US20030226907A1 - System comprising a nozzle and a fixing means therefor - Google Patents

System comprising a nozzle and a fixing means therefor Download PDF

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Publication number
US20030226907A1
US20030226907A1 US10/429,500 US42950003A US2003226907A1 US 20030226907 A1 US20030226907 A1 US 20030226907A1 US 42950003 A US42950003 A US 42950003A US 2003226907 A1 US2003226907 A1 US 2003226907A1
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United States
Prior art keywords
nozzle
range
apertures
nozzle system
recess
Prior art date
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Abandoned
Application number
US10/429,500
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English (en)
Inventor
Johannes Geser
Dieter Hochrainer
Herbert Wachtel
Stephen Dunne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to US10/429,500 priority Critical patent/US20030226907A1/en
Assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH reassignment BOEHRINGER INGELHEIM INTERNATIONAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WACHTEL, HERBERT, DUNNE, STEPHEN, GESER, JOHANNES, HOCHRAINER, DIETER
Publication of US20030226907A1 publication Critical patent/US20030226907A1/en
Priority to US10/982,991 priority patent/US7284713B2/en
Priority to US11/764,248 priority patent/US7681811B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/26—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/60—Arrangements for mounting, supporting or holding spraying apparatus
    • B05B15/65—Mounting arrangements for fluid connection of the spraying apparatus or its outlets to flow conduits

Definitions

  • the invention relates to a nozzle system for a delivery device for liquids, wherein the nozzle system comprises a nozzle and a device which fixes the nozzle in the delivery device.
  • the delivery device an atomiser, has a liquid reservoir from which a liquid is forced through the nozzle under pressure.
  • the nozzle fixing means may itself be secured by a second fixing, e.g., in the form of a check nut, or the fixing may itself be a check nut.
  • the fixing means on the nozzle outlet side has a specific geometry which minimises the amount of dispensed liquid deposited on the fixing means.
  • the present invention is part of a propellant-free device for nebulising pharmaceutical fluids.
  • a nebuliser according to the invention is used, for example, to produce an aerosol of droplets for inhalation through the mouth and pharyngeal cavity into the lungs of a patient, for nasal administration or for spraying the surface of the eye.
  • WO 91/14468 discloses an apparatus for propellant-free administration of a metered quantity of a liquid pharmaceutical for application by inhalation.
  • a further development of the device is described in detail in WO 97/12687.
  • Propellant-free liquids can easily be atomised using such devices.
  • liquid pharmaceutical formulations are stored in a reservoir. From there, they are conveyed through a riser tube into a pressure chamber from where they are forced through a nozzle.
  • the nozzle is held by a nozzle holder and the latter is secured by a check nut.
  • the check nut has a liquid inlet side and a liquid outlet side. On the liquid inlet side is an opening through which a liquid from the pressure chamber can enter the nozzle. On the opposite side, the end face of the nozzle, the liquid then passes through two nozzle apertures which are aligned so that the jets of liquid leaving the apertures strike one another and are thereby atomised.
  • the nozzle apertures are arranged in the inhaler in such a way that they are in direct contact with the outer environment.
  • this recess is funnel-shaped while in the region of the check nut this recess is in the form of a uniform cylinder.
  • the transition between the nozzle holder and check nut has a sharp edge so that the cross section of the recess is like an L in which the crossbar is inclined slightly downwards.
  • the entire recess in front of the nozzle aperture which is made up of the recess in the nozzle holder and the recess of the check nut, has a point of discontinuity in the elbow region of this L: the recess expands discontinuously, i.e., viewed from the base it first of all widens out and then bends sharply vertically in the region of the transition from the nozzle holder to the check nut.
  • the vertical direction corresponds to the direction of spraying of the emerging liquid, i.e., the perpendicular to the outside of the nozzle (end face).
  • inhalers normally deliver formulations based on water or mixtures of water and ethanol. They are able to nebulise a small amount of a liquid formulation in the therapeutically required dosage within a few seconds to produce an aerosol suitable for therapeutic inhalation. With the device, quantities of less than 100 microlitres can be nebulised, e.g., with one spray actuation, to produce an aerosol with an average particle size of less than 20 microns so that the inhalable part of the aerosol corresponds to the therapeutically effective amount.
  • Respimat® technology a pharmaceutical solution is converted by high pressure up to 500 bar into a low-speed aerosol mist destined for the lungs, which the patient can then breathe in.
  • a small amount of the liquid may be deposited from the outside as a film or as an accumulation of small droplets on the end face of the nozzle or on the end face of the fixing means for the nozzle or on the inside of the mouthpiece.
  • This fraction of the liquid is also referred to as the mouthpiece fraction within the scope of this specification. This mouthpiece fraction reduces the amount of liquid dispensed, with the result that the inhalable fraction of the quantity delivered is reduced by the mouthpiece fraction.
  • the amount of liquid deposited need not be constant in every spray actuation but may depend on numerous factors such as the spatial orientation of the device during the aerosol production or the ambient temperature, relative humidity, etc. This leads on the one hand to a certain variability, however minor, in the amount dispensed which is then available for the patient to take in (delivered dose). Of the delivered dose, some has such a small particle size that the particles can be breathed deep into the lungs and this fraction is known as the inhalable fraction. However, the present specification does not expressly differentiate between the inhalable fraction and the total quantity of aerosol available for the patient to breathe in unless otherwise stated or unless clearly apparent from the context.
  • the liquid deposited may also cause contamination of the outer surface of the nozzle system or of the mouthpiece, which may in turn affect the pharmaceutical quality of the next aerosol mist.
  • the proportion of liquid deposited on the outside of the nozzle system can be reduced by the particular geometry of the nozzle or nozzle fixing means.
  • the mouthpiece fraction can be reduced if the entire area above the nozzle aperture (i.e., the area through which the dispensed liquid “flies” on its way to the mouthpiece) is funnel-shaped and has no edges.
  • a further aim of the invention is to reduce the proportion of liquid which is deposited, from an aerosol mist, on the device for delivering the pharmaceutical liquid.
  • a further aim of the invention is to increase the inhalable fraction of the quantity delivered and to reduce the mouthpiece fraction.
  • a further aim is to optimise the quality of delivery of a liquid using atomisers having the Respimat® technology.
  • a nozzle system which consists of a nozzle having at least two nozzle apertures and a nozzle holder and optionally a check nut, wherein
  • the nozzle apertures formed on the end face of the nozzle or the nozzle channels opening into the nozzle apertures are arranged so that the jets leaving the nozzle apertures are aimed towards one another at an angle ⁇ ,
  • the nozzle is arranged in the nozzle holder and this is optionally fixed by a check nut located above it,
  • the nozzle holder or the check nut or both extend at least partially into the area in front of the nozzle apertures
  • the nozzle holder or, if the nozzle system has a check nut, the nozzle holder together with the check nut has an inner recess
  • the recess opens up the area of the nozzle system between the end face of the nozzle and the outside of the nozzle holder parallel thereto or, in the case of a check nut, the outside of said check nut parallel thereto, for a liquid emerging from the nozzle opening to pass through, so that this liquid can emerge from the nozzle, unimpeded by the nozzle holder and the check nut, if applicable, and can be distributed in the surrounding area.
  • the recess is funnel-shaped, preferably conical in construction.
  • the edge of this “continuously widening recess” is preferably in the form of a straight, elliptical, hyperbolic, convex or concave line. In any case the edge runs continuously.
  • the recess also widens continuously and does not merge into a cylindrical area.
  • the region of the recess with the smallest diameter, the base point, is located on the side of the nozzle holder which is adjacent to the end face of the nozzle.
  • the part of the recess with the largest diameter, the apex or vertex, is on the opposite side, i.e., the outside of the nozzle holder parallel to the end face of the nozzle or, in the case of a check nut, the outside of said check nut which is parallel thereto.
  • the small diameter of the recess is between 0.1 mm and 2 mm, preferably between 0.6 mm and 1.0 mm.
  • the larger diameter of the recess is between 3 mm and 10 mm, preferably between 5 mm and 8 mm.
  • the transition of the base end of the recess to the end face of the nozzle may be constructed as an edge or it may be continuous, as defined above, i.e., with no edges.
  • the nozzle system has a check nut.
  • the transition between the nozzle holder and the check nut is constructed with no edges, i.e., the continuous run of the recess is uninterrupted.
  • the present invention is based on nozzle systems as described, for example, in EP 0664733 or EP 1017469. These are preferably nozzles consisting of at least two superimposed plates, at least one of the plates having a second microstructure so that the superimposed plates define on one side a liquid inlet adjoining a channel system and/or a filter system which then opens into the liquid outlets.
  • Microstructured nozzled bodies of this kind are described for example in WO 94/07607 or WO 99/16530. Another embodiment is disclosed in the German Patent application filed under No. 10216101.1. Reference is hereby made to all the documents.
  • the nozzle body consists, for example, of two sheets of glass and/or silicon firmly attached to one another, at least one of these sheets having one or more microstructured channels which connect the nozzle inlet side to the nozzle outlet side.
  • the base part on the flat surface, there may be a set of channels to create a plurality of filter routes (filter channels) in collaboration with the substantially flat surface of the top part.
  • the base part may have a fill chamber the top of which is again formed by the top part. This fill chamber may be provided before or after the filter channels. It is also possible to have two fill chambers of this kind.
  • Another set of channels on the substantially flat surface of the base part which is provided downstream of the filter channels forms, together with the top part, a set of channels which create a plurality of nozzle outlet routes.
  • the overall cross sectional area of the nozzle outlets is 25 to 500 square micrometres.
  • the total cross sectional area is preferably 30 to 200 square micrometres.
  • this nozzle construction has only one nozzle aperture.
  • the filter channels and/or the fill chamber are omitted.
  • the filter channels are formed by projections arranged in a zigzag shape.
  • a zigzag configuration of this kind is formed by at least two rows of projections.
  • a number of rows of projections may also be formed, the projections being laterally offset from one another in order to construct additional rows which are skewed relative to these rows, these additional rows forming the zigzag configuration.
  • the inlet and outlet may each have a longitudinal slot for unfiltered or filtered fluid, each of the slots being substantially the same width as the filter and substantially the same height as the projections on the inlet and outlet sides of the filter.
  • the cross section of the throughflow passages formed by the projections may be perpendicular to the direction of flow of the fluid and may decrease from row to row, viewed in the direction of flow.
  • the projections arranged closer to the inlet side of the filter may be larger than the projections arranged closer to the outlet side of the filter.
  • the spacing between the base part and top part may taper in the region from the nozzle inlet side to the nozzle outlet side.
  • the zigzag configuration which is formed by the minimum of two rows of projections has an angle of inclination alpha of preferably 20° to 250°.
  • nozzle apertures In embodiments of the nozzle having a plurality of nozzle apertures, preferably all of them are formed on a common side. In such cases the nozzle apertures may be oriented so that the jets of liquid emerging from them meet in front of the nozzle aperture. Systems of this kind require nozzles with at least two apertures. Nozzles of this kind are preferred according to the invention.
  • the nozzle may be embedded in an elastomeric sleeve as described in WO 97/12683.
  • a sleeve of this kind is a ring or member having an opening into which the nozzle can be inserted. This opening surrounds the nozzle block over its entire outer surface, i.e., the surface which is perpendicular to the preferably linear axis formed by the nozzle inlet side and the nozzle outlet side.
  • the sleeve is open at the top and bottom so as not to impede either the supply of liquid to the nozzle inlet side of the nozzle or the delivery of the liquid.
  • This sleeve may in turn be inserted in a second sleeve.
  • the external form of the first sleeve is preferably conical.
  • the opening of the second sleeve is shaped accordingly.
  • the first sleeve may be made of an elastomer.
  • the nozzle is secured by the device according to the invention.
  • a nozzle of this kind is part of a nozzle system by means of which the nozzle is held at a defined place in the delivery device, preferably from outside in the direction of the hollow piston.
  • a nozzle system of this kind therefore consists of a nozzle and a nozzle holder and optionally a check nut. All the elements have an end face. This is the side which is oriented away from the side of the nozzle having the nozzle aperture, i.e., it faces outwards.
  • the inside of the end face of the nozzle holder or the check nut may come into contact with the liquid outlet side of the nozzle and thereby exert the force needed to secure the nozzle in the direction of the liquid inlet side of the nozzle.
  • the end face of the nozzle holder and/or of the check nut has or have a through-bore or hole in the form of a recess through which the aerosol can escape from the nozzle. Therefore, the nozzle apertures are in, or in a direct line below, the bore or the recess.
  • the recess is preferably constructed as an inner recess which widens continuously from the nozzle apertures.
  • Embodiments of the nozzle system wherein the recess is funnel-shaped, preferably conical, are advantageous.
  • nozzles having at least two nozzle apertures orientated so that the two jets of liquid leaving the nozzle body meet, the point of impact, the point where the jets of liquid meet and are atomised to form an aerosol, is preferably located close to the base of the recess, i.e., in the region of the nozzle aperture. It is obvious that in such a case the recess is one of the areas particularly at risk of liquid being deposited thereon.
  • This invention is preferably used in a nebuliser of Respimat® technology, which is described in more detail hereinafter.
  • the preferred atomiser essentially comprises a lower and an upper housing mounted to be rotatable relative to one another, the upper part of the housing containing a spring housing with spring which is tensioned by rotating the two housing parts by means of a locking clamping mechanism preferably in the form of a screw thread or gear and is released by pressing a release button on the upper part of the housing.
  • This moves a power take-off flange connected to a hollow piston on the lower end of which a container can be fitted and at the upper end of which are found a valve and a pressure chamber which is connected for fluid transmission to the nozzle or the nozzle system formed in the upwardly open part of the upper housing part.
  • the liquid is sucked in by the hollow piston and pumped to the pressure chamber from where it is expelled through the nozzle in the form of an aerosol.
  • the hollow piston with valve body corresponds to a device disclosed in WO 97/12687. It projects partially into the cylinder of the pump housing and is disposed to be axially movable in the cylinder. Reference is made particularly to FIGS. 1-4—especially FIG. 3—and the associated parts of the description.
  • the hollow piston with valve body exerts, at its high pressure end, a pressure of 5 to 60 Mpa (about 50 to 600 bar), preferably 10 to 60 Mpa (about 100 to 600 bar) on the fluid, the measured amount of active substance solution.
  • the valve body is preferably mounted at the end of the hollow piston which faces the nozzle body.
  • the valve body is connected for fluid transmission with the nozzle.
  • the delivery device also comprises a locking clamping mechanism.
  • This contains a spring, preferably a cylindrical helical compression spring, as a store for the mechanical energy.
  • the spring acts on the power take-off flange as a spring member the movement of which is determined by the position of a locking member.
  • the travel of the power take-off flange is precisely limited by an upper stop and a lower stop.
  • the spring is preferably tensioned via a stepping-up gear, e.g., a helical sliding gear, by an external torque which is generated when the upper housing part is turned relative to the spring housing in the lower housing part.
  • the upper housing part and the power take-off flange contain a single- or multi-speed spline gear.
  • the locking member with the engaging locking surfaces is arranged in an annular configuration around the power take-off flange. It consists for example of a ring of plastics or metal which is inherently radially elastically deformable. The ring is arranged in a plane perpendicular to the axis of the atomiser. After the tensioning of the spring, the locking surfaces of the locking member slide into the path of the power take-off flange and prevent the spring from being released.
  • the locking member is actuated by means of a button. The actuating button is connected or coupled to the locking member.
  • the actuating button is moved parallel to the annular plane, preferably into the atomiser, and the deformable ring is thereby deformed in the annular plane. Details of the construction of the locking clamping mechanism are described in WO 97/20590.
  • the lower housing part is pushed axially over the spring housing and covers the bearing, the drive for the spindle and the storage container for the fluid.
  • the upper part of the housing is rotated relative to the lower part, the lower part taking the spring housing with it.
  • the spring meanwhile is compressed and biased by means of the helical sliding gear, and the clamping mechanism engages automatically.
  • the angle of rotation is preferably a whole-number fraction of 360 degrees, e.g., 180 degrees.
  • the power take-off component in the upper housing part is moved along by a given amount, the hollow piston is pulled back inside the cylinder in the pump housing, as a result of which some of the fluid from the storage container is sucked into the high pressure chamber in front of the nozzle.
  • a plurality of replaceable storage containers containing the fluid to be atomised can be inserted in the atomiser one after another and then used.
  • the storage container contains the propellant-free aerosol preparation.
  • the atomising process is initiated by gently pressing the actuating button.
  • the clamping mechanism then opens the way for the power take-off component.
  • the biased spring pushes the piston into the cylinder in the pump housing.
  • the fluid emerges from the nozzle of the atomiser in the form of a spray.
  • the liquid pharmaceutical preparation hits the nozzle body at an entry pressure of up to 600 bar, preferably 200 to 300 bar and is atomised through the nozzle openings into an inhalable aerosol.
  • the preferred particle sizes of the aerosol are up to 20 microns, preferably 3 to 10 microns. Volumes of 10 to 50 microlitres are preferably delivered, volumes of 10 to 20 microlitres are more preferable, whilst a volume of 15 microlitres per spray is particularly preferred.
  • the components of the atomiser consist of a material which is suited to its purpose.
  • the housing of the atomiser and—insofar as the operation allows—other parts are also preferably made of plastics, e.g., by injection moulding. For medical uses, physiologically harmless materials are used.
  • a nebuliser according to the invention is cylindrical in shape and has a handy size of less than 9 to 15 cm long and 2 to 4 cm wide, so that it can be carried anywhere by the patient.
  • FIG. 1 Graph for investigating nozzle systems with two nozzle apertures directed towards one another: dependency of the mouthpiece fraction (“deposition in the mouthpiece”) on the impact height h for a nozzle system with a discontinuously expanding recess and for a nozzle system according to the invention with a conical recess,
  • FIG. 2 A graph for investigating nozzle systems with two nozzle apertures directed towards each other: dependency of the aerosol quality on the height of impact,
  • FIG. 3 A graph for investigating nozzle systems with two nozzle openings directed towards one another: dependency of the mouthpiece fraction and the quality of the inhalable fraction on the height of impact,
  • FIG. 4 A graph for investigating nozzle systems with two nozzle apertures directed towards one another: dependency of the mouthpiece fraction on the cone angle 2 ⁇ nozzle fixing systems with a conical recess,
  • FIGS. 5 , 6 Nozzles with two nozzle apertures directed towards one another: influence of the angle of impact a on the inhalable fraction and the mouthpiece fraction in nozzle fixing systems with a conical recess,
  • FIG. 7 A view of a first embodiment of a nozzle system in side elevation, partially in section,
  • FIG. 8 A view of a second embodiment of a nozzle system in side elevation, partly in section,
  • FIG. 9 A diagrammatic view of a nozzle system according to the invention in side elevation, in section,
  • FIG. 10 A diagrammatic view of an embodiment of a nozzle member in side elevation, in section,
  • FIGS. 11 a/b Diagram of the Respimat® type nebuliser.
  • FIG. 1 shows the dependency of the mouthpiece fraction (“deposition in the mouthpiece”) on the height of impact h for a nozzle system with a discontinuously expanding recess (A) and for a nozzle system according to the invention with a conical recess (B).
  • This graph shows the dependency of the mouthpiece fraction on the height of impact. Accordingly, the mouthpiece fraction can be reduced by increasing the height of impact h.
  • FIG. 1 also shows that the special construction of the nozzle system according to the invention in the region in front of the nozzle apertures leads to a substantial reduction in the mouthpiece fraction compared with conventional systems.
  • FIG. 3 shows the mouthpiece fraction in milligrams and the inhalable fraction in percent by volume (proportion by volume of the aerosol containing particles with diameters of less than 5.8 ⁇ m, as detected by a laser beam) as a function of the height of impact h.
  • the mouthpiece fraction decreases rapidly as the height of impact h increases.
  • the inhalable fraction i.e., the quality of atomisation, is not reduced to the same extent.
  • the recesses in front of the nozzle aperture are conical and have a cone angle 2 ⁇ in the range between 55° and 155°, preferably in the range between 70° and 140°.
  • the embodiments which have cone angles 2 ⁇ in the range from 70° to 85° or in the range between 95° and 140°, particularly in the range between 105° and 125°, have even smaller mouthpiece fractions. The minimum is obtained with a cone angle 2 ⁇ 110°.
  • the present invention relates to particular nozzles which may advantageously be incorporated in the nozzle systems according to the invention.
  • These nozzles are characterised in that the point of collision where the jets meet has a height of impact h above the nozzle apertures in the range between 20 ⁇ m and 85 ⁇ m, preferably in the range between 25 ⁇ m and 75 ⁇ m. If the height of impact is within the range specified, the various objectives can all advantageously be met, by achieving in particular a low mouthpiece fraction and reliable steering of the jets of liquid towards one another whilst obtaining a high inhalable fraction.
  • Nozzles wherein the point of collision where the jets meet has a height of impact h above the nozzle apertures in the range between 35 ⁇ m and 75 ⁇ m are advantageous. With the impact height in this range the parameters which influence one another are brought to an optimum level.
  • Embodiments of the nozzles wherein the angle ⁇ is in the range from 50° to 110°, preferably from 65° to 95° and more particularly in the range from 75° to 90° are advantageous.
  • FIGS. 5 and 6 show the effect of the angle of impact ⁇ on the inhalable fraction and the mouthpiece fraction. Both these fractions increase as the angle of impact ⁇ increases. With regard to the quality of atomisation it is preferable for the jets to meet head-on if possible. Large angles ensure a high inhalable fraction, i.e., a high volume proportion of small particles with diameters less than 5.8 ⁇ m in the spray mist.
  • the spacing a of the nozzle apertures is in the range from 40 ⁇ m to 125 ⁇ m, preferably in the range from 50 ⁇ m to 115 ⁇ m, more particularly in the range from 60 ⁇ m to 105 ⁇ m.
  • Advantageous embodiments of the nozzle system are characterised in that only the nozzle holder extends into the area in front of the nozzle apertures in the assembled state. This avoids any joints between the nozzle holder and check nut in the region of the nozzle apertures. Joints are a particular problem in terms of the accumulation of aerosol particles as, once deposited, any particles here are not generally released again.
  • FIGS. 7, 8, 9 and 10 Two embodiments shown in FIGS. 7, 8, 9 and 10 illustrate the invention in more detail.
  • FIG. 7 shows a first embodiment of the nozzle system 1 in side elevation, partly in section.
  • the nozzle holder 4 is clamped to the housing 7 by means of a check nut 2 and this secures the nozzle 3 .
  • the recess 5 is conical in shape, in that it widens out continuously as its distance from the nozzle apertures increases.
  • the recess 5 has a cone angle 2 ⁇ , whilst FIG. 7 shows by way of example a plurality of different cone angles, with the result that this Figure shows five different embodiments of the recess 5 and hence of the nozzle system 1 , all basically the same. Specifically, it shows cone angles 2 ⁇ of 70°, 80°, 90°, 100° and 110°.
  • the recess 5 is formed exclusively by the nozzle holder 4 .
  • FIG. 8 shows a second embodiment, again in side elevation and partly in section, wherein both the nozzle holder 4 and the check nut 2 extend into the area in front of the nozzle apertures.
  • the nozzle system 1 shown in FIG. 8 corresponds to the nozzle system described above.
  • the same reference numerals have been used for corresponding components, and therefore we refer to the description of FIG. 7 with regard to the components of similar construction.
  • FIG. 9 again shows a nozzle system 1 according to the invention.
  • This comprises a recess 5 of conical shape.
  • the recess 5 does not contain any steps. Such steps may occur in particular in the area where the check nut engages in the nozzle holder. In such cases, particles of the spray mist may accumulate on the edges of the step and thus contribute to the mouthpiece fraction.
  • FIG. 10 is a diagrammatic view of a detail of an embodiment of a nozzle member 3 shown in sectional side view.
  • FIG. 11 a shows a longitudinal section through the atomiser with the spring under tension
  • FIG. 11 b shows a longitudinal section through the atomiser with the spring released.
  • the upper housing part ( 51 ) contains the pump housing ( 52 ), on the end of which is mounted the holder ( 53 ) for the atomiser nozzle. In the holder is the expanding recess ( 54 ) and the nozzle body ( 55 ).
  • the hollow piston ( 57 ) fixed in the power take-off flange ( 56 ) of the locking clamping mechanism projects partly into the cylinder of the pump housing. At its end the hollow piston carries the valve body ( 58 ).
  • the hollow piston is sealed off by the gasket ( 59 ).
  • the stop ( 60 ) Inside the upper housing part is the stop ( 60 ) on which the power take-off flange rests when the spring is relaxed.
  • the stop ( 61 ) Located on the power take-off flange is the stop ( 61 ) on which the power take-off flange rests when the spring is under tension. After the tensioning of the spring, the locking member ( 62 ) slides between the stop ( 61 ) and a support ( 63 ) in the upper housing part. The actuating button ( 64 ) is connected to the locking member. The upper housing part ends in the mouthpiece ( 65 ) and is closed off by the removable protective cap ( 66 ).
  • the spring housing ( 67 ) with compression spring ( 68 ) is rotatably mounted on the upper housing part by means of the snap-fit lugs ( 69 ) and rotary bearings.
  • the lower housing part ( 70 ) is pushed over the spring housing.
  • Inside the spring housing is the replaceable storage container ( 71 ) for the fluid ( 72 ) which is to be atomised.
  • the storage container is closed off by the stopper ( 73 ), through which the hollow piston projects into the storage container and dips its end into the fluid (supply of active substance solution).
  • the spindle ( 74 ) for the mechanical counter (optional) is mounted on the outside of the spring housing.
  • the drive pinion ( 75 ) is located at the end of the spindle facing the upper housing part.
  • the slider ( 76 ) On the spindle is the slider ( 76 ).

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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nozzles (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Closures For Containers (AREA)
US10/429,500 2002-05-16 2003-05-02 System comprising a nozzle and a fixing means therefor Abandoned US20030226907A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/429,500 US20030226907A1 (en) 2002-05-16 2003-05-02 System comprising a nozzle and a fixing means therefor
US10/982,991 US7284713B2 (en) 2002-05-16 2004-11-05 System comprising a nozzle and a fixing means therefor
US11/764,248 US7681811B2 (en) 2002-05-16 2007-06-18 System comprising a nozzle and a fixing means therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10221732.7 2002-05-16
DE10221732 2002-05-16
US38212902P 2002-05-21 2002-05-21
US10/429,500 US20030226907A1 (en) 2002-05-16 2003-05-02 System comprising a nozzle and a fixing means therefor

Related Child Applications (1)

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US10/982,991 Continuation US7284713B2 (en) 2002-05-16 2004-11-05 System comprising a nozzle and a fixing means therefor

Publications (1)

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US20030226907A1 true US20030226907A1 (en) 2003-12-11

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US10/429,500 Abandoned US20030226907A1 (en) 2002-05-16 2003-05-02 System comprising a nozzle and a fixing means therefor
US10/982,991 Expired - Lifetime US7284713B2 (en) 2002-05-16 2004-11-05 System comprising a nozzle and a fixing means therefor
US11/764,248 Expired - Lifetime US7681811B2 (en) 2002-05-16 2007-06-18 System comprising a nozzle and a fixing means therefor

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US11/764,248 Expired - Lifetime US7681811B2 (en) 2002-05-16 2007-06-18 System comprising a nozzle and a fixing means therefor

Country Status (17)

Country Link
US (3) US20030226907A1 (fr)
EP (1) EP1509266B1 (fr)
JP (1) JP2005530535A (fr)
AR (1) AR040029A1 (fr)
AT (1) ATE435046T1 (fr)
AU (1) AU2003226822A1 (fr)
CA (1) CA2484578A1 (fr)
CY (1) CY1109415T1 (fr)
DE (1) DE50311664D1 (fr)
DK (1) DK1509266T3 (fr)
ES (1) ES2329357T3 (fr)
PE (1) PE20040039A1 (fr)
PT (1) PT1509266E (fr)
SI (1) SI1509266T1 (fr)
TW (1) TW200404613A (fr)
UY (1) UY27806A1 (fr)
WO (1) WO2003097139A1 (fr)

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US20090194099A1 (en) * 2003-01-14 2009-08-06 Boehringer Ingelheim International Gmbh Nozzle-System For A Dispenser For Fluids consisting Of A Nozzle And A Nozzle-Holder And/or A Screw Cap
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US20170128679A1 (en) * 2014-06-27 2017-05-11 Sergio BELFORTI A powder inhaler device
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
WO2020245744A1 (fr) * 2019-06-05 2020-12-10 Tyco Fire Products Lp Dispositif de visée de buse

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CA2526362C (fr) 2003-05-20 2012-10-09 James F. Collins Systeme de distribution de medicaments ophtalmiques
US8545463B2 (en) 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
DE102004011381A1 (de) * 2004-03-05 2005-09-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Impaktionsdüse für treibgasbetriebene Dosieraerosole
DE102006025884A1 (de) * 2006-06-02 2007-12-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Adapter mit einem Anschluss für einen Zerstäuber
CN101528119A (zh) * 2006-10-30 2009-09-09 皇家飞利浦电子股份有限公司 混浊介质成像
CN101939059B (zh) * 2007-12-12 2012-05-30 爱鹿赫德铜制品制造有限公司 具有可调腔的平滑腔喷嘴
DK2271434T3 (da) * 2008-04-22 2020-06-02 Spray Nozzle Eng Pty Ltd Forbedringer til sprøjtedyseanordninger
GB2471712A (en) * 2009-07-10 2011-01-12 De Beers Centenary AG Gemstone alignment system
EA201390122A1 (ru) 2010-07-15 2014-05-30 Коринтиан Офтэлмик, Инк. Устройство для генерирования капель
JP2013531548A (ja) 2010-07-15 2013-08-08 コリンシアン オフサルミック，インコーポレイティド 遠隔治療及び遠隔モニタリングを実施する方法及びシステム
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
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CN104487028A (zh) 2011-12-12 2015-04-01 艾诺维亚股份有限公司 高模量聚合物喷射器机构、喷射器装置及其使用方法
DE102013201785B3 (de) * 2013-02-04 2014-05-22 Lechler Gmbh Form zur Herstellung von Zerstäuberdüsen, Formensatz, Negativform und Verfahren zum Herstellen einer Zerstäuberdüse
EP3043927A4 (fr) 2013-09-09 2017-08-30 Omnimist Ltd. Appareil de pulvérisation du type atomiseur
CA3066408A1 (fr) 2017-06-10 2018-12-13 Eyenovia, Inc. Procedes et dispositifs pour manipuler un fluide et administrer le fluide a l'oeil
CN109909086B (zh) * 2018-12-25 2020-12-18 江苏大学 一种气液两相流雾化喷嘴及其设计方法
US20230057751A1 (en) * 2020-02-13 2023-02-23 Shl Medical Ag Aerosol assembly for a medicament delivery device
WO2021260179A1 (fr) 2020-06-26 2021-12-30 Softhale Nv Appareil de buse inversée et procédé

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US3769037A (en) * 1971-08-18 1973-10-30 Pillsbury Co Method of foam injecting flavor or texture improving substances into meat
USRE30486E (en) * 1977-10-25 1981-01-20 Nozzle assemblies for atomizing and mixing different fluids and combining the mixture with solids and the like
US4258885A (en) * 1979-03-23 1981-03-31 Legeza Thomas B Nozzle tip and method of manufacture
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US4623337A (en) * 1984-03-08 1986-11-18 Alpha Group, Inc. Liquid dispensing apparatus
US5060869A (en) * 1989-10-10 1991-10-29 Wagner Spray Tech Corporation Ceramic flat spray tip
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Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090194099A1 (en) * 2003-01-14 2009-08-06 Boehringer Ingelheim International Gmbh Nozzle-System For A Dispenser For Fluids consisting Of A Nozzle And A Nozzle-Holder And/or A Screw Cap
WO2007141203A1 (fr) * 2006-06-02 2007-12-13 Boehringer Ingelheim International Gmbh Pulvérisateur
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
US20170128679A1 (en) * 2014-06-27 2017-05-11 Sergio BELFORTI A powder inhaler device
WO2020245744A1 (fr) * 2019-06-05 2020-12-10 Tyco Fire Products Lp Dispositif de visée de buse

Also Published As

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EP1509266B1 (fr) 2009-07-01
US7284713B2 (en) 2007-10-23
WO2003097139A8 (fr) 2005-03-10
PE20040039A1 (es) 2004-02-19
UY27806A1 (es) 2003-12-31
EP1509266A1 (fr) 2005-03-02
JP2005530535A (ja) 2005-10-13
ES2329357T3 (es) 2009-11-25
SI1509266T1 (sl) 2009-12-31
US7681811B2 (en) 2010-03-23
DE50311664D1 (de) 2009-08-13
WO2003097139A1 (fr) 2003-11-27
PT1509266E (pt) 2009-08-17
CA2484578A1 (fr) 2003-11-27
AR040029A1 (es) 2005-03-09
DK1509266T3 (da) 2009-10-19
TW200404613A (en) 2004-04-01
AU2003226822A1 (en) 2003-12-02
ATE435046T1 (de) 2009-07-15
US20070257134A1 (en) 2007-11-08
US20050077392A1 (en) 2005-04-14
CY1109415T1 (el) 2014-08-13

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