  • each module 12 shares common QC protocols.
  • the QC protocols include but are not limited to the following, module electronic verification, real-time process monitoring, patient record-keeping, periodic liquid control results monitoring, and the like.
  • the QC protocols are initiated in the same manner regardless of the module 12 that is tested.
  • Electronic monitoring of the process at each module 12 is continuous and transparent to the operator and do not require operator attention.
  • Results are stored in module specific databases.
  • Each module can utilize specific electronic and/or optical parameter monitoring. Changes in the electronic and optical parameters are tracked during the operation of the module 12 involved, and the outputs compared to expected thresholds/changes. These changes are indicative of correct internal operation during sample processing.
  • FIG. 1( b ) In another embodiment, illustrated in FIG. 1( b ), multiple, multi-modules are provided, where a module 12 can be utilized with more than one cartridge.
  • host computer 14 In FIG. 1( c ) host computer 14 is integrated with multiple, multi-cartridge modules 12 .
  • host computer 14 and user interface 16 are both integrated with multiple, multi-cartridge modules 12 .
  • host computer and user interface 16 are integrated with multiple, single-cartridge test processing modules 12 .
  • Point of care diagnostic platform 10 includes a plurality of cartridges 20 , illustrated in FIG. 2.
  • Cartridges 20 include but are not limited to cardiac, fertility, kidney, coagulation, electrolyte and hematology panel, molecular diagnostics and chemistry panels, and the like.
  • Each cartridge 20 can include a dock 22 for receiving a sample tube, an air dock 24 that can be engaged by a module 12 , a rotary valve 26 , which can also be engaged by a module 12 , a calibration chamber 28 , waste chamber 30 , sample/calibration flow path 32 which is coupled to a detector, sample out flow 34 , sample pressure channel 36 and a flow cell 38 which is a detection chamber.
  • Cartridges 20 can have wet and dry chemistries and at least one substrate that carriers a chemistry. Examples of various wet and dry chemistries are listed in table 1. TABLE 1 cartridge Wet Reagents Dry Reagents electrolytes calibration fluid ion specific electrode immunology — Capture antibody Conjugate antibody hemolotogy Lysing solution/white blood cell — nuclear label Hemoglobin dye Chemistry Various Various Coagulation — Initiator Blood gas — Electrode Molecular Nucleic acid label Nucleic acid capture Amplification reagents
  • Cartridges 20 are associated with a corresponding module 12 .
  • cartridges 20 can directly accept a blood sample from a standard blood draw, sample tube 40 which can include a pressure needle 42 and a sampling needle 44 , as shown in FIG. 3. This can be achieved by, (i) piercing the cap of the standard blood draw tube 40 needles 42 and 44 , which deliver low pressure air to force the sample through the other needle into the cartridge 20 , penetrating the cap with a single needle and withdrawing fluid directly using a vacuum, and the like.
  • Cartridges 20 can be configured to retain and seal fluids.
  • modules 12 can be configured to be engaged with the cartridges 20 to produce pneumatic movement of fluids in the cartridges 20 .
  • the pneumatic pressure is applied by an external pump 46 through the dock 22 on cartridge 20 , FIG. 2, which is engaged by module 12 .
  • Module 12 can include a valve, 48 , a vent 50 to atmosphere and a channel 52 that is coupled to cartridge 20 .
  • the pneumatic pressure is directed to specific reservoirs and samples in cartridge 20 using valve 48 mechanism to cause selective reagent flow.
  • Cartridge 20 includes a sample application area 54 .
  • Optics 56 are included in module 12 and an optical window 57 is included in cartridge 20 .
  • excess pressure is vented through vent 50 to atmosphere to stop the flow.
  • Platform 10 can provide self-testing of modules 12 , to provide for monitoring and detection of fluid flow.
  • Various electrical and optical properties of the samples and reagents allow continuous monitoring of flow cell contents and are compared to expected transition values, as illustrated in FIG. 5.
  • FIG. 6 illustrates a cross-sectional view of one embodiment of a cartridge 20 .
  • Cartridge 20 can have a number of different flow channels, including but not limited to air, sample and reagent flow channels 58 , 60 and 62 .
  • Flow channels 58 - 62 can be created by depressions in both the top and bottom surfaces of the cartridge 20 .
  • Flow paths 58 - 62 can then be sealed with a vapor barrier 64 .
  • pressurization of specific sample or reagent containers provided by pump 46 are selectively directed to sample and reagents containers in sequence, providing an outflow directed by a valve to detection chamber 38 or other location, as needed, in sequence and with precise timing.
  • the sample and reagents can flow through an area of controlled temperature to prepare them for precise analysis prior to or during introduction to detection chamber 38 . After analysis the reagents and sample remain in the cartridge 20 in waste region 30 , although the sample tube 40 can be removed by the operator for subsequent use if desired.
  • Each module 12 can include a processor 56 (FIG. 1( b ).
  • Host computer 16 in combination with a processor 56 , determines a test protocol for a cartridge 20 .
  • a fluid control mechanism in the cartridge 20 is then actuated that permits a flow of a patient sample with liquid chemistries and waste materials. This can occur without exposing an operator of platform 10 and the patient, to a transfer of a patient sample into the cartridge 20 without exposure to the chemistries.
  • Cartridges 20 are designed to isolate biohazards in a cartridge 20 from an operator of the cartridge 20 or the patient. Blood samples from patients are introduced to the cartridges 20 while isolating biohazards in the cartridge from an operator.
  • cartridges 20 are designed to work with whole blood. This eliminates the requirement of a secondary process to remove the cellular components which may interfere with the testing. This additional separation is both time consuming and error prone.
  • the separation of cells is done automatically by providing a barrier which is penetrated by the analyte to be measured by excludes the cells from analytical contact, except in the case of hemotalogy, where the cells themselves are the subject of measurement.
  • Cartridges 20 can include electronic identifiers, including but not limited to bar-coded identifiers, with information for test protocols, and lot expiration dates. Cartridges 20 can also include serialized identification.
  • placement of a cartridge 20 in a module 12 begins an initiation of the module 12 .
  • a cartridge 20 When a cartridge 20 is inserted into a module 12 it can be sensed automatically.
  • the bar code of cartridge 20 with its unique sample, are read. This initiates the sequential operation of the fluid movement and detection.
  • platform 10 includes a plurality of modules 12 each sharing common QC protocols.
  • a list of possible QC protocols is found in table 2.
  • TABLE 2 Responsibility Comments Model POCT Platform Operating Procedure Action (per cartridge) 1.
  • Draw minimum of 1.5 ml whole blood Operator Exact volume sample in appropriate 5 ml vacutainer-type above minimum not draw tube, using standard draw procedure critical 2.
  • Push sample tube into cartridge tube dock Operator and fully seat over needles 3.
  • Place patient ID bar code label in Operator If ED bar code designated target area on tube dock system used 4.
  • LED (blue) above port flashes to indicate Platform No LED, push cartridge fully seated in port and cartridge cartridge further read in process into port 6.
  • FIG. 8 through 11 are flow charts illustrating point of care diagnostic platform 10 of the present invention.
  • FIG. 8 is a flow chart illustrating an overall methodology of the point of care diagnostic platform of the present invention.
  • FIG. 9 is a flow chart illustrating one embodiment of a cartridge processing procedure implemented with the point of care diagnostic platform of the present invention.
  • FIG. 10 is a flow chart illustrating one embodiment of an immunoassay operating procedure implemented with the point of care diagnostic platform of the present invention.
  • FIG. 11 is a flow chart illustrating one embodiment of a hematology operating procedure implemented with the point of care diagnostic platform of the present invention.
  • cartridge 20 contains the fluid flow, fluid distribution fluid segmentation and sample dilution.
  • a module 12 controls the fluid flow via a low pressure air connection and the fluid selection via one or more valve connections.
  • platform 10 provides real time QC monitoring, and real time test result threshold detection, as disclosed in U.S. Provisional No. 60/470,725, incorporated herein by reference.

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
US10/746,127 2003-05-14 2003-12-23 Point of care diagnostic platform Abandoned US20040228766A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US10/746,127 US20040228766A1 (en) 2003-05-14 2003-12-23 Point of care diagnostic platform
CA002549367A CA2549367A1 (en) 2003-12-23 2004-12-13 Point of care diagnostic platform
PCT/US2004/041651 WO2005065157A2 (en) 2003-12-23 2004-12-13 Point of care diagnostic platform
JP2006547098A JP2007516446A (ja) 2003-12-23 2004-12-13 ポイントオブケア診断プラットフォーム
CN 200480038879 CN1898560A (zh) 2003-12-23 2004-12-13 现场即时诊断平台
EP04813903A EP1702211A2 (en) 2003-12-23 2004-12-13 Point of care diagnostic platform
US11/517,007 US20070059204A1 (en) 2003-05-14 2006-09-06 Point of care diagnostic platform

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US47072503P 2003-05-14 2003-05-14
US10/746,127 US20040228766A1 (en) 2003-05-14 2003-12-23 Point of care diagnostic platform

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US10/845,767 Expired - Fee Related US7217393B2 (en) 2003-05-14 2004-05-14 Apparatus and method for process monitoring
US11/064,882 Expired - Fee Related US7189573B2 (en) 2003-05-14 2005-02-23 Apparatus and method for process monitoring
US11/099,707 Expired - Fee Related US7192777B2 (en) 2003-05-14 2005-04-05 Apparatus and method for process monitoring
US11/517,007 Abandoned US20070059204A1 (en) 2003-05-14 2006-09-06 Point of care diagnostic platform

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US11/064,882 Expired - Fee Related US7189573B2 (en) 2003-05-14 2005-02-23 Apparatus and method for process monitoring
US11/099,707 Expired - Fee Related US7192777B2 (en) 2003-05-14 2005-04-05 Apparatus and method for process monitoring
US11/517,007 Abandoned US20070059204A1 (en) 2003-05-14 2006-09-06 Point of care diagnostic platform

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Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080009766A1 (en) * 2005-05-09 2008-01-10 Holmes Elizabeth A Systems and methods for improving medical treatments
US20100100333A1 (en) * 2008-10-15 2010-04-22 Ridge Diagnostics, Inc. Human biomarker hypermapping for depressive disorders
US20100136700A1 (en) * 2008-11-18 2010-06-03 John Bilello Metabolic syndrome and hpa axis biomarkers for major depressive disorder
US20100280562A1 (en) * 2009-04-06 2010-11-04 Ridge Diagnostics, Inc. Biomarkers for monitoring treatment of neuropsychiatric diseases
US7860727B2 (en) 2003-07-17 2010-12-28 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US20110213219A1 (en) * 2010-01-26 2011-09-01 Ridge Diagnostics, Inc. Multiple Biomarker Panels to Stratify Disease Severity and Monitor Treatment of Depression
US8158374B1 (en) 2006-09-05 2012-04-17 Ridge Diagnostics, Inc. Quantitative diagnostic methods using multiple parameters
US8669047B2 (en) 2006-05-10 2014-03-11 Theranos, Inc. Real-time detection of influenza virus
US8697377B2 (en) 2007-10-02 2014-04-15 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US8719053B2 (en) 2003-07-17 2014-05-06 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8778665B2 (en) 2006-11-14 2014-07-15 Theranos, Inc. Detection and quantification of analytes in bodily fluids
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US8862448B2 (en) 2009-10-19 2014-10-14 Theranos, Inc. Integrated health data capture and analysis system
US8883518B2 (en) 2007-08-06 2014-11-11 Theranos, Inc. Systems and methods of fluidic sample processing
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9464981B2 (en) 2011-01-21 2016-10-11 Theranos, Inc. Systems and methods for sample use maximization
US9500663B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Redundant identification for sample tracking on a diagnostic device
CN106483125A (zh) * 2015-08-26 2017-03-08 上海依达医疗器械有限公司 一种智能血瘀诊断仪及其诊断方法
US9592508B2 (en) 2011-09-25 2017-03-14 Theranos, Inc. Systems and methods for fluid handling
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9645143B2 (en) 2011-09-25 2017-05-09 Theranos, Inc. Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US11162936B2 (en) 2011-09-13 2021-11-02 Labrador Diagnostics Llc Systems and methods for multi-analysis
US11215610B2 (en) 2006-10-13 2022-01-04 Labrador Diagnostics Llc Reducing optical interference in a fluidic device
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US11331662B2 (en) 2017-09-29 2022-05-17 Miraplex Diagnostics Inc. Assay preparation device

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060233666A1 (en) * 2005-04-15 2006-10-19 Agamatrix, Inc. Visual display for meter testing bodily fluids
EP1886257A1 (en) 2005-05-11 2008-02-13 Optosecurity Inc. Method and system for screening luggage items, cargo containers or persons
US7991242B2 (en) 2005-05-11 2011-08-02 Optosecurity Inc. Apparatus, method and system for screening receptacles and persons, having image distortion correction functionality
US20070081920A1 (en) * 2005-10-12 2007-04-12 Murphy R S Semi-disposable optoelectronic rapid diagnostic test system
US7899232B2 (en) 2006-05-11 2011-03-01 Optosecurity Inc. Method and apparatus for providing threat image projection (TIP) in a luggage screening system, and luggage screening system implementing same
US8494210B2 (en) 2007-03-30 2013-07-23 Optosecurity Inc. User interface for use in security screening providing image enhancement capabilities and apparatus for implementing same
US20090060783A1 (en) * 2007-09-04 2009-03-05 Kenneth Charles Barrett Polymer concentration monitoring system and use thereof
CN101849186B (zh) * 2007-10-19 2013-05-22 美国中西医疗技术有限责任公司 用于标识和跟踪生物流体的方法和装置
WO2009097364A1 (en) * 2008-01-29 2009-08-06 Pergenix Llc Method and system for delivering clinical lab quality and professional interpretation to home and clinic testing
GB0804764D0 (en) * 2008-03-14 2008-04-16 Cheyney Design & Dev Ltd Test apparatus
US20090285721A1 (en) * 2008-05-15 2009-11-19 Pason Systems Corp. Apparatus for chemical analysis of a sample
US20090305315A1 (en) * 2008-06-09 2009-12-10 Kent Raphael Gandola Hubbed dual cannula device for closed container sampling systems
JP5655091B2 (ja) * 2009-12-18 2015-01-14 エンテグリオン，インコーポレイテッドＥｎｔｅｇｒｉｏｎ，Ｉｎｃ． 携帯式血液凝固モニタリング機器および血液凝固反応の評価方法
US9274042B2 (en) 2010-05-07 2016-03-01 Stc.Unm Spatially correlated light collection from multiple sample streams excited with a line focused light source
US8830451B1 (en) 2010-05-07 2014-09-09 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
US9074977B2 (en) 2010-05-07 2015-07-07 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
CA3069211C (en) 2011-09-07 2022-06-21 Rapiscan Systems, Inc. X-ray inspection system that integrates manifest data with imaging/detection processing
US8986527B2 (en) * 2011-12-06 2015-03-24 Edan Diagnostics Testing cartridge for an in vitro medical diagnostic device
EP2864762A4 (en) * 2012-06-21 2016-01-20 Stc Unm SPATIALLY CORRELATED COLLECTION OF MULTIPLE SAMPLES TREATED WITH A LINE-FOCUSED LIGHT SOURCE
USD717459S1 (en) 2012-11-12 2014-11-11 Edan Diagnostics Diagnostic device
USD706930S1 (en) 2012-11-12 2014-06-10 Edan Diagnostics Fluid cartridge
USD717438S1 (en) 2012-11-12 2014-11-11 Edan Diagnostics Fluid cartridge
CN103543185B (zh) * 2012-12-06 2015-06-24 理邦（美国）诊断有限公司 一种用于体外医疗诊断装置的测试卡
GB2564038B (en) 2016-02-22 2021-11-10 Rapiscan Systems Inc Systems and methods for detecting threats and contraband in cargo
US10349589B2 (en) 2016-09-08 2019-07-16 Hemex Health, Inc. Diagnostics systems and methods
KR102291911B1 (ko) 2016-09-08 2021-08-23 헤멕스 헬스, 인크. 진단 시스템 및 방법
US10648909B2 (en) 2017-05-25 2020-05-12 Abbott Laboratories Methods and systems for assessing flow cell cleanliness
US11740203B2 (en) 2019-06-25 2023-08-29 Hemex Health, Inc. Diagnostics systems and methods

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4222744A (en) * 1978-09-27 1980-09-16 Becton Dickinson & Company Assay for ligands
US5096669A (en) * 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US5965456A (en) * 1992-06-11 1999-10-12 Biacore Ab Analyte detection
US6218719B1 (en) * 1998-09-18 2001-04-17 Capella Microsystems, Inc. Photodetector and device employing the photodetector for converting an optical signal into an electrical signal
US6222619B1 (en) * 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
US6228652B1 (en) * 1999-02-16 2001-05-08 Coulter International Corp. Method and apparatus for analyzing cells in a whole blood sample
US6326612B1 (en) * 1998-10-13 2001-12-04 Texas Instruments Incorporated System and method for optical sensing utilizing a portable, detachable sensor cartridge
US6391541B1 (en) * 1999-05-28 2002-05-21 Kurt E. Petersen Apparatus for analyzing a fluid sample
US6524858B1 (en) * 1999-03-31 2003-02-25 Bayer Corporation Single channel, single dilution detection method for the identification and quantification of blood cells and platelets in a whole blood sample using an automated hematology analyzer
US6592822B1 (en) * 1998-05-14 2003-07-15 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
US6602469B1 (en) * 1998-11-09 2003-08-05 Lifestream Technologies, Inc. Health monitoring and diagnostic device and network-based health assessment and medical records maintenance system
US6611634B2 (en) * 1996-03-19 2003-08-26 University Of Utah Research Foundation Lens and associatable flow cell
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0690211B2 (ja) * 1984-09-21 1994-11-14 オリンパス光学工業株式会社 免疫学的分析装置およびその方法
EP0273934B1 (en) * 1986-07-01 1990-09-05 Biotech Instruments Limited Apparatus for automatic chemical analysis
EP0504772A3 (en) * 1991-03-18 1993-01-27 Paradigm Biotechnologies Partnership Analytical apparatus
EP0725593B1 (en) * 1993-10-28 2004-04-07 I-Stat Corporation Fluid sample collection and introduction device
JP2973887B2 (ja) * 1995-08-31 1999-11-08 株式会社島津製作所 核酸分子の分析方法及び装置
US5902982A (en) * 1997-04-04 1999-05-11 National Medical Review Office Inc. Changeable machine readable assaying indicia
US6002475A (en) * 1998-01-28 1999-12-14 Careside, Inc. Spectrophotometric analytical cartridge
JP3304878B2 (ja) * 1998-04-30 2002-07-22 三菱マテリアル株式会社 流れ分析法によるハロゲン濃度の測定方法と装置
EP1047929B1 (en) * 1998-11-13 2007-07-04 Reichert, Inc. Method for qualitative and quantitative measurements
DE60041255D1 (de) * 1999-04-28 2009-02-12 Eidgenoess Tech Hochschule Polyionische beschichtungen für analytische und sensor-vorrichtungen
CA2314398A1 (en) * 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
JP2002148181A (ja) * 2000-11-07 2002-05-22 Hioki Ee Corp フローインジェクション分析装置
KR100426210B1 (ko) * 2000-11-11 2004-04-03 피티플러스(주) 실리콘 박막 결정화 방법

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4222744A (en) * 1978-09-27 1980-09-16 Becton Dickinson & Company Assay for ligands
US5096669A (en) * 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US5965456A (en) * 1992-06-11 1999-10-12 Biacore Ab Analyte detection
US6611634B2 (en) * 1996-03-19 2003-08-26 University Of Utah Research Foundation Lens and associatable flow cell
US6222619B1 (en) * 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
US6592822B1 (en) * 1998-05-14 2003-07-15 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US6218719B1 (en) * 1998-09-18 2001-04-17 Capella Microsystems, Inc. Photodetector and device employing the photodetector for converting an optical signal into an electrical signal
US6326612B1 (en) * 1998-10-13 2001-12-04 Texas Instruments Incorporated System and method for optical sensing utilizing a portable, detachable sensor cartridge
US6602469B1 (en) * 1998-11-09 2003-08-05 Lifestream Technologies, Inc. Health monitoring and diagnostic device and network-based health assessment and medical records maintenance system
US6228652B1 (en) * 1999-02-16 2001-05-08 Coulter International Corp. Method and apparatus for analyzing cells in a whole blood sample
US6524858B1 (en) * 1999-03-31 2003-02-25 Bayer Corporation Single channel, single dilution detection method for the identification and quantification of blood cells and platelets in a whole blood sample using an automated hematology analyzer
US6391541B1 (en) * 1999-05-28 2002-05-21 Kurt E. Petersen Apparatus for analyzing a fluid sample

Cited By (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7860727B2 (en) 2003-07-17 2010-12-28 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US8812329B2 (en) 2003-07-17 2014-08-19 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US8719053B2 (en) 2003-07-17 2014-05-06 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
JP2019219416A (ja) * 2005-05-09 2019-12-26 セラノス アイピー カンパニー エルエルシー ポイントオブケア流体システムおよびその使用
JP2021193390A (ja) * 2005-05-09 2021-12-23 ラブラドール ダイアグノスティクス エルエルシー ポイントオブケア流体システムおよびその使用
EP3763824A1 (en) * 2005-05-09 2021-01-13 Labrador Diagnostics LLC Point-of-care fluidic systems and uses thereof
US9182388B2 (en) 2005-05-09 2015-11-10 Theranos, Inc. Calibration of fluidic devices
US9075046B2 (en) 2005-05-09 2015-07-07 Theranos, Inc. Fluidic medical devices and uses thereof
US20080009766A1 (en) * 2005-05-09 2008-01-10 Holmes Elizabeth A Systems and methods for improving medical treatments
US10761030B2 (en) 2005-05-09 2020-09-01 Labrador Diagnostics Llc System and methods for analyte detection
US8679407B2 (en) * 2005-05-09 2014-03-25 Theranos, Inc. Systems and methods for improving medical treatments
JP2015158506A (ja) * 2005-05-09 2015-09-03 セラノス， インコーポレイテッド ポイントオブケア流体システムおよびその使用
US9772291B2 (en) 2005-05-09 2017-09-26 Theranos, Inc. Fluidic medical devices and uses thereof
US10908093B2 (en) 2005-05-09 2021-02-02 Labrador Diagnostics, LLC Calibration of fluidic devices
JP2015158507A (ja) * 2005-05-09 2015-09-03 セラノス， インコーポレイテッド ポイントオブケア流体システムおよびその使用
JP2017142265A (ja) * 2005-05-09 2017-08-17 セラノス， インコーポレイテッド ポイントオブケア流体システムおよびその使用
US11630069B2 (en) 2005-05-09 2023-04-18 Labrador Diagnostics Llc Fluidic medical devices and uses thereof
US8841076B2 (en) 2005-05-09 2014-09-23 Theranos, Inc. Systems and methods for conducting animal studies
EP1883341B1 (en) 2005-05-09 2020-08-12 Labrador Diagnostics LLC Point-of-care fluidic systems and uses thereof
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US10533994B2 (en) 2006-03-24 2020-01-14 Theranos Ip Company, Llc Systems and methods of sample processing and fluid control in a fluidic system
US9176126B2 (en) 2006-03-24 2015-11-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8669047B2 (en) 2006-05-10 2014-03-11 Theranos, Inc. Real-time detection of influenza virus
US9885715B2 (en) 2006-05-10 2018-02-06 Theranos IP Comany, LLC Real-time detection of influenza virus
US11162947B2 (en) 2006-05-10 2021-11-02 Labrador Diagnostics Llc Real-time detection of influenza virus
US8158374B1 (en) 2006-09-05 2012-04-17 Ridge Diagnostics, Inc. Quantitative diagnostic methods using multiple parameters
US8450077B2 (en) 2006-09-05 2013-05-28 Ridge Diagnostics, Inc. Quantitative diagnostic methods using multiple parameters
US11215610B2 (en) 2006-10-13 2022-01-04 Labrador Diagnostics Llc Reducing optical interference in a fluidic device
US11442061B2 (en) 2006-10-13 2022-09-13 Labrador Diagnostics Llc Reducing optical interference in a fluidic device
US10156579B2 (en) 2006-11-14 2018-12-18 Theranos Ip Company, Llc Methods for the detection of analytes in small-volume blood samples
US8778665B2 (en) 2006-11-14 2014-07-15 Theranos, Inc. Detection and quantification of analytes in bodily fluids
US9303286B2 (en) * 2006-11-14 2016-04-05 Theranos, Inc. Detection and quantification of analytes in bodily fluids
US11802882B2 (en) 2006-11-14 2023-10-31 Labrador Diagnostics Llc Methods for the detection of analytes in small-volume blood samples
US9575058B2 (en) 2007-08-06 2017-02-21 Theranos, Inc. Systems and methods of fluidic sample processing
US8883518B2 (en) 2007-08-06 2014-11-11 Theranos, Inc. Systems and methods of fluidic sample processing
US11754554B2 (en) 2007-08-06 2023-09-12 Labrador Diagnostics Llc Systems and methods of fluidic sample processing
US10900958B2 (en) 2007-10-02 2021-01-26 Labrador Diagnostics Llc Modular point-of-care devices, systems, and uses thereof
US9285366B2 (en) 2007-10-02 2016-03-15 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US11899010B2 (en) 2007-10-02 2024-02-13 Labrador Diagnostics Llc Modular point-of-care devices, systems, and uses thereof
US9121851B2 (en) 2007-10-02 2015-09-01 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US9581588B2 (en) 2007-10-02 2017-02-28 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US9588109B2 (en) 2007-10-02 2017-03-07 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US11137391B2 (en) 2007-10-02 2021-10-05 Labrador Diagnostics Llc Modular point-of-care devices, systems, and uses thereof
US11199538B2 (en) 2007-10-02 2021-12-14 Labrador Diagnostics Llc Modular point-of-care devices, systems, and uses thereof
US10670588B2 (en) 2007-10-02 2020-06-02 Theranos Ip Company, Llc Modular point-of-care devices, systems, and uses thereof
US10634667B2 (en) 2007-10-02 2020-04-28 Theranos Ip Company, Llc Modular point-of-care devices, systems, and uses thereof
US9012163B2 (en) 2007-10-02 2015-04-21 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US11366106B2 (en) 2007-10-02 2022-06-21 Labrador Diagnostics Llc Modular point-of-care devices, systems, and uses thereof
US11092593B2 (en) 2007-10-02 2021-08-17 Labrador Diagnostics Llc Modular point-of-care devices, systems, and uses thereof
US11061022B2 (en) 2007-10-02 2021-07-13 Labrador Diagnostics Llc Modular point-of-care devices, systems, and uses thereof
US8697377B2 (en) 2007-10-02 2014-04-15 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US9435793B2 (en) 2007-10-02 2016-09-06 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US11143647B2 (en) 2007-10-02 2021-10-12 Labrador Diagnostics, LLC Modular point-of-care devices, systems, and uses thereof
US8822167B2 (en) 2007-10-02 2014-09-02 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
US20100100333A1 (en) * 2008-10-15 2010-04-22 Ridge Diagnostics, Inc. Human biomarker hypermapping for depressive disorders
US8440418B2 (en) 2008-11-18 2013-05-14 Ridge Diagnostics, Inc. Metabolic syndrome and HPA axis biomarkers for major depressive disorder
US20100136700A1 (en) * 2008-11-18 2010-06-03 John Bilello Metabolic syndrome and hpa axis biomarkers for major depressive disorder
US20100280562A1 (en) * 2009-04-06 2010-11-04 Ridge Diagnostics, Inc. Biomarkers for monitoring treatment of neuropsychiatric diseases
US11158429B2 (en) 2009-10-19 2021-10-26 Labrador Diagnostics Llc Integrated health data capture and analysis system
US11195624B2 (en) 2009-10-19 2021-12-07 Labrador Diagnostics Llc Integrated health data capture and analysis system
US11139084B2 (en) 2009-10-19 2021-10-05 Labrador Diagnostics Llc Integrated health data capture and analysis system
US8862448B2 (en) 2009-10-19 2014-10-14 Theranos, Inc. Integrated health data capture and analysis system
US9460263B2 (en) 2009-10-19 2016-10-04 Theranos, Inc. Integrated health data capture and analysis system
US20110213219A1 (en) * 2010-01-26 2011-09-01 Ridge Diagnostics, Inc. Multiple Biomarker Panels to Stratify Disease Severity and Monitor Treatment of Depression
US11199489B2 (en) 2011-01-20 2021-12-14 Labrador Diagnostics Llc Systems and methods for sample use maximization
US9464981B2 (en) 2011-01-21 2016-10-11 Theranos, Inc. Systems and methods for sample use maximization
US9677993B2 (en) 2011-01-21 2017-06-13 Theranos, Inc. Systems and methods for sample use maximization
US10557786B2 (en) 2011-01-21 2020-02-11 Theranos Ip Company, Llc Systems and methods for sample use maximization
US10876956B2 (en) 2011-01-21 2020-12-29 Labrador Diagnostics Llc Systems and methods for sample use maximization
US11644410B2 (en) 2011-01-21 2023-05-09 Labrador Diagnostics Llc Systems and methods for sample use maximization
US11162936B2 (en) 2011-09-13 2021-11-02 Labrador Diagnostics Llc Systems and methods for multi-analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US10627418B2 (en) 2011-09-25 2020-04-21 Theranos Ip Company, Llc Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US10557863B2 (en) 2011-09-25 2020-02-11 Theranos Ip Company, Llc Systems and methods for multi-analysis
US10976330B2 (en) 2011-09-25 2021-04-13 Labrador Diagnostics Llc Fluid handling apparatus and configurations
US11009516B2 (en) 2011-09-25 2021-05-18 Labrador Diagnostics Llc Systems and methods for multi-analysis
US11054432B2 (en) 2011-09-25 2021-07-06 Labrador Diagnostics Llc Systems and methods for multi-purpose analysis
US10534009B2 (en) 2011-09-25 2020-01-14 Theranos Ip Company, Llc Systems and methods for multi-analysis
US9128015B2 (en) 2011-09-25 2015-09-08 Theranos, Inc. Centrifuge configurations
US10518265B2 (en) 2011-09-25 2019-12-31 Theranos Ip Company, Llc Systems and methods for fluid handling
US9592508B2 (en) 2011-09-25 2017-03-14 Theranos, Inc. Systems and methods for fluid handling
US10371710B2 (en) 2011-09-25 2019-08-06 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10018643B2 (en) 2011-09-25 2018-07-10 Theranos Ip Company, Llc Systems and methods for multi-analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US11524299B2 (en) 2011-09-25 2022-12-13 Labrador Diagnostics Llc Systems and methods for fluid handling
US9952240B2 (en) 2011-09-25 2018-04-24 Theranos Ip Company, Llc Systems and methods for multi-analysis
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9719990B2 (en) 2011-09-25 2017-08-01 Theranos, Inc. Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9645143B2 (en) 2011-09-25 2017-05-09 Theranos, Inc. Systems and methods for multi-analysis
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9500663B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Redundant identification for sample tracking on a diagnostic device
CN106483125A (zh) * 2015-08-26 2017-03-08 上海依达医疗器械有限公司 一种智能血瘀诊断仪及其诊断方法
US11331662B2 (en) 2017-09-29 2022-05-17 Miraplex Diagnostics Inc. Assay preparation device

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US20050186681A1 (en) 2005-08-25
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WO2004104552A3 (en) 2005-04-28
US20050186682A1 (en) 2005-08-25
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US7192777B2 (en) 2007-03-20
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US7217393B2 (en) 2007-05-15
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