US20030082153A1 - Stem cells that transform to beating cardiomyocytes - Google Patents

Stem cells that transform to beating cardiomyocytes Download PDF

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Publication number
US20030082153A1
US20030082153A1 US10/003,400 US340001A US2003082153A1 US 20030082153 A1 US20030082153 A1 US 20030082153A1 US 340001 A US340001 A US 340001A US 2003082153 A1 US2003082153 A1 US 2003082153A1
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US
United States
Prior art keywords
cells
cell
growth factor
cardiomyocyte
kit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/003,400
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English (en)
Inventor
Neal Epstein
Thiru Gopal
Steve Winitsky
Shahin Hassanzadeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HEALTH AND HUMAN SERVICES GOVERNMENT OF United States, Secretary of
US Government
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US Government
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Priority to US10/003,400 priority Critical patent/US20030082153A1/en
Assigned to HEALTH AND HUMAN SERVICES, GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF, THE reassignment HEALTH AND HUMAN SERVICES, GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF, THE ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EPSTEIN, NEAL D., GOPAL, THIRU V., HASSANZADEH, SHAHIN, WINITSKY, STEVEN
Priority to EP02773854A priority patent/EP1444329B1/fr
Priority to DE60216959T priority patent/DE60216959D1/de
Priority to PCT/US2002/033860 priority patent/WO2003035838A2/fr
Priority to AT02773854T priority patent/ATE348878T1/de
Priority to CA002464088A priority patent/CA2464088A1/fr
Priority to JP2003538339A priority patent/JP4377690B2/ja
Priority to AU2002337949A priority patent/AU2002337949B1/en
Publication of US20030082153A1 publication Critical patent/US20030082153A1/en
Priority to US10/863,004 priority patent/US7220582B2/en
Priority to US11/747,060 priority patent/US20070212423A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
US10/003,400 2001-10-22 2001-10-22 Stem cells that transform to beating cardiomyocytes Abandoned US20030082153A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US10/003,400 US20030082153A1 (en) 2001-10-22 2001-10-22 Stem cells that transform to beating cardiomyocytes
AU2002337949A AU2002337949B1 (en) 2001-10-22 2002-10-22 Stem cells that transform to beating cardiomyocytes
AT02773854T ATE348878T1 (de) 2001-10-22 2002-10-22 Sich in schlagende kardiomyozyten verwandelnde stammzellen
DE60216959T DE60216959D1 (de) 2001-10-22 2002-10-22 Sich in schlagende kardiomyozyten verwandelnde stammzellen
PCT/US2002/033860 WO2003035838A2 (fr) 2001-10-22 2002-10-22 Cellules souches se transformant en cardiomyocytes a battements spontanes
EP02773854A EP1444329B1 (fr) 2001-10-22 2002-10-22 Cellules souches se transformant en cardiomyocytes a battements spontanes
CA002464088A CA2464088A1 (fr) 2001-10-22 2002-10-22 Cellules souches se transformant en cardiomyocytes a battements spontanes
JP2003538339A JP4377690B2 (ja) 2001-10-22 2002-10-22 拍動する心筋細胞へ形質転換する幹細胞
US10/863,004 US7220582B2 (en) 2001-10-22 2004-06-07 Stem cells that transform to beating cardiomyocytes
US11/747,060 US20070212423A1 (en) 2001-10-22 2007-05-10 Stem cells that transform to beating cardiomyocytes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/003,400 US20030082153A1 (en) 2001-10-22 2001-10-22 Stem cells that transform to beating cardiomyocytes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/863,004 Continuation US7220582B2 (en) 2001-10-22 2004-06-07 Stem cells that transform to beating cardiomyocytes

Publications (1)

Publication Number Publication Date
US20030082153A1 true US20030082153A1 (en) 2003-05-01

Family

ID=21705682

Family Applications (3)

Application Number Title Priority Date Filing Date
US10/003,400 Abandoned US20030082153A1 (en) 2001-10-22 2001-10-22 Stem cells that transform to beating cardiomyocytes
US10/863,004 Expired - Fee Related US7220582B2 (en) 2001-10-22 2004-06-07 Stem cells that transform to beating cardiomyocytes
US11/747,060 Abandoned US20070212423A1 (en) 2001-10-22 2007-05-10 Stem cells that transform to beating cardiomyocytes

Family Applications After (2)

Application Number Title Priority Date Filing Date
US10/863,004 Expired - Fee Related US7220582B2 (en) 2001-10-22 2004-06-07 Stem cells that transform to beating cardiomyocytes
US11/747,060 Abandoned US20070212423A1 (en) 2001-10-22 2007-05-10 Stem cells that transform to beating cardiomyocytes

Country Status (8)

Country Link
US (3) US20030082153A1 (fr)
EP (1) EP1444329B1 (fr)
JP (1) JP4377690B2 (fr)
AT (1) ATE348878T1 (fr)
AU (1) AU2002337949B1 (fr)
CA (1) CA2464088A1 (fr)
DE (1) DE60216959D1 (fr)
WO (1) WO2003035838A2 (fr)

Cited By (10)

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US20040126879A1 (en) * 2002-08-29 2004-07-01 Baylor College Of Medicine Heart derived cells for cardiac repair
US20050221480A1 (en) * 2002-03-06 2005-10-06 Trans-Science, Inc. Self-renewing pluripotent hepatic stem cells
WO2006020322A3 (fr) * 2004-07-19 2006-07-27 Univ Columbia Systeme d'essai permettant de suivre de cellules transformees par genie genetique pour modifier les fonctions d'un syncytium
EP1696995A2 (fr) * 2003-12-24 2006-09-06 Medtronic, Inc. Procedes d'utilisation des genes hcn pour le traitement d'arythmies cardiaques
US7166280B2 (en) 2000-04-06 2007-01-23 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
US20080213231A1 (en) * 2005-07-15 2008-09-04 Kyoto University Pluripotent Stem Cell Cloned From Single Cell Derived From Skeletal Muscle Tissue
US20080241111A1 (en) * 2005-03-04 2008-10-02 Kyoto University Pluripotent Stem Cell Derived from Cardiac Tissue
US20100278787A1 (en) * 2007-07-18 2010-11-04 Cellartis Ab Cardiomyocyte-like cell clusters derived from hbs cells
US20100303769A1 (en) * 2000-04-06 2010-12-02 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
US9867854B2 (en) 2005-03-04 2018-01-16 Kyoto University Therapeutic method using cardiac tissue-derived pluripotent stem cells

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US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
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CA2550274A1 (fr) 2003-11-12 2005-05-26 Acea Biosciences, Inc. Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules
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EP2198010A4 (fr) * 2007-09-12 2010-10-06 Univ California Compositions et procédés pour améliorer l'efficacité fonctionnelle de cardiomyocytes dérivés d'une cellule souche
WO2009092005A2 (fr) * 2008-01-18 2009-07-23 The J. David Gladstone Institutes Procédés de génération de cardiomyocytes et progéniteurs cardiaques et compositions
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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166280B2 (en) 2000-04-06 2007-01-23 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
US20070196343A1 (en) * 2000-04-06 2007-08-23 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
US20100303769A1 (en) * 2000-04-06 2010-12-02 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
US20050221480A1 (en) * 2002-03-06 2005-10-06 Trans-Science, Inc. Self-renewing pluripotent hepatic stem cells
US20040126879A1 (en) * 2002-08-29 2004-07-01 Baylor College Of Medicine Heart derived cells for cardiac repair
EP1696995A4 (fr) * 2003-12-24 2009-03-04 Medtronic Inc Procedes d'utilisation des genes hcn pour le traitement d'arythmies cardiaques
US8859273B2 (en) 2003-12-24 2014-10-14 Medtronic, Inc. Methods of using HCN genes to treat cardiac arrhythmias
EP1696995A2 (fr) * 2003-12-24 2006-09-06 Medtronic, Inc. Procedes d'utilisation des genes hcn pour le traitement d'arythmies cardiaques
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US7220582B2 (en) 2007-05-22
EP1444329A2 (fr) 2004-08-11
WO2003035838A3 (fr) 2003-07-17
JP4377690B2 (ja) 2009-12-02
EP1444329A4 (fr) 2004-11-24
US20070212423A1 (en) 2007-09-13
AU2002337949B1 (en) 2003-05-06
ATE348878T1 (de) 2007-01-15
EP1444329B1 (fr) 2006-12-20
US20050058633A1 (en) 2005-03-17
CA2464088A1 (fr) 2003-05-01
DE60216959D1 (de) 2007-02-01
WO2003035838A2 (fr) 2003-05-01
JP2005506845A (ja) 2005-03-10

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