US20040185027A1 - Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent - Google Patents
Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent Download PDFInfo
- Publication number
- US20040185027A1 US20040185027A1 US10/783,721 US78372104A US2004185027A1 US 20040185027 A1 US20040185027 A1 US 20040185027A1 US 78372104 A US78372104 A US 78372104A US 2004185027 A1 US2004185027 A1 US 2004185027A1
- Authority
- US
- United States
- Prior art keywords
- composition
- agent
- tooth
- phosphate
- monoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- compositions useful in dentifrices and other oral care products relate to compositions useful in dentifrices and other oral care products.
- the invention relates to oral care compositions containing a surfactant agent consisting essentially of water soluble salts of monoalkyl and dialkyl phosphate esters, wherein the molar ratio of monoesters to diesters is greater than 1.
- U.S. Pat. No. 4,152,421 refers to the use of alkali metal or alkanolamine salts of alkyl phosphate esters in dentifrice formulations, citing the high foaming property of the high monoalkyl content phosphate esters (monoalkyl:dialkyl phosphate, or MAP:DAP, weight ratio of 70:30-100:0) as novel, in combination with the “known” property of having no substantial after effects on the tastes and flavors of foods and drinks, especially citrus juices.
- the concept and range of structures is expanded in a subsequent patent, U.S. Pat. No.
- 4,350,680 is reduction in the sloughing or desquamation of oral mucosa during tooth brushing action if at least 0.2% of an anionic phosphate ester surface active agent is used as an additional surfactant to sodium lauryl sulfate.
- U.S. Pat. No. 5,019,373 attempted to improve upon these patents by claiming special advantages for the incorporation of shorter alkyl chain (C 6 to C 9 ) dialkyl phosphate esters, particularly dioctyl phosphate. The phosphate ester concentration was rather high, at 2-4 wt. %, in the dentifrice formulation.
- the remineralization process may stop before the lesion is completely and uniformly remineralized, or “repaired”.
- the rapid remineralization results in a build up of remineralized material on the tooth surface, which then prevents diffusion of the ions into the deeper regions of the lesion, resulting in a void or structure weakening fault in the calcium hydroxyapatite mineral crystal lattice.
- JP 05-320032 disclosed that dentifrices (mouthwash) containing monoalkyl enriched phosphate ester salt mixtures (e.g. MAP:DAP 90:10 w/w), calcium scavengers (e.g. sodium tripolyphosphate), phenol derivatives and, optionally, water soluble fluorides, formed a film on the surface of the teeth to prevent dental plaque formation and improve acid resistance.
- monoalkyl enriched phosphate ester salt mixtures e.g. MAP:DAP 90:10 w/w
- calcium scavengers e.g. sodium tripolyphosphate
- phenol derivatives e.g. sodium tripolyphosphate
- water soluble fluorides e.g. sodium tripolyphosphate
- the preferred phosphate ester was identified as MAP-20H, manufactured by Kao Corporation (Rhodia counterpart, DERMALCARE® MAP-L-200). Rapid and continued disinfectant action against oral bacteria was also taught for oral care products containing anti-bacterial quaternary ammonium salts of phosphate esters, optionally in combination with the arginine salts, for a pleasant taste in U.S. Pat. No. 5,374,418. It should also be noted that oral care compositions containing phosphate esters and cationic antibacterial agents had been reported decades earlier in GB Patent No. 1,475,251.
- the vesicles contain calcium binding lipids and alkaline phosphatase.”“Since these vesicles only appear at the beginning of the hard tissue formation, it is apparent that there must also be other mechanisms which lead to the mineralization of a tissue. In fact, the extra-cellular matrix contains quite a few organic molecules which may act as nucleators . . . These molecules include, for example, osteonectin, phosphoproteins, collagen, anionic phospholipids and sulphur containing compounds such as chondroitin sulfate and ceratan sulfate.”
- U.S. Pat. No. 6,416,745 also emphasizes blocking or plugging up the tubules as the best way to effectively correct hypersensitivity.
- the patent expands upon the concept by using liposomes (tiny balloons whose walls are lipid bi-layers) to deposit in the tubules and induce mineral [apatite] formation by acting as a mineral template that attracts soluble mineral ions that are naturally present in the dentin tubular fluid and saliva. “These liposome-surface-attracted soluble mineral ions precipitate from the dentin tubule fluid onto the liposome surface, which in turn, acts to nucleate mineral growth in the fluid.
- the mineral formed in the dentinal tubules will provide a massive, insoluble plug, thereby restoring the tubules to their healthy, naturally impermeable state, blocking tubule fluid movement and insulating the dentinal nerves.”
- Liposomes with a choline [amphoteric, e.g. lecithin] or inositol [nonionic, e.g. sugar] surface are not mineral-inducing.
- Liposomes derived from salts of di(oleoyl)phosphatidic acid (DOPA) are preferred (and the only example given).
- the coating would crack or lift up at its edges, allowing fluids containing bacteria, especially the Streptococcus mutans , to penetrate into these narrow fissures, where they could then flourish in a relatively protected area where tooth brush bristles could not dislodge them.
- it is not good oral hygiene practice to cut off the tooth surfaces from the active action of the saliva because it contains enzymes, minerals and other beneficial ingredients, calcium and phosphate ions, for instance, which promote slow, natural remineralization of the enamel and dentin surfaces at points of damage, within reason. (The caries develop because the acids released in the metabolism of sucrose by the S.
- Temporary coatings might be helpful as an effective tooth protective system, however, if they could be conveniently applied by the individual (not requiring a visit to the dental office) and would penetrate effectively into the areas between the teeth, below the gum line and into the fissures (for instance in the top surfaces of molars). They should last from about a half-day to a week and leave no residue behind that would build up or disrupt the natural hydroxyapatite mineral structure. Accordingly, there is a need in the art for improved oral care formulations.
- This invention relates to an oral care composition for reducing hypersensitivity in teeth comprising a surfactant agent consisting essentially of water soluble monoalkyl and dialkyl phosphate esters, wherein the ratio of monoesters to diesters is greater than 1.
- the invention may also include an abrasive agent consisting essentially of siliceous materials, particularly silica.
- the invention further relates to the use of a water soluble, monoalkyl enriched, dodecyl phosphate ester salt surfactant in a dentifrice, particularly a standard toothpaste. It has been discovered that water soluble phosphate ester salts, particularly monoalkyl enriched dodecyl phosphate ester salts, are an effective agent in preventing the pain associated with tooth hypersensitivity.
- the invention also relate to a tooth cleaning product comprising a surfactant agent consisting essentially of water soluble salts of monoalkyl and dialkyl phosphate esters, wherein the molar ratio of monoalkyl esters to dialkyl esters is greater than 1, an abrasive agent and optionally a liquid.
- a surfactant agent consisting essentially of water soluble salts of monoalkyl and dialkyl phosphate esters, wherein the molar ratio of monoalkyl esters to dialkyl esters is greater than 1, an abrasive agent and optionally a liquid.
- a tooth powder comprising:
- the invention provides amouthwash comprising:
- the invention also provides an oral care composition having anti-sensitivity effect upon teeth which contains an essential anti-sensitivity agent which essentially comprises an effective amount of a water soluble mixture of monoalkyl and dialkyl phosphate ester salts.
- Yet another object of the invention is an oral care composition
- an oral care composition comprising an effective amount of a water soluble alkali metal or a functional amine salt of a phosphate ester, effective to reduce sensitivity in teeth.
- Still yet another object of the invention is to provide an oral care compositon comprising an effective amount of salts of monoalkyl or monoalkenyl phosphates of Structure (I) and water soluble salts of dialkyl or dialkenyl phosphates of Structure (II):
- R1, R2 and R3 are from 8 to 22 carbon atoms; n and m are 2 to 4; a and b are 0 to 20; one of Z1 or Z2 is selected from the group consisting of an alkali metal, an ammonium, protonated alkyl amine, protonated alkanolamine or a protonated basic amino acid; and the other of Z1 or Z2 is selected from the group consisting of hydrogen, an alkali metal, an ammonium, protonated alkyl amine, protonated alkanolamine, or a protoanted basic amino acid; and Z3 is selected from a group consisting of an alkali metal, an ammonium, protonated alkyl amine or protonated alkanolamine, or a protonated basic amino acid.
- a temporary, ablatable coating on tooth surfaces would rinse away any S. mutans that had attached to it. This would serve as an anti-plaque agent by preventing the accumulation of the bacteria and their by-products that form plaque. It may be less necessary to use biocides to kill these bacteria because they would not be able to establish the large colonies on the tooth surfaces to produce acid in sufficient, localized concentration to cause problems. This would preserve the beneficial bacteria.
- the ablatable, organic coating or film also would provide a protective shield against staining agents (tobacco, tea, etc.) and carry away any which would have adsorbed onto it.
- the coating should serve an anti-calculus function by carrying away the preliminary mineral deposits on it, if any, before they could build up excessively to form calculus or tartar.
- This approach would be superior to the seemingly vain search for a more permanent coating with the requisite toughness and durability, which would, on one hand, adhere to tooth structure but, on the other, be so slick that nothing would stick to it.
- the water soluble salts of simple, alkyl or alkyl ethoxylate phosphate esters would be uniquely suited to the above concept. They have been shown to adhere to and form a hydrophobic coating on calcium salts, tooth enamel and dentin.
- the advantage over the related alkylphosphonic acids would be that the alkyl phosphate linkage would be hydrolyzed, catalyzed by the phosphatase enzymes in the oral environment, and the hydrophobic, fatty alkyl group would be released from the surface, hence they would function as an ablatable coating with the above stated advantages. This would provide an additional benefit because the now simple, inorganic phosphate group remaining behind, deposited on the tooth, would presumably be retained in its place.
- an amount of soluble monoalkyl and dialkyl phosphate ester salts that is “effective to reduce tooth sensitivity” means an amount of the phosphate ester salt that provides improved reduction of tooth sensitivity or hypersensitivity, as measured by, for example, clinical tests, as compared to a directly analogous dentifrice or oral hygiene product that does not contain soluble monoalkyl and dialkyl phosphate ester salts in accordance with the invention.
- oral care composition is used to designate products which, in the ordinary course of usage, are retained in the oral cavity for a time sufficient to contact substantially all of the dental surfaces, such as dentifrices, gels, mouthwashes, chewing gums and lozenges, but are not intentionally ingested.
- Water soluble salts of monoalkyl phosphate esters useful for the invention include salts monoalkyl or monoalkenyl phosphates of Structure (I) and water soluble salts of dialkyl phosphate esters include salts of dialkyl or dialkenyl phosphates of Structure (II):
- R1, R2 and R3 are, individually, linear or branched, saturated or unsaturated hydrocarbons of from 8 to 22 carbon atoms, n and m are, individually and separately, 2 to 4, and a and b, individually and separately, are 0 to 20.
- Z1 or Z2 is an alkali metal, an ammonium, protonated alkyl amine or protonated functional alkyl amine such as an alkanolamine, including those described in U.S. patent application Ser. No.
- 10/161,057 and/or a basic amino acid and the other is hydrogen, an alkali metal, an ammonium, protonated alkyl amine or protonated functional alkyl amine such as an alkanolamine, including those described in U.S. patent application Ser. No. 10/161,057 and/or a basic amino acid.
- Z3 is an alkali metal, an ammonium, protonated alkyl amine or protonated functional alkyl amine such as an alkanolamine, including those described in U.S. patent application Ser. No. 10/161,057 and/or a basic amino acid.
- a composition in accordance with the invention comprises a water soluble monoalkyl and dialkyl phosphate ester salt as the active ingredient or anti-sensitivity agent of an oral hygiene agent.
- Monoalkyl enriched phosphate esters based on a single alcohol or blend of alcohols, linear or branched, saturated or unsaturated, of from 8 to 22 carbon atoms and degrees of ethoxylation from 0-20, should be effective as anti-sensitivity agents.
- the C-10 to C-14, 0-4 EO phosphates would be preferred.
- For formation of a protective coating which retards deposition of S. mutans longer carbon chain and, optionally, poly(oxyethylene) chain lengths would be useful.
- the hydrophobe and poly(oxyethylene) chains could be adjusted widely, within the range, to provide phosphate ester components to serve other purposes, such as enhancement of the deposition and retention of actives on the tooth surface, for example, flavor or biocidal ingredients, without significantly interfering with the anti-sensitivity action of the composition.
- the water soluble monoalkyl and dialkyl phosphate ester salts have a molar ratio of monoesters to diesters of at least 1.
- the water soluble monoalkyl and dialkyl phosphate ester salt compositions will have molar ratios of the monoalkyl to dialkyl of 70:30, preferably 80:20, and most preferably, 85:15 to 100:00 would be most useful.
- Any suitable water soluble monalkyl dialkyl phosphate salt may be used, particularly water soluble alkali metal or functional amine salts of phosphate esters.
- Suitable alkali metal salts include, but are not limited to lithium, sodium and potassium and suitable functional amine salts include, but are not limited to, trialkanolamines and basic amino acids.
- Other useful water soluble monoalkyl and dialkyl phosphate ester salts are those described in U.S. patent application Ser. No. 10/161,057, which is herein incorporated by reference.
- a preferred water soluble monoalkyl and dialkyl phosphate ester salt is potassium dodecyl phosphate.
- the potassium dodecyl phosphate is preferably a monoalkyl enriched surfactant.
- One particularly useful monoalkyl enriched potassium dodecyl phosphate is commercially available from Rhodia Inc. and sold under the tradename MAP-L-200/K (powder form) or MAP-L-204/K (42% aqueous solution form) in the DERMALCARE® product line.
- an oral hygiene composition in accordance with the invention may comprise without intended limitation components customarily used in this field, such as a polishing agent (abrasive agent), sudsing agents, a binder, a humectant, a medicinal agent, a sweetening agent, a flavor and water.
- a polishing agent abrasive agent
- sudsing agents a binder
- a humectant a medicinal agent
- sweetening agent a flavor and water.
- abrasive agents consisting essentially of siliceous materials, e.g. silica
- suitable abrasive agents consisting essentially of siliceous materials, e.g. silica
- other functional additives that may be useful in the compositions of this invention are disclosed in the U.S. Pat. Nos. 6,416,745 and 6,464,963, the disclosures of which are incorporated herein by reference.
- Compatible and desirable abrasive agent systems may include, hydrated silica, colloidal silica, fumed silica, insoluble sodium metaphosphate, insoluble sodium aluminosilicates, sodium bicarbonate or mixtures thereof.
- the abrasive agent system may be present in an amount up to 70% by weight, preferably 5 to 70% by weight, more preferably from 10 to 60% by weight.
- abrasive agents are dictated by compatibility with the herein described soluble alkyl phosphate ester salts. It will be obvious to one skilled in the art that calcium based abrasive systems, such as calcium pyrophosphate, dibasic calcium phosphates, and calcium carbonate will not be suitable for this invention due to adsorption of the soluble alkyl phosphate ester salts.
- calcium based abrasive systems such as calcium pyrophosphate, dibasic calcium phosphates, and calcium carbonate will not be suitable for this invention due to adsorption of the soluble alkyl phosphate ester salts.
- silica is a preferred abrasive, particularly in conjunction with a potassium dodecyl phosphate, because it retains the excellent foaming characteristics.
- a first toothpaste formulation was based on dicalcium phosphate dihydrate as the abrasive.
- the foam volume and quality were found to be inadequate, presumably because of the strong interaction of the potassium dodecyl phosphate (1.2%) with the dicalcium phosphate dihydrate (48.8%).
- This affinity for and deposition of the potassium dodecyl phosphate onto dicalcium phosphate dihydrate was also observed in earlier experiments in which the ester was evaluated as a method to modify the surface of the particles.
- the dicalcium phosphate dihydrate particles were notably more hydrophobic after treatment with a solution of the potassium dodecyl phosphate.
- Humectants contemplated for use in a composition of the invention include polyols, such as glycerol, sorbitol, polyethylene glycols, propylene glycol, hydrogenated partially hydrolyzed polysaccharides and the like. Exemplary amounts are provided below with reference to various types of compositions.
- binders suitable for use in a composition of the invention include hydroxyethyl cellulose, and hydroxypropyl cellulose, as well as xanthan gums, Iris moss and gum tragacanth. Binders may be present in the amount from 0.01 to 10%. Sweeteners suitable for use, e.g. saccharin, may be present at levels of about 0.1% to 5%.
- Anti-caries agents may also be used in conjunction with the oral anti-sensitivity agent in accordance with the invention.
- oral hygiene compositions in accordance with the invention may include those commonly used in oral health care compositions, such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride and cobalt ammonium fluoride and the like.
- Preferred compositions in accordance with the present invention will include a fluoride source. Fluoride ions are typically provided at a level up to 1500 ppm, preferably 50 to 1500 ppm, although higher levels up to about 3000 ppm may be used as well.
- compositions in accordance with the present invention may also include antibacterial agents.
- Suitable antibacterial agents include, phenolics and salicylamides.
- Such antibacterial agents in addition to other functional agents, including therapeutic agents and nutrients, may be incorporated into the liposomes themselves in accordance with the present invention.
- Dyes/colorants suitable for oral health care compositions i.e. FD & C Blue #1, FD & C Yellow #10, FD & C Red #40, etc.
- Various other optional ingredients may also be included in the compositions of the invention such as preservatives; vitamins, for example, vitamins C and E; and other anti-plaque agents, for example, stannous salts, copper salts, strontium salts and magnesium salts.
- Compositions may also include anti-calculus agents such as a water-soluble alkali metal salt of a polyphosphate, buffering agents such as alkali metal orthophosphates, phosphoric acid, alkali metal glycerophosphates, tartrates, or citrates, other anti-caries agents, for example, calcium glycerophosphate, sodium trimetaphosphate; anti-staining compounds, for example silicone polymers; plant extracts; and mixtures thereof.
- polymers, particularly anionic polymers, such as polycarboxylates or polysulfonates, or polymers containing both a carboxylate and a sulfonate moiety, phosphonate polymers or polyphosphates may be used.
- a toothpaste or gel in accordance with the invention will generally comprise a surfactant agent consisting essentially of water soluble salts of monoalkyl and dialkyl phosphate esters, wherein the molar ratio of monoesters to diesters is greater than 1, a compatible abrasive agent system, and a liquid in an amount to provide the desired consistency.
- a surfactant agent consisting essentially of water soluble salts of monoalkyl and dialkyl phosphate esters, wherein the molar ratio of monoesters to diesters is greater than 1, a compatible abrasive agent system, and a liquid in an amount to provide the desired consistency.
- the liquid may include water, humectant and binder, generally, in an amount ranging from about 10 to about 90% by weight of the toothpaste.
- Water is a desirable component when a toothpaste or gel is being prepared. Water comprises up to about 50%, and preferably about 5-35% by weight of the toothpaste.
- an anhydrous toothpaste or gel can be formulated if desired.
- a humectant is also a desirable component in a toothpaste or gel.
- the humectant comprises about 5% to about 85% by weight of the formulation, and preferably from about 10% to about 70% by weight of the formulation.
- the refractive index is an important consideration, it is preferred to use higher ratios of humectant to water than in opaque pastes.
- the ratio of humectant to water should preferably be above about 0.5 to 1, and more preferably above 1 to 1.
- a tooth powder in accordance with the invention may comprise a polishing agent which is compatible with the soluble monoalkyl and dialkyl phosphate ester salts described herein, such as sodium bicarbonate or hydrated silica.
- the polishing agent will be in an amount from about 20 to about 95%,and preferably above 50% by weight of the formulation.
- An effective amount of the monoalkyl and dialkyl phosphate esters as described herein is typically from about 0.1 to about 10% and preferably about 1% to about 5% by weight of the tooth powder formulation.
- components which may be included in the toothpowder are a flavoring agent and/or sweetening agent, an anti-calculus agent such as a water-soluble alkali metal salt of a polyphosphate, an anti-caries agent such as sodium fluoride or sodium monofluorophosphate, buffering agents such as alkali metal orthophosphates, phosphoric acid, alkali metal glycerophosphates, tartrates, or citrates, and one or more processing aids such as a flow aid to insure product uniformity.
- an anti-calculus agent such as a water-soluble alkali metal salt of a polyphosphate
- an anti-caries agent such as sodium fluoride or sodium monofluorophosphate
- buffering agents such as alkali metal orthophosphates, phosphoric acid, alkali metal glycerophosphates, tartrates, or citrates
- processing aids such as a flow aid to insure product uniformity.
- a mouthwash in accordance with the invention generally comprises alcohol, water, humectant, and an effective amount of the monoalkyl and dialkyl phosphate ester salts as described herein.
- An effective amount of the monoalkyl and dialkyl phosphate ester salts in the mouthwash is typically from about 0.1% to about 10% and preferably from about 1% to about 5% by weight of the mouthwash.
- components which are included in the mouthwash are a flavoring agent and/or sweetening agent, an anti-calculus agent such as a water-soluble alkali metal salt of a polyphosphate, an anti-caries agent such as sodium fluoride or sodium monofluorophosphate, buffering agents such as alkali metal orthophosphates, phosphoric acid, alkali metal glycerophosphates, tartrates, or citrates.
- an anti-calculus agent such as a water-soluble alkali metal salt of a polyphosphate
- an anti-caries agent such as sodium fluoride or sodium monofluorophosphate
- buffering agents such as alkali metal orthophosphates, phosphoric acid, alkali metal glycerophosphates, tartrates, or citrates.
- the water soluble monalkyl and dialkyl phosphate ester salt of the invention may be prepared by any suitable method.
- the potassium dodecyl phosphate, MAP-L-200/K was prepared by methods described in U.S. Pat. Nos. 5,550,274; 5,554,781; 6,136,221; and 6,262,130, the disclosures of which are incorporated herein by reference.
- a 42% aqueous solution, of for example, DERMALCARE® MAP-L-204/K may be spray dried by standard techniques at 200° C.
- the 31 P and 13 C NMR spectra indicate that the spray drying process has little effect upon the composition except that the residual phosphoric acid is partially converted to pyrophosphoric acid (potassium salt) and the residual dodecanol is removed.
- a composition containing the soluble phosphate ester salt anti-sensitivity agent for example a soluble phosphate ester salt anti-sensitivity agent containing toothpaste
- other oral care products such as mouth wash, chewing gum, soluble oral care strips (similar to the LISTERINE® oral care strips) and even lozenges, all of which would beneficially contain the soluble phosphate ester salt anti-sensitivity agent and, optionally, an appropriate ethoxylate agent (e.g. the hexadecyl-8 EO ethoxylate) for replenishment of the S. mutans repelling coating between brushings.
- an appropriate ethoxylate agent e.g. the hexadecyl-8 EO ethoxylate
- phosphate esters and linear fatty alcohols on which they are preferably based are natural and safe for ingestion in the minor amounts incidental to their use in oral care products.
- Dental hypersensitivity generally results from exposure of the tubules in dentin to oral fluids and temperature changes. As the general population ages and the individual's teeth become worn from frequent brushing, gums recede or pockets develop from poor oral hygiene habits. The problem of dental hypersensitivity is increasing as-evidenced by the number of brands of anti-sensitivity toothpastes on the store shelves has quadrupled in the past five years. Currently, the most common treatment is to use a toothpaste containing 5% potassium nitrate. The potassium and nitrate ions diffuse into the tubules to desensitize the nerves, hence reducing the pain, but do not correct the source of the problem.
- the soluble salts of simple phosphate esters are well adapted to resolve this problem. Since the water soluble phosphate ester salts typically are very effective surfactants (low surface tension and critical micelle concentration) and cleansing agents (proven for skin and claimed in dentifrice formulations), they would effectively penetrate deeply into the tiniest crevices and tubules, where the phosphate head group would anchor to the calcium hydroxyapatite tooth structure. The hydrophobic tail of the water soluble salts would provide temporary relief by partially blocking the tubule and reducing the rate of fluid exchange, which contributes to the irritation. As the phosphate ester link is hydrolyzed, the phosphate head group would remain on the tooth, where it is subsequently fixed in place by reaction with calcium in the saliva as the fatty alcohol “tail” is washed away.
- the longer term use of the phosphate ester-based toothpaste has demonstrated an unexpectedly long lasting, beneficial therapeutic effect.
- the sensitivity normally would return within two to three weeks after they were discontinued, consistent with the action of the potassium nitrate as a temporary, nerve desensitizing agent.
- continuing freedom from pain associated with the hypersensitivity condition was experienced for fifteen months after the completion of the evaluation period for a toothpaste in accordance with the invention. This long term relief can be explained by and is evidence of the “healing” mineralization process that presumably occurred in the tubules over the twenty-one week period of use.
- phosphates as the principal detergent surfactant in the toothpaste is the result of its very low irritancy potential and tissue compatibility. It has been reported to substantially reduce the stripping of oral mucosa through sloughing or desquamation compared to sodium lauryl sulfate, the most commonly used toothpaste surfactant.
- the detersive and foaming properties of the comparable monoalkyl phosphate ester, potassium lauryl phosphate has been shown in lab and skin cleanser tests to be at least equivalent to the sodium lauryl sulfate.
- Related to the harshness of the sodium lauryl sulfate is the retardation of the healing process of canker sores and other oral mucosa lesions.
- phosphate esters particularly monoalkyl phosphate esters, have been shown to have the lowest skin irritation potential of any anionic (or cationic) surfactant. In the absence of such daily irritation, it is reasonable to expect that such lesions would not become so painfully large and would heal more quickly.
- phosphate esters to tissues, especially skin, has been utilized to increase the deposition of active ingredients onto and into them.
- active ingredients methyl salicylate, menthol and camphor
- phosphate esters In toothpaste applications, enhanced uptake and retention of antibacterial agents, such as Triclosan, onto dental “tissue” (teeth) has been reported. It stands to reason, then, that phosphate esters would deposit other organic therapeutic, flavor or fragrant “freshening” ingredients in the oral cavity for a longer acting, more effective therapeutic activity or feeling of freshness and cleanness.
- the stability to oxidation would provide yet another benefit.
- the phosphate esters of simple, linear aliphatic alcohols contain no “active”, covalently bound hydrogens, which would be subject to peroxide oxidation.
- the peroxides used in tooth whitening formulations would not be decomposed by them and the film they form on the tooth would retain a higher concentration of the peroxide (especially, but not limited to, basic oxidants such as urea or carbamide peroxides) in contact with the tooth surface for a longer period of time (hours), until the phosphatase harmlessly hydrolyzes the ester link and the film and the peroxide oxidation product residues are washed cleanly and completely away.
- the remineralization process promoted by the phosphate group left behind on the dental surface may serve to partially compensate for the damage to the tooth structure potentially caused by the action of the peroxide.
- the advantages of the oral hygiene compositions of the invention include: providing an ablatable coating for anti-adherence of stain and bacteria to teeth; desensitization of teeth having dentinal hypersensitivity; low irritancy and improved tissue compatibility or tolerance; increased deposition of various ingredients, including anti-microbials, flavor oils; compatibility with peroxide whitening agents; and anti-tartar characteristics.
- the following non-limiting examples are given.
- the subject began the test period using a test formulation.
- the test formulation was prepared using potassium dodecyl phosphate, MAP-L-200/K, which is commercially available from Rhodia Inc. in the DERMALCARE® phosphate ester line.
- the test formulation was prepared by methods described in the examples below.
- a 42% aqueous solution, DERMALCARE® MAP-L-204/K, (from Examples 1 and 2) was spray dried by standard techniques at 200° C. in a pilot plant unit.
- the 31 P and 13 C NMR spectra indicated that the spray drying process had little effect upon the composition except that the residual phosphoric acid was partially converted to pyrophosphoric acid (potassium salt) and the residual dodecanol was removed.
- the subject used the test formulation in his daily, morning tooth brushing regimen with a soft bristle brush provided by his dentist, with use of no additional oral care products except for dental floss.
- the brushing procedure was to squeeze about 4 g of the paste over the top of the moistened brush bristles, then spread the paste uniformly over the tooth surfaces with a circular brushing motion.
- the buccal and lingual surfaces were then brushed with a vertical motion, away from the gums, and the molar crowns were brushed with a side-to-side motion. The excess foam was expelled.
- the coating effect seemed to last for about a “working day” (8-12 hours). Overnight, especially, the typical film of oral “refuse” tended to accumulate on the teeth, particularly at the gum line. This film was easily removed by brushing the next morning.
- the protection afforded by the phosphate ester protective film could be achieved or prolonged by use of a mouth wash, soluble oral care strip, chewing gum or lozenge, all of which would beneficially contain the water soluble phosphate ester salt and, optionally, an appropriate nonionic surfactant (e.g. hexadecyl-8 EO ethoxylate).
- the potassium dodecyl phosphate, MAP-L-200/K was prepared by methods described in U.S. Pat. Nos. 5,550,274; 5,554,781; 6,136,221; and 6,262,130, the disclosures of which are incorporated herein by reference.
- the 42% aqueous solution, DERMALCARE® MAP-L-204/K was spray dried by standard techniques at 200° C. in a pilot plant unit.
- the 31 P and 13 C NMR spectra indicated that the spray drying process had little effect upon the composition except that the residual phosphoric acid was partially converted to pyrophosphoric acid (potassium salt) and the residual dodecanol was removed.
- a typical calcium based abrasive tooth paste formulation was prepared using dibasic calcium phosphate, dihydrate as the abrasive and conventional mixing techniques as shown below. Upon dilution of this formulation (3:1, w/v) the foam volume and quality were found to be significantly reduced in comparison to a silica abrasive based formulation. This finding was in contrast to an earlier patent discussed above (U.S. Pat. No. 4,152,421) and was presumably so because of the strong interaction of the potassium dodecyl phosphate (1.2%) with the calcium phosphate abrasive.
- CMC 7MXF carboxymethylcellulose
- Four weeks is the estimated time from manufacture to delivery to store shelf, before the consumer would be able to purchase the product.
- the second criterion is fluoride compatibility.
- the industry standard is that the level of total soluble fluoride in a silica based toothpaste must not drop by more than 10% over a twelve week storage period at 40.6° C.
- Table 2 summarizes the changes in viscosity of the three formulations over a twelve week period of storage at 23.9° and 40.6° C. All were within the required limits at four and twelve weeks. TABLE 2 Viscosity Stability Study of Tooth Paste Formulations Ave. Viscosity (BKU), Ave. Vis. (BKU), Tooth Paste Stability Test Formulations 23.9 C. Storage @ 40.6 C. Storage @ NB Ref.
- Table 3 shows the changes in soluble fluoride concentration of the three formulations over the twelve week storage at 40.60° and a shorter, three week storage at 49° C. In this series also, the 40.60° storage resulted in only a small change in the soluble fluoride concentration. Again, all formulations passed.
- the MAP formulations therefore do not cause or undergo any transformations which significantly affect either the viscosity or soluble fluoride concentration and are entirely suitable as a replacement for sodium lauryl sulfate in toothpaste formulations.
- This formulation is meant to describe but not limit the invention.
- the total formulation in which the monoalkyl phosphate ester could be used, as well as the specific phosphate ester(s) which may be chosen would depend upon the product.
- the various ingredients and proportions would be similar to those described in the references cited, incorporated herein by reference, and known to those skilled in the art as long as they did not significantly impair the anti-hypersensitivity performance of the soluble phosphate ester salt.
- the concentration of the phosphate ester salt would preferably range from 0.1-50 wt. %, or more and the specific phosphate ester salt composition would be selected, again, depending upon the method of application and the desired result.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/783,721 US20040185027A1 (en) | 2003-02-21 | 2004-02-20 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
US12/319,856 US9034308B2 (en) | 2003-02-21 | 2009-01-13 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque ultra-mild oral hygiene agent |
US12/380,971 US9040025B2 (en) | 2003-02-21 | 2009-03-05 | Anti-senstivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44912803P | 2003-02-21 | 2003-02-21 | |
US10/783,721 US20040185027A1 (en) | 2003-02-21 | 2004-02-20 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/319,856 Continuation US9034308B2 (en) | 2003-02-21 | 2009-01-13 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque ultra-mild oral hygiene agent |
US12/380,971 Continuation US9040025B2 (en) | 2003-02-21 | 2009-03-05 | Anti-senstivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040185027A1 true US20040185027A1 (en) | 2004-09-23 |
Family
ID=32927496
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/783,721 Abandoned US20040185027A1 (en) | 2003-02-21 | 2004-02-20 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
US12/319,856 Active 2025-10-28 US9034308B2 (en) | 2003-02-21 | 2009-01-13 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque ultra-mild oral hygiene agent |
US12/380,971 Active 2024-10-25 US9040025B2 (en) | 2003-02-21 | 2009-03-05 | Anti-senstivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/319,856 Active 2025-10-28 US9034308B2 (en) | 2003-02-21 | 2009-01-13 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque ultra-mild oral hygiene agent |
US12/380,971 Active 2024-10-25 US9040025B2 (en) | 2003-02-21 | 2009-03-05 | Anti-senstivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
Country Status (10)
Country | Link |
---|---|
US (3) | US20040185027A1 (fr) |
EP (2) | EP2281550A3 (fr) |
JP (1) | JP2006518744A (fr) |
KR (1) | KR20050105230A (fr) |
CN (1) | CN1750807B (fr) |
BR (1) | BRPI0407746A (fr) |
CA (1) | CA2516950C (fr) |
MX (1) | MXPA05008302A (fr) |
RU (1) | RU2337734C2 (fr) |
WO (1) | WO2004075770A2 (fr) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060142174A1 (en) * | 2003-04-14 | 2006-06-29 | Kao Corporation | Cleaning agent composition |
US20080159966A1 (en) * | 2005-02-04 | 2008-07-03 | Rupesh Kumar Agarwal | Multiphase Toothpaste Composition |
US20080187498A1 (en) * | 2005-02-04 | 2008-08-07 | Edward Francis | Multiphase Toothpaste Composition |
US20080187497A1 (en) * | 2005-02-04 | 2008-08-07 | Rupesh Kumar Agarwal | Toothpaste |
US20080247973A1 (en) * | 1999-11-12 | 2008-10-09 | Arif Ali Baig | Compositions and Methods for Improving Overall Tooth Health and Appearance |
WO2008154617A2 (fr) | 2007-06-12 | 2008-12-18 | Rhodia Inc. | Composition de nettoyage pour surface dure avec agent d'hydrophilisation et procédé pour nettoyer des surfaces dures |
US20090123407A1 (en) * | 2007-06-12 | 2009-05-14 | Rhodia Inc. | Mono-, di- and polyol phosphate esters in personal care formulations |
US20090123393A1 (en) * | 2005-02-04 | 2009-05-14 | Nand Sanmukhdas Bijlani | Multiphase Toothpaste Composition |
US20090202455A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
US20090238775A1 (en) * | 2007-06-12 | 2009-09-24 | Rhodia Inc. | Mono-, di- and polyol alkoxylate phosphate esters in oral care formulations and methods for using same |
US20100316579A1 (en) * | 2006-10-26 | 2010-12-16 | Glaxo Group Limited | Novel use of alkyl phosphate esters |
US7919449B2 (en) | 2007-06-12 | 2011-04-05 | Rhodia Operations | Detergent composition with hydrophilizing soil-release agent and methods for using same |
US20110085990A1 (en) * | 2008-02-08 | 2011-04-14 | Colgate-Palmolive Company | Oral care methods and systems |
US20110089073A1 (en) * | 2009-09-11 | 2011-04-21 | The Procter & Gamble Company | Methods And Compositions For Hydrophobic Modification Of Oral Cavity Surfaces |
US20120020897A1 (en) * | 2009-04-02 | 2012-01-26 | Colgate-Palmolive Company | Dentifrice composition |
US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
US8993506B2 (en) | 2006-06-12 | 2015-03-31 | Rhodia Operations | Hydrophilized substrate and method for hydrophilizing a hydrophobic surface of a substrate |
US20160312013A1 (en) * | 2013-12-05 | 2016-10-27 | Colgate-Palmolive Company | Method of measuring viscosity of gums |
US20180289599A1 (en) * | 2015-10-08 | 2018-10-11 | Colgate-Palmolive Company | Oral Care Compositions |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0512478A (pt) | 2004-07-02 | 2008-03-11 | Discus Dental Impressions Inc | composição de tratamento de fluoreto de prescrição |
CN101095656B (zh) * | 2007-07-19 | 2010-11-03 | 法国医药集团 | 穿心莲在制备牙齿清洁用品中的应用及其牙齿清洁用品 |
US8523475B2 (en) * | 2009-12-23 | 2013-09-03 | Colgate-Palmolive Company | Oral care system, kit and method |
AU2010333783B2 (en) | 2009-12-23 | 2014-01-30 | Colgate-Palmolive Company | Oral care system |
US9358185B2 (en) | 2012-06-18 | 2016-06-07 | 3M Innovative Properties Company | Powder composition for air polishing the surface of hard dental tissue |
EP2742898A1 (fr) | 2012-12-17 | 2014-06-18 | 3M Innovative Properties Company | Dispositif à jet de poudre pour diffusion de matériau dentaire |
EP2742897A1 (fr) | 2012-12-17 | 2014-06-18 | 3M Innovative Properties Company | Buse, pièce à main et dispositif à jet de poudre pour appliquer un matériau dentaire |
US9662180B2 (en) | 2012-12-17 | 2017-05-30 | 3M Innovative Properties Company | Device for dispensing a dental material with locking mechanism |
US9801916B2 (en) * | 2013-02-07 | 2017-10-31 | Tomás Bernardo Galvan Gonzalez | Oral antiseptic composition useful for treating oral mucositis |
CN104248516B (zh) * | 2014-08-11 | 2017-06-06 | 秦俊远 | 一种不含过氧化物的牙齿美白贴膜的制备方法 |
CN106999407B (zh) * | 2014-11-13 | 2020-11-17 | 罗地亚经营管理公司 | 用于牙齿表面的消融性的、可更新的、多功能保护涂层 |
US9993408B2 (en) | 2015-09-17 | 2018-06-12 | Johnson & Johnson Consumer Inc. | Compositions comprising zwitterionic alkyl-alkanoylamides and/or alkyl alkanoates |
KR101956579B1 (ko) | 2018-05-09 | 2019-03-11 | 주식회사 하이센스바이오 | 상아질 지각과민증 완화를 위한 치약 조성물 |
KR101956578B1 (ko) | 2018-05-09 | 2019-03-11 | 주식회사 하이센스바이오 | 상아질 지각과민증 완화를 위한 구강 청결용 조성물 |
AU2019403912B2 (en) | 2018-12-20 | 2022-09-29 | Colgate-Palmolive Company | Dentifrice containing sodium bicarbonate and stannous fluoride |
EP3979980A4 (fr) * | 2019-06-05 | 2023-08-02 | Rhodia Operations | Composition de soins buccaux |
Citations (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036950A (en) * | 1975-01-15 | 1977-07-19 | Colgate-Palmolive Company | Oral preparations |
US4083955A (en) * | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
US4152421A (en) * | 1976-10-12 | 1979-05-01 | Kao Soap Co., Ltd. | Dentifice composition |
US4264580A (en) * | 1979-04-23 | 1981-04-28 | Barberio Giacinto G | Dental cream composition |
US4350680A (en) * | 1980-09-24 | 1982-09-21 | Colgate-Palmolive Company | Dentifrice |
US4397676A (en) * | 1982-03-08 | 1983-08-09 | Geshuri Laboratories Ltd. | N-Phosphonomethylglycine derivatives |
US4522805A (en) * | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
US5019373A (en) * | 1988-12-01 | 1991-05-28 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Oral composition |
US5180579A (en) * | 1988-12-01 | 1993-01-19 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Topical composition comprising a mixture of particular di-alkyl or alkenyl phosphate esters and mono-alkyl or alkenyl phosphate esters |
US5244651A (en) * | 1991-09-04 | 1993-09-14 | Kao Corporation | Method of desensitizing hypersensitive dentin |
US5370865A (en) * | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
US5374418A (en) * | 1992-02-13 | 1994-12-20 | Kao Corporation | Composition for use in oral cavity |
US5550274A (en) * | 1994-03-30 | 1996-08-27 | Reierson; Robert L. | In-situ phosphation reagent process |
US5554781A (en) * | 1994-03-30 | 1996-09-10 | Reierson; Robert L. | Monoalkyl phosphonic acid ester production process |
US5603922A (en) * | 1995-08-08 | 1997-02-18 | Enamelon Inc. | Processes and compositions for the remineralization of teeth |
US5605676A (en) * | 1995-06-26 | 1997-02-25 | Colgate-Palmolive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
US5605675A (en) * | 1995-06-06 | 1997-02-25 | Enamelon Inc. | Processes and compositions for remineralization and prevention of demineralization of dental enamel |
US5628429A (en) * | 1995-11-22 | 1997-05-13 | Enamelon, Inc. | Plural chambered squeezable dispensing tube |
US5891233A (en) * | 1994-10-06 | 1999-04-06 | Bioxid Oy | Use of bioactive silicious glass and new compositions containing bioactive silicious glass |
US6110445A (en) * | 1995-06-26 | 2000-08-29 | Colgate-Palmotive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
US6262130B1 (en) * | 1998-11-24 | 2001-07-17 | Rhodia, Inc. | High solids, pumpable aqueous compositions of high monoalkyl phosphate ester salt content |
US6416745B1 (en) * | 2001-05-03 | 2002-07-09 | Block Drug Company, Inc. | Dental composition for treating hypersensitive teeth |
US6464963B1 (en) * | 1998-04-23 | 2002-10-15 | Colgate Palmolive Company | Desensitizing dentifrice containing potassium and tin salts |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1408922A (en) | 1972-02-02 | 1975-10-08 | Blendax Werke Schneider Co | Process and composition for the remineralisation and prevention of demineralisation of human teeth |
NO158361C (no) * | 1981-07-03 | 1988-08-31 | Intradal Nv | Tannpleiemiddel med antikaries-virkning. |
US4971782A (en) * | 1983-09-14 | 1990-11-20 | Peroxydent Group | Periodontal composition and method |
GB8527962D0 (en) * | 1985-11-13 | 1985-12-18 | Neirinckx R D | Desensitizing dental composition |
JPH05320032A (ja) | 1992-05-20 | 1993-12-03 | Kao Corp | 口腔用組成物 |
US5292502A (en) * | 1992-07-02 | 1994-03-08 | Colgate-Palmolive Co. | Non-irritating dentifrice |
JPH0692860A (ja) * | 1992-09-14 | 1994-04-05 | Kao Corp | 知覚過敏症治療剤 |
JPH0813251B2 (ja) | 1993-07-14 | 1996-02-14 | 長岡香料株式会社 | 鉄及び又はマグネシウム及び又はカルシウムを含む呈味改善液 |
US6713049B1 (en) * | 1999-11-12 | 2004-03-30 | The Procter & Gamble Company | Oral compositions providing optimal surface conditioning |
JP3793621B2 (ja) | 1997-04-25 | 2006-07-05 | 花王株式会社 | 知覚過敏用口腔用組成物 |
US7387774B2 (en) * | 1999-11-12 | 2008-06-17 | The Procter & Gamble Co. | Method of enhancing fluoridation and mineralization of teeth |
US9139731B2 (en) * | 1999-11-12 | 2015-09-22 | The Procter & Gamble Company | Compositions and methods for improving overall tooth health and appearance |
US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
US20040146466A1 (en) * | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
US6926916B1 (en) * | 1999-11-12 | 2005-08-09 | The Procter & Gamble Company | Chewing gum compositions |
US20020041852A1 (en) * | 2000-08-18 | 2002-04-11 | Napolitano Neil J. | Dental composition for hypersensitive teeth |
AR030713A1 (es) * | 2000-08-21 | 2003-09-03 | Block Drug Co | Composicion dental para reducir la hipersensibilidad dentinal debida a la presencia de superficie dentinal expuesta y de tubulos dentinales abiertos, uso de una combinacion sinergica de una cantidad desensibilizadora de al menos un agente de bloqueo de los tubulos y un agente desensibilizador del ne |
ATE341391T1 (de) | 2001-06-04 | 2006-10-15 | Rhodia | Pumpfähige, flüssige, grenzflächenaktive mittel enthaltende zusammensetzungen, umfassend alkanolaminsalze von alkylphosphatestern |
GB0621329D0 (en) | 2006-10-26 | 2006-12-06 | Glaxo Group Ltd | Novel composition |
-
2004
- 2004-02-20 US US10/783,721 patent/US20040185027A1/en not_active Abandoned
- 2004-02-20 CN CN2004800045789A patent/CN1750807B/zh not_active Expired - Fee Related
- 2004-02-20 BR BRPI0407746-6A patent/BRPI0407746A/pt not_active IP Right Cessation
- 2004-02-20 EP EP10172254A patent/EP2281550A3/fr not_active Withdrawn
- 2004-02-20 MX MXPA05008302A patent/MXPA05008302A/es unknown
- 2004-02-20 JP JP2006503730A patent/JP2006518744A/ja active Pending
- 2004-02-20 EP EP04713361A patent/EP1599182A4/fr not_active Ceased
- 2004-02-20 CA CA2516950A patent/CA2516950C/fr not_active Expired - Lifetime
- 2004-02-20 RU RU2005129336/15A patent/RU2337734C2/ru not_active IP Right Cessation
- 2004-02-20 WO PCT/US2004/005004 patent/WO2004075770A2/fr active Application Filing
- 2004-02-20 KR KR1020057015384A patent/KR20050105230A/ko not_active Application Discontinuation
-
2009
- 2009-01-13 US US12/319,856 patent/US9034308B2/en active Active
- 2009-03-05 US US12/380,971 patent/US9040025B2/en active Active
Patent Citations (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036950A (en) * | 1975-01-15 | 1977-07-19 | Colgate-Palmolive Company | Oral preparations |
US4083955A (en) * | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
US4152421A (en) * | 1976-10-12 | 1979-05-01 | Kao Soap Co., Ltd. | Dentifice composition |
US4264580A (en) * | 1979-04-23 | 1981-04-28 | Barberio Giacinto G | Dental cream composition |
US4350680A (en) * | 1980-09-24 | 1982-09-21 | Colgate-Palmolive Company | Dentifrice |
US4397676A (en) * | 1982-03-08 | 1983-08-09 | Geshuri Laboratories Ltd. | N-Phosphonomethylglycine derivatives |
US4522805A (en) * | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
US5019373A (en) * | 1988-12-01 | 1991-05-28 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Oral composition |
US5180579A (en) * | 1988-12-01 | 1993-01-19 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Topical composition comprising a mixture of particular di-alkyl or alkenyl phosphate esters and mono-alkyl or alkenyl phosphate esters |
US5244651A (en) * | 1991-09-04 | 1993-09-14 | Kao Corporation | Method of desensitizing hypersensitive dentin |
US5374418A (en) * | 1992-02-13 | 1994-12-20 | Kao Corporation | Composition for use in oral cavity |
US5370865A (en) * | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
US5550274A (en) * | 1994-03-30 | 1996-08-27 | Reierson; Robert L. | In-situ phosphation reagent process |
US5554781A (en) * | 1994-03-30 | 1996-09-10 | Reierson; Robert L. | Monoalkyl phosphonic acid ester production process |
US6136221A (en) * | 1994-03-30 | 2000-10-24 | Rhodia Inc. | Phosphation reagent |
US5891233A (en) * | 1994-10-06 | 1999-04-06 | Bioxid Oy | Use of bioactive silicious glass and new compositions containing bioactive silicious glass |
US5605675A (en) * | 1995-06-06 | 1997-02-25 | Enamelon Inc. | Processes and compositions for remineralization and prevention of demineralization of dental enamel |
US5605676A (en) * | 1995-06-26 | 1997-02-25 | Colgate-Palmolive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
US6110445A (en) * | 1995-06-26 | 2000-08-29 | Colgate-Palmotive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
US5603922A (en) * | 1995-08-08 | 1997-02-18 | Enamelon Inc. | Processes and compositions for the remineralization of teeth |
US5628429A (en) * | 1995-11-22 | 1997-05-13 | Enamelon, Inc. | Plural chambered squeezable dispensing tube |
US6464963B1 (en) * | 1998-04-23 | 2002-10-15 | Colgate Palmolive Company | Desensitizing dentifrice containing potassium and tin salts |
US6262130B1 (en) * | 1998-11-24 | 2001-07-17 | Rhodia, Inc. | High solids, pumpable aqueous compositions of high monoalkyl phosphate ester salt content |
US6416745B1 (en) * | 2001-05-03 | 2002-07-09 | Block Drug Company, Inc. | Dental composition for treating hypersensitive teeth |
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080247973A1 (en) * | 1999-11-12 | 2008-10-09 | Arif Ali Baig | Compositions and Methods for Improving Overall Tooth Health and Appearance |
US9161895B1 (en) | 1999-11-12 | 2015-10-20 | The Procter & Gamble Company | Compositions and methods for improving overall tooth health and appearance |
US9139731B2 (en) | 1999-11-12 | 2015-09-22 | The Procter & Gamble Company | Compositions and methods for improving overall tooth health and appearance |
US20060142174A1 (en) * | 2003-04-14 | 2006-06-29 | Kao Corporation | Cleaning agent composition |
US20080159966A1 (en) * | 2005-02-04 | 2008-07-03 | Rupesh Kumar Agarwal | Multiphase Toothpaste Composition |
US20080187498A1 (en) * | 2005-02-04 | 2008-08-07 | Edward Francis | Multiphase Toothpaste Composition |
US20080187497A1 (en) * | 2005-02-04 | 2008-08-07 | Rupesh Kumar Agarwal | Toothpaste |
US20090123393A1 (en) * | 2005-02-04 | 2009-05-14 | Nand Sanmukhdas Bijlani | Multiphase Toothpaste Composition |
US8993506B2 (en) | 2006-06-12 | 2015-03-31 | Rhodia Operations | Hydrophilized substrate and method for hydrophilizing a hydrophobic surface of a substrate |
US20100316579A1 (en) * | 2006-10-26 | 2010-12-16 | Glaxo Group Limited | Novel use of alkyl phosphate esters |
US7919449B2 (en) | 2007-06-12 | 2011-04-05 | Rhodia Operations | Detergent composition with hydrophilizing soil-release agent and methods for using same |
WO2008154617A2 (fr) | 2007-06-12 | 2008-12-18 | Rhodia Inc. | Composition de nettoyage pour surface dure avec agent d'hydrophilisation et procédé pour nettoyer des surfaces dures |
US20110064687A1 (en) * | 2007-06-12 | 2011-03-17 | Rhodia Inc. | Mono-, di- and polyol phosphate esters in personal care formulations |
US7919073B2 (en) * | 2007-06-12 | 2011-04-05 | Rhodia Operations | Mono-, di- and polyol alkoxylate phosphate esters in oral care formulations and methods for using same |
US20090238775A1 (en) * | 2007-06-12 | 2009-09-24 | Rhodia Inc. | Mono-, di- and polyol alkoxylate phosphate esters in oral care formulations and methods for using same |
US20090123407A1 (en) * | 2007-06-12 | 2009-05-14 | Rhodia Inc. | Mono-, di- and polyol phosphate esters in personal care formulations |
US7867963B2 (en) * | 2007-06-12 | 2011-01-11 | Rhodia Inc. | Mono-, di- and polyol phosphate esters in personal care formulations |
AU2008266168B2 (en) * | 2007-06-12 | 2014-07-10 | Rhodia Inc. | Mono-di-and polyol phosphate esters in personal care formulations |
US8268765B2 (en) * | 2007-06-12 | 2012-09-18 | Rhodia Operations | Mono-, di- and polyol phosphate esters in personal care formulations |
US8293699B2 (en) | 2007-06-12 | 2012-10-23 | Rhodia Operations | Hard surface cleaning composition with hydrophilizing agent and method for cleaning hard surfaces |
US9682026B2 (en) | 2008-02-08 | 2017-06-20 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
US9376722B2 (en) | 2008-02-08 | 2016-06-28 | Colgate-Palmolive Company | Oral care methods and systems |
US20090202455A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
US20110085990A1 (en) * | 2008-02-08 | 2011-04-14 | Colgate-Palmolive Company | Oral care methods and systems |
US20120020897A1 (en) * | 2009-04-02 | 2012-01-26 | Colgate-Palmolive Company | Dentifrice composition |
US20110089073A1 (en) * | 2009-09-11 | 2011-04-21 | The Procter & Gamble Company | Methods And Compositions For Hydrophobic Modification Of Oral Cavity Surfaces |
WO2011031807A3 (fr) * | 2009-09-11 | 2013-04-25 | The Procter & Gamble Company | Procédés et compositions de modification hydrophobe de surfaces de cavité buccale |
US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
US20160312013A1 (en) * | 2013-12-05 | 2016-10-27 | Colgate-Palmolive Company | Method of measuring viscosity of gums |
US10017633B2 (en) * | 2013-12-05 | 2018-07-10 | Colgate-Palmolive Company | Method of measuring viscosity of gums |
US20180289599A1 (en) * | 2015-10-08 | 2018-10-11 | Colgate-Palmolive Company | Oral Care Compositions |
Also Published As
Publication number | Publication date |
---|---|
CA2516950C (fr) | 2012-09-25 |
WO2004075770A2 (fr) | 2004-09-10 |
US9034308B2 (en) | 2015-05-19 |
JP2006518744A (ja) | 2006-08-17 |
EP2281550A3 (fr) | 2012-07-18 |
BRPI0407746A (pt) | 2006-02-14 |
US9040025B2 (en) | 2015-05-26 |
US20090169493A1 (en) | 2009-07-02 |
MXPA05008302A (es) | 2005-09-20 |
RU2337734C2 (ru) | 2008-11-10 |
EP2281550A2 (fr) | 2011-02-09 |
KR20050105230A (ko) | 2005-11-03 |
WO2004075770A3 (fr) | 2005-03-10 |
EP1599182A2 (fr) | 2005-11-30 |
CN1750807A (zh) | 2006-03-22 |
EP1599182A4 (fr) | 2008-08-20 |
CN1750807B (zh) | 2010-05-12 |
US20090123396A1 (en) | 2009-05-14 |
RU2005129336A (ru) | 2006-03-10 |
CA2516950A1 (fr) | 2004-09-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9034308B2 (en) | Anti-sensitivity, anti-caries, anti-staining, anti-plaque ultra-mild oral hygiene agent | |
US6436370B1 (en) | Dental anti-hypersensitivity composition and method | |
US4096241A (en) | Tooth preparations | |
US20080031831A1 (en) | Oral anti-calculus compositions and methods of use thereof | |
CA2971909C (fr) | Composition dentaire anti-tartre et son procede d'utilisation | |
CA2806054C (fr) | Compositions pour soins buccaux exemptes de phosphate a base d'un agent antibacterien issu de magnolia | |
AU2015346163B2 (en) | Oral care composition containing zinc salts and calcium carbonate | |
CZ21593A3 (en) | Mixtures preventing the formation of tartar and bacterial plaque on teeth and containing azacycloalkane diphosphonates | |
US20100316579A1 (en) | Novel use of alkyl phosphate esters | |
JPH05339135A (ja) | 口腔用組成物 | |
US20050180927A1 (en) | Novel anti-bacterial compositions | |
Mason | Dental and mouthwash preparations | |
KR20040050363A (ko) | 금입자가 함유된 건강치약의 제조방법 | |
KR20070102184A (ko) | 항균력이 우수한 구강용 조성물 | |
AU2003213864A1 (en) | Novel anti-bacterial compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: RHODIA INC., NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:REIERSON, ROBERT LEE;DOMKE, TODD WILLIAM;REEL/FRAME:015070/0761 Effective date: 20040305 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |