US20040062676A1 - Alloy for use as stents - Google Patents

Alloy for use as stents Download PDF

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Publication number
US20040062676A1
US20040062676A1 US10/446,570 US44657003A US2004062676A1 US 20040062676 A1 US20040062676 A1 US 20040062676A1 US 44657003 A US44657003 A US 44657003A US 2004062676 A1 US2004062676 A1 US 2004062676A1
Authority
US
United States
Prior art keywords
alloys
alloy
stents
tantalum
accordance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/446,570
Other languages
English (en)
Inventor
Jens Trotzschel
Jurgen Wachter
Frank Kruger
Matthias Frericks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WC Heraus GmbH and Co KG
Original Assignee
WC Heraus GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WC Heraus GmbH and Co KG filed Critical WC Heraus GmbH and Co KG
Assigned to W.C. HERAEUS GMBH & CO. KG reassignment W.C. HERAEUS GMBH & CO. KG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FRERICKS, MATTHIAS, KRUGER, FRANK, TROTZSCHEL, JENS, WACHTER, JURGEN
Publication of US20040062676A1 publication Critical patent/US20040062676A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C27/00—Alloys based on rhenium or a refractory metal not mentioned in groups C22C14/00 or C22C16/00
    • C22C27/02—Alloys based on vanadium, niobium, or tantalum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys

Definitions

  • the invention concerns alloys composed essentially of niobium (Nb), tantalum (Ta) and zirconium (Zr) for use as stents, as well as stents made of these alloys.
  • Stents are well known in themselves and are described, for example, in U.S. Pat. No. 5,628,787, U.S. Pat. No. 5,630,840, and EP-A-0 873 734. Alloys that have been proposed for stents include not only special steels, but also nickel and tantalum alloys and niobium-zirconium alloys, in which the Nb content is greater than 90% and preferably greater than 95% or 98% (WO 02/43,787).
  • the object of the present invention is to provide alloys that satisfy stringent requirements with respect to biocompatibility, contain no known allergens, have good mechanical properties, are visible in radiographs, and can be identified in nuclear spin tomography.
  • stents made of the alloys of Nb, Ta, and Zr that are described below have the following combination of properties: good biocompatibility with very good mechanical properties, x-ray opacity, and identifiability in nuclear spin tomograms due to their magnetic properties. Alloy components that could cause problems, such as nickel, are absent, the x-ray opacity is not overly great as in the case of alloys with a very high Ta content, and identifiability with the nuclear spin method is an important advantage in view of the increasingly widespread use of this method.
  • the niobium content is greater than 50% and preferably greater than 80%, and the rest of the alloy consists essentially of Ta and Zr.
  • the Zr content is less than 5%, and the zirconium content is generally less than the tantalum content.
  • the niobium content is preferably less than 90%.
  • Preferred alloys have the following contents: 1. 50-98.9% Nb, 0.5-5% Zr, 0.6-49.5% Ta; 2. 90-98.9% Nb, 0.5-5% Zr, 0.6-9.5% Ta; 3. 80-97% Nb, 2-5% Zr, 1-18% Ta; 4. 80-90% Nb, 0.5-5% Zr, 5-19.5% Ta.
  • Alloys with a niobium content of 80-90% are especially preferred.
  • the increase in x-ray opacity and improvement of the mechanical properties work out favorably here—with the possibility of reducing the cross section of the mesh links of the stent.
  • the invention also concerns stents made of the alloys described above, especially stents in which the mesh links have a relatively small cross section.
  • alloys and stents made of the alloys are produced by common methods with which experts are familiar.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
US10/446,570 2002-09-27 2003-05-28 Alloy for use as stents Abandoned US20040062676A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10245516A DE10245516B4 (de) 2002-09-27 2002-09-27 Legierung zur Verwendung für Stents
DE10245516.3 2002-09-27

Publications (1)

Publication Number Publication Date
US20040062676A1 true US20040062676A1 (en) 2004-04-01

Family

ID=31969711

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/446,570 Abandoned US20040062676A1 (en) 2002-09-27 2003-05-28 Alloy for use as stents

Country Status (9)

Country Link
US (1) US20040062676A1 (ja)
EP (1) EP1403390B1 (ja)
JP (1) JP2004130128A (ja)
AT (1) ATE337415T1 (ja)
CA (1) CA2435557A1 (ja)
DE (2) DE10245516B4 (ja)
DK (1) DK1403390T3 (ja)
ES (1) ES2269889T3 (ja)
PT (1) PT1403390E (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060153729A1 (en) * 2005-01-13 2006-07-13 Stinson Jonathan S Medical devices and methods of making the same
US20070221300A1 (en) * 2003-02-10 2007-09-27 Jurgen Wachter Metal alloy for medical devices and implants
US20070276488A1 (en) * 2003-02-10 2007-11-29 Jurgen Wachter Medical implant or device
US20080038146A1 (en) * 2003-02-10 2008-02-14 Jurgen Wachter Metal alloy for medical devices and implants
US9470462B2 (en) 2012-12-14 2016-10-18 TITAN Metal Fabricators Heat exchanger for heating hydrochloric acid pickling solution, a system and method for pickling, and a method of manufacturing steel products

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050098241A1 (en) * 2003-11-11 2005-05-12 W. C. Heraeus Gmbh & Co. Kg Niobium-Zirconium Alloy for medical devices or their parts
CN115971472B (zh) * 2022-12-28 2024-09-17 宁夏东方智造科技有限公司 铌钨合金粉末、铌钨合金制品及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642546A (en) * 1970-03-04 1972-02-15 Surface Technology Corp Nitrided vanadium, columbium and tantalum base alloys
US4799977A (en) * 1987-09-21 1989-01-24 Fansteel Inc. Graded multiphase oxycarburized and oxycarbonitrided material systems
US5628787A (en) * 1993-01-19 1997-05-13 Schneider (Usa) Inc. Clad composite stent
US5630840A (en) * 1993-01-19 1997-05-20 Schneider (Usa) Inc Clad composite stent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933712A (en) * 1958-08-14 1963-08-14 Fansteel Metallurgical Corp Alloys of columbium and tantalum
FR1301628A (fr) * 1961-09-22 1962-08-17 United Aircraft Corp Alliages au niobium à grande résistance mécanique aux températures élevées
CH528598A (de) * 1967-04-12 1972-09-30 Starck Hermann C Fa Verfahren zur Herstellung von Legierungen oder Gemischen des Tantals oder Niobs
WO2002005863A1 (en) * 2000-07-14 2002-01-24 Advanced Cardiovascular Systems, Inc. Radiopaque stent composed of a binary alloy
AU2001218611A1 (en) * 2000-11-28 2002-06-11 Fortimedix B.V. Stent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642546A (en) * 1970-03-04 1972-02-15 Surface Technology Corp Nitrided vanadium, columbium and tantalum base alloys
US4799977A (en) * 1987-09-21 1989-01-24 Fansteel Inc. Graded multiphase oxycarburized and oxycarbonitrided material systems
US5628787A (en) * 1993-01-19 1997-05-13 Schneider (Usa) Inc. Clad composite stent
US5630840A (en) * 1993-01-19 1997-05-20 Schneider (Usa) Inc Clad composite stent

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070221300A1 (en) * 2003-02-10 2007-09-27 Jurgen Wachter Metal alloy for medical devices and implants
US20070276488A1 (en) * 2003-02-10 2007-11-29 Jurgen Wachter Medical implant or device
US20080038146A1 (en) * 2003-02-10 2008-02-14 Jurgen Wachter Metal alloy for medical devices and implants
US20100222866A1 (en) * 2003-02-10 2010-09-02 Jurgen Wachter Metal alloy for medical devices and implants
US8349249B2 (en) 2003-02-10 2013-01-08 Heraeus Precious Metals Gmbh & Co. Kg Metal alloy for medical devices and implants
US8403980B2 (en) 2003-02-10 2013-03-26 Heraeus Materials Technology Gmbh & Co. Kg Metal alloy for medical devices and implants
US20060153729A1 (en) * 2005-01-13 2006-07-13 Stinson Jonathan S Medical devices and methods of making the same
US7727273B2 (en) 2005-01-13 2010-06-01 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US20100228336A1 (en) * 2005-01-13 2010-09-09 Stinson Jonathan S Medical devices and methods of making the same
US7938854B2 (en) 2005-01-13 2011-05-10 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
EP1838359B2 (en) † 2005-01-13 2014-01-15 Boston Scientific Limited Medical devices comprising alloys
US9470462B2 (en) 2012-12-14 2016-10-18 TITAN Metal Fabricators Heat exchanger for heating hydrochloric acid pickling solution, a system and method for pickling, and a method of manufacturing steel products

Also Published As

Publication number Publication date
PT1403390E (pt) 2006-11-30
DE10245516B4 (de) 2004-09-30
DE10245516A1 (de) 2004-04-15
CA2435557A1 (en) 2004-03-27
EP1403390A1 (de) 2004-03-31
JP2004130128A (ja) 2004-04-30
ATE337415T1 (de) 2006-09-15
EP1403390B1 (de) 2006-08-23
DK1403390T3 (da) 2006-09-25
DE50304720D1 (de) 2006-10-05
ES2269889T3 (es) 2007-04-01

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Legal Events

Date Code Title Description
AS Assignment

Owner name: W.C. HERAEUS GMBH & CO. KG, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TROTZSCHEL, JENS;WACHTER, JURGEN;KRUGER, FRANK;AND OTHERS;REEL/FRAME:014123/0127

Effective date: 20030331

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION